MARCH6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.96965501
2presynaptic membrane assembly (GO:0097105)4.84879739
3synaptic vesicle maturation (GO:0016188)4.83922110
4locomotory exploration behavior (GO:0035641)4.75111297
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43252753
6presynaptic membrane organization (GO:0097090)4.34585025
7vocalization behavior (GO:0071625)4.31078422
8layer formation in cerebral cortex (GO:0021819)4.22235029
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.20480344
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.07991181
11glutamate secretion (GO:0014047)4.02112180
12regulation of glutamate receptor signaling pathway (GO:1900449)3.93232640
13synaptic vesicle exocytosis (GO:0016079)3.91083229
14exploration behavior (GO:0035640)3.79698013
15regulation of synaptic vesicle exocytosis (GO:2000300)3.75835511
16limb bud formation (GO:0060174)3.64790990
17neural tube formation (GO:0001841)3.62835855
18neurotransmitter secretion (GO:0007269)3.61505549
19neuron cell-cell adhesion (GO:0007158)3.58973953
20proline transport (GO:0015824)3.54026035
21protein localization to synapse (GO:0035418)3.51067615
22dendritic spine morphogenesis (GO:0060997)3.49059215
23gamma-aminobutyric acid transport (GO:0015812)3.48072011
24activation of protein kinase A activity (GO:0034199)3.47829757
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46057232
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.45459959
27neurotransmitter-gated ion channel clustering (GO:0072578)3.43277626
28retinal ganglion cell axon guidance (GO:0031290)3.41848821
29DNA double-strand break processing (GO:0000729)3.40259223
30sodium ion export (GO:0071436)3.39200416
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.38737826
32regulation of neuronal synaptic plasticity (GO:0048168)3.37818458
33regulation of synaptic vesicle transport (GO:1902803)3.35188776
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34954544
35regulation of synapse structural plasticity (GO:0051823)3.34845037
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31417020
37pyrimidine nucleobase catabolic process (GO:0006208)3.28689919
38dendrite morphogenesis (GO:0048813)3.26521291
39cellular potassium ion homeostasis (GO:0030007)3.26339654
40protein localization to cilium (GO:0061512)3.24287862
41response to pheromone (GO:0019236)3.22436357
42nucleobase catabolic process (GO:0046113)3.21619941
43glial cell proliferation (GO:0014009)3.19510476
44neuron recognition (GO:0008038)3.14772815
45cell communication by electrical coupling (GO:0010644)3.12367981
46glycosphingolipid biosynthetic process (GO:0006688)3.10438303
47axonal fasciculation (GO:0007413)3.08636677
48glutamate receptor signaling pathway (GO:0007215)3.05766706
49startle response (GO:0001964)3.03025680
50cornea development in camera-type eye (GO:0061303)3.01903694
51olfactory bulb development (GO:0021772)3.00896060
52positive regulation of mitochondrial fission (GO:0090141)2.97788864
53cerebral cortex radially oriented cell migration (GO:0021799)2.96776158
54keratinocyte development (GO:0003334)2.95653277
55neuronal action potential propagation (GO:0019227)2.94970621
56synaptic transmission, glutamatergic (GO:0035249)2.94033693
57nonmotile primary cilium assembly (GO:0035058)2.88307054
58protein polyglutamylation (GO:0018095)2.88110366
59positive regulation of synapse maturation (GO:0090129)2.87773702
60regulation of dendritic spine morphogenesis (GO:0061001)2.87627909
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86446707
62regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84777743
63regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.84740476
64neuron-neuron synaptic transmission (GO:0007270)2.84666895
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.82510658
66neurotransmitter transport (GO:0006836)2.82265823
67cerebellar Purkinje cell differentiation (GO:0021702)2.81796066
68central nervous system neuron axonogenesis (GO:0021955)2.81606305
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81327616
70establishment of mitochondrion localization (GO:0051654)2.80129289
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79708347
72long-term memory (GO:0007616)2.79070289
73neuromuscular process controlling balance (GO:0050885)2.75893876
74somite development (GO:0061053)2.75151354
75inositol phosphate catabolic process (GO:0071545)2.75046129
76regulation of ARF protein signal transduction (GO:0032012)2.74976510
77sympathetic nervous system development (GO:0048485)2.74825614
78regulation of postsynaptic membrane potential (GO:0060078)2.73852099
79cilium morphogenesis (GO:0060271)2.73499561
80cilium organization (GO:0044782)2.72699254
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72541249
82cilium assembly (GO:0042384)2.70914044
83calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70737447
84spinal cord development (GO:0021510)2.69755962
85innervation (GO:0060384)2.69386811
86positive regulation of membrane potential (GO:0045838)2.68840656
87vesicle transport along microtubule (GO:0047496)2.68098503
88dicarboxylic acid biosynthetic process (GO:0043650)2.67982073
89retinal cone cell development (GO:0046549)2.66989260
90positive regulation of oligodendrocyte differentiation (GO:0048714)2.66591256
91regulation of neurotransmitter levels (GO:0001505)2.66469952
92protein K11-linked deubiquitination (GO:0035871)2.65910735
93cell communication involved in cardiac conduction (GO:0086065)2.65872081
94suckling behavior (GO:0001967)2.65059181
95alanine transport (GO:0032328)2.64835680
96intraciliary transport (GO:0042073)2.64271486
97establishment of nucleus localization (GO:0040023)2.63563092
98response to histamine (GO:0034776)2.62499646
99behavioral response to nicotine (GO:0035095)2.62167676
