MARCKSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.58290555
2postsynaptic membrane organization (GO:0001941)4.92262728
3nucleobase catabolic process (GO:0046113)4.78301007
4presynaptic membrane assembly (GO:0097105)4.52273353
5cell migration in hindbrain (GO:0021535)4.39553995
6presynaptic membrane organization (GO:0097090)4.31465926
7neuron cell-cell adhesion (GO:0007158)4.25562460
8layer formation in cerebral cortex (GO:0021819)4.18286165
9regulation of NFAT protein import into nucleus (GO:0051532)3.91293087
10central nervous system projection neuron axonogenesis (GO:0021952)3.88253720
11protein localization to synapse (GO:0035418)3.84278622
12peptidyl-arginine omega-N-methylation (GO:0035247)3.68400024
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68305339
14negative regulation of microtubule polymerization (GO:0031115)3.64522480
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.64252531
16pre-miRNA processing (GO:0031054)3.58699652
17paraxial mesoderm development (GO:0048339)3.56916416
18axonal fasciculation (GO:0007413)3.52729409
19DNA unwinding involved in DNA replication (GO:0006268)3.48297247
20neuronal stem cell maintenance (GO:0097150)3.46805948
21peptidyl-arginine methylation (GO:0018216)3.46244836
22peptidyl-arginine N-methylation (GO:0035246)3.46244836
23planar cell polarity pathway involved in neural tube closure (GO:0090179)3.44057691
24negative regulation of axon guidance (GO:1902668)3.41093236
25lateral sprouting from an epithelium (GO:0060601)3.40804261
26protein-DNA complex disassembly (GO:0032986)3.39680738
27nucleosome disassembly (GO:0006337)3.39680738
28semaphorin-plexin signaling pathway (GO:0071526)3.37234037
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.37072091
30negative regulation of oligodendrocyte differentiation (GO:0048715)3.36044198
31vocalization behavior (GO:0071625)3.32148909
32negative regulation of axon extension involved in axon guidance (GO:0048843)3.27028768
33dendritic spine morphogenesis (GO:0060997)3.26134271
34convergent extension (GO:0060026)3.22051233
35negative regulation of RNA splicing (GO:0033119)3.20047695
36establishment of nucleus localization (GO:0040023)3.14205447
37negative regulation of catenin import into nucleus (GO:0035414)3.13366568
38polarized epithelial cell differentiation (GO:0030859)3.11979369
39regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09115597
40histone arginine methylation (GO:0034969)3.08757142
41embryonic foregut morphogenesis (GO:0048617)3.08542992
42establishment of tissue polarity (GO:0007164)3.07427405
43establishment of planar polarity (GO:0001736)3.07427405
44central nervous system myelination (GO:0022010)3.06905219
45axon ensheathment in central nervous system (GO:0032291)3.06905219
46positive regulation of synapse assembly (GO:0051965)3.06135155
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.04990432
48negative regulation of mRNA processing (GO:0050686)3.04738358
49neuron recognition (GO:0008038)2.98453615
50exploration behavior (GO:0035640)2.95436176
51ionotropic glutamate receptor signaling pathway (GO:0035235)2.95155361
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89427029
53apical protein localization (GO:0045176)2.88974723
54locomotory exploration behavior (GO:0035641)2.88328872
55auditory behavior (GO:0031223)2.85888432
56hippo signaling (GO:0035329)2.85063831
57neurotransmitter-gated ion channel clustering (GO:0072578)2.84463187
58synapse assembly (GO:0007416)2.82305770
59heterochromatin organization (GO:0070828)2.82169453
60adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.80366201
61regulation of oligodendrocyte differentiation (GO:0048713)2.79759159
62central nervous system neuron axonogenesis (GO:0021955)2.78775198
63axon extension (GO:0048675)2.76839506
64regulation of synaptic vesicle exocytosis (GO:2000300)2.74146140
65positive regulation of oligodendrocyte differentiation (GO:0048714)2.74075785
66cranial nerve morphogenesis (GO:0021602)2.73696157
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73013044
68regulation of short-term neuronal synaptic plasticity (GO:0048172)2.71686667
69axon extension involved in axon guidance (GO:0048846)2.71571353
70neuron projection extension involved in neuron projection guidance (GO:1902284)2.71571353
71dendrite morphogenesis (GO:0048813)2.69436827
72ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.69386662
73G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.69200850
74positive regulation of filopodium assembly (GO:0051491)2.68708129
75regulation of synapse structural plasticity (GO:0051823)2.67882120
76negative regulation of axon extension (GO:0030517)2.67351415
77lung-associated mesenchyme development (GO:0060484)2.67052444
78establishment or maintenance of monopolar cell polarity (GO:0061339)2.66327405
79establishment of monopolar cell polarity (GO:0061162)2.66327405
80cerebellar Purkinje cell layer development (GO:0021680)2.65756411
81retinal ganglion cell axon guidance (GO:0031290)2.65373505
82skeletal muscle organ development (GO:0060538)2.65043834
83mesenchymal to epithelial transition (GO:0060231)2.64669817
84lens fiber cell development (GO:0070307)2.64547916
85proximal/distal pattern formation (GO:0009954)2.61273386
86positive regulation of RNA splicing (GO:0033120)2.60611686
