MARCKS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.02983793
2somite development (GO:0061053)4.25967789
3limb bud formation (GO:0060174)4.05074678
4kinetochore assembly (GO:0051382)4.04777273
5kinetochore organization (GO:0051383)4.00051460
6presynaptic membrane assembly (GO:0097105)3.98969795
7Rap protein signal transduction (GO:0032486)3.90407638
8dermatan sulfate biosynthetic process (GO:0030208)3.88834932
9activated T cell proliferation (GO:0050798)3.84842087
10negative regulation of axon extension involved in axon guidance (GO:0048843)3.82852563
11negative regulation of axon extension (GO:0030517)3.82834821
12negative regulation of axon guidance (GO:1902668)3.81781754
13locomotory exploration behavior (GO:0035641)3.79987219
14DNA double-strand break processing (GO:0000729)3.76349314
15axonal fasciculation (GO:0007413)3.75367825
16replication fork processing (GO:0031297)3.70559607
17neuron recognition (GO:0008038)3.67033956
18atrial cardiac muscle cell action potential (GO:0086014)3.66741837
19semaphorin-plexin signaling pathway (GO:0071526)3.65871958
20neural tube formation (GO:0001841)3.64479982
21positive regulation of actin filament depolymerization (GO:0030836)3.59683610
22dermatan sulfate metabolic process (GO:0030205)3.57968545
23cerebral cortex radially oriented cell migration (GO:0021799)3.52733435
24kidney morphogenesis (GO:0060993)3.43904389
25microtubule depolymerization (GO:0007019)3.43522513
26regulation of development, heterochronic (GO:0040034)3.41725060
27pyrimidine nucleobase catabolic process (GO:0006208)3.37523582
28dendrite morphogenesis (GO:0048813)3.32536544
29presynaptic membrane organization (GO:0097090)3.29393408
30otic vesicle formation (GO:0030916)3.27914716
31postsynaptic membrane organization (GO:0001941)3.27195662
32cornea development in camera-type eye (GO:0061303)3.26080388
33peripheral nervous system axon ensheathment (GO:0032292)3.26033822
34myelination in peripheral nervous system (GO:0022011)3.26033822
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.22371246
36maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.21133799
37dendritic spine morphogenesis (GO:0060997)3.20348105
38intraciliary transport (GO:0042073)3.19406650
39positive regulation of synapse assembly (GO:0051965)3.18944134
40response to pheromone (GO:0019236)3.16885862
41neuron fate determination (GO:0048664)3.16238775
42regulation of axon guidance (GO:1902667)3.13416998
43metanephric mesenchyme development (GO:0072075)3.12019952
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11700292
45regulation of axon extension involved in axon guidance (GO:0048841)3.04944183
46resolution of meiotic recombination intermediates (GO:0000712)3.04929025
47glycosphingolipid biosynthetic process (GO:0006688)3.02423498
48lateral sprouting from an epithelium (GO:0060601)3.00690105
49kidney mesenchyme development (GO:0072074)3.00328117
50histone H2A acetylation (GO:0043968)2.99937529
51neurotransmitter-gated ion channel clustering (GO:0072578)2.98510255
52cellular response to cholesterol (GO:0071397)2.95944656
53exploration behavior (GO:0035640)2.95587014
54forebrain neuron differentiation (GO:0021879)2.92534293
55limb development (GO:0060173)2.90369642
56appendage development (GO:0048736)2.90369642
57metaphase plate congression (GO:0051310)2.89611885
58central nervous system projection neuron axonogenesis (GO:0021952)2.88161495
59regulation of collateral sprouting (GO:0048670)2.88010914
60negative regulation of transcription regulatory region DNA binding (GO:2000678)2.86441726
61cell differentiation involved in kidney development (GO:0061005)2.86177099
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84949429
63cellular response to hepatocyte growth factor stimulus (GO:0035729)2.83823864
64response to hepatocyte growth factor (GO:0035728)2.83823864
65keratinocyte development (GO:0003334)2.83200739
66platelet dense granule organization (GO:0060155)2.82051263
67hindbrain development (GO:0030902)2.80717689
68L-amino acid import (GO:0043092)2.79625980
69amino acid import (GO:0043090)2.79395010
70mechanosensory behavior (GO:0007638)2.78740433
71nonmotile primary cilium assembly (GO:0035058)2.78489967
72microtubule polymerization or depolymerization (GO:0031109)2.77467693
73cellular response to sterol (GO:0036315)2.75886855
74negative regulation of axonogenesis (GO:0050771)2.74634390
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70664339
76transmission of nerve impulse (GO:0019226)2.69981455
77chondroitin sulfate catabolic process (GO:0030207)2.68798788
78regulation of neuron migration (GO:2001222)2.66250771
79regulation of telomere maintenance (GO:0032204)2.65611439
80cilium morphogenesis (GO:0060271)2.64497789
81negative regulation of astrocyte differentiation (GO:0048712)2.64100537
82negative regulation of neurotransmitter secretion (GO:0046929)2.64058528
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63902035
84negative chemotaxis (GO:0050919)2.63058682
85cranial nerve morphogenesis (GO:0021602)2.62573974
86regulation of activation of Janus kinase activity (GO:0010533)2.62027017
87mesenchymal cell differentiation involved in renal system development (GO:2001012)2.59764316
88mesenchymal cell differentiation involved in kidney development (GO:0072161)2.59764316
89regulation of translation, ncRNA-mediated (GO:0045974)2.59446286
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.59446286
91negative regulation of translation, ncRNA-mediated (GO:0040033)2.59446286
92positive regulation of protein autophosphorylation (GO:0031954)2.59436706
93cilium assembly (GO:0042384)2.58906866