100regulation of synaptic plasticity (GO:0048167)2.61788024
101histone H2A acetylation (GO:0043968)2.61100026
102dentate gyrus development (GO:0021542)2.61094272
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59961314
104negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59096646
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58914176
106mating behavior (GO:0007617)2.57977607
107regulation of telomere maintenance (GO:0032204)2.57713596
108clathrin coat assembly (GO:0048268)2.56746123
109regulation of collateral sprouting (GO:0048670)2.56617854
110hindbrain development (GO:0030902)2.56417357
111prepulse inhibition (GO:0060134)2.55488588
112regulation of feeding behavior (GO:0060259)2.54911174
113auditory behavior (GO:0031223)2.54883070
114negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54813987
115cellular sodium ion homeostasis (GO:0006883)2.54111885
116organelle transport along microtubule (GO:0072384)2.54033850
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53465755
118regulation of synaptic transmission, glutamatergic (GO:0051966)2.52365650
119G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.51215983
120synaptic vesicle endocytosis (GO:0048488)2.50950436
121neuronal action potential (GO:0019228)2.50754149
122head development (GO:0060322)2.50265258
123cerebellar granule cell differentiation (GO:0021707)2.49868148
124transmission of nerve impulse (GO:0019226)2.49346998
125nerve growth factor signaling pathway (GO:0038180)2.48509608
126hippocampus development (GO:0021766)2.48063700
127positive regulation of synapse assembly (GO:0051965)2.47647189
128reflex (GO:0060004)2.47428307
129cell migration in hindbrain (GO:0021535)2.47225743
130cerebellar Purkinje cell layer development (GO:0021680)2.46875111
131long-term synaptic potentiation (GO:0060291)2.46645586
132behavioral fear response (GO:0001662)2.46486094
133behavioral defense response (GO:0002209)2.46486094
134membrane hyperpolarization (GO:0060081)2.46144471
135mechanosensory behavior (GO:0007638)2.44684527
136regulation of dendritic spine development (GO:0060998)2.44660524
137fucose catabolic process (GO:0019317)2.44551518
138L-fucose metabolic process (GO:0042354)2.44551518
139L-fucose catabolic process (GO:0042355)2.44551518
140intraspecies interaction between organisms (GO:0051703)2.44245348
141social behavior (GO:0035176)2.44245348
142membrane depolarization during action potential (GO:0086010)2.43980532
143central nervous system projection neuron axonogenesis (GO:0021952)2.43824240
144positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.43183705
145inner ear receptor stereocilium organization (GO:0060122)2.42891123
146regulation of clathrin-mediated endocytosis (GO:2000369)2.42587586
147synapse organization (GO:0050808)2.42391889
148positive regulation of amino acid transport (GO:0051957)2.41946830
149gamma-aminobutyric acid signaling pathway (GO:0007214)2.40160849
150negative regulation of dendrite development (GO:2000171)2.40098597
151kidney morphogenesis (GO:0060993)2.40015554
152negative regulation of sodium ion transport (GO:0010766)2.39343739
153positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39235101
154DNA integration (GO:0015074)2.39229177
155behavioral response to ethanol (GO:0048149)2.38997472
156protein targeting to Golgi (GO:0000042)2.38819228
157C4-dicarboxylate transport (GO:0015740)2.38207445
158axoneme assembly (GO:0035082)2.37732451
159prostate gland growth (GO:0060736)2.37688195
160membrane depolarization (GO:0051899)2.37436652
161regulation of cilium movement (GO:0003352)2.37338617
162regulation of neurotransmitter uptake (GO:0051580)2.37318993
163synapse assembly (GO:0007416)2.37317250
164postsynaptic membrane organization (GO:0001941)2.36970960
165fear response (GO:0042596)2.36634680
166negative regulation of translation, ncRNA-mediated (GO:0040033)2.36401674
167regulation of translation, ncRNA-mediated (GO:0045974)2.36401674
168negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.36401674
169positive regulation of dendritic spine morphogenesis (GO:0061003)2.35789086
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35240529
171water-soluble vitamin biosynthetic process (GO:0042364)2.34963407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.69471415
2GBX2_23144817_ChIP-Seq_PC3_Human2.83518935
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.53603474
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53502604
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51287759
6FUS_26573619_Chip-Seq_HEK293_Human2.43772415
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35026735
8VDR_22108803_ChIP-Seq_LS180_Human2.31271180
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23919926
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.20667766
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19657825
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19657825
13DROSHA_22980978_ChIP-Seq_HELA_Human2.19531281
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19258967
15REST_21632747_ChIP-Seq_MESCs_Mouse2.19022583
16EWS_26573619_Chip-Seq_HEK293_Human2.15100819
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14961310
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09210673
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07616361
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05543574
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02246418
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01340030
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00564862
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99016185
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.92000183
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85230532
