MARK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.93065309
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.89409672
3locomotory exploration behavior (GO:0035641)5.66652409
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.39704958
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.37796807
6vocalization behavior (GO:0071625)5.26336288
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12672049
8synaptic vesicle exocytosis (GO:0016079)5.08904697
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.06419344
10pyrimidine nucleobase catabolic process (GO:0006208)4.96745330
11glutamate secretion (GO:0014047)4.93875065
12regulation of synaptic vesicle exocytosis (GO:2000300)4.91067614
13layer formation in cerebral cortex (GO:0021819)4.75433373
14protein localization to synapse (GO:0035418)4.69530493
15regulation of glutamate receptor signaling pathway (GO:1900449)4.68685907
16neuron cell-cell adhesion (GO:0007158)4.50273097
17regulation of synapse structural plasticity (GO:0051823)4.44736067
18exploration behavior (GO:0035640)4.37571198
19dendritic spine morphogenesis (GO:0060997)4.31462713
20regulation of synaptic vesicle transport (GO:1902803)4.22101413
21neurotransmitter secretion (GO:0007269)4.20824948
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16365253
23regulation of neuronal synaptic plasticity (GO:0048168)4.15489983
24nucleobase catabolic process (GO:0046113)4.12083683
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.11509074
26neuronal action potential propagation (GO:0019227)4.10011694
27neurotransmitter-gated ion channel clustering (GO:0072578)4.03934310
28synaptic transmission, glutamatergic (GO:0035249)3.83856943
29regulation of dendritic spine morphogenesis (GO:0061001)3.74929871
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70772564
31neuron recognition (GO:0008038)3.70667693
32proline transport (GO:0015824)3.66872472
33glutamate receptor signaling pathway (GO:0007215)3.65336643
34gamma-aminobutyric acid transport (GO:0015812)3.65040548
35activation of protein kinase A activity (GO:0034199)3.63621600
36neuron-neuron synaptic transmission (GO:0007270)3.63515985
37axonal fasciculation (GO:0007413)3.63319589
38neuromuscular process controlling balance (GO:0050885)3.60656855
39positive regulation of membrane potential (GO:0045838)3.59871831
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59677946
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59577213
42dendrite morphogenesis (GO:0048813)3.58738696
43positive regulation of synapse maturation (GO:0090129)3.55232789
44long-term memory (GO:0007616)3.54857029
45cell migration in hindbrain (GO:0021535)3.51853904
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.50054270
47postsynaptic membrane organization (GO:0001941)3.46740615
48auditory behavior (GO:0031223)3.46382069
49transmission of nerve impulse (GO:0019226)3.37116841
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36066595
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35301328
52regulation of postsynaptic membrane potential (GO:0060078)3.34872286
53neurotransmitter transport (GO:0006836)3.32708274
54regulation of synaptic plasticity (GO:0048167)3.31201228
55neuronal ion channel clustering (GO:0045161)3.31060745
56regulation of neurotransmitter secretion (GO:0046928)3.27440856
57prepulse inhibition (GO:0060134)3.26218348
58cellular potassium ion homeostasis (GO:0030007)3.25369762
59cerebellar Purkinje cell differentiation (GO:0021702)3.19945064
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.18541300
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13749024
62positive regulation of neurotransmitter transport (GO:0051590)3.13134103
63response to auditory stimulus (GO:0010996)3.12748950
64long-term synaptic potentiation (GO:0060291)3.12341452
65positive regulation of neurotransmitter secretion (GO:0001956)3.12224464
66presynaptic membrane assembly (GO:0097105)3.11047205
67regulation of dendritic spine development (GO:0060998)3.10672613
68cell communication by electrical coupling (GO:0010644)3.10471788
69mechanosensory behavior (GO:0007638)3.07773957
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07545320
71synaptic vesicle endocytosis (GO:0048488)3.06903305
72regulation of neurotransmitter levels (GO:0001505)3.06346833
73startle response (GO:0001964)3.06227585
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04214533
75regulation of neurotransmitter transport (GO:0051588)3.03942048
76innervation (GO:0060384)3.03638187
77regulation of vesicle fusion (GO:0031338)3.03310281
78sodium ion export (GO:0071436)3.02813100
79dendritic spine organization (GO:0097061)3.02678095
80vesicle transport along microtubule (GO:0047496)3.02288302
81behavioral response to nicotine (GO:0035095)3.02085020
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99256863
83positive regulation of dendritic spine morphogenesis (GO:0061003)2.98921085
84membrane hyperpolarization (GO:0060081)2.98559711
85positive regulation of dendritic spine development (GO:0060999)2.98122974
86neuromuscular process (GO:0050905)2.97028050
87central nervous system projection neuron axonogenesis (GO:0021952)2.96797946
