ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.93644631
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.62069566
3	behavioral response to nicotine (GO:0035095)	4.27273348
4	somite development (GO:0061053)	3.91770724
5	sulfation (GO:0051923)	3.78035264
6	indolalkylamine metabolic process (GO:0006586)	3.68731998
7	gamma-aminobutyric acid transport (GO:0015812)	3.60159442
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.58537207
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.58537207
10	NADH dehydrogenase complex assembly (GO:0010257)	3.58537207
11	tryptophan metabolic process (GO:0006568)	3.56126184
12	response to pheromone (GO:0019236)	3.55206861
13	tryptophan catabolic process (GO:0006569)	3.52620332
14	indole-containing compound catabolic process (GO:0042436)	3.52620332
15	indolalkylamine catabolic process (GO:0046218)	3.52620332
16	protein polyglutamylation (GO:0018095)	3.45326911
17	kynurenine metabolic process (GO:0070189)	3.44549387
18	fucose catabolic process (GO:0019317)	3.42636696
19	L-fucose metabolic process (GO:0042354)	3.42636696
20	L-fucose catabolic process (GO:0042355)	3.42636696
21	negative regulation of mast cell activation (GO:0033004)	3.42492005
22	cell proliferation in forebrain (GO:0021846)	3.41822042
23	detection of light stimulus involved in visual perception (GO:0050908)	3.38781040
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.38781040
25	cornea development in camera-type eye (GO:0061303)	3.37710712
26	cellular response to ATP (GO:0071318)	3.36554928
27	protein complex biogenesis (GO:0070271)	3.33073071
28	piRNA metabolic process (GO:0034587)	3.32675454
29	preassembly of GPI anchor in ER membrane (GO:0016254)	3.29726379
30	kidney morphogenesis (GO:0060993)	3.23551429
31	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.14074165
32	negative regulation of telomere maintenance (GO:0032205)	3.11928492
33	regulation of mesoderm development (GO:2000380)	3.09637393
34	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.09564531
35	regulation of glomerulus development (GO:0090192)	3.08556543
36	platelet dense granule organization (GO:0060155)	3.07738638
37	positive regulation of meiosis (GO:0045836)	3.04815750
38	indole-containing compound metabolic process (GO:0042430)	3.01965296
39	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.00793956
40	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.00793956
41	mitochondrial respiratory chain complex assembly (GO:0033108)	2.97813842
42	primary amino compound metabolic process (GO:1901160)	2.97565155
43	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.95783921
44	DNA methylation involved in gamete generation (GO:0043046)	2.95762148
45	serotonin metabolic process (GO:0042428)	2.92359363
46	GPI anchor metabolic process (GO:0006505)	2.83800947
47	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.83686981
48	positive regulation of cAMP-mediated signaling (GO:0043950)	2.82810763
49	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.82714793
50	positive regulation of meiotic cell cycle (GO:0051446)	2.81620982
51	positive regulation of fatty acid transport (GO:2000193)	2.81237819
52	regulation of action potential (GO:0098900)	2.79329663
53	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.78086852
54	mannosylation (GO:0097502)	2.77263588
55	adaptation of signaling pathway (GO:0023058)	2.77237113
56	negative regulation of systemic arterial blood pressure (GO:0003085)	2.77109311
57	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76173345
58	magnesium ion transport (GO:0015693)	2.76052320
59	regulation of meiosis I (GO:0060631)	2.75997874
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.74579989
61	axoneme assembly (GO:0035082)	2.74407854
62	epithelial cilium movement (GO:0003351)	2.69961393
63	positive regulation of glomerulus development (GO:0090193)	2.67421522
64	regulation of neurotransmitter uptake (GO:0051580)	2.67026753
65	synapsis (GO:0007129)	2.66081683
66	pharyngeal system development (GO:0060037)	2.64182330
67	neuronal action potential (GO:0019228)	2.62439405
68	embryonic epithelial tube formation (GO:0001838)	2.60483243
69	replication fork processing (GO:0031297)	2.58270449
70	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.58202155
71	prostate gland growth (GO:0060736)	2.58193830
72	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.57410369
