MARCH8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.28018755
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.81121664
3negative regulation of cell killing (GO:0031342)5.81121664
4regulation of B cell receptor signaling pathway (GO:0050855)5.55672808
5L-phenylalanine catabolic process (GO:0006559)5.39759887
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.39759887
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.23601249
8microglial cell activation (GO:0001774)4.98669072
9L-phenylalanine metabolic process (GO:0006558)4.88280529
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.88280529
11positive regulation by symbiont of host defense response (GO:0052509)4.76094421
12modulation by symbiont of host defense response (GO:0052031)4.76094421
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.76094421
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.76094421
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.76094421
16modulation by symbiont of host immune response (GO:0052553)4.76094421
17regulation of gamma-delta T cell differentiation (GO:0045586)4.64881495
18regulation of gamma-delta T cell activation (GO:0046643)4.62221094
19hepatocyte apoptotic process (GO:0097284)4.54913952
20detection of molecule of bacterial origin (GO:0032490)4.54138899
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.53727299
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.47189068
23fatty acid elongation (GO:0030497)4.18746718
24positive thymic T cell selection (GO:0045059)4.18011700
25positive T cell selection (GO:0043368)4.15875732
26aromatic amino acid family catabolic process (GO:0009074)4.12991423
27alpha-linolenic acid metabolic process (GO:0036109)4.10141092
28glyoxylate metabolic process (GO:0046487)4.09010688
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08283593
30cellular extravasation (GO:0045123)4.04747918
31axon ensheathment in central nervous system (GO:0032291)4.02675372
32central nervous system myelination (GO:0022010)4.02675372
33macrophage activation involved in immune response (GO:0002281)3.99745240
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.93999009
35negative T cell selection (GO:0043383)3.92902630
36B cell receptor signaling pathway (GO:0050853)3.88205801
37negative thymic T cell selection (GO:0045060)3.86779802
38cysteine metabolic process (GO:0006534)3.86304597
39positive regulation of granulocyte differentiation (GO:0030854)3.85953982
40antigen processing and presentation of endogenous antigen (GO:0019883)3.85892294
41macrophage activation (GO:0042116)3.84918599
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.84881710
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.84409145
44detection of other organism (GO:0098543)3.83531058
45detection of external biotic stimulus (GO:0098581)3.82697370
46histone H3-K36 demethylation (GO:0070544)3.71362869
47negative regulation of T cell mediated immunity (GO:0002710)3.68857624
48neutrophil activation involved in immune response (GO:0002283)3.68749597
49neutrophil mediated immunity (GO:0002446)3.66888038
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56662016
51response to methylmercury (GO:0051597)3.54686577
52negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.53803275
53protoporphyrinogen IX metabolic process (GO:0046501)3.52384728
54regulation of necroptotic process (GO:0060544)3.52182075
55phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.51736016
56bile acid biosynthetic process (GO:0006699)3.51678877
57long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.49861165
58response to interleukin-15 (GO:0070672)3.47793700
59fatty-acyl-CoA biosynthetic process (GO:0046949)3.45885384
60positive regulation of receptor recycling (GO:0001921)3.44359570
61positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.42285243
62sulfur amino acid catabolic process (GO:0000098)3.41952019
63detection of bacterium (GO:0016045)3.41079178
64cholesterol biosynthetic process (GO:0006695)3.38994249
65very long-chain fatty acid metabolic process (GO:0000038)3.38268784
66myeloid leukocyte mediated immunity (GO:0002444)3.37430118
67erythrocyte development (GO:0048821)3.37114662
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.37038704
69response to host immune response (GO:0052572)3.35525671
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.35525671
71coenzyme catabolic process (GO:0009109)3.34648844
72acetyl-CoA metabolic process (GO:0006084)3.32351819
73protein carboxylation (GO:0018214)3.30840649
74peptidyl-glutamic acid carboxylation (GO:0017187)3.30840649
75activated T cell proliferation (GO:0050798)3.29891446
76regulation of beta-amyloid formation (GO:1902003)3.28294258
77negative regulation of leukocyte mediated immunity (GO:0002704)3.27726520
78detection of biotic stimulus (GO:0009595)3.27013532
79regulation of platelet aggregation (GO:0090330)3.25878124
80T cell selection (GO:0045058)3.24644694
81oxygen transport (GO:0015671)3.23614893
82cellular ketone body metabolic process (GO:0046950)3.22391227
83negative regulation of interleukin-12 production (GO:0032695)3.21815184
84acyl-CoA biosynthetic process (GO:0071616)3.20643356
85thioester biosynthetic process (GO:0035384)3.20643356
86drug transmembrane transport (GO:0006855)3.20611798
87short-chain fatty acid metabolic process (GO:0046459)3.19612366
88regulation of B cell differentiation (GO:0045577)3.19291761
89tyrosine metabolic process (GO:0006570)3.18931397
90lysine metabolic process (GO:0006553)3.17311909
91lysine catabolic process (GO:0006554)3.17311909
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.14884687
93leukocyte aggregation (GO:0070486)3.14838624
94response to host (GO:0075136)3.13566950
95response to host defenses (GO:0052200)3.13566950
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.13566950
97bile acid metabolic process (GO:0008206)3.12514702
98regulation of interferon-beta biosynthetic process (GO:0045357)3.10902923
99plasma lipoprotein particle clearance (GO:0034381)3.09646667
100myeloid cell activation involved in immune response (GO:0002275)3.06469902
101heme transport (GO:0015886)3.06034958
102negative regulation of erythrocyte differentiation (GO:0045647)3.06028655
103positive regulation of B cell differentiation (GO:0045579)3.05047066
104negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04670198
105myeloid cell development (GO:0061515)3.04350383
106neutrophil activation (GO:0042119)3.03874874
107respiratory burst (GO:0045730)3.03315560
108hemoglobin metabolic process (GO:0020027)3.02499986
109fatty-acyl-CoA metabolic process (GO:0035337)3.02300208
110high-density lipoprotein particle remodeling (GO:0034375)2.99063094
111glutamate metabolic process (GO:0006536)2.98758242
112thymic T cell selection (GO:0045061)2.98590309
113indole-containing compound catabolic process (GO:0042436)2.98149591
114indolalkylamine catabolic process (GO:0046218)2.98149591
