MARCO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)6.43197984
2modulation by symbiont of host defense response (GO:0052031)6.43197984
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.43197984
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.43197984
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.43197984
6modulation by symbiont of host immune response (GO:0052553)6.43197984
7positive regulation of heterotypic cell-cell adhesion (GO:0034116)6.00596213
8hydrogen peroxide biosynthetic process (GO:0050665)5.55465534
9positive regulation of chemokine biosynthetic process (GO:0045080)5.45616057
10cellular response to zinc ion (GO:0071294)5.44227726
11glycosphingolipid catabolic process (GO:0046479)5.29210046
12response to peptidoglycan (GO:0032494)4.95738156
13respiratory burst (GO:0045730)4.93664367
14reactive oxygen species biosynthetic process (GO:1903409)4.90160691
15cellular response to thyroid hormone stimulus (GO:0097067)4.89975547
16macrophage activation involved in immune response (GO:0002281)4.89214889
17oligosaccharide catabolic process (GO:0009313)4.80098386
18neutrophil activation involved in immune response (GO:0002283)4.78511403
19lipopolysaccharide-mediated signaling pathway (GO:0031663)4.78082892
20glycolipid catabolic process (GO:0019377)4.74799143
21positive regulation of cellular amide metabolic process (GO:0034250)4.73111495
22cellular extravasation (GO:0045123)4.72560022
23regulation of chemokine biosynthetic process (GO:0045073)4.51832973
24amino sugar catabolic process (GO:0046348)4.48569680
25positive regulation of heat generation (GO:0031652)4.44441731
26cellular response to cadmium ion (GO:0071276)4.42492710
27detection of molecule of bacterial origin (GO:0032490)4.38785760
28regulation of podosome assembly (GO:0071801)4.38214225
29immunoglobulin mediated immune response (GO:0016064)4.34948653
30regulation of fever generation (GO:0031620)4.33720357
31ceramide catabolic process (GO:0046514)4.22494821
32regulation of macrophage chemotaxis (GO:0010758)4.20040182
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18850465
34response to host immune response (GO:0052572)4.14540305
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.14540305
36positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.02924375
37positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.02410804
38response to thyroid hormone (GO:0097066)3.98784471
39superoxide anion generation (GO:0042554)3.97275470
40positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.93857374
41positive regulation of gamma-delta T cell activation (GO:0046645)3.93263381
42negative regulation of interleukin-12 production (GO:0032695)3.89420831
43production of molecular mediator involved in inflammatory response (GO:0002532)3.89230417
44barbed-end actin filament capping (GO:0051016)3.87769516
45fat-soluble vitamin biosynthetic process (GO:0042362)3.83804155
46surfactant homeostasis (GO:0043129)3.83662664
47regulation of heterotypic cell-cell adhesion (GO:0034114)3.81652194
48peptide catabolic process (GO:0043171)3.81627467
49positive regulation of mast cell degranulation (GO:0043306)3.74272170
50positive regulation of mast cell activation involved in immune response (GO:0033008)3.74272170
51complement activation, alternative pathway (GO:0006957)3.72530455
52response to host (GO:0075136)3.71995216
53response to host defenses (GO:0052200)3.71995216
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.71995216
55microglial cell activation (GO:0001774)3.65110253
56granulocyte activation (GO:0036230)3.64074010
57eosinophil chemotaxis (GO:0048245)3.58606709
58regulation of cholesterol storage (GO:0010885)3.54858489
59positive regulation of bone remodeling (GO:0046852)3.52379097
60positive regulation of bone resorption (GO:0045780)3.52379097
61leukocyte aggregation (GO:0070486)3.50488094
62macrophage activation (GO:0042116)3.49570286
63low-density lipoprotein particle clearance (GO:0034383)3.44969898
64positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.43776853
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.42303478
66regulation of integrin activation (GO:0033623)3.42034815
67regulation of vitamin D biosynthetic process (GO:0060556)3.41826952
68positive regulation of interferon-alpha production (GO:0032727)3.41090448
69regulation of heat generation (GO:0031650)3.40175090
70myeloid cell activation involved in immune response (GO:0002275)3.37077591
71neutrophil activation (GO:0042119)3.36378494
72detection of external biotic stimulus (GO:0098581)3.35828494
73negative regulation of lipid storage (GO:0010888)3.32261196
74aldehyde catabolic process (GO:0046185)3.31858258
75regulation of superoxide anion generation (GO:0032928)3.31845343
76positive regulation of mast cell activation (GO:0033005)3.30564442
77iron ion import (GO:0097286)3.28164721
78positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.26154044
79eosinophil migration (GO:0072677)3.25304210