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.83757208
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80956303
29AR_21572438_ChIP-Seq_LNCaP_Human1.78985024
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.78172987
31ER_23166858_ChIP-Seq_MCF-7_Human1.76976115
32ZNF274_21170338_ChIP-Seq_K562_Hela1.76404089
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.75588156
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.74089878
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72762695
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.72646492
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.72007016
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70011138
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.68327452
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67739786
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66215822
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65271131
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62512460
44CBP_20019798_ChIP-Seq_JUKART_Human1.62412679
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62412679
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59828937
47RNF2_27304074_Chip-Seq_NSC_Mouse1.58952298
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57994840
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56657499
50SMAD4_21799915_ChIP-Seq_A2780_Human1.56152119
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54942377
52TAF15_26573619_Chip-Seq_HEK293_Human1.47154007
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46534185
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45880159
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45668643
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.44320222
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43255134
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41036676
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40140443
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.36476793
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35640845
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34517380
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33705681
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.33414226
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33350279
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32898717
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30097541
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28533557
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27277140
70RUNX2_22187159_ChIP-Seq_PCA_Human1.25857476
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25202614
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.25028805
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.24655018
74AR_19668381_ChIP-Seq_PC3_Human1.24615256
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24140972
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23754968
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22681549
78STAT3_23295773_ChIP-Seq_U87_Human1.21197903
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20898538
80IGF1R_20145208_ChIP-Seq_DFB_Human1.20836147
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20777892
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.20354744
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.20129214
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19817468
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19817468
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.19414862
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19279049
88P300_19829295_ChIP-Seq_ESCs_Human1.18488941
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.18446413
90P53_22387025_ChIP-Seq_ESCs_Mouse1.17955655
91AR_25329375_ChIP-Seq_VCAP_Human1.17884146
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17365481
93BCAT_22108803_ChIP-Seq_LS180_Human1.16991496
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.16320726
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.15649667
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14846219
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14715604
98JUN_21703547_ChIP-Seq_K562_Human1.14034138
99AHR_22903824_ChIP-Seq_MCF-7_Human1.12952318
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12747278
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.12159133
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11158084
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10725104
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.10487790
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10387182
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.10009900
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08948318
108KDM2B_26808549_Chip-Seq_K562_Human1.08573812
109TP53_16413492_ChIP-PET_HCT116_Human1.08398090
110IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08392263
111TCF4_22108803_ChIP-Seq_LS180_Human1.08155701
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08147049
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07750597
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07208969
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06984420
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06748955
117RXR_22108803_ChIP-Seq_LS180_Human1.06193000
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05979401
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05384038
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05100664
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04961988
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04765117
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.04435172
124SMAD4_21741376_ChIP-Seq_HESCs_Human1.04314598