115tryptophan catabolic process (GO:0006569)2.98149591
116T cell migration (GO:0072678)2.97497775
117complement activation, alternative pathway (GO:0006957)2.96382226
118regulation of amyloid precursor protein catabolic process (GO:1902991)2.95806453
119kynurenine metabolic process (GO:0070189)2.94867269
120tryptophan metabolic process (GO:0006568)2.93698050
121sterol biosynthetic process (GO:0016126)2.93190766
122intestinal cholesterol absorption (GO:0030299)2.92945164
123regulation of granulocyte differentiation (GO:0030852)2.91642071
124cellular response to interleukin-15 (GO:0071350)2.91334580
125negative regulation of B cell proliferation (GO:0030889)2.91207217
126positive regulation of insulin receptor signaling pathway (GO:0046628)2.90673061
127negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89078736
128aromatic amino acid family metabolic process (GO:0009072)2.88583625
129aspartate family amino acid catabolic process (GO:0009068)2.87281381
130negative regulation of fibrinolysis (GO:0051918)2.86644934
131axon ensheathment (GO:0008366)2.85598533
132ensheathment of neurons (GO:0007272)2.85598533
133antigen processing and presentation via MHC class Ib (GO:0002475)2.84968025
134long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.83438488
135myelination (GO:0042552)2.83196874
136homocysteine metabolic process (GO:0050667)2.82517721
137cholesterol efflux (GO:0033344)2.82169307
138negative regulation of immunoglobulin mediated immune response (GO:0002890)2.81614055
139negative regulation of B cell mediated immunity (GO:0002713)2.81614055
140ketone body metabolic process (GO:1902224)2.81389136
141very-low-density lipoprotein particle assembly (GO:0034379)2.81070815
142cellular modified amino acid catabolic process (GO:0042219)2.80534958
143reverse cholesterol transport (GO:0043691)2.79227386
144negative regulation of adaptive immune response (GO:0002820)2.77026530
145negative regulation of T-helper cell differentiation (GO:0045623)2.76605319
146negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.76605319
147ethanol oxidation (GO:0006069)2.76100321
148protein K11-linked deubiquitination (GO:0035871)2.76053856
149macroautophagy (GO:0016236)2.75355131
150response to peptidoglycan (GO:0032494)2.75038894
151triglyceride homeostasis (GO:0070328)2.74446632
152acylglycerol homeostasis (GO:0055090)2.74446632
153response to mercury ion (GO:0046689)2.74251309
154regulation of fibrinolysis (GO:0051917)2.74213410
155acyl-CoA metabolic process (GO:0006637)2.73875247
156thioester metabolic process (GO:0035383)2.73875247
157cellular response to epinephrine stimulus (GO:0071872)2.72992880
158regulation of triglyceride catabolic process (GO:0010896)2.72759374
159granulocyte activation (GO:0036230)2.72349566
160regulation of cellular amide metabolic process (GO:0034248)2.72215629
161drug catabolic process (GO:0042737)2.71998710
162fatty acid beta-oxidation (GO:0006635)2.71981863
163urea cycle (GO:0000050)2.71815986
164urea metabolic process (GO:0019627)2.71815986
165regulation of protein activation cascade (GO:2000257)2.70910992
166regulation of mast cell degranulation (GO:0043304)2.70545063
167regulation of cholesterol homeostasis (GO:2000188)2.70222933
168regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70073177
169alpha-amino acid catabolic process (GO:1901606)2.68753067
170megakaryocyte development (GO:0035855)2.68650795
171gas transport (GO:0015669)2.68585774
172fatty acid oxidation (GO:0019395)2.67523053
173cofactor catabolic process (GO:0051187)2.67202490
174creatine metabolic process (GO:0006600)2.66889783
175regulation of myeloid leukocyte mediated immunity (GO:0002886)2.65809448
176negative regulation of glial cell proliferation (GO:0060253)2.65621706
177positive regulation of cellular amide metabolic process (GO:0034250)2.65447339
178fatty acid catabolic process (GO:0009062)2.64604424
179regulation of cholesterol biosynthetic process (GO:0045540)2.64300376
180cellular amino acid catabolic process (GO:0009063)2.64061582
181dendritic cell migration (GO:0036336)2.63792690
182regulation of cholesterol metabolic process (GO:0090181)2.63167647
183cholesterol metabolic process (GO:0008203)2.63035614
184lipid oxidation (GO:0034440)2.62201916
185import into cell (GO:0098657)2.59380462
186protein-lipid complex assembly (GO:0065005)2.58847120
187plasma lipoprotein particle assembly (GO:0034377)2.57510758
188monocarboxylic acid catabolic process (GO:0072329)2.56534694
189response to lipoprotein particle (GO:0055094)2.56135973
190myelin maintenance (GO:0043217)2.56116975
191regulation of complement activation (GO:0030449)2.55260599
192nitrogen cycle metabolic process (GO:0071941)2.51267894
193negative regulation of lipase activity (GO:0060192)2.50629993
194amino-acid betaine metabolic process (GO:0006577)2.50101314
195plasma lipoprotein particle remodeling (GO:0034369)2.49764217
196protein-lipid complex remodeling (GO:0034368)2.49764217
197macromolecular complex remodeling (GO:0034367)2.49764217
198cholesterol homeostasis (GO:0042632)2.47505722
199sterol homeostasis (GO:0055092)2.45302537
200phospholipid efflux (GO:0033700)2.45250695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.42250299
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.69954778
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.53041822
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.33338473
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.99385412
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.60883100
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.51058418
8SCL_19346495_ChIP-Seq_HPC-7_Human3.30481861
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.25736869
10RUNX_20019798_ChIP-Seq_JUKART_Human3.08746466
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03721278
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.95830310
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.95341109
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.90846919
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.84547974
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.84405395
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.82602568
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.78626887
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.67521745
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64514570
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.58302846
22MYB_26560356_Chip-Seq_TH2_Human2.45384303
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.41382711
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.37210393
25SPI1_23127762_ChIP-Seq_K562_Human2.33124205
26GATA1_19941827_ChIP-Seq_MEL_Mouse2.29516511
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23021717
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20067976
29TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.14774310