80plasma lipoprotein particle clearance (GO:0034381)3.23276504
81membrane lipid catabolic process (GO:0046466)3.22857773
82monocyte chemotaxis (GO:0002548)3.22378809
83macrophage differentiation (GO:0030225)3.21555992
84positive regulation of humoral immune response (GO:0002922)3.21074737
85sphingolipid catabolic process (GO:0030149)3.20147935
86regulation of interferon-alpha production (GO:0032647)3.19503109
87positive regulation of cholesterol efflux (GO:0010875)3.17307291
88B cell mediated immunity (GO:0019724)3.14892362
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13317873
90negative regulation of cell killing (GO:0031342)3.13317873
91peptidyl-glutamic acid carboxylation (GO:0017187)3.12229552
92protein carboxylation (GO:0018214)3.12229552
93phagosome maturation (GO:0090382)3.11449700
94T-helper 1 type immune response (GO:0042088)3.11138412
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.11131934
96myeloid dendritic cell differentiation (GO:0043011)3.10146219
97response to magnesium ion (GO:0032026)3.09693715
98N-acetylneuraminate metabolic process (GO:0006054)3.09064434
99regulation of membrane protein ectodomain proteolysis (GO:0051043)3.08286698
100negative regulation of nitric oxide biosynthetic process (GO:0045019)3.07643153
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05996095
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05996095
103cellular response to ethanol (GO:0071361)3.05521472
104interferon-gamma-mediated signaling pathway (GO:0060333)3.05433817
105neutrophil chemotaxis (GO:0030593)3.04928108
106positive regulation of leukocyte degranulation (GO:0043302)3.04815461
107granulocyte chemotaxis (GO:0071621)3.04131509
108regulation of interleukin-6 biosynthetic process (GO:0045408)3.02909665
109regulation of myeloid leukocyte mediated immunity (GO:0002886)3.01276934
110regulation of vitamin metabolic process (GO:0030656)2.99365873
111regulation of mast cell degranulation (GO:0043304)2.99140623
112acute-phase response (GO:0006953)2.98051605
113neutrophil migration (GO:1990266)2.96733734
114keratan sulfate catabolic process (GO:0042340)2.96270458
115detection of other organism (GO:0098543)2.95977776
116regulation of cytokine secretion involved in immune response (GO:0002739)2.95194448
117regulation of leukocyte degranulation (GO:0043300)2.94546386
118positive regulation of triglyceride lipase activity (GO:0061365)2.94321036
119positive regulation of lipoprotein lipase activity (GO:0051006)2.94321036
120regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94012927
121positive regulation of acute inflammatory response (GO:0002675)2.93392685
122regulation of mononuclear cell migration (GO:0071675)2.92357432
123* apoptotic cell clearance (GO:0043277)2.92148352
124granulocyte migration (GO:0097530)2.92088007
125regulation of interferon-beta biosynthetic process (GO:0045357)2.91515525
126positive regulation of tissue remodeling (GO:0034105)2.90969521
127detection of biotic stimulus (GO:0009595)2.90649805
128regulation of gamma-delta T cell activation (GO:0046643)2.90121189
129response to manganese ion (GO:0010042)2.88732740
130positive regulation of nitric oxide biosynthetic process (GO:0045429)2.87265030
131positive regulation of monocyte chemotaxis (GO:0090026)2.86550137
132positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.86354396
133pinocytosis (GO:0006907)2.84192353
134regulation of monocyte differentiation (GO:0045655)2.82779562
135intracellular pH reduction (GO:0051452)2.82621825
136regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.81879337
137phospholipid efflux (GO:0033700)2.81366294
138detection of bacterium (GO:0016045)2.80523224
139cellular response to type I interferon (GO:0071357)2.80506085
140type I interferon signaling pathway (GO:0060337)2.80506085
141myeloid dendritic cell activation (GO:0001773)2.79391816
142lymphocyte chemotaxis (GO:0048247)2.78622493
143antigen processing and presentation of endogenous antigen (GO:0019883)2.78498413
144regulation of cholesterol esterification (GO:0010872)2.78431255
145response to type I interferon (GO:0034340)2.78331850
146regulation of mast cell activation involved in immune response (GO:0033006)2.78235635
147chemical homeostasis within a tissue (GO:0048875)2.78039530
148regulation of interleukin-8 biosynthetic process (GO:0045414)2.77852510
149positive regulation of chemokine production (GO:0032722)2.77569911
150positive regulation of antigen processing and presentation (GO:0002579)2.76705105
151positive regulation of blood coagulation (GO:0030194)2.75094563
152positive regulation of hemostasis (GO:1900048)2.75094563
153negative regulation of myeloid cell apoptotic process (GO:0033033)2.74506629
154decidualization (GO:0046697)2.74466779
155germinal center formation (GO:0002467)2.74305216
156cytokine secretion (GO:0050663)2.74232890
157leukocyte cell-cell adhesion (GO:0007159)2.72806254
158positive regulation of phagocytosis (GO:0050766)2.72783772