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03861563
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03569460
127ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03449317
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.03370490
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03136551
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02843891
131SOX2_19829295_ChIP-Seq_ESCs_Human1.02692439
132NANOG_19829295_ChIP-Seq_ESCs_Human1.02692439
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01853782
134TCF4_23295773_ChIP-Seq_U87_Human1.01120261
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.01061718
136EP300_21415370_ChIP-Seq_HL-1_Mouse1.00656433
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00613964
138IRF1_19129219_ChIP-ChIP_H3396_Human1.00131321
139TP53_22573176_ChIP-Seq_HFKS_Human1.00053036
140TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99791801
141RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99505020
142SOX9_26525672_Chip-Seq_HEART_Mouse0.99194581
143FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98979249
144SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98967518
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.98683596
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.98213412
147SMAD_19615063_ChIP-ChIP_OVARY_Human0.98056498
148CRX_20693478_ChIP-Seq_RETINA_Mouse0.97880692
149EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97409434
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.96919454
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96264319
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95370483
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94092983
154P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93684464
155CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91645943
156PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91614360
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91230490
158SMAD3_21741376_ChIP-Seq_HESCs_Human0.90145906
159POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89870280
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.88773702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.62115530
2MP0003635_abnormal_synaptic_transmissio3.56541839
3MP0004270_analgesia3.45505386
4MP0003880_abnormal_central_pattern3.40307315
5MP0002102_abnormal_ear_morphology3.08740492
6MP0002063_abnormal_learning/memory/cond2.88144194
7MP0009745_abnormal_behavioral_response2.74485817
8MP0009780_abnormal_chondrocyte_physiolo2.66472537
9MP0008877_abnormal_DNA_methylation2.51967223
10MP0002064_seizures2.45268295
11MP0002139_abnormal_hepatobiliary_system2.40376684
12MP0005360_urolithiasis2.39569082
13MP0002572_abnormal_emotion/affect_behav2.28874270
14MP0009046_muscle_twitch2.23034335
15MP0002909_abnormal_adrenal_gland2.22808756
16MP0001968_abnormal_touch/_nociception2.22591363
17MP0003329_amyloid_beta_deposits2.18162285
18MP0005423_abnormal_somatic_nervous2.17437852
19MP0000569_abnormal_digit_pigmentation2.14304105
20MP0002734_abnormal_mechanical_nocicepti2.08354002
21MP0002837_dystrophic_cardiac_calcinosis2.00932811
22MP0002822_catalepsy2.00211640
23MP0006072_abnormal_retinal_apoptosis1.94924256
24MP0008789_abnormal_olfactory_epithelium1.93192664
25MP0006292_abnormal_olfactory_placode1.91670627
26MP0001529_abnormal_vocalization1.91013107
27MP0001486_abnormal_startle_reflex1.89594429
28MP0005499_abnormal_olfactory_system1.89348629
29MP0005394_taste/olfaction_phenotype1.89348629
30MP0005085_abnormal_gallbladder_physiolo1.86766760
31MP0001440_abnormal_grooming_behavior1.83483238
32MP0002272_abnormal_nervous_system1.78715243
33MP0003121_genomic_imprinting1.76038849
34MP0004130_abnormal_muscle_cell1.73252841
35MP0002751_abnormal_autonomic_nervous1.71039499
36MP0005253_abnormal_eye_physiology1.69977270
37MP0005551_abnormal_eye_electrophysiolog1.69223314
38MP0001501_abnormal_sleep_pattern1.68454851
39MP0000778_abnormal_nervous_system1.66049500
40MP0002733_abnormal_thermal_nociception1.65162677
41MP0004924_abnormal_behavior1.62759585
42MP0005386_behavior/neurological_phenoty1.62759585
43MP0004858_abnormal_nervous_system1.62001514
44MP0000631_abnormal_neuroendocrine_gland1.61857326
45MP0005365_abnormal_bile_salt1.57777963
46MP0004811_abnormal_neuron_physiology1.57444854
47MP0002735_abnormal_chemical_nociception1.55194111
48MP0008875_abnormal_xenobiotic_pharmacok1.55073636
49MP0002638_abnormal_pupillary_reflex1.51966106
50MP0008961_abnormal_basal_metabolism1.51912704
51MP0002067_abnormal_sensory_capabilities1.51681182
52MP0002736_abnormal_nociception_after1.48155520
53MP0008995_early_reproductive_senescence1.47914325
54MP0000604_amyloidosis1.47856817
55MP0002234_abnormal_pharynx_morphology1.47735173
56MP0004885_abnormal_endolymph1.47539263
57MP0002184_abnormal_innervation1.46739213
58MP0005187_abnormal_penis_morphology1.46403285
59MP0002557_abnormal_social/conspecific_i1.44695793
60MP0008569_lethality_at_weaning1.44272468
61MP0001188_hyperpigmentation1.43255781
62MP0002938_white_spotting1.41955144
63MP0000751_myopathy1.39663873
64MP0001970_abnormal_pain_threshold1.37392432
65MP0010329_abnormal_lipoprotein_level1.37339105
66MP0005646_abnormal_pituitary_gland1.35579738
67MP0010234_abnormal_vibrissa_follicle1.34141459
68MP0000955_abnormal_spinal_cord1.33477615
69MP0003633_abnormal_nervous_system1.30317186
70MP0003122_maternal_imprinting1.28441966
71MP0003252_abnormal_bile_duct1.27211610
72MP0006276_abnormal_autonomic_nervous1.26577823
73MP0000516_abnormal_urinary_system1.26377635
74MP0005367_renal/urinary_system_phenotyp1.26377635
75MP0000427_abnormal_hair_cycle1.25995070
76MP0004142_abnormal_muscle_tone1.24475842
77MP0005248_abnormal_Harderian_gland1.21622463
78MP0008058_abnormal_DNA_repair1.20405530
79MP0003938_abnormal_ear_development1.19731337