73	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.57410369
74	cellular biogenic amine catabolic process (GO:0042402)	2.57064415
75	amine catabolic process (GO:0009310)	2.57064415
76	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.57020687
77	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.57020687
78	recombinational repair (GO:0000725)	2.55403521
79	double-strand break repair via homologous recombination (GO:0000724)	2.54780877
80	negative regulation of astrocyte differentiation (GO:0048712)	2.54450715
81	pituitary gland development (GO:0021983)	2.50437571
82	thyroid hormone metabolic process (GO:0042403)	2.49459282
83	respiratory chain complex IV assembly (GO:0008535)	2.48863996
84	transepithelial transport (GO:0070633)	2.48723007
85	protein K6-linked ubiquitination (GO:0085020)	2.48484192
86	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.46974852
87	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.46932331
88	dentate gyrus development (GO:0021542)	2.46175250
89	cellular ketone body metabolic process (GO:0046950)	2.44196644
90	photoreceptor cell development (GO:0042461)	2.43749497
91	male meiosis I (GO:0007141)	2.43180678
92	regulation of hippo signaling (GO:0035330)	2.42759664
93	response to lipoprotein particle (GO:0055094)	2.41939540
94	endoderm formation (GO:0001706)	2.41429226
95	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.41001970
96	positive regulation of mitochondrial fission (GO:0090141)	2.40784384
97	aggressive behavior (GO:0002118)	2.40369678
98	positive regulation of icosanoid secretion (GO:0032305)	2.39498073
99	rhodopsin mediated signaling pathway (GO:0016056)	2.39085033
100	epithelial tube formation (GO:0072175)	2.38452773

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.57117499
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.29862778
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.04131139
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.98556864
5	VDR_22108803_ChIP-Seq_LS180_Human	2.76533443
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.71502984
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63077227
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.40316692
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32937859
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22918533
11	FUS_26573619_Chip-Seq_HEK293_Human	2.19262069
12	EWS_26573619_Chip-Seq_HEK293_Human	2.13888270
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.00957446
14	P300_19829295_ChIP-Seq_ESCs_Human	1.98121403
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.95550712
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.94669908
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87596684
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.79409296
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77734610
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.76808697
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.76371541
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69567937
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69436642
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65791034
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65131303
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64663026
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.60952398
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60681773
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.58942825
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51880184
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.51436531
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49902274
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.47417516
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46540693
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.46203810
36	STAT3_23295773_ChIP-Seq_U87_Human	1.45817051
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43916308
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43638148
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43440177
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.40541674
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40541674
42	AR_25329375_ChIP-Seq_VCAP_Human	1.39656694
43	TCF4_23295773_ChIP-Seq_U87_Human	1.39416863
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.39213501
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35898298