30MYB_26560356_Chip-Seq_TH1_Human2.12256427
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03907375
32SPI1_23547873_ChIP-Seq_NB4_Human1.96811839
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96679618
34VDR_24763502_ChIP-Seq_THP-1_Human1.95782737
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93634172
36MAF_26560356_Chip-Seq_TH1_Human1.89192505
37GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.83608319
38GATA3_27048872_Chip-Seq_THYMUS_Human1.82242602
39VDR_24787735_ChIP-Seq_THP-1_Human1.81304014
40TCF7_22412390_ChIP-Seq_EML_Mouse1.77851277
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.66956922
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.64287231
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63862501
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63499290
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.62266932
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61293714
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61107864
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.60070445
49UTX_26944678_Chip-Seq_JUKART_Human1.57765242
50VDR_21846776_ChIP-Seq_THP-1_Human1.57421975
51KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.54906729
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54896381
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54701279
54MYC_22102868_ChIP-Seq_BL_Human1.53342359
55CLOCK_20551151_ChIP-Seq_293T_Human1.50367106
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50243386
57GBX2_23144817_ChIP-Seq_PC3_Human1.48292880
58PU_27001747_Chip-Seq_BMDM_Mouse1.47894049
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46682528
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46264521
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43285551
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42622735
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42310119
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42310119
65KDM2B_26808549_Chip-Seq_DND41_Human1.40621420
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40315965
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40263022
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.39708177
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.38661059
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37029289
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35196512
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34518726
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33824747
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.33204436
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32785711
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32233637
77GATA1_22025678_ChIP-Seq_K562_Human1.30868774
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30340974
79GATA1_19941826_ChIP-Seq_K562_Human1.30080441
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29307037
81GATA3_26560356_Chip-Seq_TH2_Human1.29007866
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.27954557
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27719318
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26807224
85GATA1_19941827_ChIP-Seq_MEL86_Mouse1.22994845
86DROSHA_22980978_ChIP-Seq_HELA_Human1.22782535
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21699908
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18001303
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.17987656
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16429093
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.15996659
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15641602
93MAF_26560356_Chip-Seq_TH2_Human1.14426884
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13537509
95EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12242686
96RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12242686
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11862828
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11594459
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11256308
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09423254
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.08744885
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.08344559
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07480451
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05576715
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05381365
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05281873
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05264998
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05131331
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04303197
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03918393
111FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03815475
112EED_16625203_ChIP-ChIP_MESCs_Mouse1.03728670
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03244415
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03213210
115SOX2_20726797_ChIP-Seq_SW620_Human1.02925588
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02833231
117AR_21572438_ChIP-Seq_LNCaP_Human1.01800551
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01199766
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00561404
120NCOR1_26117541_ChIP-Seq_K562_Human1.00316283
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99657189
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98699804
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.98610546
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.98435652
125SMRT_27268052_Chip-Seq_Bcells_Human0.98034064
126ESR1_21235772_ChIP-Seq_MCF-7_Human0.97302312
127JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94764924
128CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94645254
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94440356
130HTT_18923047_ChIP-ChIP_STHdh_Human0.94037645
131JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93271117
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92918959
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92325909
134TP53_16413492_ChIP-PET_HCT116_Human0.92253004
135PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92224436
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91662625
137TAF15_26573619_Chip-Seq_HEK293_Human0.90918759
138AHR_22903824_ChIP-Seq_MCF-7_Human0.90404745
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.89617282
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.87703785
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86740234
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.85991891
143EZH2_27304074_Chip-Seq_ESCs_Mouse0.85511832
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.85233720
145HNF4A_19822575_ChIP-Seq_HepG2_Human0.85186691
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84998986
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84378760
