ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	6.59346608
2	regulation of action potential (GO:0098900)	5.82987804
3	regulation of cell communication by electrical coupling (GO:0010649)	5.09139587
4	neural tube formation (GO:0001841)	4.97670786
5	negative regulation of sodium ion transport (GO:0010766)	4.95165946
6	regulation of relaxation of muscle (GO:1901077)	4.95080559
7	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.77635023
8	platelet dense granule organization (GO:0060155)	4.64797474
9	negative regulation of protein localization to cell surface (GO:2000009)	4.61987929
10	positive regulation of action potential (GO:0045760)	4.29692472
11	aggressive behavior (GO:0002118)	4.16458838
12	acrosome reaction (GO:0007340)	3.87993334
13	relaxation of cardiac muscle (GO:0055119)	3.86531382
14	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.80585471
15	negative regulation of heart rate (GO:0010459)	3.78509716
16	reflex (GO:0060004)	3.77098790
17	regulation of uterine smooth muscle contraction (GO:0070472)	3.69113263
18	phospholipid homeostasis (GO:0055091)	3.68874187
19	keratinocyte development (GO:0003334)	3.64750813
20	protein neddylation (GO:0045116)	3.57810360
21	behavioral response to nicotine (GO:0035095)	3.52091932
22	neuronal action potential propagation (GO:0019227)	3.50945329
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.50856676
24	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.38953719
25	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.37802311
26	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.36942042
27	intraciliary transport (GO:0042073)	3.29887877
28	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.28295622
29	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.28295622
30	regulation of glutamate secretion (GO:0014048)	3.21823639
31	positive regulation of vascular permeability (GO:0043117)	3.20937781
32	cellular ketone body metabolic process (GO:0046950)	3.19863693
33	axoneme assembly (GO:0035082)	3.17227037
34	regulation of neurotransmitter uptake (GO:0051580)	3.16127111
35	urinary tract smooth muscle contraction (GO:0014848)	3.14161721
36	protein localization to cilium (GO:0061512)	3.14129823
37	response to pheromone (GO:0019236)	3.09209664
38	righting reflex (GO:0060013)	3.01390937
39	negative regulation of cAMP-mediated signaling (GO:0043951)	2.95998210
40	reverse cholesterol transport (GO:0043691)	2.95889690
41	positive regulation of muscle hypertrophy (GO:0014742)	2.95098162
42	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.95098162
43	photoreceptor cell maintenance (GO:0045494)	2.92804699
44	retinal ganglion cell axon guidance (GO:0031290)	2.88854059
45	microtubule severing (GO:0051013)	2.84334735
46	adult feeding behavior (GO:0008343)	2.83689696
47	regulation of hippo signaling (GO:0035330)	2.82219539
48	embryonic epithelial tube formation (GO:0001838)	2.79373355
49	cornea development in camera-type eye (GO:0061303)	2.77880071
50	ketone body metabolic process (GO:1902224)	2.77859987
51	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.77682348
52	hindbrain development (GO:0030902)	2.77638883
53	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75082044
54	neuronal action potential (GO:0019228)	2.74464644
55	tryptophan catabolic process (GO:0006569)	2.73866225
56	indole-containing compound catabolic process (GO:0042436)	2.73866225
57	indolalkylamine catabolic process (GO:0046218)	2.73866225
58	DNA deamination (GO:0045006)	2.73584085
59	dopamine transport (GO:0015872)	2.71819196
60	renal tubule morphogenesis (GO:0061333)	2.71474689
61	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.70951415
62	methionine biosynthetic process (GO:0009086)	2.70791825
63	signal peptide processing (GO:0006465)	2.70776377
64	protein polyglutamylation (GO:0018095)	2.69916085
65	transmission of nerve impulse (GO:0019226)	2.68327600
66	regulation of sodium ion transmembrane transporter activity (GO:2000649)	2.65050646
67	cilium morphogenesis (GO:0060271)	2.64407815
68	negative regulation of cation channel activity (GO:2001258)	2.63516593
69	sleep (GO:0030431)	2.60709129
70	regulation of timing of cell differentiation (GO:0048505)	2.60523911
71	L-methionine salvage (GO:0071267)	2.60293346
72	L-methionine biosynthetic process (GO:0071265)	2.60293346