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35807914
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35807914
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35593409
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34063551
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33955537
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33799407
52	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.30959401
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30915414
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30915414
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29617043
56	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.29254500
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28836451
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.28791558
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24765765
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24466554
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24235306
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23497608
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23490107
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22768712
65	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.20182184
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18382192
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17473269
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.16954105
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16369035
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16258024
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16202690
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16189447
73	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.15590163
74	NCOR_22424771_ChIP-Seq_293T_Human	1.13593062
75	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13190342
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.12942983
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12312193
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.11284316
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11268239
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11124136
81	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11124136
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10433756
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09189751
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08726981
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08267899
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08119425
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08052296
88	AR_20517297_ChIP-Seq_VCAP_Human	1.07792001
89	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06871208
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06120466
91	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.05345893
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.04774098
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04416205
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02777941
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02164066
96	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.02040012
97	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.01766745
98	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.99501803
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98051973
100	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.97831707

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.52733102
2	MP0005646_abnormal_pituitary_gland	3.39091557
3	MP0008877_abnormal_DNA_methylation	3.20835191
4	MP0002837_dystrophic_cardiac_calcinosis	3.16107107
5	MP0002138_abnormal_hepatobiliary_system	2.71098575
6	MP0003195_calcinosis	2.67606789
7	MP0002102_abnormal_ear_morphology	2.64023476
8	MP0003646_muscle_fatigue	2.46987628
9	MP0006072_abnormal_retinal_apoptosis	2.29091879
10	MP0004885_abnormal_endolymph	2.20479049
11	MP0005551_abnormal_eye_electrophysiolog	2.17840742
12	MP0008872_abnormal_physiological_respon	2.14086597
13	MP0002160_abnormal_reproductive_system	2.08320745
14	MP0003787_abnormal_imprinting	1.95169070
15	MP0001968_abnormal_touch/_nociception	1.95053444
16	MP0000631_abnormal_neuroendocrine_gland	1.92811446
17	MP0005389_reproductive_system_phenotype	1.85646470
18	MP0002876_abnormal_thyroid_physiology	1.85018074
19	MP0003283_abnormal_digestive_organ	1.82115372
