MARCH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)6.22214557
2neutrophil activation involved in immune response (GO:0002283)5.76670345
3protoporphyrinogen IX biosynthetic process (GO:0006782)5.49538503
4fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.68110612
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.66820995
6L-phenylalanine catabolic process (GO:0006559)4.66820995
7alpha-linolenic acid metabolic process (GO:0036109)4.65460297
8porphyrin-containing compound biosynthetic process (GO:0006779)4.61494869
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.46300281
10L-phenylalanine metabolic process (GO:0006558)4.46300281
11heme biosynthetic process (GO:0006783)4.36243032
12regulation of platelet aggregation (GO:0090330)4.25584150
13lysine catabolic process (GO:0006554)4.24252287
14lysine metabolic process (GO:0006553)4.24252287
15tetrapyrrole biosynthetic process (GO:0033014)4.14675709
16porphyrin-containing compound metabolic process (GO:0006778)4.08407958
17response to methylmercury (GO:0051597)3.97671745
18cysteine metabolic process (GO:0006534)3.94953107
19fatty acid beta-oxidation (GO:0006635)3.94765923
20heme metabolic process (GO:0042168)3.94708211
21positive regulation of mast cell activation (GO:0033005)3.93576043
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.92496650
23aromatic amino acid family catabolic process (GO:0009074)3.90177791
24neutrophil activation (GO:0042119)3.81667889
25fatty acid transmembrane transport (GO:1902001)3.81328913
26leukocyte migration involved in inflammatory response (GO:0002523)3.80802690
27regulation of platelet activation (GO:0010543)3.79209935
28thrombin receptor signaling pathway (GO:0070493)3.76148529
29regulation of triglyceride catabolic process (GO:0010896)3.75040552
30granulocyte activation (GO:0036230)3.65586709
31fatty acid oxidation (GO:0019395)3.62854778
32carnitine shuttle (GO:0006853)3.62766884
33glyoxylate metabolic process (GO:0046487)3.60546182
34fatty acid catabolic process (GO:0009062)3.59381675
35adenosine receptor signaling pathway (GO:0001973)3.58890254
36lipid oxidation (GO:0034440)3.58388170
37aspartate family amino acid catabolic process (GO:0009068)3.55811975
38bile acid biosynthetic process (GO:0006699)3.55522452
39kynurenine metabolic process (GO:0070189)3.53306074
40acetyl-CoA metabolic process (GO:0006084)3.50153020
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49687400
422-oxoglutarate metabolic process (GO:0006103)3.49446975
43complement activation, alternative pathway (GO:0006957)3.47061030
44regulation of sequestering of triglyceride (GO:0010889)3.42822026
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41717276
46negative regulation of cell killing (GO:0031342)3.41717276
47very-low-density lipoprotein particle assembly (GO:0034379)3.41689906
48valine metabolic process (GO:0006573)3.39621325
49amino-acid betaine metabolic process (GO:0006577)3.38668359
50short-chain fatty acid metabolic process (GO:0046459)3.38288309
51monocarboxylic acid catabolic process (GO:0072329)3.33992684
52indole-containing compound catabolic process (GO:0042436)3.27756197
53indolalkylamine catabolic process (GO:0046218)3.27756197
54tryptophan catabolic process (GO:0006569)3.27756197
55hemoglobin metabolic process (GO:0020027)3.26811052
56sulfur amino acid catabolic process (GO:0000098)3.25832904
57plasma lipoprotein particle clearance (GO:0034381)3.24878503
58cellular ketone body metabolic process (GO:0046950)3.24280940
59carnitine transmembrane transport (GO:1902603)3.23916838
60plasma lipoprotein particle assembly (GO:0034377)3.23597978
61regulation of protein activation cascade (GO:2000257)3.23293563
62positive regulation of gamma-delta T cell activation (GO:0046645)3.20960435
63carnitine metabolic process (GO:0009437)3.18765386
64amino-acid betaine transport (GO:0015838)3.17172819
65carnitine transport (GO:0015879)3.17172819
66regulation of mast cell degranulation (GO:0043304)3.15484052
67regulation of mast cell activation (GO:0033003)3.12835672
68high-density lipoprotein particle remodeling (GO:0034375)3.12178036
69positive regulation of lipid catabolic process (GO:0050996)3.11648027
70negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.11409623
71positive regulation of fatty acid beta-oxidation (GO:0032000)3.10340267
72angiogenesis involved in wound healing (GO:0060055)3.09821397
73regulation of complement activation (GO:0030449)3.09101633
74urea cycle (GO:0000050)3.07831777
75urea metabolic process (GO:0019627)3.07831777
76negative regulation of fibrinolysis (GO:0051918)3.07350910
77ethanol oxidation (GO:0006069)3.05827956
78protein-lipid complex assembly (GO:0065005)3.05236298
79acylglycerol homeostasis (GO:0055090)3.03640344
80triglyceride homeostasis (GO:0070328)3.03640344
81peptidyl-glutamic acid carboxylation (GO:0017187)3.02549540
82protein carboxylation (GO:0018214)3.02549540
83positive regulation of fatty acid oxidation (GO:0046321)3.00964567
84positive regulation of mast cell degranulation (GO:0043306)3.00234796
85positive regulation of mast cell activation involved in immune response (GO:0033008)3.00234796
86dicarboxylic acid biosynthetic process (GO:0043650)2.98616265
87cofactor catabolic process (GO:0051187)2.97518162
88microglial cell activation (GO:0001774)2.97220858
89regulation of mast cell activation involved in immune response (GO:0033006)2.97146112
90tryptophan metabolic process (GO:0006568)2.96424105
91glutamate metabolic process (GO:0006536)2.95643302
92nitrogen cycle metabolic process (GO:0071941)2.93420322
93myeloid cell activation involved in immune response (GO:0002275)2.93294478
94positive regulation by symbiont of host defense response (GO:0052509)2.92549723
95modulation by symbiont of host defense response (GO:0052031)2.92549723
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92549723
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92549723
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.92549723
99modulation by symbiont of host immune response (GO:0052553)2.92549723
100reverse cholesterol transport (GO:0043691)2.92014515
101alpha-amino acid catabolic process (GO:1901606)2.90942983
102bile acid metabolic process (GO:0008206)2.90437557
103negative regulation of platelet activation (GO:0010544)2.89676296
104response to peptidoglycan (GO:0032494)2.89355463