94positive regulation of neurological system process (GO:0031646)2.57493264
95positive regulation of amino acid transport (GO:0051957)2.57119656
96cilium organization (GO:0044782)2.56831842
97sympathetic nervous system development (GO:0048485)2.56041422
98auditory behavior (GO:0031223)2.54944712
99positive regulation of neuroblast proliferation (GO:0002052)2.54035409
100regulation of transmission of nerve impulse (GO:0051969)2.53427471
101oligodendrocyte differentiation (GO:0048709)2.52960156
102negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.52912718
103positive regulation of cardiac muscle tissue growth (GO:0055023)2.52789069
104inner ear receptor stereocilium organization (GO:0060122)2.52404260
105regulation of dendritic cell antigen processing and presentation (GO:0002604)2.52400001
106positive regulation of smooth muscle cell migration (GO:0014911)2.51017645
107mitotic sister chromatid cohesion (GO:0007064)2.50106316
108positive regulation of protein depolymerization (GO:1901881)2.49204366
109substantia nigra development (GO:0021762)2.48946779
110ventricular cardiac muscle cell development (GO:0055015)2.48475490
111positive regulation of heart growth (GO:0060421)2.48425724
112positive regulation of catenin import into nucleus (GO:0035413)2.47832012
113embryonic digestive tract morphogenesis (GO:0048557)2.47521692
114dorsal/ventral axis specification (GO:0009950)2.47176298
115regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47152009
116spinal cord development (GO:0021510)2.46989861
117negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.46184801
118axon extension (GO:0048675)2.45811833
119regulation of synapse assembly (GO:0051963)2.45514324
120response to prostaglandin E (GO:0034695)2.45354873
121cardiac ventricle formation (GO:0003211)2.45217315
122epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.44951563
123centriole replication (GO:0007099)2.43740188
124establishment of nucleus localization (GO:0040023)2.42900148
125regulation of extent of cell growth (GO:0061387)2.42820685
126nucleobase catabolic process (GO:0046113)2.42814517
127ganglion development (GO:0061548)2.42439212
128cerebral cortex cell migration (GO:0021795)2.42237287
129myelination (GO:0042552)2.41701127
130gamma-aminobutyric acid transport (GO:0015812)2.41361754
131olfactory bulb development (GO:0021772)2.41235995
132response to lipoprotein particle (GO:0055094)2.41094602
133regulation of keratinocyte proliferation (GO:0010837)2.41048174
134cerebellar granule cell differentiation (GO:0021707)2.40897438
135membrane assembly (GO:0071709)2.40828207
136positive regulation of T-helper cell differentiation (GO:0045624)2.39555086
137startle response (GO:0001964)2.38360285
138chondrocyte development (GO:0002063)2.37960582
139positive regulation of cardiac muscle cell differentiation (GO:2000727)2.37866089
140C4-dicarboxylate transport (GO:0015740)2.37693271
141glomerulus development (GO:0032835)2.37606860
142positive regulation of cardiac muscle cell proliferation (GO:0060045)2.36376981
143artery development (GO:0060840)2.35973657
144calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.34665492
145retinal ganglion cell axon guidance (GO:0031290)2.34361712
146regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.33945569
147axon ensheathment (GO:0008366)2.33236857
148ensheathment of neurons (GO:0007272)2.33236857
149negative regulation of oligodendrocyte differentiation (GO:0048715)2.32913220
150negative regulation of developmental growth (GO:0048640)2.30373967
151central nervous system neuron axonogenesis (GO:0021955)2.30197373
152cellular response to prostaglandin stimulus (GO:0071379)2.27842358
153vocalization behavior (GO:0071625)2.27149169
154negative regulation of stem cell proliferation (GO:2000647)2.26048863
155regulation of T-helper 2 cell differentiation (GO:0045628)2.25142934
156neuronal ion channel clustering (GO:0045161)2.24560856
157regulation of axon extension (GO:0030516)2.24157736
158cell differentiation involved in metanephros development (GO:0072202)2.23379454
159negative regulation of myoblast differentiation (GO:0045662)2.23251745
160neuron migration (GO:0001764)2.22672986
161regulation of T-helper 1 cell differentiation (GO:0045625)2.19670362
162dendrite development (GO:0016358)2.19413116
163regulation of oligodendrocyte differentiation (GO:0048713)2.18390035
164glial cell proliferation (GO:0014009)2.17085306
165regulation of glomerulus development (GO:0090192)2.16529681
166regulation of timing of cell differentiation (GO:0048505)2.16085295
167axon ensheathment in central nervous system (GO:0032291)2.16044873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.01655627
2GBX2_23144817_ChIP-Seq_PC3_Human2.97278601
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.69890842
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67643075
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59916565
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.59762569
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.53839642
8* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46107225
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44858498
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43345234
11AR_21572438_ChIP-Seq_LNCaP_Human2.39934975
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36485229
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36292393
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36292393
15* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.23712706
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23407365
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22961141
18* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.14544462
19SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.06882795
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04601947
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04482264
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00410054
23* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90243712
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88253249
25TAF15_26573619_Chip-Seq_HEK293_Human1.88249811
26* P300_19829295_ChIP-Seq_ESCs_Human1.87287450
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82482125
28* EZH2_27294783_Chip-Seq_ESCs_Mouse1.82471622
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80777980
30* WT1_19549856_ChIP-ChIP_CCG9911_Human1.77472405
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74944708
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74232883
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73690056
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73568841
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72771987
36* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72751592
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67938473
38* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67497979
39RNF2_27304074_Chip-Seq_NSC_Mouse1.64936166
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.64578663
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.62604986
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61631768
43FUS_26573619_Chip-Seq_HEK293_Human1.61464573
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59882267
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59551232
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.58965382
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58198253
48ER_23166858_ChIP-Seq_MCF-7_Human1.57382771
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.55958065
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.55397243
51TP53_18474530_ChIP-ChIP_U2OS_Human1.55050432
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53550120
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53542845
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53540801
55* BCAT_22108803_ChIP-Seq_LS180_Human1.52117899
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50711500
57* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50552658
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47693144
59* RING1B_27294783_Chip-Seq_NPCs_Mouse1.44898277
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43800566
61SMAD4_21799915_ChIP-Seq_A2780_Human1.43449785
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42423897
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42298525
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.41871061
65* EZH2_27294783_Chip-Seq_NPCs_Mouse1.40836362
66* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40094744
67* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40094744
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38949173
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36891493
70* STAT3_23295773_ChIP-Seq_U87_Human1.35524028
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.34181819
72AHR_22903824_ChIP-Seq_MCF-7_Human1.32815077
73VDR_22108803_ChIP-Seq_LS180_Human1.31624707
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31347439
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28379319
76CBP_20019798_ChIP-Seq_JUKART_Human1.28379319
77* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27809840
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27710357
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26924862
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.26053021
81TCF4_23295773_ChIP-Seq_U87_Human1.25249513
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.23997727
83DROSHA_22980978_ChIP-Seq_HELA_Human1.23906067
84* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23423709
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20752375
86P53_22387025_ChIP-Seq_ESCs_Mouse1.20615424
87* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19890170
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19764306
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19266640
90* EWS_26573619_Chip-Seq_HEK293_Human1.18644626
91* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18565734
92* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18565734
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.18421700
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.18155843
95* FLI1_21867929_ChIP-Seq_TH2_Mouse1.17979857
96TCF4_22108803_ChIP-Seq_LS180_Human1.17901779
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17807346
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17599100
99IGF1R_20145208_ChIP-Seq_DFB_Human1.17329918
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.16838689
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15486360
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.15211958
103* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15095028
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14211665
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.14158842
106* VDR_24787735_ChIP-Seq_THP-1_Human1.13776910
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13737902
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.13658076
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13223714
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11268490
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10895211
112AR_25329375_ChIP-Seq_VCAP_Human1.10859079
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09337944
