MARCH7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of Golgi to plasma membrane protein transport (GO:0042996)4.47836578
2nuclear pore complex assembly (GO:0051292)4.37353641
3DNA double-strand break processing (GO:0000729)4.05746080
4mitotic G2 DNA damage checkpoint (GO:0007095)4.04445481
5mitotic sister chromatid cohesion (GO:0007064)3.99971559
6nuclear pore organization (GO:0006999)3.98740569
7negative regulation of DNA recombination (GO:0045910)3.71840853
8mitotic G2/M transition checkpoint (GO:0044818)3.71070669
9regulation of B cell receptor signaling pathway (GO:0050855)3.65080154
10regulation of DNA endoreduplication (GO:0032875)3.64394733
11protein targeting to Golgi (GO:0000042)3.51624070
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.50274705
13pore complex assembly (GO:0046931)3.49579236
14establishment of protein localization to Golgi (GO:0072600)3.42224882
15phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.39442622
16cytoplasmic mRNA processing body assembly (GO:0033962)3.34450538
17positive regulation of B cell differentiation (GO:0045579)3.33463510
18double-strand break repair via nonhomologous end joining (GO:0006303)3.32190455
19non-recombinational repair (GO:0000726)3.32190455
20protein prenylation (GO:0018342)3.26608922
21prenylation (GO:0097354)3.26608922
22negative regulation of histone methylation (GO:0031061)3.26588801
23regulation of histone H3-K9 methylation (GO:0051570)3.19563642
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16831038
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.14372856
26mitotic chromosome condensation (GO:0007076)3.13614231
27DNA ligation (GO:0006266)3.10489336
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.09168314
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09168314
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09168314
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07987221
32regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.04242560
33retrograde transport, vesicle recycling within Golgi (GO:0000301)3.03286268
34sister chromatid cohesion (GO:0007062)3.00153334
35histamine secretion (GO:0001821)2.97946585
36regulation of sister chromatid segregation (GO:0033045)2.96846004
37regulation of mitotic sister chromatid separation (GO:0010965)2.96846004
38regulation of mitotic sister chromatid segregation (GO:0033047)2.96846004
39microtubule anchoring (GO:0034453)2.95664772
40negative regulation of mitotic sister chromatid separation (GO:2000816)2.94286666
41negative regulation of sister chromatid segregation (GO:0033046)2.94286666
42negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94286666
43negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94286666
44negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94286666
45regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93636648
46mitotic spindle checkpoint (GO:0071174)2.93065385
47single strand break repair (GO:0000012)2.89156891
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87684290
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87250037
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87250037
51isotype switching (GO:0045190)2.87250037
52resolution of meiotic recombination intermediates (GO:0000712)2.86727038
53regulation of helicase activity (GO:0051095)2.86203944
54mitotic spindle assembly checkpoint (GO:0007094)2.82954778
55spindle assembly checkpoint (GO:0071173)2.81412968
56organelle disassembly (GO:1903008)2.78191644
57regulation of sister chromatid cohesion (GO:0007063)2.77491464
58spindle checkpoint (GO:0031577)2.77422407
59DNA topological change (GO:0006265)2.77153334
60regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.75572915
61negative regulation of chromosome segregation (GO:0051985)2.75211375
62somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74501236
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.74501236
64regulation of translation, ncRNA-mediated (GO:0045974)2.73391029
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73391029
66negative regulation of translation, ncRNA-mediated (GO:0040033)2.73391029
67centriole replication (GO:0007099)2.72688978
68positive regulation of gamma-delta T cell activation (GO:0046645)2.71462630
69ribonucleoprotein complex disassembly (GO:0032988)2.71075547
70histone mRNA metabolic process (GO:0008334)2.68690536
71regulation of chromatin silencing (GO:0031935)2.68303287
72histone H3-K36 demethylation (GO:0070544)2.68259223
73negative regulation of interleukin-17 production (GO:0032700)2.68210488
74monoubiquitinated protein deubiquitination (GO:0035520)2.67798339
75regulation of B cell differentiation (GO:0045577)2.67571099
76histone lysine demethylation (GO:0070076)2.66734559
77acrosome assembly (GO:0001675)2.65863117
78histone H3-K9 demethylation (GO:0033169)2.65545811
79negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.65119595
80mRNA modification (GO:0016556)2.63103234
81histone demethylation (GO:0016577)2.62881468
82response to interleukin-15 (GO:0070672)2.62849079
83regulation of RNA export from nucleus (GO:0046831)2.62557929
84spermatid nucleus differentiation (GO:0007289)2.61762718
85regulation of relaxation of muscle (GO:1901077)2.61471102
86regulation of meiosis I (GO:0060631)2.59915085
87interleukin-6-mediated signaling pathway (GO:0070102)2.58985163
88protein localization to Golgi apparatus (GO:0034067)2.58708505
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57813404
90ether lipid metabolic process (GO:0046485)2.57715210
91regulation of telomere maintenance via telomerase (GO:0032210)2.57179366