73	amino acid salvage (GO:0043102)	2.60293346
74	indole-containing compound metabolic process (GO:0042430)	2.59403724
75	indolalkylamine metabolic process (GO:0006586)	2.59249332
76	epithelial tube formation (GO:0072175)	2.58791004
77	anterograde synaptic vesicle transport (GO:0048490)	2.56032816
78	adaptation of signaling pathway (GO:0023058)	2.54363064
79	regulation of female receptivity (GO:0045924)	2.53798483
80	histone H2A acetylation (GO:0043968)	2.53552246
81	detection of light stimulus involved in visual perception (GO:0050908)	2.52991038
82	detection of light stimulus involved in sensory perception (GO:0050962)	2.52991038
83	nephron epithelium morphogenesis (GO:0072088)	2.52313167
84	nephron tubule morphogenesis (GO:0072078)	2.52313167
85	negative chemotaxis (GO:0050919)	2.51666857
86	cellular response to sterol (GO:0036315)	2.50616852
87	regulation of cilium movement (GO:0003352)	2.48653215
88	cellular response to cholesterol (GO:0071397)	2.48252919
89	regulation of membrane depolarization (GO:0003254)	2.47533357
90	positive regulation of digestive system process (GO:0060456)	2.47104995
91	multicellular organism reproduction (GO:0032504)	2.45923242
92	adenosine metabolic process (GO:0046085)	2.45339456
93	relaxation of muscle (GO:0090075)	2.45314649
94	negative regulation of response to food (GO:0032096)	2.44885854
95	negative regulation of appetite (GO:0032099)	2.44885854
96	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.40287027
97	amine catabolic process (GO:0009310)	2.40008239
98	cellular biogenic amine catabolic process (GO:0042402)	2.40008239
99	regulation of heart rate by cardiac conduction (GO:0086091)	2.39354979
100	regulation of development, heterochronic (GO:0040034)	2.39265340

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.49481551
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.34181419
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.91106846
4	GATA1_22025678_ChIP-Seq_K562_Human	2.90048803
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.85786605
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77730997
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75350546
8	VDR_22108803_ChIP-Seq_LS180_Human	2.62911023
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.54496120
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.53938827
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.41953360
12	P300_19829295_ChIP-Seq_ESCs_Human	2.11527245
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.11229637
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09061598
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.07691928
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.94199578
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93377989
18	FUS_26573619_Chip-Seq_HEK293_Human	1.88925395
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.83642154
20	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.82379758
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.82103719
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.73152069
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73089103
24	AR_25329375_ChIP-Seq_VCAP_Human	1.72854098
25	STAT3_23295773_ChIP-Seq_U87_Human	1.72378156
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.70553993
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66726756
28	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.66444910
29	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63577927
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.62738152
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62709252
32	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.62688367
33	HTT_18923047_ChIP-ChIP_STHdh_Human	1.60423953
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59995226
35	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.58288519
36	EWS_26573619_Chip-Seq_HEK293_Human	1.56698518
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.55666349
38	TCF4_22108803_ChIP-Seq_LS180_Human	1.55120981
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.53693120
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50127295
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44831525
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43751663
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40951781