80MP0003879_abnormal_hair_cell1.18269810
81MP0000647_abnormal_sebaceous_gland1.18053797
82MP0004145_abnormal_muscle_electrophysio1.17936403
83MP0005535_abnormal_body_temperature1.17472132
84MP0002066_abnormal_motor_capabilities/c1.16739197
85MP0003283_abnormal_digestive_organ1.16182019
86MP0000049_abnormal_middle_ear1.13941481
87MP0001502_abnormal_circadian_rhythm1.12864852
88MP0004215_abnormal_myocardial_fiber1.11652162
89MP0002882_abnormal_neuron_morphology1.05368094
90MP0000013_abnormal_adipose_tissue1.05156063
91MP0004133_heterotaxia1.04551602
92MP0004147_increased_porphyrin_level1.04287010
93MP0002752_abnormal_somatic_nervous1.04118111
94MP0003937_abnormal_limbs/digits/tail_de1.04045634
95MP0000372_irregular_coat_pigmentation1.03721234
96MP0003631_nervous_system_phenotype1.03341878
97MP0005645_abnormal_hypothalamus_physiol1.01386604
98MP0004043_abnormal_pH_regulation1.00660673
99MP0004233_abnormal_muscle_weight1.00188539
100MP0004085_abnormal_heartbeat0.99536762
101MP0002233_abnormal_nose_morphology0.98685881
102MP0002069_abnormal_eating/drinking_beha0.97493732
103MP0000566_synostosis0.96870950
104MP0000383_abnormal_hair_follicle0.94369693
105MP0003787_abnormal_imprinting0.94167689
106MP0003868_abnormal_feces_composition0.94089179
107MP0003890_abnormal_embryonic-extraembry0.93700787
108MP0005171_absent_coat_pigmentation0.93026078
109MP0002152_abnormal_brain_morphology0.92438336
110MP0003690_abnormal_glial_cell0.91034207
111MP0001986_abnormal_taste_sensitivity0.90128662
112MP0002078_abnormal_glucose_homeostasis0.89732172
113MP0003119_abnormal_digestive_system0.89525957
114MP0008874_decreased_physiological_sensi0.88704564
115MP0005195_abnormal_posterior_eye0.88387317
116MP0001485_abnormal_pinna_reflex0.88074024
117MP0002653_abnormal_ependyma_morphology0.87748728
118MP0001984_abnormal_olfaction0.85901483
119MP0002090_abnormal_vision0.85477386
120MP0002118_abnormal_lipid_homeostasis0.85433994
121MP0000026_abnormal_inner_ear0.83524723
122MP0003172_abnormal_lysosome_physiology0.83045372
123MP0003861_abnormal_nervous_system0.83012259
124MP0003755_abnormal_palate_morphology0.81902555
125MP0002928_abnormal_bile_duct0.81589776
126MP0003646_muscle_fatigue0.81522848
127MP0001177_atelectasis0.80772430
128MP0004484_altered_response_of0.80495239
129MP0000747_muscle_weakness0.80249347
130MP0003075_altered_response_to0.79780499
131MP0003567_abnormal_fetal_cardiomyocyte0.79343784
132MP0005391_vision/eye_phenotype0.78699426
133MP0003195_calcinosis0.78317631
134MP0004742_abnormal_vestibular_system0.78317545
135MP0004036_abnormal_muscle_relaxation0.77975885
136MP0002876_abnormal_thyroid_physiology0.74082198
137MP0003632_abnormal_nervous_system0.73354015
138MP0002229_neurodegeneration0.72726625
139MP0001299_abnormal_eye_distance/0.72225970
140MP0005620_abnormal_muscle_contractility0.71422431
141MP0005448_abnormal_energy_balance0.71046890
142MP0005332_abnormal_amino_acid0.68883843
143MP0008872_abnormal_physiological_respon0.68425532
144MP0003137_abnormal_impulse_conducting0.67379370
145MP0001666_abnormal_nutrient_absorption0.66841193
146MP0005167_abnormal_blood-brain_barrier0.64038793
147MP0003953_abnormal_hormone_level0.63938860
148MP0003634_abnormal_glial_cell0.61196217
149MP0002269_muscular_atrophy0.60667941

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.19416460
2Focal seizures (HP:0007359)4.30080147
3Visual hallucinations (HP:0002367)4.26917837
4Myokymia (HP:0002411)4.21541761
5Abnormality of the labia minora (HP:0012880)3.86455470
6Pancreatic cysts (HP:0001737)3.38580541
7Absence seizures (HP:0002121)3.36739519
8Pancreatic fibrosis (HP:0100732)3.29755034
9Action tremor (HP:0002345)3.27622500
10True hermaphroditism (HP:0010459)3.23499355
11Epileptic encephalopathy (HP:0200134)3.19795402
12Atonic seizures (HP:0010819)3.16760154
13Generalized tonic-clonic seizures (HP:0002069)3.16016543
14Papilledema (HP:0001085)3.10246385
15Medial flaring of the eyebrow (HP:0010747)3.06958259
16Abnormal social behavior (HP:0012433)3.04699842
17Impaired social interactions (HP:0000735)3.04699842
18Cystic liver disease (HP:0006706)2.97786345
19Gait imbalance (HP:0002141)2.97280161
20Poor eye contact (HP:0000817)2.96142256
21Impaired vibration sensation in the lower limbs (HP:0002166)2.94952401
22Nephronophthisis (HP:0000090)2.92435287
23Hyperventilation (HP:0002883)2.91405485
24Dialeptic seizures (HP:0011146)2.90160187
25Insidious onset (HP:0003587)2.87650603
26Termporal pattern (HP:0011008)2.87650603
27Progressive cerebellar ataxia (HP:0002073)2.86492134
28Excessive salivation (HP:0003781)2.86194816
29Drooling (HP:0002307)2.86194816
30Molar tooth sign on MRI (HP:0002419)2.83964470
31Abnormality of midbrain morphology (HP:0002418)2.83964470
32Urinary bladder sphincter dysfunction (HP:0002839)2.83238607
33Cerebral inclusion bodies (HP:0100314)2.83154318
34Intestinal atresia (HP:0011100)2.79314243
35Supranuclear gaze palsy (HP:0000605)2.78741899
36Absent speech (HP:0001344)2.77501847
37Congenital primary aphakia (HP:0007707)2.77307153
38Postural instability (HP:0002172)2.75891147
39Broad-based gait (HP:0002136)2.72687116
40Dysmetric saccades (HP:0000641)2.69796165
41Depression (HP:0000716)2.69665944
42Nephrogenic diabetes insipidus (HP:0009806)2.67610041
43Deep venous thrombosis (HP:0002625)2.63568393
44Febrile seizures (HP:0002373)2.60859346
45Dysdiadochokinesis (HP:0002075)2.59681069
46Abnormality of the lower motor neuron (HP:0002366)2.57968315
47Genital tract atresia (HP:0001827)2.55158398
48Genetic anticipation (HP:0003743)2.53315853
49Agitation (HP:0000713)2.52701276
50Anxiety (HP:0000739)2.52698914
51Truncal ataxia (HP:0002078)2.51598919
52Epileptiform EEG discharges (HP:0011182)2.50306318
53Neurofibrillary tangles (HP:0002185)2.47690616
