ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-phenylalanine catabolic process (GO:0006559)	7.58833002
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.58833002
3	L-phenylalanine metabolic process (GO:0006558)	7.25960032
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.25960032
5	aromatic amino acid family catabolic process (GO:0009074)	6.82606294
6	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.44949495
7	triglyceride catabolic process (GO:0019433)	6.24392159
8	indole-containing compound catabolic process (GO:0042436)	6.15883267
9	indolalkylamine catabolic process (GO:0046218)	6.15883267
10	tryptophan catabolic process (GO:0006569)	6.15883267
11	biotin metabolic process (GO:0006768)	6.13300157
12	regulation of sequestering of triglyceride (GO:0010889)	6.07251534
13	kynurenine metabolic process (GO:0070189)	6.03677657
14	bile acid biosynthetic process (GO:0006699)	5.96420488
15	low-density lipoprotein particle clearance (GO:0034383)	5.81629583
16	tryptophan metabolic process (GO:0006568)	5.79390702
17	glyoxylate metabolic process (GO:0046487)	5.77023039
18	alpha-linolenic acid metabolic process (GO:0036109)	5.70636034
19	urea cycle (GO:0000050)	5.68924066
20	urea metabolic process (GO:0019627)	5.68924066
21	acylglycerol catabolic process (GO:0046464)	5.68283607
22	neutral lipid catabolic process (GO:0046461)	5.68283607
23	high-density lipoprotein particle remodeling (GO:0034375)	5.63132591
24	negative regulation of fibrinolysis (GO:0051918)	5.62759620
25	regulation of fibrinolysis (GO:0051917)	5.42003694
26	protein carboxylation (GO:0018214)	5.38019981
27	peptidyl-glutamic acid carboxylation (GO:0017187)	5.38019981
28	sulfur amino acid catabolic process (GO:0000098)	5.36110984
29	cysteine metabolic process (GO:0006534)	5.32025393
30	complement activation, alternative pathway (GO:0006957)	5.30575713
31	regulation of protein activation cascade (GO:2000257)	5.28943550
32	fatty acid transmembrane transport (GO:1902001)	5.28922647
33	nitrogen cycle metabolic process (GO:0071941)	5.23317502
34	serine family amino acid catabolic process (GO:0009071)	5.13328026
35	bile acid metabolic process (GO:0008206)	5.10119375
36	aromatic amino acid family metabolic process (GO:0009072)	4.95853702
37	diacylglycerol metabolic process (GO:0046339)	4.94262398
38	regulation of complement activation (GO:0030449)	4.93556189
39	reverse cholesterol transport (GO:0043691)	4.92932375
40	regulation of triglyceride catabolic process (GO:0010896)	4.92563452
41	regulation of cholesterol esterification (GO:0010872)	4.92260713
42	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.91546788
43	fatty acid homeostasis (GO:0055089)	4.89324255
44	plasma lipoprotein particle remodeling (GO:0034369)	4.82869419
45	protein-lipid complex remodeling (GO:0034368)	4.82869419
46	macromolecular complex remodeling (GO:0034367)	4.82869419
47	tyrosine metabolic process (GO:0006570)	4.81376956
48	homocysteine metabolic process (GO:0050667)	4.73248567
49	acylglycerol homeostasis (GO:0055090)	4.69248255
50	triglyceride homeostasis (GO:0070328)	4.69248255
51	phospholipid efflux (GO:0033700)	4.65726487
52	alpha-amino acid catabolic process (GO:1901606)	4.65222702
53	negative regulation of sterol transport (GO:0032372)	4.61961711
54	negative regulation of cholesterol transport (GO:0032375)	4.61961711
55	amino-acid betaine metabolic process (GO:0006577)	4.60291172
56	lysine metabolic process (GO:0006553)	4.55289536
57	lysine catabolic process (GO:0006554)	4.55289536
58	cellular ketone body metabolic process (GO:0046950)	4.48137324
59	plasma lipoprotein particle clearance (GO:0034381)	4.46201470
60	imidazole-containing compound metabolic process (GO:0052803)	4.44194877
61	glycine metabolic process (GO:0006544)	4.41043227
62	coenzyme catabolic process (GO:0009109)	4.40803723
63	bile acid and bile salt transport (GO:0015721)	4.38695391
64	carnitine shuttle (GO:0006853)	4.36219958
65	indolalkylamine metabolic process (GO:0006586)	4.35991372
66	negative regulation of complement activation (GO:0045916)	4.33010439
67	cellular amino acid catabolic process (GO:0009063)	4.27817237
68	cellular biogenic amine catabolic process (GO:0042402)	4.27231356
69	amine catabolic process (GO:0009310)	4.27231356
70	cholesterol efflux (GO:0033344)	4.26864624
71	glutamate metabolic process (GO:0006536)	4.23527517
72	cellular glucuronidation (GO:0052695)	4.20642079
73	serine family amino acid metabolic process (GO:0009069)	4.16667622
74	negative regulation of protein activation cascade (GO:2000258)	4.14246235
75	benzene-containing compound metabolic process (GO:0042537)	4.10000666
76	ethanol oxidation (GO:0006069)	4.09533428
77	carnitine transmembrane transport (GO:1902603)	4.09325415
78	glycerolipid catabolic process (GO:0046503)	4.07394579
79	arginine metabolic process (GO:0006525)	4.04494704
80	cellular modified amino acid catabolic process (GO:0042219)	4.04281483
81	plasma lipoprotein particle assembly (GO:0034377)	4.03901002
82	dicarboxylic acid biosynthetic process (GO:0043650)	4.02646592
83	fibrinolysis (GO:0042730)	4.01400137
84	low-density lipoprotein particle remodeling (GO:0034374)	4.00540623
85	serine family amino acid biosynthetic process (GO:0009070)	3.99972115
86	aldehyde catabolic process (GO:0046185)	3.97487993
87	amino-acid betaine transport (GO:0015838)	3.94050715
88	carnitine transport (GO:0015879)	3.94050715
89	ketone body metabolic process (GO:1902224)	3.87928658
90	positive regulation of triglyceride lipase activity (GO:0061365)	3.87090856
91	positive regulation of lipoprotein lipase activity (GO:0051006)	3.87090856
92	blood coagulation, intrinsic pathway (GO:0007597)	3.84648951
93	drug catabolic process (GO:0042737)	3.83668721
