MARCH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound biosynthetic process (GO:0006779)9.93756365
2heme biosynthetic process (GO:0006783)9.56457397
3tachykinin receptor signaling pathway (GO:0007217)9.27375004
4tetrapyrrole biosynthetic process (GO:0033014)9.06495194
5porphyrin-containing compound metabolic process (GO:0006778)7.59725433
6heme metabolic process (GO:0042168)7.25420072
7positive regulation of digestive system process (GO:0060456)7.22317272
8erythrocyte maturation (GO:0043249)7.21496119
9hemoglobin metabolic process (GO:0020027)6.88539530
10response to methylmercury (GO:0051597)6.13521494
11erythrocyte development (GO:0048821)5.35453610
12regulation of somitogenesis (GO:0014807)5.33785826
13iron ion import (GO:0097286)5.16985677
14bicarbonate transport (GO:0015701)5.08620753
15regulation of germinal center formation (GO:0002634)5.01991120
16positive regulation of protein homooligomerization (GO:0032464)4.83823026
17tetrapyrrole metabolic process (GO:0033013)4.82373671
18response to lead ion (GO:0010288)4.44486529
19positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.29214101
20response to insecticide (GO:0017085)4.23773242
21negative regulation of systemic arterial blood pressure (GO:0003085)4.23274669
22negative regulation of smooth muscle cell differentiation (GO:0051151)4.18351563
23erythrocyte differentiation (GO:0030218)4.14834341
24positive regulation of p38MAPK cascade (GO:1900745)4.02800694
25response to arsenic-containing substance (GO:0046685)3.96052693
26nuclear pore complex assembly (GO:0051292)3.94682685
27myeloid cell development (GO:0061515)3.90535206
28import into cell (GO:0098657)3.85126185
29proteasome assembly (GO:0043248)3.83043203
30oxygen transport (GO:0015671)3.77568838
31establishment of skin barrier (GO:0061436)3.75598175
32negative regulation of stress fiber assembly (GO:0051497)3.71780798
33adrenergic receptor signaling pathway (GO:0071875)3.65294092
34regulation of interferon-gamma biosynthetic process (GO:0045072)3.62495611
35pigment biosynthetic process (GO:0046148)3.55250647
36pore complex assembly (GO:0046931)3.48925353
37positive regulation of T-helper 1 type immune response (GO:0002827)3.47443142
38adaptation of signaling pathway (GO:0023058)3.46249105
39very-low-density lipoprotein particle assembly (GO:0034379)3.44251154
40positive regulation of glomerulus development (GO:0090193)3.42772751
41platelet formation (GO:0030220)3.36723626
42histone H3-K36 demethylation (GO:0070544)3.33195560
43NAD biosynthetic process (GO:0009435)3.32158555
44ovulation from ovarian follicle (GO:0001542)3.30156117
45negative regulation of actin filament bundle assembly (GO:0032232)3.29107117
46one-carbon compound transport (GO:0019755)3.27765072
47regulation of apoptotic process involved in morphogenesis (GO:1902337)3.27521048
48ADP metabolic process (GO:0046031)3.26762403
49definitive hemopoiesis (GO:0060216)3.23102936
50rRNA catabolic process (GO:0016075)3.21660421
51response to histamine (GO:0034776)3.21101788
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.20329231
53regulation of T-helper 1 type immune response (GO:0002825)3.19813997
54embryonic hemopoiesis (GO:0035162)3.18303630
55positive regulation of chemokine biosynthetic process (GO:0045080)3.17961280
56regulation of water loss via skin (GO:0033561)3.16455583
57nuclear pore organization (GO:0006999)3.15273528
58negative regulation of viral entry into host cell (GO:0046597)3.14317466
59regulation of T-helper 1 cell differentiation (GO:0045625)3.11707824
60positive regulation of vasculogenesis (GO:2001214)3.11149243
61glomerular basement membrane development (GO:0032836)3.10042994
62regulation of response to osmotic stress (GO:0047484)3.08348544
63desmosome organization (GO:0002934)3.06118202
64AMP metabolic process (GO:0046033)3.04687109
65lipopolysaccharide biosynthetic process (GO:0009103)3.00989064
66purine-containing compound salvage (GO:0043101)3.00694834
67regulation of natural killer cell activation (GO:0032814)3.00054448
68positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.98344839
69negative regulation of metanephros development (GO:0072217)2.97525453
70water-soluble vitamin biosynthetic process (GO:0042364)2.92911516
71regulation of glomerulus development (GO:0090192)2.91779991
72daunorubicin metabolic process (GO:0044597)2.91401734
73polyketide metabolic process (GO:0030638)2.91401734
74doxorubicin metabolic process (GO:0044598)2.91401734
75activation of MAPKKK activity (GO:0000185)2.90610755
76positive regulation of defense response to virus by host (GO:0002230)2.89925515
77negative regulation of interleukin-8 production (GO:0032717)2.86180695
78pigment metabolic process (GO:0042440)2.84316679
79megakaryocyte development (GO:0035855)2.84293659
80granulocyte differentiation (GO:0030851)2.83512745
81blood vessel maturation (GO:0001955)2.78984979
82regulation of immunoglobulin secretion (GO:0051023)2.75555029
83branching involved in labyrinthine layer morphogenesis (GO:0060670)2.75320113
84gamma-aminobutyric acid signaling pathway (GO:0007214)2.74462678
85positive regulation of erythrocyte differentiation (GO:0045648)2.73014414
86negative regulation of lipid storage (GO:0010888)2.72730644
87cellular response to nicotine (GO:0071316)2.72303442
88peptide cross-linking (GO:0018149)2.72013846
89positive regulation by symbiont of host defense response (GO:0052509)2.70004998
90modulation by symbiont of host defense response (GO:0052031)2.70004998
91modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.70004998
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.70004998
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.70004998
94modulation by symbiont of host immune response (GO:0052553)2.70004998
95modulation by virus of host process (GO:0019054)2.69359424
96endothelium development (GO:0003158)2.69323611
97lipopolysaccharide metabolic process (GO:0008653)2.68120733
98metanephric mesenchyme development (GO:0072075)2.66904247
