MARCH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)5.77816563
2positive regulation of gamma-delta T cell activation (GO:0046645)5.73518992
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.30229712
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.30229712
5modulation by symbiont of host immune response (GO:0052553)5.30229712
6positive regulation by symbiont of host defense response (GO:0052509)5.30229712
7modulation by symbiont of host defense response (GO:0052031)5.30229712
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.30229712
9macrophage activation involved in immune response (GO:0002281)5.22142883
10regulation of B cell receptor signaling pathway (GO:0050855)5.02405951
11G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.90199435
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67953013
13detection of molecule of bacterial origin (GO:0032490)4.45578305
14negative regulation of interleukin-12 production (GO:0032695)4.40047270
15detection of other organism (GO:0098543)4.37189244
16neutrophil activation involved in immune response (GO:0002283)4.23365336
17regulation of interferon-beta biosynthetic process (GO:0045357)4.21120824
18macrophage activation (GO:0042116)4.11013419
19detection of external biotic stimulus (GO:0098581)4.02856728
20detection of bacterium (GO:0016045)3.98072870
21respiratory burst (GO:0045730)3.94545144
22regulation of gamma-delta T cell activation (GO:0046643)3.92339499
23positive regulation of cellular amide metabolic process (GO:0034250)3.85626064
24immunoglobulin mediated immune response (GO:0016064)3.82714395
25response to peptidoglycan (GO:0032494)3.80978983
26positive regulation of interferon-alpha production (GO:0032727)3.70104349
27response to host immune response (GO:0052572)3.63479818
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.63479818
29positive regulation of mast cell activation involved in immune response (GO:0033008)3.57255269
30positive regulation of mast cell degranulation (GO:0043306)3.57255269
31eosinophil chemotaxis (GO:0048245)3.55498596
32G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.55070088
33myeloid cell activation involved in immune response (GO:0002275)3.54512023
34detection of biotic stimulus (GO:0009595)3.54438027
35B cell receptor signaling pathway (GO:0050853)3.53896432
36regulation of interferon-alpha production (GO:0032647)3.53516266
37antigen processing and presentation of endogenous antigen (GO:0019883)3.51512558
38negative regulation of cell killing (GO:0031342)3.45399095
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45399095
40granulocyte activation (GO:0036230)3.43147159
41T-helper 1 type immune response (GO:0042088)3.37978549
42neutrophil activation (GO:0042119)3.34895261
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30030757
44response to host (GO:0075136)3.29825465
45response to host defenses (GO:0052200)3.29825465
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.29825465
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28822331
48regulation of T-helper 2 cell differentiation (GO:0045628)3.28699014
49positive regulation of mast cell activation (GO:0033005)3.24649616
50regulation of mast cell degranulation (GO:0043304)3.23965149
51positive regulation of antigen processing and presentation (GO:0002579)3.20420428
52regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19850128
53negative regulation of T cell mediated immunity (GO:0002710)3.18688051
54negative regulation of lymphocyte mediated immunity (GO:0002707)3.17170482
55eosinophil migration (GO:0072677)3.14542343
56neutrophil mediated immunity (GO:0002446)3.13321827
57purinergic nucleotide receptor signaling pathway (GO:0035590)3.09164197
58regulation of gamma-delta T cell differentiation (GO:0045586)3.08002997
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05667224
60activated T cell proliferation (GO:0050798)3.05338315
61regulation of mast cell activation involved in immune response (GO:0033006)3.02210823
62cellular response to ethanol (GO:0071361)3.00721471
63regulation of mast cell activation (GO:0033003)2.99753887
64positive regulation of monocyte chemotaxis (GO:0090026)2.99032056
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97305506
66phagosome maturation (GO:0090382)2.96691695
67positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.96366584
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.95364512
69regulation of hypersensitivity (GO:0002883)2.95118281
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94365640
71myeloid leukocyte mediated immunity (GO:0002444)2.93732177
72cellular extravasation (GO:0045123)2.93647264
73superoxide anion generation (GO:0042554)2.90938755
74cellular response to zinc ion (GO:0071294)2.89134243
75negative regulation of mast cell activation (GO:0033004)2.88263826
76interferon-gamma-mediated signaling pathway (GO:0060333)2.87327814
77regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.86873943
