MARCKSL1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.35679029
2positive regulation of gamma-delta T cell activation (GO:0046645)5.24272506
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.93784114
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.93784114
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.93784114
6modulation by symbiont of host immune response (GO:0052553)4.93784114
7positive regulation by symbiont of host defense response (GO:0052509)4.93784114
8modulation by symbiont of host defense response (GO:0052031)4.93784114
9cellular extravasation (GO:0045123)4.74019096
10macrophage activation involved in immune response (GO:0002281)4.60781928
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.43101108
12response to peptidoglycan (GO:0032494)4.38497673
13regulation of B cell receptor signaling pathway (GO:0050855)4.23563212
14negative regulation of interleukin-12 production (GO:0032695)4.04586563
15regulation of gamma-delta T cell activation (GO:0046643)3.98649857
16detection of external biotic stimulus (GO:0098581)3.96572773
17positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.89990440
18regulation of interferon-beta biosynthetic process (GO:0045357)3.85154753
19neutrophil activation involved in immune response (GO:0002283)3.83491373
20response to muramyl dipeptide (GO:0032495)3.79716275
21macrophage activation (GO:0042116)3.78082230
22regulation of gamma-delta T cell differentiation (GO:0045586)3.72031401
23detection of other organism (GO:0098543)3.71298223
24neutrophil mediated immunity (GO:0002446)3.69404304
25negative regulation of cell killing (GO:0031342)3.63468521
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63468521
27microglial cell activation (GO:0001774)3.60325669
28B cell receptor signaling pathway (GO:0050853)3.50632974
29detection of biotic stimulus (GO:0009595)3.43912783
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43125884
31negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.42910422
32regulation of necroptotic process (GO:0060544)3.42111117
33germinal center formation (GO:0002467)3.36954664
34negative regulation of erythrocyte differentiation (GO:0045647)3.36756655
35response to host immune response (GO:0052572)3.35224710
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.35224710
37production of molecular mediator involved in inflammatory response (GO:0002532)3.29949092
38response to host (GO:0075136)3.29860378
39response to host defenses (GO:0052200)3.29860378
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.29860378
41myeloid cell activation involved in immune response (GO:0002275)3.25239063
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22503563
43neutrophil activation (GO:0042119)3.21476038
44cellular response to ethanol (GO:0071361)3.16148242
45myeloid leukocyte mediated immunity (GO:0002444)3.14405173
46negative regulation of interleukin-8 production (GO:0032717)3.12848850
47histone H3-K36 demethylation (GO:0070544)3.12019507
48regulation of mast cell degranulation (GO:0043304)3.09763566
49regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.09100743
50regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07925947
51respiratory burst (GO:0045730)3.06429641
52detection of bacterium (GO:0016045)3.05306695
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04112394
54granulocyte activation (GO:0036230)3.02601835
55hepatocyte apoptotic process (GO:0097284)3.01708119
56negative regulation of interleukin-6 production (GO:0032715)3.00559018
57embryonic process involved in female pregnancy (GO:0060136)2.98641129
58regulation of myeloid leukocyte mediated immunity (GO:0002886)2.96487661
59regulation of leukocyte degranulation (GO:0043300)2.95625095
60negative regulation of toll-like receptor signaling pathway (GO:0034122)2.93787310
61positive regulation of interferon-alpha production (GO:0032727)2.92940911
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92607824
63negative regulation of lymphocyte mediated immunity (GO:0002707)2.89427928
64regulation of mast cell activation involved in immune response (GO:0033006)2.87467039
65positive regulation of Cdc42 GTPase activity (GO:0043089)2.86173594