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84274520
149GATA4_25053715_ChIP-Seq_YYC3_Human0.83436813
150EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82907702
151SOX2_21211035_ChIP-Seq_LN229_Gbm0.82633969
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82576040
153TP63_23658742_ChIP-Seq_EP156T_Human0.82567771
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.82251753
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81908648
156STAT3_23295773_ChIP-Seq_U87_Human0.81152056
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80971690
158GATA2_19941826_ChIP-Seq_K562_Human0.80644726
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80255393
160Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80074054
161RNF2_27304074_Chip-Seq_ESCs_Mouse0.79787444
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.79664855
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78793476
164PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78761583
165CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78319139
166PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78022371
167SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77337887
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75032516
169FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74081459
170NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74044035
171MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.73669152
172CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73213106
173STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.73034549
174TBX20_22328084_ChIP-Seq_HEART_Mouse0.72911175
175TBX20_22080862_ChIP-Seq_HEART_Mouse0.72911175
176CJUN_26792858_Chip-Seq_BT549_Human0.72053749
177CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71979669
178RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71868969
179CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71808048
180GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71744129
181KDM2B_26808549_Chip-Seq_K562_Human0.71615956
182SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.70413813
183GATA3_26560356_Chip-Seq_TH1_Human0.69666545
184DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.69011651
185SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.65751492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.84345358
2MP0005360_urolithiasis5.14961181
3MP0008260_abnormal_autophagy4.59797767
4MP0005085_abnormal_gallbladder_physiolo4.06672564
5MP0005365_abnormal_bile_salt3.99893610
6MP0000569_abnormal_digit_pigmentation3.99123430
7MP0003195_calcinosis3.68003446
8MP0003724_increased_susceptibility_to3.49660412
9MP0008875_abnormal_xenobiotic_pharmacok3.31044677
10MP0003303_peritoneal_inflammation3.30510089
11MP0001835_abnormal_antigen_presentation2.99856267
12MP0003252_abnormal_bile_duct2.92712521
13MP0003806_abnormal_nucleotide_metabolis2.65407647
14MP0005083_abnormal_biliary_tract2.64801157
15MP0003763_abnormal_thymus_physiology2.64686163
16MP0004043_abnormal_pH_regulation2.59401274
17MP0003436_decreased_susceptibility_to2.55741389
18MP0001666_abnormal_nutrient_absorption2.52874944
19MP0000920_abnormal_myelination2.45995647
20MP0005464_abnormal_platelet_physiology2.44532883
21MP0000685_abnormal_immune_system2.43136275
22MP0001800_abnormal_humoral_immune2.41644914
23MP0003690_abnormal_glial_cell2.41438186
24MP0010329_abnormal_lipoprotein_level2.34632210
25MP0005332_abnormal_amino_acid2.20755926
26MP0002419_abnormal_innate_immunity2.19124304
27MP0009840_abnormal_foam_cell2.18466728
28MP0004381_abnormal_hair_follicle2.14090415
29MP0005025_abnormal_response_to2.08239790
30MP0000015_abnormal_ear_pigmentation2.05515827
31MP0002420_abnormal_adaptive_immunity1.99706150
32MP0002118_abnormal_lipid_homeostasis1.97770294
33MP0001819_abnormal_immune_cell1.96619947
34MP0002398_abnormal_bone_marrow1.95174312
35MP0002723_abnormal_immune_serum1.92757356
36MP0005000_abnormal_immune_tolerance1.91416702
37MP0004883_abnormal_blood_vessel1.88174485
38MP0002452_abnormal_antigen_presenting1.85940701
39MP0003656_abnormal_erythrocyte_physiolo1.85729194
40MP0005387_immune_system_phenotype1.85257848
41MP0001790_abnormal_immune_system1.85257848
42MP0003329_amyloid_beta_deposits1.83496728
43MP0009780_abnormal_chondrocyte_physiolo1.83285284
44MP0003787_abnormal_imprinting1.83005673
45MP0005671_abnormal_response_to1.81077723
46MP0002166_altered_tumor_susceptibility1.79777062
47MP0002405_respiratory_system_inflammati1.79497870
48MP0003868_abnormal_feces_composition1.78266573
49MP0009785_altered_susceptibility_to1.73262640
50MP0003828_pulmonary_edema1.72905614
51MP0002396_abnormal_hematopoietic_system1.69743822
52MP0005174_abnormal_tail_pigmentation1.68788586
53MP0005075_abnormal_melanosome_morpholog1.67474211
54MP0000689_abnormal_spleen_morphology1.67252617
55MP0000716_abnormal_immune_system1.65819693
56MP0002722_abnormal_immune_system1.64537454
57MP0005310_abnormal_salivary_gland1.62912204
58MP0000703_abnormal_thymus_morphology1.58307343
59MP0003866_abnormal_defecation1.55310036
60MP0003221_abnormal_cardiomyocyte_apopto1.52597875
61MP0004808_abnormal_hematopoietic_stem1.52409714
62MP0005397_hematopoietic_system_phenotyp1.48798642
63MP0001545_abnormal_hematopoietic_system1.48798642
64MP0004885_abnormal_endolymph1.48424609
65MP0005058_abnormal_lysosome_morphology1.47563955
66MP0009643_abnormal_urine_homeostasis1.46904119
67MP0003191_abnormal_cellular_cholesterol1.45885187
68MP0004019_abnormal_vitamin_homeostasis1.44453271
69MP0004947_skin_inflammation1.44069153
70MP0000604_amyloidosis1.41962053
71MP0008057_abnormal_DNA_replication1.41015088
72MP0002429_abnormal_blood_cell1.40678585
73MP0002332_abnormal_exercise_endurance1.38382671
74MP0006082_CNS_inflammation1.32447239
75MP0000609_abnormal_liver_physiology1.30529710
76MP0004147_increased_porphyrin_level1.27722780
77MP0001845_abnormal_inflammatory_respons1.27596272
78MP0000462_abnormal_digestive_system1.25505271
79MP0005584_abnormal_enzyme/coenzyme_acti1.24911947
80MP0002132_abnormal_respiratory_system1.23832030
81MP0005451_abnormal_body_composition1.22812585
82MP0010155_abnormal_intestine_physiology1.21964532
83MP0002138_abnormal_hepatobiliary_system1.21055001
84MP0004484_altered_response_of1.20687585
85MP0004185_abnormal_adipocyte_glucose1.19803438
86MP0003634_abnormal_glial_cell1.19436194
87MP0005636_abnormal_mineral_homeostasis1.19168242
88MP0004130_abnormal_muscle_cell1.19032903
89MP0005164_abnormal_response_to1.18835632
90MP0001661_extended_life_span1.18240055
91MP0008438_abnormal_cutaneous_collagen1.16732449
92MP0001851_eye_inflammation1.16572106
93MP0002148_abnormal_hypersensitivity_rea1.10970991
94MP0009333_abnormal_splenocyte_physiolog1.09474404
95MP0002078_abnormal_glucose_homeostasis1.08835235
96MP0001533_abnormal_skeleton_physiology1.08812423
97MP0000858_altered_metastatic_potential1.07689010
98MP0000465_gastrointestinal_hemorrhage1.07018099