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96324297
89synapse assembly (GO:0007416)2.95864524
90G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95813550
91positive regulation of synapse assembly (GO:0051965)2.95657715
92detection of calcium ion (GO:0005513)2.95587151
93neuromuscular process controlling posture (GO:0050884)2.93999704
94presynaptic membrane organization (GO:0097090)2.93693081
95establishment of nucleus localization (GO:0040023)2.91530711
96cerebral cortex radially oriented cell migration (GO:0021799)2.91464879
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90665568
98cerebellar granule cell differentiation (GO:0021707)2.90317635
99membrane depolarization (GO:0051899)2.89742302
100membrane depolarization during action potential (GO:0086010)2.89041171
101synapse organization (GO:0050808)2.88977701
102learning (GO:0007612)2.86081945
103glycine transport (GO:0015816)2.85167464
104cerebellar Purkinje cell layer development (GO:0021680)2.84789480
105organelle transport along microtubule (GO:0072384)2.83889465
106nonmotile primary cilium assembly (GO:0035058)2.83085381
107positive regulation of synaptic transmission (GO:0050806)2.83059330
108behavioral defense response (GO:0002209)2.82725210
109behavioral fear response (GO:0001662)2.82725210
110limb bud formation (GO:0060174)2.82136196
111retinal ganglion cell axon guidance (GO:0031290)2.81014758
112adult walking behavior (GO:0007628)2.80879735
113establishment of mitochondrion localization (GO:0051654)2.78532846
114atrial cardiac muscle cell action potential (GO:0086014)2.70997723
115cochlea development (GO:0090102)2.65506441
116calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.63136851
117negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62758140
118regulation of respiratory system process (GO:0044065)2.61427756
119central nervous system neuron axonogenesis (GO:0021955)2.59106974
120glycosphingolipid biosynthetic process (GO:0006688)2.57505277
121C4-dicarboxylate transport (GO:0015740)2.57474965
122neuronal action potential (GO:0019228)2.55248015
123short-term memory (GO:0007614)2.51905710
124negative regulation of dendrite development (GO:2000171)2.50759280
125regulation of synapse assembly (GO:0051963)2.50452003
126righting reflex (GO:0060013)2.47028795
127hindbrain development (GO:0030902)2.46430817
128hippocampus development (GO:0021766)2.40237814
129protein localization to cilium (GO:0061512)2.38722519
130regulation of action potential (GO:0098900)2.37267536
131forebrain neuron differentiation (GO:0021879)2.36479413
132regulation of feeding behavior (GO:0060259)2.34654700
133inner ear receptor stereocilium organization (GO:0060122)2.34545220
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.33880648
135neuromuscular synaptic transmission (GO:0007274)2.33016644
136behavioral response to ethanol (GO:0048149)2.32517817
137adult behavior (GO:0030534)2.31786029
138retina layer formation (GO:0010842)2.31211351
139action potential (GO:0001508)2.30712418
140positive regulation of amino acid transport (GO:0051957)2.28562315
141cerebellum development (GO:0021549)2.21724149
142protein polyglutamylation (GO:0018095)2.21135516
143serotonin metabolic process (GO:0042428)2.20946613
144olfactory bulb development (GO:0021772)2.20292233
145cerebral cortex cell migration (GO:0021795)2.19770344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72273819
2GBX2_23144817_ChIP-Seq_PC3_Human3.24697314
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12206035
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11996417
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03354496
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84634630
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84634630
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72600968
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.71313304
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.65115263
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57852109
12REST_21632747_ChIP-Seq_MESCs_Mouse2.56307701
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55914663
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51285240
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50358813
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49333638
17DROSHA_22980978_ChIP-Seq_HELA_Human2.48712013
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.36685137
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33723089
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.32699853
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.32027331
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.28963047
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28226393
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23703788
25FUS_26573619_Chip-Seq_HEK293_Human2.20867686
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.10972153
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09861028
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08519786
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07302750
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05016950
