MARCH10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.80792410
2spermatid development (GO:0007286)9.53574921
3motile cilium assembly (GO:0044458)9.46427483
4reproduction (GO:0000003)9.23043775
5piRNA metabolic process (GO:0034587)9.19555731
6male meiosis (GO:0007140)8.45032774
7regulation of cilium movement (GO:0003352)8.42256816
8cilium movement (GO:0003341)8.27524598
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.04893343
10synaptonemal complex organization (GO:0070193)7.95544160
11synaptonemal complex assembly (GO:0007130)7.62289890
12single fertilization (GO:0007338)7.50309113
13sperm capacitation (GO:0048240)6.91811775
14negative regulation of inclusion body assembly (GO:0090084)6.69151259
15fertilization (GO:0009566)6.47478921
16spermatogenesis (GO:0007283)6.36521856
17male gamete generation (GO:0048232)6.34238190
18left/right axis specification (GO:0070986)6.04814893
19DNA methylation involved in gamete generation (GO:0043046)5.87961580
20male meiosis I (GO:0007141)5.83876351
21gamete generation (GO:0007276)5.83530425
22microtubule depolymerization (GO:0007019)5.79522920
23organic cation transport (GO:0015695)5.78944278
24microtubule bundle formation (GO:0001578)5.74245318
25regulation of inclusion body assembly (GO:0090083)5.48328225
26germ cell development (GO:0007281)5.44010254
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.41775855
28ventricular system development (GO:0021591)5.36583444
29chromosome organization involved in meiosis (GO:0070192)5.30783738
30calcium ion-dependent exocytosis (GO:0017156)5.16456719
31phosphatidylethanolamine biosynthetic process (GO:0006646)5.06761023
32regulation of microtubule-based movement (GO:0060632)4.99084629
33meiotic nuclear division (GO:0007126)4.95631574
34cell recognition (GO:0008037)4.89823136
35seminiferous tubule development (GO:0072520)4.88813851
36meiosis I (GO:0007127)4.70899923
37microtubule severing (GO:0051013)4.63989775
38phosphatidylethanolamine metabolic process (GO:0046337)4.63875113
39multicellular organismal reproductive process (GO:0048609)4.59248973
40glomerular epithelial cell development (GO:0072310)4.39151684
41left/right pattern formation (GO:0060972)4.39068144
42primary alcohol catabolic process (GO:0034310)4.27798305
43regulation of interleukin-5 production (GO:0032674)4.27285054
44vitamin transmembrane transport (GO:0035461)4.23765625
45response to pheromone (GO:0019236)4.21953092
46regulation of interleukin-13 production (GO:0032656)4.19890061
47spermatid nucleus differentiation (GO:0007289)4.18902311
48glycerol ether metabolic process (GO:0006662)4.18549978
49one-carbon compound transport (GO:0019755)4.14934776
50meiotic cell cycle (GO:0051321)4.14492137
51chromosome condensation (GO:0030261)4.09580772
52ethanol metabolic process (GO:0006067)4.06106564
53establishment of apical/basal cell polarity (GO:0035089)4.04492117
54protein localization to cilium (GO:0061512)4.03650226
55DNA packaging (GO:0006323)3.95238036
56chaperone-mediated protein complex assembly (GO:0051131)3.88846255
57genitalia morphogenesis (GO:0035112)3.87364713
58ether metabolic process (GO:0018904)3.86595000
59monoubiquitinated protein deubiquitination (GO:0035520)3.86586487
60diterpenoid biosynthetic process (GO:0016102)3.75807404
61cell projection assembly (GO:0030031)3.74681767
62multicellular organismal development (GO:0007275)3.70578771
63protein polyglutamylation (GO:0018095)3.65710322
64protein targeting to Golgi (GO:0000042)3.49191287
65rRNA methylation (GO:0031167)3.48182328
66pyrimidine-containing compound transmembrane transport (GO:0072531)3.47738383
67establishment or maintenance of monopolar cell polarity (GO:0061339)3.41502333
68establishment of monopolar cell polarity (GO:0061162)3.41502333
69establishment of protein localization to Golgi (GO:0072600)3.39570696
70gene silencing by RNA (GO:0031047)3.38924003
71intraciliary transport (GO:0042073)3.37590739
72lateral ventricle development (GO:0021670)3.32562022
73cellular ketone body metabolic process (GO:0046950)3.31412159
74carnitine transport (GO:0015879)3.28934052
75amino-acid betaine transport (GO:0015838)3.28934052
76retrograde transport, vesicle recycling within Golgi (GO:0000301)3.25457661
77response to xenobiotic stimulus (GO:0009410)3.23251943
78lung epithelium development (GO:0060428)3.22966095
79axoneme assembly (GO:0035082)3.21088004
80protein refolding (GO:0042026)3.20873461
81meiotic cell cycle process (GO:1903046)3.20781090
82regulation of spindle checkpoint (GO:0090231)3.20011956
83carnitine transmembrane transport (GO:1902603)3.19409159
84synapsis (GO:0007129)3.18868687
85negative regulation of organelle assembly (GO:1902116)3.15943141
86negative regulation of T cell differentiation in thymus (GO:0033085)3.12861271
87lactate metabolic process (GO:0006089)3.11609645
88microtubule-based movement (GO:0007018)3.11241133
89ethanol oxidation (GO:0006069)3.11198453
90establishment of planar polarity (GO:0001736)3.06972441
91establishment of tissue polarity (GO:0007164)3.06972441
92single strand break repair (GO:0000012)3.03011358
93cilium organization (GO:0044782)3.00790055
94regulation of Rab GTPase activity (GO:0032313)2.99450467
95positive regulation of Rab GTPase activity (GO:0032851)2.99450467
96mitotic sister chromatid cohesion (GO:0007064)2.97963179
97microtubule polymerization or depolymerization (GO:0031109)2.97151048
98polyol catabolic process (GO:0046174)2.97114977
99negative regulation of humoral immune response (GO:0002921)2.95886177
100alditol metabolic process (GO:0019400)2.94697950
101glycolytic process (GO:0006096)2.94142712