105immunoglobulin mediated immune response (GO:0016064)2.88466892
106negative regulation of interleukin-12 production (GO:0032695)2.88279900
107negative regulation of homotypic cell-cell adhesion (GO:0034111)2.87435263
108regulation of fibrinolysis (GO:0051917)2.87035172
109lipoxygenase pathway (GO:0019372)2.86740869
110branched-chain amino acid catabolic process (GO:0009083)2.86244393
111phospholipid efflux (GO:0033700)2.86206563
112regulation of fatty acid oxidation (GO:0046320)2.84495869
113detection of other organism (GO:0098543)2.83414256
114negative regulation of erythrocyte differentiation (GO:0045647)2.82428787
115carboxylic acid catabolic process (GO:0046395)2.81979958
116organic acid catabolic process (GO:0016054)2.81979958
117platelet aggregation (GO:0070527)2.81560118
118plasma lipoprotein particle remodeling (GO:0034369)2.81508305
119protein-lipid complex remodeling (GO:0034368)2.81508305
120macromolecular complex remodeling (GO:0034367)2.81508305
121macrophage activation involved in immune response (GO:0002281)2.80624281
122neutral lipid catabolic process (GO:0046461)2.80077559
123acylglycerol catabolic process (GO:0046464)2.80077559
124branched-chain amino acid metabolic process (GO:0009081)2.79954752
125response to mercury ion (GO:0046689)2.79430141
126biotin metabolic process (GO:0006768)2.79043058
127cellular amino acid catabolic process (GO:0009063)2.77822630
128quaternary ammonium group transport (GO:0015697)2.77812950
129leukocyte degranulation (GO:0043299)2.77391556
130coenzyme catabolic process (GO:0009109)2.77385740
131triglyceride catabolic process (GO:0019433)2.77169154
132regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76789097
133regulation of cholesterol esterification (GO:0010872)2.76596736
134positive regulation of cellular amide metabolic process (GO:0034250)2.76134404
135positive regulation of triglyceride metabolic process (GO:0090208)2.74863080
136ketone body metabolic process (GO:1902224)2.74751943
137regulation of integrin-mediated signaling pathway (GO:2001044)2.74732360
138tetrapyrrole metabolic process (GO:0033013)2.74494520
139oxaloacetate metabolic process (GO:0006107)2.74390068
140detection of bacterium (GO:0016045)2.73773571
141phospholipid homeostasis (GO:0055091)2.72487711
142negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.72059209
143plasma lipoprotein particle organization (GO:0071827)2.71167202
144heme transport (GO:0015886)2.69858274
145regulation of B cell receptor signaling pathway (GO:0050855)2.68079737
146regulation of homotypic cell-cell adhesion (GO:0034110)2.67736419
147regulation of leukocyte degranulation (GO:0043300)2.65893134
148G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.64354426
149regulation of T-helper 2 cell differentiation (GO:0045628)2.64164234
150blood coagulation, intrinsic pathway (GO:0007597)2.60677070
151purinergic receptor signaling pathway (GO:0035587)2.59780550
152G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.58349052
153antigen processing and presentation of endogenous antigen (GO:0019883)2.57769378
154cellular extravasation (GO:0045123)2.56720800
155negative regulation of T-helper cell differentiation (GO:0045623)2.56531468
156negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.56531468
157positive regulation of receptor recycling (GO:0001921)2.56363866
158purinergic nucleotide receptor signaling pathway (GO:0035590)2.54919606
159protein neddylation (GO:0045116)2.54489926
160actin filament polymerization (GO:0030041)2.52404095
161positive regulation of type 2 immune response (GO:0002830)2.46716067
162autophagic vacuole fusion (GO:0000046)2.46084789
163macrophage activation (GO:0042116)2.45141381
164regulation of regulatory T cell differentiation (GO:0045589)2.44538245
165antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42188458
166regulation of T-helper 1 cell differentiation (GO:0045625)2.41314971
167regulation of macrophage derived foam cell differentiation (GO:0010743)2.40997307
168superoxide anion generation (GO:0042554)2.40555055
169regulation of regulated secretory pathway (GO:1903305)2.40389802
170positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.38369885
171cellular response to thyroid hormone stimulus (GO:0097067)2.37884732
172positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.37197199
173positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.36696582
174negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.36597407
175B cell mediated immunity (GO:0019724)2.35529920
176positive regulation of macrophage differentiation (GO:0045651)2.35086915
177megakaryocyte development (GO:0035855)2.32695143
178positive regulation of endothelial cell differentiation (GO:0045603)2.32218930
179Arp2/3 complex-mediated actin nucleation (GO:0034314)2.31261257
180negative regulation of interleukin-17 production (GO:0032700)2.28669658
181phagosome maturation (GO:0090382)2.27600705
182detection of external biotic stimulus (GO:0098581)2.27594030
183regulation of gamma-delta T cell activation (GO:0046643)2.27486846
184positive regulation of immunoglobulin mediated immune response (GO:0002891)2.25660225
185positive regulation of B cell mediated immunity (GO:0002714)2.25660225
186regulation of MHC class II biosynthetic process (GO:0045346)2.25283814
187positive regulation of cAMP-mediated signaling (GO:0043950)2.25260728
188positive regulation of hemostasis (GO:1900048)2.23852041
189positive regulation of blood coagulation (GO:0030194)2.23852041
190positive regulation of toll-like receptor signaling pathway (GO:0034123)2.22876027
191cellular response to epinephrine stimulus (GO:0071872)2.22801796
192platelet activation (GO:0030168)2.22477586
193germinal center formation (GO:0002467)2.21152536
194regulation of interleukin-17 production (GO:0032660)2.19206031
195dendritic cell chemotaxis (GO:0002407)2.18577932
196response to host immune response (GO:0052572)2.17444335
197response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.17444335
198interferon-gamma-mediated signaling pathway (GO:0060333)2.17166470
199positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.17079927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.79861396
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.86523153
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.75922308