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40951781
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40687309
46	TCF4_23295773_ChIP-Seq_U87_Human	1.40460512
47	RUNX2_22187159_ChIP-Seq_PCA_Human	1.39460600
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.37584449
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.36824509
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36722402
51	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.36402103
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35204536
53	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.34724877
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32782697
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29429532
56	CDX2_22108803_ChIP-Seq_LS180_Human	1.27533049
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27419382
58	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.27412823
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25968620
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.25819390
61	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25295885
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25156510
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.25156510
64	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.23137945
65	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22222570
66	P53_22387025_ChIP-Seq_ESCs_Mouse	1.22028235
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.21416402
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20510311
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18995887
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18995887
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17516150
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17049449
73	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.16705103
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16207865
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16207865
76	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.14249678
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13616818
78	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.11760608
79	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11290824
80	AR_21572438_ChIP-Seq_LNCaP_Human	1.10671114
81	KDM2B_26808549_Chip-Seq_REH_Human	1.10348406
82	P300_18555785_Chip-Seq_ESCs_Mouse	1.09898785
83	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09461806
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08330053
85	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05891384
86	JUN_21703547_ChIP-Seq_K562_Human	1.04578971
87	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04377919
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03152230
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02923024
90	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00416792
91	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.98393748
92	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.98393748
93	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97495513
94	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97414787
95	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96368064
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95478487
97	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.95267887
98	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.95024362
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.94422276
100	RXR_22108803_ChIP-Seq_LS180_Human	0.94136642

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	4.31829054
2	MP0002254_reproductive_system_inflammat	3.58732088
3	MP0001968_abnormal_touch/_nociception	3.13583548
4	MP0003195_calcinosis	2.89285946
5	MP0005645_abnormal_hypothalamus_physiol	2.84938593
6	MP0008877_abnormal_DNA_methylation	2.82610472
7	MP0008872_abnormal_physiological_respon	2.50070591
8	MP0002735_abnormal_chemical_nociception	2.50024580
9	MP0004147_increased_porphyrin_level	2.33731719
10	MP0005464_abnormal_platelet_physiology	2.26672394
11	MP0008004_abnormal_stomach_pH	2.15333113
12	MP0000516_abnormal_urinary_system	2.09497077
13	MP0005367_renal/urinary_system_phenotyp	2.09497077
14	MP0000372_irregular_coat_pigmentation	2.09069770
15	MP0005551_abnormal_eye_electrophysiolog	2.07128711
16	MP0003136_yellow_coat_color	2.06671265
17	MP0004215_abnormal_myocardial_fiber	2.03804047