102regulation of meiosis I (GO:0060631)2.93347817
103nucleoside diphosphate phosphorylation (GO:0006165)2.93327354
104negative regulation of B cell mediated immunity (GO:0002713)2.93209522
105negative regulation of immunoglobulin mediated immune response (GO:0002890)2.93209522
106cytoplasmic microtubule organization (GO:0031122)2.91770353
107nucleus organization (GO:0006997)2.91598202
108sequestering of actin monomers (GO:0042989)2.90001310
109protein K11-linked deubiquitination (GO:0035871)2.89417982
110ketone body metabolic process (GO:1902224)2.88938683
111cilium assembly (GO:0042384)2.85873828
112cilium morphogenesis (GO:0060271)2.85091911
113regulation of centriole replication (GO:0046599)2.84202559
114sexual reproduction (GO:0019953)2.81286308
115nuclear pore complex assembly (GO:0051292)2.81283666
116cellular component assembly involved in morphogenesis (GO:0010927)2.81192619
117tolerance induction (GO:0002507)2.78330121
118retinal rod cell development (GO:0046548)2.78269692
119rRNA modification (GO:0000154)2.77107274
120microtubule-based process (GO:0007017)2.76254522
121protein localization to Golgi apparatus (GO:0034067)2.75060700
122centriole assembly (GO:0098534)2.72820619
123phosphatidylcholine biosynthetic process (GO:0006656)2.67998191
124photoreceptor cell maintenance (GO:0045494)2.67918454
125GTP biosynthetic process (GO:0006183)2.63713213
126protein depolymerization (GO:0051261)2.63633512
127gene silencing (GO:0016458)2.61576120
128centriole replication (GO:0007099)2.60682683
129interferon-gamma secretion (GO:0072643)2.59113339
130peptidyl-glutamic acid modification (GO:0018200)2.58950406
131glycerol metabolic process (GO:0006071)2.51825973
132regulation of cilium assembly (GO:1902017)2.49024575
133fusion of sperm to egg plasma membrane (GO:0007342)13.7299240
134sperm motility (GO:0030317)12.9806632
135cilium or flagellum-dependent cell motility (GO:0001539)12.4544553
136acrosome assembly (GO:0001675)11.3576125
137sperm-egg recognition (GO:0035036)11.3242807
138acrosome reaction (GO:0007340)11.2984152
139cell wall macromolecule metabolic process (GO:0044036)11.2206092
140cell wall macromolecule catabolic process (GO:0016998)11.2206092
141multicellular organism reproduction (GO:0032504)11.0640305
142plasma membrane fusion (GO:0045026)10.4600446
143axonemal dynein complex assembly (GO:0070286)10.3867022
144binding of sperm to zona pellucida (GO:0007339)10.2992572
145cell-cell recognition (GO:0009988)10.1265650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.05785415
2EZH2_22144423_ChIP-Seq_EOC_Human5.01783857
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.30703707
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.31149403
5DROSHA_22980978_ChIP-Seq_HELA_Human2.93458567
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.70364756
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64102758
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63988130
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27542535
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22905366
11ZNF274_21170338_ChIP-Seq_K562_Hela2.16897609
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15432993
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14475245
14VDR_22108803_ChIP-Seq_LS180_Human2.11124129
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.07731862
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03660849
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.01090621
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6502826
19SMC4_20622854_ChIP-Seq_HELA_Human1.98823865
20ARNT_22903824_ChIP-Seq_MCF-7_Human1.93386968
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92452716
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90833265
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.85617269
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82938694
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76943201
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76166744
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.76160195
28TDRD3_21172665_ChIP-Seq_MCF-7_Human1.75555699
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69664903
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68438684
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.65795576
32CTCF_27219007_Chip-Seq_Bcells_Human1.64984226
33STAT1_17558387_ChIP-Seq_HELA_Human1.62904930
34AHR_22903824_ChIP-Seq_MCF-7_Human1.62604440
35TP63_22573176_ChIP-Seq_HFKS_Human1.61587276
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61029075
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.58335097
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57145795
39ETV1_20927104_ChIP-Seq_GIST48_Human1.56676643
40TP53_18474530_ChIP-ChIP_U2OS_Human1.54758237
41HNFA_21074721_ChIP-Seq_CACO-2_Human1.54428784
42CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.53399746
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.53290324
44ERA_21632823_ChIP-Seq_H3396_Human1.51821227
45GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51807807
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50575668
47RBPJ_21746931_ChIP-Seq_IB4_Human1.50526620
48MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49779514
49CTCF_20526341_ChIP-Seq_ESCs_Human1.47674607
50ER_23166858_ChIP-Seq_MCF-7_Human1.46641295
51SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45599685
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45014739
53P68_20966046_ChIP-Seq_HELA_Human1.44826549
54PHF8_20622853_ChIP-Seq_HELA_Human1.43720655
55CBX2_22325352_ChIP-Seq_293T-Rex_Human1.43694425