99protein-cofactor linkage (GO:0018065)2.65292654
100protein hydroxylation (GO:0018126)2.65115839
101negative regulation of granulocyte differentiation (GO:0030853)2.63893087
102regulation of interleukin-12 biosynthetic process (GO:0045075)2.63693356
103detection of light stimulus involved in sensory perception (GO:0050962)2.63375406
104detection of light stimulus involved in visual perception (GO:0050908)2.63375406
105regulation of erythrocyte differentiation (GO:0045646)2.62868859
106cellular response to exogenous dsRNA (GO:0071360)2.62100612
107regulation of chemokine biosynthetic process (GO:0045073)2.61608860
108fusion of sperm to egg plasma membrane (GO:0007342)2.60878666
109DNA deamination (GO:0045006)2.60730538
110snRNA processing (GO:0016180)2.60485299
111regulation of interferon-alpha production (GO:0032647)2.60109376
112heparin metabolic process (GO:0030202)2.59197143
113heparin biosynthetic process (GO:0030210)2.59197143
114actin filament capping (GO:0051693)2.59012915
115modulation by symbiont of host cellular process (GO:0044068)2.55980557
116positive regulation of cholesterol efflux (GO:0010875)2.55761330
117positive regulation of guanylate cyclase activity (GO:0031284)2.53494939
118positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52656590
119positive regulation of natural killer cell activation (GO:0032816)2.52272052
120response to cold (GO:0009409)2.52146833
121cellular response to arsenic-containing substance (GO:0071243)2.51634725
122regulation of digestive system process (GO:0044058)2.51373006
123flavonoid metabolic process (GO:0009812)2.50710963
124regulation of B cell receptor signaling pathway (GO:0050855)2.50349224
125regulation of interferon-beta biosynthetic process (GO:0045357)2.50252242
126detection of molecule of bacterial origin (GO:0032490)2.49519339
127cellular response to zinc ion (GO:0071294)2.49399959
128sphingosine metabolic process (GO:0006670)2.49387100
129positive regulation of interleukin-12 production (GO:0032735)2.49185574
130multicellular organism reproduction (GO:0032504)2.48534136
131energy homeostasis (GO:0097009)2.47897429
132metanephric epithelium development (GO:0072207)2.47505379
133plasma lipoprotein particle assembly (GO:0034377)2.47348502
134positive regulation of protein oligomerization (GO:0032461)2.46486161
135positive regulation of fibroblast migration (GO:0010763)2.46401178
136histone mRNA catabolic process (GO:0071044)2.46073913
137protein K11-linked deubiquitination (GO:0035871)2.44762721
138detection of external biotic stimulus (GO:0098581)2.44691148
139inner ear receptor cell development (GO:0060119)2.44254963
140regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.44178059
141otic vesicle formation (GO:0030916)2.44049095
142hyaluronan catabolic process (GO:0030214)2.43525511
143positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.43408094
144regulation of cytokine secretion involved in immune response (GO:0002739)2.43199892
145mesonephros development (GO:0001823)2.43160408
146regulation of transforming growth factor beta1 production (GO:0032908)2.41369110
147positive regulation of mitochondrial membrane permeability (GO:0035794)2.41192898
148kidney mesenchyme development (GO:0072074)2.40941251
149positive regulation of T-helper cell differentiation (GO:0045624)2.40871442
150plasma membrane fusion (GO:0045026)2.39706155
151decidualization (GO:0046697)2.39464634
152pyridine nucleotide biosynthetic process (GO:0019363)2.39212093
153nicotinamide nucleotide biosynthetic process (GO:0019359)2.39212093
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.38166309
155L-alpha-amino acid transmembrane transport (GO:1902475)2.37994235
156negative regulation of nitric oxide biosynthetic process (GO:0045019)2.37855723
157regulation of p38MAPK cascade (GO:1900744)2.37581769
158regulation of vasculogenesis (GO:2001212)2.36113566
159cellular response to dexamethasone stimulus (GO:0071549)2.35173726
160positive regulation of interferon-alpha production (GO:0032727)2.35026845
161detection of other organism (GO:0098543)2.34397218
162detection of bacterium (GO:0016045)2.34295340
163antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.33655344
164regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.33241211
165positive regulation of interferon-gamma production (GO:0032729)2.32829062
166regulation of natural killer cell differentiation (GO:0032823)2.30525500
167multicellular organismal water homeostasis (GO:0050891)2.29506049
168neuron remodeling (GO:0016322)2.24973284
169meiotic chromosome segregation (GO:0045132)2.24480638
170hemopoiesis (GO:0030097)2.20492751
171negative regulation of mast cell activation (GO:0033004)2.19594079
172iron ion homeostasis (GO:0055072)2.19257434
173tyrosine phosphorylation of STAT protein (GO:0007260)2.18711263
174DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.17559001
175regulation of activation of Janus kinase activity (GO:0010533)2.17373949
176gas transport (GO:0015669)2.16079352
177regulation of viral entry into host cell (GO:0046596)2.15493585
178embryonic camera-type eye morphogenesis (GO:0048596)2.15075649
179regulation of DNA endoreduplication (GO:0032875)2.14693352
180positive regulation of natural killer cell differentiation (GO:0032825)2.14620313
181response to host immune response (GO:0052572)2.14112855
182response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.14112855
183sphingoid metabolic process (GO:0046519)2.13475922
184protoporphyrinogen IX metabolic process (GO:0046501)15.5645481
185protoporphyrinogen IX biosynthetic process (GO:0006782)14.2052173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.07792272
2GATA1_22025678_ChIP-Seq_K562_Human4.39327967
3GATA1_19941826_ChIP-Seq_K562_Human4.38152373
4E2F7_22180533_ChIP-Seq_HELA_Human3.96949319
5TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.69289797
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.66755426
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.53637627
8KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.41055164