159regulation of hypersensitivity (GO:0002883)2.71942484
160regulation of antigen processing and presentation (GO:0002577)2.71621928
161pH reduction (GO:0045851)2.71263369
162glucosamine-containing compound catabolic process (GO:1901072)2.70917766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.14930235
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.98307099
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.29132465
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.40480794
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.97187313
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.95810315
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72069696
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40008525
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.37956265
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10124272
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.03292653
12RXR_22158963_ChIP-Seq_LIVER_Mouse3.01651822
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.85816201
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.71890465
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69642340
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.65460105
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.57916395
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.51415344
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46753369
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45108490
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.34749512
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29129897
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25199851
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22287881
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.17080214
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13801214
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03747990
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89888513
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.85445568
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83232460
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83116185
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80737198
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.76680896
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.69232887
35VDR_24787735_ChIP-Seq_THP-1_Human1.58662209
36SPI1_23547873_ChIP-Seq_NB4_Human1.53220679
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53008696
38CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52650891
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52095018
40* VDR_24763502_ChIP-Seq_THP-1_Human1.48951593
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46379742
42RUNX_20019798_ChIP-Seq_JUKART_Human1.46297527
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43877568
44SPI1_23127762_ChIP-Seq_K562_Human1.43456228
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42410992
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38477102
47PU_27001747_Chip-Seq_BMDM_Mouse1.37157408
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36926218
49GATA1_22025678_ChIP-Seq_K562_Human1.35765684
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32720580
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32397143
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27028679
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.23968628
54MYB_26560356_Chip-Seq_TH2_Human1.21300517
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19440164
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14473616
57GATA1_19941826_ChIP-Seq_K562_Human1.14468408
58SCL_19346495_ChIP-Seq_HPC-7_Human1.14424214
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12750022
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12102028
61MAF_26560356_Chip-Seq_TH1_Human1.11660400
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10971200
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10447865
64STAT1_20625510_ChIP-Seq_HELA_Human1.10387522
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.09950415
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08906732
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.07705015
68TCF7_22412390_ChIP-Seq_EML_Mouse1.07121356
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05424668
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.04956235
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04576119
72BCL6_27268052_Chip-Seq_Bcells_Human1.04504562
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02951896
74GATA2_19941826_ChIP-Seq_K562_Human1.02104113
75KDM2B_26808549_Chip-Seq_DND41_Human1.01514066
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00987672
77TFEB_21752829_ChIP-Seq_HELA_Human1.00843627
78SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99712372
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98328029
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98328029
81MYB_26560356_Chip-Seq_TH1_Human0.97840457