92regulation of establishment of cell polarity (GO:2000114)2.56055422
93hepatocyte apoptotic process (GO:0097284)2.55940078
94intraciliary transport (GO:0042073)2.53887219
95regulation of histone H3-K27 methylation (GO:0061085)2.53285843
96meiotic chromosome segregation (GO:0045132)2.52401201
97positive regulation of cell size (GO:0045793)2.52380685
98histone H3-K4 trimethylation (GO:0080182)2.52327419
99ribosome assembly (GO:0042255)2.51974234
100histone H2A monoubiquitination (GO:0035518)2.50202996
101early endosome to late endosome transport (GO:0045022)2.50163776
102protein K11-linked deubiquitination (GO:0035871)2.48941722
103replication fork processing (GO:0031297)2.48518220
104protein localization to kinetochore (GO:0034501)2.46676246
105B cell activation involved in immune response (GO:0002312)2.45038808
106B cell differentiation (GO:0030183)2.44512572
107nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.44483149
108regulation of centriole replication (GO:0046599)2.42787121
109embryonic process involved in female pregnancy (GO:0060136)2.42657908
110histone mRNA catabolic process (GO:0071044)2.42619328
111protein localization to chromosome, centromeric region (GO:0071459)2.41980637
112peptidyl-lysine trimethylation (GO:0018023)2.38582596
113definitive hemopoiesis (GO:0060216)2.38073565
114pre-miRNA processing (GO:0031054)2.35618211
115interkinetic nuclear migration (GO:0022027)2.34902845
116metaphase plate congression (GO:0051310)2.34791896
117interferon-gamma production (GO:0032609)2.34013591
118NIK/NF-kappaB signaling (GO:0038061)2.33927436
119replicative senescence (GO:0090399)2.33623357
120protein dealkylation (GO:0008214)2.33404807
121protein demethylation (GO:0006482)2.33404807
122attachment of spindle microtubules to kinetochore (GO:0008608)2.32958107
123regulation of fibroblast apoptotic process (GO:2000269)2.32489143
124regulation of interleukin-12 biosynthetic process (GO:0045075)2.30447236
125T-helper cell differentiation (GO:0042093)2.29130302
126CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.29130302
127positive T cell selection (GO:0043368)2.28822107
128mRNA splice site selection (GO:0006376)2.26895632
129response to X-ray (GO:0010165)2.26723080
130DNA geometric change (GO:0032392)2.26183791
131kinetochore organization (GO:0051383)2.25652072
132positive regulation of chromosome segregation (GO:0051984)2.24564631
133negative regulation of B cell proliferation (GO:0030889)2.23707078
134regulation of telomere maintenance (GO:0032204)2.23319263
135DNA duplex unwinding (GO:0032508)2.22898952
136dosage compensation (GO:0007549)2.20588161
137neural tube formation (GO:0001841)2.19961902
138determination of adult lifespan (GO:0008340)2.19393007
139protein localization to chromosome (GO:0034502)2.17731476
140telomere maintenance via telomerase (GO:0007004)2.17064218
141sister chromatid segregation (GO:0000819)2.15679536
142oocyte development (GO:0048599)2.14037036
143negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.12531250
144negative regulation of cell killing (GO:0031342)2.12531250
145establishment of chromosome localization (GO:0051303)2.12130866
146regulation of nucleobase-containing compound transport (GO:0032239)2.11644658
147regulation of histone methylation (GO:0031060)2.11356540
148negative regulation of histone modification (GO:0031057)2.10814831
149regulation of gamma-delta T cell differentiation (GO:0045586)2.10768134
150histone H3-K9 methylation (GO:0051567)2.09686147
151regulation of gamma-delta T cell activation (GO:0046643)2.09519187
152mitotic nuclear envelope disassembly (GO:0007077)2.08928858
153histone H3-K4 methylation (GO:0051568)2.08705550
154negative regulation of chromatin modification (GO:1903309)2.08574032
155I-kappaB phosphorylation (GO:0007252)2.07854881
156pyrimidine dimer repair (GO:0006290)2.07655249
157nuclear envelope disassembly (GO:0051081)2.07326509
158membrane disassembly (GO:0030397)2.07326509
159positive thymic T cell selection (GO:0045059)2.07085715
160mitotic metaphase plate congression (GO:0007080)2.06857658
161regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.05186431
162DNA replication-independent nucleosome assembly (GO:0006336)2.05154307
163DNA replication-independent nucleosome organization (GO:0034724)2.05154307
164regulation of mitotic spindle organization (GO:0060236)2.04281110
165positive regulation of mRNA catabolic process (GO:0061014)2.03380847
166chromatin remodeling at centromere (GO:0031055)2.03379549
167alpha-beta T cell differentiation (GO:0046632)2.03347696
168regulation of mitotic spindle checkpoint (GO:1903504)2.03200073
169regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.03200073
170CENP-A containing nucleosome assembly (GO:0034080)2.02704780
171intra-S DNA damage checkpoint (GO:0031573)2.02264124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.81214654
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.67128691
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.15248866
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.94502035
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.64207659
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.49654379
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15801236
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.00557728
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.81838018
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80785177
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60692802
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53940619
13IGF1R_20145208_ChIP-Seq_DFB_Human2.51219519