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08535017
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07431410
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.07225834
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06888922
118KDM2B_26808549_Chip-Seq_REH_Human1.06778314
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06661936
120* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05963303
121* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05122287
122* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05062714
123JUN_21703547_ChIP-Seq_K562_Human1.04747164
124TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04420237
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04406897
126TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04338318
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.04097119
128* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03875045
129* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03566369
130NANOG_19829295_ChIP-Seq_ESCs_Human1.02925980
131SOX9_26525672_Chip-Seq_HEART_Mouse1.02521674
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.02049141
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01294258
134ZNF274_21170338_ChIP-Seq_K562_Hela1.01194571
135* REST_21632747_ChIP-Seq_MESCs_Mouse1.00710498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.03340470
2MP0006292_abnormal_olfactory_placode3.02660158
3* MP0000778_abnormal_nervous_system2.98794516
4MP0005171_absent_coat_pigmentation2.94177643
5MP0008438_abnormal_cutaneous_collagen2.50670319
6MP0006054_spinal_hemorrhage2.48892809
7MP0005623_abnormal_meninges_morphology2.45325511
8MP0002163_abnormal_gland_morphology2.37138369
9MP0004742_abnormal_vestibular_system2.21086960
10MP0005503_abnormal_tendon_morphology2.17176056
11* MP0003385_abnormal_body_wall2.06720314
12MP0003122_maternal_imprinting2.04442912
13MP0005423_abnormal_somatic_nervous2.03591367
14MP0009250_abnormal_appendicular_skeleto2.02174504
15MP0004134_abnormal_chest_morphology2.00149930
16MP0005253_abnormal_eye_physiology1.80977583
17MP0003787_abnormal_imprinting1.78737507
18MP0001529_abnormal_vocalization1.78444261
19MP0001346_abnormal_lacrimal_gland1.76521636
20MP0006072_abnormal_retinal_apoptosis1.76339705
21MP0000569_abnormal_digit_pigmentation1.76263202
22MP0003136_yellow_coat_color1.68874632
23MP0002234_abnormal_pharynx_morphology1.68384304
24MP0004272_abnormal_basement_membrane1.68185202
25MP0004858_abnormal_nervous_system1.65455407
26MP0002638_abnormal_pupillary_reflex1.61402165
27MP0002102_abnormal_ear_morphology1.61386009
28MP0002282_abnormal_trachea_morphology1.61253494
29MP0003938_abnormal_ear_development1.61123198
30MP0002938_white_spotting1.60649831
31MP0003890_abnormal_embryonic-extraembry1.60188437
32MP0008789_abnormal_olfactory_epithelium1.57151785
33MP0009053_abnormal_anal_canal1.55388211
34MP0001348_abnormal_lacrimal_gland1.53758850
35MP0000920_abnormal_myelination1.52337779
36MP0005551_abnormal_eye_electrophysiolog1.51884462
37MP0002184_abnormal_innervation1.50266342
38MP0000049_abnormal_middle_ear1.49823906
39MP0000372_irregular_coat_pigmentation1.47202138
40MP0003937_abnormal_limbs/digits/tail_de1.45938463
41MP0002653_abnormal_ependyma_morphology1.45496242
42MP0000537_abnormal_urethra_morphology1.44355381
43MP0002277_abnormal_respiratory_mucosa1.43380573
44MP0003942_abnormal_urinary_system1.42974133
45MP0001984_abnormal_olfaction1.42417461
46MP0001486_abnormal_startle_reflex1.42202457
47MP0001293_anophthalmia1.38748329
48MP0003690_abnormal_glial_cell1.38479361
49MP0004133_heterotaxia1.36765046
50MP0003755_abnormal_palate_morphology1.36093921
51MP0005367_renal/urinary_system_phenotyp1.35397190
52MP0000516_abnormal_urinary_system1.35397190
53MP0005187_abnormal_penis_morphology1.35336567
54MP0000647_abnormal_sebaceous_gland1.35063231
55MP0008877_abnormal_DNA_methylation1.34024981
56MP0004885_abnormal_endolymph1.33780475
57MP0001299_abnormal_eye_distance/1.33289036
58MP0003635_abnormal_synaptic_transmissio1.31265182
59MP0003121_genomic_imprinting1.29921621
60MP0002751_abnormal_autonomic_nervous1.29753165
61MP0002063_abnormal_learning/memory/cond1.26048092
62MP0005257_abnormal_intraocular_pressure1.25487671
63MP0003195_calcinosis1.24826055
64MP0005174_abnormal_tail_pigmentation1.24732512
65MP0006276_abnormal_autonomic_nervous1.23728616
66MP0005379_endocrine/exocrine_gland_phen1.23619432
67MP0003634_abnormal_glial_cell1.23077384
68MP0000534_abnormal_ureter_morphology1.23056494
69MP0001177_atelectasis1.22116023
70MP0005391_vision/eye_phenotype1.20875319
71MP0003941_abnormal_skin_development1.20864016
72MP0000566_synostosis1.17939660
73MP0003119_abnormal_digestive_system1.16045774
74MP0000631_abnormal_neuroendocrine_gland1.14931558
75MP0001485_abnormal_pinna_reflex1.14634420
76MP0002009_preneoplasia1.13082775
77MP0005248_abnormal_Harderian_gland1.12896548
78MP0002882_abnormal_neuron_morphology1.12871609
79MP0005645_abnormal_hypothalamus_physiol1.12448185
80MP0000026_abnormal_inner_ear1.11732198
81MP0005499_abnormal_olfactory_system1.11268841
82MP0005394_taste/olfaction_phenotype1.11268841
83MP0003861_abnormal_nervous_system1.10948084
84MP0002572_abnormal_emotion/affect_behav1.10630945
85MP0009745_abnormal_behavioral_response1.09894430
86MP0002735_abnormal_chemical_nociception1.09881046
87MP0002064_seizures1.09152508
88MP0002233_abnormal_nose_morphology1.08684564
89MP0002557_abnormal_social/conspecific_i1.07969117
90MP0005275_abnormal_skin_tensile1.07832120
91MP0001879_abnormal_lymphatic_vessel1.07794158
92MP0002295_abnormal_pulmonary_circulatio1.07229804
93* MP0005195_abnormal_posterior_eye1.07124221