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97233897
83CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96955763
84NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95865479
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95395759
86GATA3_27048872_Chip-Seq_THYMUS_Human0.94913372
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94669732
88* SPI1_20517297_ChIP-Seq_HL60_Human0.93733232
89* BCOR_27268052_Chip-Seq_Bcells_Human0.93548055
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93212449
91CLOCK_20551151_ChIP-Seq_293T_Human0.93094344
92VDR_21846776_ChIP-Seq_THP-1_Human0.92543669
93GATA3_26560356_Chip-Seq_TH2_Human0.92435696
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92337815
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91512593
96LXR_22292898_ChIP-Seq_THP-1_Human0.91201591
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.90798973
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90690833
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.89163285
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88358410
101ELK3_25401928_ChIP-Seq_HUVEC_Human0.87035360
102UTX_26944678_Chip-Seq_JUKART_Human0.86665928
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85022792
104EGR1_19032775_ChIP-ChIP_M12_Human0.80960578
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80904997
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80507695
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80464362
108SOX2_20726797_ChIP-Seq_SW620_Human0.80131954
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80030611
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.79827668
111KDM2B_26808549_Chip-Seq_K562_Human0.78958834
112RACK7_27058665_Chip-Seq_MCF-7_Human0.78575122
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74713020
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72917324
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72646626
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71786584
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70114828
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68151183
119MAF_26560356_Chip-Seq_TH2_Human0.67153261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to3.62590097
2MP0003436_decreased_susceptibility_to3.61784064
3MP0003724_increased_susceptibility_to3.29356769
4MP0001835_abnormal_antigen_presentation3.28858762
5MP0005058_abnormal_lysosome_morphology3.18692131
6MP0003195_calcinosis3.09696775
7* MP0002419_abnormal_innate_immunity3.08321183
8MP0003303_peritoneal_inflammation2.95599586
9MP0009840_abnormal_foam_cell2.92523649
10MP0003191_abnormal_cellular_cholesterol2.87940402
11MP0005083_abnormal_biliary_tract2.85072462
12MP0002139_abnormal_hepatobiliary_system2.67960516
13* MP0005025_abnormal_response_to2.64387328
14MP0005387_immune_system_phenotype2.57752478
15MP0001790_abnormal_immune_system2.57752478
16MP0002148_abnormal_hypersensitivity_rea2.55927350
17MP0005000_abnormal_immune_tolerance2.53324236
18MP0004510_myositis2.52653773
19MP0005360_urolithiasis2.31585833
20MP0006082_CNS_inflammation2.29436296
21MP0009764_decreased_sensitivity_to2.17063321
22MP0003075_altered_response_to2.15804874
23* MP0002452_abnormal_antigen_presenting2.11789189
24MP0003806_abnormal_nucleotide_metabolis2.09981791
25MP0005464_abnormal_platelet_physiology2.09635033
26MP0000685_abnormal_immune_system2.02952958
27MP0001533_abnormal_skeleton_physiology2.02639802
28MP0004947_skin_inflammation2.00823670
29* MP0001800_abnormal_humoral_immune1.92900518
30* MP0002723_abnormal_immune_serum1.92249712
31MP0003300_gastrointestinal_ulcer1.90216351
32MP0008469_abnormal_protein_level1.89401986
33MP0003329_amyloid_beta_deposits1.88231978
34MP0005167_abnormal_blood-brain_barrier1.77739828
35MP0003172_abnormal_lysosome_physiology1.77265351
36MP0009278_abnormal_bone_marrow1.75911088
37MP0005085_abnormal_gallbladder_physiolo1.74789225
38MP0002006_tumorigenesis1.73399843
39MP0005451_abnormal_body_composition1.70260289
40MP0005365_abnormal_bile_salt1.70240656
41* MP0001819_abnormal_immune_cell1.69344380
42* MP0002420_abnormal_adaptive_immunity1.68810130
43* MP0001845_abnormal_inflammatory_respons1.68742926
44MP0003828_pulmonary_edema1.67302791
45MP0000604_amyloidosis1.62200050
46MP0003186_abnormal_redox_activity1.52254632
47MP0003646_muscle_fatigue1.49166665
48MP0004883_abnormal_blood_vessel1.45376125
49MP0002405_respiratory_system_inflammati1.42561174
50MP0003448_altered_tumor_morphology1.42264514
51MP0005166_decreased_susceptibility_to1.41889341
52MP0002998_abnormal_bone_remodeling1.40626123
53MP0002138_abnormal_hepatobiliary_system1.34808461
54MP0004782_abnormal_surfactant_physiolog1.34755042
55MP0002332_abnormal_exercise_endurance1.33541244
56MP0000343_altered_response_to1.31238226
57MP0000858_altered_metastatic_potential1.31174193
58MP0003656_abnormal_erythrocyte_physiolo1.29765473
59MP0005671_abnormal_response_to1.27723031
60MP0003252_abnormal_bile_duct1.25576689