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96848750
32AR_21572438_ChIP-Seq_LNCaP_Human1.92113892
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89484609
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88947293
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81821144
36EWS_26573619_Chip-Seq_HEK293_Human1.76399957
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73977272
38VDR_22108803_ChIP-Seq_LS180_Human1.72766802
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.71088192
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68818262
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54180024
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53075976
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50878759
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47275991
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47007772
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.45917948
47ZNF274_21170338_ChIP-Seq_K562_Hela1.45017063
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.44162421
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41536772
50* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40739479
51* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40739479
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37784328
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37428747
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36896724
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36832406
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36267504
57TAF15_26573619_Chip-Seq_HEK293_Human1.34818107
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34320955
59* RING1B_27294783_Chip-Seq_NPCs_Mouse1.33083085
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32364488
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31775203
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28546187
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28544483
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28419513
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.26612762
66* NANOG_18555785_Chip-Seq_ESCs_Mouse1.25716189
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24479379
68KDM2B_26808549_Chip-Seq_K562_Human1.24148172
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22920803
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.22240528
71* AR_19668381_ChIP-Seq_PC3_Human1.21766622
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21163947
73* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20834783
74BCAT_22108803_ChIP-Seq_LS180_Human1.19579293
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19128757
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19044191
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.18765376
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18280887
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17183812
80ER_23166858_ChIP-Seq_MCF-7_Human1.13958348
81* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13717697
82STAT3_23295773_ChIP-Seq_U87_Human1.13303128
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13226768
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12745410
85P300_19829295_ChIP-Seq_ESCs_Human1.12432645
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11987524
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.11004695
88AR_25329375_ChIP-Seq_VCAP_Human1.09938493
89SOX9_26525672_Chip-Seq_HEART_Mouse1.09405977
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09391146
91* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09367114
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09260495
93CBP_20019798_ChIP-Seq_JUKART_Human1.09260495
94* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09162510
95* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09110811
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08861081
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07554952
98AHR_22903824_ChIP-Seq_MCF-7_Human1.07084554
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06950971
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06722425
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06662703
102* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06430996
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.06361643
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05517364
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05156184
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.04526666
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.03662334
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03100961
109* P53_22387025_ChIP-Seq_ESCs_Mouse1.02712638
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02651688
111ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02230588
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01240509
113KDM2B_26808549_Chip-Seq_REH_Human1.00747216
114TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00660042
115RNF2_27304074_Chip-Seq_NSC_Mouse1.00481358
116* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99571899
117TCF4_23295773_ChIP-Seq_U87_Human0.96244966