78defense response to protozoan (GO:0042832)2.85815245
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84081780
80regulation of type 2 immune response (GO:0002828)2.83852315
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.82332363
82positive regulation of chemokine biosynthetic process (GO:0045080)2.82222605
83positive regulation of interleukin-1 beta secretion (GO:0050718)2.81913808
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81895959
85positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.80274841
86myeloid leukocyte activation (GO:0002274)2.79410775
87regulation of B cell differentiation (GO:0045577)2.79322346
88regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78297488
89positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.77925486
90adenosine receptor signaling pathway (GO:0001973)2.77844254
91cellular response to interferon-gamma (GO:0071346)2.77198299
92type I interferon signaling pathway (GO:0060337)2.75506375
93cellular response to type I interferon (GO:0071357)2.75506375
94negative regulation of leukocyte mediated immunity (GO:0002704)2.75354618
95regulation of monocyte chemotaxis (GO:0090025)2.73579292
96T cell migration (GO:0072678)2.73023402
97germinal center formation (GO:0002467)2.72081828
98positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.71560372
99positive regulation of macrophage cytokine production (GO:0060907)2.71170716
100response to type I interferon (GO:0034340)2.71149457
101positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70899297
102regulation of myeloid leukocyte mediated immunity (GO:0002886)2.69783010
103interferon-gamma production (GO:0032609)2.69232143
104regulation of T cell tolerance induction (GO:0002664)2.69128275
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68960772
106antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.68581976
107neutrophil chemotaxis (GO:0030593)2.67124698
108purinergic receptor signaling pathway (GO:0035587)2.66403798
109negative regulation of B cell proliferation (GO:0030889)2.66246497
110regulation of platelet aggregation (GO:0090330)2.61218680
111positive regulation of toll-like receptor signaling pathway (GO:0034123)2.60688877
112regulation of leukocyte degranulation (GO:0043300)2.60052200
113I-kappaB phosphorylation (GO:0007252)2.59644270
114neutrophil migration (GO:1990266)2.59010740
115granulocyte chemotaxis (GO:0071621)2.58839976
116hydrogen peroxide biosynthetic process (GO:0050665)2.58503721
117positive regulation of type 2 immune response (GO:0002830)2.58066544
118mast cell activation (GO:0045576)2.57667161
119regulation of antigen processing and presentation (GO:0002577)2.57258157
120monocyte chemotaxis (GO:0002548)2.57068096
121regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55786211
122response to muramyl dipeptide (GO:0032495)2.51521021
123positive regulation of leukocyte degranulation (GO:0043302)2.51139738
124regulation of interferon-gamma biosynthetic process (GO:0045072)2.47409417
125granulocyte migration (GO:0097530)2.46828934
126positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46385721
127presynaptic membrane assembly (GO:0097105)2.46243368
128neuron cell-cell adhesion (GO:0007158)2.46113717
129histamine secretion (GO:0001821)2.46015227
130positive regulation of interferon-beta production (GO:0032728)2.45833687
131B cell proliferation (GO:0042100)2.45777160
132response to protozoan (GO:0001562)2.43074868
133B cell mediated immunity (GO:0019724)2.42656913
134glycosphingolipid catabolic process (GO:0046479)2.39951683
135negative regulation of interleukin-17 production (GO:0032700)2.38958620
136production of molecular mediator involved in inflammatory response (GO:0002532)2.38795830
137regulation of glutamate receptor signaling pathway (GO:1900449)2.37630752
138positive regulation of B cell differentiation (GO:0045579)2.37205125
139leukocyte mediated cytotoxicity (GO:0001909)2.35865720
140lymphocyte chemotaxis (GO:0048247)2.34613356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.06299535
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.52681803
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.22812119
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.63118919
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22628488
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10859504
7GBX2_23144817_ChIP-Seq_PC3_Human2.65847876
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.64319554
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.53287403
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.50963253
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.43632154
12EZH2_22144423_ChIP-Seq_EOC_Human2.35846328
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32774742
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08871435
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03622400
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98894475