9SCL_19346495_ChIP-Seq_HPC-7_Human3.25927297
10STAT6_21828071_ChIP-Seq_BEAS2B_Human3.05803352
11GATA1_19941827_ChIP-Seq_MEL_Mouse2.99840389
12GATA2_19941826_ChIP-Seq_K562_Human2.95799203
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.87071837
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.53168621
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.38499505
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.95473245
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.95006879
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90809981
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89672358
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85248199
21GATA1_22383799_ChIP-Seq_G1ME_Mouse1.84723244
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84290899
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78227380
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.77181352
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71228478
26SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.69104917
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.67882444
28CDX2_22108803_ChIP-Seq_LS180_Human1.65575402
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64614753
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64030120
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63750623
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62594633
33AUTS2_25519132_ChIP-Seq_293T-REX_Human1.60405628
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60082567
35VDR_22108803_ChIP-Seq_LS180_Human1.58413976
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58239369
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57475548
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53412547
39JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52268538
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.52056087
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50080789
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.49391754
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47638015
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42058543
45GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41382148
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.40772216
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40569026
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.38274242
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37495799
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37295889
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37047375
52GATA3_26560356_Chip-Seq_TH2_Human1.37027074
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36720302
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.36523800
55P300_19829295_ChIP-Seq_ESCs_Human1.34949009
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32801999
57CBP_20019798_ChIP-Seq_JUKART_Human1.32790288
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32790288
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31922116
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30936960
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29413061
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.26424755
63CDX2_20551321_ChIP-Seq_CACO-2_Human1.24696520
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23840903
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23612453
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22646211
67ELK1_19687146_ChIP-ChIP_HELA_Human1.22608834
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22358749
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20964374
70ER_23166858_ChIP-Seq_MCF-7_Human1.19708207
71NCOR1_26117541_ChIP-Seq_K562_Human1.19160599
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.18843995
73SALL4_22934838_ChIP-ChIP_CD34+_Human1.18748996
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.18612714
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17342134
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16917528
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16756172
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.16697604
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.16508812
80STAT3_23295773_ChIP-Seq_U87_Human1.16271488
81TCF7_22412390_ChIP-Seq_EML_Mouse1.15782457
82HNFA_21074721_ChIP-Seq_CACO-2_Human1.15318069
83GBX2_23144817_ChIP-Seq_PC3_Human1.12165847
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11789073
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10975703
86NFYB_21822215_ChIP-Seq_K562_Human1.10099439
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10045390
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10045390
89PHF8_20622853_ChIP-Seq_HELA_Human1.10009514
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09430513
91BRD4_25478319_ChIP-Seq_HGPS_Human1.07552663
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06838618
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06838618
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06643805
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.06540272
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06274403
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06018743
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05648787
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05022632
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04568204
101MAF_26560356_Chip-Seq_TH1_Human1.04441068
102AR_21572438_ChIP-Seq_LNCaP_Human1.04010494
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03795524
104FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03204059
105MYB_26560356_Chip-Seq_TH2_Human1.02376428
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.01313625
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01253712
108CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00527316
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.00107161
110FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99647826
111FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99595289
112GATA6_21074721_ChIP-Seq_CACO-2_Human0.99516109
113GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99445326
114NFYA_21822215_ChIP-Seq_K562_Human0.98562766
115RBPJ_21746931_ChIP-Seq_IB4_Human0.98187181
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97153247
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96903128
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96187787
119TP53_22573176_ChIP-Seq_HFKS_Human0.95745260
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95241702
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94819509
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94128568
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94123990
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93615275
125VDR_24787735_ChIP-Seq_THP-1_Human0.93156421
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92950853
127UTX_26944678_Chip-Seq_JUKART_Human0.92570050
128KDM2B_26808549_Chip-Seq_K562_Human0.92374114
129VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91557909
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91294729
131RUNX_20019798_ChIP-Seq_JUKART_Human0.90043485
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89543633
133ETS1_22383799_ChIP-Seq_G1ME_Mouse0.89250944
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89134073
135CJUN_26792858_Chip-Seq_BT549_Human0.88997082
136ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87440259
137IRF8_21731497_ChIP-ChIP_J774_Mouse0.87029261
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86728028
139KLF5_25053715_ChIP-Seq_YYC3_Human0.86673183
140TP53_16413492_ChIP-PET_HCT116_Human0.86443712
141TP53_18474530_ChIP-ChIP_U2OS_Human0.85773434
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85615125
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85457676
144VDR_24763502_ChIP-Seq_THP-1_Human0.83413773
145P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83305524
146VDR_21846776_ChIP-Seq_THP-1_Human0.81860545
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81451087
148HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79480775
149RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78626017
150KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77799903
151RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77795790
152NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77539160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo8.27580225
2MP0004147_increased_porphyrin_level7.56937888
3MP0003195_calcinosis4.91863864
4MP0003878_abnormal_ear_physiology3.50737191
5MP0005377_hearing/vestibular/ear_phenot3.50737191
6MP0003303_peritoneal_inflammation2.92586082
7MP0005275_abnormal_skin_tensile2.84737162
8MP0008438_abnormal_cutaneous_collagen2.79609910
9MP0003705_abnormal_hypodermis_morpholog2.77273043
10MP0003300_gastrointestinal_ulcer2.58153104
11MP0005501_abnormal_skin_physiology2.43522993
12MP0002138_abnormal_hepatobiliary_system2.35771512
13MP0002332_abnormal_exercise_endurance2.32223878
14MP0002060_abnormal_skin_morphology2.17181471
15MP0001879_abnormal_lymphatic_vessel2.12469214
16MP0010368_abnormal_lymphatic_system2.11808737
17MP0001501_abnormal_sleep_pattern2.09778329
18MP0002009_preneoplasia2.02766153
19MP0005083_abnormal_biliary_tract1.97683747
20MP0005397_hematopoietic_system_phenotyp1.96382971
21MP0001545_abnormal_hematopoietic_system1.96382971
22MP0003011_delayed_dark_adaptation1.94784572
23MP0003566_abnormal_cell_adhesion1.94216168
24MP0002877_abnormal_melanocyte_morpholog1.79651308
25MP0006054_spinal_hemorrhage1.76347941
26MP0002796_impaired_skin_barrier1.75567307
27MP0002148_abnormal_hypersensitivity_rea1.75058171
28MP0000372_irregular_coat_pigmentation1.74997018
29MP0005076_abnormal_cell_differentiation1.71148446
30MP0005167_abnormal_blood-brain_barrier1.63999118
31MP0003941_abnormal_skin_development1.62261317
32MP0003279_aneurysm1.56961023
33MP0000685_abnormal_immune_system1.56362479
34MP0003111_abnormal_nucleus_morphology1.55975766
35MP0003786_premature_aging1.55101505
36MP0005310_abnormal_salivary_gland1.54411362
37MP0001835_abnormal_antigen_presentation1.53418127
38MP0003191_abnormal_cellular_cholesterol1.52067969
39MP0009931_abnormal_skin_appearance1.51805715
40MP0009785_altered_susceptibility_to1.47035696
41MP0010771_integument_phenotype1.45913734
42MP0010307_abnormal_tumor_latency1.43677880
43MP0005503_abnormal_tendon_morphology1.41901556
44MP0002132_abnormal_respiratory_system1.40966163
45MP0000343_altered_response_to1.38799762
46MP0000003_abnormal_adipose_tissue1.37897085
47MP0000015_abnormal_ear_pigmentation1.36771621
48MP0004947_skin_inflammation1.35400368
49MP0005387_immune_system_phenotype1.34744639
50MP0001790_abnormal_immune_system1.34744639
51MP0005636_abnormal_mineral_homeostasis1.34118681
52MP0005645_abnormal_hypothalamus_physiol1.29491771
53MP0002163_abnormal_gland_morphology1.27982419
54MP0005464_abnormal_platelet_physiology1.25593452
55MP0004484_altered_response_of1.24550538
56MP0002398_abnormal_bone_marrow1.23979310
57MP0004233_abnormal_muscle_weight1.22357495
58MP0008775_abnormal_heart_ventricle1.16428648
59MP0000579_abnormal_nail_morphology1.16197896
60MP0001191_abnormal_skin_condition1.15690341
61MP0004808_abnormal_hematopoietic_stem1.15296307
62MP0003453_abnormal_keratinocyte_physiol1.14686107
63MP0009384_cardiac_valve_regurgitation1.14619563
64MP0002254_reproductive_system_inflammat1.13891699
65MP0004215_abnormal_myocardial_fiber1.13668392
66MP0003221_abnormal_cardiomyocyte_apopto1.13400116
67MP0005671_abnormal_response_to1.12045259
68MP0003436_decreased_susceptibility_to1.11391512
69MP0002972_abnormal_cardiac_muscle1.11157009
70MP0005000_abnormal_immune_tolerance1.10074087
71MP0001800_abnormal_humoral_immune1.08023783
72MP0001216_abnormal_epidermal_layer1.07991940
73MP0003724_increased_susceptibility_to1.06847329
74MP0000465_gastrointestinal_hemorrhage1.06179080
75MP0009278_abnormal_bone_marrow1.05496978
76MP0004043_abnormal_pH_regulation1.04831037
