MARK2P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K27 methylation (GO:0061085)8.58174815
2regulation of glycoprotein biosynthetic process (GO:0010559)6.81453133
3L-fucose metabolic process (GO:0042354)6.49185074
4L-fucose catabolic process (GO:0042355)6.49185074
5fucose catabolic process (GO:0019317)6.49185074
6B cell proliferation (GO:0042100)6.32302648
7mRNA cleavage (GO:0006379)5.71195423
8regulation of glycoprotein metabolic process (GO:1903018)5.68262567
9intra-S DNA damage checkpoint (GO:0031573)5.68190216
10detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.44353383
11N-terminal protein amino acid acetylation (GO:0006474)5.34373380
12positive regulation of vesicle fusion (GO:0031340)5.29517752
13post-embryonic morphogenesis (GO:0009886)5.21688642
14peptidyl-lysine trimethylation (GO:0018023)5.19950881
15regulation of gene expression by genetic imprinting (GO:0006349)5.18447179
16pericardium development (GO:0060039)5.11787361
17positive regulation of mRNA 3-end processing (GO:0031442)5.04684068
18mature B cell differentiation (GO:0002335)5.02132766
19negative regulation of JNK cascade (GO:0046329)4.98942839
20acrosome assembly (GO:0001675)4.81024114
21deoxyribose phosphate biosynthetic process (GO:0046385)4.62744217
222-deoxyribonucleotide biosynthetic process (GO:0009265)4.62744217
23negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)4.62311355
24negative regulation of stress-activated MAPK cascade (GO:0032873)4.62311355
25fucosylation (GO:0036065)4.51096841
26relaxation of smooth muscle (GO:0044557)4.48851690
27retinal rod cell development (GO:0046548)4.37106721
28regulation of mRNA 3-end processing (GO:0031440)4.35782946
29single strand break repair (GO:0000012)4.35765287
30lateral ventricle development (GO:0021670)4.16554418
31transcription from mitochondrial promoter (GO:0006390)4.16224384
32cellular response to nitric oxide (GO:0071732)4.13122078
33male meiosis (GO:0007140)4.11310093
34regulation of DNA damage checkpoint (GO:2000001)4.01414224
35positive regulation of DNA-templated transcription, initiation (GO:2000144)3.97878159
36coronary vasculature morphogenesis (GO:0060977)3.94245147
37histone H3-K9 modification (GO:0061647)3.90568623
38pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.82639696
397-methylguanosine mRNA capping (GO:0006370)3.82396191
40detection of chemical stimulus involved in sensory perception (GO:0050907)3.74003115
41histone H3 deacetylation (GO:0070932)3.73637295
42pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.72687386
43UMP biosynthetic process (GO:0006222)3.72687386
44pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.72687386
45UMP metabolic process (GO:0046049)3.72687386
46regulation of hydrogen peroxide metabolic process (GO:0010310)3.72172199
47gene silencing by RNA (GO:0031047)3.71221732
487-methylguanosine RNA capping (GO:0009452)3.70677115
49RNA capping (GO:0036260)3.70677115
50DNA ligation (GO:0006266)3.68031073
51deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.66783118
52positive regulation of gluconeogenesis (GO:0045722)3.63883928
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.62660754
54pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.61930219
55deoxyribonucleotide biosynthetic process (GO:0009263)3.60937740
56binding of sperm to zona pellucida (GO:0007339)3.59458880
57fucose metabolic process (GO:0006004)3.56178526
58negative regulation of Rho protein signal transduction (GO:0035024)3.55218816
59pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.53040466
60microtubule severing (GO:0051013)3.47048622
61positive regulation of protein homodimerization activity (GO:0090073)3.40970235
62multicellular organism reproduction (GO:0032504)3.40851659
63nucleoside diphosphate biosynthetic process (GO:0009133)3.40762794
64regulation of oxidative phosphorylation (GO:0002082)3.39517663
65genetic imprinting (GO:0071514)3.37893131
66cellular response to virus (GO:0098586)3.34734076
67metallo-sulfur cluster assembly (GO:0031163)3.31408641
68iron-sulfur cluster assembly (GO:0016226)3.31408641
69response to nitric oxide (GO:0071731)3.30876850
70definitive hemopoiesis (GO:0060216)3.28354440
71positive regulation of mRNA processing (GO:0050685)3.25901644
72lymphocyte proliferation (GO:0046651)3.24365351
73regulation of DNA-templated transcription, initiation (GO:2000142)3.23095517
74positive regulation of T cell cytokine production (GO:0002726)3.21336728
75somatic stem cell division (GO:0048103)3.19967318
76detection of chemical stimulus (GO:0009593)3.19605172
77DNA replication checkpoint (GO:0000076)3.19032701
78N-terminal protein amino acid modification (GO:0031365)3.16435115
79mononuclear cell proliferation (GO:0032943)3.15894758