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96230441
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91148797
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.86465073
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72297288
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72078012
22MYB_26560356_Chip-Seq_TH2_Human1.70092321
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66643750
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65967497
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59221240
26RUNX_20019798_ChIP-Seq_JUKART_Human1.58254303
27VDR_24787735_ChIP-Seq_THP-1_Human1.58036693
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54691463
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50005636
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49473546
31GATA3_27048872_Chip-Seq_THYMUS_Human1.46683199
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46584969
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45212387
34DROSHA_22980978_ChIP-Seq_HELA_Human1.42061503
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41186023
36TAF15_26573619_Chip-Seq_HEK293_Human1.40978874
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38806671
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37484554
39VDR_24763502_ChIP-Seq_THP-1_Human1.36948819
40SPI1_23127762_ChIP-Seq_K562_Human1.36031461
41GATA3_26560356_Chip-Seq_TH2_Human1.34486258
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34339526
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33935167
44AR_21572438_ChIP-Seq_LNCaP_Human1.32780048
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32619561
46P300_19829295_ChIP-Seq_ESCs_Human1.32508808
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31526211
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30799993
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27852492
50VDR_22108803_ChIP-Seq_LS180_Human1.25288165
51SMAD4_21799915_ChIP-Seq_A2780_Human1.25099286
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24882787
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24818531
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22863159
55MYB_26560356_Chip-Seq_TH1_Human1.22332829
56EGR1_19032775_ChIP-ChIP_M12_Human1.22331352
57REST_21632747_ChIP-Seq_MESCs_Mouse1.21136305
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18847852
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18122105
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16782934
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15488289
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14909040
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.14873136
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.13619533
65PU_27001747_Chip-Seq_BMDM_Mouse1.12194608
66GATA1_22025678_ChIP-Seq_K562_Human1.11908836
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11119435
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10310319
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08823425
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07735893
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07735893
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.07320751
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07247153
74TP53_16413492_ChIP-PET_HCT116_Human1.06618054
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06219503
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05864390
77AR_25329375_ChIP-Seq_VCAP_Human1.05731758
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05618925
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04285409
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.03326235
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03169606
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03169606
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02263397
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01237097
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.00538100
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00410697
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00410697
88RNF2_27304074_Chip-Seq_ESCs_Mouse0.99976122
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99079385
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99070002
91SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99011788
92MAF_26560356_Chip-Seq_TH1_Human0.98940785
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98402719
94SMRT_27268052_Chip-Seq_Bcells_Human0.97495050
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.95179247
96NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94331521
97CMYC_18555785_Chip-Seq_ESCs_Mouse0.93957935
98SPI1_23547873_ChIP-Seq_NB4_Human0.93382328
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.93380180
100SCL_19346495_ChIP-Seq_HPC-7_Human0.93289704
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.92910435
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92713585
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92612734