94MP0002837_dystrophic_cardiac_calcinosis1.07043566
95MP0003567_abnormal_fetal_cardiomyocyte1.05994342
96MP0005386_behavior/neurological_phenoty1.05040264
97MP0004924_abnormal_behavior1.05040264
98MP0001188_hyperpigmentation1.03810082
99* MP0002116_abnormal_craniofacial_bone1.03631505
100MP0009384_cardiac_valve_regurgitation1.03304552
101MP0004510_myositis1.03184251
102MP0001968_abnormal_touch/_nociception1.02957703
103MP0002177_abnormal_outer_ear1.02707989
104MP0002152_abnormal_brain_morphology1.00946607
105MP0002148_abnormal_hypersensitivity_rea0.99975491
106MP0002067_abnormal_sensory_capabilities0.99262082
107MP0000955_abnormal_spinal_cord0.99218907
108MP0009046_muscle_twitch0.99102171
109MP0004270_analgesia0.93782602
110MP0002752_abnormal_somatic_nervous0.93604364
111MP0000428_abnormal_craniofacial_morphol0.93292861
112MP0000462_abnormal_digestive_system0.92152733
113MP0002734_abnormal_mechanical_nocicepti0.91482174
114MP0010094_abnormal_chromosome_stability0.91353159
115MP0003115_abnormal_respiratory_system0.90393035
116MP0001324_abnormal_eye_pigmentation0.89659382
117MP0004859_abnormal_synaptic_plasticity0.89502616
118MP0003137_abnormal_impulse_conducting0.88661827
119MP0002736_abnormal_nociception_after0.88551328
120MP0002108_abnormal_muscle_morphology0.87219941
121MP0000767_abnormal_smooth_muscle0.87150406
122MP0001286_abnormal_eye_development0.86630675
123MP0010030_abnormal_orbit_morphology0.86221106
124MP0003935_abnormal_craniofacial_develop0.86104302
125MP0002272_abnormal_nervous_system0.86099934
126MP0005508_abnormal_skeleton_morphology0.84275552
127MP0004215_abnormal_myocardial_fiber0.84088631
128MP0005646_abnormal_pituitary_gland0.83957358
129MP0002249_abnormal_larynx_morphology0.83463804
130MP0001963_abnormal_hearing_physiology0.83191635
131MP0002932_abnormal_joint_morphology0.83073001
132MP0005310_abnormal_salivary_gland0.82758554
133MP0001958_emphysema0.82740891
134MP0003283_abnormal_digestive_organ0.82318673
135MP0003315_abnormal_perineum_morphology0.81958363

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.05457884
2Asymmetry of the thorax (HP:0001555)3.85255820
3Intestinal atresia (HP:0011100)3.78361018
4True hermaphroditism (HP:0010459)3.66460231
5Hyperventilation (HP:0002883)3.65498720
6Pancreatic fibrosis (HP:0100732)3.16200916
7Pancreatic cysts (HP:0001737)3.08659542
8Abnormality of the labia minora (HP:0012880)3.03200033
9Abnormality of midbrain morphology (HP:0002418)3.02798398
10Molar tooth sign on MRI (HP:0002419)3.02798398
11Midline defect of the nose (HP:0004122)2.99588015
12Morphological abnormality of the middle ear (HP:0008609)2.95273112
13Heterochromia iridis (HP:0001100)2.93439078
14Abnormality of the parathyroid morphology (HP:0011766)2.90871464
15Abnormality of incisor morphology (HP:0011063)2.80199840
16Nephronophthisis (HP:0000090)2.76716206
17Thick nail (HP:0001805)2.74874689
18Increased IgM level (HP:0003496)2.67794684
19Optic nerve hypoplasia (HP:0000609)2.58471481
20Atonic seizures (HP:0010819)2.58378687
21Focal motor seizures (HP:0011153)2.52326948
22Fetal akinesia sequence (HP:0001989)2.48396886
23Abnormal lung lobation (HP:0002101)2.48147934
24Abnormality of the renal medulla (HP:0100957)2.43291910
25Gastrointestinal atresia (HP:0002589)2.41879609
26Aplasia/Hypoplasia of the sternum (HP:0006714)2.40150152
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.38745558
28Pachygyria (HP:0001302)2.37470984
29Akinesia (HP:0002304)2.37072051
30Broad ribs (HP:0000885)2.36982829
31Narrow forehead (HP:0000341)2.35571320
32Hepatoblastoma (HP:0002884)2.33310923
33Oligodactyly (HP:0012165)2.32418850
34Postaxial hand polydactyly (HP:0001162)2.29735079
35Chronic hepatic failure (HP:0100626)2.27869737
36Anencephaly (HP:0002323)2.27200589
37Hemiparesis (HP:0001269)2.27131994
38Preaxial hand polydactyly (HP:0001177)2.23765670
39Abnormality of dentin (HP:0010299)2.22919321
40Short 4th metacarpal (HP:0010044)2.22868048
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22868048
42Myelomeningocele (HP:0002475)2.21953628
43Exotropia (HP:0000577)2.19765475
44Colon cancer (HP:0003003)2.19701220
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.18882286
46Absent hand (HP:0004050)2.18832166
47Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18168823
48Medial flaring of the eyebrow (HP:0010747)2.17864970
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.17439891
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17439891
51Coronal craniosynostosis (HP:0004440)2.17068762
52Chin dimple (HP:0010751)2.15828376
53Glioma (HP:0009733)2.14482525
54Cystic liver disease (HP:0006706)2.14317567
55Limb dystonia (HP:0002451)2.14204662
56Microglossia (HP:0000171)2.13912412
57Septo-optic dysplasia (HP:0100842)2.12967924
58Postaxial foot polydactyly (HP:0001830)2.12324128
59Aqueductal stenosis (HP:0002410)2.12212868
60Vascular tortuosity (HP:0004948)2.11353096
61Syringomyelia (HP:0003396)2.10568572
62Spinal cord lesions (HP:0100561)2.10568572
63Anophthalmia (HP:0000528)2.07017674
64Arterial tortuosity (HP:0005116)2.05931212
65Focal seizures (HP:0007359)2.04338379
66Abnormality of the nasal septum (HP:0000419)2.03845801
67Pendular nystagmus (HP:0012043)2.02335055
68Occipital encephalocele (HP:0002085)2.02306743
69Intellectual disability, moderate (HP:0002342)2.01959060
70White forelock (HP:0002211)2.01594829
71Cupped ear (HP:0000378)2.01260234
72Abnormality of the corticospinal tract (HP:0002492)2.01162127
73Facial hemangioma (HP:0000329)2.00679456
74Bifid tongue (HP:0010297)2.00065164
75Labial hypoplasia (HP:0000066)1.99531746
76Neoplasm of the oral cavity (HP:0100649)1.99352705