99MP0003091_abnormal_cell_migration1.03984696
100MP0009278_abnormal_bone_marrow1.02788520
101MP0001756_abnormal_urination1.02234190
102MP0005408_hypopigmentation1.01792340
103MP0002006_tumorigenesis1.01294974
104MP0001765_abnormal_ion_homeostasis1.00939596
105MP0004270_analgesia1.00668950
106MP0005319_abnormal_enzyme/_coenzyme0.98825408
107MP0002837_dystrophic_cardiac_calcinosis0.98020982
108MP0002909_abnormal_adrenal_gland0.97893095
109MP0000003_abnormal_adipose_tissue0.95880237
110MP0005220_abnormal_exocrine_pancreas0.95827626
111MP0009764_decreased_sensitivity_to0.94691810
112MP0003300_gastrointestinal_ulcer0.92143399
113MP0005535_abnormal_body_temperature0.92138093
114MP0003283_abnormal_digestive_organ0.91993110
115MP0008877_abnormal_DNA_methylation0.91212399
116MP0002896_abnormal_bone_mineralization0.90903608
117MP0008995_early_reproductive_senescence0.89701743
118MP0008469_abnormal_protein_level0.88717264
119MP0004742_abnormal_vestibular_system0.88072552
120MP0002090_abnormal_vision0.88014624
121MP0003632_abnormal_nervous_system0.87800977
122MP0005409_darkened_coat_color0.87712919
123MP0001299_abnormal_eye_distance/0.87495910
124MP0010678_abnormal_skin_adnexa0.87394784
125MP0005375_adipose_tissue_phenotype0.87117716
126MP0003705_abnormal_hypodermis_morpholog0.86897741
127MP0000013_abnormal_adipose_tissue0.85242211
128MP0005666_abnormal_adipose_tissue0.84945173
129MP0002229_neurodegeneration0.84373363
130MP0002295_abnormal_pulmonary_circulatio0.83655389
131MP0002009_preneoplasia0.82854040
132MP0003045_fibrosis0.80617266
133MP0008874_decreased_physiological_sensi0.80107672
134MP0002998_abnormal_bone_remodeling0.80007561
135MP0002971_abnormal_brown_adipose0.79575459
136MP0001958_emphysema0.79372562
137MP0001485_abnormal_pinna_reflex0.77723046
138MP0001944_abnormal_pancreas_morphology0.76965029
139MP0004272_abnormal_basement_membrane0.76560800
140MP0002168_other_aberrant_phenotype0.75965666
141MP0000747_muscle_weakness0.75708337
142MP0009763_increased_sensitivity_to0.75260712
143MP0001663_abnormal_digestive_system0.74585102
144MP0000371_diluted_coat_color0.73518076
145MP0003633_abnormal_nervous_system0.72675266
146MP0005376_homeostasis/metabolism_phenot0.72528592
147MP0009384_cardiac_valve_regurgitation0.72471924
148MP0002877_abnormal_melanocyte_morpholog0.72074121
149MP0002876_abnormal_thyroid_physiology0.71778229
150MP0003172_abnormal_lysosome_physiology0.71513671
151MP0005621_abnormal_cell_physiology0.70549120
152MP0000249_abnormal_blood_vessel0.70280487
153MP0001346_abnormal_lacrimal_gland0.69918166
154MP0000230_abnormal_systemic_arterial0.69917362
155MP0005334_abnormal_fat_pad0.69777711
156MP0000778_abnormal_nervous_system0.69650421
157MP0001177_atelectasis0.68031800
158MP0008004_abnormal_stomach_pH0.66136153
159MP0001915_intracranial_hemorrhage0.65607426
160MP0003631_nervous_system_phenotype0.65290413
161MP0005076_abnormal_cell_differentiation0.64433437
162MP0004510_myositis0.63692983
163MP0010386_abnormal_urinary_bladder0.63162275
164MP0003950_abnormal_plasma_membrane0.63105791
165MP0005448_abnormal_energy_balance0.62374633
166MP0009765_abnormal_xenobiotic_induced0.60528846
167MP0001486_abnormal_startle_reflex0.60459292
168MP0009642_abnormal_blood_homeostasis0.60334713
169MP0000639_abnormal_adrenal_gland0.59779986
170MP0003959_abnormal_lean_body0.59382551
171MP0003183_abnormal_peptide_metabolism0.59230922
172MP0003453_abnormal_keratinocyte_physiol0.59230670
173MP0003953_abnormal_hormone_level0.58897833
174MP0010307_abnormal_tumor_latency0.58669528
175MP0002693_abnormal_pancreas_physiology0.55444164
176MP0004264_abnormal_extraembryonic_tissu0.55165181
177MP0000538_abnormal_urinary_bladder0.54406648
178MP0002254_reproductive_system_inflammat0.53706126
179MP0010234_abnormal_vibrissa_follicle0.52665499
180MP0005379_endocrine/exocrine_gland_phen0.52413600
181MP0005248_abnormal_Harderian_gland0.52357111
182MP0000647_abnormal_sebaceous_gland0.52129461
183MP0005670_abnormal_white_adipose0.51892180

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.58727398
2Recurrent bacterial skin infections (HP:0005406)5.40555872
3Eczematoid dermatitis (HP:0000976)5.02456857
4Recurrent abscess formation (HP:0002722)4.92763736
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.88372711
6Intrahepatic cholestasis (HP:0001406)4.79007950
7T lymphocytopenia (HP:0005403)4.49536161
8Deep venous thrombosis (HP:0002625)4.48774583
9Gastrointestinal infarctions (HP:0005244)4.32000354
10Xanthomatosis (HP:0000991)4.26230864
11Abnormality of T cell number (HP:0011839)4.16218224
12Myositis (HP:0100614)4.04445841
13Microcytic anemia (HP:0001935)3.96041372
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.91415556
15Orchitis (HP:0100796)3.87358923
16Gingival bleeding (HP:0000225)3.87262047
17Optic neuritis (HP:0100653)3.86093295
18Retrobulbar optic neuritis (HP:0100654)3.86093295
19Neurofibrillary tangles (HP:0002185)3.83783865
20Recurrent fungal infections (HP:0002841)3.80454878
21Spontaneous hematomas (HP:0007420)3.62042360
22Slow saccadic eye movements (HP:0000514)3.61278523
23Hypoglycemic coma (HP:0001325)3.60092986
24Recurrent gram-negative bacterial infections (HP:0005420)3.59347354
25Hypochromic anemia (HP:0001931)3.56551046
26Ketosis (HP:0001946)3.56394801
27Prolonged bleeding time (HP:0003010)3.56043902
28Gingivitis (HP:0000230)3.50415897
29Recurrent skin infections (HP:0001581)3.49616394
30Hyperlipoproteinemia (HP:0010980)3.43094702
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.36820454
32Abnormality of macrophages (HP:0004311)3.32747566
33Ketoacidosis (HP:0001993)3.32375732
34Hypoglycemic seizures (HP:0002173)3.28931777
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.25867369
36Prolonged partial thromboplastin time (HP:0003645)3.25617603
37Stomatitis (HP:0010280)3.20674921
38Cerebral inclusion bodies (HP:0100314)3.13903103
39Peritonitis (HP:0002586)3.13662018
40Postural instability (HP:0002172)3.11076510
41Epistaxis (HP:0000421)3.10259869
42Epidermoid cyst (HP:0200040)3.10234396
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.09294884
44Degeneration of the lateral corticospinal tracts (HP:0002314)3.09294884
45Hyperinsulinemic hypoglycemia (HP:0000825)3.09123636
46Complement deficiency (HP:0004431)3.07688965
47Recurrent cutaneous fungal infections (HP:0011370)3.03997002
48Chronic mucocutaneous candidiasis (HP:0002728)3.03997002
49Elevated erythrocyte sedimentation rate (HP:0003565)3.02871923
50Keratoconjunctivitis sicca (HP:0001097)3.00862352
51Abnormality of the common coagulation pathway (HP:0010990)2.93127508
52Recurrent viral infections (HP:0004429)2.92962605
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.92444565
54Meningitis (HP:0001287)2.90312747
55Conjugated hyperbilirubinemia (HP:0002908)2.89662363
56Hypobetalipoproteinemia (HP:0003563)2.88890203
57Leukocytosis (HP:0001974)2.87283828
58Vasculitis (HP:0002633)2.85693708