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.95320083
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95249864
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.94828955
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94044482
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94015947
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93154624
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.91309407
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90725807
126* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90158535
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89612936
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89510232
129* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89421707
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.89343166
131TP53_16413492_ChIP-PET_HCT116_Human0.87927550
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87646092
133RUNX2_22187159_ChIP-Seq_PCA_Human0.87326294
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86901129
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.86819248
136CTCF_27219007_Chip-Seq_Bcells_Human0.86681918
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85984006
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85819060
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.85589073
140IGF1R_20145208_ChIP-Seq_DFB_Human0.85323018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.27674980
2MP0003880_abnormal_central_pattern4.25771385
3MP0003635_abnormal_synaptic_transmissio3.98141672
4MP0004270_analgesia3.85144562
5MP0002063_abnormal_learning/memory/cond3.20497802
6MP0009745_abnormal_behavioral_response3.11681114
7MP0002822_catalepsy2.90461364
8MP0005423_abnormal_somatic_nervous2.87984347
9MP0002064_seizures2.85274229
10MP0009046_muscle_twitch2.80566654
11MP0001968_abnormal_touch/_nociception2.70096983
12MP0002572_abnormal_emotion/affect_behav2.59749721
13MP0002734_abnormal_mechanical_nocicepti2.57682082
14MP0001486_abnormal_startle_reflex2.46145227
15MP0002272_abnormal_nervous_system2.32263271
16MP0009780_abnormal_chondrocyte_physiolo2.26525567
17MP0000778_abnormal_nervous_system2.14472382
18MP0002736_abnormal_nociception_after1.95746206
19MP0002733_abnormal_thermal_nociception1.94957915
20MP0004858_abnormal_nervous_system1.91606532
21MP0001440_abnormal_grooming_behavior1.89050752
22MP0002735_abnormal_chemical_nociception1.88714037
23MP0002184_abnormal_innervation1.85333067
24MP0001501_abnormal_sleep_pattern1.84450404
25MP0001970_abnormal_pain_threshold1.82356687
26MP0004811_abnormal_neuron_physiology1.81499951
27MP0002909_abnormal_adrenal_gland1.80759301
28MP0002067_abnormal_sensory_capabilities1.79464247
29MP0008877_abnormal_DNA_methylation1.78613961
30MP0000955_abnormal_spinal_cord1.70133762
31MP0002557_abnormal_social/conspecific_i1.70117185
32MP0006072_abnormal_retinal_apoptosis1.69205975
33MP0008569_lethality_at_weaning1.66909545
34MP0004924_abnormal_behavior1.66453743
35MP0005386_behavior/neurological_phenoty1.66453743
36MP0002638_abnormal_pupillary_reflex1.64693513
37MP0003329_amyloid_beta_deposits1.62525277
38MP0003879_abnormal_hair_cell1.60083865
39MP0002102_abnormal_ear_morphology1.58655953
40MP0004885_abnormal_endolymph1.56595905
41MP0000566_synostosis1.55393481
42MP0006292_abnormal_olfactory_placode1.52237217
43MP0003122_maternal_imprinting1.48118902
44MP0006276_abnormal_autonomic_nervous1.47671491
45MP0002882_abnormal_neuron_morphology1.46454902
46MP0003890_abnormal_embryonic-extraembry1.38613093
47MP0002066_abnormal_motor_capabilities/c1.38532368
48MP0003283_abnormal_digestive_organ1.36684402
49MP0003787_abnormal_imprinting1.36435793
50MP0004133_heterotaxia1.35719106
51MP0005248_abnormal_Harderian_gland1.32523526
52MP0005646_abnormal_pituitary_gland1.32271695
53MP0001984_abnormal_olfaction1.30611436
54MP0000751_myopathy1.30024988
55MP0003136_yellow_coat_color1.29869526
56MP0000013_abnormal_adipose_tissue1.27571365
57MP0005623_abnormal_meninges_morphology1.23429561
58MP0002152_abnormal_brain_morphology1.21576700
59MP0001529_abnormal_vocalization1.20808899
60MP0005645_abnormal_hypothalamus_physiol1.20450549
61MP0005253_abnormal_eye_physiology1.20432505
62MP0008789_abnormal_olfactory_epithelium1.19430707
63MP0003633_abnormal_nervous_system1.16002113
64MP0000569_abnormal_digit_pigmentation1.12154221
65MP0002938_white_spotting1.09628154
66MP0000049_abnormal_middle_ear1.09182600
67MP0002751_abnormal_autonomic_nervous1.07357511
68MP0004145_abnormal_muscle_electrophysio1.07131241
69MP0003937_abnormal_limbs/digits/tail_de1.05829969
70MP0003938_abnormal_ear_development1.04579704
71MP0001502_abnormal_circadian_rhythm1.04474113
72MP0004142_abnormal_muscle_tone1.03055696
73MP0000026_abnormal_inner_ear1.02425204
74MP0002233_abnormal_nose_morphology1.01381448
75MP0001299_abnormal_eye_distance/1.00926559
76MP0003631_nervous_system_phenotype0.99800645
77MP0001177_atelectasis0.95956940
78MP0003755_abnormal_palate_morphology0.95508006
79MP0004085_abnormal_heartbeat0.94943067
80MP0000631_abnormal_neuroendocrine_gland0.93418026
81MP0001905_abnormal_dopamine_level0.92821089
82MP0005367_renal/urinary_system_phenotyp0.91088065