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.92609944
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92580578
106E2F1_18555785_Chip-Seq_ESCs_Mouse0.92248486
107CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92147598
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92051700
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91634820
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90604283
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90430885
112EED_16625203_ChIP-ChIP_MESCs_Mouse0.90259693
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89508141
114TP53_18474530_ChIP-ChIP_U2OS_Human0.88555270
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88286856
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87948101
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87132889
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87074765
119P53_22387025_ChIP-Seq_ESCs_Mouse0.86946508
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86821811
121AHR_22903824_ChIP-Seq_MCF-7_Human0.86698093
122RXR_22108803_ChIP-Seq_LS180_Human0.86530457
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86051504
124PU1_27457419_Chip-Seq_LIVER_Mouse0.85997153
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85989876
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83749754
127ER_23166858_ChIP-Seq_MCF-7_Human0.82353270
128KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.82082860
129VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81290011
130FLI1_21867929_ChIP-Seq_TH2_Mouse0.80182873
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80161612
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.79651528
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78911955
134GATA2_19941826_ChIP-Seq_K562_Human0.78535023
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78143972
136EGR1_19374776_ChIP-ChIP_THP-1_Human0.78041662
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.78019899
138GATA1_19941826_ChIP-Seq_K562_Human0.77908053
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.77248338
140BCAT_22108803_ChIP-Seq_LS180_Human0.77000769
141UTX_26944678_Chip-Seq_JUKART_Human0.76721807
142OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75972070
143PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74155490
144GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73887482
145VDR_21846776_ChIP-Seq_THP-1_Human0.72973673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.51302748
2MP0003303_peritoneal_inflammation3.74454131
3MP0006082_CNS_inflammation3.36456211
4MP0002148_abnormal_hypersensitivity_rea3.19661131
5MP0005000_abnormal_immune_tolerance2.83844689
6MP0002419_abnormal_innate_immunity2.82891923
7MP0005387_immune_system_phenotype2.79534146
8MP0001790_abnormal_immune_system2.79534146
9MP0005671_abnormal_response_to2.72932903
10MP0003436_decreased_susceptibility_to2.68975192
11MP0003880_abnormal_central_pattern2.67358177
12MP0009785_altered_susceptibility_to2.65778054
13MP0004859_abnormal_synaptic_plasticity2.65096020
14MP0001800_abnormal_humoral_immune2.63113516
15* MP0002452_abnormal_antigen_presenting2.56715037
16MP0004510_myositis2.48625529
17MP0003690_abnormal_glial_cell2.44797779
18MP0005058_abnormal_lysosome_morphology2.41122845
19MP0005025_abnormal_response_to2.27049575
20* MP0002723_abnormal_immune_serum2.23050102
21MP0003191_abnormal_cellular_cholesterol2.05570588
22* MP0001819_abnormal_immune_cell2.04076695
23* MP0002420_abnormal_adaptive_immunity2.02882991
24MP0003075_altered_response_to1.97297796
25MP0003300_gastrointestinal_ulcer1.96893151
26MP0003724_increased_susceptibility_to1.95238322
27MP0003172_abnormal_lysosome_physiology1.93892324
28MP0005464_abnormal_platelet_physiology1.80591237
29MP0005310_abnormal_salivary_gland1.78787469
30MP0000685_abnormal_immune_system1.74026038
31MP0000569_abnormal_digit_pigmentation1.66806228
32MP0003183_abnormal_peptide_metabolism1.64693849
33MP0002064_seizures1.60267892
34MP0003635_abnormal_synaptic_transmissio1.59832036
35MP0005166_decreased_susceptibility_to1.57187706
36MP0001533_abnormal_skeleton_physiology1.53720578
37MP0005397_hematopoietic_system_phenotyp1.51590510
38MP0001545_abnormal_hematopoietic_system1.51590510
39MP0005423_abnormal_somatic_nervous1.50031822
40MP0001968_abnormal_touch/_nociception1.49998919
41MP0009745_abnormal_behavioral_response1.48676701
42MP0002736_abnormal_nociception_after1.48651872
43MP0000604_amyloidosis1.47034204
44MP0009278_abnormal_bone_marrow1.43732461
45MP0009764_decreased_sensitivity_to1.43682713
46MP0001845_abnormal_inflammatory_respons1.42673554
47MP0002063_abnormal_learning/memory/cond1.42571280
48MP0008260_abnormal_autophagy1.42562619
49MP0002405_respiratory_system_inflammati1.39374591
50MP0005551_abnormal_eye_electrophysiolog1.37627238
51MP0000920_abnormal_myelination1.34548915
52MP0001853_heart_inflammation1.32712606
53* MP0000716_abnormal_immune_system1.30678178