20	MP0003011_delayed_dark_adaptation	1.73862575
21	MP0005379_endocrine/exocrine_gland_phen	1.69686576
22	MP0005253_abnormal_eye_physiology	1.66152467
23	MP0004142_abnormal_muscle_tone	1.64247784
24	MP0002272_abnormal_nervous_system	1.62658738
25	MP0004145_abnormal_muscle_electrophysio	1.61894429
26	MP0001485_abnormal_pinna_reflex	1.60960265
27	MP0005084_abnormal_gallbladder_morpholo	1.60013272
28	MP0002736_abnormal_nociception_after	1.58028218
29	MP0009745_abnormal_behavioral_response	1.57377170
30	MP0000372_irregular_coat_pigmentation	1.52858767
31	MP0009046_muscle_twitch	1.52255339
32	MP0002638_abnormal_pupillary_reflex	1.51286921
33	MP0000049_abnormal_middle_ear	1.50447305
34	MP0000383_abnormal_hair_follicle	1.50355439
35	MP0003567_abnormal_fetal_cardiomyocyte	1.37710983
36	MP0002163_abnormal_gland_morphology	1.32449762
37	MP0008875_abnormal_xenobiotic_pharmacok	1.31352823
38	MP0002938_white_spotting	1.29633847
39	MP0003880_abnormal_central_pattern	1.28397360
40	MP0003119_abnormal_digestive_system	1.25735919
41	MP0008789_abnormal_olfactory_epithelium	1.24945408
42	MP0005645_abnormal_hypothalamus_physiol	1.23853760
43	MP0001919_abnormal_reproductive_system	1.23534098
44	MP0004133_heterotaxia	1.22643453
45	MP0001486_abnormal_startle_reflex	1.19369406
46	MP0000013_abnormal_adipose_tissue	1.19073500
47	MP0005410_abnormal_fertilization	1.14873656
48	MP0002064_seizures	1.11221277
49	MP0001986_abnormal_taste_sensitivity	1.08973320
50	MP0000569_abnormal_digit_pigmentation	1.08941757
51	MP0006276_abnormal_autonomic_nervous	1.07706608
52	MP0000613_abnormal_salivary_gland	1.07261199
53	MP0003937_abnormal_limbs/digits/tail_de	1.05121687
54	MP0000427_abnormal_hair_cycle	1.04664622
55	MP0002572_abnormal_emotion/affect_behav	1.01729695
56	MP0003718_maternal_effect	1.01567508
57	MP0005367_renal/urinary_system_phenotyp	1.01511308
58	MP0000516_abnormal_urinary_system	1.01511308
59	MP0002557_abnormal_social/conspecific_i	1.01325929
60	MP0002751_abnormal_autonomic_nervous	1.01243179
61	MP0002653_abnormal_ependyma_morphology	1.00611387
62	MP0005195_abnormal_posterior_eye	0.98545675
63	MP0002234_abnormal_pharynx_morphology	0.98205078
64	MP0001501_abnormal_sleep_pattern	0.97635701
65	MP0004043_abnormal_pH_regulation	0.95729645
66	MP0002928_abnormal_bile_duct	0.95085808
67	MP0002733_abnormal_thermal_nociception	0.94682421
68	MP0008775_abnormal_heart_ventricle	0.94366340
69	MP0001764_abnormal_homeostasis	0.94047486
70	MP0002139_abnormal_hepatobiliary_system	0.92203281
71	MP0008058_abnormal_DNA_repair	0.92137039
72	MP0004134_abnormal_chest_morphology	0.92005647
73	MP0001963_abnormal_hearing_physiology	0.91227844
74	MP0003635_abnormal_synaptic_transmissio	0.91165082
75	MP0001970_abnormal_pain_threshold	0.90768281
76	MP0005174_abnormal_tail_pigmentation	0.89865401
77	MP0005670_abnormal_white_adipose	0.89571101
78	MP0008995_early_reproductive_senescence	0.88954461
79	MP0005171_absent_coat_pigmentation	0.87506573
80	MP0002735_abnormal_chemical_nociception	0.84225597
81	MP0005360_urolithiasis	0.83726288
82	MP0003938_abnormal_ear_development	0.83070661
83	MP0000026_abnormal_inner_ear	0.82074445
84	MP0000230_abnormal_systemic_arterial	0.81983115
85	MP0009053_abnormal_anal_canal	0.81713086
86	MP0005332_abnormal_amino_acid	0.80318175
87	MP0005075_abnormal_melanosome_morpholog	0.79473661
88	MP0002282_abnormal_trachea_morphology	0.78541080
89	MP0010678_abnormal_skin_adnexa	0.77957991
90	MP0003121_genomic_imprinting	0.77240330
91	MP0003786_premature_aging	0.77040248
92	MP0000647_abnormal_sebaceous_gland	0.76620696
93	MP0001905_abnormal_dopamine_level	0.76461877
94	MP0009697_abnormal_copulation	0.75932171
95	MP0003698_abnormal_male_reproductive	0.75821781
96	MP0003724_increased_susceptibility_to	0.75745519
97	MP0002063_abnormal_learning/memory/cond	0.74585477
98	MP0002184_abnormal_innervation	0.74419111
99	MP0000653_abnormal_sex_gland	0.74053971
100	MP0002752_abnormal_somatic_nervous	0.73048345

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.92422928
2	Congenital stationary night blindness (HP:0007642)	3.83106372
3	Pancreatic fibrosis (HP:0100732)	3.59671549
4	True hermaphroditism (HP:0010459)	3.54304145
5	Nephronophthisis (HP:0000090)	3.44388840
6	Pendular nystagmus (HP:0012043)	3.32604855
7	Abnormality of midbrain morphology (HP:0002418)	3.31221308
8	Molar tooth sign on MRI (HP:0002419)	3.31221308