94	positive regulation of lipid catabolic process (GO:0050996)	3.79794468
95	negative regulation of lipase activity (GO:0060192)	3.78791833
96	cofactor catabolic process (GO:0051187)	3.78732045
97	very-low-density lipoprotein particle assembly (GO:0034379)	3.76013158
98	cholesterol homeostasis (GO:0042632)	3.76002391
99	complement activation, classical pathway (GO:0006958)	3.75411725
100	organic acid catabolic process (GO:0016054)	3.75251315
101	carboxylic acid catabolic process (GO:0046395)	3.75251315
102	phospholipid homeostasis (GO:0055091)	3.74638202
103	uronic acid metabolic process (GO:0006063)	3.72921698
104	glucuronate metabolic process (GO:0019585)	3.72921698
105	complement activation (GO:0006956)	3.70963898
106	regulation of bile acid biosynthetic process (GO:0070857)	3.70879124
107	acetyl-CoA metabolic process (GO:0006084)	3.70482427
108	protein activation cascade (GO:0072376)	3.69946158
109	sterol homeostasis (GO:0055092)	3.69707799
110	cytolysis (GO:0019835)	3.68372943
111	plasma lipoprotein particle organization (GO:0071827)	3.66700178
112	short-chain fatty acid metabolic process (GO:0046459)	3.66033759
113	regulation of cholesterol homeostasis (GO:2000188)	3.64301884
114	protein-lipid complex assembly (GO:0065005)	3.61885459
115	fatty-acyl-CoA metabolic process (GO:0035337)	3.60499399
116	alditol metabolic process (GO:0019400)	3.60323968
117	glycerol metabolic process (GO:0006071)	3.57809890
118	NAD biosynthetic process (GO:0009435)	3.56202559
119	brown fat cell differentiation (GO:0050873)	3.54917856
120	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.54258861
121	triglyceride biosynthetic process (GO:0019432)	3.48197716
122	neutral lipid biosynthetic process (GO:0046460)	3.46787312
123	acylglycerol biosynthetic process (GO:0046463)	3.46787312
124	pantothenate metabolic process (GO:0015939)	3.44600809
125	white fat cell differentiation (GO:0050872)	3.41839244
126	positive regulation of glycolytic process (GO:0045821)	3.41079689
127	triglyceride metabolic process (GO:0006641)	3.37935106
128	folic acid metabolic process (GO:0046655)	3.30490876
129	iron ion import (GO:0097286)	3.29821810
130	thioester biosynthetic process (GO:0035384)	3.27455461
131	acyl-CoA biosynthetic process (GO:0071616)	3.27455461
132	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.26121102
133	acylglycerol metabolic process (GO:0006639)	3.26000650
134	neutral lipid metabolic process (GO:0006638)	3.24987417
135	negative regulation of humoral immune response (GO:0002921)	3.21540938
136	coenzyme A biosynthetic process (GO:0015937)	3.19477787
137	oxaloacetate metabolic process (GO:0006107)	3.17921270
138	quaternary ammonium group transport (GO:0015697)	3.15303457
139	response to growth hormone (GO:0060416)	3.14275357
140	thioester metabolic process (GO:0035383)	3.13923200
141	acyl-CoA metabolic process (GO:0006637)	3.13923200
142	negative regulation of cAMP-mediated signaling (GO:0043951)	3.12452724
143	L-serine metabolic process (GO:0006563)	3.10696331
144	valine metabolic process (GO:0006573)	3.04366900
145	negative regulation of B cell mediated immunity (GO:0002713)	2.90338896
146	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.90338896
147	replicative senescence (GO:0090399)	2.88660481
148	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.86358313
149	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.86358313
150	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	2.85320953
151	primary alcohol metabolic process (GO:0034308)	2.83873245
152	positive regulation of fatty acid oxidation (GO:0046321)	2.81812587
153	coenzyme A metabolic process (GO:0015936)	2.81570361
154	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.80138717
155	branched-chain amino acid metabolic process (GO:0009081)	2.79285527
156	CDP-diacylglycerol biosynthetic process (GO:0016024)	2.75432293
157	citrulline biosynthetic process (GO:0019240)	2.75278238
158	fatty acid catabolic process (GO:0009062)	2.74724384
159	regulation of triglyceride metabolic process (GO:0090207)	2.73960281
160	ethanol metabolic process (GO:0006067)	2.73684137
161	fatty acid beta-oxidation (GO:0006635)	2.72280271
162	alkaloid metabolic process (GO:0009820)	2.71589257
163	fatty acid oxidation (GO:0019395)	2.70689554
164	L-methionine biosynthetic process (GO:0071265)	2.69449866
165	amino acid salvage (GO:0043102)	2.69449866

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	8.39550910
2	PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.19672081
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.98829936
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.49582176
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.29866822
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	5.07345344
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.99112990
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	4.03701521
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.96853470
10	E2F7_22180533_ChIP-Seq_HELA_Human	3.77991220
11	IGF1R_20145208_ChIP-Seq_DFB_Human	3.06186409
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.42054128
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.39722597
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.34042975
15	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.06330040
16	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.02048707
17	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.9499733
18	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.97404488
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85450043
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.81508101
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.79224698
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.63404009