77MP0002405_respiratory_system_inflammati1.04195950
78MP0005084_abnormal_gallbladder_morpholo1.03151775
79MP0002452_abnormal_antigen_presenting1.03061484
80MP0004185_abnormal_adipocyte_glucose1.02734622
81MP0004272_abnormal_basement_membrane1.01084112
82MP0002295_abnormal_pulmonary_circulatio0.98965806
83MP0002722_abnormal_immune_system0.97495846
84MP0005595_abnormal_vascular_smooth0.96324279
85MP0009764_decreased_sensitivity_to0.95986925
86MP0002102_abnormal_ear_morphology0.95288701
87MP0004510_myositis0.95017110
88MP0001243_abnormal_dermal_layer0.94577524
89MP0001661_extended_life_span0.92747947
90MP0000749_muscle_degeneration0.92676521
91MP0000490_abnormal_crypts_of0.91675150
92MP0003091_abnormal_cell_migration0.91330126
93MP0001873_stomach_inflammation0.91202763
94MP0005410_abnormal_fertilization0.90979742
95MP0010352_gastrointestinal_tract_polyps0.90693761
96MP0003828_pulmonary_edema0.89953988
97MP0006082_CNS_inflammation0.89910232
98MP0009697_abnormal_copulation0.89347156
99MP0002429_abnormal_blood_cell0.89265577
100MP0000858_altered_metastatic_potential0.89078991
101MP0000689_abnormal_spleen_morphology0.88944186
102MP0008961_abnormal_basal_metabolism0.88412232
103MP0002419_abnormal_innate_immunity0.88048453
104MP0003646_muscle_fatigue0.87619617
105MP0000230_abnormal_systemic_arterial0.87603431
106MP0001324_abnormal_eye_pigmentation0.87135678
107MP0001853_heart_inflammation0.86455480
108MP0002723_abnormal_immune_serum0.85708233
109MP0003186_abnormal_redox_activity0.85210255
110MP0002420_abnormal_adaptive_immunity0.84921016
111MP0008872_abnormal_physiological_respon0.84920548
112MP0008770_decreased_survivor_rate0.84713832
113MP0001819_abnormal_immune_cell0.84590585
114MP0005647_abnormal_sex_gland0.84226686
115MP0005253_abnormal_eye_physiology0.83685713
116MP0005360_urolithiasis0.83253425
117MP0005257_abnormal_intraocular_pressure0.82070029
118MP0001958_emphysema0.81811058
119MP0005375_adipose_tissue_phenotype0.81272617
120MP0000427_abnormal_hair_cycle0.81230034
121MP0002166_altered_tumor_susceptibility0.80938880
122MP0005508_abnormal_skeleton_morphology0.80690440
123MP0005551_abnormal_eye_electrophysiolog0.80341311
124MP0003763_abnormal_thymus_physiology0.80333532
125MP0000767_abnormal_smooth_muscle0.80264880
126MP0002168_other_aberrant_phenotype0.80249151
127MP0000371_diluted_coat_color0.79793018
128MP0005390_skeleton_phenotype0.78400005
129MP0004084_abnormal_cardiac_muscle0.77966907
130MP0002098_abnormal_vibrissa_morphology0.76926530
131MP0003283_abnormal_digestive_organ0.76101737
132MP0005197_abnormal_uvea_morphology0.75697434
133MP0005451_abnormal_body_composition0.75531971
134MP0002006_tumorigenesis0.75324512
135MP0005165_increased_susceptibility_to0.74702847
136MP0002933_joint_inflammation0.74630069
137MP0001533_abnormal_skeleton_physiology0.72140887
138MP0002396_abnormal_hematopoietic_system0.72125202
139MP0005334_abnormal_fat_pad0.71640422
140MP0006276_abnormal_autonomic_nervous0.71547549
141MP0005266_abnormal_metabolism0.70803824
142MP0008995_early_reproductive_senescence0.70263883
143MP0002277_abnormal_respiratory_mucosa0.69928927
144MP0000716_abnormal_immune_system0.69724626
145MP0003045_fibrosis0.67695126
146MP0005025_abnormal_response_to0.67646163
147MP0005621_abnormal_cell_physiology0.66924734
148MP0004085_abnormal_heartbeat0.66682349
149MP0003950_abnormal_plasma_membrane0.66138346
150MP0001845_abnormal_inflammatory_respons0.65218779
151MP0005171_absent_coat_pigmentation0.65194947
152MP0009333_abnormal_splenocyte_physiolog0.64926506
153MP0008004_abnormal_stomach_pH0.64616923
154MP0003448_altered_tumor_morphology0.64367962
155MP0005332_abnormal_amino_acid0.64031381
156MP0002998_abnormal_bone_remodeling0.63697059

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)7.77359897
2Hypochromic microcytic anemia (HP:0004840)7.72594984
3Reticulocytosis (HP:0001923)6.64372031
4Cholelithiasis (HP:0001081)5.37446689
5Diaphragmatic weakness (HP:0009113)5.03173144
6Abnormality of macular pigmentation (HP:0008002)5.02745861
7Osteomalacia (HP:0002749)5.00443184
8Abnormal gallbladder morphology (HP:0012437)4.89890793
9Paralysis (HP:0003470)4.88210755
10Decreased central vision (HP:0007663)4.26822196
11IgG deficiency (HP:0004315)4.07777352
12Abnormality of reticulocytes (HP:0004312)4.03984070
13Anhidrosis (HP:0000970)3.86454729
14Hyperbilirubinemia (HP:0002904)3.77849743
15Anomalous pulmonary venous return (HP:0010772)3.77547665
16Decreased electroretinogram (ERG) amplitude (HP:0000654)3.74291103
17Abnormality of the gallbladder (HP:0005264)3.70192617
18Microcytic anemia (HP:0001935)3.65943894
19Ileus (HP:0002595)3.61116350
20Hypochromic anemia (HP:0001931)3.52795358
21Albinism (HP:0001022)3.51336040
22Increased IgM level (HP:0003496)3.38624878
23Cutaneous photosensitivity (HP:0000992)3.35034317
24Abnormality of the pulmonary veins (HP:0011718)3.34814259
25Hypophosphatemic rickets (HP:0004912)3.30541914
26Premature rupture of membranes (HP:0001788)3.23818899
27Onycholysis (HP:0001806)3.23785870
28Attenuation of retinal blood vessels (HP:0007843)3.20013207
29Poikiloderma (HP:0001029)3.14931186
30Parakeratosis (HP:0001036)3.10865241
31Autoamputation (HP:0001218)3.08571864
32Urticaria (HP:0001025)3.07777789
33Abnormality of dental color (HP:0011073)3.06815336
34Conical tooth (HP:0000698)3.05981841
35Insomnia (HP:0100785)2.99989360
36Recurrent corneal erosions (HP:0000495)2.99232820
37Pustule (HP:0200039)2.95616237
38Recurrent pneumonia (HP:0006532)2.90685009
39Increased corneal curvature (HP:0100692)2.85395950
40Keratoconus (HP:0000563)2.85395950
41Abnormal gallbladder physiology (HP:0012438)2.80947062
42Cholecystitis (HP:0001082)2.80947062
43Cerebral hemorrhage (HP:0001342)2.72126793
44Nonimmune hydrops fetalis (HP:0001790)2.68775018
45Polycythemia (HP:0001901)2.64353330
46Choroideremia (HP:0001139)2.61511874
47Chorioretinal atrophy (HP:0000533)2.60199845
483-Methylglutaconic aciduria (HP:0003535)2.59234730
49Abnormality of incisor morphology (HP:0011063)2.57436523