9	Abolished electroretinogram (ERG) (HP:0000550)	3.24860594
10	Abnormality of the renal cortex (HP:0011035)	3.24443926
11	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.05707170
12	Increased corneal curvature (HP:0100692)	2.99883001
13	Keratoconus (HP:0000563)	2.99883001
14	Abnormality of the renal medulla (HP:0100957)	2.95594749
15	Methylmalonic acidemia (HP:0002912)	2.90968209
16	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.89754183
17	Short 1st metacarpal (HP:0010034)	2.89754183
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.80130272
19	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.66814354
20	Abnormality of the nasal septum (HP:0000419)	2.56919719
21	Renal cortical cysts (HP:0000803)	2.54224963
22	Methylmalonic aciduria (HP:0012120)	2.54166270
23	Hyperglycinemia (HP:0002154)	2.53994789
24	Abnormality of the middle phalanges of the toes (HP:0010183)	2.53637927
25	Polydipsia (HP:0001959)	2.53264630
26	Abnormal drinking behavior (HP:0030082)	2.53264630
27	Hypoplasia of the uterus (HP:0000013)	2.52650748
28	Hyperalaninemia (HP:0003348)	2.52242404
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52242404
30	Abnormality of alanine metabolism (HP:0010916)	2.52242404
31	Abnormality of the 1st metacarpal (HP:0010009)	2.52127579
32	Type II lissencephaly (HP:0007260)	2.50213140
33	Tubular atrophy (HP:0000092)	2.50044449
34	Attenuation of retinal blood vessels (HP:0007843)	2.48923787
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.48342404
36	Aplasia/hypoplasia of the uterus (HP:0008684)	2.47721784
37	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.45831231
38	Cystic liver disease (HP:0006706)	2.42133950
39	Gaze-evoked nystagmus (HP:0000640)	2.41682231
40	Decreased central vision (HP:0007663)	2.41467576
41	Short hallux (HP:0010109)	2.38984373
42	Chorioretinal atrophy (HP:0000533)	2.38286050
43	Medial flaring of the eyebrow (HP:0010747)	2.36859653
44	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.34759273
45	Congenital sensorineural hearing impairment (HP:0008527)	2.34631483
46	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.33156605
47	Progressive cerebellar ataxia (HP:0002073)	2.25669739
48	Genetic anticipation (HP:0003743)	2.22598186
49	Abnormality of the renal collecting system (HP:0004742)	2.20947841
50	Stomach cancer (HP:0012126)	2.16122126
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.15491135
52	Congenital, generalized hypertrichosis (HP:0004540)	2.14041173
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.13270671
54	Asplenia (HP:0001746)	2.12294211
55	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.09431568
56	Hypothermia (HP:0002045)	2.09399901
57	Sclerocornea (HP:0000647)	2.09007574
58	Hyperventilation (HP:0002883)	2.07757892
59	Furrowed tongue (HP:0000221)	2.05967326
60	Chronic hepatic failure (HP:0100626)	2.05270712
61	Abnormal biliary tract physiology (HP:0012439)	2.04654883
62	Bile duct proliferation (HP:0001408)	2.04654883
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.04511898
64	Absent/shortened dynein arms (HP:0200106)	2.04511898
65	Adrenal hypoplasia (HP:0000835)	2.03107581
66	Acute necrotizing encephalopathy (HP:0006965)	2.02780208
67	Hemiparesis (HP:0001269)	2.01016686
68	Short phalanx of the thumb (HP:0009660)	1.99075043
69	Bony spicule pigmentary retinopathy (HP:0007737)	1.98052913
70	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.96039723
71	3-Methylglutaconic aciduria (HP:0003535)	1.94519737
72	Polyuria (HP:0000103)	1.94367721
73	Progressive macrocephaly (HP:0004481)	1.93979388
74	Male pseudohermaphroditism (HP:0000037)	1.91999846
75	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.91385901
76	Increased CSF lactate (HP:0002490)	1.90784874
77	Synostosis involving the elbow (HP:0003938)	1.90509263
78	Humeroradial synostosis (HP:0003041)	1.90509263
79	Morphological abnormality of the middle ear (HP:0008609)	1.89721884
80	Mitochondrial inheritance (HP:0001427)	1.89296933
81	Severe muscular hypotonia (HP:0006829)	1.88386901
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.88123877
83	Small hand (HP:0200055)	1.87202004
84	Congenital hepatic fibrosis (HP:0002612)	1.85756565
85	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84922450
86	Stenosis of the external auditory canal (HP:0000402)	1.82817813
87	Absent thumb (HP:0009777)	1.81887122
88	Ectopic kidney (HP:0000086)	1.80816012
89	Adactyly (HP:0009776)	1.80189483