23	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.59973905
24	CLOCK_20551151_ChIP-Seq_293T_Human	1.58098255
25	HTT_18923047_ChIP-ChIP_STHdh_Human	1.54050775
26	EWS_26573619_Chip-Seq_HEK293_Human	1.53433723
27	GATA1_22025678_ChIP-Seq_K562_Human	1.44152435
28	KDM5A_27292631_Chip-Seq_BREAST_Human	1.40445145
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.40100032
30	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.39587562
31	ZNF274_21170338_ChIP-Seq_K562_Hela	1.37453836
32	ERA_21632823_ChIP-Seq_H3396_Human	1.35500011
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.33510514
34	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.33492842
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.33473408
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33243924
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32224186
38	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.29204280
39	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.28397166
40	FUS_26573619_Chip-Seq_HEK293_Human	1.27825624
41	SCL_19346495_ChIP-Seq_HPC-7_Human	1.22724277
42	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.20228753
43	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.19366551
44	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.18853141
45	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.17717363
46	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.16215872
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13242268
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.12989640
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12042277
50	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.10982702
51	CHD1_26751641_Chip-Seq_LNCaP_Human	1.09600601
52	AR_21909140_ChIP-Seq_LNCAP_Human	1.08400625
53	RAC3_21632823_ChIP-Seq_H3396_Human	1.07941595
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07498092
55	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.07071549
56	VDR_22108803_ChIP-Seq_LS180_Human	1.04817073
57	VDR_23849224_ChIP-Seq_CD4+_Human	1.04482333
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04480106
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04480106
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03719339
61	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03157982
62	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02779224
63	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.02226059
64	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01542216
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01482653
66	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.01407770
67	GBX2_23144817_ChIP-Seq_PC3_Human	1.01250346
68	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.99563999
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95746917
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.94241906
71	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.94076749
72	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.92935995
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.92285434
74	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.91652455
75	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.91286997
76	MYC_18940864_ChIP-ChIP_HL60_Human	0.89887777
77	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.89375075
78	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.89028072
79	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.88677778
80	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.88077896
81	TTF2_22483619_ChIP-Seq_HELA_Human	0.86330851
82	TCF4_22108803_ChIP-Seq_LS180_Human	0.85000694
83	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.84549078
84	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.84328776
85	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.83678959
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.83294825
87	PHF8_20622853_ChIP-Seq_HELA_Human	0.81906621
88	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.81720519
89	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.79973136
90	GATA4_25053715_ChIP-Seq_YYC3_Human	0.79582813
91	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.79072909
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.77258743
93	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.77230255
94	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.77027471
95	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.76644501
96	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.76276826
97	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.75976064
98	P300_19829295_ChIP-Seq_ESCs_Human	0.74651805
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.74560181
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.73999585
101	STAT3_23295773_ChIP-Seq_U87_Human	0.73821052
102	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.73738154
103	OCT4_20526341_ChIP-Seq_ESCs_Human	0.73414566
104	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.73389430
105	ZNF263_19887448_ChIP-Seq_K562_Human	0.72555627
106	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.72192257
107	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.71778746
108	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.71602292
109	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.66114319
110	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.66114114
111	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.65711535
112	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.65123420
113	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.64374614
114	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.64374614
115	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.63953536
116	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.63002582