61MP0000920_abnormal_myelination1.25474067
62MP0002837_dystrophic_cardiac_calcinosis1.21895752
63MP0004130_abnormal_muscle_cell1.16138366
64MP0002254_reproductive_system_inflammat1.15651483
65MP0003705_abnormal_hypodermis_morpholog1.14644525
66MP0003453_abnormal_keratinocyte_physiol1.14424739
67MP0003690_abnormal_glial_cell1.14078710
68MP0009333_abnormal_splenocyte_physiolog1.12474888
69* MP0009763_increased_sensitivity_to1.11731816
70MP0008004_abnormal_stomach_pH1.11316959
71MP0005319_abnormal_enzyme/_coenzyme1.10338547
72MP0000716_abnormal_immune_system1.10280002
73MP0000609_abnormal_liver_physiology1.09992407
74MP0010329_abnormal_lipoprotein_level1.08242449
75MP0005584_abnormal_enzyme/coenzyme_acti1.07739228
76MP0001958_emphysema1.03926876
77MP0005164_abnormal_response_to1.03367141
78MP0005076_abnormal_cell_differentiation0.99208223
79MP0003183_abnormal_peptide_metabolism0.96949496
80MP0002166_altered_tumor_susceptibility0.94542743
81MP0003795_abnormal_bone_structure0.93894063
82MP0010155_abnormal_intestine_physiology0.93101593
83MP0005397_hematopoietic_system_phenotyp0.92901983
84MP0001545_abnormal_hematopoietic_system0.92901983
85MP0005023_abnormal_wound_healing0.92526931
86MP0001853_heart_inflammation0.91518229
87MP0005257_abnormal_intraocular_pressure0.91501906
88* MP0000689_abnormal_spleen_morphology0.89734840
89MP0003566_abnormal_cell_adhesion0.89275699
90MP0001851_eye_inflammation0.87875844
91MP0002398_abnormal_bone_marrow0.87628436
92MP0005535_abnormal_body_temperature0.87484591
93MP0008875_abnormal_xenobiotic_pharmacok0.87428056
94MP0005390_skeleton_phenotype0.86978323
95MP0005595_abnormal_vascular_smooth0.86446967
96MP0001542_abnormal_bone_strength0.86086930
97MP0002429_abnormal_blood_cell0.85765342
98MP0002277_abnormal_respiratory_mucosa0.84760464
99MP0003091_abnormal_cell_migration0.84341364
100MP0005647_abnormal_sex_gland0.84174348
101MP0004858_abnormal_nervous_system0.82695822
102MP0004019_abnormal_vitamin_homeostasis0.82680778
103MP0002118_abnormal_lipid_homeostasis0.82621399
104MP0006054_spinal_hemorrhage0.82544066
105MP0003279_aneurysm0.82137148
106MP0000569_abnormal_digit_pigmentation0.82075105
107MP0008438_abnormal_cutaneous_collagen0.80777746
108MP0000249_abnormal_blood_vessel0.78469899
109MP0000598_abnormal_liver_morphology0.78237101
110MP0005332_abnormal_amino_acid0.78114636
111MP0003634_abnormal_glial_cell0.77239582
112MP0005165_increased_susceptibility_to0.77069112
113MP0008874_decreased_physiological_sensi0.75816481
114MP0005310_abnormal_salivary_gland0.75553647
115MP0002168_other_aberrant_phenotype0.75429503
116MP0002933_joint_inflammation0.74940342
117MP0009765_abnormal_xenobiotic_induced0.74431111
118MP0000767_abnormal_smooth_muscle0.73154242
119MP0002722_abnormal_immune_system0.72760845
120MP0002133_abnormal_respiratory_system0.72449097
121MP0005388_respiratory_system_phenotype0.72449097
122MP0008873_increased_physiological_sensi0.72433509
123MP0008260_abnormal_autophagy0.72127407
124MP0001849_ear_inflammation0.70770448
125MP0002136_abnormal_kidney_physiology0.69322225
126MP0002090_abnormal_vision0.66755368
127MP0002896_abnormal_bone_mineralization0.66382494
128MP0000465_gastrointestinal_hemorrhage0.63057977

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)8.34972018
2Abnormality of glycosphingolipid metabolism (HP:0004343)8.34972018
3Abnormality of glycolipid metabolism (HP:0010969)8.34972018
4Recurrent gram-negative bacterial infections (HP:0005420)7.69553137
5Recurrent abscess formation (HP:0002722)7.08778740
6Eczematoid dermatitis (HP:0000976)6.72429575
7Recurrent bacterial skin infections (HP:0005406)6.63937153
8Systemic lupus erythematosus (HP:0002725)5.98922341
9Autoimmune thrombocytopenia (HP:0001973)5.58627772
10Glomerulonephritis (HP:0000099)4.89489636
11Abnormality of macrophages (HP:0004311)4.71368447
12Mediastinal lymphadenopathy (HP:0100721)4.53387894
13Axonal loss (HP:0003447)4.30298769
14Gingivitis (HP:0000230)4.28371504
15Joint hemorrhage (HP:0005261)4.08984433
16Complement deficiency (HP:0004431)3.94063914
17Periodontitis (HP:0000704)3.91363882
18Neurofibrillary tangles (HP:0002185)3.88319415
19Recurrent skin infections (HP:0001581)3.87573958
20Vacuolated lymphocytes (HP:0001922)3.65410550
21Mutism (HP:0002300)3.63381923
22Abnormality of complement system (HP:0005339)3.60272092
23Pustule (HP:0200039)3.53167227
24Prolonged partial thromboplastin time (HP:0003645)3.49173175
25Elevated erythrocyte sedimentation rate (HP:0003565)3.39789874
26Deep venous thrombosis (HP:0002625)3.38508514
27Thick nail (HP:0001805)3.33165587
28Nephritis (HP:0000123)3.31189979
29Abnormality of aromatic amino acid family metabolism (HP:0004338)3.15220911
30Urticaria (HP:0001025)3.09667146
31Gingival bleeding (HP:0000225)3.07619846
32Xanthomatosis (HP:0000991)3.07537199
33Obstructive lung disease (HP:0006536)3.06036536
34Chronic obstructive pulmonary disease (HP:0006510)3.06036536
35Cellulitis (HP:0100658)3.04135958
36Abnormality of the common coagulation pathway (HP:0010990)3.02298123