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.44954147
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44206243
16TAF15_26573619_Chip-Seq_HEK293_Human2.44180223
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16313384
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03983716
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03403731
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02824176
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02542944
22P300_19829295_ChIP-Seq_ESCs_Human1.94553857
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85720036
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80057763
25ELK1_19687146_ChIP-ChIP_HELA_Human1.77736162
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.73567127
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.72907649
28ZNF274_21170338_ChIP-Seq_K562_Hela1.72793928
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65952316
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65570462
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64757964
32GBX2_23144817_ChIP-Seq_PC3_Human1.62248442
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55526887
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55526887
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55106822
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54801552
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53632616
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53245360
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51999039
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.48358741
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.47479711
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.46185919
43MYB_26560356_Chip-Seq_TH2_Human1.45724600
44CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45563541
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.44586532
46EWS_26573619_Chip-Seq_HEK293_Human1.44416154
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44117111
48RUNX_20019798_ChIP-Seq_JUKART_Human1.43702949
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43113685
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43113685
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43113685
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42865575
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41096438
54VDR_22108803_ChIP-Seq_LS180_Human1.40889224
55ER_23166858_ChIP-Seq_MCF-7_Human1.39113041
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.38508410
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.38276798
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37422281
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35514937
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35502626
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33663137
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33436227
63TP53_16413492_ChIP-PET_HCT116_Human1.31685249
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31407456
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31238733
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31122829
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.30957354
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.30506457
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29375543
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27969737
71SALL4_22934838_ChIP-ChIP_CD34+_Human1.27955082
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27787877
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27787877
74MYC_22102868_ChIP-Seq_BL_Human1.27337737
75MYB_26560356_Chip-Seq_TH1_Human1.26956881
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26384100
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.26287678
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26071601
79SMAD4_21799915_ChIP-Seq_A2780_Human1.25802040
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25108875
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24891571
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23775326
83P53_22387025_ChIP-Seq_ESCs_Mouse1.23324296
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22442344
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22214427
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21820300
87CBP_20019798_ChIP-Seq_JUKART_Human1.21462188
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21462188
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.20773506
90FUS_26573619_Chip-Seq_HEK293_Human1.18410826
91P300_18555785_Chip-Seq_ESCs_Mouse1.17762548
92STAT3_23295773_ChIP-Seq_U87_Human1.16385067
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16021989
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.15098791
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14949709
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14884033
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.14662110
98BRD4_25478319_ChIP-Seq_HGPS_Human1.14278775
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.13287542
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.11667251
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11278224
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11139612
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10893118
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10665447
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10359285
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.10004184
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09520398
108CDX2_22108803_ChIP-Seq_LS180_Human1.08717185