117	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.62930477
118	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.61018982
119	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.59906717
120	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.57816391
121	CEBPB_22108803_ChIP-Seq_LS180_Human	0.57686415
122	LXR_22292898_ChIP-Seq_THP-1_Human	0.55060710
123	EGR1_19032775_ChIP-ChIP_M12_Human	0.54250505
124	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.53091769
125	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.52573205
126	MYC_19915707_ChIP-ChIP_AK7_Human	0.51678816
127	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.51350550
128	AR_20517297_ChIP-Seq_VCAP_Human	0.51190172
129	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.50505956
130	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.49575446
131	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.48402599
132	CBP_21632823_ChIP-Seq_H3396_Human	0.48086800
133	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.47484284
134	STAT1_17558387_ChIP-Seq_HELA_Human	0.46932926
135	P53_21459846_ChIP-Seq_SAOS-2_Human	0.46604777
136	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.45812577
137	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.45159013
138	TAF15_26573619_Chip-Seq_HEK293_Human	0.43555605
139	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.43278851
140	GATA1_19941826_ChIP-Seq_K562_Human	0.43188933
141	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.42907874
142	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.42887643
143	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.42840088
144	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.42486555
145	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.42195569
146	TAF2_19829295_ChIP-Seq_ESCs_Human	0.42143597
147	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.42075269
148	GATA2_19941826_ChIP-Seq_K562_Human	0.40482401
149	BCAT_22108803_ChIP-Seq_LS180_Human	0.40251248
150	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.40240533
151	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.40118982
152	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.38961725
153	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.38808921
154	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.38196726
155	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.37462791
156	GATA6_25053715_ChIP-Seq_YYC3_Human	0.37392458
157	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.36941327
158	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.35914353
159	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.35130790
160	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.34992000
161	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.34364455
162	NCOR_22424771_ChIP-Seq_293T_Human	0.33670553
163	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.33484280
164	ERG_20517297_ChIP-Seq_VCAP_Human	0.33196196
165	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.32913656

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.36350747
2	MP0005360_urolithiasis	7.48869603
3	MP0005085_abnormal_gallbladder_physiolo	6.43708301
4	MP0005365_abnormal_bile_salt	6.19631150
5	MP0008875_abnormal_xenobiotic_pharmacok	5.05921145
6	MP0003806_abnormal_nucleotide_metabolis	4.23171900
7	MP0003252_abnormal_bile_duct	3.90526009
8	MP0004185_abnormal_adipocyte_glucose	3.86982486
9	MP0010329_abnormal_lipoprotein_level	3.63104428
10	MP0009840_abnormal_foam_cell	3.32961743
11	MP0005083_abnormal_biliary_tract	3.06530103
12	MP0003195_calcinosis	2.81569289
13	MP0005375_adipose_tissue_phenotype	2.77378522
14	MP0005332_abnormal_amino_acid	2.75207987
15	MP0001666_abnormal_nutrient_absorption	2.58093589
16	MP0003191_abnormal_cellular_cholesterol	2.36157945
17	MP0008057_abnormal_DNA_replication	2.30031366
18	MP0000609_abnormal_liver_physiology	2.17780457
19	MP0002118_abnormal_lipid_homeostasis	2.13118385
20	MP0004019_abnormal_vitamin_homeostasis	2.11132219
21	MP0002138_abnormal_hepatobiliary_system	1.97319380
22	MP0003868_abnormal_feces_composition	1.92056566
23	MP0005319_abnormal_enzyme/_coenzyme	1.82407156
24	MP0001764_abnormal_homeostasis	1.69356171
25	MP0002009_preneoplasia	1.65786707
26	MP0003646_muscle_fatigue	1.64003739
27	MP0009697_abnormal_copulation	1.59209179
28	MP0002132_abnormal_respiratory_system	1.57436748
29	MP0003959_abnormal_lean_body	1.56892660
30	MP0005584_abnormal_enzyme/coenzyme_acti	1.56275747
31	MP0005451_abnormal_body_composition	1.48719004
32	MP0000003_abnormal_adipose_tissue	1.46883856
33	MP0005551_abnormal_eye_electrophysiolog	1.42045366
34	MP0002909_abnormal_adrenal_gland	1.41207095
35	MP0003011_delayed_dark_adaptation	1.39868854
36	MP0008058_abnormal_DNA_repair	1.38872156
37	MP0003136_yellow_coat_color	1.36915959
38	MP0005452_abnormal_adipose_tissue	1.32434578
39	MP0002638_abnormal_pupillary_reflex	1.30027782
40	MP0005379_endocrine/exocrine_gland_phen	1.29017299
41	MP0003186_abnormal_redox_activity	1.26623744
42	MP0003656_abnormal_erythrocyte_physiolo	1.25044145
43	MP0006138_congestive_heart_failure	1.24033595
44	MP0009643_abnormal_urine_homeostasis	1.22202971
45	MP0005647_abnormal_sex_gland	1.18521231
46	MP0000598_abnormal_liver_morphology	1.17220806
47	MP0003705_abnormal_hypodermis_morpholog	1.16949812
48	MP0002254_reproductive_system_inflammat	1.15348670
49	MP0010094_abnormal_chromosome_stability	1.09803447
50	MP0000604_amyloidosis	1.09134200
51	MP0009764_decreased_sensitivity_to	1.04875834
52	MP0009763_increased_sensitivity_to	1.01432111
53	MP0003693_abnormal_embryo_hatching	1.00480895
54	MP0002160_abnormal_reproductive_system	0.99896731
55	MP0005174_abnormal_tail_pigmentation	0.96303278
56	MP0010368_abnormal_lymphatic_system	0.94092496
57	MP0003879_abnormal_hair_cell	0.93836087