50Optic neuritis (HP:0100653)2.56611540
51Retrobulbar optic neuritis (HP:0100654)2.56611540
52Corneal dystrophy (HP:0001131)2.56206469
53Abnormality of cochlea (HP:0000375)2.55433872
54Abnormality of nail color (HP:0100643)2.50343992
55Prolonged bleeding time (HP:0003010)2.49617068
56Petechiae (HP:0000967)2.48800607
57Autoimmune thrombocytopenia (HP:0001973)2.45892578
58Fragile skin (HP:0001030)2.44523197
59Progressive inability to walk (HP:0002505)2.40149767
60Corneal erosion (HP:0200020)2.37923830
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35230262
62Abnormality of alanine metabolism (HP:0010916)2.35230262
63Hyperalaninemia (HP:0003348)2.35230262
64Dyschromatopsia (HP:0007641)2.30932202
65Abnormality of T cell physiology (HP:0011840)2.30196841
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.29949100
67Ectropion (HP:0000656)2.28667833
68Macular degeneration (HP:0000608)2.25958313
69Hyponatremia (HP:0002902)2.25325572
70Autoimmune hemolytic anemia (HP:0001890)2.23923849
71Rectal prolapse (HP:0002035)2.22902215
72Prostate neoplasm (HP:0100787)2.21179731
73Abnormality of the intervertebral disk (HP:0005108)2.20695416
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19247482
75Nausea (HP:0002018)2.16787438
76Aortic aneurysm (HP:0004942)2.16040488
77Abnormal hemoglobin (HP:0011902)2.13620257
78Gastrointestinal stroma tumor (HP:0100723)2.12720092
79Short middle phalanx of the 5th finger (HP:0004220)2.12218293
80Posterior subcapsular cataract (HP:0007787)2.11827095
81Abnormality of chloride homeostasis (HP:0011422)2.10665642
82Renal tubular acidosis (HP:0001947)2.09628106
83Severe visual impairment (HP:0001141)2.09338560
84Recurrent lower respiratory tract infections (HP:0002783)2.08882826
85Congenital stationary night blindness (HP:0007642)2.08368800
86Absent speech (HP:0001344)2.07702244
87Orchitis (HP:0100796)2.07127609
88Blepharitis (HP:0000498)2.04627352
89Vertebral compression fractures (HP:0002953)2.03735458
90Lower limb amyotrophy (HP:0007210)2.01723398
91Poikilocytosis (HP:0004447)10.3503005
92Abnormality of the heme biosynthetic pathway (HP:0010472)10.1121759
93Hypoplastic left heart (HP:0004383)1.99960086
94Vasculitis (HP:0002633)1.96330317
95Eosinophilia (HP:0001880)1.94727454
96Gonadal dysgenesis (HP:0000133)1.94401577
97Carpal bone hypoplasia (HP:0001498)1.93427084
98Abnormality of sodium homeostasis (HP:0010931)1.93294096
99Abnormality of T cell number (HP:0011839)1.92782858
100Eczematoid dermatitis (HP:0000976)1.92655429
101Myocardial infarction (HP:0001658)1.92341447
102Protrusio acetabuli (HP:0003179)1.91386907
103Erythema (HP:0010783)1.91268713
104Keratitis (HP:0000491)1.91174742
105Increased serum ferritin (HP:0003281)1.90571415
106Methylmalonic aciduria (HP:0012120)1.89511538
107Abnormality of transition element cation homeostasis (HP:0011030)1.89390848
108Pathologic fracture (HP:0002756)1.89377404
109Hypoplastic heart (HP:0001961)1.88182149
110Lip pit (HP:0100267)1.87801619
111Rough bone trabeculation (HP:0100670)1.87052206
112Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87015416
113Episodic fever (HP:0001954)1.86853043
114Recurrent sinusitis (HP:0011108)1.85531409
115Confusion (HP:0001289)1.83871107
116Aortic dissection (HP:0002647)1.83724274
117Portal hypertension (HP:0001409)1.83703997
118Methylmalonic acidemia (HP:0002912)1.81573229
119Abnormality of the odontoid process (HP:0003310)1.81460559
120Azoospermia (HP:0000027)1.81234186
121Distal lower limb amyotrophy (HP:0008944)1.80834820
122Hypoplasia of the uterus (HP:0000013)1.78452281
123Upper limb muscle weakness (HP:0003484)1.77597181
124Aplasia/Hypoplasia of the earlobes (HP:0009906)1.77385190
125Follicular hyperkeratosis (HP:0007502)1.77308171
126Tetraparesis (HP:0002273)1.77162512
127Mitral stenosis (HP:0001718)1.75730055
128Epistaxis (HP:0000421)1.75235342
129Recurrent abscess formation (HP:0002722)1.74692062
130Type 2 muscle fiber atrophy (HP:0003554)1.74031021
131Muscle fiber splitting (HP:0003555)1.73715586
132Keratoconjunctivitis sicca (HP:0001097)1.73258930
133Hepatocellular carcinoma (HP:0001402)1.73070665
134Abnormality of iron homeostasis (HP:0011031)1.73005988
135Aplasia/hypoplasia of the uterus (HP:0008684)1.72965531
136Entropion (HP:0000621)1.70756730
137Subcapsular cataract (HP:0000523)1.69272193
138Dilatation of the ascending aorta (HP:0005111)1.69155498
139IgA deficiency (HP:0002720)1.68743817
140Keratoconjunctivitis (HP:0001096)1.68620715
141Erythroderma (HP:0001019)1.68452494
142Premature graying of hair (HP:0002216)1.68109340
143Hemorrhage of the eye (HP:0011885)1.67713620
144Right ventricular cardiomyopathy (HP:0011663)1.66985881
145Colitis (HP:0002583)1.66828200
146Alveolar cell carcinoma (HP:0006519)1.65543397
147Pulmonary fibrosis (HP:0002206)1.64657024
148True hermaphroditism (HP:0010459)1.64584494
149Type I transferrin isoform profile (HP:0003642)1.64504824
150Spontaneous hematomas (HP:0007420)1.64172212
151Lymphoma (HP:0002665)1.64163241
152Natal tooth (HP:0000695)1.63245014
153Myelomeningocele (HP:0002475)1.62529465
154Abnormal blistering of the skin (HP:0008066)1.61750390
155Constricted visual fields (HP:0001133)1.61664203
156Pancreatic cysts (HP:0001737)1.60246461
157Abnormality of the fingertips (HP:0001211)1.60080963
158Chromsome breakage (HP:0040012)1.60075435
159Abnormality of the hepatic vasculature (HP:0006707)1.60065346
160Small hand (HP:0200055)1.60009779
161Hyperkalemia (HP:0002153)1.59720424
162Pseudobulbar signs (HP:0002200)1.59696287
163Palmoplantar hyperkeratosis (HP:0000972)1.59350680
164Pulmonary infiltrates (HP:0002113)1.59284346
165Abnormality of the right ventricle (HP:0001707)1.58823020
166Peritonitis (HP:0002586)1.56392057
167Thin skin (HP:0000963)1.56294597
168Inflammation of the large intestine (HP:0002037)1.54240231
169Increased IgE level (HP:0003212)1.54051636
170Soft skin (HP:0000977)1.53297503
171Mesomelia (HP:0003027)1.49790391
172Hematochezia (HP:0002573)1.48817677
173Morphological abnormality of the inner ear (HP:0011390)1.48416369