56CBP_20019798_ChIP-Seq_JUKART_Human1.43032583
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43032583
58PHF8_20622854_ChIP-Seq_HELA_Human1.41935209
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41438861
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.41196889
61KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40994964
62GATA3_21867929_ChIP-Seq_CD8_Mouse1.40602083
63TP63_23658742_ChIP-Seq_EP156T_Human1.40417003
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.39883529
65STAT1_20625510_ChIP-Seq_HELA_Human1.39707037
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39433087
67KDM2B_26808549_Chip-Seq_REH_Human1.38467678
68PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.38279253
69NANOG_20526341_ChIP-Seq_ESCs_Human1.38119226
70OCT4_20526341_ChIP-Seq_ESCs_Human1.34887895
71AR_21572438_ChIP-Seq_LNCaP_Human1.34599111
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.34078712
73SMRT_27268052_Chip-Seq_Bcells_Human1.34058277
74KLF5_25053715_ChIP-Seq_YYC3_Human1.33321992
75MYC_19829295_ChIP-Seq_ESCs_Human1.32870225
76E2F1_20622854_ChIP-Seq_HELA_Human1.31903342
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31708216
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.31560529
79TBL1_22424771_ChIP-Seq_293T_Human1.30030326
80P300_27268052_Chip-Seq_Bcells_Human1.29888305
81SMAD4_21799915_ChIP-Seq_A2780_Human1.29505785
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27871677
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27362606
84REST_21632747_ChIP-Seq_MESCs_Mouse1.25487076
85FUS_26573619_Chip-Seq_HEK293_Human1.25451067
86GATA6_21074721_ChIP-Seq_CACO-2_Human1.25438929
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.25056236
88FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24835833
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23396346
90CEBPB_22108803_ChIP-Seq_LS180_Human1.23001596
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.22643892
92BCOR_27268052_Chip-Seq_Bcells_Human1.22419171
93P53_21459846_ChIP-Seq_SAOS-2_Human1.22340725
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.21455225
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20956806
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20651386
97NFYA_21822215_ChIP-Seq_K562_Human1.19776654
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19479643
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19347044
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19262271
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19031201
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18537444
103GATA3_21867929_ChIP-Seq_TH1_Mouse1.18432833
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17917822
105GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17687619
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17504282
107BCL6_27268052_Chip-Seq_Bcells_Human1.17179729
108SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17097182
109AR_25329375_ChIP-Seq_VCAP_Human1.16011126
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15963559
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13744664
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.12665530
113GF1_26923725_Chip-Seq_HPCs_Mouse1.12480861
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11733322
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11733322
116P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.10706754
117RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10377316
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10367618
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.10365227
120STAT3_23295773_ChIP-Seq_U87_Human1.09833617
121CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09702717
122RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09428310
123TAF2_19829295_ChIP-Seq_ESCs_Human1.09196112
124RUNX2_22187159_ChIP-Seq_PCA_Human1.08691391
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.07476888
126SMAD4_21741376_ChIP-Seq_HESCs_Human1.07026745
127RAC3_21632823_ChIP-Seq_H3396_Human1.05663485
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04578262
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.04281195
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04277270
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04180566
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02943617
133SMAD3_21741376_ChIP-Seq_ESCs_Human1.02477347
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02177662
135TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02173540
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01899564
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00585441
138SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00139242
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00021694
140ERG_20517297_ChIP-Seq_VCAP_Human0.99987024
141SPI1_26923725_Chip-Seq_HPCs_Mouse0.99594178
142OCT4_18555785_Chip-Seq_ESCs_Mouse0.98534765
143FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98085772
144FOXA1_25329375_ChIP-Seq_VCAP_Human0.98085772
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98079584
146GATA3_21878914_ChIP-Seq_MCF-7_Human0.97892728
147CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97823911
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97055981
149RNF2_27304074_Chip-Seq_NSC_Mouse0.96094852
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.96005651
151LXR_22292898_ChIP-Seq_THP-1_Human0.95865543
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95604524
153TAF15_26573619_Chip-Seq_HEK293_Human0.95318770
154SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95186968
155KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94504113
156P53_22387025_ChIP-Seq_ESCs_Mouse0.94343460
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94238653
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.93981154
159MYC_27129775_Chip-Seq_CORNEA_Mouse0.93805733
160EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93544378
161RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93275299
162TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93113022
163OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92184082
164RARA_24833708_ChIP-Seq_LIVER_Mouse0.91417211
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91255256
166EZH2_27294783_Chip-Seq_NPCs_Mouse0.91028615
167KLF4_18555785_Chip-Seq_ESCs_Mouse0.89426099
168P300_18555785_Chip-Seq_ESCs_Mouse0.89105744
169CMYC_18555785_Chip-Seq_ESCs_Mouse0.87672804
170LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87605737
171PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87226926
172SOX2_21211035_ChIP-Seq_LN229_Human0.87156776
173PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86594892
174FLI1_21867929_ChIP-Seq_CD8_Mouse0.86324975
175ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86260159
176ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85910477
177SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85569599
178NFYB_21822215_ChIP-Seq_K562_Human0.85475948
179GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85171941
180SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84792308
181EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83906758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.06493045
2MP0001929_abnormal_gametogenesis5.58255025
3MP0008877_abnormal_DNA_methylation4.97306028
4MP0002132_abnormal_respiratory_system4.74143736
5MP0008875_abnormal_xenobiotic_pharmacok4.03319342
6MP0002210_abnormal_sex_determination3.69154321
7MP0002161_abnormal_fertility/fecundity3.30524726
8MP0001145_abnormal_male_reproductive3.10958740
9MP0002653_abnormal_ependyma_morphology2.92745900
10MP0000653_abnormal_sex_gland2.70590532
11MP0000678_abnormal_parathyroid_gland2.46640132
12MP0008789_abnormal_olfactory_epithelium2.39656305
13MP0005670_abnormal_white_adipose2.34568229
14MP0004043_abnormal_pH_regulation2.23098067
15MP0009780_abnormal_chondrocyte_physiolo2.17253851
16MP0005410_abnormal_fertilization15.8289320
17MP0002160_abnormal_reproductive_system1.94746614
18MP0003718_maternal_effect1.89267060
19MP0001348_abnormal_lacrimal_gland1.83545703
20MP0005623_abnormal_meninges_morphology1.82638818
21MP0002249_abnormal_larynx_morphology1.82525431
22MP0002277_abnormal_respiratory_mucosa1.72525856
23MP0000566_synostosis1.71626132
24MP0001485_abnormal_pinna_reflex1.66833260
25MP0003646_muscle_fatigue1.63014808
26MP0005395_other_phenotype1.58907203
27MP0005499_abnormal_olfactory_system1.58315823
28MP0005394_taste/olfaction_phenotype1.58315823
29MP0005083_abnormal_biliary_tract1.55104749
30MP0005248_abnormal_Harderian_gland1.39267938
31MP0002168_other_aberrant_phenotype1.38784277
32MP0000383_abnormal_hair_follicle1.37341602
33MP0004233_abnormal_muscle_weight1.35291014
34MP0002282_abnormal_trachea_morphology1.32016007
35MP0002822_catalepsy1.32003053
36MP0002735_abnormal_chemical_nociception1.27249772
37MP0005310_abnormal_salivary_gland1.19709827
38MP0010678_abnormal_skin_adnexa1.10746486
39MP0001984_abnormal_olfaction1.07685733
40MP0001765_abnormal_ion_homeostasis1.06243343
41MP0005647_abnormal_sex_gland1.06056394
42MP0008995_early_reproductive_senescence1.05848143
43MP0001963_abnormal_hearing_physiology1.04170797
44MP0008058_abnormal_DNA_repair1.03779663
45MP0002734_abnormal_mechanical_nocicepti1.03723664
46MP0000026_abnormal_inner_ear1.02682041
47MP0009046_muscle_twitch1.00684702
48MP0005389_reproductive_system_phenotype0.98740308
49MP0008057_abnormal_DNA_replication0.95733699
50MP0000681_abnormal_thyroid_gland0.94457917
51MP0001486_abnormal_startle_reflex0.89678100
52MP0009053_abnormal_anal_canal0.85064515
53MP0010094_abnormal_chromosome_stability0.84743377
54MP0003011_delayed_dark_adaptation0.76341025
55MP0003136_yellow_coat_color0.75967435
56MP0001346_abnormal_lacrimal_gland0.75947313
57MP0003878_abnormal_ear_physiology0.73936583
58MP0005377_hearing/vestibular/ear_phenot0.73936583
59MP0000049_abnormal_middle_ear0.72742488
60MP0003115_abnormal_respiratory_system0.70428721
61MP0000955_abnormal_spinal_cord0.69772133
62MP0000569_abnormal_digit_pigmentation0.69236108
63MP0002234_abnormal_pharynx_morphology0.69137770
64MP0008004_abnormal_stomach_pH0.68829272
65MP0002909_abnormal_adrenal_gland0.65802742
66MP0003786_premature_aging0.64252607
67MP0010030_abnormal_orbit_morphology0.63307637
68MP0005379_endocrine/exocrine_gland_phen0.62952640
69MP0001968_abnormal_touch/_nociception0.61428730
70MP0001270_distended_abdomen0.61376572
71MP0001905_abnormal_dopamine_level0.61148927
72MP0005408_hypopigmentation0.58913521
73MP0000358_abnormal_cell_content/0.58577905
74MP0002557_abnormal_social/conspecific_i0.58141105
75MP0002233_abnormal_nose_morphology0.56283408
76MP0002136_abnormal_kidney_physiology0.56104789
77MP0001970_abnormal_pain_threshold0.55754735
78MP0001879_abnormal_lymphatic_vessel0.55221319
79MP0008007_abnormal_cellular_replicative0.54362682
80MP0009643_abnormal_urine_homeostasis0.53991924
81MP0003699_abnormal_female_reproductive0.53829881
82MP0005636_abnormal_mineral_homeostasis0.53825535
83MP0004085_abnormal_heartbeat0.53783149
84MP0005423_abnormal_somatic_nervous0.52413292
85MP0003950_abnormal_plasma_membrane0.52283754
86MP0003656_abnormal_erythrocyte_physiolo0.52147577