58	MP0005167_abnormal_blood-brain_barrier	0.92635432
59	MP0000569_abnormal_digit_pigmentation	0.91058442
60	MP0005636_abnormal_mineral_homeostasis	0.89939053
61	MP0002876_abnormal_thyroid_physiology	0.89886126
62	MP0008469_abnormal_protein_level	0.88325677
63	MP0009642_abnormal_blood_homeostasis	0.86738957
64	MP0001986_abnormal_taste_sensitivity	0.86474503
65	MP0002277_abnormal_respiratory_mucosa	0.84531974
66	MP0005670_abnormal_white_adipose	0.84199046
67	MP0006036_abnormal_mitochondrial_physio	0.82315163
68	MP0005408_hypopigmentation	0.81778641
69	MP0005376_homeostasis/metabolism_phenot	0.80291834
70	MP0002078_abnormal_glucose_homeostasis	0.78959640
71	MP0009765_abnormal_xenobiotic_induced	0.77742190
72	MP0005377_hearing/vestibular/ear_phenot	0.75579485
73	MP0003878_abnormal_ear_physiology	0.75579485
74	MP0002971_abnormal_brown_adipose	0.75519100
75	MP0005084_abnormal_gallbladder_morpholo	0.75423472
76	MP0001944_abnormal_pancreas_morphology	0.74273828
77	MP0004130_abnormal_muscle_cell	0.72950602
78	MP0005646_abnormal_pituitary_gland	0.72280936
79	MP0003828_pulmonary_edema	0.72010171
80	MP0005334_abnormal_fat_pad	0.71990553
81	MP0004858_abnormal_nervous_system	0.71978460
82	MP0003690_abnormal_glial_cell	0.69931918
83	MP0005220_abnormal_exocrine_pancreas	0.69895554
84	MP0005253_abnormal_eye_physiology	0.69751035
85	MP0005535_abnormal_body_temperature	0.69179016
86	MP0002166_altered_tumor_susceptibility	0.69041596
87	MP0006292_abnormal_olfactory_placode	0.66842400
88	MP0001661_extended_life_span	0.65779415
89	MP0005266_abnormal_metabolism	0.65248751
90	MP0008775_abnormal_heart_ventricle	0.65232549
91	MP0002736_abnormal_nociception_after	0.65204687
92	MP0001968_abnormal_touch/_nociception	0.64328159
93	MP0009053_abnormal_anal_canal	0.63590587
94	MP0003329_amyloid_beta_deposits	0.63435695
95	MP0003698_abnormal_male_reproductive	0.62301076
96	MP0005410_abnormal_fertilization	0.62196243
97	MP0000639_abnormal_adrenal_gland	0.60417208
98	MP0005076_abnormal_cell_differentiation	0.59742061
99	MP0001756_abnormal_urination	0.58952518
100	MP0005448_abnormal_energy_balance	0.57980244
101	MP0005389_reproductive_system_phenotype	0.56511558
102	MP0006035_abnormal_mitochondrial_morpho	0.56452111
103	MP0001919_abnormal_reproductive_system	0.55796988
104	MP0005187_abnormal_penis_morphology	0.55714954
105	MP0001929_abnormal_gametogenesis	0.55672130
106	MP0001501_abnormal_sleep_pattern	0.55340561
107	MP0005464_abnormal_platelet_physiology	0.52642594
108	MP0002822_catalepsy	0.49508661
109	MP0005395_other_phenotype	0.48543184
110	MP0003638_abnormal_response/metabolism_	0.46413022
111	MP0008874_decreased_physiological_sensi	0.45125795
112	MP0002928_abnormal_bile_duct	0.45075231
113	MP0003718_maternal_effect	0.44581301
114	MP0002136_abnormal_kidney_physiology	0.44166021
115	MP0002837_dystrophic_cardiac_calcinosis	0.44084463
116	MP0003724_increased_susceptibility_to	0.43244877
117	MP0008873_increased_physiological_sensi	0.42885328
118	MP0004782_abnormal_surfactant_physiolog	0.42539462
119	MP0005666_abnormal_adipose_tissue	0.42066276
120	MP0003436_decreased_susceptibility_to	0.41326441
121	MP0003075_altered_response_to	0.41258140
122	MP0003953_abnormal_hormone_level	0.41015458
123	MP0004381_abnormal_hair_follicle	0.40596138
124	MP0005248_abnormal_Harderian_gland	0.38524381
125	MP0005166_decreased_susceptibility_to	0.37292832
126	MP0008872_abnormal_physiological_respon	0.36808615
127	MP0009672_abnormal_birth_weight	0.36430925
128	MP0009115_abnormal_fat_cell	0.36137860
129	MP0002796_impaired_skin_barrier	0.35403556
130	MP0006082_CNS_inflammation	0.35095370
131	MP0000579_abnormal_nail_morphology	0.33518233
132	MP0002970_abnormal_white_adipose	0.33198291
133	MP0000249_abnormal_blood_vessel	0.32433920
134	MP0004883_abnormal_blood_vessel	0.32266054
135	MP0002168_other_aberrant_phenotype	0.31830407
136	MP0000230_abnormal_systemic_arterial	0.31518207
137	MP0001243_abnormal_dermal_layer	0.31515397
138	MP0001853_heart_inflammation	0.31409316
139	MP0009384_cardiac_valve_regurgitation	0.30408222
140	MP0001881_abnormal_mammary_gland	0.29344657
141	MP0001845_abnormal_inflammatory_respons	0.27927692
142	MP0005164_abnormal_response_to	0.26008427
143	MP0002060_abnormal_skin_morphology	0.24258739
144	MP0002090_abnormal_vision	0.23817029
145	MP0000427_abnormal_hair_cycle	0.22017140

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.43292874
2	Deep venous thrombosis (HP:0002625)	7.42490776
3	Intrahepatic cholestasis (HP:0001406)	7.29328247
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.68874679
5	Prolonged partial thromboplastin time (HP:0003645)	6.55022795
6	Hypobetalipoproteinemia (HP:0003563)	6.46738378
7	Xanthomatosis (HP:0000991)	6.32752681
8	Hyperlipoproteinemia (HP:0010980)	5.67146467
9	Complement deficiency (HP:0004431)	5.34896814
10	Abnormality of alanine metabolism (HP:0010916)	4.85593472
11	Hyperalaninemia (HP:0003348)	4.85593472
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.85593472
13	Hypolipoproteinemia (HP:0010981)	4.84436712
14	Joint hemorrhage (HP:0005261)	4.80266465
15	Hyperammonemia (HP:0001987)	4.62728390
16	Epidermoid cyst (HP:0200040)	4.53618806
17	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.43661164
18	Hyperglycinemia (HP:0002154)	4.43491818
19	Abnormality of the common coagulation pathway (HP:0010990)	4.42967548
20	Ketosis (HP:0001946)	4.28032784
21	Abnormality of methionine metabolism (HP:0010901)	4.27773228
22	Hypoalphalipoproteinemia (HP:0003233)	4.25728347
23	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.23072009
24	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.11738253
25	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.11738134
26	Fat malabsorption (HP:0002630)	4.11049992