54MP0001501_abnormal_sleep_pattern1.30529342
55MP0000465_gastrointestinal_hemorrhage1.26551806
56MP0002822_catalepsy1.26396892
57MP0009046_muscle_twitch1.26305028
58MP0002572_abnormal_emotion/affect_behav1.24829521
59MP0002998_abnormal_bone_remodeling1.24108267
60MP0004270_analgesia1.23649398
61MP0003763_abnormal_thymus_physiology1.21570979
62MP0003656_abnormal_erythrocyte_physiolo1.21170367
63MP0002090_abnormal_vision1.20770328
64MP0001486_abnormal_startle_reflex1.19083903
65MP0002735_abnormal_chemical_nociception1.18811195
66MP0004883_abnormal_blood_vessel1.18741159
67MP0000343_altered_response_to1.18478670
68MP0005164_abnormal_response_to1.17913335
69MP0001440_abnormal_grooming_behavior1.15179186
70MP0005167_abnormal_blood-brain_barrier1.15159336
71MP0008469_abnormal_protein_level1.15048479
72MP0003633_abnormal_nervous_system1.12699412
73MP0002332_abnormal_exercise_endurance1.10873931
74MP0005451_abnormal_body_composition1.09389777
75MP0002398_abnormal_bone_marrow1.08567398
76MP0002277_abnormal_respiratory_mucosa1.07049706
77MP0001851_eye_inflammation1.04859520
78MP0003866_abnormal_defecation1.04165395
79MP0001986_abnormal_taste_sensitivity0.96354239
80MP0004947_skin_inflammation0.96332019
81MP0009840_abnormal_foam_cell0.95902250
82MP0002067_abnormal_sensory_capabilities0.95315484
83MP0000689_abnormal_spleen_morphology0.94805801
84MP0008004_abnormal_stomach_pH0.94339902
85MP0005253_abnormal_eye_physiology0.93692024
86MP0004742_abnormal_vestibular_system0.91056349
87* MP0002429_abnormal_blood_cell0.90804798
88MP0002006_tumorigenesis0.90363457
89MP0002638_abnormal_pupillary_reflex0.89810650
90MP0003634_abnormal_glial_cell0.88931431
91MP0003448_altered_tumor_morphology0.88916334
92MP0003787_abnormal_imprinting0.88721331
93MP0009333_abnormal_splenocyte_physiolog0.86887367
94MP0008874_decreased_physiological_sensi0.86264539
95MP0000015_abnormal_ear_pigmentation0.83029048
96MP0003329_amyloid_beta_deposits0.82617838
97MP0001970_abnormal_pain_threshold0.81703948
98MP0003631_nervous_system_phenotype0.81036754
99MP0002272_abnormal_nervous_system0.80912577
100MP0005646_abnormal_pituitary_gland0.79367377
101MP0000858_altered_metastatic_potential0.79326074
102MP0010155_abnormal_intestine_physiology0.78462555
103MP0002733_abnormal_thermal_nociception0.78297122
104MP0002229_neurodegeneration0.77349189
105MP0004858_abnormal_nervous_system0.77174774
106MP0009763_increased_sensitivity_to0.76641174
107MP0003045_fibrosis0.76596891
108MP0000371_diluted_coat_color0.75811883
109MP0003828_pulmonary_edema0.75474445
110MP0000778_abnormal_nervous_system0.75219108
111MP0005174_abnormal_tail_pigmentation0.74065411
112MP0002734_abnormal_mechanical_nocicepti0.73929399
113MP0005386_behavior/neurological_phenoty0.73666646
114MP0004924_abnormal_behavior0.73666646
115MP0002138_abnormal_hepatobiliary_system0.73195567
116MP0001663_abnormal_digestive_system0.71988903
117MP0003221_abnormal_cardiomyocyte_apopto0.71718380
118MP0002166_altered_tumor_susceptibility0.70593241
119MP0003011_delayed_dark_adaptation0.69879702
120MP0002722_abnormal_immune_system0.69284988
121MP0004811_abnormal_neuron_physiology0.68195939
122MP0003195_calcinosis0.66637845
123MP0000249_abnormal_blood_vessel0.66347578
124MP0004381_abnormal_hair_follicle0.65875961
125MP0000703_abnormal_thymus_morphology0.65734104
126MP0003632_abnormal_nervous_system0.64696984
127MP0009765_abnormal_xenobiotic_induced0.63650954
128MP0005075_abnormal_melanosome_morpholog0.62448084
129MP0005535_abnormal_body_temperature0.59753900
130MP0002009_preneoplasia0.58707652
131MP0006054_spinal_hemorrhage0.57844730
132MP0003091_abnormal_cell_migration0.56385080
133MP0008877_abnormal_DNA_methylation0.56274691
134MP0004130_abnormal_muscle_cell0.55870315

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.81765078
2Recurrent bacterial skin infections (HP:0005406)6.56197934
3Eczematoid dermatitis (HP:0000976)5.74480375
4Recurrent gram-negative bacterial infections (HP:0005420)5.06542344
5Systemic lupus erythematosus (HP:0002725)4.94982854
6Mediastinal lymphadenopathy (HP:0100721)4.37294087
7Glomerulonephritis (HP:0000099)4.04920174
8Recurrent skin infections (HP:0001581)3.89803069
9Abnormality of liposaccharide metabolism (HP:0010968)3.81369181
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.81369181
11Abnormality of glycolipid metabolism (HP:0010969)3.81369181
12Disinhibition (HP:0000734)3.78700226
13Abnormality of macrophages (HP:0004311)3.74905302
14Chronic obstructive pulmonary disease (HP:0006510)3.51770385
15Obstructive lung disease (HP:0006536)3.51770385
16Increased cerebral lipofuscin (HP:0011813)3.48846139
17Stomatitis (HP:0010280)3.43721439
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.33587290
19Gingivitis (HP:0000230)3.31924376
20Cellulitis (HP:0100658)3.20647971
21Hemoptysis (HP:0002105)3.20631118
22Congenital stationary night blindness (HP:0007642)3.20314743
23Agammaglobulinemia (HP:0004432)3.20069017
24Prostate neoplasm (HP:0100787)3.13738389