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83708909
67negative regulation of T-helper cell differentiation (GO:0045623)2.83529824
68negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83529824
69regulation of interleukin-12 biosynthetic process (GO:0045075)2.83045600
70T-helper 1 type immune response (GO:0042088)2.82756854
71regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80160896
72positive thymic T cell selection (GO:0045059)2.78475802
73positive regulation of B cell differentiation (GO:0045579)2.77488816
74I-kappaB phosphorylation (GO:0007252)2.76395754
75positive regulation of receptor recycling (GO:0001921)2.75398356
76regulation of interferon-alpha production (GO:0032647)2.73733363
77leukocyte aggregation (GO:0070486)2.71761581
78mannose metabolic process (GO:0006013)2.70834875
79antigen processing and presentation of endogenous antigen (GO:0019883)2.69477548
80regulation of T-helper 2 cell differentiation (GO:0045628)2.68458322
81regulation of B cell differentiation (GO:0045577)2.67123551
82negative regulation of T cell mediated immunity (GO:0002710)2.66721773
83defense response to protozoan (GO:0042832)2.65031947
84regulation of macrophage cytokine production (GO:0010935)2.64949682
85regulation of interleukin-6 biosynthetic process (GO:0045408)2.62797157
86regulation of mast cell activation (GO:0033003)2.62538977
87response to interleukin-15 (GO:0070672)2.61140946
88negative regulation of leukocyte mediated immunity (GO:0002704)2.56757448
89leukocyte migration involved in inflammatory response (GO:0002523)2.56038177
90positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.55825585
91positive regulation of cellular amide metabolic process (GO:0034250)2.54815004
92regulation of toll-like receptor signaling pathway (GO:0034121)2.54731666
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53171728
94iron ion import (GO:0097286)2.50049849
95leukocyte degranulation (GO:0043299)2.49810934
96positive regulation of mast cell activation (GO:0033005)2.49228265
97phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.47819686
98myeloid leukocyte activation (GO:0002274)2.47188083
99positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.46811539
100positive T cell selection (GO:0043368)2.46642334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.92638777
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.31209245
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15908998
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03012373
5VDR_21846776_ChIP-Seq_THP-1_Human3.00397218
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.97343772
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.96098121
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.86812520
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82870490
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79510196
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.73442740
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71400819
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.71021534
14VDR_24763502_ChIP-Seq_THP-1_Human2.70417486
15SCL_19346495_ChIP-Seq_HPC-7_Human2.69550043
16MYC_22102868_ChIP-Seq_BL_Human2.47769328
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.40374990
18GATA1_22025678_ChIP-Seq_K562_Human2.37287860
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32799215
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.31672273
21TCF7_22412390_ChIP-Seq_EML_Mouse2.31000382
22RUNX_20019798_ChIP-Seq_JUKART_Human2.30429747
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28918361
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27643042
25SPI1_23127762_ChIP-Seq_K562_Human2.27626881
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.27576480
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.21081244
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.16127800
29MAF_26560356_Chip-Seq_TH1_Human2.15645787
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04651162
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.00950479
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99118391
33SPI1_23547873_ChIP-Seq_NB4_Human1.98537685