37Metaphyseal irregularity (HP:0003025)2.96763466
38Menorrhagia (HP:0000132)2.96423761
39Retinal atrophy (HP:0001105)2.91667403
40Nausea (HP:0002018)2.89495019
41Increased cerebral lipofuscin (HP:0011813)2.88223091
42Increased IgM level (HP:0003496)2.87916425
43Myocardial infarction (HP:0001658)2.86227456
44Vasculitis (HP:0002633)2.81270595
45Recurrent fungal infections (HP:0002841)2.80349006
46Neuronal loss in central nervous system (HP:0002529)2.78683419
47Cerebral inclusion bodies (HP:0100314)2.76258346
48Diminished motivation (HP:0000745)2.72705341
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.70528417
50Amyloidosis (HP:0011034)2.69384802
51Peritonitis (HP:0002586)2.69306020
52Recurrent viral infections (HP:0004429)2.69273740
53Nuclear cataract (HP:0100018)2.68590371
54Apathy (HP:0000741)2.68211298
55Dysostosis multiplex (HP:0000943)2.66235996
56Purpura (HP:0000979)2.65058375
57Upper motor neuron abnormality (HP:0002127)2.61968627
58Esophageal varix (HP:0002040)2.58714193
59Tetraparesis (HP:0002273)2.58481860
60Abnormality of the vasculature of the conjunctiva (HP:0008054)2.57989959
61Stomatitis (HP:0010280)2.57523287
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.51768511
63Osteolytic defects of the hand bones (HP:0009699)2.51768511
64Chronic otitis media (HP:0000389)2.50257924
65Interstitial pulmonary disease (HP:0006530)2.45647863
66Spontaneous hematomas (HP:0007420)2.45594700
67Epistaxis (HP:0000421)2.41321873
68Abnormality of the nasal mucosa (HP:0000433)2.40881859
69Orchitis (HP:0100796)2.40312149
70Nasal polyposis (HP:0100582)2.38654567
71Abnormality of the periventricular white matter (HP:0002518)2.38480932
72Malnutrition (HP:0004395)2.37883422
73IgM deficiency (HP:0002850)2.36944670
74Progressive neurologic deterioration (HP:0002344)2.35072201
75Gastrointestinal infarctions (HP:0005244)2.33849073
76Epidermoid cyst (HP:0200040)2.31808436
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28120049
78Prostate neoplasm (HP:0100787)2.27226829
79Intrahepatic cholestasis (HP:0001406)2.26942583
80Multiple enchondromatosis (HP:0005701)2.20527894
81Myositis (HP:0100614)2.20483786
82Petechiae (HP:0000967)2.19605848
83Conjunctival telangiectasia (HP:0000524)2.18628722
84Premature loss of primary teeth (HP:0006323)2.17336071
85Asymmetric septal hypertrophy (HP:0001670)2.16931711
86Prolonged bleeding time (HP:0003010)2.15044007
87Agnosia (HP:0010524)2.14544028
88Peripheral demyelination (HP:0011096)2.14037101
89Hypercholesterolemia (HP:0003124)2.13831685
90Osteomyelitis (HP:0002754)2.13789185
91Hepatosplenomegaly (HP:0001433)2.13720846
92Hematochezia (HP:0002573)2.12373558
93Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12338473
94Inappropriate behavior (HP:0000719)2.10851973
95Prolonged neonatal jaundice (HP:0006579)2.10740393
96Dementia (HP:0000726)2.08474827
97Pathologic fracture (HP:0002756)2.08206736
98Supranuclear gaze palsy (HP:0000605)2.06274105
99Optic neuritis (HP:0100653)2.05659248
100Retrobulbar optic neuritis (HP:0100654)2.05659248
101Neoplasm of head and neck (HP:0012288)2.03978983
102Esophageal neoplasm (HP:0100751)2.03978983
103Abnormality of transition element cation homeostasis (HP:0011030)2.00642339
104Disinhibition (HP:0000734)1.99895672
105Abnormality of the lumbar spine (HP:0100712)1.99870338
106Mucopolysacchariduria (HP:0008155)1.99748732
107Urinary glycosaminoglycan excretion (HP:0003541)1.99748732
108Recurrent pneumonia (HP:0006532)1.99540756
109Loss of speech (HP:0002371)1.98475745
110Meningitis (HP:0001287)1.97814297
111Hyperlipoproteinemia (HP:0010980)1.97792576
112Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97734134
113Segmental peripheral demyelination/remyelination (HP:0003481)1.95656213
114Increased CSF protein (HP:0002922)1.95328788
115Abnormality of purine metabolism (HP:0004352)1.95012164
116Pulmonary infiltrates (HP:0002113)1.93617297
117Thoracic kyphosis (HP:0002942)1.92100864
118Leukocytosis (HP:0001974)1.91390969
119Hemoptysis (HP:0002105)1.91362615
120Personality changes (HP:0000751)1.90936564
121Joint swelling (HP:0001386)1.89755984
122Bone pain (HP:0002653)1.88341189
123Mitral stenosis (HP:0001718)1.87769469
124Progressive visual loss (HP:0000529)1.85225811
125Protuberant abdomen (HP:0001538)1.85173693
126Increased serum ferritin (HP:0003281)1.84411331
127Pulmonary embolism (HP:0002204)1.83978821
128Hemorrhage of the eye (HP:0011885)1.82253561
129Restrictive lung disease (HP:0002091)1.81806746
130Abnormality of iron homeostasis (HP:0011031)1.80797463
131Thin bony cortex (HP:0002753)1.80698809
132Basal ganglia calcification (HP:0002135)1.80684278
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80222765
134Abnormality of polysaccharide metabolism (HP:0011012)1.80222765
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80222765
136Thrombophlebitis (HP:0004418)1.79865784
137Skin nodule (HP:0200036)1.77423813
138Vertebral compression fractures (HP:0002953)1.73968751