59Urticaria (HP:0001025)2.84873607
60Visual hallucinations (HP:0002367)2.84606085
61Encephalitis (HP:0002383)2.83237932
62Abnormality of T cells (HP:0002843)2.83118936
63Increased circulating renin level (HP:0000848)2.83022198
64Fat malabsorption (HP:0002630)2.79098537
65Chest pain (HP:0100749)2.77796753
66Hypokalemic alkalosis (HP:0001949)2.77681324
67Arterial thrombosis (HP:0004420)2.76989573
68Keratoconjunctivitis (HP:0001096)2.76301529
69Cellulitis (HP:0100658)2.73611470
70Abnormality of glycine metabolism (HP:0010895)2.72421869
71Abnormality of serine family amino acid metabolism (HP:0010894)2.72421869
72Mediastinal lymphadenopathy (HP:0100721)2.70545195
73Abnormality of the corticospinal tract (HP:0002492)2.70175249
74Abnormality of the fingertips (HP:0001211)2.68337751
75Chronic obstructive pulmonary disease (HP:0006510)2.67854859
76Obstructive lung disease (HP:0006536)2.67854859
77Inflammation of the large intestine (HP:0002037)2.66667785
78Abnormality of the intrinsic pathway (HP:0010989)2.65662190
79Subacute progressive viral hepatitis (HP:0006572)2.65355130
80Polycythemia (HP:0001901)2.63769052
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.62703870
82Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62145423
83Pustule (HP:0200039)2.61939087
84Hyperammonemia (HP:0001987)2.56497306
85Symptomatic seizures (HP:0011145)2.54184958
86Gastrointestinal inflammation (HP:0004386)2.53062069
87Abnormal gallbladder morphology (HP:0012437)2.50782657
88Acanthocytosis (HP:0001927)2.47594463
89Hyperbilirubinemia (HP:0002904)2.43366174
90Gout (HP:0001997)2.43318585
91Osteomyelitis (HP:0002754)2.42724640
92Intention tremor (HP:0002080)2.41178767
93Hyperglycinemia (HP:0002154)2.39454486
94Abnormality of purine metabolism (HP:0004352)2.39052981
95Abnormal platelet volume (HP:0011876)2.36951439
96Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.36711698
97Colitis (HP:0002583)2.36463895
98Viral hepatitis (HP:0006562)2.35046871
99Hypolipoproteinemia (HP:0010981)2.33268456
100Sensory axonal neuropathy (HP:0003390)2.33107606
101Skin nodule (HP:0200036)2.31412061
102Abnormality of fatty-acid metabolism (HP:0004359)2.30070248
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29401112
104Alkalosis (HP:0001948)2.28584476
105Abnormality of methionine metabolism (HP:0010901)2.27942965
106Hyperglycinuria (HP:0003108)2.27758178
107Cholelithiasis (HP:0001081)2.27320149
108Metabolic alkalosis (HP:0200114)2.26908860
109Recurrent bronchitis (HP:0002837)2.25029888
110Eosinophilia (HP:0001880)2.24522210
111Hemorrhage of the eye (HP:0011885)2.24082739
112Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.23984955
113Papillary thyroid carcinoma (HP:0002895)2.23800669
114Hypoalphalipoproteinemia (HP:0003233)2.23384045
115Granulocytopenia (HP:0001913)2.23304361
116Hemoptysis (HP:0002105)2.22548274
117Periodontitis (HP:0000704)2.22362682
118Turricephaly (HP:0000262)2.21194313
119Conjunctival telangiectasia (HP:0000524)2.19736766
120Anorexia (HP:0002039)2.18702990
121Joint hemorrhage (HP:0005261)2.18413639
122Pulmonary infiltrates (HP:0002113)2.17813226
123Hypochromic microcytic anemia (HP:0004840)2.15254196
124Orthostatic hypotension (HP:0001278)2.14257460
125Termporal pattern (HP:0011008)2.13371094
126Insidious onset (HP:0003587)2.13371094
127Episodic fever (HP:0001954)2.13346242
128Poikilocytosis (HP:0004447)2.12959209
129Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12111105
130Hypophosphatemic rickets (HP:0004912)2.11854038
131Protuberant abdomen (HP:0001538)2.11850151
132Pulmonary embolism (HP:0002204)2.11384549
133Rickets (HP:0002748)2.09069708
134Resting tremor (HP:0002322)2.08873444
135Acute hepatic failure (HP:0006554)2.06058715
136Pancreatic islet-cell hyperplasia (HP:0004510)2.05757695
137Abnormality of the peritoneum (HP:0002585)2.05132479
138Delayed CNS myelination (HP:0002188)2.03405868
139Hypoplasia of the thymus (HP:0000778)2.03293974
140Autoimmune hemolytic anemia (HP:0001890)2.02747669
141Ileus (HP:0002595)2.02427777
142Increased mean platelet volume (HP:0011877)2.01602439
143Difficulty running (HP:0009046)2.01361382
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00964276
145Onion bulb formation (HP:0003383)2.00743671
146Hepatocellular carcinoma (HP:0001402)2.00485383
147Cerebral hemorrhage (HP:0001342)1.99889716
148Back pain (HP:0003418)1.99128912
149Supranuclear gaze palsy (HP:0000605)1.98938492
150Steatorrhea (HP:0002570)1.98269102
151Hyperactive renin-angiotensin system (HP:0000841)1.96438843
152Abnormality of eosinophils (HP:0001879)1.96177362
153Abnormality of endocrine pancreas physiology (HP:0012093)1.95204171
154Abnormality of the pancreatic islet cells (HP:0006476)1.95204171
155Abnormality of complement system (HP:0005339)1.95181225
156Toxemia of pregnancy (HP:0100603)1.94672079
157Hypercholesterolemia (HP:0003124)1.94458935
158Abnormality of proline metabolism (HP:0010907)1.94405700
159Hydroxyprolinuria (HP:0003080)1.94405700
160Panhypogammaglobulinemia (HP:0003139)1.94305737
161Hyperglycemia (HP:0003074)1.94194043
162Irritability (HP:0000737)1.93739650
163Lymphopenia (HP:0001888)1.92626570
164Vascular calcification (HP:0004934)1.92490826
165Verrucae (HP:0200043)1.91542989
166Papilloma (HP:0012740)1.91542989
167Metabolic acidosis (HP:0001942)1.90755188
168Abnormality of renin-angiotensin system (HP:0000847)1.89220772
169Abnormal gallbladder physiology (HP:0012438)1.88861092
170Cholecystitis (HP:0001082)1.88861092
171Abnormality of the gallbladder (HP:0005264)1.87700225
172Amyloidosis (HP:0011034)1.87584492
173Menorrhagia (HP:0000132)1.87226456
174Enlarged kidneys (HP:0000105)1.86244215
175Spastic gait (HP:0002064)1.85347492
176Hypomagnesemia (HP:0002917)1.85343447
177Abnormality of cells of the lymphoid lineage (HP:0012140)1.82164553
178Pheochromocytoma (HP:0002666)1.82075590
179Peripheral demyelination (HP:0011096)1.81424412
180Increased IgE level (HP:0003212)1.80438856
181Axonal loss (HP:0003447)1.80277770
182Spastic paraparesis (HP:0002313)1.80262545
183Hematochezia (HP:0002573)1.79472067
184Fatigue (HP:0012378)1.79320323
185Generalized aminoaciduria (HP:0002909)1.78528622
186Abnormality of T cell physiology (HP:0011840)1.78334934
187Hypokalemia (HP:0002900)1.77571471
188Thrombophlebitis (HP:0004418)1.76246449
189Cardiovascular calcification (HP:0011915)1.76152309
190Neoplasm of the tracheobronchial system (HP:0100552)1.76101690
191Akinesia (HP:0002304)1.75785617
192IgM deficiency (HP:0002850)1.71099805
193Acne (HP:0001061)1.66811766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.46595215
2RIPK43.99176039
3EPHB13.42898664
4WNK43.26432530
5OXSR13.19354874
6MAP2K33.14754278
7GRK63.12691608
8INSRR2.96978798
9BLK2.63445376
10MAP4K12.44629868
11FGFR22.39449223
12MET2.35925751
13IKBKE2.17410024
14SIK12.12467005
15CSK2.10124848
16PRPF4B2.08912032
17TAOK32.03013922
18BCKDK2.02684654
19TAOK12.01095692
20MAP3K21.99442099