87camera-type eye morphogenesis (GO:0048593)2.60432535
88regulation of chromatin binding (GO:0035561)2.60330515
89cell-cell junction maintenance (GO:0045217)2.59202441
90positive regulation of dendritic spine morphogenesis (GO:0061003)2.59191305
91response to auditory stimulus (GO:0010996)2.59053208
92dosage compensation (GO:0007549)2.59017666
93gastrulation with mouth forming second (GO:0001702)2.58792272
94dopaminergic neuron differentiation (GO:0071542)2.57595611
95ephrin receptor signaling pathway (GO:0048013)2.56520707
96mechanosensory behavior (GO:0007638)2.56234857
97regulation of glutamate receptor signaling pathway (GO:1900449)2.54665565
98establishment of mitochondrion localization (GO:0051654)2.53879642
99neuron migration (GO:0001764)2.52844898
100mitochondrion transport along microtubule (GO:0047497)2.52261211
101establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52261211
102glial cell proliferation (GO:0014009)2.51913242
103response to pheromone (GO:0019236)2.51101841
104synaptic vesicle maturation (GO:0016188)2.51098682
105urogenital system development (GO:0001655)2.50716114
106neuromuscular process controlling balance (GO:0050885)2.48692236
107neuron projection extension (GO:1990138)2.48567312
108forebrain neuron differentiation (GO:0021879)2.48432682
109neuronal ion channel clustering (GO:0045161)2.48217050
110cerebellar granule cell differentiation (GO:0021707)2.47998583
111epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.47444045
112mRNA splice site selection (GO:0006376)2.46760172
113transmission of nerve impulse (GO:0019226)2.44871733
114regulation of respiratory system process (GO:0044065)2.44814241
115outer ear morphogenesis (GO:0042473)2.44691517
116establishment of apical/basal cell polarity (GO:0035089)2.43668342
117neuron fate determination (GO:0048664)2.42754381
118regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.42735246
119forebrain development (GO:0030900)2.42457185
120establishment or maintenance of apical/basal cell polarity (GO:0035088)2.41758972
121establishment or maintenance of bipolar cell polarity (GO:0061245)2.41758972
122negative regulation of mRNA metabolic process (GO:1903312)2.40876350
123cerebral cortex radially oriented cell migration (GO:0021799)2.40149092
124G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.39800690
125cochlea morphogenesis (GO:0090103)2.39606550
126positive regulation of synapse maturation (GO:0090129)2.39533160
127positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.39004657
128regulation of axon guidance (GO:1902667)2.38545449
129RNA localization (GO:0006403)2.38413814
130DNA damage response, detection of DNA damage (GO:0042769)2.38225334
131spliceosomal tri-snRNP complex assembly (GO:0000244)2.37960289
132cranial nerve development (GO:0021545)2.37636349
133epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36856493
134negative regulation of axonogenesis (GO:0050771)2.36688735
135calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.36450058
136midbrain development (GO:0030901)2.35829670
137positive regulation of dendrite morphogenesis (GO:0050775)2.35712136
138synaptic transmission, glutamatergic (GO:0035249)2.35671684
139alternative mRNA splicing, via spliceosome (GO:0000380)2.35499456
140generation of neurons (GO:0048699)2.33844161
141clathrin coat assembly (GO:0048268)2.32444392
142regulation of telomere maintenance via telomerase (GO:0032210)2.31879044
143negative regulation of JAK-STAT cascade (GO:0046426)2.31840633
144spinal cord development (GO:0021510)2.30698010
145intracellular estrogen receptor signaling pathway (GO:0030520)2.29581563
146cell surface receptor signaling pathway involved in heart development (GO:0061311)2.29569275
147regulation of RNA export from nucleus (GO:0046831)2.28743263
148astrocyte differentiation (GO:0048708)2.27832538
149hippocampus development (GO:0021766)2.26791355
150regulation of establishment of planar polarity (GO:0090175)2.26014395
151Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.25094172
152limb bud formation (GO:0060174)2.24465774
153regulation of gene silencing by miRNA (GO:0060964)2.24245918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.64764833
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.38994030
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.09729054
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.05904514
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.94079846
6* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.93406742
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.60724938
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57545829
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44928194
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.37497788
11EZH2_22144423_ChIP-Seq_EOC_Human2.34572617
12SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.26786560
13ZFP281_27345836_Chip-Seq_ESCs_Mouse2.26060347
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16981967
15SOX2_18555785_ChIP-Seq_MESCs_Mouse2.16085815
16* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.09148869
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08954721
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.05594033
19KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.01681518
20MYC_22102868_ChIP-Seq_BL_Human1.98269924