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.08880999
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.83361130
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.44089172
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.27635408
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.15547146
9GATA1_22025678_ChIP-Seq_K562_Human3.11368215
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.00017443
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.77937220
12GATA1_19941826_ChIP-Seq_K562_Human2.63778331
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.58309630
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50844086
15GATA1_19941827_ChIP-Seq_MEL_Mouse2.19450794
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.17097322
17IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98728017
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.94498590
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94082073
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92455005
21MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88369545
22KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.84838410
23GATA2_19941826_ChIP-Seq_K562_Human1.79976027
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77263990
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.74999632
26TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.74188319
27EZH2_22144423_ChIP-Seq_EOC_Human1.63391955
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61536397
29VDR_24763502_ChIP-Seq_THP-1_Human1.49535259
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44623982
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43459744
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42276944
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38361615
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38193920
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38160803
36LXR_22292898_ChIP-Seq_THP-1_Human1.37580618
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35460061
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34681179
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33069803
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30227360
41VDR_24787735_ChIP-Seq_THP-1_Human1.28081408
42CLOCK_20551151_ChIP-Seq_293T_Human1.27549151
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25548911
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25529013
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23632207
46SPI1_23547873_ChIP-Seq_NB4_Human1.23297475
47ZNF263_19887448_ChIP-Seq_K562_Human1.22959558
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22956801
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.20807221
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.17633070
51UTX_26944678_Chip-Seq_JUKART_Human1.16890184
52SCL_19346495_ChIP-Seq_HPC-7_Human1.16734002
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16018535
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12755185
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12705145
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.12663531
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.12663531
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.11444928
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.10819174
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10247403
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.08981135
62EGR1_19032775_ChIP-ChIP_M12_Human1.08591921
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07852377
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07614813
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04231515
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.03382112
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02672864
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02552613
69TCF7_22412390_ChIP-Seq_EML_Mouse1.02239635
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00319366
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00278003
72GATA3_27048872_Chip-Seq_THYMUS_Human1.00222443
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98860771
74ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98732243
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97542307
76MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96424174
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95913405
78RUNX_20019798_ChIP-Seq_JUKART_Human0.95580142
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95032205
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94756550
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94244053
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93614325
83MYB_26560356_Chip-Seq_TH2_Human0.93266067
84STAT1_20625510_ChIP-Seq_HELA_Human0.93238922
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92323564
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91700548
87KDM2B_26808549_Chip-Seq_K562_Human0.90744604
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89737188
89EP300_21415370_ChIP-Seq_HL-1_Mouse0.89348007
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88778650
91ERG_21242973_ChIP-ChIP_JURKAT_Human0.88579787
92KDM2B_26808549_Chip-Seq_DND41_Human0.88195185
93GATA3_26560356_Chip-Seq_TH2_Human0.88071978
94CTCF_27219007_Chip-Seq_Bcells_Human0.86978837
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86897206
96BCL6_27268052_Chip-Seq_Bcells_Human0.86747332
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86258682
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86096978
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85677332
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85176720
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85040012
102VDR_21846776_ChIP-Seq_THP-1_Human0.84640346
103PU_27001747_Chip-Seq_BMDM_Mouse0.84570131
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84339337
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83694765
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83142196
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82880379
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81983021
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81109727
110BCOR_27268052_Chip-Seq_Bcells_Human0.80645085
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80140134