83MP0000516_abnormal_urinary_system0.91088065
84MP0004742_abnormal_vestibular_system0.90746932
85MP0003634_abnormal_glial_cell0.89551376
86MP0001188_hyperpigmentation0.89338006
87MP0002069_abnormal_eating/drinking_beha0.87847089
88MP0002653_abnormal_ependyma_morphology0.87207632
89MP0004233_abnormal_muscle_weight0.86336361
90MP0008961_abnormal_basal_metabolism0.85824736
91MP0002229_neurodegeneration0.82918274
92MP0005187_abnormal_penis_morphology0.82693792
93MP0003137_abnormal_impulse_conducting0.82051140
94MP0002752_abnormal_somatic_nervous0.80867449
95MP0003861_abnormal_nervous_system0.80470997
96MP0005195_abnormal_posterior_eye0.79446566
97MP0000534_abnormal_ureter_morphology0.79320446
98MP0005499_abnormal_olfactory_system0.76936472
99MP0005394_taste/olfaction_phenotype0.76936472
100MP0003632_abnormal_nervous_system0.76275120
101MP0000647_abnormal_sebaceous_gland0.75540564
102MP0001485_abnormal_pinna_reflex0.75356970
103MP0001963_abnormal_hearing_physiology0.74711639
104MP0000579_abnormal_nail_morphology0.74487659
105MP0004215_abnormal_myocardial_fiber0.74248615
106MP0000920_abnormal_myelination0.74141862
107MP0002697_abnormal_eye_size0.73275418
108MP0003567_abnormal_fetal_cardiomyocyte0.73151971
109MP0003123_paternal_imprinting0.72406890
110MP0005551_abnormal_eye_electrophysiolog0.69252697
111MP0002837_dystrophic_cardiac_calcinosis0.68075076
112MP0008874_decreased_physiological_sensi0.65583014
113MP0002234_abnormal_pharynx_morphology0.64810114
114MP0001943_abnormal_respiration0.64477889
115MP0000537_abnormal_urethra_morphology0.62404157
116MP0008872_abnormal_physiological_respon0.61968418
117MP0003121_genomic_imprinting0.61526085
118MP0001348_abnormal_lacrimal_gland0.60544103
119MP0002090_abnormal_vision0.59289830
120MP0010769_abnormal_survival0.59279907
121MP0010386_abnormal_urinary_bladder0.58989289
122MP0003690_abnormal_glial_cell0.58899231
123MP0002082_postnatal_lethality0.57683910
124MP0010770_preweaning_lethality0.57683910
125MP0005535_abnormal_body_temperature0.56519018
126MP0010768_mortality/aging0.55254873
127MP0004484_altered_response_of0.54343157
128MP0003119_abnormal_digestive_system0.54084115

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.73483211
2Focal motor seizures (HP:0011153)6.13859460
3Focal seizures (HP:0007359)4.97138001
4Visual hallucinations (HP:0002367)4.39363280
5Epileptic encephalopathy (HP:0200134)4.14169370
6Atonic seizures (HP:0010819)3.66416968
7Progressive cerebellar ataxia (HP:0002073)3.63607564
8Febrile seizures (HP:0002373)3.58146799
9Action tremor (HP:0002345)3.54548057
10Ankle clonus (HP:0011448)3.53587122
11Absence seizures (HP:0002121)3.29008489
12Broad-based gait (HP:0002136)3.23688180
13Supranuclear gaze palsy (HP:0000605)3.23414981
14Generalized tonic-clonic seizures (HP:0002069)3.18276637
15Poor eye contact (HP:0000817)3.15087157
16Impaired vibration sensation in the lower limbs (HP:0002166)3.11277429
17Dialeptic seizures (HP:0011146)2.92953959
18Urinary bladder sphincter dysfunction (HP:0002839)2.90226987
19Depression (HP:0000716)2.89532854
20Abnormality of the labia minora (HP:0012880)2.86803897
21Impaired social interactions (HP:0000735)2.85984106
22Abnormal social behavior (HP:0012433)2.85984106
23Mutism (HP:0002300)2.85765493
24Torticollis (HP:0000473)2.81049416
25Gaze-evoked nystagmus (HP:0000640)2.76433119
26Dysdiadochokinesis (HP:0002075)2.75123425
27Termporal pattern (HP:0011008)2.71982217
28Insidious onset (HP:0003587)2.71982217
29Urinary urgency (HP:0000012)2.69146313
30Papilledema (HP:0001085)2.68010822
31Megalencephaly (HP:0001355)2.66319126
32Anxiety (HP:0000739)2.64969715
33Gait imbalance (HP:0002141)2.64472811
34Abnormality of the lower motor neuron (HP:0002366)2.61356162
35Genetic anticipation (HP:0003743)2.59726401
36Amblyopia (HP:0000646)2.58674692
37Truncal ataxia (HP:0002078)2.58330587
38Dysmetria (HP:0001310)2.56971141
39Abnormal eating behavior (HP:0100738)2.56534869
40Excessive salivation (HP:0003781)2.55825740
41Drooling (HP:0002307)2.55825740
42Hyperventilation (HP:0002883)2.55113678
43Intestinal atresia (HP:0011100)2.54629115
44Hepatoblastoma (HP:0002884)2.54080845
45Limb dystonia (HP:0002451)2.52498872
46Medial flaring of the eyebrow (HP:0010747)2.52175402
47Volvulus (HP:0002580)2.48735550
48Nephronophthisis (HP:0000090)2.48275417
49Focal dystonia (HP:0004373)2.46789553
50Postural instability (HP:0002172)2.45586620
51Spastic gait (HP:0002064)2.44650078
52Abnormality of the corticospinal tract (HP:0002492)2.42019995
53Hemiparesis (HP:0001269)2.40654728
54Abnormality of midbrain morphology (HP:0002418)2.37574368
55Molar tooth sign on MRI (HP:0002419)2.37574368
56Genital tract atresia (HP:0001827)2.37555231
57Pancreatic fibrosis (HP:0100732)2.32467355
58True hermaphroditism (HP:0010459)2.30079331
59Stereotypic behavior (HP:0000733)2.28460315
60Progressive inability to walk (HP:0002505)2.27417214
61Craniofacial dystonia (HP:0012179)2.27248316
62Lissencephaly (HP:0001339)2.26730308
63Epileptiform EEG discharges (HP:0011182)2.25718569
64Congenital primary aphakia (HP:0007707)2.23374868
65EEG with generalized epileptiform discharges (HP:0011198)2.22236257