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96465239
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.95094972
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94465388
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.93906891
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87266154
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.86450524
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84149701
28REST_21632747_ChIP-Seq_MESCs_Mouse1.84127027
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83262860
30RING1B_27294783_Chip-Seq_NPCs_Mouse1.82968256
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.81391756
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81339450
33OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.80294340
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75387486
35* KDM2B_26808549_Chip-Seq_DND41_Human1.68140563
36RNF2_27304074_Chip-Seq_NSC_Mouse1.66692389
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66234930
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63035443
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62122335
40* KDM2B_26808549_Chip-Seq_K562_Human1.61249239
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.60443507
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58156279
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57452624
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.57018378
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.55480459
46* XRN2_22483619_ChIP-Seq_HELA_Human1.54670410
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.53282797
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53125414
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51496425
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.48870280
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48639448
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47657121
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.46824884
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.46079657
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45753306
56* TP53_20018659_ChIP-ChIP_R1E_Mouse1.44423159
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43220186
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.43018827
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42563368
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42386024
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42076598
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42076598
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42076598
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37989307
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36720488
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.34938874
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34730953
68* KDM2B_26808549_Chip-Seq_JURKAT_Human1.34581293
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34093455
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33904839
71NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33137568
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.32093076
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30890948
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30320065
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29706422
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.29628499
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28333590
78PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28165166
79* CTCF_27219007_Chip-Seq_Bcells_Human1.27852742
80* ELK3_25401928_ChIP-Seq_HUVEC_Human1.27832380
81EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27517514
82RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27517514
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27154055
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.25732325
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25276385
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24814035
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24457228
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24058339
89TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23963108
90ZNF263_19887448_ChIP-Seq_K562_Human1.23938026
91VDR_21846776_ChIP-Seq_THP-1_Human1.22535907
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19454447
93* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19086628
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17897694
95CIITA_25753668_ChIP-Seq_RAJI_Human1.17558878
96TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17021391
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15963420
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.15725494
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.15029150
100* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14459874
101* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13155766
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12275288
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.11346470
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10540276
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10344071
106TP63_17297297_ChIP-ChIP_HaCaT_Human1.09234058
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08177384
108POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08136373