25Gastrointestinal stroma tumor (HP:0100723)3.12697375
26Mutism (HP:0002300)3.12615537
27T lymphocytopenia (HP:0005403)3.10216609
28Keratoconjunctivitis sicca (HP:0001097)3.09693114
29Inappropriate behavior (HP:0000719)3.09247067
30Vasculitis (HP:0002633)3.03122844
31Encephalitis (HP:0002383)2.99441929
32Recurrent fungal infections (HP:0002841)2.95932340
33Gastrointestinal infarctions (HP:0005244)2.91373130
34Keratoconjunctivitis (HP:0001096)2.89589584
35Abnormality of T cell number (HP:0011839)2.88661768
36Recurrent pneumonia (HP:0006532)2.88287246
37Colitis (HP:0002583)2.83924505
38Meningitis (HP:0001287)2.83392505
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.81500669
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.77913535
41Agnosia (HP:0010524)2.72818775
42Focal motor seizures (HP:0011153)2.72796862
43Recurrent viral infections (HP:0004429)2.71891595
44Epileptic encephalopathy (HP:0200134)2.66521210
45Recurrent cutaneous fungal infections (HP:0011370)2.65360599
46Chronic mucocutaneous candidiasis (HP:0002728)2.65360599
47Chest pain (HP:0100749)2.63896978
48Vacuolated lymphocytes (HP:0001922)2.62103267
49Neurofibrillary tangles (HP:0002185)2.61982291
50Myositis (HP:0100614)2.59733899
51Progressive visual loss (HP:0000529)2.54445946
52Dysostosis multiplex (HP:0000943)2.53886395
53Orchitis (HP:0100796)2.52436984
54Recurrent sinusitis (HP:0011108)2.51066985
55Papilledema (HP:0001085)2.50519373
56Autoimmune thrombocytopenia (HP:0001973)2.49781241
57Amyloidosis (HP:0011034)2.49424059
58Pulmonary embolism (HP:0002204)2.48088722
59Leukocytosis (HP:0001974)2.47918246
60Osteomyelitis (HP:0002754)2.46701795
61Febrile seizures (HP:0002373)2.44682911
62Recurrent lower respiratory tract infections (HP:0002783)2.44210092
63Panhypogammaglobulinemia (HP:0003139)2.42394957
64Retrobulbar optic neuritis (HP:0100654)2.41624296
65Optic neuritis (HP:0100653)2.41624296
66Complement deficiency (HP:0004431)2.41581586
67Pulmonary infiltrates (HP:0002113)2.41469939
68Elevated erythrocyte sedimentation rate (HP:0003565)2.40442343
69Thick nail (HP:0001805)2.39998944
70Increased IgM level (HP:0003496)2.38480678
71Arterial thrombosis (HP:0004420)2.37071318
72Supranuclear gaze palsy (HP:0000605)2.37026825
73Axonal loss (HP:0003447)2.36339812
74Chronic diarrhea (HP:0002028)2.30476078
75Gingival bleeding (HP:0000225)2.30375122
76Abnormality of the pleura (HP:0002103)2.29416245
77Inflammation of the large intestine (HP:0002037)2.28465675
78Memory impairment (HP:0002354)2.25326892
79Gangrene (HP:0100758)2.25069874
80Hematochezia (HP:0002573)2.20903710
81Neuronal loss in central nervous system (HP:0002529)2.19638091
82J-shaped sella turcica (HP:0002680)2.19196910
83Nephritis (HP:0000123)2.18630871
84Prolonged bleeding time (HP:0003010)2.16231322
85Basal ganglia calcification (HP:0002135)2.15736138
86Cerebral inclusion bodies (HP:0100314)2.14713399
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11594922
88Polyneuropathy (HP:0001271)2.10907256
89Epistaxis (HP:0000421)2.10547304
90Retinal atrophy (HP:0001105)2.10418027
91Abnormality of complement system (HP:0005339)2.09159322
92Sepsis (HP:0100806)2.08871109
93Lymphopenia (HP:0001888)2.08592849
94Choroideremia (HP:0001139)2.08512883
95Vertigo (HP:0002321)2.08030794
96Gastrointestinal inflammation (HP:0004386)2.08015457
97Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07866128
98Amyotrophic lateral sclerosis (HP:0007354)2.06413079
99Thyroiditis (HP:0100646)2.05418148
100Episodic fever (HP:0001954)2.01929162
101Pustule (HP:0200039)2.01910304
102Agitation (HP:0000713)2.00060977
103Pigmentary retinal degeneration (HP:0001146)1.99830160
104Urticaria (HP:0001025)1.97791550
105Restrictive lung disease (HP:0002091)1.97570300
106Hemiplegia (HP:0002301)1.97410052
107Hyperventilation (HP:0002883)1.97364653
108Anorexia (HP:0002039)1.96384639
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95640461
110Loss of speech (HP:0002371)1.95342235
111Urethral obstruction (HP:0000796)1.95281905
112Interstitial pulmonary disease (HP:0006530)1.95199587
113Abnormality of cells of the lymphoid lineage (HP:0012140)1.95113038
114Abnormality of the prostate (HP:0008775)1.94314393
115Abnormality of T cells (HP:0002843)1.93010550
116Apathy (HP:0000741)1.92294853
117Dyschromatopsia (HP:0007641)1.92189149
118Focal seizures (HP:0007359)1.91604590
119Excessive salivation (HP:0003781)1.89919584
120Drooling (HP:0002307)1.89919584
121Global brain atrophy (HP:0002283)1.86929255
122Recurrent bronchitis (HP:0002837)1.86378484
123Upper motor neuron abnormality (HP:0002127)1.86196111
124Periodontitis (HP:0000704)1.85130587
125Bony spicule pigmentary retinopathy (HP:0007737)1.83506681
126Viral hepatitis (HP:0006562)1.81897415
127Abnormal rod and cone electroretinograms (HP:0008323)1.81721025
128Keratitis (HP:0000491)1.81308496
129Abnormality of salivation (HP:0100755)1.81280643
130Abolished electroretinogram (ERG) (HP:0000550)1.80559314