77Palpebral edema (HP:0100540)1.99261276
78Adrenal hypoplasia (HP:0000835)1.97848693
79Sclerocornea (HP:0000647)1.97612256
80Long clavicles (HP:0000890)1.95757379
81Dandy-Walker malformation (HP:0001305)1.95693384
82Increased corneal curvature (HP:0100692)1.94742084
83Keratoconus (HP:0000563)1.94742084
84Hypoplastic labia majora (HP:0000059)1.94416368
85Congenital hepatic fibrosis (HP:0002612)1.90937796
86Cutaneous finger syndactyly (HP:0010554)1.90766182
87Congenital primary aphakia (HP:0007707)1.90337422
88Lissencephaly (HP:0001339)1.89583169
89Supernumerary ribs (HP:0005815)1.89578913
90Epidermoid cyst (HP:0200040)1.89329837
91Abnormality of the renal cortex (HP:0011035)1.89111477
92Adactyly (HP:0009776)1.88180786
93Sensory axonal neuropathy (HP:0003390)1.87862710
94Febrile seizures (HP:0002373)1.87858907
95Supernumerary spleens (HP:0009799)1.87387763
96Short tibia (HP:0005736)1.87372405
97Alacrima (HP:0000522)1.86437100
98Preaxial foot polydactyly (HP:0001841)1.85896345
99Hypoplastic female external genitalia (HP:0012815)1.85238676
100Abnormality of the astrocytes (HP:0100707)1.85015883
101Astrocytoma (HP:0009592)1.85015883
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84891526
103Shawl scrotum (HP:0000049)1.84827155
104Absent septum pellucidum (HP:0001331)1.84573104
105Abnormality of the ischium (HP:0003174)1.83672204
106Megalencephaly (HP:0001355)1.83082546
107Abnormality of the antihelix (HP:0009738)1.82770729
108Cortical dysplasia (HP:0002539)1.81024826
109Abnormality of chromosome stability (HP:0003220)1.80919172
110Scrotal hypoplasia (HP:0000046)1.80770076
111Gastroesophageal reflux (HP:0002020)1.79425027
112Hemivertebrae (HP:0002937)1.79382921
113Median cleft lip (HP:0000161)1.78058812
114Nephrogenic diabetes insipidus (HP:0009806)1.77917390
115Growth hormone deficiency (HP:0000824)1.76382924
116Abnormality of the 4th metacarpal (HP:0010012)1.75692218
117Meningocele (HP:0002435)1.75645964
118Abnormal hair whorl (HP:0010721)1.75162251
119Parakeratosis (HP:0001036)1.74708654
120Renal hypoplasia (HP:0000089)1.74280472
121Neoplasm of the adrenal cortex (HP:0100641)1.74137819
122Severe Myopia (HP:0011003)1.74134613
123Micropenis (HP:0000054)1.73751766
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.73276909
125Long nose (HP:0003189)1.73001594
126Soft skin (HP:0000977)1.72883184
127Conical tooth (HP:0000698)1.72412859
128Decreased lacrimation (HP:0000633)1.72130652
129Chorioretinal coloboma (HP:0000567)1.72087126
130Abnormality of the parietal bone (HP:0002696)1.71933546
131Overgrowth (HP:0001548)1.71882556
132Drooling (HP:0002307)1.71671272
133Excessive salivation (HP:0003781)1.71671272
134Abnormality of the labia majora (HP:0012881)1.71343665
135Patchy hypopigmentation of hair (HP:0011365)1.69972676
136Small epiphyses (HP:0010585)1.69704689
137Vitreoretinal degeneration (HP:0000655)1.68779385
138Abnormality of the septum pellucidum (HP:0007375)1.67714044
139Hypoplastic nipples (HP:0002557)1.66486897
140Increased number of teeth (HP:0011069)1.66215963
141Telecanthus (HP:0000506)1.65829421
142Flared iliac wings (HP:0002869)1.65824330
143Blue irides (HP:0000635)1.65311655
144Tented upper lip vermilion (HP:0010804)1.64223725
145Hypoplastic pelvis (HP:0008839)1.64190639
146Pulmonary artery stenosis (HP:0004415)1.64082179
147Narrow nasal bridge (HP:0000446)1.63333648
148Absent speech (HP:0001344)1.62422838
149Protruding tongue (HP:0010808)1.62243521
150Papillary thyroid carcinoma (HP:0002895)1.60869127
151Abnormality of the incisor (HP:0000676)1.59736614
152Abnormality of the nasolacrimal system (HP:0000614)1.57909097
153Mild short stature (HP:0003502)1.57317875
154Lymphangioma (HP:0100764)1.56912941
155Gait imbalance (HP:0002141)1.56475162
156Pulmonic stenosis (HP:0001642)1.56391577
157Inappropriate behavior (HP:0000719)1.56377645
158Vaginal atresia (HP:0000148)1.56135024
159Genital tract atresia (HP:0001827)1.56015646
160Cutaneous syndactyly (HP:0012725)1.54262781
161Supernumerary bones of the axial skeleton (HP:0009144)1.53056011
162Oligodactyly (hands) (HP:0001180)1.52560631
163Aplasia cutis congenita (HP:0001057)1.52467750
164Sporadic (HP:0003745)1.52329136
165Short foot (HP:0001773)1.51660823
166Abnormality of the phalanges of the hallux (HP:0010057)1.51248459
167Downturned corners of mouth (HP:0002714)1.50372541
168Hypothermia (HP:0002045)1.50164884
169Congenital malformation of the right heart (HP:0011723)1.49702367
170Double outlet right ventricle (HP:0001719)1.49702367
171Abnormality of the pulmonary veins (HP:0011718)1.49016178
172Hip dysplasia (HP:0001385)1.49002293
173Buphthalmos (HP:0000557)1.48304572
174Anomalous pulmonary venous return (HP:0010772)1.48030305
175Shallow orbits (HP:0000586)1.47823506
176Flat face (HP:0012368)1.47322295
177Polyphagia (HP:0002591)1.47131847
178Broad-based gait (HP:0002136)1.46924386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.89343664
2TNIK4.27290749
3MARK14.20859389
4WEE13.29815345
5ERBB33.20813847
6TRIM282.81197098
7BCR2.75143254
8PNCK2.63809433
9IRAK22.36459312
10TYRO32.29811548
11IRAK42.23541611
12DYRK22.12447168
13BUB12.08752940
14EPHB22.03477543
15MAP3K142.00875505
16CCNB11.97611959
17STK391.93712322
18IRAK11.88060931
19PLK21.86946971
20BRSK21.81382447
21YES11.81261660
22UHMK11.74891084
23BMPR21.73111925
24FES1.62001990
25PRKD31.60418274
26EPHA31.59993910
27PLK41.58902277
28MAP4K21.55080023
29EPHB11.53136319
30NTRK21.49547696
31NEK11.39796015
32NUAK11.38317404
33MAP2K71.37087969
34* MAPK131.32858529
35PRPF4B1.29158526
36BMPR1B1.22623132
37ACVR1B1.21743347
38CHUK1.18174020
39PAK31.16615635
40MKNK11.06280726
41NEK61.02110472
42KSR11.01743907
43STK31.01623251