109DROSHA_22980978_ChIP-Seq_HELA_Human1.07911688
110* TCF7_22412390_ChIP-Seq_EML_Mouse1.07115729
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06834441
112POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06685896
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06602209
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06327548
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05878301
116SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05795607
117OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05345606
118MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04687959
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04112995
120SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03705336
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03393084
122ISL1_27105846_Chip-Seq_CPCs_Mouse1.03376842
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02985059
124ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00720344
125* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.99677449
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98998902
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96946296
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92960435
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92450462
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91476251
131* LXR_22292898_ChIP-Seq_THP-1_Human0.91363318
132* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91034461
133RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87100243
134EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86433853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.84416844
2MP0002653_abnormal_ependyma_morphology3.36687875
3MP0010030_abnormal_orbit_morphology3.22297527
4* MP0000778_abnormal_nervous_system3.02887223
5MP0002822_catalepsy2.78507895
6MP0003122_maternal_imprinting2.64342514
7MP0003119_abnormal_digestive_system2.31637918
8MP0009053_abnormal_anal_canal2.27719604
9MP0000569_abnormal_digit_pigmentation2.22884376
10MP0003121_genomic_imprinting2.22853158
11MP0005076_abnormal_cell_differentiation2.22279101
12MP0003635_abnormal_synaptic_transmissio2.02774122
13MP0003315_abnormal_perineum_morphology1.97425365
14* MP0003861_abnormal_nervous_system1.97057576
15MP0001348_abnormal_lacrimal_gland1.91010010
16MP0003123_paternal_imprinting1.88332521
17MP0002282_abnormal_trachea_morphology1.79486801
18MP0003385_abnormal_body_wall1.78337248
19MP0003890_abnormal_embryonic-extraembry1.78336546
20MP0008789_abnormal_olfactory_epithelium1.76982848
21MP0004133_heterotaxia1.75705904
22MP0002102_abnormal_ear_morphology1.75302750
23MP0005187_abnormal_penis_morphology1.70722475
24MP0003136_yellow_coat_color1.67647258
25MP0003942_abnormal_urinary_system1.62641119
26MP0003787_abnormal_imprinting1.62109355
27MP0004858_abnormal_nervous_system1.61591728
28MP0000049_abnormal_middle_ear1.59998617
29MP0001188_hyperpigmentation1.59982880
30MP0002734_abnormal_mechanical_nocicepti1.59905600
31MP0003938_abnormal_ear_development1.57735685
32MP0004859_abnormal_synaptic_plasticity1.57567028
33MP0001293_anophthalmia1.50968507
34MP0002084_abnormal_developmental_patter1.49005924
35MP0002735_abnormal_chemical_nociception1.48277818
36MP0003937_abnormal_limbs/digits/tail_de1.47995823
37* MP0002085_abnormal_embryonic_tissue1.46899549
38MP0002751_abnormal_autonomic_nervous1.45823801
39MP0002938_white_spotting1.44744221
40MP0005423_abnormal_somatic_nervous1.44393708
41MP0003115_abnormal_respiratory_system1.43790994
42MP0002932_abnormal_joint_morphology1.42450623
43MP0002184_abnormal_innervation1.42203912
44MP0002572_abnormal_emotion/affect_behav1.41257207
45MP0004197_abnormal_fetal_growth/weight/1.41163381
46MP0004885_abnormal_endolymph1.39314912
47MP0002064_seizures1.38552932
48MP0002557_abnormal_social/conspecific_i1.37749534
49MP0009278_abnormal_bone_marrow1.37198475
50MP0002697_abnormal_eye_size1.37144698
51MP0001849_ear_inflammation1.36991782
52MP0005499_abnormal_olfactory_system1.36422764
53MP0005394_taste/olfaction_phenotype1.36422764
54MP0000566_synostosis1.35855152
55MP0003283_abnormal_digestive_organ1.35535752
56MP0005623_abnormal_meninges_morphology1.33356736
57MP0002116_abnormal_craniofacial_bone1.33244485
58MP0000428_abnormal_craniofacial_morphol1.32591705
59MP0002092_abnormal_eye_morphology1.31259783
60MP0009379_abnormal_foot_pigmentation1.30339825
61MP0000955_abnormal_spinal_cord1.29854519
62* MP0002152_abnormal_brain_morphology1.29219204
63MP0005248_abnormal_Harderian_gland1.29108457
64MP0008932_abnormal_embryonic_tissue1.28846410
65MP0001730_embryonic_growth_arrest1.28481171
66MP0003077_abnormal_cell_cycle1.27405973
67MP0003755_abnormal_palate_morphology1.27340251
68MP0000534_abnormal_ureter_morphology1.26602323
69MP0009745_abnormal_behavioral_response1.25144901
70MP0000733_abnormal_muscle_development1.24319932
71MP0001486_abnormal_startle_reflex1.23068996
72MP0000350_abnormal_cell_proliferation1.22873229
73MP0009672_abnormal_birth_weight1.21567162
74MP0002249_abnormal_larynx_morphology1.20772896
75MP0002736_abnormal_nociception_after1.20426273
76MP0003111_abnormal_nucleus_morphology1.17989529
77MP0002081_perinatal_lethality1.17241376
78MP0002752_abnormal_somatic_nervous1.16571209
79MP0002233_abnormal_nose_morphology1.16149899