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07961717
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07594712
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06690314
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06672851
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06641465
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.05933517
115MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05888618
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.05493447
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05188862
118IRF8_27001747_Chip-Seq_BMDM_Mouse1.04530258
119IRF1_19129219_ChIP-ChIP_H3396_Human1.03608682
120FLI1_27457419_Chip-Seq_LIVER_Mouse1.03468850
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03433376
122ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02549009
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.02304515
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01748306
125SOX2_19829295_ChIP-Seq_ESCs_Human1.01508003
126NANOG_19829295_ChIP-Seq_ESCs_Human1.01508003
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.01423418
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00908934
129TCF7_22412390_ChIP-Seq_EML_Mouse0.99748698
130TCF4_23295773_ChIP-Seq_U87_Human0.99528049
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99360895
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99214921
133STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99062848
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98532327
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97957806
136PU_27001747_Chip-Seq_BMDM_Mouse0.97162977
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95372610
138POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94469522
139HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91549805
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91466073
141GATA3_27048872_Chip-Seq_THYMUS_Human0.91304058
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90565707
143AR_21909140_ChIP-Seq_LNCAP_Human0.89439361
144SPI1_23547873_ChIP-Seq_NB4_Human0.89409144
145YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89370077
146SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88493298
147TFEB_21752829_ChIP-Seq_HELA_Human0.86897317
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86171226
149GATA1_22025678_ChIP-Seq_K562_Human0.85110493
150IRF8_21731497_ChIP-ChIP_J774_Mouse0.85022286
151PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84644418
152TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83673469
153FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81387879
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79347554
155MAF_26560356_Chip-Seq_TH1_Human0.75614326
156SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75012096
157SCL_19346495_ChIP-Seq_HPC-7_Human0.74876493
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73809381
159BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72167990
160EZH2_27294783_Chip-Seq_NPCs_Mouse0.71990377
161CHD1_26751641_Chip-Seq_LNCaP_Human0.71628093
162POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.71469786
163VDR_23849224_ChIP-Seq_CD4+_Human0.71467660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.96996180
2MP0003724_increased_susceptibility_to3.06844066
3MP0010234_abnormal_vibrissa_follicle2.72537160
4MP0003221_abnormal_cardiomyocyte_apopto2.57328322
5MP0010094_abnormal_chromosome_stability2.52609490
6MP0009697_abnormal_copulation2.52442763
7MP0002877_abnormal_melanocyte_morpholog2.41869166
8MP0000569_abnormal_digit_pigmentation2.29832361
9MP0002166_altered_tumor_susceptibility2.24389768
10MP0003941_abnormal_skin_development2.21238054
11MP0003567_abnormal_fetal_cardiomyocyte2.17654668
12MP0005075_abnormal_melanosome_morpholog2.11174407
13MP0003787_abnormal_imprinting2.08047503
14MP0002006_tumorigenesis2.06328893
15MP0008057_abnormal_DNA_replication2.03700938
16MP0002102_abnormal_ear_morphology2.01337107
17MP0010352_gastrointestinal_tract_polyps1.99783377
18MP0008007_abnormal_cellular_replicative1.84186502
19MP0008058_abnormal_DNA_repair1.81226350
20MP0003763_abnormal_thymus_physiology1.80888485
21MP0005076_abnormal_cell_differentiation1.79746768
22MP0003111_abnormal_nucleus_morphology1.77295871
23MP0003077_abnormal_cell_cycle1.75384016
24MP0003656_abnormal_erythrocyte_physiolo1.75039912
25MP0004484_altered_response_of1.73403712
26MP0002396_abnormal_hematopoietic_system1.68761788
27MP0003890_abnormal_embryonic-extraembry1.58473378
28MP0003300_gastrointestinal_ulcer1.54476219
29MP0003693_abnormal_embryo_hatching1.51836074
30MP0004808_abnormal_hematopoietic_stem1.50910550
31MP0000516_abnormal_urinary_system1.47147801
32MP0005367_renal/urinary_system_phenotyp1.47147801
33MP0005174_abnormal_tail_pigmentation1.46429083
34MP0010307_abnormal_tumor_latency1.45831156
35MP0000465_gastrointestinal_hemorrhage1.45607480
36MP0001873_stomach_inflammation1.41846123
37MP0004957_abnormal_blastocyst_morpholog1.40441197
38MP0006072_abnormal_retinal_apoptosis1.39984266
39MP0002254_reproductive_system_inflammat1.39584388
40MP0004947_skin_inflammation1.39069181
41MP0010678_abnormal_skin_adnexa1.32714830
42MP0003121_genomic_imprinting1.31725211
43MP0001545_abnormal_hematopoietic_system1.31137670
44MP0005397_hematopoietic_system_phenotyp1.31137670
45MP0003183_abnormal_peptide_metabolism1.30994362
46MP0003453_abnormal_keratinocyte_physiol1.30244907
47MP0005253_abnormal_eye_physiology1.28181775
48MP0000015_abnormal_ear_pigmentation1.27707965
49MP0006054_spinal_hemorrhage1.27516900
50MP0000350_abnormal_cell_proliferation1.26664238