54EEG with generalized epileptiform discharges (HP:0011198)2.47687449
55Mutism (HP:0002300)2.46653359
56Abnormality of the renal medulla (HP:0100957)2.46263455
57Urinary urgency (HP:0000012)2.45464687
58Abnormal eating behavior (HP:0100738)2.44411957
59Ankle clonus (HP:0011448)2.44052193
60Hypsarrhythmia (HP:0002521)2.40608413
61Vaginal atresia (HP:0000148)2.38900897
62Limb dystonia (HP:0002451)2.35944150
63Status epilepticus (HP:0002133)2.35116168
64Macroorchidism (HP:0000053)2.34298648
65Ketoacidosis (HP:0001993)2.33965647
66Lissencephaly (HP:0001339)2.33751888
67Abnormality of the corticospinal tract (HP:0002492)2.31719098
68Torticollis (HP:0000473)2.28964819
69Hypothermia (HP:0002045)2.27657829
70Methylmalonic acidemia (HP:0002912)2.26767409
71Intention tremor (HP:0002080)2.25347782
72Chronic hepatic failure (HP:0100626)2.25343629
73Pheochromocytoma (HP:0002666)2.24425647
74Tented upper lip vermilion (HP:0010804)2.21351644
75Exercise-induced myalgia (HP:0003738)2.20180628
76Impaired smooth pursuit (HP:0007772)2.19357854
77Amblyopia (HP:0000646)2.19051643
78Amyotrophic lateral sclerosis (HP:0007354)2.18753378
79Gaze-evoked nystagmus (HP:0000640)2.18074240
80Progressive inability to walk (HP:0002505)2.16753211
81Dysmetria (HP:0001310)2.15769242
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.15643923
83Inability to walk (HP:0002540)2.15480538
84Retinal dysplasia (HP:0007973)2.13628902
85Ketosis (HP:0001946)2.13510827
86Postaxial hand polydactyly (HP:0001162)2.12996280
87Specific learning disability (HP:0001328)2.11194789
88Abnormality of the astrocytes (HP:0100707)2.09952460
89Astrocytoma (HP:0009592)2.09952460
90Abnormality of the renal cortex (HP:0011035)2.08733235
91Spastic gait (HP:0002064)2.08404658
92Postaxial foot polydactyly (HP:0001830)2.03154059
93Hepatoblastoma (HP:0002884)2.02910811
94Impaired vibratory sensation (HP:0002495)2.01972680
95Bradykinesia (HP:0002067)2.01788217
96Pachygyria (HP:0001302)2.00738819
97Hemiplegia (HP:0002301)2.00548301
98Abnormality of the metopic suture (HP:0005556)1.99861435
99Focal dystonia (HP:0004373)1.99224962
100Labial hypoplasia (HP:0000066)1.98382543
101Poor coordination (HP:0002370)1.98050703
102Aqueductal stenosis (HP:0002410)1.97955915
103Occipital encephalocele (HP:0002085)1.97919500
104Patellar aplasia (HP:0006443)1.97836358
105Scanning speech (HP:0002168)1.97621095
106Epidermoid cyst (HP:0200040)1.97152415
107Gastrointestinal atresia (HP:0002589)1.96913665
108Optic nerve hypoplasia (HP:0000609)1.95934003
109Abnormality of ocular smooth pursuit (HP:0000617)1.94317418
110Stereotypic behavior (HP:0000733)1.93965273
111Blue irides (HP:0000635)1.92735673
112Dyskinesia (HP:0100660)1.91857429
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.91578634
114Type II lissencephaly (HP:0007260)1.90674587
115Exotropia (HP:0000577)1.89656929
116Bundle branch block (HP:0011710)1.89583546
117Pendular nystagmus (HP:0012043)1.89145219
118Inappropriate behavior (HP:0000719)1.89071720
119Craniofacial dystonia (HP:0012179)1.88627655
120Lower limb muscle weakness (HP:0007340)1.87007339
121Resting tremor (HP:0002322)1.86867231
122Polyphagia (HP:0002591)1.86751382
123Small hand (HP:0200055)1.86570424
124Aplasia/Hypoplasia of the patella (HP:0006498)1.86205691
125Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85722758
126Tubulointerstitial nephritis (HP:0001970)1.85304261
127Ankyloglossia (HP:0010296)1.84621037
128Xanthomatosis (HP:0000991)1.83897701
129Postural tremor (HP:0002174)1.83531354
130Narrow forehead (HP:0000341)1.82888653
131Megalencephaly (HP:0001355)1.82556909
132Oligodactyly (hands) (HP:0001180)1.82465704
133Insomnia (HP:0100785)1.81690647
134Gout (HP:0001997)1.81476343
135Renal hypoplasia (HP:0000089)1.81411824
136Generalized myoclonic seizures (HP:0002123)1.81410508
137Neoplasm of the adrenal cortex (HP:0100641)1.80770806
138Diplopia (HP:0000651)1.80564383
139Abnormality of binocular vision (HP:0011514)1.80564383
140Congenital stationary night blindness (HP:0007642)1.80366778
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.80259109
142Intrahepatic cholestasis (HP:0001406)1.80151524
143Renal cortical cysts (HP:0000803)1.79332900
144Ventricular fibrillation (HP:0001663)1.79046604
145Morphological abnormality of the pyramidal tract (HP:0002062)1.78813788
146Glioma (HP:0009733)1.78394783
147Ependymoma (HP:0002888)1.78087659
148Fetal akinesia sequence (HP:0001989)1.77774650
149Short tibia (HP:0005736)1.76880883
150Neuroendocrine neoplasm (HP:0100634)1.76808251
151Abolished electroretinogram (ERG) (HP:0000550)1.76726679
152Hypoplastic labia majora (HP:0000059)1.76275511
153Volvulus (HP:0002580)1.74284664
154Hemiparesis (HP:0001269)1.73854762
155Sudden death (HP:0001699)1.73189705
156Global brain atrophy (HP:0002283)1.72427698
157Sclerocornea (HP:0000647)1.72160686
158Lower limb asymmetry (HP:0100559)1.71613244
159Cutaneous finger syndactyly (HP:0010554)1.70688860
160Hypoplastic female external genitalia (HP:0012815)1.70532176
161Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69983699
162Skin nodule (HP:0200036)1.69753605
163Preaxial hand polydactyly (HP:0001177)1.69269708
164Clonus (HP:0002169)1.69104454
165Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68713096
166Furrowed tongue (HP:0000221)1.68305684
167Shawl scrotum (HP:0000049)1.68004696
168Neuronal loss in central nervous system (HP:0002529)1.67581955
169Generalized hypopigmentation of hair (HP:0011358)1.67558049
170Psychosis (HP:0000709)1.67358302
171Anencephaly (HP:0002323)1.65960024
172Degeneration of the lateral corticospinal tracts (HP:0002314)1.65133384
173Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.65133384
174Hyperglycinemia (HP:0002154)1.63995958
175Abnormality of the labia majora (HP:0012881)1.63872680