18	MP0002102_abnormal_ear_morphology	1.90581277
19	MP0010386_abnormal_urinary_bladder	1.87919930
20	MP0008995_early_reproductive_senescence	1.82702541
21	MP0000569_abnormal_digit_pigmentation	1.78416869
22	MP0006054_spinal_hemorrhage	1.77164922
23	MP0001666_abnormal_nutrient_absorption	1.66925908
24	MP0002837_dystrophic_cardiac_calcinosis	1.62916321
25	MP0004484_altered_response_of	1.58715825
26	MP0006072_abnormal_retinal_apoptosis	1.58134466
27	MP0009046_muscle_twitch	1.57451542
28	MP0004019_abnormal_vitamin_homeostasis	1.56448860
29	MP0002822_catalepsy	1.53149030
30	MP0005167_abnormal_blood-brain_barrier	1.49974131
31	MP0003880_abnormal_central_pattern	1.48505665
32	MP0008775_abnormal_heart_ventricle	1.46625788
33	MP0005253_abnormal_eye_physiology	1.46390282
34	MP0006276_abnormal_autonomic_nervous	1.42468556
35	MP0009780_abnormal_chondrocyte_physiolo	1.42230769
36	MP0001756_abnormal_urination	1.38931262
37	MP0001970_abnormal_pain_threshold	1.37137925
38	MP0002234_abnormal_pharynx_morphology	1.35461263
39	MP0000383_abnormal_hair_follicle	1.34820691
40	MP0009745_abnormal_behavioral_response	1.32629383
41	MP0003787_abnormal_imprinting	1.31945939
42	MP0005646_abnormal_pituitary_gland	1.31366973
43	MP0001765_abnormal_ion_homeostasis	1.31148077
44	MP0002938_white_spotting	1.30919939
45	MP0005084_abnormal_gallbladder_morpholo	1.27844283
46	MP0003718_maternal_effect	1.27523839
47	MP0001529_abnormal_vocalization	1.24311075
48	MP0005636_abnormal_mineral_homeostasis	1.20847634
49	MP0004133_heterotaxia	1.20504238
50	MP0005220_abnormal_exocrine_pancreas	1.18828562
51	MP0000631_abnormal_neuroendocrine_gland	1.18717773
52	MP0002734_abnormal_mechanical_nocicepti	1.17661689
53	MP0010329_abnormal_lipoprotein_level	1.13579818
54	MP0001485_abnormal_pinna_reflex	1.12818164
55	MP0001501_abnormal_sleep_pattern	1.11463103
56	MP0006292_abnormal_olfactory_placode	1.11144966
57	MP0002572_abnormal_emotion/affect_behav	1.10962408
58	MP0008875_abnormal_xenobiotic_pharmacok	1.10603570
59	MP0002653_abnormal_ependyma_morphology	1.10279865
60	MP0005410_abnormal_fertilization	1.09930451
61	MP0002272_abnormal_nervous_system	1.09236223
62	MP0004084_abnormal_cardiac_muscle	1.09108021
63	MP0001486_abnormal_startle_reflex	1.07842029
64	MP0002733_abnormal_thermal_nociception	1.06944618
65	MP0002168_other_aberrant_phenotype	1.05539439
66	MP0003122_maternal_imprinting	1.03438472
67	MP0005395_other_phenotype	1.01678145
68	MP0000465_gastrointestinal_hemorrhage	1.01118099
69	MP0002638_abnormal_pupillary_reflex	1.01006095
70	MP0002138_abnormal_hepatobiliary_system	1.00975368
71	MP0000230_abnormal_systemic_arterial	0.96627451
72	MP0001986_abnormal_taste_sensitivity	0.95087074
73	MP0003252_abnormal_bile_duct	0.93962716
74	MP0002067_abnormal_sensory_capabilities	0.93500112
75	MP0004043_abnormal_pH_regulation	0.92840165
76	MP0002064_seizures	0.92578923
77	MP0004085_abnormal_heartbeat	0.92529833
78	MP0003646_muscle_fatigue	0.89802855
79	MP0002909_abnormal_adrenal_gland	0.88171163
80	MP0003698_abnormal_male_reproductive	0.86004474
81	MP0000538_abnormal_urinary_bladder	0.85702558
82	MP0003119_abnormal_digestive_system	0.84373325
83	MP0001440_abnormal_grooming_behavior	0.82741810
84	MP0002557_abnormal_social/conspecific_i	0.82117652
85	MP0003943_abnormal_hepatobiliary_system	0.81695129
86	MP0004924_abnormal_behavior	0.81625099
87	MP0005386_behavior/neurological_phenoty	0.81625099
88	MP0003638_abnormal_response/metabolism_	0.81366202
89	MP0002928_abnormal_bile_duct	0.81251096
90	MP0005174_abnormal_tail_pigmentation	0.79544705
91	MP0001984_abnormal_olfaction	0.79503935
92	MP0000427_abnormal_hair_cycle	0.77059883
93	MP0002693_abnormal_pancreas_physiology	0.76804380
94	MP0010678_abnormal_skin_adnexa	0.75873902
95	MP0002160_abnormal_reproductive_system	0.73810390
96	MP0005647_abnormal_sex_gland	0.72579944
97	MP0005195_abnormal_posterior_eye	0.72221345
98	MP0003183_abnormal_peptide_metabolism	0.71549698
99	MP0002063_abnormal_learning/memory/cond	0.70788837
100	MP0003635_abnormal_synaptic_transmissio	0.70413196

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	5.58873732
2	Proximal tubulopathy (HP:0000114)	4.32456447
3	Pancreatic cysts (HP:0001737)	3.53173798
4	True hermaphroditism (HP:0010459)	3.48146709
5	Congenital stationary night blindness (HP:0007642)	3.36572134