51MP0002277_abnormal_respiratory_mucosa1.25573166
52MP0008877_abnormal_DNA_methylation1.23523176
53MP0004084_abnormal_cardiac_muscle1.21296566
54MP0000372_irregular_coat_pigmentation1.20622354
55MP0001835_abnormal_antigen_presentation1.19305440
56MP0001800_abnormal_humoral_immune1.18476740
57MP0000703_abnormal_thymus_morphology1.18349279
58MP0002060_abnormal_skin_morphology1.17379425
59MP0002095_abnormal_skin_pigmentation1.15849474
60MP0002452_abnormal_antigen_presenting1.12261823
61MP0003943_abnormal_hepatobiliary_system1.12063132
62MP0002098_abnormal_vibrissa_morphology1.11805189
63MP0009278_abnormal_bone_marrow1.11604094
64* MP0002398_abnormal_bone_marrow1.11407778
65MP0003448_altered_tumor_morphology1.10555306
66MP0008260_abnormal_autophagy1.09920425
67MP0003566_abnormal_cell_adhesion1.09264684
68MP0001216_abnormal_epidermal_layer1.08930384
69MP0000383_abnormal_hair_follicle1.08595319
70MP0003122_maternal_imprinting1.08129545
71MP0005275_abnormal_skin_tensile1.06703104
72MP0004510_myositis1.05378342
73MP0001177_atelectasis1.05012605
74MP0001984_abnormal_olfaction1.04506301
75MP0003718_maternal_effect1.02942481
76MP0004264_abnormal_extraembryonic_tissu1.02507556
77MP0003705_abnormal_hypodermis_morpholog1.02195796
78MP0001188_hyperpigmentation1.00917658
79MP0002177_abnormal_outer_ear1.00903924
80* MP0002420_abnormal_adaptive_immunity1.00648770
81MP0002132_abnormal_respiratory_system1.00593473
82* MP0001819_abnormal_immune_cell0.99020932
83MP0002086_abnormal_extraembryonic_tissu0.98320970
84MP0001324_abnormal_eye_pigmentation0.97591091
85MP0004197_abnormal_fetal_growth/weight/0.97044931
86MP0002127_abnormal_cardiovascular_syste0.96551243
87MP0003984_embryonic_growth_retardation0.96355214
88MP0004215_abnormal_myocardial_fiber0.96335398
89MP0002084_abnormal_developmental_patter0.95728939
90MP0001191_abnormal_skin_condition0.94876837
91MP0002796_impaired_skin_barrier0.94112394
92MP0001672_abnormal_embryogenesis/_devel0.92583769
93MP0005380_embryogenesis_phenotype0.92583769
94MP0003937_abnormal_limbs/digits/tail_de0.90945445
95MP0005671_abnormal_response_to0.90836598
96MP0009703_decreased_birth_body0.90503091
97* MP0002723_abnormal_immune_serum0.89790925
98MP0002405_respiratory_system_inflammati0.89759691
99MP0004883_abnormal_blood_vessel0.89195299
100MP0002928_abnormal_bile_duct0.87691513
101MP0005000_abnormal_immune_tolerance0.87301897
102MP0001915_intracranial_hemorrhage0.87057923
103MP0002933_joint_inflammation0.86843775
104MP0002722_abnormal_immune_system0.86592657
105MP0003315_abnormal_perineum_morphology0.86540765
106MP0010155_abnormal_intestine_physiology0.86144630
107MP0001697_abnormal_embryo_size0.85583812
108MP0003755_abnormal_palate_morphology0.85107350
109MP0001851_eye_inflammation0.84981515
110MP0001879_abnormal_lymphatic_vessel0.84482887
111* MP0000716_abnormal_immune_system0.84039752
112MP0002233_abnormal_nose_morphology0.83583430
113MP0005248_abnormal_Harderian_gland0.83519932
114MP0003091_abnormal_cell_migration0.83172521
115MP0001293_anophthalmia0.83171157
116MP0000733_abnormal_muscle_development0.83011390
117MP0003786_premature_aging0.82962178
118MP0003935_abnormal_craniofacial_develop0.81631090
119MP0000427_abnormal_hair_cycle0.81337829
120MP0002019_abnormal_tumor_incidence0.81211037
121MP0000377_abnormal_hair_follicle0.80967628
122MP0000689_abnormal_spleen_morphology0.80931954
123MP0005501_abnormal_skin_physiology0.80519253
124MP0001790_abnormal_immune_system0.80343636
125MP0005387_immune_system_phenotype0.80343636
126MP0002092_abnormal_eye_morphology0.80218492
127MP0000432_abnormal_head_morphology0.79910963
128MP0006292_abnormal_olfactory_placode0.79495385
129MP0003828_pulmonary_edema0.78782065
130MP0002088_abnormal_embryonic_growth/wei0.78467675
131MP0002085_abnormal_embryonic_tissue0.78314028
132MP0002138_abnormal_hepatobiliary_system0.78243261
133MP0000647_abnormal_sebaceous_gland0.77196232
134MP0002419_abnormal_innate_immunity0.76643372
135MP0005388_respiratory_system_phenotype0.74277860
136MP0002133_abnormal_respiratory_system0.74277860
137MP0001286_abnormal_eye_development0.74266989
138MP0000371_diluted_coat_color0.73589147
139MP0009785_altered_susceptibility_to0.73222541
140MP0005384_cellular_phenotype0.68023411
141MP0001929_abnormal_gametogenesis0.66998878

Predicted human phenotypes

RankGene SetZ-score
1Thyroid carcinoma (HP:0002890)3.66425093
2Volvulus (HP:0002580)3.50600038
3Lip pit (HP:0100267)3.38035172
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21303132
5Chromsome breakage (HP:0040012)3.18504407
6Rhabdomyosarcoma (HP:0002859)3.14963113
7Abnormality of the fingertips (HP:0001211)3.09619072
8Severe combined immunodeficiency (HP:0004430)2.98447039
9Amyotrophic lateral sclerosis (HP:0007354)2.86015006
10Renal cortical cysts (HP:0000803)2.74631224
11Combined immunodeficiency (HP:0005387)2.72254706
12Abnormal hair whorl (HP:0010721)2.56022093
13Dyschromatopsia (HP:0007641)2.53088313
14Colon cancer (HP:0003003)2.50785323
15Gonadotropin excess (HP:0000837)2.49885306
16B lymphocytopenia (HP:0010976)2.49478667
17Abnormality of the nasal septum (HP:0000419)2.43197771
18Prostate neoplasm (HP:0100787)2.41075312
19Abnormality of B cell number (HP:0010975)2.37973477
20Hypochromic microcytic anemia (HP:0004840)2.36389325
21Ectopic kidney (HP:0000086)2.35915047
22Panhypogammaglobulinemia (HP:0003139)2.35580292
23Neoplasm of the small intestine (HP:0100833)2.35275414
24Absent frontal sinuses (HP:0002688)2.31689323
25Medial flaring of the eyebrow (HP:0010747)2.31556825
26Bile duct proliferation (HP:0001408)2.28325236
27Abnormal biliary tract physiology (HP:0012439)2.28325236