87MP0001666_abnormal_nutrient_absorption0.51486954
88MP0001545_abnormal_hematopoietic_system0.50644074
89MP0005397_hematopoietic_system_phenotyp0.50644074
90MP0003329_amyloid_beta_deposits0.50369130
91MP0005666_abnormal_adipose_tissue0.50228239
92MP0009278_abnormal_bone_marrow0.49375390
93MP0002928_abnormal_bile_duct0.48215828
94MP0003111_abnormal_nucleus_morphology0.46441173
95MP0002876_abnormal_thyroid_physiology0.46247086
96MP0001293_anophthalmia0.46211590
97MP0001324_abnormal_eye_pigmentation0.45202202
98MP0004859_abnormal_synaptic_plasticity0.44705189
99MP0009765_abnormal_xenobiotic_induced0.44355022
100MP0001299_abnormal_eye_distance/0.44075606
101MP0004036_abnormal_muscle_relaxation0.44008013
102MP0005164_abnormal_response_to0.43706307
103MP0005365_abnormal_bile_salt0.43640169
104MP0001502_abnormal_circadian_rhythm0.42951524
105MP0005195_abnormal_posterior_eye0.42772443
106MP0002269_muscular_atrophy0.41493180
107MP0002067_abnormal_sensory_capabilities0.41435133
108MP0002572_abnormal_emotion/affect_behav0.41255229
109MP0010368_abnormal_lymphatic_system0.40900527
110MP0001119_abnormal_female_reproductive0.39852874
111MP0002102_abnormal_ear_morphology0.38469476
112MP0005551_abnormal_eye_electrophysiolog0.37323491
113MP0005253_abnormal_eye_physiology0.37031978
114MP0001764_abnormal_homeostasis0.35529816
115MP0001730_embryonic_growth_arrest0.34880627
116MP0006036_abnormal_mitochondrial_physio0.34287240
117MP0004808_abnormal_hematopoietic_stem0.32892664
118MP0009115_abnormal_fat_cell0.32880058
119MP0005391_vision/eye_phenotype0.31958172
120MP0010307_abnormal_tumor_latency0.31871704
121MP0000534_abnormal_ureter_morphology0.31345832
122MP0002971_abnormal_brown_adipose0.30923776
123MP0003879_abnormal_hair_cell0.30365817
124MP0001727_abnormal_embryo_implantation0.30345068
125MP0004134_abnormal_chest_morphology0.29351019
126MP0004811_abnormal_neuron_physiology0.28368134
127MP0003861_abnormal_nervous_system0.28165090
128MP0003942_abnormal_urinary_system0.26525184
129MP0004019_abnormal_vitamin_homeostasis0.26132772
130MP0008961_abnormal_basal_metabolism0.26065884
131MP0002152_abnormal_brain_morphology0.25512304
132MP0001661_extended_life_span0.25163808
133MP0003633_abnormal_nervous_system0.24447391
134MP0000751_myopathy0.24303386
135MP0000604_amyloidosis0.22044229
136MP0002736_abnormal_nociception_after0.22016720
137MP0000313_abnormal_cell_death0.21952735
138MP0003045_fibrosis0.21400234
139MP0004133_heterotaxia0.21266130
140MP0002084_abnormal_developmental_patter0.20339122
141MP0002092_abnormal_eye_morphology0.20277454
142MP0006035_abnormal_mitochondrial_morpho0.19945216
143MP0003631_nervous_system_phenotype0.19577226
144MP0003077_abnormal_cell_cycle0.18286514
145MP0003948_abnormal_gas_homeostasis0.17971881
146MP0002295_abnormal_pulmonary_circulatio0.17222347
147MP0002169_no_abnormal_phenotype0.17012758
148MP0002873_normal_phenotype0.16760063
149MP0003787_abnormal_imprinting0.15470974
150MP0004742_abnormal_vestibular_system0.15222064
151MP0001697_abnormal_embryo_size0.14771825
152MP0002229_neurodegeneration0.14594549
153MP0001672_abnormal_embryogenesis/_devel0.14441231
154MP0005380_embryogenesis_phenotype0.14441231
155MP0002108_abnormal_muscle_morphology0.13825367
156MP0004270_analgesia0.13816583
157MP0005375_adipose_tissue_phenotype0.13429794
158MP0001851_eye_inflammation0.13229982
159MP0003936_abnormal_reproductive_system0.12848814
160MP0000001_mammalian_phenotype0.12393690
161MP0001849_ear_inflammation0.12306889
162MP0002139_abnormal_hepatobiliary_system0.12296261

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.32347276
2Abnormal respiratory epithelium morphology (HP:0012253)9.06134768
3Abnormal respiratory motile cilium morphology (HP:0005938)9.06134768
4Rhinitis (HP:0012384)7.81578788
5Abnormal ciliary motility (HP:0012262)7.44514295
6Chronic bronchitis (HP:0004469)7.22898827
7Infertility (HP:0000789)6.69885887
8Nasal polyposis (HP:0100582)6.38826818
9Abnormality of the nasal mucosa (HP:0000433)5.24527531
10Bronchiectasis (HP:0002110)4.55477280
11Bronchitis (HP:0012387)4.53544159
12Nephronophthisis (HP:0000090)4.51025796
13Male infertility (HP:0003251)4.22961109
14Occipital encephalocele (HP:0002085)3.50619730
15Chronic hepatic failure (HP:0100626)3.45967119
16Abnormality of the renal medulla (HP:0100957)3.42436343
17Abnormal spermatogenesis (HP:0008669)3.39607805
18Recurrent sinusitis (HP:0011108)3.31870384
19Recurrent otitis media (HP:0000403)3.29144485
20Tubulointerstitial nephritis (HP:0001970)2.98348013
21Gonadotropin excess (HP:0000837)2.86695367
22True hermaphroditism (HP:0010459)2.86484978
23Atelectasis (HP:0100750)2.83617317
24Abnormality of the lower motor neuron (HP:0002366)2.76245570
25Recurrent bronchitis (HP:0002837)2.73974380
26Tubular atrophy (HP:0000092)2.70512297
27Abnormality of midbrain morphology (HP:0002418)2.66341490
28Molar tooth sign on MRI (HP:0002419)2.66341490
29Impulsivity (HP:0100710)2.58904689
30Medial flaring of the eyebrow (HP:0010747)2.58341753
31Tubulointerstitial abnormality (HP:0001969)2.54707132
32Pancreatic cysts (HP:0001737)2.50177664
33Hyperkalemia (HP:0002153)2.49668883
34Hyperactive renin-angiotensin system (HP:0000841)2.44930377
35Azoospermia (HP:0000027)2.39954685
36Amyotrophic lateral sclerosis (HP:0007354)2.18670473
37Severe visual impairment (HP:0001141)2.18102501
38Chronic otitis media (HP:0000389)2.10902855
39Fibular hypoplasia (HP:0003038)2.06702425
40Bony spicule pigmentary retinopathy (HP:0007737)2.04756601
41Tubulointerstitial fibrosis (HP:0005576)2.04707285
42Cone-rod dystrophy (HP:0000548)2.04613843