80MP0003303_peritoneal_inflammation1.15478812
81MP0002272_abnormal_nervous_system1.11388970
82MP0001286_abnormal_eye_development1.10779862
83MP0003935_abnormal_craniofacial_develop1.10009028
84MP0004811_abnormal_neuron_physiology1.09418163
85MP0001984_abnormal_olfaction1.08964794
86MP0002733_abnormal_thermal_nociception1.08962621
87MP0000631_abnormal_neuroendocrine_gland1.08034935
88MP0001697_abnormal_embryo_size1.07123774
89MP0002234_abnormal_pharynx_morphology1.05766853
90MP0003567_abnormal_fetal_cardiomyocyte1.05691277
91MP0001968_abnormal_touch/_nociception1.05670276
92MP0001502_abnormal_circadian_rhythm1.04932681
93MP0002111_abnormal_tail_morphology1.03994920
94MP0001346_abnormal_lacrimal_gland1.03987776
95MP0004270_analgesia1.03297811
96MP0001672_abnormal_embryogenesis/_devel1.03179812
97MP0005380_embryogenesis_phenotype1.03179812
98MP0008007_abnormal_cellular_replicative1.03081820
99MP0010352_gastrointestinal_tract_polyps1.00253530
100MP0001970_abnormal_pain_threshold0.99521835
101MP0004957_abnormal_blastocyst_morpholog0.99209884
102MP0002882_abnormal_neuron_morphology0.98189048
103MP0009250_abnormal_appendicular_skeleto0.96700076
104MP0008057_abnormal_DNA_replication0.94804035
105MP0002067_abnormal_sensory_capabilities0.94065097
106MP0003880_abnormal_central_pattern0.93365138
107MP0002088_abnormal_embryonic_growth/wei0.92208638
108MP0006276_abnormal_autonomic_nervous0.91129774
109MP0002066_abnormal_motor_capabilities/c0.91129271
110MP0003984_embryonic_growth_retardation0.90826019
111MP0003329_amyloid_beta_deposits0.90060567
112MP0001529_abnormal_vocalization0.88414367
113MP0005645_abnormal_hypothalamus_physiol0.87956103
114MP0003634_abnormal_glial_cell0.87899691
115MP0003705_abnormal_hypodermis_morpholog0.87751139
116MP0010094_abnormal_chromosome_stability0.86919835
117MP0001485_abnormal_pinna_reflex0.85744363
118MP0004742_abnormal_vestibular_system0.85331458
119MP0002080_prenatal_lethality0.85106775
120MP0000432_abnormal_head_morphology0.85063134
121MP0005386_behavior/neurological_phenoty0.84937979
122MP0004924_abnormal_behavior0.84937979
123MP0000462_abnormal_digestive_system0.84854837
124MP0002089_abnormal_postnatal_growth/wei0.84620986
125MP0005257_abnormal_intraocular_pressure0.84511001
126MP0000026_abnormal_inner_ear0.83403067
127MP0000579_abnormal_nail_morphology0.83091927
128MP0002063_abnormal_learning/memory/cond0.83044178
129MP0005367_renal/urinary_system_phenotyp0.82241023
130MP0000516_abnormal_urinary_system0.82241023
131MP0001299_abnormal_eye_distance/0.81599576
132MP0006292_abnormal_olfactory_placode0.81030763
133MP0001963_abnormal_hearing_physiology0.80977264
134MP0002114_abnormal_axial_skeleton0.79907686

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.85921096
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.85921096
3Myokymia (HP:0002411)3.85213694
4Renal duplication (HP:0000075)3.44298658
5Cortical dysplasia (HP:0002539)3.36115640
6Hyperacusis (HP:0010780)3.25798855
7Abnormality of the 4th metacarpal (HP:0010012)2.97713768
8Overriding aorta (HP:0002623)2.94518273
9Amyotrophic lateral sclerosis (HP:0007354)2.92695115
10Elfin facies (HP:0004428)2.56182154
11Ependymoma (HP:0002888)2.53415972
12Abnormality of the astrocytes (HP:0100707)2.49508156
13Astrocytoma (HP:0009592)2.49508156
14Turricephaly (HP:0000262)2.44780831
15High anterior hairline (HP:0009890)2.43561183
16Partial duplication of thumb phalanx (HP:0009944)2.42009865
17Trigonocephaly (HP:0000243)2.41733125
18Insomnia (HP:0100785)2.41086678
19Atrophy/Degeneration involving motor neurons (HP:0007373)2.40355621
20Shallow orbits (HP:0000586)2.40100006
21Focal motor seizures (HP:0011153)2.37128015
22Abnormality of the labia minora (HP:0012880)2.36167799
23Shoulder girdle muscle weakness (HP:0003547)2.34684430
24Increased nuchal translucency (HP:0010880)2.32170318
25Generalized hypotonia (HP:0001290)2.29351020
26Renovascular hypertension (HP:0100817)2.28731759
27Abnormality of the lower motor neuron (HP:0002366)2.27349825
28Cutaneous syndactyly (HP:0012725)2.26715339
29Apathy (HP:0000741)2.26083427
30Hepatoblastoma (HP:0002884)2.26053206
31Megalocornea (HP:0000485)2.25305911
32Cutaneous finger syndactyly (HP:0010554)2.24978848
33Lissencephaly (HP:0001339)2.23348216
34Abnormal number of incisors (HP:0011064)2.20559254
35Medulloblastoma (HP:0002885)2.19522633
36Morphological abnormality of the inner ear (HP:0011390)2.18278583
37Partial duplication of the phalanx of hand (HP:0009999)2.18199221
38Amblyopia (HP:0000646)2.16510645
39Diminished motivation (HP:0000745)2.14083904
40Esophageal atresia (HP:0002032)2.13670165
41Split foot (HP:0001839)2.12871764
42Vitreoretinal degeneration (HP:0000655)2.12592349
43Broad distal phalanx of finger (HP:0009836)2.07824043
44Abnormality of the diencephalon (HP:0010662)2.07491246
45Broad alveolar ridges (HP:0000187)2.07335538
46Bronchomalacia (HP:0002780)2.07092329
47Rib fusion (HP:0000902)2.06271877
48Aplasia involving bones of the extremities (HP:0009825)2.06263547
49Aplasia involving bones of the upper limbs (HP:0009823)2.06263547
50Aplasia of the phalanges of the hand (HP:0009802)2.06263547
51Pointed chin (HP:0000307)2.06106876
52Flat cornea (HP:0007720)2.06077479
53Pelvic girdle muscle weakness (HP:0003749)2.05345863
54Retinal dysplasia (HP:0007973)2.04480356
55Sacral dimple (HP:0000960)2.03387601