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.97716951
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96977365
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.89937435
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.87863258
38KDM2B_26808549_Chip-Seq_DND41_Human1.85446192
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83711529
40MYB_26560356_Chip-Seq_TH1_Human1.83274780
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.83218973
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79951051
43GATA1_19941826_ChIP-Seq_K562_Human1.76258360
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75105917
45VDR_24787735_ChIP-Seq_THP-1_Human1.74803494
46MYB_26560356_Chip-Seq_TH2_Human1.74197425
47UTX_26944678_Chip-Seq_JUKART_Human1.73877389
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64870269
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63502393
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61705894
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61026007
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.50789448
53MAF_26560356_Chip-Seq_TH2_Human1.50733596
54PU_27001747_Chip-Seq_BMDM_Mouse1.47270622
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.46813929
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43951399
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.40749411
58GATA2_19941826_ChIP-Seq_K562_Human1.39903432
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.36592620
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.35131521
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34652377
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32527366
63GATA3_27048872_Chip-Seq_THYMUS_Human1.29417967
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28797096
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26379951
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24452909
67KDM2B_26808549_Chip-Seq_K562_Human1.15802690
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14743785
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14686304
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14665668
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14582689
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12863550
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12206974
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08701074
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.08165760
76NCOR1_26117541_ChIP-Seq_K562_Human1.06047199
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06010447
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05589994
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.05355578
80RACK7_27058665_Chip-Seq_MCF-7_Human1.04936205
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04303569
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04091363
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03788752
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01345184
85GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00672523
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00029664
87LXR_22292898_ChIP-Seq_THP-1_Human0.98621052
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97423034
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97403206
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97366047
91RUNX1_27514584_Chip-Seq_MCF-7_Human0.93682385
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91210608
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90820001
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90820001
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90255412
96GATA3_26560356_Chip-Seq_TH2_Human0.89783600
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87568220
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.85155139
99PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84706653
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84183480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.49526995
2MP0003303_peritoneal_inflammation3.47588416
3MP0003436_decreased_susceptibility_to3.35770091
4MP0000569_abnormal_digit_pigmentation3.06128786
5MP0001835_abnormal_antigen_presentation2.97200454