28Optic neuritis (HP:0100653)2.25196372
29Retrobulbar optic neuritis (HP:0100654)2.25196372
30Abnormality of eosinophils (HP:0001879)2.25041774
31Abnormality of chromosome stability (HP:0003220)2.23295927
32Genital tract atresia (HP:0001827)2.19406321
33Chronic mucocutaneous candidiasis (HP:0002728)2.18882702
34Recurrent cutaneous fungal infections (HP:0011370)2.18882702
35Congenital primary aphakia (HP:0007707)2.17385943
36Breast carcinoma (HP:0003002)2.16393345
37Hypoplastic labia majora (HP:0000059)2.16357962
38Acute myeloid leukemia (HP:0004808)2.15587594
39Biliary tract neoplasm (HP:0100574)2.14978792
40Deep philtrum (HP:0002002)2.12521458
41T lymphocytopenia (HP:0005403)2.12230857
42Aqueductal stenosis (HP:0002410)2.11036847
43Pancreatic islet-cell hyperplasia (HP:0004510)2.08589597
44Exercise-induced muscle cramps (HP:0003710)2.06092541
45Gastrointestinal carcinoma (HP:0002672)2.05725613
46Malignant gastrointestinal tract tumors (HP:0006749)2.05725613
47Stomach cancer (HP:0012126)2.05612308
48Cystic hygroma (HP:0000476)2.05182358
49Nephrogenic diabetes insipidus (HP:0009806)2.04688330
50Facial diplegia (HP:0001349)2.04686162
51Abnormality of T cell number (HP:0011839)2.02790846
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.02219807
53Short tibia (HP:0005736)2.01315088
54Abnormality of the ischium (HP:0003174)2.00935242
55Papillary thyroid carcinoma (HP:0002895)2.00145418
56Transitional cell carcinoma of the bladder (HP:0006740)1.98538010
57Abnormality of the labia minora (HP:0012880)1.97432423
58Pancreatic cysts (HP:0001737)1.96202477
59Sloping forehead (HP:0000340)1.95622138
60Pancreatic fibrosis (HP:0100732)1.95017322
61Vaginal atresia (HP:0000148)1.94772161
62Myelodysplasia (HP:0002863)1.93800375
63Abnormality of the labia majora (HP:0012881)1.93435689
64Neoplasm of the colon (HP:0100273)1.93324096
65Eosinophilia (HP:0001880)1.92685986
66Abnormality of DNA repair (HP:0003254)1.91607705
67Abnormality of the musculature of the pelvis (HP:0001469)1.91377692
68Abnormality of the hip-girdle musculature (HP:0001445)1.91377692
69Hematochezia (HP:0002573)1.90701364
70Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88956857
7111 pairs of ribs (HP:0000878)1.87915539
72Hypoproteinemia (HP:0003075)1.87488634
73Bladder neoplasm (HP:0009725)1.87053352
74Bladder carcinoma (HP:0002862)1.87053352
75Abnormality of the renal cortex (HP:0011035)1.86753219
76Gait imbalance (HP:0002141)1.86301575
77Abolished electroretinogram (ERG) (HP:0000550)1.86156226
78Eczematoid dermatitis (HP:0000976)1.85249673
79Deviation of the thumb (HP:0009603)1.82442794
80Blepharitis (HP:0000498)1.81481307
81Thyroiditis (HP:0100646)1.81433307
82Leukocytosis (HP:0001974)1.81016754
83Atrophy/Degeneration involving motor neurons (HP:0007373)1.80320138
84Supernumerary spleens (HP:0009799)1.79899408
85Neoplasm of striated muscle (HP:0009728)1.79604195
86Ovarian neoplasm (HP:0100615)1.79088672
87Progressive inability to walk (HP:0002505)1.78571907
88Recurrent fungal infections (HP:0002841)1.78419156
89Abnormality of the duodenum (HP:0002246)1.78241302
90Central scotoma (HP:0000603)1.77967383
91Hypoplasia of the thymus (HP:0000778)1.77817734
92IgM deficiency (HP:0002850)1.77203947
93Abnormality of T cells (HP:0002843)1.76961120
94Medulloblastoma (HP:0002885)1.76049186
95Orchitis (HP:0100796)1.75464233
96Recurrent viral infections (HP:0004429)1.75347391
97Poor coordination (HP:0002370)1.75166075
98Spontaneous hematomas (HP:0007420)1.74464895
99Glioma (HP:0009733)1.73360869
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.72787933
101Clubbing of toes (HP:0100760)1.72603135
102Encephalitis (HP:0002383)1.72127784
103Sparse scalp hair (HP:0002209)1.70797891
104Proximal placement of thumb (HP:0009623)1.70104022
105Pelvic girdle muscle weakness (HP:0003749)1.69655204
106Clitoromegaly (HP:0000057)1.68891702
107Myositis (HP:0100614)1.68607949
108Oligodactyly (hands) (HP:0001180)1.67423172
109Abnormality of the preputium (HP:0100587)1.67168240
110Agnosia (HP:0010524)1.65289933
111Abnormality of the ileum (HP:0001549)1.65003408
112Meckel diverticulum (HP:0002245)1.64721721
113Truncal obesity (HP:0001956)1.64657649
114Uterine leiomyosarcoma (HP:0002891)1.64215754
115Leiomyosarcoma (HP:0100243)1.64215754
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.63322205
117Curly hair (HP:0002212)1.62635229
118Abnormal biliary tract morphology (HP:0012440)1.62165216
119Nephroblastoma (Wilms tumor) (HP:0002667)1.60563268
120Disinhibition (HP:0000734)1.60437007
121Limited elbow extension (HP:0001377)1.60178058
122Short 4th metacarpal (HP:0010044)1.59226773
123Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59226773
124Persistence of primary teeth (HP:0006335)1.59219732
125Dislocated radial head (HP:0003083)1.58860137
126Subacute progressive viral hepatitis (HP:0006572)1.58564398
127Ectropion (HP:0000656)1.58201769
128Long clavicles (HP:0000890)1.56883635
129Syringomyelia (HP:0003396)1.56493061
130Spinal cord lesions (HP:0100561)1.56493061
131Keratoconjunctivitis sicca (HP:0001097)1.55417086
132Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.54137480
133Abnormality of the frontal sinuses (HP:0002687)1.54077909
134Long eyelashes (HP:0000527)1.53779318
135Mediastinal lymphadenopathy (HP:0100721)1.53403363
136Intestinal atresia (HP:0011100)1.52913880
137Supernumerary ribs (HP:0005815)1.52727462
138Stomatitis (HP:0010280)1.52344032
139Macroorchidism (HP:0000053)1.51221934
140Embryonal renal neoplasm (HP:0011794)1.51178846
141Abnormality of chromosome segregation (HP:0002916)1.50717810
142Abnormality of the carotid arteries (HP:0005344)1.48141753