21TYK21.93244722
22SGK21.91307766
23NTRK11.90415768
24FES1.90388979
25PTK2B1.90383293
26ICK1.86401517
27SYK1.80736867
28IRAK41.80684964
29JAK31.77724255
30MAP3K31.74869025
31PKN11.72554203
32STK41.69964958
33WNK11.63939363
34TRIB31.56639917
35BTK1.56438669
36BCR1.54183590
37FGFR31.51719396
38ZAP701.46171993
39PAK31.44119231
40UHMK11.42097571
41LATS11.41565896
42GRK51.40049065
43SGK4941.40043119
44SGK2231.40043119
45TXK1.38901774
46FGFR41.37627825
47HCK1.37422120
48ERBB41.36914088
49MAP3K111.35842830
50WNK31.32152959
51PIM11.28911860
52TYRO31.28037909
53PTK21.27077571
54MAP3K141.25477485
55JAK11.25179798
56ERN11.24623383
57MAPK151.24269078
58FRK1.22757837
59YES11.20026221
60IRAK21.19551711
61CAMK1G1.19202204
62TAOK21.18631728
63PTK61.17597316
64MARK11.16052874
65MAP3K131.15219932
66MARK31.14975680
67PDGFRA1.14543830
68BMPR21.11985207
69RET1.09160572
70LYN1.08004504
71TRPM71.07941968
72CAMK1D1.07891435
73CSNK1A1L1.05596127
74ITK1.03521088
75MST1R1.01841700
76NLK1.01794395
77CDK121.01732207
78MAP3K101.00339960
79TNK20.99305527
80TNIK0.98112723
81TEC0.97765462
82PAK60.94303148
83GSK3A0.89937825
84LCK0.88586165
85MAP3K60.88386640
86PLK20.88318500
87KSR20.87357377
88CSNK1G20.86967048
89CSNK1G30.85141094
90IRAK10.84907594
91KSR10.83690653
92PRKCH0.82931082
93MAP2K20.82927054
94MAPKAPK50.81641437
95PRKD30.81625396
96PBK0.81454496
97STK380.81316452
98FGR0.80957798
99DDR20.80394532
100MAP3K50.80246218
101CSNK1G10.80053711
102PDGFRB0.80035245
103PHKG20.78757752
104PHKG10.78757752
105PRKD10.78501982
106BMX0.77700843
107STK110.76616194
108PKN20.75941882
109PDK10.75778721
110LRRK20.75070677
111CAMKK20.74648568
112DYRK1A0.74553835
113CAMK2B0.73892329
114CAMK2D0.73177248
115RIPK10.71604684
116PDPK10.71490287
117MATK0.70431473
118HIPK20.70302811
119EIF2AK10.68619158
120ROCK20.67114310
121DYRK1B0.66962476
122IKBKB0.66661897
123ERBB20.66422410
124MAP3K70.65692643
125ACVR1B0.65283862
126LIMK10.63779849
127MAP3K10.63725227
128DAPK20.63662942
129CDK50.62960315
130PIK3CG0.62331433
131ABL20.61662994
132ROCK10.60956182
133RAF10.60687695
134TBK10.60467963
135CSF1R0.60168947
136PRKAA10.59876498
137CAMK2G0.59138781
138MAP2K40.58544661
139JAK20.56786371
140MARK20.56738175
141PRKAA20.56335261
142MAP2K10.55755974
143SCYL20.55172324
144NEK60.55015650
145FER0.54275024
146STK100.52519571
147DMPK0.50678907
148CAMK40.50173829
149LMTK20.47927647
150PRKCQ0.47916784
151PRKACG0.47856391
152FYN0.47222974
153PRKCZ0.46795598
154MAPK120.46683565
155PRKCE0.45342161
156AKT30.45269778
157CHUK0.45023235
158TGFBR20.43179916
159KIT0.42677419
160CAMK2A0.42265184
161SGK30.41978454
162TIE10.41381211
163SGK10.38110203
164EPHA30.38048496
165MST40.36673598
166FGFR10.36024396
167CDC42BPA0.35505607

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.13310605
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.81238398
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72493630
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71735253
5B cell receptor signaling pathway_Homo sapiens_hsa046622.63536552
6Butanoate metabolism_Homo sapiens_hsa006502.55582238
7Steroid biosynthesis_Homo sapiens_hsa001002.55092298
8Sulfur metabolism_Homo sapiens_hsa009202.52397183
9Leishmaniasis_Homo sapiens_hsa051402.43894868
10Osteoclast differentiation_Homo sapiens_hsa043802.36366547
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36080733
12Non-small cell lung cancer_Homo sapiens_hsa052232.30137886
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.29205102
14Fatty acid elongation_Homo sapiens_hsa000622.26386102
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19181400
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.16205719
17Fatty acid degradation_Homo sapiens_hsa000712.14772294
18Tryptophan metabolism_Homo sapiens_hsa003802.10506430
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.00785134
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00741154
21Fatty acid metabolism_Homo sapiens_hsa012121.99234726
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.95651324
23Propanoate metabolism_Homo sapiens_hsa006401.94803134
24T cell receptor signaling pathway_Homo sapiens_hsa046601.94388318
25Arginine biosynthesis_Homo sapiens_hsa002201.93434521
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89802105
27Acute myeloid leukemia_Homo sapiens_hsa052211.81800067
28Malaria_Homo sapiens_hsa051441.78874116
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78852917
30Peroxisome_Homo sapiens_hsa041461.74369848
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73968426
32Histidine metabolism_Homo sapiens_hsa003401.70289281
33Tuberculosis_Homo sapiens_hsa051521.67469243
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65266379
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.61954664
36Complement and coagulation cascades_Homo sapiens_hsa046101.59965393
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59945462
38Primary immunodeficiency_Homo sapiens_hsa053401.59665877
39Measles_Homo sapiens_hsa051621.59125654
40PPAR signaling pathway_Homo sapiens_hsa033201.59048023
41Pancreatic cancer_Homo sapiens_hsa052121.58625437
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54519045
43Chemokine signaling pathway_Homo sapiens_hsa040621.54494042
44Chronic myeloid leukemia_Homo sapiens_hsa052201.53507620
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52960318
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.49999924
47Platelet activation_Homo sapiens_hsa046111.48648492
48Bile secretion_Homo sapiens_hsa049761.44084696
49Endometrial cancer_Homo sapiens_hsa052131.40100459
50FoxO signaling pathway_Homo sapiens_hsa040681.38425314
51Toxoplasmosis_Homo sapiens_hsa051451.38349061
52Prolactin signaling pathway_Homo sapiens_hsa049171.37782518
53Hematopoietic cell lineage_Homo sapiens_hsa046401.36234747
54beta-Alanine metabolism_Homo sapiens_hsa004101.35194942
55Influenza A_Homo sapiens_hsa051641.32654534
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32606774
57Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32526320
58Fat digestion and absorption_Homo sapiens_hsa049751.30113174
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.27669706
60Hepatitis B_Homo sapiens_hsa051611.26841897
61ABC transporters_Homo sapiens_hsa020101.26115636
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24724859
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24717384
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24066087
65Inositol phosphate metabolism_Homo sapiens_hsa005621.23067666
66Leukocyte transendothelial migration_Homo sapiens_hsa046701.22567580
67Graft-versus-host disease_Homo sapiens_hsa053321.22114420
68VEGF signaling pathway_Homo sapiens_hsa043701.21659198
69Hepatitis C_Homo sapiens_hsa051601.18622356
70Allograft rejection_Homo sapiens_hsa053301.16244909
71Pyruvate metabolism_Homo sapiens_hsa006201.15714728
72Neurotrophin signaling pathway_Homo sapiens_hsa047221.14437052