66Vaginal atresia (HP:0000148)2.21938770
67Pheochromocytoma (HP:0002666)2.21897893
68Pointed chin (HP:0000307)2.21093827
69Annular pancreas (HP:0001734)2.20539510
70Impaired smooth pursuit (HP:0007772)2.20374702
71Amyotrophic lateral sclerosis (HP:0007354)2.18447268
72Hemiplegia (HP:0002301)2.17017845
73Cerebral inclusion bodies (HP:0100314)2.16822883
74Hypsarrhythmia (HP:0002521)2.16380477
75Ventricular fibrillation (HP:0001663)2.16102785
76Oligodactyly (hands) (HP:0001180)2.15825892
77Scanning speech (HP:0002168)2.15498559
78Intention tremor (HP:0002080)2.13917550
79Pachygyria (HP:0001302)2.13021967
80Lower limb muscle weakness (HP:0007340)2.12928734
81Optic nerve hypoplasia (HP:0000609)2.10747037
82Insomnia (HP:0100785)2.10543866
83Fetal akinesia sequence (HP:0001989)2.10027815
84Neurofibrillary tangles (HP:0002185)2.08642838
85Pancreatic cysts (HP:0001737)2.08018399
86Obstructive sleep apnea (HP:0002870)2.06668827
87Agitation (HP:0000713)2.06080256
88Bradykinesia (HP:0002067)2.03983437
89Nephrogenic diabetes insipidus (HP:0009806)2.03660233
90Exotropia (HP:0000577)2.02811366
91Renal hypoplasia (HP:0000089)2.00230794
92Abnormality of the renal medulla (HP:0100957)1.99431321
93Absent speech (HP:0001344)1.98608746
94Lower limb amyotrophy (HP:0007210)1.97574930
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.97367986
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97367986
97Protruding tongue (HP:0010808)1.97322633
98Hypothermia (HP:0002045)1.96361896
99Cortical dysplasia (HP:0002539)1.96331418
100Retinal dysplasia (HP:0007973)1.95472143
101Dysmetric saccades (HP:0000641)1.95404700
102Gastrointestinal atresia (HP:0002589)1.93591711
103Specific learning disability (HP:0001328)1.92980052
104Septo-optic dysplasia (HP:0100842)1.92608643
105Impaired vibratory sensation (HP:0002495)1.91824421
106Abnormality of ocular smooth pursuit (HP:0000617)1.91141904
107Resting tremor (HP:0002322)1.90913507
108Colon cancer (HP:0003003)1.90310159
109Polyphagia (HP:0002591)1.89166245
110Lower limb asymmetry (HP:0100559)1.89026177
111Poor suck (HP:0002033)1.88172038
112Hypoventilation (HP:0002791)1.87742262
113Clonus (HP:0002169)1.87306769
114Chronic hepatic failure (HP:0100626)1.87228670
115Aplasia involving bones of the upper limbs (HP:0009823)1.87192536
116Aplasia of the phalanges of the hand (HP:0009802)1.87192536
117Aplasia involving bones of the extremities (HP:0009825)1.87192536
118Postaxial hand polydactyly (HP:0001162)1.85718006
119Bundle branch block (HP:0011710)1.85329530
120Ankyloglossia (HP:0010296)1.84652930
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.83086078
122Type II lissencephaly (HP:0007260)1.82600374
123Neuroendocrine neoplasm (HP:0100634)1.82316489
124Inability to walk (HP:0002540)1.81372923
125Diplopia (HP:0000651)1.81316517
126Abnormality of binocular vision (HP:0011514)1.81316517
127Abnormal EKG (HP:0003115)1.77928276
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77755961
129Incomplete penetrance (HP:0003829)1.76612158
130Prolonged QT interval (HP:0001657)1.75487567
131Esotropia (HP:0000565)1.73418894
132Split foot (HP:0001839)1.73274321
133Inappropriate behavior (HP:0000719)1.73074296
134Neoplasm of the peripheral nervous system (HP:0100007)1.72809828
135Cutaneous finger syndactyly (HP:0010554)1.72233037
136Spastic tetraplegia (HP:0002510)1.69762907
137Status epilepticus (HP:0002133)1.69444448
138Anophthalmia (HP:0000528)1.68734886
139Failure to thrive in infancy (HP:0001531)1.68540489
140Akinesia (HP:0002304)1.68079159
141Generalized myoclonic seizures (HP:0002123)1.67563339
142Hypoplasia of the brainstem (HP:0002365)1.67460883
143Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67460883
144Narrow forehead (HP:0000341)1.67336938
145Aqueductal stenosis (HP:0002410)1.67053403
146Pendular nystagmus (HP:0012043)1.66819731
147Labial hypoplasia (HP:0000066)1.66808839
148Sleep apnea (HP:0010535)1.64861556
149Poor coordination (HP:0002370)1.64024824
150Abnormality of the astrocytes (HP:0100707)1.63260531
151Astrocytoma (HP:0009592)1.63260531
152Oligodactyly (HP:0012165)1.60280488
153Methylmalonic acidemia (HP:0002912)1.58813571
154Scrotal hypoplasia (HP:0000046)1.57701896
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.57228620
156Morphological abnormality of the pyramidal tract (HP:0002062)1.56818185
157Shawl scrotum (HP:0000049)1.54180354
158Double outlet right ventricle (HP:0001719)1.53883834
159Congenital malformation of the right heart (HP:0011723)1.53883834
160Anencephaly (HP:0002323)1.53539463
161Abnormality of salivation (HP:0100755)1.53365299
162Neoplasm of the oral cavity (HP:0100649)1.52496757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.09901914
2EPHA44.09493449
3NTRK34.04560135
4MAP3K93.92965159
5MAP3K42.77602027
6FRK2.76940320
7DAPK22.68325952
8MINK12.58941794
9PAK62.43244760
10PRKD32.19778236
11KSR22.19290865
12NTRK22.12963119
13MAP2K72.07579403
14CAMKK11.91819169
15NTRK11.88124336
16KSR11.87036243
17MKNK21.80635916
18CASK1.66422846
19MAP2K41.58224513
20LATS21.56725432
21CDK51.56448100
22TRIM281.48932582
23MAPK131.46857269
24TYRO31.38492574
25PHKG11.37171988
26PHKG21.37171988
27DAPK11.34331130