174Birth length less than 3rd percentile (HP:0003561)1.46611830
175Abnormal platelet volume (HP:0011876)1.45838473
176Atrophic scars (HP:0001075)1.45442162
177Distal lower limb muscle weakness (HP:0009053)1.43769811
178Unilateral renal agenesis (HP:0000122)1.43058094
179Palmar hyperkeratosis (HP:0010765)1.42789325
180Increased mean platelet volume (HP:0011877)1.42008894
181Pruritus (HP:0000989)1.41907431
182Recurrent bacterial skin infections (HP:0005406)1.41203109
183Gingival bleeding (HP:0000225)1.40126344
184Alopecia of scalp (HP:0002293)1.39912016
185Increased connective tissue (HP:0009025)1.37708277
186Cerebral aneurysm (HP:0004944)1.34483129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.21203159
2TIE13.73898153
3LMTK23.68264720
4EIF2AK13.15095252
5TLK13.08705985
6ZAK2.71504747
7TAOK32.71242282
8IRAK32.63793536
9STK42.56641900
10PDK22.45011627
11FRK2.38733044
12BRD42.36273303
13SIK12.29235920
14STK102.28701573
15TRPM72.25555153
16EIF2AK32.18754636
17PIM12.11363465
18NEK62.06415814
19ADRBK21.94866628
20ACVR1B1.92718809
21MATK1.84445084
22MAP4K21.84150606
23ICK1.81077266
24TGFBR21.77240436
25NUAK11.72388863
26CASK1.71569927
27BCR1.66150145
28JAK31.60055981
29PLK41.59930396
30INSRR1.55754567
31LATS11.53698433
32CDK91.51853905
33MARK31.51021865
34STK31.45191590
35MAP3K141.42032351
36EIF2AK21.41415251
37EEF2K1.41310330
38TYK21.40461537
39JAK11.34635797
40DYRK31.29305263
41MAP3K121.28542896
42MELK1.23047369
43BMPR1B1.22621692
44SIK21.22592189
45BUB11.21693487
46IKBKB1.19928295
47TRIB31.19434097
48TEC1.17048418
49CSNK1A1L1.13991166
50BRSK11.13419329
51MAP3K41.12404994
52SIK31.09593352
53WNK11.08910051
54TAOK21.08729606
55CAMK1D1.08515810
56BMPR21.04544840
57MAPK111.02925696
58FLT31.02810517
59STK241.02796557
60CDK61.00258905
61IRAK10.96971948
62JAK20.96041535
63PINK10.94552539
64MAP2K60.92384692
65MAP3K60.91303252
66IRAK40.91230072
67SRPK10.91037244
68CDK40.90265383
69RPS6KA50.88307014
70MST40.87650082
71SYK0.85694110
72MYLK0.85180042
73CHUK0.83129994
74STK38L0.83124991
75CLK10.82222359
76TXK0.80189898
77CDC70.79213912
78IKBKE0.78662897
79PKN10.78601561
80SGK20.76034969
81BLK0.74465662
82GRK50.73388776
83TBK10.71958266
84MAP4K10.71761089
85SGK30.71679334
86PASK0.71418482
87NEK10.70289052
88PRKAA10.66414367
89GRK70.65799966
90OBSCN0.65227837
91VRK10.65046996
92MAP3K50.64496077
93MAPKAPK30.63272721
94BMX0.62422470
95PTK2B0.62373993
96ERN10.61384610
97PRKAA20.60887941
98PRKCQ0.60807400
99RAF10.59868862
100TGFBR10.59252613
101NEK20.58545426
102ADRBK10.58077682
103GRK10.57136063
104TAOK10.57064952
105PLK20.56556103
106HIPK20.55819205
107BRSK20.54304464
108MAP2K10.54043015
109GRK60.53384188
110LYN0.53206274
111CDC42BPA0.49143869
112PDGFRA0.48875464
113PIM20.48850129
114MOS0.48575731
115MAP2K70.48195626
116PIK3CG0.48078940
117HCK0.47946841
118DYRK1B0.47551332
119TTN0.46642751
120BCKDK0.46502135
121MAPKAPK20.46282609
122ROCK10.45792970
123MAP3K130.45655687
124MAP2K30.44367866
125ITK0.43986469
126CDK30.43207535
127NME10.43072426
128ERBB20.40357641
129SGK2230.40020906
130SGK4940.40020906
131INSR0.39723820
132KDR0.39452941
133IGF1R0.39337427
134PKN20.38698482
135ABL10.38307273
136MAPKAPK50.38028029
137AURKB0.36883862
138MAP3K110.36581475
139ATM0.35392585
140SGK10.34520021
141KIT0.32668281
142PRKG20.32048222
143NEK90.31738876
144MAP3K30.31006171
145EPHA30.30709155
146CAMK1G0.28497915
147CHEK20.28084249
148PRKCH0.28025169
149NLK0.27510859
150EPHB20.25854906
151MUSK0.25442093

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008606.44295043
2Systemic lupus erythematosus_Homo sapiens_hsa053224.50682626
3Vitamin B6 metabolism_Homo sapiens_hsa007503.54395543
4Nitrogen metabolism_Homo sapiens_hsa009103.52700792
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.30571706
6Asthma_Homo sapiens_hsa053102.87529552
7Malaria_Homo sapiens_hsa051442.45827846
8Alcoholism_Homo sapiens_hsa050342.38159844
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.33095298
10Graft-versus-host disease_Homo sapiens_hsa053322.19564571
11Hematopoietic cell lineage_Homo sapiens_hsa046402.03617639
12ABC transporters_Homo sapiens_hsa020102.01715361
13Sulfur metabolism_Homo sapiens_hsa009202.01037810
14Allograft rejection_Homo sapiens_hsa053301.83168941
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.82131480
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75390001
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.66057607
18Homologous recombination_Homo sapiens_hsa034401.65237498
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60516935
20Chronic myeloid leukemia_Homo sapiens_hsa052201.58538879
21p53 signaling pathway_Homo sapiens_hsa041151.58437336
22Tryptophan metabolism_Homo sapiens_hsa003801.54270822
23Pancreatic cancer_Homo sapiens_hsa052121.52279197
24Viral carcinogenesis_Homo sapiens_hsa052031.51216377
25Apoptosis_Homo sapiens_hsa042101.48639711
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48494720
27Small cell lung cancer_Homo sapiens_hsa052221.46861333
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45627766
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43493925
30Phototransduction_Homo sapiens_hsa047441.41374596
31Autoimmune thyroid disease_Homo sapiens_hsa053201.39870838
32Glycerolipid metabolism_Homo sapiens_hsa005611.38929808
33African trypanosomiasis_Homo sapiens_hsa051431.38436377
34Collecting duct acid secretion_Homo sapiens_hsa049661.36095141
35Measles_Homo sapiens_hsa051621.34064767
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.31662925
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30923098
38Leishmaniasis_Homo sapiens_hsa051401.30016275
39Cell cycle_Homo sapiens_hsa041101.29316199
40ECM-receptor interaction_Homo sapiens_hsa045121.29058929
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28451156
42Bladder cancer_Homo sapiens_hsa052191.26491430
43Osteoclast differentiation_Homo sapiens_hsa043801.21177491
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20818275
45Toxoplasmosis_Homo sapiens_hsa051451.18996936