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79680775
113DROSHA_22980978_ChIP-Seq_HELA_Human0.78884093
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78577528
115MAF_26560356_Chip-Seq_TH1_Human0.76888693
116P68_20966046_ChIP-Seq_HELA_Human0.76822956
117MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.76537664
118FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76416971
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76020457
120GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75381234
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.75346206
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75270820
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75214431
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74958352
125SPI1_20517297_ChIP-Seq_HL60_Human0.74841474
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73182767
127MAF_26560356_Chip-Seq_TH2_Human0.72911544
128NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.72667724
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72380547
130RACK7_27058665_Chip-Seq_MCF-7_Human0.71181954
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.71083998
132IRF8_27001747_Chip-Seq_BMDM_Mouse0.70190686
133CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70174429
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.69889140
135TAF2_19829295_ChIP-Seq_ESCs_Human0.69777140
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.69738290
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.69140985
138HNF4A_19822575_ChIP-Seq_HepG2_Human0.68991418
139SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.68204046
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67846243
141SPI1_23127762_ChIP-Seq_K562_Human0.67713109
142BRD4_27068464_Chip-Seq_AML-cells_Mouse0.67425792
143KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67284783
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.66803307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.94275804
2MP0003656_abnormal_erythrocyte_physiolo4.60450093
3MP0005360_urolithiasis4.17781510
4MP0003303_peritoneal_inflammation3.56567427
5MP0005085_abnormal_gallbladder_physiolo3.47258551
6MP0004147_increased_porphyrin_level3.46591121
7MP0002837_dystrophic_cardiac_calcinosis3.21124931
8MP0005365_abnormal_bile_salt3.20270348
9MP0005083_abnormal_biliary_tract3.01343594
10MP0008004_abnormal_stomach_pH2.97201226
11MP0008875_abnormal_xenobiotic_pharmacok2.82802515
12MP0003436_decreased_susceptibility_to2.70302607
13MP0001835_abnormal_antigen_presentation2.60694835
14MP0010329_abnormal_lipoprotein_level2.49400471
15MP0004130_abnormal_muscle_cell2.46006268
16MP0003191_abnormal_cellular_cholesterol2.43833626
17MP0005671_abnormal_response_to2.34610041
18MP0003806_abnormal_nucleotide_metabolis2.32817446
19MP0002148_abnormal_hypersensitivity_rea2.31595681
20MP0005000_abnormal_immune_tolerance2.21264694
21MP0000465_gastrointestinal_hemorrhage2.19789267
22MP0003646_muscle_fatigue2.12104933
23MP0002419_abnormal_innate_immunity2.09242857
24MP0006082_CNS_inflammation2.01635066
25MP0009785_altered_susceptibility_to2.01238982
26MP0001790_abnormal_immune_system2.01018023
27MP0005387_immune_system_phenotype2.01018023
28MP0005332_abnormal_amino_acid2.00453792
29MP0009840_abnormal_foam_cell1.99261443
30MP0003252_abnormal_bile_duct1.95461434
31MP0005025_abnormal_response_to1.95113750
32MP0003172_abnormal_lysosome_physiology1.89778129
33MP0002118_abnormal_lipid_homeostasis1.84506570
34MP0000751_myopathy1.82242219
35MP0001533_abnormal_skeleton_physiology1.80367523
36MP0002723_abnormal_immune_serum1.79410088
37MP0006036_abnormal_mitochondrial_physio1.79148139
38MP0003195_calcinosis1.78415079
39MP0003329_amyloid_beta_deposits1.76445958
40MP0001800_abnormal_humoral_immune1.75470660
41MP0005584_abnormal_enzyme/coenzyme_acti1.74674710
42MP0002452_abnormal_antigen_presenting1.67668276
43MP0000609_abnormal_liver_physiology1.65555263
44MP0005670_abnormal_white_adipose1.64559503
45MP0000604_amyloidosis1.63688602
46MP0000749_muscle_degeneration1.61438153
47MP0003828_pulmonary_edema1.60265141
48MP0002420_abnormal_adaptive_immunity1.58477313
49MP0001819_abnormal_immune_cell1.56516337
50MP0010155_abnormal_intestine_physiology1.55987012
51MP0004215_abnormal_myocardial_fiber1.53941785
52MP0005535_abnormal_body_temperature1.47104541
53MP0005319_abnormal_enzyme/_coenzyme1.44660468
54MP0005636_abnormal_mineral_homeostasis1.41876999
55MP0005330_cardiomyopathy1.41560763
56MP0004510_myositis1.41531515
57MP0005666_abnormal_adipose_tissue1.40266017
58MP0001666_abnormal_nutrient_absorption1.39031736
59MP0002971_abnormal_brown_adipose1.38883536
60MP0001545_abnormal_hematopoietic_system1.38384951
61MP0005397_hematopoietic_system_phenotyp1.38384951
62MP0001845_abnormal_inflammatory_respons1.37002779
63MP0003879_abnormal_hair_cell1.34643770
64MP0004036_abnormal_muscle_relaxation1.33771134
65MP0004947_skin_inflammation1.29751840
66MP0008775_abnormal_heart_ventricle1.27859547
67MP0009764_decreased_sensitivity_to1.23986104
68MP0009643_abnormal_urine_homeostasis1.23936513
69MP0002398_abnormal_bone_marrow1.19917719
70MP0003186_abnormal_redox_activity1.19654398
71MP0002138_abnormal_hepatobiliary_system1.19063395
72MP0003690_abnormal_glial_cell1.17620626
73MP0005451_abnormal_body_composition1.16771754
74MP0009278_abnormal_bone_marrow1.15558780
75MP0001851_eye_inflammation1.15289129
76MP0001663_abnormal_digestive_system1.15027946
77MP0002972_abnormal_cardiac_muscle1.13701186
78MP0002998_abnormal_bone_remodeling1.13544096
79MP0002405_respiratory_system_inflammati1.13454305
80MP0000716_abnormal_immune_system1.13453150
81MP0005167_abnormal_blood-brain_barrier1.13163591
82MP0000747_muscle_weakness1.11919413
83MP0004087_abnormal_muscle_fiber1.11452070
84MP0002822_catalepsy1.08303948
85MP0005620_abnormal_muscle_contractility1.07511311
86MP0000249_abnormal_blood_vessel1.07345877
87MP0000858_altered_metastatic_potential1.06779358
88MP0004185_abnormal_adipocyte_glucose1.06090586
89MP0004084_abnormal_cardiac_muscle1.05415882
90MP0008260_abnormal_autophagy1.02880701
91MP0003724_increased_susceptibility_to1.02535626
92MP0003866_abnormal_defecation1.01517172
93MP0009333_abnormal_splenocyte_physiolog1.00570115
94MP0000689_abnormal_spleen_morphology1.00110962
95MP0005334_abnormal_fat_pad0.99626708
96MP0003075_altered_response_to0.99599283