73Caffeine metabolism_Homo sapiens_hsa002321.14022349
74mTOR signaling pathway_Homo sapiens_hsa041501.13299734
75Chemical carcinogenesis_Homo sapiens_hsa052041.11373482
76Autoimmune thyroid disease_Homo sapiens_hsa053201.10502804
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10073591
78TNF signaling pathway_Homo sapiens_hsa046681.09789986
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09450660
80Apoptosis_Homo sapiens_hsa042101.08248898
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07981272
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07205786
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05328525
84Selenocompound metabolism_Homo sapiens_hsa004501.01747961
85Vitamin B6 metabolism_Homo sapiens_hsa007501.01396747
86Phenylalanine metabolism_Homo sapiens_hsa003601.01343936
87Tyrosine metabolism_Homo sapiens_hsa003501.00369132
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98914938
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98886247
90Legionellosis_Homo sapiens_hsa051340.98416282
91Herpes simplex infection_Homo sapiens_hsa051680.98283667
92Starch and sucrose metabolism_Homo sapiens_hsa005000.95780003
93Retinol metabolism_Homo sapiens_hsa008300.95625018
94Arginine and proline metabolism_Homo sapiens_hsa003300.95027726
95African trypanosomiasis_Homo sapiens_hsa051430.93201058
96Glioma_Homo sapiens_hsa052140.92590668
97Choline metabolism in cancer_Homo sapiens_hsa052310.92364796
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88957014
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85670578
100Notch signaling pathway_Homo sapiens_hsa043300.85414530
101Ether lipid metabolism_Homo sapiens_hsa005650.85304996
102Prostate cancer_Homo sapiens_hsa052150.85251736
103ErbB signaling pathway_Homo sapiens_hsa040120.83592516
104Fatty acid biosynthesis_Homo sapiens_hsa000610.82883200
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81749515
106Type I diabetes mellitus_Homo sapiens_hsa049400.80676607
107Staphylococcus aureus infection_Homo sapiens_hsa051500.80522984
108Long-term potentiation_Homo sapiens_hsa047200.80115264
109Glycerolipid metabolism_Homo sapiens_hsa005610.79487938
110GnRH signaling pathway_Homo sapiens_hsa049120.79004795
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76723191
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.76696343
113Vitamin digestion and absorption_Homo sapiens_hsa049770.76500956
114Regulation of autophagy_Homo sapiens_hsa041400.76237496
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75316500
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.74818936
117Folate biosynthesis_Homo sapiens_hsa007900.74678881
118Phagosome_Homo sapiens_hsa041450.73262732
119HIF-1 signaling pathway_Homo sapiens_hsa040660.72648678
120Lysine degradation_Homo sapiens_hsa003100.71927323
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68800646
122Antigen processing and presentation_Homo sapiens_hsa046120.68685615
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67438674
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66756320
125Thyroid cancer_Homo sapiens_hsa052160.66755037
126Colorectal cancer_Homo sapiens_hsa052100.65428236
127Viral myocarditis_Homo sapiens_hsa054160.63984714
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63857422
129Viral carcinogenesis_Homo sapiens_hsa052030.62047566
130Lysosome_Homo sapiens_hsa041420.59605424
131Glutathione metabolism_Homo sapiens_hsa004800.59199880
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.58297227
133Carbon metabolism_Homo sapiens_hsa012000.57870931
134MAPK signaling pathway_Homo sapiens_hsa040100.57826082
135Small cell lung cancer_Homo sapiens_hsa052220.56549764
136Endocytosis_Homo sapiens_hsa041440.54808141
137Type II diabetes mellitus_Homo sapiens_hsa049300.54572474
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54149279
139HTLV-I infection_Homo sapiens_hsa051660.53203733
140Linoleic acid metabolism_Homo sapiens_hsa005910.52090928
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51472206
142Prion diseases_Homo sapiens_hsa050200.50625645
143Insulin signaling pathway_Homo sapiens_hsa049100.50360822
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50021227
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.49613948
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48896500
147Shigellosis_Homo sapiens_hsa051310.48744324
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47792806
149Protein digestion and absorption_Homo sapiens_hsa049740.47689217
150Estrogen signaling pathway_Homo sapiens_hsa049150.47043514
151Protein export_Homo sapiens_hsa030600.47019134
152Thyroid hormone synthesis_Homo sapiens_hsa049180.46021317
153Insulin resistance_Homo sapiens_hsa049310.45931159
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45108045
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45048978
156Insulin secretion_Homo sapiens_hsa049110.43703706
157Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43307084
158Amoebiasis_Homo sapiens_hsa051460.43105743
159Pertussis_Homo sapiens_hsa051330.43015544
160Adipocytokine signaling pathway_Homo sapiens_hsa049200.42750248
161Rap1 signaling pathway_Homo sapiens_hsa040150.42645812
162Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42577580
163Biosynthesis of amino acids_Homo sapiens_hsa012300.42535719
164Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40617896
165Pancreatic secretion_Homo sapiens_hsa049720.39871971
166Cysteine and methionine metabolism_Homo sapiens_hsa002700.39609623
167Sphingolipid metabolism_Homo sapiens_hsa006000.38962101
168Mineral absorption_Homo sapiens_hsa049780.38552698
169Axon guidance_Homo sapiens_hsa043600.38159829
170Ovarian steroidogenesis_Homo sapiens_hsa049130.36359314
171Sulfur relay system_Homo sapiens_hsa041220.35571585
172Glycerophospholipid metabolism_Homo sapiens_hsa005640.35293533
173Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34876755
174AMPK signaling pathway_Homo sapiens_hsa041520.34451300
175Metabolic pathways_Homo sapiens_hsa011000.30511304
176Cyanoamino acid metabolism_Homo sapiens_hsa004600.26721212
177Vibrio cholerae infection_Homo sapiens_hsa051100.26678042
178Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25760960
179GABAergic synapse_Homo sapiens_hsa047270.25582563
180Collecting duct acid secretion_Homo sapiens_hsa049660.25097658
181Cocaine addiction_Homo sapiens_hsa050300.23894197
182Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23610414
183Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23602953
184Renal cell carcinoma_Homo sapiens_hsa052110.23216390
185Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21103750
186ECM-receptor interaction_Homo sapiens_hsa045120.20538904
187Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19851727
188Dorso-ventral axis formation_Homo sapiens_hsa043200.17481281

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