27	Hyperglycinuria (HP:0003108)	3.94369820
28	Abnormality of serine family amino acid metabolism (HP:0010894)	3.93010418
29	Abnormality of glycine metabolism (HP:0010895)	3.93010418
30	Abnormality of complement system (HP:0005339)	3.90186303
31	Hypoglycemic coma (HP:0001325)	3.87337626
32	Abnormality of pyrimidine metabolism (HP:0004353)	3.83020137
33	Abnormality of the intrinsic pathway (HP:0010989)	3.75744511
34	Conjugated hyperbilirubinemia (HP:0002908)	3.67365619
35	Hypercholesterolemia (HP:0003124)	3.63212742
36	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.41503253
37	Abnormality of fatty-acid metabolism (HP:0004359)	3.37330640
38	Hyperbilirubinemia (HP:0002904)	3.32622417
39	Steatorrhea (HP:0002570)	3.10458959
40	Delayed CNS myelination (HP:0002188)	3.09474281
41	Abnormality of serum amino acid levels (HP:0003112)	3.07504832
42	Abnormality of nucleobase metabolism (HP:0010932)	3.04671338
43	Ketoacidosis (HP:0001993)	3.01050825
44	Hypochromic microcytic anemia (HP:0004840)	3.00364238
45	Spontaneous abortion (HP:0005268)	2.99953616
46	Hepatocellular carcinoma (HP:0001402)	2.98190577
47	Myocardial infarction (HP:0001658)	2.95736744
48	Skin nodule (HP:0200036)	2.79742570
49	Metabolic acidosis (HP:0001942)	2.76443487
50	Hypertriglyceridemia (HP:0002155)	2.73568047
51	Systemic lupus erythematosus (HP:0002725)	2.72845300
52	Abnormality of purine metabolism (HP:0004352)	2.65496938
53	Testicular atrophy (HP:0000029)	2.63601708
54	Impulsivity (HP:0100710)	2.60693847
55	Lethargy (HP:0001254)	2.59785796
56	Dicarboxylic aciduria (HP:0003215)	2.59764055
57	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.59764055
58	Congenital stationary night blindness (HP:0007642)	2.59476354
59	Vascular calcification (HP:0004934)	2.54941037
60	Acanthocytosis (HP:0001927)	2.54244465
61	Reduced antithrombin III activity (HP:0001976)	2.53083303
62	Abnormal gallbladder morphology (HP:0012437)	2.50861493
63	Spastic diplegia (HP:0001264)	2.46947743
64	Hypoglycemic seizures (HP:0002173)	2.46782987
65	Cholelithiasis (HP:0001081)	2.45271616
66	Megaloblastic anemia (HP:0001889)	2.42623409
67	Cerebral edema (HP:0002181)	2.41636056
68	Gout (HP:0001997)	2.41169116
69	Mitral stenosis (HP:0001718)	2.41033705
70	Glomerulonephritis (HP:0000099)	2.38917196
71	Increased muscle lipid content (HP:0009058)	2.38084610
72	Cholecystitis (HP:0001082)	2.36851588
73	Abnormal gallbladder physiology (HP:0012438)	2.36851588
74	Recurrent gram-negative bacterial infections (HP:0005420)	2.35756265
75	Oligomenorrhea (HP:0000876)	2.35430578
76	Pigmentary retinal degeneration (HP:0001146)	2.35275359
77	Neonatal onset (HP:0003623)	2.35177830
78	Irritability (HP:0000737)	2.34578425
79	Amyloidosis (HP:0011034)	2.33030945
80	Pancreatic islet-cell hyperplasia (HP:0004510)	2.32398830
81	Malnutrition (HP:0004395)	2.27286658
82	Cardiovascular calcification (HP:0011915)	2.26438001
83	Birth length less than 3rd percentile (HP:0003561)	2.23711708
84	Bile duct proliferation (HP:0001408)	2.20872969
85	Abnormal biliary tract physiology (HP:0012439)	2.20872969
86	Gingival bleeding (HP:0000225)	2.20786758
87	Esophageal varix (HP:0002040)	2.17637515
88	Pancreatitis (HP:0001733)	2.16454827
89	Brushfield spots (HP:0001088)	2.16029377
90	Bony spicule pigmentary retinopathy (HP:0007737)	2.15909059
91	Menorrhagia (HP:0000132)	2.14602004
92	Sensorimotor neuropathy (HP:0007141)	2.14396439
93	Cerebellar dysplasia (HP:0007033)	2.12293632
94	Enlarged kidneys (HP:0000105)	2.11880928
95	Type I transferrin isoform profile (HP:0003642)	2.10937976
96	Late onset (HP:0003584)	2.10459432
97	Abnormality of homocysteine metabolism (HP:0010919)	2.08431709
98	Homocystinuria (HP:0002156)	2.08431709
99	Hyperventilation (HP:0002883)	2.08047231
100	Thrombophlebitis (HP:0004418)	2.07469815
101	Vomiting (HP:0002013)	2.06744460
102	Hypochromic anemia (HP:0001931)	2.05753117
103	Attenuation of retinal blood vessels (HP:0007843)	2.03939174
104	Abnormality of the gallbladder (HP:0005264)	2.03595883
105	Neonatal hypoglycemia (HP:0001998)	2.03298667
106	Increased serum pyruvate (HP:0003542)	2.03001852
107	Poikilocytosis (HP:0004447)	2.02957011
108	Opisthotonus (HP:0002179)	2.02881153
109	Increased serum lactate (HP:0002151)	2.02754437
110	Hemorrhage of the eye (HP:0011885)	2.02663641
111	Generalized aminoaciduria (HP:0002909)	2.01796848
112	Hyperinsulinemic hypoglycemia (HP:0000825)	2.00318612
113	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98940823
114	Acute hepatic failure (HP:0006554)	1.98448988
115	Long foot (HP:0001833)	1.97070367
116	Fair hair (HP:0002286)	1.96037707
117	Rickets (HP:0002748)	1.93864117
118	Hepatic necrosis (HP:0002605)	1.93101342
119	Abnormality of iron homeostasis (HP:0011031)	1.90905973
120	Duplicated collecting system (HP:0000081)	1.90556327
121	Increased CSF lactate (HP:0002490)	1.89371569
122	Abnormal cartilage morphology (HP:0002763)	1.88793462
123	Abnormality of transition element cation homeostasis (HP:0011030)	1.87862974
124	Abnormality of the pons (HP:0007361)	1.87797136
125	Hydroxyprolinuria (HP:0003080)	1.87726352
126	Abnormality of proline metabolism (HP:0010907)	1.87726352
127	Renal cortical cysts (HP:0000803)	1.87126099
128	Toxemia of pregnancy (HP:0100603)	1.85257437
129	Hypophosphatemic rickets (HP:0004912)	1.84687883
130	Retinal atrophy (HP:0001105)	1.83891438
131	Elevated hepatic transaminases (HP:0002910)	1.82084337
132	Methylmalonic aciduria (HP:0012120)	1.81537866
133	Abnormality of glycolysis (HP:0004366)	1.80806131
134	Abnormal enzyme/coenzyme activity (HP:0012379)	1.78902657
135	Status epilepticus (HP:0002133)	1.78695382
136	Lactic acidosis (HP:0003128)	1.78228341
137	Alkalosis (HP:0001948)	1.77873469
138	CNS demyelination (HP:0007305)	1.77208523