176Broad foot (HP:0001769)1.63509193
177Decreased testicular size (HP:0008734)1.63268408
178Oligodactyly (HP:0012165)1.62351970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.88618129
2NTRK33.81189124
3MAP3K93.47782757
4EPHA43.15083845
5MAP3K42.91637230
6BCR2.87277408
7TRIM282.83973613
8MAP4K22.57368963
9MINK12.37392034
10MAP2K42.33150423
11KSR22.16796456
12DAPK22.14618783
13NTRK22.06209159
14MAP2K71.98658888
15PRKD31.95729382
16PAK61.84904869
17NTRK11.82166553
18KSR11.80063840
19MAP3K21.76705459
20CAMKK11.75117835
21CSNK1G31.59606781
22CSNK1A1L1.56813932
23BMPR1B1.55025119
24PHKG21.53918779
25PHKG11.53918779
26SIK21.53718450
27CSNK1G11.49369472
28NUAK11.42131341
29EPHA31.36336534
30RET1.32651414
31LATS21.29955065
32CDK51.29793993
33AKT31.29267340
34DYRK21.25807642
35CAMK1G1.25486063
36MKNK21.20718079
37STK381.17332770
38RIPK41.17082155
39ACVR1B1.16868341
40MAP3K121.16255054
41BRSK21.14904435
42GRK11.14485851
43TRIB31.12120593
44STK38L1.11616398
45LMTK21.11290405
46MAPK131.09677901
47INSRR1.08765886
48CAMKK21.07766970
49SGK31.04957348
50TYRO31.04652300
51PNCK1.04609692
52PRKCH1.04345429
53OXSR11.04052126
54ADRBK21.03663150
55FGFR21.03497767
56DYRK31.01538445
57FRK0.99951857
58RIPK10.98581858
59PAK30.98521526
60DAPK10.97178326
61PKN20.96281539
62SCYL20.96171938
63SGK20.95331496
64SIK10.94006006
65SIK30.93903601
66PRKCE0.93294117
67SRPK10.91686375
68PRKCG0.90750836
69PLK20.90471404
70RPS6KA40.89538181
71CCNB10.88372550
72STK110.87202221
73SGK4940.86004965
74SGK2230.86004965
75STK390.85901549
76UHMK10.85588089
77MAP3K70.84721392
78CAMK2A0.82909660
79CSNK1G20.82395054
80ZAK0.81645803
81MKNK10.81511706
82GRK50.80955728
83TAOK10.80086576
84PDGFRA0.80057682
85SGK10.77615240
86PDK10.70011132
87MAP3K60.70003375
88PLK30.69511162
89ALK0.69179323
90EIF2AK30.67672610
91PDPK10.65347800
92CAMK1D0.65304411
93CAMK10.61999443
94TAOK30.61348433
95PLK40.60821160
96MARK20.60191751
97PRKCZ0.60061267
98NEK10.58099402
99RPS6KA30.57574246
100WEE10.57271910
101MAP3K10.57079964
102PRKAA10.55793343
103WNK40.54909191
104CSNK1D0.54702871
105WNK30.54396469
106CASK0.54011580
107MAPK120.53359509
108CDK140.53173594
109PKN10.53154610
110FES0.52863160
111CAMK2B0.52031789
112RPS6KA20.51955866
113CAMK40.51349004
114CDK180.51183960
115DMPK0.50946710
116PDK40.50802516
117PDK30.50802516
118CDK150.50720495
119ICK0.50695405
120ATM0.49370039
121YES10.48426839
122DYRK1A0.47160326
123FYN0.46776709
124FER0.45870797
125MAP2K10.45693997
126CSNK1A10.45273337
127RAF10.45094816
128CDC42BPA0.44441397
129PINK10.44385339
130MAPK100.44039566
131CDK190.43529300
132ERBB30.43498737
133LATS10.43333321
134FGFR30.42362183
135PTK2B0.42197058
136MAP3K130.41740835
137PTK20.41209024
138TNIK0.40018005
139BRD40.39996333
140ATR0.39482669
141PRKACB0.38657716
142PRKACA0.38238767
143CAMK2D0.37442071
144PLK10.33815053
145PRKDC0.33466160
146BCKDK0.30944850
147FLT30.29851797
148PRKG10.28657262
149CDK30.27416539
150EPHB20.26122404
151CSNK1E0.25858556
152ADRBK10.25710213
153PRKAA20.25016972

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.45307136
2Nitrogen metabolism_Homo sapiens_hsa009102.74681122
3Nicotine addiction_Homo sapiens_hsa050332.50495588
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32324926
5Phototransduction_Homo sapiens_hsa047442.14842316
6Long-term potentiation_Homo sapiens_hsa047202.12122138
7Synaptic vesicle cycle_Homo sapiens_hsa047212.05017106
8GABAergic synapse_Homo sapiens_hsa047272.03713731
9Circadian entrainment_Homo sapiens_hsa047132.02264634
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94882089
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89388668
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86769215
13Glutamatergic synapse_Homo sapiens_hsa047241.84148994
14Amphetamine addiction_Homo sapiens_hsa050311.82865108
15Non-homologous end-joining_Homo sapiens_hsa034501.80069528
16Fanconi anemia pathway_Homo sapiens_hsa034601.78974951
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76611946
18Steroid biosynthesis_Homo sapiens_hsa001001.75971714
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75328895
20Insulin secretion_Homo sapiens_hsa049111.74177420
21Olfactory transduction_Homo sapiens_hsa047401.73373532
22Morphine addiction_Homo sapiens_hsa050321.70677271
23Dopaminergic synapse_Homo sapiens_hsa047281.63294462
24Salivary secretion_Homo sapiens_hsa049701.62875135
25Arginine biosynthesis_Homo sapiens_hsa002201.59617901
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59429228
27Homologous recombination_Homo sapiens_hsa034401.57756410
28Renin secretion_Homo sapiens_hsa049241.52037788
29Gastric acid secretion_Homo sapiens_hsa049711.48627444
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47054174
31Cholinergic synapse_Homo sapiens_hsa047251.43390792
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43302213
33Bile secretion_Homo sapiens_hsa049761.40035947
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39947128
35Regulation of autophagy_Homo sapiens_hsa041401.39945749
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.39870075
37Basal transcription factors_Homo sapiens_hsa030221.36552061
38Type II diabetes mellitus_Homo sapiens_hsa049301.34903069
39Ether lipid metabolism_Homo sapiens_hsa005651.31426066
40Cocaine addiction_Homo sapiens_hsa050301.31122496
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30484041
42Butanoate metabolism_Homo sapiens_hsa006501.28276220
43Oxytocin signaling pathway_Homo sapiens_hsa049211.27285091
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24929540
45Long-term depression_Homo sapiens_hsa047301.21855553
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19698419
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15836776
48GnRH signaling pathway_Homo sapiens_hsa049121.15312363