6MP0008260_abnormal_autophagy2.79902121
7MP0003172_abnormal_lysosome_physiology2.78214315
8MP0005451_abnormal_body_composition2.77084869
9MP0002419_abnormal_innate_immunity2.59007865
10MP0003300_gastrointestinal_ulcer2.47233908
11MP0000685_abnormal_immune_system2.36432417
12MP0002396_abnormal_hematopoietic_system2.32535941
13MP0003828_pulmonary_edema2.29865869
14MP0005076_abnormal_cell_differentiation2.21008630
15MP0001800_abnormal_humoral_immune2.19507248
16MP0005025_abnormal_response_to2.13745689
17MP0003656_abnormal_erythrocyte_physiolo2.00814528
18MP0003191_abnormal_cellular_cholesterol1.98170520
19MP0002723_abnormal_immune_serum1.97161879
20MP0005000_abnormal_immune_tolerance1.96684748
21MP0002452_abnormal_antigen_presenting1.96130417
22MP0002420_abnormal_adaptive_immunity1.94224091
23MP0001819_abnormal_immune_cell1.92689728
24MP0004381_abnormal_hair_follicle1.91141895
25MP0005387_immune_system_phenotype1.90196430
26MP0001790_abnormal_immune_system1.90196430
27MP0004947_skin_inflammation1.86191087
28MP0002405_respiratory_system_inflammati1.81621323
29MP0009278_abnormal_bone_marrow1.81349962
30MP0003763_abnormal_thymus_physiology1.81181787
31MP0005464_abnormal_platelet_physiology1.79012532
32MP0004808_abnormal_hematopoietic_stem1.78836087
33MP0009785_altered_susceptibility_to1.72446444
34MP0002398_abnormal_bone_marrow1.72044263
35MP0003091_abnormal_cell_migration1.69360204
36MP0000015_abnormal_ear_pigmentation1.60767429
37MP0003705_abnormal_hypodermis_morpholog1.59665315
38MP0000716_abnormal_immune_system1.58664188
39MP0004883_abnormal_blood_vessel1.58230628
40MP0001533_abnormal_skeleton_physiology1.57259264
41MP0005397_hematopoietic_system_phenotyp1.51522681
42MP0001545_abnormal_hematopoietic_system1.51522681
43MP0002332_abnormal_exercise_endurance1.50170242
44MP0003221_abnormal_cardiomyocyte_apopto1.47508780
45MP0006082_CNS_inflammation1.47165933
46MP0004510_myositis1.46474044
47MP0002166_altered_tumor_susceptibility1.44458287
48MP0005310_abnormal_salivary_gland1.43455933
49MP0005164_abnormal_response_to1.41833967
50MP0005174_abnormal_tail_pigmentation1.40267986
51MP0002148_abnormal_hypersensitivity_rea1.38535165
52MP0002722_abnormal_immune_system1.36902362
53MP0005671_abnormal_response_to1.35777878
54MP0000689_abnormal_spleen_morphology1.35668899
55MP0002429_abnormal_blood_cell1.32618140
56MP0008057_abnormal_DNA_replication1.31763052
57MP0001845_abnormal_inflammatory_respons1.31692146
58MP0005058_abnormal_lysosome_morphology1.30676509
59MP0010155_abnormal_intestine_physiology1.26302940
60MP0004130_abnormal_muscle_cell1.26100979
61MP0009764_decreased_sensitivity_to1.24935757
62MP0002998_abnormal_bone_remodeling1.24479302
63MP0005083_abnormal_biliary_tract1.21766825
64MP0000858_altered_metastatic_potential1.19412698
65MP0000371_diluted_coat_color1.17473664
66MP0000703_abnormal_thymus_morphology1.16025095
67MP0005409_darkened_coat_color1.15733817
68MP0000465_gastrointestinal_hemorrhage1.15366368
69MP0003566_abnormal_cell_adhesion1.14195366
70MP0004185_abnormal_adipocyte_glucose1.09320664
71MP0000604_amyloidosis1.08622483
72MP0009840_abnormal_foam_cell1.07491200
73MP0002877_abnormal_melanocyte_morpholog1.07092866
74MP0008469_abnormal_protein_level1.06233195
75MP0001851_eye_inflammation1.04084086
76MP0003453_abnormal_keratinocyte_physiol1.02721009
77MP0003866_abnormal_defecation0.97249273
78MP0002009_preneoplasia0.96311267
79MP0002132_abnormal_respiratory_system0.96171261
80MP0005167_abnormal_blood-brain_barrier0.90606076
81MP0001958_emphysema0.90037139
82MP0004233_abnormal_muscle_weight0.88258157
83MP0003329_amyloid_beta_deposits0.87503051
84MP0000249_abnormal_blood_vessel0.86255387
85MP0005621_abnormal_cell_physiology0.83987430
86MP0002006_tumorigenesis0.83031519
87MP0001915_intracranial_hemorrhage0.82230857
88MP0003045_fibrosis0.81254748
89MP0006054_spinal_hemorrhage0.80986505
90MP0003690_abnormal_glial_cell0.76036208
91MP0003448_altered_tumor_morphology0.73604746
92MP0003075_altered_response_to0.73508378
93MP0009115_abnormal_fat_cell0.71893718
94MP0002933_joint_inflammation0.69367878
95MP0001853_heart_inflammation0.67858827
96MP0003183_abnormal_peptide_metabolism0.66662726