139	Pancreatic cysts (HP:0001737)	1.76565973
140	Clitoromegaly (HP:0000057)	1.76505166
141	Amelogenesis imperfecta (HP:0000705)	1.76149726
142	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.76067232
143	Abnormal protein N-linked glycosylation (HP:0012347)	1.76067232
144	Abnormal protein glycosylation (HP:0012346)	1.76067232
145	Abnormal glycosylation (HP:0012345)	1.76067232
146	Acute encephalopathy (HP:0006846)	1.75977503
147	Abnormality of the renal cortex (HP:0011035)	1.75213515
148	Gaze-evoked nystagmus (HP:0000640)	1.75209722
149	Nausea (HP:0002018)	1.75184633
150	Hyperglycemia (HP:0003074)	1.73295078
151	Abnormality of vitamin metabolism (HP:0100508)	1.73135735
152	Reticulocytosis (HP:0001923)	1.71574076
153	Hypoplasia of the pons (HP:0012110)	1.71448323
154	Vaginal fistula (HP:0004320)	1.71304386
155	Limb hypertonia (HP:0002509)	1.71091277
156	Methylmalonic acidemia (HP:0002912)	1.70614920
157	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.65715960

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	7.24900736
2	FGFR4	4.63563515
3	SIK1	4.63409836
4	ERN1	4.41090720
5	PDK2	4.38842071
6	ZAK	3.35306681
7	TAOK3	2.99496784
8	INSRR	2.94463333
9	ERBB4	2.83502378
10	BMPR1B	2.75589594
11	AKT3	2.48622992
12	TNK2	2.37899802
13	MAP2K4	2.33561291
14	RIPK4	2.29021702
15	ACVR1B	2.27470762
16	PKN2	2.26422081
17	WNK4	2.23622638
18	MST1R	2.07748703
19	FLT3	1.92806430
20	TRIB3	1.86511830
21	PIK3CG	1.86509398
22	MAPK11	1.85258943
23	CAMKK2	1.83401470
24	CDC7	1.80213581
25	EEF2K	1.74026132
26	TYK2	1.70282992
27	STK39	1.67683927
28	LATS1	1.59724248
29	BRSK2	1.55424882
30	MAP4K2	1.53579326
31	DAPK2	1.53554491
32	ABL2	1.47128774
33	PTK6	1.46214174
34	CAMK1	1.42316385
35	OXSR1	1.41468735
36	FGFR2	1.40063423
37	NEK9	1.39268291
38	YES1	1.38024662
39	STK16	1.35454187
40	BLK	1.33858926
41	FRK	1.32437505
42	KDR	1.30987760
43	TLK1	1.23560554
44	JAK2	1.23034655
45	MAP3K7	1.19880537
46	PINK1	1.17942628
47	PRKAA2	1.16550883
48	WNK3	1.08984033
49	MAP2K3	1.07752335
50	TBK1	1.07242485
51	NUAK1	1.06740059
52	GRK6	1.06721966
53	MAP3K14	1.06632648
54	MAP3K10	1.03284820
55	JAK1	1.02315239
56	STK11	0.99526036
57	ERBB2	0.98874899
58	MAPK4	0.97430375
59	MAPK15	0.95940628
60	PRKD3	0.93223609
61	PRKCZ	0.91911275
62	FES	0.91407931
63	ATR	0.87891715
64	IRAK4	0.87777254
65	EPHB1	0.87473591
66	ADRBK2	0.84303707
67	CDK6	0.84299931
68	MAP3K3	0.83249330
69	MET	0.82379211
70	TIE1	0.81267229
71	STK38L	0.81147263
72	MAPK12	0.80748810
73	CAMK1D	0.79518051
74	EPHA3	0.79169482
75	FER	0.78566249
76	DYRK3	0.78235985
77	NME1	0.77824275
78	MAP3K11	0.76644786
79	PRKACG	0.76410236
80	CDK3	0.73986965
81	MAPK13	0.73670501
82	MKNK1	0.72991366
83	DYRK1B	0.72788960
84	TEC	0.71636622
85	CSK	0.70437381
86	CAMK2G	0.70102173
87	GSK3A	0.68276198
88	MAP2K6	0.67456750
89	IRAK3	0.67420751
90	ADRBK1	0.67190737
91	RAF1	0.67108052
92	TTK	0.66659070
93	PRKAA1	0.64824338
94	RPS6KA5	0.63524593
95	PIM1	0.61379046
96	FGFR3	0.61002116
97	CHEK2	0.59680218
98	SGK3	0.59417164
99	TGFBR2	0.59255966
100	RIPK1	0.58784342
101	MAPK7	0.56948116
102	IKBKE	0.55873242
103	PTK2	0.55527488
104	SRPK1	0.55109589
105	CSF1R	0.54451010
106	RPS6KB2	0.53990139
107	PDPK1	0.52784721
108	PRKCQ	0.52568234
109	MAPKAPK5	0.49794775
110	CSNK1G1	0.49790148
111	GRK5	0.48286879
112	MAPKAPK3	0.48218454
113	GRK1	0.48112436
114	WNK1	0.46256030
115	AKT1	0.46105208
116	EPHA4	0.46003330
117	EIF2AK1	0.45930639
118	PRKACB	0.45610367
119	TAOK2	0.44246197
120	IGF1R	0.44066995
121	MAP2K1	0.43259193
122	RET	0.43250673
123	PLK3	0.43058298
124	CDK4	0.42390516
125	SGK2	0.41968846
126	MAP3K5	0.41884406
127	MAP3K13	0.40780765
128	ICK	0.40253732
129	CDK7	0.39939298
130	PRKCG	0.39534085
131	ATM	0.39498217
132	PKN1	0.38867514
133	TSSK6	0.38461775
134	MAP3K6	0.37365338
135	AKT2	0.36744549
136	MTOR	0.35767915
137	STK3	0.34230340
138	TAOK1	0.33868932
139	EGFR	0.33358360
140	RPS6KA4	0.33303224
141	PDK1	0.32786016
142	CAMK4	0.31743353
143	PBK	0.31459094
144	PLK1	0.30542082
145	CAMK1G	0.30525309
146	EIF2AK2	0.30224608
147	MAP3K1	0.29655745
148	MKNK2	0.29322618
149	SGK223	0.29121613
150	SGK494	0.29121613
151	HCK	0.29046414
152	LYN	0.29029030
153	CSNK1G2	0.28607523
154	LATS2	0.26799284
155	IRAK1	0.26757399
156	CSNK1G3	0.26699592
157	PRKCA	0.25239770
158	IRAK2	0.24868248
159	MAP2K2	0.21777595
160	ABL1	0.21095485
161	PDK4	0.20243575
162	PDK3	0.20243575
163	PAK3	0.19183277

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.53960238
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.54387562
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.39040218
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.33663005
5	Arginine biosynthesis_Homo sapiens_hsa00220	3.07873241
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.75192171
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.74451146
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.68967617
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.63493628
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.54255273
11	Fatty acid degradation_Homo sapiens_hsa00071	2.51296306
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.40295172
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.23814948
14	Butanoate metabolism_Homo sapiens_hsa00650	2.16145158
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.12054989
16	Peroxisome_Homo sapiens_hsa04146	2.09617233
17	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.99195478
18	Propanoate metabolism_Homo sapiens_hsa00640	1.94899660
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.93667219
20	Histidine metabolism_Homo sapiens_hsa00340	1.92336344
21	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.91312488
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.90985950
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.90791453