97MP0005385_cardiovascular_system_phenoty0.99531888
98MP0001544_abnormal_cardiovascular_syste0.99531888
99MP0004859_abnormal_synaptic_plasticity0.98746798
100MP0005058_abnormal_lysosome_morphology0.98180480
101MP0001764_abnormal_homeostasis0.97679370
102MP0002429_abnormal_blood_cell0.95279118
103MP0000920_abnormal_myelination0.94540073
104MP0009763_increased_sensitivity_to0.94497656
105MP0004883_abnormal_blood_vessel0.94344602
106MP0008874_decreased_physiological_sensi0.94306475
107MP0005310_abnormal_salivary_gland0.93704604
108MP0005165_increased_susceptibility_to0.92842880
109MP0003638_abnormal_response/metabolism_0.92267704
110MP0006138_congestive_heart_failure0.91170777
111MP0005464_abnormal_platelet_physiology0.91036909
112MP0004019_abnormal_vitamin_homeostasis0.91000261
113MP0002078_abnormal_glucose_homeostasis0.90043712
114MP0008469_abnormal_protein_level0.88868930
115MP0000343_altered_response_to0.88332010
116MP0003633_abnormal_nervous_system0.87631939
117MP0005084_abnormal_gallbladder_morpholo0.86955793
118MP0005375_adipose_tissue_phenotype0.86495323
119MP0002722_abnormal_immune_system0.85932581
120MP0001756_abnormal_urination0.85303886
121MP0003011_delayed_dark_adaptation0.84473921
122MP0002269_muscular_atrophy0.84299337
123MP0000685_abnormal_immune_system0.83399000
124MP0010368_abnormal_lymphatic_system0.82637956
125MP0004484_altered_response_of0.82516348
126MP0002909_abnormal_adrenal_gland0.82207901
127MP0004145_abnormal_muscle_electrophysio0.81924095
128MP0002132_abnormal_respiratory_system0.81481543
129MP0008872_abnormal_physiological_respon0.81308214
130MP0002332_abnormal_exercise_endurance0.80637695
131MP0001970_abnormal_pain_threshold0.80239609
132MP0006035_abnormal_mitochondrial_morpho0.79111376
133MP0004085_abnormal_heartbeat0.78951601
134MP0000230_abnormal_systemic_arterial0.78221760
135MP0004043_abnormal_pH_regulation0.78203109
136MP0003183_abnormal_peptide_metabolism0.78147257
137MP0003763_abnormal_thymus_physiology0.77300528
138MP0009642_abnormal_blood_homeostasis0.76981540
139MP0002735_abnormal_chemical_nociception0.76586309
140MP0000759_abnormal_skeletal_muscle0.75553273
141MP0005164_abnormal_response_to0.74483785
142MP0003137_abnormal_impulse_conducting0.74017784
143MP0009765_abnormal_xenobiotic_induced0.73345402
144MP0006054_spinal_hemorrhage0.72634188
145MP0000598_abnormal_liver_morphology0.72355506
146MP0005166_decreased_susceptibility_to0.72262929
147MP0001765_abnormal_ion_homeostasis0.72175046
148MP0000015_abnormal_ear_pigmentation0.70617785
149MP0005448_abnormal_energy_balance0.69667881
150MP0002736_abnormal_nociception_after0.68763406
151MP0003300_gastrointestinal_ulcer0.68597851
152MP0003448_altered_tumor_morphology0.68584684
153MP0010630_abnormal_cardiac_muscle0.67973911
154MP0005381_digestive/alimentary_phenotyp0.67635457
155MP0002106_abnormal_muscle_physiology0.65292007
156MP0001968_abnormal_touch/_nociception0.64517714
157MP0002733_abnormal_thermal_nociception0.64175208
158MP0002876_abnormal_thyroid_physiology0.63701260

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.43538232
2Petechiae (HP:0000967)6.52305805
3Purpura (HP:0000979)6.36082379
4Menorrhagia (HP:0000132)5.79214048
5Abnormal platelet volume (HP:0011876)5.61191415
6Increased mean platelet volume (HP:0011877)5.54721990
7Epistaxis (HP:0000421)5.27734211
8Poikilocytosis (HP:0004447)4.96153943
9Gingival bleeding (HP:0000225)4.77680773
10Cholelithiasis (HP:0001081)4.54711707
11Abnormal gallbladder morphology (HP:0012437)4.22169338
12Abnormality of macrophages (HP:0004311)4.19599397
13Spontaneous hematomas (HP:0007420)4.09203816
14Abnormality of the heme biosynthetic pathway (HP:0010472)4.01674238
15Deep venous thrombosis (HP:0002625)3.98073212
16Hypochromic microcytic anemia (HP:0004840)3.88884318
17Stomatitis (HP:0010280)3.88765537
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.77341900
19Xanthomatosis (HP:0000991)3.74504655
20Acanthocytosis (HP:0001927)3.72931412
21Eczematoid dermatitis (HP:0000976)3.70085454
22Hyperbilirubinemia (HP:0002904)3.67828030
23Reticulocytosis (HP:0001923)3.60325762
24Abnormality of fatty-acid metabolism (HP:0004359)3.54931980
25Intrahepatic cholestasis (HP:0001406)3.53042866
26Abnormal gallbladder physiology (HP:0012438)3.49135969
27Cholecystitis (HP:0001082)3.49135969
28Recurrent abscess formation (HP:0002722)3.48157937
29Ketosis (HP:0001946)3.40044779
30Hyperlipoproteinemia (HP:0010980)3.38111950
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35783068
32Complement deficiency (HP:0004431)3.35747492
33Abnormal platelet function (HP:0011869)3.35402665
34Impaired platelet aggregation (HP:0003540)3.35402665
35Recurrent bacterial skin infections (HP:0005406)3.32353140
36Hyperammonemia (HP:0001987)3.31305266
37Exercise-induced myalgia (HP:0003738)3.30421981
38Myoglobinuria (HP:0002913)3.29467818
39Myositis (HP:0100614)3.11649565
40Abnormality of glycolipid metabolism (HP:0010969)3.07188082
41Abnormality of liposaccharide metabolism (HP:0010968)3.07188082
42Abnormality of glycosphingolipid metabolism (HP:0004343)3.07188082
43Abnormality of the gallbladder (HP:0005264)3.02882608
44Orchitis (HP:0100796)2.96674593
45Ketoacidosis (HP:0001993)2.96546323
46Dysostosis multiplex (HP:0000943)2.96392601
47Obstructive lung disease (HP:0006536)2.91610276
48Chronic obstructive pulmonary disease (HP:0006510)2.91610276
49Hypoglycemic coma (HP:0001325)2.90954903
50Recurrent gram-negative bacterial infections (HP:0005420)2.89806934
51Sudden death (HP:0001699)2.85401110
52Hypoalphalipoproteinemia (HP:0003233)2.82791063
53Optic neuritis (HP:0100653)2.82658458
54Retrobulbar optic neuritis (HP:0100654)2.82658458
55Hyperglycinuria (HP:0003108)2.82619115
56Increased cerebral lipofuscin (HP:0011813)2.82179297
57Elevated erythrocyte sedimentation rate (HP:0003565)2.80828980
58Prolonged partial thromboplastin time (HP:0003645)2.79662445
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.77497085
60Diaphragmatic weakness (HP:0009113)2.65350768
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62393966
62Dicarboxylic aciduria (HP:0003215)2.62393966
63Abnormality of glycine metabolism (HP:0010895)2.61478479
64Abnormality of serine family amino acid metabolism (HP:0010894)2.61478479
65Paralysis (HP:0003470)2.59937408
66Hyporeflexia of lower limbs (HP:0002600)2.59811907
67Metabolic acidosis (HP:0001942)2.59060724