46Herpes simplex infection_Homo sapiens_hsa051681.16355323
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14935847
48Proteasome_Homo sapiens_hsa030501.11940432
49Hepatitis B_Homo sapiens_hsa051611.08404631
50FoxO signaling pathway_Homo sapiens_hsa040681.07138945
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.05185891
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04361985
53TNF signaling pathway_Homo sapiens_hsa046681.02147688
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01722245
55MicroRNAs in cancer_Homo sapiens_hsa052061.00688310
56Insulin resistance_Homo sapiens_hsa049310.98051396
57Non-small cell lung cancer_Homo sapiens_hsa052230.94544313
58Influenza A_Homo sapiens_hsa051640.94197144
59RNA degradation_Homo sapiens_hsa030180.94060554
60Basal transcription factors_Homo sapiens_hsa030220.93214169
61Nicotine addiction_Homo sapiens_hsa050330.92200868
62Dorso-ventral axis formation_Homo sapiens_hsa043200.90999734
63Type II diabetes mellitus_Homo sapiens_hsa049300.87274352
64Mineral absorption_Homo sapiens_hsa049780.87219001
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86645559
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86314529
67Rheumatoid arthritis_Homo sapiens_hsa053230.86295881
68Tuberculosis_Homo sapiens_hsa051520.85428269
69Caffeine metabolism_Homo sapiens_hsa002320.85076560
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83515395
71Propanoate metabolism_Homo sapiens_hsa006400.83130502
72RNA polymerase_Homo sapiens_hsa030200.82892852
73Melanoma_Homo sapiens_hsa052180.82849722
74Phagosome_Homo sapiens_hsa041450.82305760
75Prostate cancer_Homo sapiens_hsa052150.81587425
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80799409
77AMPK signaling pathway_Homo sapiens_hsa041520.80034865
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77833945
79Chemokine signaling pathway_Homo sapiens_hsa040620.74757985
80Glioma_Homo sapiens_hsa052140.72195807
81Morphine addiction_Homo sapiens_hsa050320.71592390
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70265374
83Prolactin signaling pathway_Homo sapiens_hsa049170.70127219
84Purine metabolism_Homo sapiens_hsa002300.69251169
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67869817
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67174474
87Type I diabetes mellitus_Homo sapiens_hsa049400.67036494
88Focal adhesion_Homo sapiens_hsa045100.66678505
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65620700
90Legionellosis_Homo sapiens_hsa051340.65215868
91Hepatitis C_Homo sapiens_hsa051600.64787010
92HTLV-I infection_Homo sapiens_hsa051660.64743986
93Epstein-Barr virus infection_Homo sapiens_hsa051690.63920530
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.61895693
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61343063
96Amoebiasis_Homo sapiens_hsa051460.61038270
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60501898
98Fanconi anemia pathway_Homo sapiens_hsa034600.59946238
99Lysine degradation_Homo sapiens_hsa003100.59804803
100B cell receptor signaling pathway_Homo sapiens_hsa046620.59765997
101Sphingolipid metabolism_Homo sapiens_hsa006000.58890705
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58684918
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58363871
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57482386
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57471157
106Acute myeloid leukemia_Homo sapiens_hsa052210.57240444
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.57166271
108Platelet activation_Homo sapiens_hsa046110.56772339
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51818046
110Pertussis_Homo sapiens_hsa051330.49785025
111Staphylococcus aureus infection_Homo sapiens_hsa051500.49509549
112Shigellosis_Homo sapiens_hsa051310.48409872
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.47745789
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46264027
115Proteoglycans in cancer_Homo sapiens_hsa052050.46208304
116Adherens junction_Homo sapiens_hsa045200.44708856
117Other glycan degradation_Homo sapiens_hsa005110.44650149
118T cell receptor signaling pathway_Homo sapiens_hsa046600.43458005
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42594313
120Primary immunodeficiency_Homo sapiens_hsa053400.41172988
121Regulation of autophagy_Homo sapiens_hsa041400.38057774
122Arachidonic acid metabolism_Homo sapiens_hsa005900.37031856
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35411889
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34531017
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.34361585
126HIF-1 signaling pathway_Homo sapiens_hsa040660.34017490
127Pyrimidine metabolism_Homo sapiens_hsa002400.33209706
128Circadian rhythm_Homo sapiens_hsa047100.32942637
129Antigen processing and presentation_Homo sapiens_hsa046120.32820199
130Protein digestion and absorption_Homo sapiens_hsa049740.31675319
131Pathways in cancer_Homo sapiens_hsa052000.31355297
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30239190
133One carbon pool by folate_Homo sapiens_hsa006700.29475636
134Dilated cardiomyopathy_Homo sapiens_hsa054140.29246036
135Nucleotide excision repair_Homo sapiens_hsa034200.28947842
136Insulin signaling pathway_Homo sapiens_hsa049100.28298094
137Serotonergic synapse_Homo sapiens_hsa047260.28283864
138Base excision repair_Homo sapiens_hsa034100.28265744
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.28045997
140Salmonella infection_Homo sapiens_hsa051320.27815846
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27209714
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26359573
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25808661
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25146227
145Endocytosis_Homo sapiens_hsa041440.23408381
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.23362781
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20980631
148Viral myocarditis_Homo sapiens_hsa054160.20698403

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