131Abnormality of polysaccharide metabolism (HP:0011012)1.79825099
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79825099
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79825099
134Emphysema (HP:0002097)1.79475257
135Glomerulopathy (HP:0100820)1.78614912
136Abnormality of binocular vision (HP:0011514)1.76264738
137Diplopia (HP:0000651)1.76264738
138Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75694538
139Spontaneous hematomas (HP:0007420)1.75109552
140Chronic sinusitis (HP:0011109)1.74644088
141Diminished motivation (HP:0000745)1.74400874
142IgM deficiency (HP:0002850)1.74322445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.83070862
2BLK3.46385678
3MAP3K142.91286379
4GRK72.73838333
5MAP4K12.64508014
6TYK22.58186016
7CASK2.55380813
8TGFBR22.28237458
9MAP3K92.18690931
10MARK12.12016304
11PBK1.96622078
12BMPR21.93607115
13IRAK41.92784823
14CSF1R1.82699970
15FGR1.77211004
16NTRK31.76120910
17JAK11.72908679
18SYK1.72219233
19TBK11.67861356
20MAP3K131.64899668
21TXK1.64747166
22IRAK31.60103116
23SIK21.57876279
24FRK1.54826365
25IKBKB1.54467453
26MAP3K121.49322416
27FES1.44080561
28EPHA41.38033381
29LYN1.35384739
30MAP2K31.34426701
31DAPK21.31203314
32KIT1.30594955
33GRK11.28751225
34HCK1.20657413
35PLK21.19518775
36NEK91.18707976
37GRK51.17947353
38TNK21.17013660
39IKBKE1.16297310
40SIK31.15588398
41CSK1.15441182
42PDK21.14808048
43MATK1.09870533
44MAP2K71.08863362
45CLK11.07783581
46ITK1.06647991
47PIK3CG1.05246109
48PRPF4B1.05187106
49IRAK11.03744084
50ARAF1.01278641
51MAPK71.00616980
52MAPK120.99285821
53ERN10.98825473
54EPHA30.92957986
55PDK10.91377337
56MAP4K20.90767957
57IRAK20.90485141
58ADRBK20.90363027
59MARK20.90131659
60MAPK130.89060958
61MARK30.86919362
62MINK10.85799934
63ERBB30.85414077
64PKN10.80877641
65MAP3K20.80098386
66LCK0.79604554
67CAMKK10.78677742
68EIF2AK20.77008554
69TAOK10.76800183
70ACVR1B0.75256833
71MAP3K50.74798252
72YES10.74467318
73EPHB10.74021164
74MAP3K10.72432454
75MOS0.72096770
76BMPR1B0.71782320
77PRKCQ0.71675902
78CHUK0.70365830
79FYN0.69382848
80GRK60.69333609
81JAK20.68328904
82PDPK10.68259446
83MAP3K60.66933604
84CDK50.66591892
85NEK60.66441934
86PAK60.66037860
87KSR10.64640329
88DAPK10.62322885
89MAP3K110.61796901
90MAP3K30.61680115
91CDC42BPA0.60176724
92SGK30.59373672
93DYRK1B0.58287343
94KSR20.57556772
95PRKCH0.57021480
96CDK190.56193188
97PRKCD0.56188868
98BTK0.55892849
99CAMK1G0.55298672
100EGFR0.53913753
101TEC0.53724411
102SGK20.53356844
103MAP3K40.51430775
104PIM10.50763458
105NTRK20.49026321
106PRKCZ0.47837897
107CAMK1D0.46705421
108DYRK30.46397016
109CCNB10.45654929
110FGFR30.45472872
111SGK10.45075281
112CDK60.44708070
113ABL10.44489271
114MAP2K40.42724536
115CAMK40.41732535
116CAMKK20.41395421
117PRKCE0.41315077
118PTK2B0.41025682
119ZAP700.40288535
120TNIK0.40088996
121TAOK30.39045841
122JAK30.38702184
123OXSR10.38700904
124STK110.37838050
125SGK2230.36408832
126SGK4940.36408832
127CAMK2A0.35855144
128DYRK1A0.35329786
129STK100.34399847
130NLK0.33935710

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.87686577
2Leishmaniasis_Homo sapiens_hsa051402.49530899
3Phototransduction_Homo sapiens_hsa047442.38863042
4B cell receptor signaling pathway_Homo sapiens_hsa046622.34545590
5Osteoclast differentiation_Homo sapiens_hsa043802.16841387
6Tuberculosis_Homo sapiens_hsa051522.02194139
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01150140
8Pertussis_Homo sapiens_hsa051331.88293162
9Graft-versus-host disease_Homo sapiens_hsa053321.84526538
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84096794
11Rheumatoid arthritis_Homo sapiens_hsa053231.79295630
12Lysosome_Homo sapiens_hsa041421.74624837
13Chemokine signaling pathway_Homo sapiens_hsa040621.64241686
14Phagosome_Homo sapiens_hsa041451.62341869
15Salmonella infection_Homo sapiens_hsa051321.58643425
16Synaptic vesicle cycle_Homo sapiens_hsa047211.58298603
17Nicotine addiction_Homo sapiens_hsa050331.57167452
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55166941
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.55049323
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52305816
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46202519
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45677603
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45056384
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.44546839
25Hematopoietic cell lineage_Homo sapiens_hsa046401.43830903
26African trypanosomiasis_Homo sapiens_hsa051431.42758283
27Legionellosis_Homo sapiens_hsa051341.40833010
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39784741
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36734140
30Allograft rejection_Homo sapiens_hsa053301.33902069
31Collecting duct acid secretion_Homo sapiens_hsa049661.33740893
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.33142130
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27449523
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27339854