68Exercise-induced muscle cramps (HP:0003710)2.58269511
69Episodic fever (HP:0001954)2.57289171
70Increased IgM level (HP:0003496)2.57059463
71Abnormality of complement system (HP:0005339)2.51618436
72Hepatosplenomegaly (HP:0001433)2.51426001
73Hypolipoproteinemia (HP:0010981)2.50403148
74Joint hemorrhage (HP:0005261)2.48597469
75Hypobetalipoproteinemia (HP:0003563)2.46872753
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.44037257
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.43218097
78Increased muscle lipid content (HP:0009058)2.41487151
79Polycythemia (HP:0001901)2.39967342
80Bruising susceptibility (HP:0000978)2.39930315
81Abnormality of the vasculature of the conjunctiva (HP:0008054)2.38742903
82Ventricular fibrillation (HP:0001663)2.38253503
83Abnormality of glutamine family amino acid metabolism (HP:0010902)2.37854927
84Mutism (HP:0002300)2.37284255
85Encephalitis (HP:0002383)2.36970866
86Diplopia (HP:0000651)2.36602925
87Abnormality of binocular vision (HP:0011514)2.36602925
88Chest pain (HP:0100749)2.35377443
89Hypertriglyceridemia (HP:0002155)2.33618591
90Arterial thrombosis (HP:0004420)2.30670996
91Cerebral edema (HP:0002181)2.29397862
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25137629
93Rhabdomyolysis (HP:0003201)2.23417979
94Cerebral hemorrhage (HP:0001342)2.23197210
95Vomiting (HP:0002013)2.23101489
96Vacuolated lymphocytes (HP:0001922)2.22706991
97Abnormality of the common coagulation pathway (HP:0010990)2.22249961
98Vertigo (HP:0002321)2.21085369
99Muscle stiffness (HP:0003552)2.20950065
100Abnormality of transition element cation homeostasis (HP:0011030)2.20665113
101Calf muscle hypertrophy (HP:0008981)2.18682042
102Gastrointestinal infarctions (HP:0005244)2.18075811
103Hyperglycinemia (HP:0002154)2.18030041
104Microcytic anemia (HP:0001935)2.17520074
105Global brain atrophy (HP:0002283)2.16763011
106Systemic lupus erythematosus (HP:0002725)2.16239367
107Conjunctival telangiectasia (HP:0000524)2.15813903
108Mediastinal lymphadenopathy (HP:0100721)2.15308409
109Hepatocellular carcinoma (HP:0001402)2.14536522
110Vasculitis (HP:0002633)2.14034673
111Muscle fiber splitting (HP:0003555)2.13576944
112Meningitis (HP:0001287)2.12289572
113Nausea (HP:0002018)2.11398988
114Pulmonary embolism (HP:0002204)2.10143874
115Hepatic necrosis (HP:0002605)2.09936635
116Joint swelling (HP:0001386)2.09756123
117Muscle hypertrophy of the lower extremities (HP:0008968)2.09646544
118Asymmetric septal hypertrophy (HP:0001670)2.08625794
119Hypercholesterolemia (HP:0003124)2.06084331
120Visual hallucinations (HP:0002367)2.05861614
121Axonal loss (HP:0003447)2.04452501
122Ventricular tachycardia (HP:0004756)2.04157866
123Lethargy (HP:0001254)2.04148958
124Recurrent fungal infections (HP:0002841)2.03782360
125Abnormality of purine metabolism (HP:0004352)2.01674501
126Amyloidosis (HP:0011034)2.01245568
127Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00817315
128Abnormality of polysaccharide metabolism (HP:0011012)2.00817315
129Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00817315
130Polyphagia (HP:0002591)1.99946930
131Generalized aminoaciduria (HP:0002909)1.99840749
132Epidermoid cyst (HP:0200040)1.99045447
133Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98183839
134Recurrent skin infections (HP:0001581)1.96811759
135Keratoconjunctivitis sicca (HP:0001097)1.96719062
136Gout (HP:0001997)1.96080235
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95300588
138Acute encephalopathy (HP:0006846)1.94585801
139Abnormality of lateral ventricle (HP:0030047)1.94501290
140Difficulty running (HP:0009046)1.94411361
141Sensorimotor neuropathy (HP:0007141)1.94352607
142Abnormal pupillary function (HP:0007686)1.94200698
143Hematochezia (HP:0002573)1.94041422
144Urticaria (HP:0001025)1.93641640
145Increased serum ferritin (HP:0003281)1.93121854
146Pulmonary infiltrates (HP:0002113)1.92533135
147Abnormality of sulfur amino acid metabolism (HP:0004339)1.91679720
148Leukocytosis (HP:0001974)1.88855669
149Gingivitis (HP:0000230)1.88306744
150Delayed CNS myelination (HP:0002188)1.87537139
151Myocardial infarction (HP:0001658)1.86190637
152Hemorrhage of the eye (HP:0011885)1.85585097
153Hemoptysis (HP:0002105)1.84269167
154Fat malabsorption (HP:0002630)1.83905842
155Loss of speech (HP:0002371)1.83743333
156Atrioventricular block (HP:0001678)1.83548403
157Abnormality of the Achilles tendon (HP:0005109)1.83463707
158Autoimmune hemolytic anemia (HP:0001890)1.82494454
159Keratoconjunctivitis (HP:0001096)1.82491880
160Bundle branch block (HP:0011710)1.82161503
161Abnormality of iron homeostasis (HP:0011031)1.82122006
162Inflammation of the large intestine (HP:0002037)1.82092842
163Hypochromic anemia (HP:0001931)1.81727616
164Status epilepticus (HP:0002133)1.81574076
165Neonatal onset (HP:0003623)1.81481544
166Palpitations (HP:0001962)1.80873928
167Mitral stenosis (HP:0001718)1.79870884
168Increased intramyocellular lipid droplets (HP:0012240)1.78945313
169Increased density of long bones (HP:0006392)1.77906973
170Oligomenorrhea (HP:0000876)1.77650535
171Urinary glycosaminoglycan excretion (HP:0003541)1.76763876
172Mucopolysacchariduria (HP:0008155)1.76763876
173Heart block (HP:0012722)1.76455784
174Cerebral palsy (HP:0100021)1.75968671
175Basal ganglia calcification (HP:0002135)1.75897690
176Abnormality of the intrinsic pathway (HP:0010989)1.75809270
177Skin nodule (HP:0200036)1.74760715
178Lipoatrophy (HP:0100578)1.74597298
179Abnormality of reticulocytes (HP:0004312)1.74282515
180Polyneuropathy (HP:0001271)1.72382233
181Autoimmune thrombocytopenia (HP:0001973)1.68357224
182Increased IgE level (HP:0003212)1.67509879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.73101424
2TRIB33.12014772
3DAPK22.34907824
4FES2.30993693
5TTN2.14743760
6PHKG12.13623834
7PHKG22.13623834
8TIE12.08715657
9BTK1.96824131
10OBSCN1.84199732
11LMTK21.84014661
12PINK11.83811797
13CSK1.78980754
14TEC1.78428264
15MYLK1.75245978
16KSR21.74686940
17PKN21.74500587
18FGFR41.72635386
19ERN11.69202866
20FGR1.66469163
21PDK31.64386642
22PDK41.64386642
23MAP3K31.59046799
24KDR1.58729784
25RIPK11.53699154
26CSF1R1.52293034
27SIK11.50320991
28HCK1.48622193
29ADRBK21.48423746
30MAP4K11.44156561
31TGFBR21.41680067
32IRAK41.33754585
33PTK2B1.33535893
34TBK11.30857588
35MAP3K71.30197764
36TAOK21.30110485