56Patellar dislocation (HP:0002999)2.00982676
57Colon cancer (HP:0003003)2.00251872
58Broad thumb (HP:0011304)1.99358814
59Sleep apnea (HP:0010535)1.99169796
60Pachygyria (HP:0001302)1.96779849
61Aplasia/Hypoplasia of the sternum (HP:0006714)1.94657625
62Bilateral microphthalmos (HP:0007633)1.94640423
63Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94297075
64Hypoplasia of the brainstem (HP:0002365)1.94297075
65Leiomyosarcoma (HP:0100243)1.92661802
66Uterine leiomyosarcoma (HP:0002891)1.92661802
67Glioma (HP:0009733)1.91724842
68Skull defect (HP:0001362)1.91709686
69Spina bifida occulta (HP:0003298)1.90443456
70Proximal placement of thumb (HP:0009623)1.89631426
71Polyphagia (HP:0002591)1.89485393
72Limb dystonia (HP:0002451)1.89411123
73Focal seizures (HP:0007359)1.88837137
74Large earlobe (HP:0009748)1.88279278
75Megalencephaly (HP:0001355)1.87701694
76Neoplasm of the heart (HP:0100544)1.87676273
77Peripheral hypomyelination (HP:0007182)1.87447534
78Abnormality of the aortic arch (HP:0012303)1.85749030
79Absent septum pellucidum (HP:0001331)1.83780214
80Patellar aplasia (HP:0006443)1.83738861
81Lymphangioma (HP:0100764)1.82592874
82Hemivertebrae (HP:0002937)1.82337905
83Hallux valgus (HP:0001822)1.82319886
84Abnormality of the hip-girdle musculature (HP:0001445)1.82100283
85Abnormality of the musculature of the pelvis (HP:0001469)1.82100283
86Deviation of the hallux (HP:0010051)1.81696812
87Heterotopia (HP:0002282)1.81396488
88Renal hypoplasia (HP:0000089)1.80624839
89Shawl scrotum (HP:0000049)1.80078666
90Anterior segment dysgenesis (HP:0007700)1.79949706
91Choanal stenosis (HP:0000452)1.79426402
92Abnormality of the intervertebral disk (HP:0005108)1.79170061
93Aplasia/Hypoplasia of the patella (HP:0006498)1.79168241
94Broad phalanges of the hand (HP:0009768)1.78497075
95Wrist flexion contracture (HP:0001239)1.78251579
96Drooling (HP:0002307)1.78115696
97Abnormality of the corticospinal tract (HP:0002492)1.77766212
98Concave nail (HP:0001598)1.75928583
99Supranuclear gaze palsy (HP:0000605)1.75906691
100Midline defect of the nose (HP:0004122)1.75690233
101Disinhibition (HP:0000734)1.75461878
102Deviation of the thumb (HP:0009603)1.75134756
103Broad finger (HP:0001500)1.74995818
104Epileptic encephalopathy (HP:0200134)1.72105970
105Hypoventilation (HP:0002791)1.70750582
106Germ cell neoplasia (HP:0100728)1.70536042
107Degeneration of anterior horn cells (HP:0002398)1.70273090
108Abnormality of the anterior horn cell (HP:0006802)1.70273090
109Ankle clonus (HP:0011448)1.69949969
110Maternal diabetes (HP:0009800)1.69819937
111Selective tooth agenesis (HP:0001592)1.68985806
112Humeroradial synostosis (HP:0003041)1.68240857
113Synostosis involving the elbow (HP:0003938)1.68240857
114Morphological abnormality of the middle ear (HP:0008609)1.67887122
115Pseudobulbar signs (HP:0002200)1.67198104
116Urinary urgency (HP:0000012)1.66990877
117Porencephaly (HP:0002132)1.66771023
118Oligodactyly (HP:0012165)1.65710027
119Facial hemangioma (HP:0000329)1.65692272
120Coronal craniosynostosis (HP:0004440)1.65497094
121Preaxial foot polydactyly (HP:0001841)1.65090166
122Aqueductal stenosis (HP:0002410)1.64220856
123Anophthalmia (HP:0000528)1.63902956
124Malignant gastrointestinal tract tumors (HP:0006749)1.63790843
125Gastrointestinal carcinoma (HP:0002672)1.63790843
126Septo-optic dysplasia (HP:0100842)1.63574801
127Short philtrum (HP:0000322)1.63417650
128Arnold-Chiari malformation (HP:0002308)1.63170536
129Missing ribs (HP:0000921)1.63145837
130Atresia of the external auditory canal (HP:0000413)1.62150560
131Duplication of thumb phalanx (HP:0009942)1.62017015
132Omphalocele (HP:0001539)1.61699369
133Heterochromia iridis (HP:0001100)1.61334955
134Anteriorly placed anus (HP:0001545)1.60949097
135Abnormality of the septum pellucidum (HP:0007375)1.60810516
136Spastic gait (HP:0002064)1.60536625
137Insidious onset (HP:0003587)1.60452692
138Termporal pattern (HP:0011008)1.60452692
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59668157
140Short phalanx of the thumb (HP:0009660)1.59418750
141Impaired vibration sensation in the lower limbs (HP:0002166)1.59316183
142Myelomeningocele (HP:0002475)1.58967172
143Optic nerve hypoplasia (HP:0000609)1.58864273
144Polymicrogyria (HP:0002126)1.58827202
145Abnormality of cochlea (HP:0000375)1.58802339
146Neoplasm of the oral cavity (HP:0100649)1.57898623
147Thin ribs (HP:0000883)1.57813615
148Excessive salivation (HP:0003781)1.57273931
149Obsessive-compulsive behavior (HP:0000722)1.56027327
150Transitional cell carcinoma of the bladder (HP:0006740)1.55814195
151Degeneration of the lateral corticospinal tracts (HP:0002314)1.55740716
152Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.55740716
153Renal cell carcinoma (HP:0005584)1.55220744
154Neonatal short-limb short stature (HP:0008921)1.54989655
155Vertebral fusion (HP:0002948)1.54317235
156Abnormality of the phalanges of the hallux (HP:0010057)1.53994896
157Long palpebral fissure (HP:0000637)1.53936861
158Exotropia (HP:0000577)1.53751955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.46141463
2CASK3.73599667
3EPHB23.53491230
4KSR13.19605057
5DYRK23.01406902
6MAP3K102.80294673
7BCR2.75548933
8TYRO32.39156010
9ICK2.38930021
10SIK32.30366104
11ERBB32.26003958
12TESK22.16387297
13LIMK12.15454900
14PASK2.12718892