6	Pancreatic fibrosis (HP:0100732)	3.20897504
7	Absent eyebrow (HP:0002223)	3.14708118
8	Generalized aminoaciduria (HP:0002909)	2.96695337
9	Prolonged bleeding time (HP:0003010)	2.88414235
10	Medial flaring of the eyebrow (HP:0010747)	2.84325283
11	Genetic anticipation (HP:0003743)	2.83786042
12	Hyperlipoproteinemia (HP:0010980)	2.79630180
13	Attenuation of retinal blood vessels (HP:0007843)	2.78215074
14	Abnormality of midbrain morphology (HP:0002418)	2.77652409
15	Molar tooth sign on MRI (HP:0002419)	2.77652409
16	Progressive cerebellar ataxia (HP:0002073)	2.76199355
17	Abolished electroretinogram (ERG) (HP:0000550)	2.74532460
18	Decreased central vision (HP:0007663)	2.65677651
19	Dyschromatopsia (HP:0007641)	2.60203392
20	Gait imbalance (HP:0002141)	2.59738425
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.59590557
22	Increased mean platelet volume (HP:0011877)	2.54248346
23	Decreased circulating renin level (HP:0003351)	2.53257752
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.48392027
25	Renal cortical cysts (HP:0000803)	2.48189412
26	Nephronophthisis (HP:0000090)	2.46731022
27	Volvulus (HP:0002580)	2.44769607
28	Gaze-evoked nystagmus (HP:0000640)	2.43887519
29	Parakeratosis (HP:0001036)	2.43430638
30	Petechiae (HP:0000967)	2.42726548
31	Congenital primary aphakia (HP:0007707)	2.38939650
32	Gastrointestinal atresia (HP:0002589)	2.37427019
33	Fair hair (HP:0002286)	2.36453567
34	Hypothermia (HP:0002045)	2.32778938
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.32208105
36	Type I transferrin isoform profile (HP:0003642)	2.30954552
37	Menorrhagia (HP:0000132)	2.30925759
38	Genital tract atresia (HP:0001827)	2.30522257
39	Abnormal platelet volume (HP:0011876)	2.27764253
40	Vaginal atresia (HP:0000148)	2.26544113
41	Cystic liver disease (HP:0006706)	2.19318094
42	Abnormality of methionine metabolism (HP:0010901)	2.19286924
43	Hemiparesis (HP:0001269)	2.17605878
44	Abnormality of the renal medulla (HP:0100957)	2.13435357
45	Unilateral renal agenesis (HP:0000122)	2.13226473
46	Absent eyelashes (HP:0000561)	2.11771372
47	Hypoplasia of the fovea (HP:0007750)	2.11738856
48	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.11738856
49	Male pseudohermaphroditism (HP:0000037)	2.11307378
50	Postaxial foot polydactyly (HP:0001830)	2.10531315
51	Hyperaldosteronism (HP:0000859)	2.08910286
52	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.08622649
53	Abnormality of the renal cortex (HP:0011035)	2.06329978
54	Hyperventilation (HP:0002883)	2.05960573
55	Small hand (HP:0200055)	2.05883482
56	Pigmentary retinal degeneration (HP:0001146)	2.05755013
57	Severe visual impairment (HP:0001141)	2.05694744
58	Ectropion (HP:0000656)	2.04717983
59	Hyperglycinuria (HP:0003108)	2.04046520
60	Furrowed tongue (HP:0000221)	2.02041138
61	Anophthalmia (HP:0000528)	2.01823078
62	Facial diplegia (HP:0001349)	2.00779782
63	Follicular hyperkeratosis (HP:0007502)	2.00772323
64	Febrile seizures (HP:0002373)	2.00630437
65	Nephrogenic diabetes insipidus (HP:0009806)	1.99635793
66	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.98811594
67	Alopecia of scalp (HP:0002293)	1.97568345
68	Short tibia (HP:0005736)	1.96994724
69	Postaxial hand polydactyly (HP:0001162)	1.94290100
70	Increased density of long bones (HP:0006392)	1.93667615
71	Reduced antithrombin III activity (HP:0001976)	1.90946904
72	Abnormal protein glycosylation (HP:0012346)	1.90166139
73	Abnormal glycosylation (HP:0012345)	1.90166139
74	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.90166139
75	Abnormal protein N-linked glycosylation (HP:0012347)	1.90166139
76	Constricted visual fields (HP:0001133)	1.90110585
77	Hypomagnesemia (HP:0002917)	1.89018366
78	Focal seizures (HP:0007359)	1.88863252
79	Pendular nystagmus (HP:0012043)	1.88381131
80	Absent hair (HP:0002298)	1.88362186
81	Renal hypoplasia (HP:0000089)	1.87815872
82	Renal Fanconi syndrome (HP:0001994)	1.86360200
83	Anencephaly (HP:0002323)	1.86013174
84	Increased corneal curvature (HP:0100692)	1.85803921
85	Keratoconus (HP:0000563)	1.85803921
86	Abnormality of urine glucose concentration (HP:0011016)	1.85485664
87	Glycosuria (HP:0003076)	1.85485664
88	Hyperglycinemia (HP:0002154)	1.84915940
89	Acanthocytosis (HP:0001927)	1.82829469
90	Cupped ear (HP:0000378)	1.82653076
91	Abnormality of alanine metabolism (HP:0010916)	1.81469748