43Abnormal gallbladder physiology (HP:0012438)2.03798382
44Cholecystitis (HP:0001082)2.03798382
45Postaxial foot polydactyly (HP:0001830)2.00405725
46Abnormal rod and cone electroretinograms (HP:0008323)2.00070660
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2473272
48Absent/shortened dynein arms (HP:0200106)13.0805327
49Dynein arm defect of respiratory motile cilia (HP:0012255)13.0805327
50Stage 5 chronic kidney disease (HP:0003774)1.97192465
51Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94463064
52Polydipsia (HP:0001959)1.87505587
53Abnormal drinking behavior (HP:0030082)1.87505587
54Anencephaly (HP:0002323)1.87041749
55Spastic tetraparesis (HP:0001285)1.85346842
56Abnormality of macular pigmentation (HP:0008002)1.84433972
57Congenital hepatic fibrosis (HP:0002612)1.83379814
58Male pseudohermaphroditism (HP:0000037)1.82364801
59Abnormality of the renal cortex (HP:0011035)1.79462071
60Short ribs (HP:0000773)1.78102272
61Impaired proprioception (HP:0010831)1.76807126
62Heterotopia (HP:0002282)1.75300232
63Oculomotor apraxia (HP:0000657)1.72405826
64Dyschromatopsia (HP:0007641)1.72140072
65Abnormality of dentin (HP:0010299)1.66349995
66Sclerocornea (HP:0000647)1.66280175
67Absent frontal sinuses (HP:0002688)1.64718357
68Renal dysplasia (HP:0000110)1.63437651
69Abnormality of renal excretion (HP:0011036)1.63162744
70Abnormality of the dental root (HP:0006486)1.63060210
71Taurodontia (HP:0000679)1.63060210
72Abnormality of permanent molar morphology (HP:0011071)1.63060210
73Renal salt wasting (HP:0000127)1.61639731
74J-shaped sella turcica (HP:0002680)1.57174351
75Microglossia (HP:0000171)1.56657370
76Bell-shaped thorax (HP:0001591)1.56452648
77Postaxial hand polydactyly (HP:0001162)1.56355867
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.56116048
79Chronic sinusitis (HP:0011109)1.53142244
80Bile duct proliferation (HP:0001408)1.53047674
81Abnormal biliary tract physiology (HP:0012439)1.53047674
82Absent epiphyses (HP:0010577)1.52962668
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52962668
84Choroideremia (HP:0001139)1.51495034
85Facial cleft (HP:0002006)1.51491818
86Abnormality of molar morphology (HP:0011070)1.51461026
87Abnormality of molar (HP:0011077)1.51461026
88Abnormality of the dental pulp (HP:0006479)1.48578725
89Decreased circulating renin level (HP:0003351)1.48477710
90Abnormality of chloride homeostasis (HP:0011422)1.48234953
91Upper motor neuron abnormality (HP:0002127)1.48042431
92Decreased central vision (HP:0007663)1.46472330
93Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.45356914
94Supernumerary spleens (HP:0009799)1.44726908
95Deformed sella turcica (HP:0002681)1.44525643
96Hyponatremia (HP:0002902)1.43362821
97Congenital primary aphakia (HP:0007707)1.40827681
98Gait imbalance (HP:0002141)1.40328598
99Poor coordination (HP:0002370)1.39916067
100Hyperaldosteronism (HP:0000859)1.38404961
101Cystic liver disease (HP:0006706)1.37899263
102Aplasia/Hypoplasia of the lens (HP:0008063)1.37811299
103Short thorax (HP:0010306)1.36232993
104Short nail (HP:0001799)1.34902020
105Attenuation of retinal blood vessels (HP:0007843)1.34878648
106Abnormal urine output (HP:0012590)1.33273632
107Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.32565738
108Broad distal phalanx of finger (HP:0009836)1.32102375
109Degeneration of anterior horn cells (HP:0002398)1.30954173
110Abnormality of the anterior horn cell (HP:0006802)1.30954173
111Resting tremor (HP:0002322)1.30736417
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.29077988
113Genital tract atresia (HP:0001827)1.28991162
114Hemorrhage of the eye (HP:0011885)1.28571402
115Abnormality of ocular smooth pursuit (HP:0000617)1.28555889
116Nephropathy (HP:0000112)1.27763898
117Vaginal atresia (HP:0000148)1.27228853
118Median cleft lip (HP:0000161)1.26547393
119Aplasia/Hypoplasia of the fibula (HP:0006492)1.26179613
120Cerebellar dysplasia (HP:0007033)1.25460200
121Neurofibrillary tangles (HP:0002185)1.24897988
122Progressive sensorineural hearing impairment (HP:0000408)1.24661422
123Pancreatic fibrosis (HP:0100732)1.24636499
124Hand muscle atrophy (HP:0009130)1.21858252
125Portal hypertension (HP:0001409)1.21062314
126Fetal akinesia sequence (HP:0001989)1.20783411
127Short femoral neck (HP:0100864)1.19851379
128Asplenia (HP:0001746)1.19626258
129Preaxial hand polydactyly (HP:0001177)1.19600727
130Pachygyria (HP:0001302)1.19319447
131Nephrogenic diabetes insipidus (HP:0009806)1.19009812
132Hemiparesis (HP:0001269)1.18866464
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.18295902
134Furrowed tongue (HP:0000221)1.18228621
135Hypokalemic alkalosis (HP:0001949)1.18217460
136Asymmetric septal hypertrophy (HP:0001670)1.17669469
137Polyuria (HP:0000103)1.17141053
138Glucose intolerance (HP:0000833)1.14643591
139Abnormality of saccadic eye movements (HP:0000570)1.14478370
140Abnormality of renin-angiotensin system (HP:0000847)1.12547337
141Menstrual irregularities (HP:0000858)1.11849879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.57198398
2PDK48.57198398
3TESK15.57145496
4PDK25.54757790
5PRKD34.65528438
6ICK4.03352945
7MST43.56387901
8EPHA23.09900191
9PTK2B2.47199198
10PNCK2.39013540
11MST1R2.36112834
12DDR22.35642740
13WNK42.32152099
14INSRR2.24496149
15STK392.18834383
16NEK21.78059848
17MAP3K21.76456931
18NME11.63712736
19STK381.63393376
20MAP4K21.55900604
21BRD41.44958934
22PLK21.40960252
23MAPKAPK31.29071289
24DYRK1B1.25705080
25TLK11.25664062
26STK161.19805620
27PDK11.01427000
28TYRO31.01256795
29WNK11.00496879
30MAPK151.00177723
31STK240.94025386
32FRK0.84021510