143Portal hypertension (HP:0001409)1.47751033
144Duodenal stenosis (HP:0100867)1.47502411
145Small intestinal stenosis (HP:0012848)1.47502411
146Rectal prolapse (HP:0002035)1.47398597
147Keratoconjunctivitis (HP:0001096)1.46360247
148Increased nuchal translucency (HP:0010880)1.45947796
149Abnormality of the radial head (HP:0003995)1.45546055
150Esophageal atresia (HP:0002032)1.45424201
151Neoplasm of the tracheobronchial system (HP:0100552)1.45199170
152Hypoplasia of the maxilla (HP:0000327)1.42986676
153Broad palm (HP:0001169)1.42577419
154Abnormality of the hepatic vasculature (HP:0006707)1.42533488
155Neoplasm of the oral cavity (HP:0100649)1.41415457
156Uterine neoplasm (HP:0010784)1.41051131
157Supernumerary bones of the axial skeleton (HP:0009144)1.39342855
158Abnormality of the prostate (HP:0008775)1.38806156
159Entropion (HP:0000621)1.38341231
160Lymphoma (HP:0002665)1.38135576
161Sandal gap (HP:0001852)1.37900638
162Facial hemangioma (HP:0000329)1.37831567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.71533497
2EIF2AK33.16065250
3MAP3K143.08796436
4BCR2.72795246
5BRD42.48771044
6CDK122.46708004
7LATS12.37659071
8CDC72.18887432
9ERBB32.18013736
10WNK32.11723138
11ACVR1B2.09948916
12STK101.98587041
13NUAK11.96441679
14FRK1.95875974
15SRPK11.94568384
16TXK1.93910901
17MKNK21.91861294
18TNIK1.87078479
19ZAK1.81294549
20BMPR1B1.77421102
21STK38L1.74598238
22CDK91.72198795
23CDK61.71856342
24SIK31.70620312
25TGFBR11.62618447
26MAP3K41.60813295
27JAK31.59478418
28FGFR31.57750437
29MKNK11.57226401
30MAP3K131.56557486
31STK31.55814527
32RPS6KB21.55521341
33RPS6KA41.54828174
34EPHA21.53083384
35CHUK1.50258103
36BMPR21.48538180
37MAP4K21.44742913
38YES11.41419155
39MELK1.39323664
40DYRK31.36821872
41MAP4K11.28391142
42ITK1.27777797
43PIK3CG1.26870828
44TTK1.23772044
45EEF2K1.22108107
46KSR11.21814412
47TYK21.21575563
48IKBKE1.20773001
49IKBKB1.20464570
50PIM11.20363938
51ATR1.18730790
52AKT31.17903540
53TEC1.17466844
54MST41.13674213
55TRPM71.12862539
56MARK31.08265485
57ATM1.06333343
58AURKB1.06149416
59BRSK21.03866707
60PBK1.03571998
61PASK1.02907658
62MAP3K31.01712444
63IRAK11.01549956
64OBSCN1.01083789
65NEK20.99958335
66PLK40.99640966
67FES0.99535956
68IRAK40.99305221
69CHEK20.97775356
70TAOK30.97342526
71STK40.96362387
72NLK0.94832109
73TGFBR20.92792614
74CDK30.90854027
75TAF10.90023638
76EPHA30.89285859
77GRK10.89225030
78PLK30.88641089
79FER0.87192514
80CHEK10.85624339
81MAP3K100.83887952
82PLK20.83541360
83RPS6KA50.83227518
84CDK190.80912206
85FLT30.79111797
86CCNB10.77600775
87JAK10.77383425
88PTK60.76229772
89PDGFRB0.75013681
90CDK70.73775018
91STK390.71547777
92FGR0.70385496
93HCK0.70286045
94SGK20.70114645
95PLK10.69649946
96EGFR0.68996546
97LCK0.68937019
98EIF2AK20.68537564
99MAP3K20.68227579
100DYRK1A0.67763327
101MAP3K60.67538893
102MAPKAPK30.66136288
103CDK40.65160581
104MAP3K50.63595092
105WEE10.62865155
106CSNK1G20.60918650
107CSK0.59834237
108STK240.59166506
109CSNK1D0.59056964
110RAF10.58247763
111CSNK1G10.58080926
112TSSK60.57805702
113CLK10.57736006
114NEK90.57670891
115DYRK1B0.56518801
116MAP3K120.56107820
117JAK20.55588637
118EIF2AK10.55512799
119TBK10.55315800
120VRK10.55192989
121FGFR20.54438537
122MOS0.54361716
123KIT0.53933767
124TTN0.53148591
125SYK0.51983364
126OXSR10.51018314
127PRKDC0.50245013
128FGFR10.50139128
129RIPK10.49667357
130BTK0.48232436
131LRRK20.48154526
132CDK20.47820416
133IRAK30.47428606
134MAP3K80.46937685
135EPHB10.46243071
136PRKCE0.45204587
137MTOR0.45171231
138LYN0.45113351
139SGK30.44947048
140PAK30.44631575
141MATK0.44513041
142AKT10.44434088
143INSRR0.44345950
144MAPK130.44214441
145CDK10.44050439
146SCYL20.42836409
147MAP2K40.42097593

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.04895122
2Protein export_Homo sapiens_hsa030602.76076062
3Propanoate metabolism_Homo sapiens_hsa006402.50460678
4Non-homologous end-joining_Homo sapiens_hsa034501.83310267
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.79167550
6Fanconi anemia pathway_Homo sapiens_hsa034601.68957379
7Transcriptional misregulation in cancer_Homo sapiens_hsa052021.55514107
8Cell cycle_Homo sapiens_hsa041101.54576456
9Regulation of autophagy_Homo sapiens_hsa041401.53067586
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51976947
11Primary immunodeficiency_Homo sapiens_hsa053401.51711029
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50297426
13MicroRNAs in cancer_Homo sapiens_hsa052061.47674635
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42376866
15p53 signaling pathway_Homo sapiens_hsa041151.41050283
16mRNA surveillance pathway_Homo sapiens_hsa030151.39588675
17Homologous recombination_Homo sapiens_hsa034401.37264653
18Herpes simplex infection_Homo sapiens_hsa051681.36751592
19Measles_Homo sapiens_hsa051621.35731351
20T cell receptor signaling pathway_Homo sapiens_hsa046601.35549105
21Osteoclast differentiation_Homo sapiens_hsa043801.34030658
22Antigen processing and presentation_Homo sapiens_hsa046121.31881157
23Mismatch repair_Homo sapiens_hsa034301.29913141
24Hematopoietic cell lineage_Homo sapiens_hsa046401.29600376
25Chronic myeloid leukemia_Homo sapiens_hsa052201.29240547
26RNA degradation_Homo sapiens_hsa030181.26005441
27B cell receptor signaling pathway_Homo sapiens_hsa046621.24994761
28Leishmaniasis_Homo sapiens_hsa051401.23362864
29Small cell lung cancer_Homo sapiens_hsa052221.23048048
30Adherens junction_Homo sapiens_hsa045201.22547049
31Asthma_Homo sapiens_hsa053101.21806257
32Viral carcinogenesis_Homo sapiens_hsa052031.21486556
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20420748