24	Fatty acid metabolism_Homo sapiens_hsa01212	1.84285799
25	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.75502014
26	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.74337092
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.74125405
28	beta-Alanine metabolism_Homo sapiens_hsa00410	1.72292782
29	Retinol metabolism_Homo sapiens_hsa00830	1.69805245
30	Caffeine metabolism_Homo sapiens_hsa00232	1.67881355
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.65284030
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.61751203
33	Phenylalanine metabolism_Homo sapiens_hsa00360	1.57029829
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.56615842
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.51662498
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.50404419
37	Bile secretion_Homo sapiens_hsa04976	1.47952664
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.45480736
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.38203539
40	Fatty acid elongation_Homo sapiens_hsa00062	1.37269343
41	Sulfur metabolism_Homo sapiens_hsa00920	1.33912479
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31582696
43	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.26478607
44	Folate biosynthesis_Homo sapiens_hsa00790	1.20757934
45	ABC transporters_Homo sapiens_hsa02010	1.19727952
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.19584557
47	Steroid biosynthesis_Homo sapiens_hsa00100	1.19039243
48	Fat digestion and absorption_Homo sapiens_hsa04975	1.18770749
49	Carbon metabolism_Homo sapiens_hsa01200	1.12691920
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04808286
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.99669589
52	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.99333491
53	Homologous recombination_Homo sapiens_hsa03440	0.98511021
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.97373439
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97038508
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95874639
57	Sulfur relay system_Homo sapiens_hsa04122	0.94611306
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86823510
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.85428890
60	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.83339894
61	Lysine degradation_Homo sapiens_hsa00310	0.80876772
62	RNA polymerase_Homo sapiens_hsa03020	0.77693163
63	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.77563849
64	One carbon pool by folate_Homo sapiens_hsa00670	0.74895757
65	Fanconi anemia pathway_Homo sapiens_hsa03460	0.71125392
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69697838
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69333946
68	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.66894721
69	Glutathione metabolism_Homo sapiens_hsa00480	0.63870765
70	DNA replication_Homo sapiens_hsa03030	0.61835568
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57608617
72	Pentose phosphate pathway_Homo sapiens_hsa00030	0.56641970
73	Purine metabolism_Homo sapiens_hsa00230	0.56437064
74	Non-homologous end-joining_Homo sapiens_hsa03450	0.55929022
75	Mismatch repair_Homo sapiens_hsa03430	0.52798889
76	Base excision repair_Homo sapiens_hsa03410	0.48437014
77	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.47400718
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46525006
79	Metabolic pathways_Homo sapiens_hsa01100	0.45842898
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.41908100
81	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.39966719
82	Prion diseases_Homo sapiens_hsa05020	0.36961768
83	Basal transcription factors_Homo sapiens_hsa03022	0.28994283
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.27700576
85	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.26361151
86	Galactose metabolism_Homo sapiens_hsa00052	0.25198806
87	Insulin resistance_Homo sapiens_hsa04931	0.23651488
88	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.23395007
89	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.22669524
90	Linoleic acid metabolism_Homo sapiens_hsa00591	0.22587838
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.19016880
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.17317816
93	Glucagon signaling pathway_Homo sapiens_hsa04922	0.10316876
94	AMPK signaling pathway_Homo sapiens_hsa04152	0.03042255
95	Ether lipid metabolism_Homo sapiens_hsa00565	-0.2361576
96	Amoebiasis_Homo sapiens_hsa05146	-0.2349147
97	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.2348457
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	-0.2320068
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.2293072
100	Renin-angiotensin system_Homo sapiens_hsa04614	-0.2027567
101	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.1988060
102	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1952462
103	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1951942
104	Hepatitis C_Homo sapiens_hsa05160	-0.1820674
105	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1569857
106	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1548660
107	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1536871
108	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1488970
109	Regulation of autophagy_Homo sapiens_hsa04140	-0.1400097
110	African trypanosomiasis_Homo sapiens_hsa05143	-0.1308253
111	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0946041
112	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0837020
113	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.0795281
114	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0716329
115	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0344033

MARC1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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