15TNIK2.00993940
16NTRK11.92708349
17EPHA41.80001325
18NTRK21.79621722
19PRKD31.75685681
20MAP3K91.71896926
21UHMK11.69658507
22LATS21.69292426
23SIK21.66684146
24CDK121.60368869
25TESK11.59700179
26CDC71.57743037
27MAP2K71.56507035
28DYRK31.54409745
29FGFR21.52332747
30VRK21.48605373
31MINK11.48464148
32MKNK11.43633930
33TRIB31.43508588
34CSNK1G31.33043780
35CSNK1A1L1.31044283
36PAK61.25813419
37ERBB21.23975312
38PAK41.21814998
39NTRK31.19613801
40MAPK131.19211311
41TGFBR11.10327221
42CSNK1G21.06543429
43PDGFRA1.04368205
44BUB11.02525313
45TAF10.99812054
46SMG10.99627198
47NEK20.97860127
48PKN20.97714204
49PTK60.97552849
50CAMK1G0.95247103
51CDK140.93100296
52CDK180.93007428
53ALK0.92979107
54BRD40.92635055
55FGFR10.85067373
56PNCK0.84941081
57SIK10.82268269
58SCYL20.81885485
59CSNK1G10.81853694
60CDK150.81779315
61PRKCG0.80344180
62DDR20.80319949
63DYRK1B0.79806747
64SRPK10.75778107
65PAK30.75583734
66CDK11A0.75532840
67SGK2230.74986913
68SGK4940.74986913
69MARK20.74852381
70WNK30.71930590
71ILK0.71265640
72MTOR0.71228300
73MAP2K40.69318652
74PHKG20.69013619
75PHKG10.69013619
76EEF2K0.67753172
77CAMK1D0.67603939
78PKN10.66606270
79CDK70.66283695
80KSR20.64837621
81RIPK10.64271655
82AURKA0.63343708
83MAPK150.63013363
84IRAK20.62553268
85CHEK20.62152174
86CHUK0.61537368
87PRKCZ0.61059600
88RPS6KA10.57730881
89VRK10.57073899
90CHEK10.55322708
91AKT20.54814914
92DYRK1A0.54576334
93MAPK90.53814417
94PAK10.52773893
95FGR0.52427538
96NEK10.51758181
97ROCK20.50661617
98TSSK60.50404442
99MAP2K20.50388073
100WEE10.48366361
101CDK50.47775469
102RET0.47759756
103CSNK1D0.47694757
104MKNK20.47417361
105CDK20.47214086
106PTK20.47145626
107PAK20.44541642
108CDK10.44246046
109PLK10.43707725
110ARAF0.43667511
111CLK10.43283817
112PRKDC0.42586432
113MAP3K40.42460410
114EPHB10.42185842
115PLK30.41858607
116RPS6KA20.41661413
117MAP3K110.41232304
118CAMK2B0.41227940
119FGFR40.40840003
120GSK3B0.39645254
121CDK190.39601725
122PRKCI0.39231571
123CAMKK10.37806391
124BMX0.37434568
125CSNK1E0.36705960
126MAPK100.36370769
127DMPK0.36328988
128TIE10.36059440
129BRSK10.33929341

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.74142140
2Basal cell carcinoma_Homo sapiens_hsa052172.73315017
3Axon guidance_Homo sapiens_hsa043602.51874891
4Notch signaling pathway_Homo sapiens_hsa043302.34524113
5Spliceosome_Homo sapiens_hsa030402.31084095
6Hippo signaling pathway_Homo sapiens_hsa043902.23322034
7Hedgehog signaling pathway_Homo sapiens_hsa043402.15953165
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.01975034
9Cocaine addiction_Homo sapiens_hsa050302.01019237
10Colorectal cancer_Homo sapiens_hsa052101.98861035
11mRNA surveillance pathway_Homo sapiens_hsa030151.84768234
12Synaptic vesicle cycle_Homo sapiens_hsa047211.79060043
13Viral myocarditis_Homo sapiens_hsa054161.74754035
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.71156797
15Ribosome_Homo sapiens_hsa030101.69977685
16GABAergic synapse_Homo sapiens_hsa047271.67273238
17MicroRNAs in cancer_Homo sapiens_hsa052061.66383542
18Cell cycle_Homo sapiens_hsa041101.62819290
19Glutamatergic synapse_Homo sapiens_hsa047241.59246374
20Endometrial cancer_Homo sapiens_hsa052131.57844073
21Renal cell carcinoma_Homo sapiens_hsa052111.55683824
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52714173
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52587555
24Chronic myeloid leukemia_Homo sapiens_hsa052201.51926154
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50107668
26Circadian entrainment_Homo sapiens_hsa047131.47567431
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47486262
28RNA transport_Homo sapiens_hsa030131.41219114
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39614678
30Wnt signaling pathway_Homo sapiens_hsa043101.37230367
31Steroid biosynthesis_Homo sapiens_hsa001001.37217962
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.37190862
33Amphetamine addiction_Homo sapiens_hsa050311.36685455
34Cardiac muscle contraction_Homo sapiens_hsa042601.36116801
35DNA replication_Homo sapiens_hsa030301.34584160
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33068701
37Cholinergic synapse_Homo sapiens_hsa047251.29502881
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28580990
39Morphine addiction_Homo sapiens_hsa050321.28403086
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24104552
41Oocyte meiosis_Homo sapiens_hsa041141.20725873
42Shigellosis_Homo sapiens_hsa051311.20479234
43Base excision repair_Homo sapiens_hsa034101.16443196
44Small cell lung cancer_Homo sapiens_hsa052221.14422585
45VEGF signaling pathway_Homo sapiens_hsa043701.13950328
46HTLV-I infection_Homo sapiens_hsa051661.13910827
47ErbB signaling pathway_Homo sapiens_hsa040121.13091718
48Proteoglycans in cancer_Homo sapiens_hsa052051.12653496
49* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12202493
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11852854
51TGF-beta signaling pathway_Homo sapiens_hsa043501.09303039
52Parkinsons disease_Homo sapiens_hsa050121.08721959
53Gap junction_Homo sapiens_hsa045401.07754739
54Pancreatic cancer_Homo sapiens_hsa052121.07657980
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07402541
56Epstein-Barr virus infection_Homo sapiens_hsa051691.07128179
57Adherens junction_Homo sapiens_hsa045201.05668087