80embryonic process involved in female pregnancy (GO:0060136)3.15085319
81DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.12240838
82mature B cell differentiation involved in immune response (GO:0002313)3.11065121
83diacylglycerol metabolic process (GO:0046339)3.08369699
84sperm-egg recognition (GO:0035036)3.07923152
85peptidyl-lysine methylation (GO:0018022)3.07395964
86negative regulation of smooth muscle contraction (GO:0045986)3.06771800
87viral entry into host cell (GO:0046718)3.04321715
88detection of light stimulus involved in visual perception (GO:0050908)3.04050720
89detection of light stimulus involved in sensory perception (GO:0050962)3.04050720
90regulation of immunoglobulin secretion (GO:0051023)2.97671396
91cell-cell recognition (GO:0009988)2.97252215
92leukocyte proliferation (GO:0070661)2.93489746
93signal peptide processing (GO:0006465)2.93001693
94positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.92416703
95regulation of receptor binding (GO:1900120)2.89353319
96regulation of female receptivity (GO:0045924)2.88414143
97melanin biosynthetic process (GO:0042438)2.87980264
98negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.82923563
99positive regulation of mRNA metabolic process (GO:1903313)2.82612978
100regulation of protein glycosylation (GO:0060049)16.2319084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.63556224
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.09427010
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.89992933
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.25332611
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.95278944
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.95258492
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69838938
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63769416
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.63769416
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.54020320
11AUTS2_25519132_ChIP-Seq_293T-REX_Human2.51242252
12BCAT_22108803_ChIP-Seq_LS180_Human2.19214276
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09312258
14AR_21909140_ChIP-Seq_LNCAP_Human2.02106798
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01906239
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse10.5896796
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99579938
18MYC_18940864_ChIP-ChIP_HL60_Human1.92811912
19PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.67049135
20CBP_20019798_ChIP-Seq_JUKART_Human1.65959217
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65959217
22P53_22127205_ChIP-Seq_FIBROBLAST_Human1.65407055
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.64103705
24AR_20517297_ChIP-Seq_VCAP_Human1.60085020
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.58270624
26PRDM14_20953172_ChIP-Seq_ESCs_Human1.57377343
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56244466
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54797445
29IGF1R_20145208_ChIP-Seq_DFB_Human1.53904079
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49837416
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49574526
32IRF1_19129219_ChIP-ChIP_H3396_Human1.48580577
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39176443
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36039758
35PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.35818218
36BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29981866
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16398818
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15987296
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15681277
40P300_19829295_ChIP-Seq_ESCs_Human1.14323567
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11382877
42E2F1_20622854_ChIP-Seq_HELA_Human1.07469074
43CBP_21632823_ChIP-Seq_H3396_Human1.06355887
44TCF4_22108803_ChIP-Seq_LS180_Human1.05569648
45SCL_19346495_ChIP-Seq_HPC-7_Human1.04765521
46FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04487906
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.01842432
48BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.97281280
49TCF4_23295773_ChIP-Seq_U87_Human0.96614659
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95516868
51EWS_26573619_Chip-Seq_HEK293_Human0.94848971
52TCF4_18268006_ChIP-ChIP_LS174T_Human0.94446095
53CDX2_22108803_ChIP-Seq_LS180_Human0.93858412
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93581545
55GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93496307
56NANOG_19829295_ChIP-Seq_ESCs_Human0.92308095
57SOX2_19829295_ChIP-Seq_ESCs_Human0.92308095
58FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92212373
59FOXA1_25329375_ChIP-Seq_VCAP_Human0.92212373
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90590318