37MAP2K41.30022731
38JAK21.27258203
39JAK11.25877383
40MAPK111.25747770
41EPHB11.25641808
42BMPR21.22823681
43LYN1.21925345
44IKBKB1.21510195
45MAP3K131.20643451
46MST41.18172493
47GRK51.17053372
48RIPK41.16198115
49TESK21.13992441
50IKBKE1.13521454
51SIK31.09713855
52PRKCH1.08262848
53TYK21.07679334
54GRK71.06047848
55PRKAA21.04792881
56MUSK1.03078475
57ITK1.02246408
58PIK3CG1.00282078
59GRK60.99786340
60SGK30.99000325
61CAMKK20.97413297
62MAP3K110.96593462
63PIM20.93116991
64PRKAA10.92708933
65DAPK30.91131867
66DMPK0.90436806
67MAP3K120.89962266
68SGK4940.89672029
69SGK2230.89672029
70RET0.89332600
71NTRK10.88690039
72ARAF0.87995465
73TRPM70.86711150
74MAPK120.86486590
75PDPK10.86391953
76TLK10.86049470
77IRAK30.85472062
78CAMK1D0.85471325
79LCK0.85388788
80PRPF4B0.85002899
81PDK10.83787761
82WNK10.82956219
83EPHA40.79589239
84MAP2K10.79330361
85MAP3K20.79223966
86MATK0.77439979
87MAP3K10.77384733
88ZAP700.76692038
89PRKCQ0.75677273
90MAP2K30.74000172
91ABL20.73686723
92MAPKAPK30.72557816
93SYK0.71764045
94MARK30.71053693
95EPHA30.70905943
96MARK20.70498669
97ADRBK10.69779959
98MAP3K50.67116791
99CAMK2G0.67068722
100PRKACG0.65930808
101WNK40.65717508
102IRAK10.64697797
103TAOK10.63653543
104FYN0.62830052
105SCYL20.62513539
106FRK0.62296780
107ILK0.62061097
108STK40.62018780
109CAMKK10.61507232
110NEK90.61078276
111SIK20.59961514
112BMX0.59756710
113CAMK1G0.59715163
114HIPK20.59365804
115TNK20.58636091
116STK380.58188598
117ACVR1B0.58146377
118PAK60.57998658
119NTRK30.56890251
120SGK20.56522468
121PKN10.55732332
122KIT0.55139000
123INSRR0.54551662
124PAK30.52628279
125TXK0.52351752
126STK390.51949109
127PDK20.51303765
128PAK10.51257962
129PRKD10.50432146
130RAF10.49099006
131JAK30.47077835
132SGK10.46680984
133LRRK20.45648666
134EIF2AK10.44775022
135CDC42BPA0.44624727
136CDK50.44321114
137TAOK30.43719149
138MAP3K140.43623761
139BLK0.43024350
140CAMK2D0.42615180
141DYRK1B0.42487722
142PRKD30.42311001
143IRAK20.41521974
144MAP3K60.40800730
145PTK60.40308732
146CAMK10.39233150
147FER0.38568408
148TESK10.38227986
149PRKD20.37783547

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.20724932
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.18789602
3Nitrogen metabolism_Homo sapiens_hsa009103.13174726
4Fatty acid degradation_Homo sapiens_hsa000712.94952976
5Propanoate metabolism_Homo sapiens_hsa006402.79792985
6Platelet activation_Homo sapiens_hsa046112.72861512
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72540596
8Fatty acid metabolism_Homo sapiens_hsa012122.37387761
9Arginine biosynthesis_Homo sapiens_hsa002202.35357221
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26438268
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25626990
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.24656094
13PPAR signaling pathway_Homo sapiens_hsa033202.24340725
14Osteoclast differentiation_Homo sapiens_hsa043802.14638774
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.10717548
16Tryptophan metabolism_Homo sapiens_hsa003802.03781853
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00629089
18Butanoate metabolism_Homo sapiens_hsa006501.98742380
19Hematopoietic cell lineage_Homo sapiens_hsa046401.93388270
20Peroxisome_Homo sapiens_hsa041461.91795944
21Complement and coagulation cascades_Homo sapiens_hsa046101.88303079
22Allograft rejection_Homo sapiens_hsa053301.84100227
23Leishmaniasis_Homo sapiens_hsa051401.82860471
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80382000
25Graft-versus-host disease_Homo sapiens_hsa053321.79635300
26Pyruvate metabolism_Homo sapiens_hsa006201.77503358
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.73915235
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69490024
29Autoimmune thyroid disease_Homo sapiens_hsa053201.67830343
30beta-Alanine metabolism_Homo sapiens_hsa004101.64697549
31Chemokine signaling pathway_Homo sapiens_hsa040621.60857614
32Rheumatoid arthritis_Homo sapiens_hsa053231.60290619
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59155000
34Asthma_Homo sapiens_hsa053101.55269880
35Bile secretion_Homo sapiens_hsa049761.51980459
36Lysosome_Homo sapiens_hsa041421.50525946
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50232531
38Carbon metabolism_Homo sapiens_hsa012001.50001470
39Tuberculosis_Homo sapiens_hsa051521.49816996
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48543740
41Caffeine metabolism_Homo sapiens_hsa002321.47688925
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44327199
43B cell receptor signaling pathway_Homo sapiens_hsa046621.42668691
44Fatty acid elongation_Homo sapiens_hsa000621.42224272
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42047216
46Phagosome_Homo sapiens_hsa041451.41960792
47Staphylococcus aureus infection_Homo sapiens_hsa051501.39656784
48ABC transporters_Homo sapiens_hsa020101.38393298
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.37825688
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37725241
51Fatty acid biosynthesis_Homo sapiens_hsa000611.33220414
52Vitamin B6 metabolism_Homo sapiens_hsa007501.32014029
53Type I diabetes mellitus_Homo sapiens_hsa049401.30659254
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30322353
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.28277118
56Phenylalanine metabolism_Homo sapiens_hsa003601.15456564
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13892138
58Primary immunodeficiency_Homo sapiens_hsa053401.13575387
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11994840
60Arachidonic acid metabolism_Homo sapiens_hsa005901.09134710
61T cell receptor signaling pathway_Homo sapiens_hsa046601.08766783
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07292135
63Histidine metabolism_Homo sapiens_hsa003401.07249387
64Starch and sucrose metabolism_Homo sapiens_hsa005001.07067765
65Pertussis_Homo sapiens_hsa051331.07039337
66Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06938160
67Adipocytokine signaling pathway_Homo sapiens_hsa049201.04735680
68Vascular smooth muscle contraction_Homo sapiens_hsa042701.02973877
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01963492
70Viral myocarditis_Homo sapiens_hsa054161.01268228
71Glycerolipid metabolism_Homo sapiens_hsa005611.00906731
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00843061
73Other glycan degradation_Homo sapiens_hsa005110.98785375