139Hyperventilation (HP:0002883)1.71972390
140Tubulointerstitial fibrosis (HP:0005576)1.71220251
141Polycythemia (HP:0001901)1.67922016
142Hypergammaglobulinemia (HP:0010702)1.66913545
143Cardiomegaly (HP:0001640)1.65488835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.11887188
2MAP3K143.88150609
3ERN13.37319070
4TYK22.95702444
5NME22.95569588
6BLK2.85320960
7MAP4K12.81954414
8FGR2.78164155
9TBK12.60774805
10CSK2.57798675
11JAK32.54132708
12RIPK12.52112214
13IRAK32.48873637
14MST1R2.39613966
15PBK2.02122015
16IKBKE1.97765626
17IRAK41.97402541
18MAP3K31.89596708
19DDR21.88824873
20MAP3K131.86829237
21CAMK1D1.80096230
22JAK11.79347220
23PRPF4B1.77523284
24MAP2K31.74818577
25TXK1.73771106
26MAP3K111.67487875
27CSF1R1.63415322
28FGFR41.53244135
29TAOK31.52663134
30TAOK21.49492768
31DAPK21.48357813
32CDC42BPA1.48319852
33IKBKB1.46488926
34KIT1.32603606
35ZAP701.31539685
36HCK1.31003286
37FES1.30891888
38JAK21.30305703
39CAMKK21.29359570
40STK101.25922784
41TAOK11.25064039
42BMX1.21087286
43ACVR1B1.17543897
44LYN1.15153627
45SYK1.12393102
46NEK91.11790867
47CAMK1G1.10781441
48MET1.06539980
49ABL21.03539020
50MATK1.02349129
51TESK10.98871309
52LCK0.97368733
53YES10.93744477
54TESK20.93312102
55EGFR0.93241741
56TTN0.92436440
57TGFBR20.91292415
58RPS6KA20.91121680
59CLK10.87672846
60CHUK0.84531504
61KSR20.82692834
62ERBB40.82342762
63PAK40.81993102
64ADRBK20.81034324
65DMPK0.79779366
66BMPR20.79297575
67LIMK10.78524721
68TGFBR10.77655180
69MAPK150.77300566
70EPHB10.77137800
71PDPK10.75575457
72MAP3K60.75088492
73NTRK10.72636437
74FYN0.72618857
75EPHA30.72365795
76PRKCD0.70762883
77MAPK120.70444284
78FLT30.70411050
79ADRBK10.67783695
80MAP2K60.66000242
81TRIB30.63916794
82PTK60.63785258
83EPHB20.63075487
84PDK10.62810091
85FGFR30.62708202
86LRRK20.62591088
87PRKCH0.62189682
88KDR0.61995557
89MARK30.60774433
90CDK40.60265199
91PIM20.60088815
92DAPK30.59100153
93RPS6KA40.57722981
94TNK20.57472097
95EIF2AK20.56902692
96MAPK70.55636732
97BTK0.54061837
98MARK20.53225123
99IGF1R0.52919705
100ABL10.52721654
101IRAK20.52285205
102INSR0.50828269
103MOS0.50060078
104FRK0.48806722
105IRAK10.48138684
106PRKCQ0.46954607
107GRK60.45575594
108MAP3K50.45172010
109STK30.44501125
110ARAF0.44287980
111PKN20.43180415
112GRK50.41523383
113SGK30.41176513
114GRK70.40184889
115RPS6KA60.39385804
116DAPK10.38033242
117LATS20.37941021
118RPS6KL10.37249704
119RPS6KC10.37249704
120PDGFRB0.37096981
121PDK20.36814529
122MAP3K80.35675971
123CAMKK10.33729254
124PIM10.33705337
125PRKACG0.33489709
126ITK0.33105911
127MAPK40.32853215
128PIK3CG0.31763967
129GSK3A0.31450989
130MAP3K10.31376665
131MAPK110.30645289
132EIF2AK10.30014347
133SIK10.29976648
134SRC0.29678480
135BCKDK0.29385967
136ALK0.27012950
137MAP3K100.26928671
138STK40.25952923
139PRKG20.25928853

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.64884973
2Leishmaniasis_Homo sapiens_hsa051403.20953829
3Graft-versus-host disease_Homo sapiens_hsa053323.17559975
4Legionellosis_Homo sapiens_hsa051342.89163987
5Malaria_Homo sapiens_hsa051442.62921991
6Complement and coagulation cascades_Homo sapiens_hsa046102.60747228
7Pertussis_Homo sapiens_hsa051332.50627174
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23226416
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15121506
10African trypanosomiasis_Homo sapiens_hsa051432.15029759
11Osteoclast differentiation_Homo sapiens_hsa043802.04408398
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.02929122
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.98319654
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.96158461
15Tuberculosis_Homo sapiens_hsa051521.87958572
16Rheumatoid arthritis_Homo sapiens_hsa053231.77248436
17Type I diabetes mellitus_Homo sapiens_hsa049401.73755606
18Steroid biosynthesis_Homo sapiens_hsa001001.70256643
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69666890
20Salmonella infection_Homo sapiens_hsa051321.64843609
21Autoimmune thyroid disease_Homo sapiens_hsa053201.60274307
22TNF signaling pathway_Homo sapiens_hsa046681.54771947
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54235340
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48829503
25Asthma_Homo sapiens_hsa053101.47665102
26Lysosome_Homo sapiens_hsa041421.46323271
27Hematopoietic cell lineage_Homo sapiens_hsa046401.46201666
28Folate biosynthesis_Homo sapiens_hsa007901.45277828
29Prion diseases_Homo sapiens_hsa050201.43512527
30* Phagosome_Homo sapiens_hsa041451.41483498
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36078729
32Sulfur relay system_Homo sapiens_hsa041221.35938974
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33748915
34Allograft rejection_Homo sapiens_hsa053301.31925459
35Measles_Homo sapiens_hsa051621.31268440
36Nitrogen metabolism_Homo sapiens_hsa009101.24704204
37Influenza A_Homo sapiens_hsa051641.24003444
38B cell receptor signaling pathway_Homo sapiens_hsa046621.20125745
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19714008