92	Hyperalaninemia (HP:0003348)	1.81469748
93	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.81469748
94	Abnormality of renal resorption (HP:0011038)	1.81271090
95	Amelogenesis imperfecta (HP:0000705)	1.79314804
96	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.79081598
97	Bicornuate uterus (HP:0000813)	1.78427153
98	Bilateral microphthalmos (HP:0007633)	1.77356246
99	Sclerocornea (HP:0000647)	1.72905424
100	Abnormality of the fovea (HP:0000493)	1.72824977

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.18289040
2	TRIM28	3.59452099
3	MST4	3.58813449
4	MAPK13	3.04135755
5	ZAK	2.90263547
6	WNK3	2.56594074
7	MAP4K2	2.51737702
8	TLK1	2.31288020
9	SIK3	2.24474018
10	ADRBK2	2.12358966
11	ACVR1B	2.11627623
12	BMPR1B	2.05233060
13	NUAK1	2.05143980
14	TAOK3	1.95275041
15	GRK1	1.93078998
16	STK3	1.73214840
17	PTK2B	1.57932997
18	BCR	1.46847267
19	PINK1	1.42778177
20	PAK3	1.41616538
21	TNIK	1.41323661
22	PKN1	1.36140838
23	LATS1	1.35174970
24	MARK1	1.28119209
25	FER	1.22324520
26	DAPK2	1.17798720
27	STK39	1.15454457
28	PHKG2	1.11074617
29	PHKG1	1.11074617
30	OXSR1	1.09713636
31	MAP3K4	1.05961242
32	TNK2	1.01078717
33	CASK	1.00318174
34	LIMK1	0.99336514
35	NTRK3	0.99143346
36	TXK	0.94615292
37	IRAK1	0.91038952
38	CAMK2D	0.87900680
39	MKNK2	0.87634355
40	LMTK2	0.85950677
41	TEC	0.85549767
42	CSNK1G1	0.79415708
43	NEK2	0.76544798
44	INSRR	0.75696037
45	GRK5	0.74264472
46	PRKCE	0.72673215
47	ADRBK1	0.71762261
48	PRKCG	0.71357395
49	MARK3	0.69845281
50	PIK3CG	0.65466418
51	CSNK1G2	0.65050072
52	CSF1R	0.64286583
53	CSNK1G3	0.63883209
54	MAP2K7	0.63836579
55	STK11	0.61120273
56	KIT	0.60646063
57	IKBKB	0.58581159
58	VRK1	0.57895946
59	RPS6KB1	0.55953023
60	SYK	0.55759394
61	KSR1	0.55296828
62	PRKCI	0.55207843
63	PDK2	0.53731791
64	PLK4	0.52958490
65	CAMK2A	0.51478726
66	PBK	0.50658124
67	FGFR2	0.48995822
68	MAP4K1	0.47061477
69	PLK2	0.46510984
70	CAMK1	0.44843600
71	CSNK1A1L	0.43472632
72	PRKACA	0.43330317
73	WNK4	0.43179997
74	IRAK2	0.42842626
75	PLK3	0.42841694
76	CAMK4	0.41199154
77	CSNK1A1	0.40744535
78	MYLK	0.40337317
79	CDK19	0.38947237
80	TAOK1	0.38830027
81	TIE1	0.38566579
82	MKNK1	0.37331157
83	STK16	0.37285770
84	PRKD2	0.37218989
85	MAP3K7	0.36072933
86	MAP2K1	0.35867707
87	CSNK1D	0.35462371
88	BTK	0.35229087
89	PRKAA1	0.35045490
90	TRPM7	0.34290542
91	PRKCQ	0.33238699
92	OBSCN	0.32889755
93	PRKCB	0.32135508
94	DYRK2	0.32016590
95	TGFBR1	0.32006980
96	ROCK1	0.31751503
97	MINK1	0.31732222
98	PRKACG	0.30474114
99	PRKCZ	0.28887012
100	PRKACB	0.28749974

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.10961362
2	Phototransduction_Homo sapiens_hsa04744	2.91888075
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.74037374
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.71034104
5	Basal transcription factors_Homo sapiens_hsa03022	2.50778529
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.45377330
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.26427451
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.19953594
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.13443734
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02254685
11	ABC transporters_Homo sapiens_hsa02010	1.99956743
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.94760533
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.91043035
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86309638
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76775068
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.71923744
17	Circadian entrainment_Homo sapiens_hsa04713	1.66388322
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59124918
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.58847162
20	Olfactory transduction_Homo sapiens_hsa04740	1.57327239
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.55492239
22	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.55109635
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.52117053
24	Fatty acid elongation_Homo sapiens_hsa00062	1.49501834
25	Taste transduction_Homo sapiens_hsa04742	1.43540203
26	Retinol metabolism_Homo sapiens_hsa00830	1.41721079
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.38320301
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.35020500
29	Peroxisome_Homo sapiens_hsa04146	1.34348734
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.31483139