34Systemic lupus erythematosus_Homo sapiens_hsa053221.19444406
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19189129
36Hepatitis B_Homo sapiens_hsa051611.17765886
37HTLV-I infection_Homo sapiens_hsa051661.17091878
38Graft-versus-host disease_Homo sapiens_hsa053321.16571843
39TNF signaling pathway_Homo sapiens_hsa046681.15688449
40Colorectal cancer_Homo sapiens_hsa052101.12301193
41Pancreatic cancer_Homo sapiens_hsa052121.11891596
42Prostate cancer_Homo sapiens_hsa052151.11584600
43Spliceosome_Homo sapiens_hsa030401.11335628
44RNA transport_Homo sapiens_hsa030131.10509060
45Oocyte meiosis_Homo sapiens_hsa041141.08171123
46Toxoplasmosis_Homo sapiens_hsa051451.06560160
47TGF-beta signaling pathway_Homo sapiens_hsa043501.03839966
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03542554
49Steroid biosynthesis_Homo sapiens_hsa001001.03034172
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02358378
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02248633
52Influenza A_Homo sapiens_hsa051641.02000092
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01719363
54Type I diabetes mellitus_Homo sapiens_hsa049401.01506485
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01469288
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00848051
57Base excision repair_Homo sapiens_hsa034101.00784518
58FoxO signaling pathway_Homo sapiens_hsa040680.99579131
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.98895584
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.97662098
61Apoptosis_Homo sapiens_hsa042100.96578828
62Basal transcription factors_Homo sapiens_hsa030220.95434904
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.94741364
64Staphylococcus aureus infection_Homo sapiens_hsa051500.94409264
65DNA replication_Homo sapiens_hsa030300.92632651
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92469127
67Legionellosis_Homo sapiens_hsa051340.91232451
68Dorso-ventral axis formation_Homo sapiens_hsa043200.89710743
69Acute myeloid leukemia_Homo sapiens_hsa052210.89508167
70Prolactin signaling pathway_Homo sapiens_hsa049170.88218065
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87745903
72Epstein-Barr virus infection_Homo sapiens_hsa051690.87425393
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87300146
74Circadian rhythm_Homo sapiens_hsa047100.87195227
75Endometrial cancer_Homo sapiens_hsa052130.86209919
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85760680
77Nucleotide excision repair_Homo sapiens_hsa034200.85127993
78Non-small cell lung cancer_Homo sapiens_hsa052230.84748605
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84269808
80Hippo signaling pathway_Homo sapiens_hsa043900.81275588
81Chemokine signaling pathway_Homo sapiens_hsa040620.80043279
82Pathways in cancer_Homo sapiens_hsa052000.78762008
83Proteoglycans in cancer_Homo sapiens_hsa052050.78751806
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77792803
85Viral myocarditis_Homo sapiens_hsa054160.77659908
86Platelet activation_Homo sapiens_hsa046110.75992692
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75908472
88Inositol phosphate metabolism_Homo sapiens_hsa005620.75172459
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74806666
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73585882
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73361113
92Autoimmune thyroid disease_Homo sapiens_hsa053200.73275938
93Olfactory transduction_Homo sapiens_hsa047400.71934691
94Tuberculosis_Homo sapiens_hsa051520.71776235
95Focal adhesion_Homo sapiens_hsa045100.71597576
96Notch signaling pathway_Homo sapiens_hsa043300.71106948
97Hepatitis C_Homo sapiens_hsa051600.71049247
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70867317
99ECM-receptor interaction_Homo sapiens_hsa045120.70864098
100Alcoholism_Homo sapiens_hsa050340.70380479
101Phototransduction_Homo sapiens_hsa047440.70259480
102Allograft rejection_Homo sapiens_hsa053300.69271677
103Thyroid cancer_Homo sapiens_hsa052160.69112462
104Wnt signaling pathway_Homo sapiens_hsa043100.68689719
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68454938
106Peroxisome_Homo sapiens_hsa041460.67213756
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65567209
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.65214302
109mTOR signaling pathway_Homo sapiens_hsa041500.64908545
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63758771
111Shigellosis_Homo sapiens_hsa051310.63740299
112Basal cell carcinoma_Homo sapiens_hsa052170.63637635
113ErbB signaling pathway_Homo sapiens_hsa040120.62221977
114MAPK signaling pathway_Homo sapiens_hsa040100.59749662
115Malaria_Homo sapiens_hsa051440.58582380
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58492930
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57760016
118Long-term depression_Homo sapiens_hsa047300.56086434
119Ether lipid metabolism_Homo sapiens_hsa005650.51298119
120HIF-1 signaling pathway_Homo sapiens_hsa040660.51165748
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50827744
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.47787154
123Butanoate metabolism_Homo sapiens_hsa006500.45633955
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.44927105
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41651237
126Taste transduction_Homo sapiens_hsa047420.40065094
127Selenocompound metabolism_Homo sapiens_hsa004500.39335527
128Sphingolipid metabolism_Homo sapiens_hsa006000.38982970
129Fatty acid elongation_Homo sapiens_hsa000620.33554875
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.31276140

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