44PDGFRB1.00975306
45IKBKB1.00466364
46PDGFRA0.94886290
47SIK20.91410184
48EIF2AK20.91079926
49PINK10.89854088
50AKT30.89770391
51ROCK20.88953698
52SGK2230.88777250
53SGK4940.88777250
54MAP3K40.87725008
55FGR0.87338121
56MKNK20.86484731
57FGFR20.84877352
58SIK30.84401062
59SGK20.84338793
60LIMK10.84299575
61NTRK30.83923648
62PRKCE0.83849503
63MINK10.82703939
64ICK0.77853822
65OXSR10.77763575
66NEK20.75397877
67CSNK1A1L0.74988300
68ZAK0.73376903
69GRK10.72916726
70PLK10.72910714
71GRK70.72327483
72EPHA40.72185424
73CSNK1G30.71842347
74TBK10.69455413
75DMPK0.66298660
76PBK0.66139682
77DYRK30.66033314
78SRPK10.64887532
79IKBKE0.63502640
80TTK0.62914629
81DDR20.62728306
82TGFBR10.61932492
83PHKG10.61880556
84PHKG20.61880556
85ADRBK20.61462123
86STK38L0.61211555
87* ROCK10.60271178
88BRSK10.59965281
89RAF10.59959435
90TAF10.58192040
91GSK3A0.58144685
92INSR0.58117719
93VRK10.57859874
94EIF2AK30.57546374
95CSNK1G20.57207840
96* PKN10.55530535
97ERBB20.54985262
98ADRBK10.54051862
99FRK0.52977850
100CLK10.52161466
101PRKCZ0.52122913
102CDK50.51558020
103CSNK1G10.49819786
104FER0.49482227
105LATS10.49318975
106MST40.48323050
107CSK0.48289535
108PRKCQ0.48030682
109INSRR0.46424718
110NEK90.45307722
111CDK80.45170390
112PLK30.44465376
113RPS6KA20.44447429
114PRKCG0.40408680
115FGFR10.40064834
116DYRK1A0.39989539
117CAMK2B0.39356593
118ATM0.39282157
119STK240.39006875
120FYN0.38901425
121NLK0.38370202
122CHEK20.37941108
123SGK10.37374319
124TIE10.37357157
125CDK140.36780857
126PIK3CA0.35419029
127PTK2B0.35380078
128CAMK2A0.34278262
129DYRK1B0.33895940
130CDK30.33532339
131WNK30.33307828
132CSNK1D0.33265125
133PRKG10.33132107
134PAK60.32996505
135PTK60.32919815
136SRC0.32708825
137NTRK10.32589671
138ABL20.31961560
139PRKDC0.31373648
140CDK180.30554814
141WNK40.28016882
142CAMK2D0.27241136
143ATR0.27131621
144CSNK1A10.26317906
145MARK30.26208999

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.97398655
2Axon guidance_Homo sapiens_hsa043602.66218180
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.57525300
4Propanoate metabolism_Homo sapiens_hsa006402.35522659
5Fanconi anemia pathway_Homo sapiens_hsa034602.26066850
6Non-homologous end-joining_Homo sapiens_hsa034502.15281451
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99466559
8Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.94515731
9Basal transcription factors_Homo sapiens_hsa030221.94140037
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92388993
11Phototransduction_Homo sapiens_hsa047441.90451616
12Butanoate metabolism_Homo sapiens_hsa006501.84281898
13Allograft rejection_Homo sapiens_hsa053301.80405327
14Viral myocarditis_Homo sapiens_hsa054161.74756739
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73480991
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71978586
17Homologous recombination_Homo sapiens_hsa034401.67200533
18Steroid biosynthesis_Homo sapiens_hsa001001.65510112
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62471853
20Graft-versus-host disease_Homo sapiens_hsa053321.60101677
21Oocyte meiosis_Homo sapiens_hsa041141.59601379
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45396680
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42558183
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37599667
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37473486
26Autoimmune thyroid disease_Homo sapiens_hsa053201.36000517
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35013914
28Cell cycle_Homo sapiens_hsa041101.33733537
29Cholinergic synapse_Homo sapiens_hsa047251.31710357
30Glutamatergic synapse_Homo sapiens_hsa047241.30577009
31Serotonergic synapse_Homo sapiens_hsa047261.30161554
32Dorso-ventral axis formation_Homo sapiens_hsa043201.27331040
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26254150
34Rheumatoid arthritis_Homo sapiens_hsa053231.25225849
35Amphetamine addiction_Homo sapiens_hsa050311.23330843
36Nicotine addiction_Homo sapiens_hsa050331.19519365
37Long-term depression_Homo sapiens_hsa047301.19467953
38Basal cell carcinoma_Homo sapiens_hsa052171.17277544
39Cocaine addiction_Homo sapiens_hsa050301.17209969
40Hedgehog signaling pathway_Homo sapiens_hsa043401.16886985
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16317238
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15647730
43Renal cell carcinoma_Homo sapiens_hsa052111.15362694
44Nitrogen metabolism_Homo sapiens_hsa009101.14916009
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13142503
46Prostate cancer_Homo sapiens_hsa052151.12247830
47Glioma_Homo sapiens_hsa052141.11601223
48Endometrial cancer_Homo sapiens_hsa052131.11378424
49Ether lipid metabolism_Homo sapiens_hsa005651.09535533
50Colorectal cancer_Homo sapiens_hsa052101.08883398
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07450658
52Phagosome_Homo sapiens_hsa041451.07176466
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06290232
54Melanoma_Homo sapiens_hsa052181.03431447
55Type I diabetes mellitus_Homo sapiens_hsa049401.02965762
56Chemokine signaling pathway_Homo sapiens_hsa040621.02281475
57Hippo signaling pathway_Homo sapiens_hsa043901.02270472
58Adherens junction_Homo sapiens_hsa045201.01489647
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01242319
60Focal adhesion_Homo sapiens_hsa045101.00716130
61ErbB signaling pathway_Homo sapiens_hsa040120.99529488
62Prion diseases_Homo sapiens_hsa050200.93370943
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91163873
64* MicroRNAs in cancer_Homo sapiens_hsa052060.90744318
65RNA degradation_Homo sapiens_hsa030180.90740886
66Taste transduction_Homo sapiens_hsa047420.90514652
67GABAergic synapse_Homo sapiens_hsa047270.89834599