97MP0009763_increased_sensitivity_to0.65698064
98MP0009333_abnormal_splenocyte_physiolog0.65597491
99MP0010352_gastrointestinal_tract_polyps0.65249160
100MP0010307_abnormal_tumor_latency0.64567017

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.12081574
2Recurrent abscess formation (HP:0002722)4.87036986
3Eczematoid dermatitis (HP:0000976)4.74033727
4Myositis (HP:0100614)4.30448058
5Orchitis (HP:0100796)4.28408194
6Optic neuritis (HP:0100653)4.03326388
7Retrobulbar optic neuritis (HP:0100654)4.03326388
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.02950445
9Recurrent gram-negative bacterial infections (HP:0005420)3.64134568
10Recurrent fungal infections (HP:0002841)3.59173805
11Abnormality of macrophages (HP:0004311)3.57373971
12Abnormality of the fingertips (HP:0001211)3.52771744
13Gastrointestinal infarctions (HP:0005244)3.49530691
14Spontaneous hematomas (HP:0007420)3.34356420
15Recurrent skin infections (HP:0001581)3.32000473
16Peritonitis (HP:0002586)3.27045157
17Gingivitis (HP:0000230)3.22899070
18Recurrent cutaneous fungal infections (HP:0011370)3.07580448
19Chronic mucocutaneous candidiasis (HP:0002728)3.07580448
20Elevated erythrocyte sedimentation rate (HP:0003565)3.07373867
21Keratoconjunctivitis sicca (HP:0001097)2.97423876
22Mediastinal lymphadenopathy (HP:0100721)2.89893325
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.87652572
24Gingival bleeding (HP:0000225)2.85280492
25Cellulitis (HP:0100658)2.84946180
26Subacute progressive viral hepatitis (HP:0006572)2.80243314
27Stomatitis (HP:0010280)2.79659040
28Arterial thrombosis (HP:0004420)2.77667217
29Colitis (HP:0002583)2.77488199
30Prolonged bleeding time (HP:0003010)2.73857381
31Recurrent viral infections (HP:0004429)2.72715457
32Fatigue (HP:0012378)2.67512031
33T lymphocytopenia (HP:0005403)2.67208984
34Keratoconjunctivitis (HP:0001096)2.64380217
35Epistaxis (HP:0000421)2.63336288
36Meningitis (HP:0001287)2.61711961
37Obstructive lung disease (HP:0006536)2.53007861
38Chronic obstructive pulmonary disease (HP:0006510)2.53007861
39Abnormality of T cell number (HP:0011839)2.49185531
40Inflammation of the large intestine (HP:0002037)2.47946016
41Slow saccadic eye movements (HP:0000514)2.47296157
42Vasculitis (HP:0002633)2.45708098
43Chest pain (HP:0100749)2.44359521
44Hemoptysis (HP:0002105)2.39606420
45Myocardial infarction (HP:0001658)2.37374618
46Increased IgE level (HP:0003212)2.35024960
47Viral hepatitis (HP:0006562)2.34392789
48Gastrointestinal inflammation (HP:0004386)2.34341739
49Encephalitis (HP:0002383)2.25517612
50Spondylolisthesis (HP:0003302)2.21788058
51Abnormality of the peritoneum (HP:0002585)2.21713936
52Broad face (HP:0000283)2.16116473
53Interstitial pulmonary disease (HP:0006530)2.15722076
54Leukocytosis (HP:0001974)2.15557971
55Autoimmune thrombocytopenia (HP:0001973)2.14280477
56Abnormality of the endocardium (HP:0004306)2.14025432
57Amyloidosis (HP:0011034)2.13762845
58Increased cerebral lipofuscin (HP:0011813)2.13685960
59Urticaria (HP:0001025)2.10878777
60Episodic fever (HP:0001954)2.08899429
61Hypochromic anemia (HP:0001931)2.08542131
62Difficulty running (HP:0009046)2.07619337
63Periodontitis (HP:0000704)2.07059980
64Pulmonary infiltrates (HP:0002113)2.04778768
65Anorexia (HP:0002039)2.03411298
66Syringomyelia (HP:0003396)2.03229387
67Spinal cord lesions (HP:0100561)2.03229387
68Pulmonary embolism (HP:0002204)2.01508094
69Increased connective tissue (HP:0009025)1.99686352
70Dislocated radial head (HP:0003083)1.94668192
71Pustule (HP:0200039)1.93917168
72Increased neuronal autofluorescent lipopigment (HP:0002074)1.91383803
73Hematochezia (HP:0002573)1.91353555
74Osteomyelitis (HP:0002754)1.89898702
75Granulocytopenia (HP:0001913)1.89161325
76Hemorrhage of the eye (HP:0011885)1.84834818
77Hypochromic microcytic anemia (HP:0004840)1.82374108
78Abnormal platelet volume (HP:0011876)1.81712510
79Cheilitis (HP:0100825)1.80089749
80Progressive external ophthalmoplegia (HP:0000590)1.79641034
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79628514
82Abnormality of T cells (HP:0002843)1.76037579
83Abnormality of the radial head (HP:0003995)1.75617181
84Micronodular cirrhosis (HP:0001413)1.75297515