90	Hematochezia (HP:0002573)	1.77510566
91	Decreased circulating renin level (HP:0003351)	1.75922975
92	Ketosis (HP:0001946)	1.75777541
93	Abnormality of vitamin B metabolism (HP:0004340)	1.74996820
94	Acute encephalopathy (HP:0006846)	1.74734625
95	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.74610109
96	Hypoplasia of the fovea (HP:0007750)	1.74610109
97	Abnormality of DNA repair (HP:0003254)	1.74220558
98	Abnormality of serine family amino acid metabolism (HP:0010894)	1.74189145
99	Abnormality of glycine metabolism (HP:0010895)	1.74189145
100	Synostosis of carpal bones (HP:0005048)	1.74087881

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.15972573
2	GRK1	3.37167194
3	ADRBK2	3.11483536
4	MAP4K2	3.09625582
5	TLK1	2.97045911
6	ZAK	2.67065514
7	BMPR1B	2.63699540
8	PINK1	2.44003570
9	WNK3	2.26626819
10	NUAK1	2.23338031
11	PLK2	1.97086549
12	INSRR	1.96937082
13	MAPK13	1.91261846
14	ACVR1B	1.83950454
15	TAOK3	1.74307979
16	MAP3K4	1.57344636
17	STK16	1.48305034
18	MAPKAPK3	1.48053924
19	WNK4	1.40882571
20	FLT3	1.38329167
21	OXSR1	1.37306257
22	TNIK	1.33486078
23	STK39	1.32628459
24	CASK	1.23353690
25	DAPK2	1.20796752
26	PRKCE	1.18219986
27	EIF2AK3	1.16594882
28	VRK1	1.10162352
29	STK38L	1.10082889
30	PHKG2	1.09324907
31	PHKG1	1.09324907
32	CSNK1G2	1.08252782
33	MAP2K7	1.06968289
34	TRIM28	1.06793413
35	PTK2B	1.06434168
36	CSNK1G1	1.04108567
37	TIE1	1.01976580
38	MKNK2	1.01441484
39	TXK	0.96637702
40	PRKCG	0.96568383
41	CSNK1G3	0.95337482
42	MST4	0.93120166
43	MUSK	0.90382028
44	MAP2K6	0.89218763
45	DYRK2	0.88111138
46	PAK3	0.88080312
47	PRKCI	0.87232227
48	ADRBK1	0.87147881
49	BRSK2	0.86179267
50	ERBB3	0.86098045
51	FGFR2	0.83773711
52	BCKDK	0.80316458
53	TEC	0.78577059
54	IKBKB	0.78354389
55	TAF1	0.72676707
56	CSNK1A1L	0.72606117
57	PLK3	0.70449205
58	GRK5	0.70437046
59	NTRK3	0.69202657
60	FER	0.68472603
61	KIT	0.66890361
62	MAPKAPK5	0.66861786
63	PRKCQ	0.60434088
64	RPS6KA5	0.59495351
65	CSNK1A1	0.58798804
66	VRK2	0.58332665
67	CAMK2A	0.56493400
68	EPHA4	0.55860725
69	PRKAA1	0.55307576
70	CAMKK2	0.54232559
71	MKNK1	0.53516315
72	TGFBR1	0.53160739
73	PRKACA	0.52200500
74	MARK1	0.47363939
75	BCR	0.44843046
76	MAP2K1	0.44831514
77	PIK3CA	0.44141906
78	TNK2	0.43516904
79	STK3	0.43114623
80	EPHA3	0.42361732
81	PLK1	0.42174471
82	PKN1	0.41719403
83	NLK	0.40168128
84	PRKCA	0.39869046
85	ATR	0.39495726
86	PLK4	0.38928267
87	CSNK1D	0.38864218
88	SGK2	0.37956051
89	SYK	0.37468619
90	PRKCZ	0.35619985
91	IRAK1	0.35316535
92	DAPK1	0.35288418
93	ITK	0.34933865
94	CDK9	0.34701732
95	LYN	0.34459361
96	ABL1	0.31977537
97	IGF1R	0.29985316
98	GRK7	0.29804488
99	OBSCN	0.28721015
100	CAMK1	0.27578775

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.02744594
2	Phototransduction_Homo sapiens_hsa04744	2.74418923
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.63122545
4	Sulfur metabolism_Homo sapiens_hsa00920	2.51154283
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.21526301
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.10813010
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10321660
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.05567406
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.04979985
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.03849091
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.95924300
12	Protein export_Homo sapiens_hsa03060	1.92148899
13	Nicotine addiction_Homo sapiens_hsa05033	1.90229977
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.89194544
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84384861
16	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.81464375
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.81314848
18	Butanoate metabolism_Homo sapiens_hsa00650	1.81184985
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.78597970
20	Homologous recombination_Homo sapiens_hsa03440	1.73105834
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.72160287
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.63813052
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.58056069
24	Caffeine metabolism_Homo sapiens_hsa00232	1.48736181
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46343629
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.46071800
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.45379318
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.44666403