68Morphine addiction_Homo sapiens_hsa050320.89590971
69Dopaminergic synapse_Homo sapiens_hsa047280.89495014
70Gap junction_Homo sapiens_hsa045400.89478843
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87975978
72Pancreatic cancer_Homo sapiens_hsa052120.86783688
73TGF-beta signaling pathway_Homo sapiens_hsa043500.86527028
74Chronic myeloid leukemia_Homo sapiens_hsa052200.86372015
75ECM-receptor interaction_Homo sapiens_hsa045120.85241585
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85120545
77Renin secretion_Homo sapiens_hsa049240.84372053
78Ras signaling pathway_Homo sapiens_hsa040140.84127377
79Shigellosis_Homo sapiens_hsa051310.83938423
80cAMP signaling pathway_Homo sapiens_hsa040240.83019705
81Osteoclast differentiation_Homo sapiens_hsa043800.82576961
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82428332
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81913568
84Salmonella infection_Homo sapiens_hsa051320.81154088
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81001089
86Circadian entrainment_Homo sapiens_hsa047130.80675455
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80651282
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80242234
89Proteoglycans in cancer_Homo sapiens_hsa052050.80136477
90TNF signaling pathway_Homo sapiens_hsa046680.80042585
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79969374
92Melanogenesis_Homo sapiens_hsa049160.79483920
93p53 signaling pathway_Homo sapiens_hsa041150.79332392
94Malaria_Homo sapiens_hsa051440.78938108
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78578532
96Wnt signaling pathway_Homo sapiens_hsa043100.78364799
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78263186
98African trypanosomiasis_Homo sapiens_hsa051430.78092459
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.77731732
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77155771
101Linoleic acid metabolism_Homo sapiens_hsa005910.77009277
102Measles_Homo sapiens_hsa051620.76432919
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76272689
104Toxoplasmosis_Homo sapiens_hsa051450.76239070
105Collecting duct acid secretion_Homo sapiens_hsa049660.75938010
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75820294
107Pertussis_Homo sapiens_hsa051330.75223729
108Oxytocin signaling pathway_Homo sapiens_hsa049210.73944423
109Vibrio cholerae infection_Homo sapiens_hsa051100.72565539
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.72541122
111Insulin secretion_Homo sapiens_hsa049110.70802531
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.70239321
113MAPK signaling pathway_Homo sapiens_hsa040100.69999008
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.69454436
115Olfactory transduction_Homo sapiens_hsa047400.69142337
116T cell receptor signaling pathway_Homo sapiens_hsa046600.68778478
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.68644895
118Type II diabetes mellitus_Homo sapiens_hsa049300.68171472
119Tight junction_Homo sapiens_hsa045300.66661792
120Long-term potentiation_Homo sapiens_hsa047200.66083076
121beta-Alanine metabolism_Homo sapiens_hsa004100.66082029
122Tryptophan metabolism_Homo sapiens_hsa003800.65797587
123Notch signaling pathway_Homo sapiens_hsa043300.65604133
124B cell receptor signaling pathway_Homo sapiens_hsa046620.64754051
125Choline metabolism in cancer_Homo sapiens_hsa052310.64638308
126mRNA surveillance pathway_Homo sapiens_hsa030150.64113283
127Amoebiasis_Homo sapiens_hsa051460.63954235
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63660623
129Fatty acid metabolism_Homo sapiens_hsa012120.63474056
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63176593
131Pathways in cancer_Homo sapiens_hsa052000.63145672
132Estrogen signaling pathway_Homo sapiens_hsa049150.63132726
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62499091
134GnRH signaling pathway_Homo sapiens_hsa049120.61892635
135Synaptic vesicle cycle_Homo sapiens_hsa047210.61592719
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61455332
137Platelet activation_Homo sapiens_hsa046110.61178737
138Asthma_Homo sapiens_hsa053100.60253558
139* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60023045
140Leishmaniasis_Homo sapiens_hsa051400.58830196
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58543859
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.58058177
143Selenocompound metabolism_Homo sapiens_hsa004500.57347208
144Salivary secretion_Homo sapiens_hsa049700.55517201
145Fat digestion and absorption_Homo sapiens_hsa049750.55293079
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.54974381
147Caffeine metabolism_Homo sapiens_hsa002320.53470888
148ABC transporters_Homo sapiens_hsa020100.53190775
149Regulation of autophagy_Homo sapiens_hsa041400.52499091
150Gastric acid secretion_Homo sapiens_hsa049710.51916085
151Circadian rhythm_Homo sapiens_hsa047100.48764317
152Lysine degradation_Homo sapiens_hsa003100.47066693
153Calcium signaling pathway_Homo sapiens_hsa040200.46772754
154Alcoholism_Homo sapiens_hsa050340.43026995
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.41999504
156cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41401806
157Glycerolipid metabolism_Homo sapiens_hsa005610.41035943
158Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40543657
159Rap1 signaling pathway_Homo sapiens_hsa040150.38771500
160Retinol metabolism_Homo sapiens_hsa008300.37646407
161Peroxisome_Homo sapiens_hsa041460.36666821
162Fatty acid degradation_Homo sapiens_hsa000710.35902670
163Fatty acid elongation_Homo sapiens_hsa000620.31711598

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