28TNIK1.32601213
29CSNK1G11.32423408
30PLK21.31840317
31SIK21.31320580
32MAP4K21.26701017
33MAP3K21.26202276
34UHMK11.25730986
35CDK191.25190464
36BMPR1B1.22510435
37GRK51.21777981
38MAP3K121.17044992
39STK381.16803656
40PNCK1.16361150
41CAMKK21.15695804
42PRPF4B1.13272219
43ARAF1.09952198
44MKNK11.09099377
45PRKCG1.09096618
46SRPK11.08670864
47CDK181.01929382
48CDK151.00883798
49PAK31.00635332
50CDK140.99750705
51WEE10.99152361
52CSNK1A1L0.99052426
53CSNK1G20.92806765
54RET0.90374937
55ALK0.89806714
56CDK11A0.87996941
57CDK30.86956245
58RIPK40.85410255
59CAMK2A0.85159027
60SGK4940.84848993
61SGK2230.84848993
62LMTK20.83352029
63ADRBK20.82410779
64EPHA30.82250119
65ZAK0.81437835
66MARK20.79922907
67DDR20.79697235
68PKN10.78796289
69PRKCH0.78743897
70FES0.77495204
71CAMK10.74975881
72DYRK30.74921490
73LATS10.72146669
74PLK40.70823896
75ERBB30.70575702
76* STK110.69514790
77CAMK2B0.69091409
78RAF10.68824821
79OXSR10.68654796
80PLK30.68180480
81YES10.67382527
82DYRK1A0.66895461
83STK38L0.66607202
84CDC70.65075010
85VRK10.64755017
86CDC42BPA0.63539877
87LIMK10.63096393
88CAMK1G0.62657906
89PDGFRA0.62469890
90RIPK10.61263499
91MAP3K130.61239636
92INSRR0.60390776
93SGK20.60134377
94WNK10.59730827
95PDPK10.59084303
96PRKCZ0.57583963
97PTK2B0.56991861
98NEK10.56643956
99SGK30.56131269
100GRK10.55831972
101PINK10.55637012
102EPHB20.53111814
103TSSK60.52653088
104* SGK10.51536096
105DAPK30.51360749
106PDK10.51133621
107CSNK1E0.50929636
108FER0.50835494
109CSNK1D0.49604553
110CSNK1A10.48855234
111DMPK0.48780541
112FGFR20.48435737
113SCYL20.48184361
114* RPS6KA30.47461460
115BCR0.46868254
116MAPK100.45879015
117WNK30.45784738
118PRKCE0.45353332
119FYN0.43676439
120CAMK40.43220119
121NME10.42723020
122MAPK150.42640695
123CSNK1G30.42566348
124MAP3K10.42486066
125NEK60.41838086
126WNK40.41775370
127TAF10.41042532
128PRKACA0.40333675
129NUAK10.39913507
130CCNB10.39719952
131ICK0.39669524
132MAP2K10.39582025
133CAMK2D0.39326478
134STK390.38856297
135PLK10.38785010
136RPS6KA20.38660659
137PRKACB0.38275198
138DYRK20.38196841
139OBSCN0.36180408
140ATM0.35092893
141BRSK20.35071140
142ROCK10.33439558
143PRKAA10.33342718

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.14958329
2Synaptic vesicle cycle_Homo sapiens_hsa047213.13406905
3Olfactory transduction_Homo sapiens_hsa047402.76733061
4Circadian entrainment_Homo sapiens_hsa047132.57540490
5GABAergic synapse_Homo sapiens_hsa047272.53431687
6Long-term potentiation_Homo sapiens_hsa047202.48122578
7Glutamatergic synapse_Homo sapiens_hsa047242.41996184
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38152929
9Morphine addiction_Homo sapiens_hsa050322.36921675
10Amphetamine addiction_Homo sapiens_hsa050312.34777301
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33679302
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22969000
13Dopaminergic synapse_Homo sapiens_hsa047282.20583223
14Salivary secretion_Homo sapiens_hsa049701.99420669
15Cholinergic synapse_Homo sapiens_hsa047251.95314209
16Insulin secretion_Homo sapiens_hsa049111.94273690
17Cocaine addiction_Homo sapiens_hsa050301.80301241
18Protein export_Homo sapiens_hsa030601.79999556
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.78672838
20Gastric acid secretion_Homo sapiens_hsa049711.78455200
21Butanoate metabolism_Homo sapiens_hsa006501.77380490
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77353824
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77124706
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69610109
25Oxytocin signaling pathway_Homo sapiens_hsa049211.66656050
26Renin secretion_Homo sapiens_hsa049241.64922374
27Long-term depression_Homo sapiens_hsa047301.62534719
28Taste transduction_Homo sapiens_hsa047421.62166276
29Gap junction_Homo sapiens_hsa045401.55447807
30Serotonergic synapse_Homo sapiens_hsa047261.53913265
31Oxidative phosphorylation_Homo sapiens_hsa001901.49886934
32Axon guidance_Homo sapiens_hsa043601.48643987
33GnRH signaling pathway_Homo sapiens_hsa049121.45002588
34Calcium signaling pathway_Homo sapiens_hsa040201.41919213
35Steroid biosynthesis_Homo sapiens_hsa001001.41026421
36Glioma_Homo sapiens_hsa052141.30942179
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30844629
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28455735
39Parkinsons disease_Homo sapiens_hsa050121.26509820
40Estrogen signaling pathway_Homo sapiens_hsa049151.25756496
41Type II diabetes mellitus_Homo sapiens_hsa049301.25715613
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24281893
43cAMP signaling pathway_Homo sapiens_hsa040241.24035600
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21173119
45ErbB signaling pathway_Homo sapiens_hsa040121.18482268
46Melanogenesis_Homo sapiens_hsa049161.16434095
47Basal transcription factors_Homo sapiens_hsa030221.12537382
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07357995
49Collecting duct acid secretion_Homo sapiens_hsa049661.06143573
50Huntingtons disease_Homo sapiens_hsa050161.02494250
51Oocyte meiosis_Homo sapiens_hsa041141.01070922
52Propanoate metabolism_Homo sapiens_hsa006401.01041837
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97935990