74Endocytosis_Homo sapiens_hsa041440.98135454
75Salmonella infection_Homo sapiens_hsa051320.98075394
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95768783
77Chemical carcinogenesis_Homo sapiens_hsa052040.95633713
78Toxoplasmosis_Homo sapiens_hsa051450.93779603
79Sulfur metabolism_Homo sapiens_hsa009200.93108716
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92818125
81Sulfur relay system_Homo sapiens_hsa041220.92448847
82Shigellosis_Homo sapiens_hsa051310.91083682
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.90567587
84Tyrosine metabolism_Homo sapiens_hsa003500.90475501
85Cardiac muscle contraction_Homo sapiens_hsa042600.90335186
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90298732
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88919186
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87498816
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.87066608
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.86885375
91Legionellosis_Homo sapiens_hsa051340.86681380
92Morphine addiction_Homo sapiens_hsa050320.86636536
93African trypanosomiasis_Homo sapiens_hsa051430.86060314
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86006452
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85692000
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85468253
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84885915
98Biosynthesis of amino acids_Homo sapiens_hsa012300.84662793
99Parkinsons disease_Homo sapiens_hsa050120.84248529
100Fat digestion and absorption_Homo sapiens_hsa049750.82395969
101VEGF signaling pathway_Homo sapiens_hsa043700.81718304
102Antigen processing and presentation_Homo sapiens_hsa046120.80482595
103Oxidative phosphorylation_Homo sapiens_hsa001900.77805953
104TNF signaling pathway_Homo sapiens_hsa046680.77642986
105Serotonergic synapse_Homo sapiens_hsa047260.77400531
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76596314
107Circadian entrainment_Homo sapiens_hsa047130.74699455
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74236243
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.71501082
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69294220
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67395285
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66862677
113Long-term depression_Homo sapiens_hsa047300.66739327
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65550638
115Oxytocin signaling pathway_Homo sapiens_hsa049210.63454580
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63129105
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.62875722
118Influenza A_Homo sapiens_hsa051640.62755059
119Retinol metabolism_Homo sapiens_hsa008300.62717503
120Gap junction_Homo sapiens_hsa045400.62646838
121Insulin resistance_Homo sapiens_hsa049310.62232099
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.61760492
123Alzheimers disease_Homo sapiens_hsa050100.61086630
124Measles_Homo sapiens_hsa051620.61029718
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60862360
126Arginine and proline metabolism_Homo sapiens_hsa003300.60179016
127Amoebiasis_Homo sapiens_hsa051460.60088962
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60015020
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56855747
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.54004259
131Rap1 signaling pathway_Homo sapiens_hsa040150.53005649
132GnRH signaling pathway_Homo sapiens_hsa049120.51424185
133Acute myeloid leukemia_Homo sapiens_hsa052210.51044727
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50664659
135Regulation of autophagy_Homo sapiens_hsa041400.50638767
136Linoleic acid metabolism_Homo sapiens_hsa005910.50357333
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.49416727
138Cholinergic synapse_Homo sapiens_hsa047250.47234373
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.46547213
140AMPK signaling pathway_Homo sapiens_hsa041520.45218711
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44599847
142Selenocompound metabolism_Homo sapiens_hsa004500.44480886
143Pancreatic secretion_Homo sapiens_hsa049720.44346551
144Ras signaling pathway_Homo sapiens_hsa040140.43559857
145Systemic lupus erythematosus_Homo sapiens_hsa053220.43484939
146Insulin signaling pathway_Homo sapiens_hsa049100.42755717
147Collecting duct acid secretion_Homo sapiens_hsa049660.42697757
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42403315
149Pentose phosphate pathway_Homo sapiens_hsa000300.42351154
150Glucagon signaling pathway_Homo sapiens_hsa049220.42205913
151MAPK signaling pathway_Homo sapiens_hsa040100.42074187
152Dilated cardiomyopathy_Homo sapiens_hsa054140.41922481
153Long-term potentiation_Homo sapiens_hsa047200.41870633
154Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41866964
155Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37528385
156Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36105140
157Metabolic pathways_Homo sapiens_hsa011000.33647127
158Glutathione metabolism_Homo sapiens_hsa004800.32381960
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30622554
160Gastric acid secretion_Homo sapiens_hsa049710.30514472
161Lysine degradation_Homo sapiens_hsa003100.30455487
162Cyanoamino acid metabolism_Homo sapiens_hsa004600.27584422
163Renin secretion_Homo sapiens_hsa049240.26360712
164Vitamin digestion and absorption_Homo sapiens_hsa049770.25766518
165Type II diabetes mellitus_Homo sapiens_hsa049300.24064959
166Salivary secretion_Homo sapiens_hsa049700.23474433
167Prion diseases_Homo sapiens_hsa050200.22769505
168Olfactory transduction_Homo sapiens_hsa047400.22656114
169Synaptic vesicle cycle_Homo sapiens_hsa047210.21973012
170Fructose and mannose metabolism_Homo sapiens_hsa000510.21871366
171Folate biosynthesis_Homo sapiens_hsa007900.21226191
172Steroid biosynthesis_Homo sapiens_hsa001000.21103137
173Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17346267
174Calcium signaling pathway_Homo sapiens_hsa040200.16800685
175GABAergic synapse_Homo sapiens_hsa047270.16460773
176Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16122340
177Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14992939
178Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14251094
179Malaria_Homo sapiens_hsa051440.13585976

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