33MET0.83037738
34STK30.78967629
35CCNB10.77521990
36DYRK30.75516641
37MAP3K30.75244512
38PASK0.74513868
39CSK0.72407047
40TRPM70.71953349
41SMG10.71544361
42LATS10.70622798
43TTK0.67066825
44CAMK1G0.64755625
45IRAK10.62923382
46ROCK10.62219449
47RPS6KA20.60601434
48CDC70.59950830
49MAP3K70.58950827
50PRKAA20.58671216
51EEF2K0.56964387
52CHEK20.55863981
53PINK10.54960717
54BCR0.54034698
55AURKA0.52363470
56MAP2K20.52083960
57TESK20.51854113
58PDPK10.50140146
59OXSR10.49326626
60CHEK10.47000342
61LMTK20.46960225
62MYLK0.45600453
63WEE10.44189687
64SGK10.43135997
65PLK40.42826879
66MAP2K60.40953476
67CDK70.40132857
68PIK3CG0.39853237
69ATR0.38469188
70UHMK10.38027195
71FER0.37132408
72PRKCI0.36597401
73STK38L0.35577860
74RIPK40.34941492
75PAK10.34876583
76NTRK20.33804972
77ATM0.33226033
78KSR20.32272530
79MTOR0.31384497
80LATS20.30645170
81LRRK20.30522963
82MAP3K80.30312837
83CDK120.28612202
84MUSK0.28581986
85PAK20.28307694
86ERBB30.27490698
87PRKCG0.27178033
88ERBB20.26370880
89CDK190.26082158
90IRAK20.25963566
91MAP3K110.24103012
92SGK4940.23251344
93SGK2230.23251344
94PRKACA0.22708964
95PRKAA10.22338773
96CAMK10.22179015
97CAMKK10.21239345
98MARK20.21203135
99ARAF0.21102399
100CAMK2G0.20913537
101PLK10.19338192
102NEK60.18941935
103MAPKAPK50.17867560
104RPS6KB10.17813589
105MAPK10.16573409
106ROCK20.16163856
107MAPK110.15002937
108MAP2K70.14716152
109PRKCD0.14438454
110PAK40.13853721
111AKT20.13017926
112MAP3K100.12890220
113WNK30.09930776
114BRAF0.09473643
115PRKCZ0.09312478
116BRSK20.09184626
117MAP3K40.08168060
118BMPR1B0.07822776
119CDK150.07814348
120PRKCQ0.07035454
121CSNK1D0.06657983
122GSK3B0.05719912
123CDK180.05627934
124CSNK2A10.05249267
125PAK60.05077624
126CDK10.04749203
127CDK20.04713972
128CDK11A0.04466576
129RPS6KA10.04317793
130STK110.03876160
131PRKG10.03335328
132MARK30.02664912
133MAPK80.02334763
134BRSK10.02311224
135CSF1R0.01781080
136PRKACG0.01779555
137CDK140.01607059
138STK100.00817527
139PRKDC0.00628828
140CSNK2A20.00206286
141ZAP70-0.0305460
142MAP3K5-0.0301247
143PKN1-0.0293301
144PRKCA-0.0289767
145RPS6KA3-0.0210372
146RIPK1-0.0202284
147PRKG2-0.0179933
148PDGFRB-0.0162876
149CDK4-0.0156227
150CDK3-0.0129490
151CDK6-0.0093660
152TAOK1-0.0090887
153EGFR-0.0044061
154PRKACB-0.0023582
155CAMK2A-0.0017781
156PRKCB-0.0013224

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.41916869
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.39839543
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.35120833
4Vitamin B6 metabolism_Homo sapiens_hsa007504.28567145
5Pyruvate metabolism_Homo sapiens_hsa006204.01068198
6Fatty acid biosynthesis_Homo sapiens_hsa000613.90585587
7Histidine metabolism_Homo sapiens_hsa003403.61165866
8Tyrosine metabolism_Homo sapiens_hsa003503.15209779
9Propanoate metabolism_Homo sapiens_hsa006403.10977827
10Glucagon signaling pathway_Homo sapiens_hsa049222.81575213
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75277169
12Linoleic acid metabolism_Homo sapiens_hsa005912.63862874
13beta-Alanine metabolism_Homo sapiens_hsa004102.61115955
14Basal transcription factors_Homo sapiens_hsa030222.54638188
15Olfactory transduction_Homo sapiens_hsa047402.45888538
16Selenocompound metabolism_Homo sapiens_hsa004502.39637369
17Dorso-ventral axis formation_Homo sapiens_hsa043202.27639816
18Retinol metabolism_Homo sapiens_hsa008302.10035133
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09965159
20Carbohydrate digestion and absorption_Homo sapiens_hsa049732.04445164
21Pentose phosphate pathway_Homo sapiens_hsa000302.00399611
22Glycerolipid metabolism_Homo sapiens_hsa005611.99962075
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.93949075
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92662821
25Fanconi anemia pathway_Homo sapiens_hsa034601.92213012
26Oocyte meiosis_Homo sapiens_hsa041141.91884568
27PPAR signaling pathway_Homo sapiens_hsa033201.74471674
28Butanoate metabolism_Homo sapiens_hsa006501.73956705
29Amphetamine addiction_Homo sapiens_hsa050311.60840088
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.53212555
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.50763484
32Caffeine metabolism_Homo sapiens_hsa002321.50128716
33Fructose and mannose metabolism_Homo sapiens_hsa000511.49989636
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.48404961
35Huntingtons disease_Homo sapiens_hsa050161.47340496
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.43697038
37Carbon metabolism_Homo sapiens_hsa012001.36137633
38Tight junction_Homo sapiens_hsa045301.34165251
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31080835
40mRNA surveillance pathway_Homo sapiens_hsa030151.30891282
41Cardiac muscle contraction_Homo sapiens_hsa042601.29140985
42Renin secretion_Homo sapiens_hsa049241.25803843
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21233588
44Ether lipid metabolism_Homo sapiens_hsa005651.21225126
45Fat digestion and absorption_Homo sapiens_hsa049751.20152649
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.19991488
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19293843
48Fatty acid metabolism_Homo sapiens_hsa012121.18259781
49Mineral absorption_Homo sapiens_hsa049781.16966943
50Antigen processing and presentation_Homo sapiens_hsa046121.16494908
51RNA transport_Homo sapiens_hsa030131.14096330
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11940707
53Fatty acid degradation_Homo sapiens_hsa000711.10750468
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10296389
55Sphingolipid metabolism_Homo sapiens_hsa006001.06608571
56Circadian rhythm_Homo sapiens_hsa047101.00912189