54Dilated cardiomyopathy_Homo sapiens_hsa054140.97579091
55Dorso-ventral axis formation_Homo sapiens_hsa043200.96923374
56Cardiac muscle contraction_Homo sapiens_hsa042600.96170546
57Alzheimers disease_Homo sapiens_hsa050100.96152760
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.95851682
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91791344
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91683744
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.90520273
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88400693
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87924201
64Nitrogen metabolism_Homo sapiens_hsa009100.84290422
65Vibrio cholerae infection_Homo sapiens_hsa051100.83316917
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83044377
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81262848
68Regulation of autophagy_Homo sapiens_hsa041400.79535433
69Basal cell carcinoma_Homo sapiens_hsa052170.77539469
70MAPK signaling pathway_Homo sapiens_hsa040100.77321458
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76161889
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.75785488
73Endometrial cancer_Homo sapiens_hsa052130.75723322
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75677733
75Choline metabolism in cancer_Homo sapiens_hsa052310.74754742
76Folate biosynthesis_Homo sapiens_hsa007900.74504802
77Thyroid hormone synthesis_Homo sapiens_hsa049180.74364442
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74048333
79Selenocompound metabolism_Homo sapiens_hsa004500.73237324
80Renal cell carcinoma_Homo sapiens_hsa052110.72567861
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71449842
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71165755
83Fanconi anemia pathway_Homo sapiens_hsa034600.69784203
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69704992
85Pancreatic secretion_Homo sapiens_hsa049720.69229643
86VEGF signaling pathway_Homo sapiens_hsa043700.68792000
87mTOR signaling pathway_Homo sapiens_hsa041500.68345879
88Non-homologous end-joining_Homo sapiens_hsa034500.67939768
89Phototransduction_Homo sapiens_hsa047440.67853992
90Ras signaling pathway_Homo sapiens_hsa040140.67409804
91Rap1 signaling pathway_Homo sapiens_hsa040150.67260035
92RNA polymerase_Homo sapiens_hsa030200.66037184
93Vitamin B6 metabolism_Homo sapiens_hsa007500.65963329
94Wnt signaling pathway_Homo sapiens_hsa043100.65133028
95Alcoholism_Homo sapiens_hsa050340.64872132
96Ether lipid metabolism_Homo sapiens_hsa005650.62155042
97beta-Alanine metabolism_Homo sapiens_hsa004100.60581421
98Glucagon signaling pathway_Homo sapiens_hsa049220.60455693
99Endocytosis_Homo sapiens_hsa041440.59817817
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.59104465
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59083170
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58888378
103Non-small cell lung cancer_Homo sapiens_hsa052230.58599843
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58401810
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56640452
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56536901
107Insulin signaling pathway_Homo sapiens_hsa049100.56311484
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56120875
109Hedgehog signaling pathway_Homo sapiens_hsa043400.55553959
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55534999
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54918050
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53594540
113Prion diseases_Homo sapiens_hsa050200.51789775
114RNA degradation_Homo sapiens_hsa030180.51181178
115Colorectal cancer_Homo sapiens_hsa052100.50189831
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50029000
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49503820
118Hippo signaling pathway_Homo sapiens_hsa043900.49211546
119Tight junction_Homo sapiens_hsa045300.47379025
120Linoleic acid metabolism_Homo sapiens_hsa005910.46914557
121TGF-beta signaling pathway_Homo sapiens_hsa043500.45979058
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45772887
123Mismatch repair_Homo sapiens_hsa034300.44436307
124Ovarian steroidogenesis_Homo sapiens_hsa049130.42891666
125Fatty acid metabolism_Homo sapiens_hsa012120.42102137
126Circadian rhythm_Homo sapiens_hsa047100.40257768
127mRNA surveillance pathway_Homo sapiens_hsa030150.40208148
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39928652
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39172642
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.38924780
131Tryptophan metabolism_Homo sapiens_hsa003800.38238518
132Peroxisome_Homo sapiens_hsa041460.37940158
133Bile secretion_Homo sapiens_hsa049760.37536087
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36799211
135Melanoma_Homo sapiens_hsa052180.35855120
136Inositol phosphate metabolism_Homo sapiens_hsa005620.34260352
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34115850
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33902606
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33372137
140Type I diabetes mellitus_Homo sapiens_hsa049400.31549633

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