58Pathways in cancer_Homo sapiens_hsa052001.04768582
59Melanogenesis_Homo sapiens_hsa049161.03929232
60Glioma_Homo sapiens_hsa052141.03388156
61Tight junction_Homo sapiens_hsa045301.03024246
62mTOR signaling pathway_Homo sapiens_hsa041501.02988142
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99896850
64Biosynthesis of amino acids_Homo sapiens_hsa012300.99891151
65Vibrio cholerae infection_Homo sapiens_hsa051100.98356857
66Viral carcinogenesis_Homo sapiens_hsa052030.98084669
67Long-term potentiation_Homo sapiens_hsa047200.94559024
68Long-term depression_Homo sapiens_hsa047300.91749359
69Non-small cell lung cancer_Homo sapiens_hsa052230.90897844
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89719651
71Dorso-ventral axis formation_Homo sapiens_hsa043200.88772703
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88232730
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87863011
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87106359
75Apoptosis_Homo sapiens_hsa042100.85720689
76Sulfur relay system_Homo sapiens_hsa041220.85654569
77Mismatch repair_Homo sapiens_hsa034300.84583624
78TNF signaling pathway_Homo sapiens_hsa046680.84383212
79Huntingtons disease_Homo sapiens_hsa050160.83375679
80Alcoholism_Homo sapiens_hsa050340.83085059
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82773347
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82634905
83p53 signaling pathway_Homo sapiens_hsa041150.82275758
84Oxidative phosphorylation_Homo sapiens_hsa001900.81965981
85Phototransduction_Homo sapiens_hsa047440.81568340
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81277523
87Taste transduction_Homo sapiens_hsa047420.81276803
88Salmonella infection_Homo sapiens_hsa051320.81194594
89Insulin secretion_Homo sapiens_hsa049110.80896030
90Bladder cancer_Homo sapiens_hsa052190.80632789
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78982151
92Hepatitis B_Homo sapiens_hsa051610.76950765
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76949416
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76698500
95Alzheimers disease_Homo sapiens_hsa050100.75993241
96Estrogen signaling pathway_Homo sapiens_hsa049150.75785581
97T cell receptor signaling pathway_Homo sapiens_hsa046600.75768423
98Herpes simplex infection_Homo sapiens_hsa051680.75523134
99Prion diseases_Homo sapiens_hsa050200.71004359
100Allograft rejection_Homo sapiens_hsa053300.70926297
101cAMP signaling pathway_Homo sapiens_hsa040240.70835190
102Toxoplasmosis_Homo sapiens_hsa051450.70309194
103Endocytosis_Homo sapiens_hsa041440.69878355
104AMPK signaling pathway_Homo sapiens_hsa041520.69466459
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69101169
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68497716
107MAPK signaling pathway_Homo sapiens_hsa040100.68241973
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67842426
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66948896
110Focal adhesion_Homo sapiens_hsa045100.66551248
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66489806
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.65915932
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65858403
114Gastric acid secretion_Homo sapiens_hsa049710.65369477
115B cell receptor signaling pathway_Homo sapiens_hsa046620.64624506
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.64303132
117Legionellosis_Homo sapiens_hsa051340.64023671
118Thyroid cancer_Homo sapiens_hsa052160.63549216
119Prostate cancer_Homo sapiens_hsa052150.63498079
120Chemokine signaling pathway_Homo sapiens_hsa040620.62669608
121Rap1 signaling pathway_Homo sapiens_hsa040150.61679219
122Graft-versus-host disease_Homo sapiens_hsa053320.61087664
123Serotonergic synapse_Homo sapiens_hsa047260.60778556
124Prolactin signaling pathway_Homo sapiens_hsa049170.59599175
125Arginine and proline metabolism_Homo sapiens_hsa003300.58688476
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58349153
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58077650
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.56486923
129Influenza A_Homo sapiens_hsa051640.56009043
130Acute myeloid leukemia_Homo sapiens_hsa052210.55951071
131Choline metabolism in cancer_Homo sapiens_hsa052310.55813973
132Dopaminergic synapse_Homo sapiens_hsa047280.54809934
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.54630224
134Melanoma_Homo sapiens_hsa052180.54609221
135RNA polymerase_Homo sapiens_hsa030200.54475101
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54407325
137Ras signaling pathway_Homo sapiens_hsa040140.53001590
138Oxytocin signaling pathway_Homo sapiens_hsa049210.52798786
139Pertussis_Homo sapiens_hsa051330.52679983
140Systemic lupus erythematosus_Homo sapiens_hsa053220.52210018
141Proteasome_Homo sapiens_hsa030500.50301807
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49310413
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49155673
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.48030412
145Lysine degradation_Homo sapiens_hsa003100.47600754
146Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46017990
147Thyroid hormone synthesis_Homo sapiens_hsa049180.45835336
148Vitamin B6 metabolism_Homo sapiens_hsa007500.43233631
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39519739

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