85Narrow palate (HP:0000189)1.72637224
86Gangrene (HP:0100758)1.70279581
87Microcytic anemia (HP:0001935)1.68275147
88Onion bulb formation (HP:0003383)1.67714774
89Autoimmune hemolytic anemia (HP:0001890)1.66795881
90Absent frontal sinuses (HP:0002688)1.65525516
91Keratitis (HP:0000491)1.64582294
92Abnormality of the columella (HP:0009929)1.64202340
93Abnormality of the vasculature of the conjunctiva (HP:0008054)1.63416872
94Eosinophilia (HP:0001880)1.63339433
95Increased serum ferritin (HP:0003281)1.63228904
96Abnormality of the pleura (HP:0002103)1.62487385
97Prominent nose (HP:0000448)1.61277764
98Osteolytic defects of the phalanges of the hand (HP:0009771)1.60593869
99Osteolytic defects of the hand bones (HP:0009699)1.60593869
100Acute hepatic failure (HP:0006554)1.59581366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K33.17072344
2RIPK43.14264164
3BLK2.95679139
4IRAK42.27181554
5ERN12.23574861
6TAOK12.18999688
7TRIB32.18935501
8MAP3K142.17234041
9MAP4K12.08656995
10MAP3K32.03098553
11CDK121.98683511
12CSK1.96326613
13TYK21.88443117
14PRPF4B1.74859213
15GRK61.74532336
16MARK21.65905809
17DYRK31.63062807
18ZAP701.61272440
19EEF2K1.54375107
20BTK1.54346510
21IKBKE1.50518737
22MAP3K61.48792395
23MAP3K111.48455777
24JAK31.45059690
25TRPM71.44734433
26FES1.43388420
27MAP3K21.42864332
28EPHB11.42672595
29PIK3CG1.40200138
30ICK1.35104107
31HCK1.34411493
32WNK11.34325347
33AKT31.31427606
34IRAK31.29555334
35IRAK21.27310576
36IRAK11.26592887
37MAP3K11.21659666
38MAP3K71.19948083
39SYK1.17824910
40FGR1.15192304
41SIK11.14580499
42SGK21.13713993
43SGK31.12519919
44MAP3K131.12435862
45CAMK1D1.11111557
46TAOK31.10721677
47RIPK11.08149655
48JAK11.07536186
49TBK11.02420298
50TTN1.01295664
51JAK20.98272901
52PTK60.97897980
53PRKD20.97649887
54TNK20.97400822
55BRD40.93964068
56CDC42BPA0.93909245
57FGFR30.93647999
58RAF10.92648604
59KSR20.89465619
60TAOK20.87720860
61PIM10.87078907
62TGFBR20.85706644
63PKN20.85615251
64YES10.84927383
65NEK90.84543517
66KIT0.80277275
67STK100.78950470
68MATK0.78922722
69LYN0.76147142
70MTOR0.75859339
71FGFR40.75781912
72MAPK110.74238410
73PDPK10.72737279
74MAP2K40.72534834
75LCK0.69793119
76CHUK0.69637986
77TXK0.69401424
78ITK0.68686822
79IKBKB0.68352413
80MARK30.67756064
81MAPK120.66464996
82PRKAA20.66422032
83PDK10.65943435
84PDGFRB0.64382628
85SMG10.63888266
86MAP3K50.63149851
87BMPR20.62272653
88CAMK1G0.62272376
89SGK4940.61370004
90SGK2230.61370004
91HIPK20.60957746
92CSF1R0.60192521
93RPS6KL10.60126881
94RPS6KC10.60126881
95STK110.59158772
96TEC0.58721736
97RPS6KB20.58689381
98MELK0.57762475
99RET0.57175544
100CDK60.54683302

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.49988819
2B cell receptor signaling pathway_Homo sapiens_hsa046622.30792986
3Leishmaniasis_Homo sapiens_hsa051402.18664713
4Acute myeloid leukemia_Homo sapiens_hsa052212.14584595
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98514336
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.88734374
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.86817282
8Non-small cell lung cancer_Homo sapiens_hsa052231.84090848
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79772935
10Tuberculosis_Homo sapiens_hsa051521.76101857
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72000571
12Staphylococcus aureus infection_Homo sapiens_hsa051501.70419114
13Chronic myeloid leukemia_Homo sapiens_hsa052201.69894046
14Measles_Homo sapiens_hsa051621.58637303
15TNF signaling pathway_Homo sapiens_hsa046681.56360650
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55785628
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53558385
18Malaria_Homo sapiens_hsa051441.53167622
19Other glycan degradation_Homo sapiens_hsa005111.51970856
20Toxoplasmosis_Homo sapiens_hsa051451.51384734
21Pancreatic cancer_Homo sapiens_hsa052121.50902359
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46905946
23Hepatitis B_Homo sapiens_hsa051611.42103604
24Influenza A_Homo sapiens_hsa051641.40383578
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.40211835
26T cell receptor signaling pathway_Homo sapiens_hsa046601.39131863
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38834110
28Chemokine signaling pathway_Homo sapiens_hsa040621.37790465