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17958767
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11825429
42Chemokine signaling pathway_Homo sapiens_hsa040621.08977737
43Arginine biosynthesis_Homo sapiens_hsa002201.07175181
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03082837
45Other glycan degradation_Homo sapiens_hsa005111.02771554
46Amoebiasis_Homo sapiens_hsa051461.02609106
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02404924
48Herpes simplex infection_Homo sapiens_hsa051681.00274255
49Caffeine metabolism_Homo sapiens_hsa002320.99782964
50Toxoplasmosis_Homo sapiens_hsa051450.99735602
51Fructose and mannose metabolism_Homo sapiens_hsa000510.95525492
52Vibrio cholerae infection_Homo sapiens_hsa051100.91870551
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91031550
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.88621619
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88167821
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.86785369
57PPAR signaling pathway_Homo sapiens_hsa033200.82632145
58Hepatitis C_Homo sapiens_hsa051600.82454939
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82230513
60Galactose metabolism_Homo sapiens_hsa000520.80661026
61Bladder cancer_Homo sapiens_hsa052190.80503123
62Shigellosis_Homo sapiens_hsa051310.80383553
63Antigen processing and presentation_Homo sapiens_hsa046120.79704659
64Peroxisome_Homo sapiens_hsa041460.78935577
65Histidine metabolism_Homo sapiens_hsa003400.78521032
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75017899
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73750642
68Apoptosis_Homo sapiens_hsa042100.73214104
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72573738
70Sphingolipid metabolism_Homo sapiens_hsa006000.72322160
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.67536101
72Fatty acid metabolism_Homo sapiens_hsa012120.65993671
73Phenylalanine metabolism_Homo sapiens_hsa003600.62996424
74Type II diabetes mellitus_Homo sapiens_hsa049300.59502799
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58656449
76Fatty acid degradation_Homo sapiens_hsa000710.57409053
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.57161387
78Fatty acid biosynthesis_Homo sapiens_hsa000610.56139187
79Hepatitis B_Homo sapiens_hsa051610.54948331
80beta-Alanine metabolism_Homo sapiens_hsa004100.54670197
81ABC transporters_Homo sapiens_hsa020100.54579053
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.54176905
83Insulin resistance_Homo sapiens_hsa049310.53698124
84Tryptophan metabolism_Homo sapiens_hsa003800.53017175
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49581565
86Sulfur metabolism_Homo sapiens_hsa009200.46019125
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.45522626
88Platelet activation_Homo sapiens_hsa046110.43021746
89Synaptic vesicle cycle_Homo sapiens_hsa047210.42150950
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42076152
91Arachidonic acid metabolism_Homo sapiens_hsa005900.40514950
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39305601
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.38921489
94Chemical carcinogenesis_Homo sapiens_hsa052040.34512942
95Starch and sucrose metabolism_Homo sapiens_hsa005000.33947689
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32688056
97Pentose phosphate pathway_Homo sapiens_hsa000300.32143406
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32119373
99Fatty acid elongation_Homo sapiens_hsa000620.31893466
100Endocytosis_Homo sapiens_hsa041440.30863281
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30693530
102Systemic lupus erythematosus_Homo sapiens_hsa053220.30001065
103T cell receptor signaling pathway_Homo sapiens_hsa046600.29982414
104VEGF signaling pathway_Homo sapiens_hsa043700.29922795
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29070412
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.28715541
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27272558
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26116570
109Acute myeloid leukemia_Homo sapiens_hsa052210.25748507
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25298654
111Bile secretion_Homo sapiens_hsa049760.25142267
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24937353
113Renin-angiotensin system_Homo sapiens_hsa046140.24303922
114Mineral absorption_Homo sapiens_hsa049780.23511874
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.22621609
116Vitamin digestion and absorption_Homo sapiens_hsa049770.21463787
117Viral myocarditis_Homo sapiens_hsa054160.20604791
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19518271
119GnRH signaling pathway_Homo sapiens_hsa049120.19173354
120Notch signaling pathway_Homo sapiens_hsa043300.18902189
121HIF-1 signaling pathway_Homo sapiens_hsa040660.17172295
122Tyrosine metabolism_Homo sapiens_hsa003500.12958545
123Collecting duct acid secretion_Homo sapiens_hsa049660.12195135

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