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.31432751
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31266820
33	Serotonergic synapse_Homo sapiens_hsa04726	1.28840074
34	Nicotine addiction_Homo sapiens_hsa05033	1.18068516
35	Platelet activation_Homo sapiens_hsa04611	1.14209330
36	Homologous recombination_Homo sapiens_hsa03440	1.12914391
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.12735458
38	Fatty acid metabolism_Homo sapiens_hsa01212	1.12015366
39	Propanoate metabolism_Homo sapiens_hsa00640	1.09590715
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.09001968
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08827642
42	Renin-angiotensin system_Homo sapiens_hsa04614	1.08537064
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.08163918
44	Amphetamine addiction_Homo sapiens_hsa05031	1.06066350
45	Insulin secretion_Homo sapiens_hsa04911	1.05131225
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.03128918
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.00811901
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.98616261
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.98570337
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98510501
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.97186595
52	Fatty acid degradation_Homo sapiens_hsa00071	0.96516266
53	Morphine addiction_Homo sapiens_hsa05032	0.95645449
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.92850047
55	Protein export_Homo sapiens_hsa03060	0.91606742
56	Caffeine metabolism_Homo sapiens_hsa00232	0.86157532
57	Gastric acid secretion_Homo sapiens_hsa04971	0.85139222
58	Regulation of autophagy_Homo sapiens_hsa04140	0.84826049
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81546730
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78859621
61	One carbon pool by folate_Homo sapiens_hsa00670	0.77781852
62	Sphingolipid metabolism_Homo sapiens_hsa00600	0.76638915
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75413831
64	RNA polymerase_Homo sapiens_hsa03020	0.75104409
65	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.75079020
66	Fanconi anemia pathway_Homo sapiens_hsa03460	0.73223776
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.73054645
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.68331139
69	Dopaminergic synapse_Homo sapiens_hsa04728	0.68305123
70	GABAergic synapse_Homo sapiens_hsa04727	0.68251025
71	Salivary secretion_Homo sapiens_hsa04970	0.65170505
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63265670
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.60975423
74	Oxidative phosphorylation_Homo sapiens_hsa00190	0.60084394
75	Purine metabolism_Homo sapiens_hsa00230	0.59131940
76	Circadian rhythm_Homo sapiens_hsa04710	0.57547923
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55394322
78	Cholinergic synapse_Homo sapiens_hsa04725	0.53447355
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51926541
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49546654
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.48788569
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48601379
83	Metabolic pathways_Homo sapiens_hsa01100	0.48353314
84	Long-term depression_Homo sapiens_hsa04730	0.47942961
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47921003
86	Parkinsons disease_Homo sapiens_hsa05012	0.45122892
87	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.44604857
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.42224991
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41645764
90	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.38564080
91	Renin secretion_Homo sapiens_hsa04924	0.35929771
92	Oocyte meiosis_Homo sapiens_hsa04114	0.35826162
93	Glutathione metabolism_Homo sapiens_hsa00480	0.35464690
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34743917
95	Pancreatic secretion_Homo sapiens_hsa04972	0.34322081
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.33321228
97	Sulfur metabolism_Homo sapiens_hsa00920	0.32981278
98	RNA degradation_Homo sapiens_hsa03018	0.32614003
99	Graft-versus-host disease_Homo sapiens_hsa05332	0.32302206
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.32227455

MARK2P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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