29	Retinol metabolism_Homo sapiens_hsa00830	1.41549903
30	Basal transcription factors_Homo sapiens_hsa03022	1.40969186
31	RNA polymerase_Homo sapiens_hsa03020	1.39596878
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.37759030
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.35849453
34	RNA degradation_Homo sapiens_hsa03018	1.32526573
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31242924
36	One carbon pool by folate_Homo sapiens_hsa00670	1.30518430
37	Olfactory transduction_Homo sapiens_hsa04740	1.20554593
38	Propanoate metabolism_Homo sapiens_hsa00640	1.16542633
39	Morphine addiction_Homo sapiens_hsa05032	1.12535723
40	Taste transduction_Homo sapiens_hsa04742	1.10439381
41	Glycerolipid metabolism_Homo sapiens_hsa00561	1.09136087
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.08986753
43	Parkinsons disease_Homo sapiens_hsa05012	1.08533696
44	Insulin secretion_Homo sapiens_hsa04911	1.08334765
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.06574355
46	Asthma_Homo sapiens_hsa05310	1.04235672
47	Regulation of autophagy_Homo sapiens_hsa04140	1.03967846
48	Peroxisome_Homo sapiens_hsa04146	1.02856267
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94288017
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92440725
51	Circadian entrainment_Homo sapiens_hsa04713	0.91886734
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.89318099
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.88275870
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87857112
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85409966
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84188216
57	Histidine metabolism_Homo sapiens_hsa00340	0.80214256
58	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80063639
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77975808
60	Salivary secretion_Homo sapiens_hsa04970	0.77789101
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.77378549
62	Alzheimers disease_Homo sapiens_hsa05010	0.74552288
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73718474
64	Serotonergic synapse_Homo sapiens_hsa04726	0.71739680
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.71647426
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70678967
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.67744662
68	GABAergic synapse_Homo sapiens_hsa04727	0.67580159
69	Purine metabolism_Homo sapiens_hsa00230	0.64453217
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63733661
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.63670181
72	Huntingtons disease_Homo sapiens_hsa05016	0.63172217
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.61202595
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59627237
75	Metabolic pathways_Homo sapiens_hsa01100	0.59325183
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.58044400
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.57614467
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.57557600
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56983278
80	ABC transporters_Homo sapiens_hsa02010	0.54815246
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54527526
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54198763
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.52899858
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51162783
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50821748
86	Renin secretion_Homo sapiens_hsa04924	0.50069545
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.46417845
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44146112
89	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.44086390
90	Proteasome_Homo sapiens_hsa03050	0.43879712
91	Sulfur relay system_Homo sapiens_hsa04122	0.43535290
92	Mineral absorption_Homo sapiens_hsa04978	0.42878128
93	Non-homologous end-joining_Homo sapiens_hsa03450	0.42623979
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.40768972
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.40046662
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39199224
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38279507
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37206629
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36659121
100	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36576848

MARCKSL1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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