35Primary immunodeficiency_Homo sapiens_hsa053401.24201957
36Morphine addiction_Homo sapiens_hsa050321.23165963
37Olfactory transduction_Homo sapiens_hsa047401.22743267
38Type I diabetes mellitus_Homo sapiens_hsa049401.20020739
39Malaria_Homo sapiens_hsa051441.18505896
40Other glycan degradation_Homo sapiens_hsa005111.16760076
41Circadian entrainment_Homo sapiens_hsa047131.15659656
42Glutamatergic synapse_Homo sapiens_hsa047241.15153475
43Asthma_Homo sapiens_hsa053101.14758737
44Measles_Homo sapiens_hsa051621.14235094
45Influenza A_Homo sapiens_hsa051641.14229537
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13413956
47TNF signaling pathway_Homo sapiens_hsa046681.08322101
48GABAergic synapse_Homo sapiens_hsa047271.04906212
49Renin secretion_Homo sapiens_hsa049241.04073236
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03867670
51Long-term potentiation_Homo sapiens_hsa047201.02866309
52Toxoplasmosis_Homo sapiens_hsa051450.98708992
53Prion diseases_Homo sapiens_hsa050200.97576917
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97358363
55Salivary secretion_Homo sapiens_hsa049700.93908561
56Serotonergic synapse_Homo sapiens_hsa047260.91999192
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87051365
58T cell receptor signaling pathway_Homo sapiens_hsa046600.86704077
59Cholinergic synapse_Homo sapiens_hsa047250.85816584
60Shigellosis_Homo sapiens_hsa051310.81694102
61Dopaminergic synapse_Homo sapiens_hsa047280.81676106
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80974439
63Platelet activation_Homo sapiens_hsa046110.78488345
64Amphetamine addiction_Homo sapiens_hsa050310.76927429
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.75907708
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.74802207
67Long-term depression_Homo sapiens_hsa047300.74381037
68Oxytocin signaling pathway_Homo sapiens_hsa049210.73756649
69MAPK signaling pathway_Homo sapiens_hsa040100.72486114
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72180410
71Autoimmune thyroid disease_Homo sapiens_hsa053200.70933926
72Calcium signaling pathway_Homo sapiens_hsa040200.70564155
73Acute myeloid leukemia_Homo sapiens_hsa052210.70146350
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.69523902
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68879780
76Hepatitis B_Homo sapiens_hsa051610.68588782
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67847605
78Ether lipid metabolism_Homo sapiens_hsa005650.66257432
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65839231
80Apoptosis_Homo sapiens_hsa042100.65588172
81GnRH signaling pathway_Homo sapiens_hsa049120.64320439
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62892938
83Type II diabetes mellitus_Homo sapiens_hsa049300.62762308
84Antigen processing and presentation_Homo sapiens_hsa046120.62516548
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61393083
86Prolactin signaling pathway_Homo sapiens_hsa049170.60100538
87cAMP signaling pathway_Homo sapiens_hsa040240.59637866
88Viral myocarditis_Homo sapiens_hsa054160.58833272
89Herpes simplex infection_Homo sapiens_hsa051680.57989615
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57826618
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57421740
92Cocaine addiction_Homo sapiens_hsa050300.57383709
93Vibrio cholerae infection_Homo sapiens_hsa051100.56432626
94Endocytosis_Homo sapiens_hsa041440.56311355
95Pancreatic cancer_Homo sapiens_hsa052120.56147166
96Hepatitis C_Homo sapiens_hsa051600.55810392
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.54255383
98Dorso-ventral axis formation_Homo sapiens_hsa043200.54207980
99Gastric acid secretion_Homo sapiens_hsa049710.53539065
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.53048322
101Systemic lupus erythematosus_Homo sapiens_hsa053220.51401945
102Axon guidance_Homo sapiens_hsa043600.49430857
103Epstein-Barr virus infection_Homo sapiens_hsa051690.47730937
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47188232
105ErbB signaling pathway_Homo sapiens_hsa040120.46687425
106Glioma_Homo sapiens_hsa052140.46418499
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46049949
108Renal cell carcinoma_Homo sapiens_hsa052110.44807426
109Non-small cell lung cancer_Homo sapiens_hsa052230.43157173
110VEGF signaling pathway_Homo sapiens_hsa043700.42866673
111Regulation of autophagy_Homo sapiens_hsa041400.41224162
112FoxO signaling pathway_Homo sapiens_hsa040680.39166622
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36758190
114Inositol phosphate metabolism_Homo sapiens_hsa005620.35902161
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33896045
116HIF-1 signaling pathway_Homo sapiens_hsa040660.33651739
117mTOR signaling pathway_Homo sapiens_hsa041500.32651242
118Amoebiasis_Homo sapiens_hsa051460.32333702
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.29611804
120Estrogen signaling pathway_Homo sapiens_hsa049150.29113188

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