29Dorso-ventral axis formation_Homo sapiens_hsa043201.35742946
30Hepatitis C_Homo sapiens_hsa051601.25853848
31Prolactin signaling pathway_Homo sapiens_hsa049171.24017036
32Platelet activation_Homo sapiens_hsa046111.22022019
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.21013902
34VEGF signaling pathway_Homo sapiens_hsa043701.19866741
35Endometrial cancer_Homo sapiens_hsa052131.18250541
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18180510
37Renal cell carcinoma_Homo sapiens_hsa052111.16385871
38Notch signaling pathway_Homo sapiens_hsa043301.15508895
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.14330168
40FoxO signaling pathway_Homo sapiens_hsa040681.14146685
41mTOR signaling pathway_Homo sapiens_hsa041501.12702605
42Legionellosis_Homo sapiens_hsa051341.11967830
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.09007132
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07377838
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07261999
46Apoptosis_Homo sapiens_hsa042101.05724172
47Insulin resistance_Homo sapiens_hsa049311.03507637
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02952739
49Hematopoietic cell lineage_Homo sapiens_hsa046401.02424488
50Inositol phosphate metabolism_Homo sapiens_hsa005620.99040350
51Herpes simplex infection_Homo sapiens_hsa051680.97961087
52ErbB signaling pathway_Homo sapiens_hsa040120.95585216
53Viral carcinogenesis_Homo sapiens_hsa052030.93197161
54Small cell lung cancer_Homo sapiens_hsa052220.92440641
55Prostate cancer_Homo sapiens_hsa052150.92269528
56Systemic lupus erythematosus_Homo sapiens_hsa053220.90025814
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.88628522
58Lysosome_Homo sapiens_hsa041420.87226966
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85918718
60Choline metabolism in cancer_Homo sapiens_hsa052310.85060541
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83534222
62Bladder cancer_Homo sapiens_hsa052190.83177838
63Pertussis_Homo sapiens_hsa051330.82622645
64Glioma_Homo sapiens_hsa052140.82358310
65Colorectal cancer_Homo sapiens_hsa052100.80688477
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80648739
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80420699
68African trypanosomiasis_Homo sapiens_hsa051430.79664421
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.78912559
70Amoebiasis_Homo sapiens_hsa051460.78714670
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.76611806
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75841858
73GnRH signaling pathway_Homo sapiens_hsa049120.75595346
74HIF-1 signaling pathway_Homo sapiens_hsa040660.74087766
75Type II diabetes mellitus_Homo sapiens_hsa049300.72930927
76Thyroid cancer_Homo sapiens_hsa052160.72472304
77Primary immunodeficiency_Homo sapiens_hsa053400.70161681
78Phagosome_Homo sapiens_hsa041450.70091409
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68444065
80MicroRNAs in cancer_Homo sapiens_hsa052060.68315540
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66697569
82MAPK signaling pathway_Homo sapiens_hsa040100.65188558
83Endocytosis_Homo sapiens_hsa041440.63086208
84Salmonella infection_Homo sapiens_hsa051320.62697445
85Insulin signaling pathway_Homo sapiens_hsa049100.62693596
86Proteoglycans in cancer_Homo sapiens_hsa052050.61693429
87Shigellosis_Homo sapiens_hsa051310.61156240
88Estrogen signaling pathway_Homo sapiens_hsa049150.60661400
89Epstein-Barr virus infection_Homo sapiens_hsa051690.59381501
90HTLV-I infection_Homo sapiens_hsa051660.59190889
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58708483
92Complement and coagulation cascades_Homo sapiens_hsa046100.57698931
93Graft-versus-host disease_Homo sapiens_hsa053320.55979949
94ABC transporters_Homo sapiens_hsa020100.53355782
95Allograft rejection_Homo sapiens_hsa053300.52566831
96Focal adhesion_Homo sapiens_hsa045100.51945730
97Adherens junction_Homo sapiens_hsa045200.51916491
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50173926
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49566315
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.48863417

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