57Purine metabolism_Homo sapiens_hsa002300.95542097
58Peroxisome_Homo sapiens_hsa041460.90088513
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88217514
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87856643
61Long-term potentiation_Homo sapiens_hsa047200.86261203
62Biosynthesis of amino acids_Homo sapiens_hsa012300.83680658
63Arginine and proline metabolism_Homo sapiens_hsa003300.80410646
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78985631
65Phototransduction_Homo sapiens_hsa047440.78703479
66Estrogen signaling pathway_Homo sapiens_hsa049150.77556811
67Glutathione metabolism_Homo sapiens_hsa004800.76346244
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73168026
69Hedgehog signaling pathway_Homo sapiens_hsa043400.69067003
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.69034997
71Collecting duct acid secretion_Homo sapiens_hsa049660.68989807
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.67336336
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67140572
74ABC transporters_Homo sapiens_hsa020100.66817312
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.66577137
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66090628
77Nicotine addiction_Homo sapiens_hsa050330.64012927
78Insulin secretion_Homo sapiens_hsa049110.63575891
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62634393
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62604551
81Arachidonic acid metabolism_Homo sapiens_hsa005900.61093583
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60884379
83Chemical carcinogenesis_Homo sapiens_hsa052040.59988720
84Type I diabetes mellitus_Homo sapiens_hsa049400.58402474
85Calcium signaling pathway_Homo sapiens_hsa040200.57151946
86Thyroid hormone synthesis_Homo sapiens_hsa049180.55781701
87Type II diabetes mellitus_Homo sapiens_hsa049300.55691650
88Legionellosis_Homo sapiens_hsa051340.55047905
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53473979
90Bile secretion_Homo sapiens_hsa049760.52550712
91Choline metabolism in cancer_Homo sapiens_hsa052310.52432856
92Adherens junction_Homo sapiens_hsa045200.51287102
93Arginine biosynthesis_Homo sapiens_hsa002200.49553944
94AMPK signaling pathway_Homo sapiens_hsa041520.48168318
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48144415
96Starch and sucrose metabolism_Homo sapiens_hsa005000.48017727
97VEGF signaling pathway_Homo sapiens_hsa043700.47459470
98Renin-angiotensin system_Homo sapiens_hsa046140.46803365
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46706777
100Endocytosis_Homo sapiens_hsa041440.45574116
101Nitrogen metabolism_Homo sapiens_hsa009100.44679776
102Inositol phosphate metabolism_Homo sapiens_hsa005620.43158151
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42400927
104Systemic lupus erythematosus_Homo sapiens_hsa053220.41761917
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41588067
106Synaptic vesicle cycle_Homo sapiens_hsa047210.41063228
107N-Glycan biosynthesis_Homo sapiens_hsa005100.40463441
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38665203
109Protein digestion and absorption_Homo sapiens_hsa049740.36714603
110Serotonergic synapse_Homo sapiens_hsa047260.35969066
111Notch signaling pathway_Homo sapiens_hsa043300.35817382
112Taste transduction_Homo sapiens_hsa047420.35812067
113Salivary secretion_Homo sapiens_hsa049700.34787700
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34502906
115Pancreatic secretion_Homo sapiens_hsa049720.34301138
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33959368
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.33856203
118Autoimmune thyroid disease_Homo sapiens_hsa053200.33186651
119Metabolic pathways_Homo sapiens_hsa011000.32886584
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32830470
121Graft-versus-host disease_Homo sapiens_hsa053320.32276690
122Gastric acid secretion_Homo sapiens_hsa049710.31449183
123Allograft rejection_Homo sapiens_hsa053300.30745783
124Circadian entrainment_Homo sapiens_hsa047130.30266918
125Tryptophan metabolism_Homo sapiens_hsa003800.30061690
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29266451
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.29143019
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29040076
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28512093
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27819430
131cAMP signaling pathway_Homo sapiens_hsa040240.27608857
132Basal cell carcinoma_Homo sapiens_hsa052170.27595588
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.23187431
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22959555
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21674854
136Gap junction_Homo sapiens_hsa045400.21508830
137RNA degradation_Homo sapiens_hsa030180.21163010
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20985092
139Pyrimidine metabolism_Homo sapiens_hsa002400.20577291
140Alcoholism_Homo sapiens_hsa050340.20223929
141ECM-receptor interaction_Homo sapiens_hsa045120.16606308
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16523062
143Wnt signaling pathway_Homo sapiens_hsa043100.16323630
144Cocaine addiction_Homo sapiens_hsa050300.15470497
145B cell receptor signaling pathway_Homo sapiens_hsa046620.15391547
146Cell cycle_Homo sapiens_hsa041100.11133715
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10822211
148Viral carcinogenesis_Homo sapiens_hsa052030.10444356
149Glutamatergic synapse_Homo sapiens_hsa047240.10041977
150HIF-1 signaling pathway_Homo sapiens_hsa040660.08594432

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