49Selenocompound metabolism_Homo sapiens_hsa004501.14423436
50Linoleic acid metabolism_Homo sapiens_hsa005911.13409980
51Taste transduction_Homo sapiens_hsa047421.10944062
52Gap junction_Homo sapiens_hsa045401.09942320
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07820687
54Calcium signaling pathway_Homo sapiens_hsa040201.05126673
55Estrogen signaling pathway_Homo sapiens_hsa049151.04942368
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04660242
57Glioma_Homo sapiens_hsa052141.02398991
58Serotonergic synapse_Homo sapiens_hsa047261.01571802
59Glucagon signaling pathway_Homo sapiens_hsa049221.00543641
60cAMP signaling pathway_Homo sapiens_hsa040241.00270629
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99122432
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97167286
63Caffeine metabolism_Homo sapiens_hsa002320.96244517
64RNA degradation_Homo sapiens_hsa030180.95724284
65Dorso-ventral axis formation_Homo sapiens_hsa043200.94470919
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93149994
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92444931
68Fatty acid elongation_Homo sapiens_hsa000620.91248664
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88503672
70Hedgehog signaling pathway_Homo sapiens_hsa043400.87698263
71Axon guidance_Homo sapiens_hsa043600.86550022
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83431497
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83395355
74Fatty acid degradation_Homo sapiens_hsa000710.81077946
75Peroxisome_Homo sapiens_hsa041460.79787416
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79430033
77ErbB signaling pathway_Homo sapiens_hsa040120.77242641
78Thyroid hormone synthesis_Homo sapiens_hsa049180.76654619
79Melanogenesis_Homo sapiens_hsa049160.76552292
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76185484
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75749149
82Fatty acid metabolism_Homo sapiens_hsa012120.75531181
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74319703
84mTOR signaling pathway_Homo sapiens_hsa041500.74245569
85Dilated cardiomyopathy_Homo sapiens_hsa054140.73292151
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73070613
87Insulin signaling pathway_Homo sapiens_hsa049100.72927495
88Mismatch repair_Homo sapiens_hsa034300.71866931
89PPAR signaling pathway_Homo sapiens_hsa033200.70951265
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70710634
91Tryptophan metabolism_Homo sapiens_hsa003800.68611199
92Insulin resistance_Homo sapiens_hsa049310.66902428
93Pancreatic secretion_Homo sapiens_hsa049720.66566602
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66473174
95Propanoate metabolism_Homo sapiens_hsa006400.66384269
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.65203270
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61277035
98Cardiac muscle contraction_Homo sapiens_hsa042600.58998358
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58896456
100Endometrial cancer_Homo sapiens_hsa052130.58725288
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58137225
102Choline metabolism in cancer_Homo sapiens_hsa052310.57742190
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.56842056
104AMPK signaling pathway_Homo sapiens_hsa041520.56289561
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55857455
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55505727
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.54523709
108Collecting duct acid secretion_Homo sapiens_hsa049660.54449753
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.53311119
110beta-Alanine metabolism_Homo sapiens_hsa004100.52893116
111Prion diseases_Homo sapiens_hsa050200.51764079
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51584171
113Fatty acid biosynthesis_Homo sapiens_hsa000610.50777706
114Starch and sucrose metabolism_Homo sapiens_hsa005000.50464348
115mRNA surveillance pathway_Homo sapiens_hsa030150.50018911
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49508973
117Non-small cell lung cancer_Homo sapiens_hsa052230.49055801
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48450068
119Retinol metabolism_Homo sapiens_hsa008300.48165989
120Circadian rhythm_Homo sapiens_hsa047100.47890251
121VEGF signaling pathway_Homo sapiens_hsa043700.47014272
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.46720520
123Hippo signaling pathway_Homo sapiens_hsa043900.46221084
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45936640
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45917675
126Oxidative phosphorylation_Homo sapiens_hsa001900.45732386
127MAPK signaling pathway_Homo sapiens_hsa040100.44704333
128Oocyte meiosis_Homo sapiens_hsa041140.44573274
129Pyruvate metabolism_Homo sapiens_hsa006200.43816045
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.43080839
131Chemical carcinogenesis_Homo sapiens_hsa052040.42435454
132Complement and coagulation cascades_Homo sapiens_hsa046100.42269391
133Ovarian steroidogenesis_Homo sapiens_hsa049130.41338398
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.40368565
135Renal cell carcinoma_Homo sapiens_hsa052110.39515687
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39423761
137ABC transporters_Homo sapiens_hsa020100.38993414
138Vibrio cholerae infection_Homo sapiens_hsa051100.38103192
139Basal cell carcinoma_Homo sapiens_hsa052170.37017444
140Nucleotide excision repair_Homo sapiens_hsa034200.36703002
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36459376
142Lysine degradation_Homo sapiens_hsa003100.35485586
143Alcoholism_Homo sapiens_hsa050340.32380902
144Sulfur metabolism_Homo sapiens_hsa009200.31095923
145Wnt signaling pathway_Homo sapiens_hsa043100.29040829
146Parkinsons disease_Homo sapiens_hsa050120.28093932

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