61ER_23166858_ChIP-Seq_MCF-7_Human0.90344426
62KDM5A_27292631_Chip-Seq_BREAST_Human0.85937390
63MYC_19829295_ChIP-Seq_ESCs_Human0.85742422
64GATA3_26560356_Chip-Seq_TH2_Human0.84557719
65NANOG_20526341_ChIP-Seq_ESCs_Human0.84518879
66CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84081072
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82099170
68P300_27268052_Chip-Seq_Bcells_Human0.80744545
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80492655
70PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80315695
71OCT1_27270436_Chip-Seq_PROSTATE_Human0.80146312
72HOXB7_26014856_ChIP-Seq_BT474_Human0.79525446
73FOXA1_25552417_ChIP-Seq_VCAP_Human0.79303388
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76649898
75ETS1_20019798_ChIP-Seq_JURKAT_Human0.76577135
76P53_21459846_ChIP-Seq_SAOS-2_Human0.76253976
77AHR_22903824_ChIP-Seq_MCF-7_Human0.76105363
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75450844
79GATA3_21878914_ChIP-Seq_MCF-7_Human0.75094351
80FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74285714
81GATA3_26560356_Chip-Seq_TH1_Human0.74141505
82TP63_23658742_ChIP-Seq_EP156T_Human0.73803785
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71861320
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70905613
85KLF4_18555785_Chip-Seq_ESCs_Mouse0.70269055
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.70062794
87STAT3_23295773_ChIP-Seq_U87_Human0.69951995
88CEBPB_22108803_ChIP-Seq_LS180_Human0.69730075
89MYB_26560356_Chip-Seq_TH2_Human0.69304056
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.68869559
91RUNX1_22412390_ChIP-Seq_EML_Mouse0.68315452
92TP53_18474530_ChIP-ChIP_U2OS_Human0.67718566
93TP53_22127205_ChIP-Seq_IMR90_Human0.67449156
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.66754000
95NCOR_22424771_ChIP-Seq_293T_Human0.65556161
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65497690
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.65080764
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.64754375
99TP53_22573176_ChIP-Seq_HFKS_Human0.63720804
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.62386093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane7.44385072
2MP0002653_abnormal_ependyma_morphology5.93531404
3MP0005360_urolithiasis4.21526810
4MP0009840_abnormal_foam_cell3.79381517
5MP0005410_abnormal_fertilization3.19597803
6MP0002877_abnormal_melanocyte_morpholog2.90664171
7MP0001984_abnormal_olfaction2.76629529
8MP0000372_irregular_coat_pigmentation2.70530668
9MP0010094_abnormal_chromosome_stability2.60498251
10MP0000383_abnormal_hair_follicle2.55159707
11MP0008877_abnormal_DNA_methylation2.46069674
12MP0000371_diluted_coat_color2.29145344
13MP0002160_abnormal_reproductive_system2.25930607
14MP0005670_abnormal_white_adipose2.22706141
15MP0010678_abnormal_skin_adnexa2.16031579
16MP0003718_maternal_effect2.13024930
17MP0000427_abnormal_hair_cycle2.12191444
18MP0003315_abnormal_perineum_morphology2.04606916
19MP0003136_yellow_coat_color1.95899918
20MP0004782_abnormal_surfactant_physiolog1.87638920
21MP0002138_abnormal_hepatobiliary_system1.83993449
22MP0003878_abnormal_ear_physiology1.81005409
23MP0005377_hearing/vestibular/ear_phenot1.81005409
24MP0009697_abnormal_copulation1.78026356
25MP0008057_abnormal_DNA_replication1.67025033
26MP0001348_abnormal_lacrimal_gland1.66849131
27MP0008961_abnormal_basal_metabolism1.61319088
28MP0000647_abnormal_sebaceous_gland1.54980653
29MP0000465_gastrointestinal_hemorrhage1.54466895
30MP0005171_absent_coat_pigmentation1.54253762
31MP0005248_abnormal_Harderian_gland1.49533405
32MP0008004_abnormal_stomach_pH1.47649354
33MP0005409_darkened_coat_color1.44005873
34MP0002734_abnormal_mechanical_nocicepti1.37012455
35MP0005379_endocrine/exocrine_gland_phen1.36179435
36MP0008058_abnormal_DNA_repair1.35615926
37MP0001929_abnormal_gametogenesis1.33704050
38MP0001661_extended_life_span1.31221422
39MP0008789_abnormal_olfactory_epithelium1.30210428
40MP0002127_abnormal_cardiovascular_syste1.25031613
41MP0005389_reproductive_system_phenotype1.24708241
42MP0002736_abnormal_nociception_after1.20557533
43MP0003787_abnormal_imprinting1.13260136
44MP0005501_abnormal_skin_physiology1.12929324
45MP0000678_abnormal_parathyroid_gland1.12815238
46MP0005499_abnormal_olfactory_system1.12678450
47MP0005394_taste/olfaction_phenotype1.12678450
48MP0009053_abnormal_anal_canal1.08673289
49MP0003186_abnormal_redox_activity1.06386399
50MP0003045_fibrosis1.04165221
51MP0001186_pigmentation_phenotype1.02676038
52MP0002452_abnormal_antigen_presenting1.02190785
53MP0003890_abnormal_embryonic-extraembry1.02189843
54MP0002075_abnormal_coat/hair_pigmentati1.01542843
55MP0001501_abnormal_sleep_pattern0.99971085
56MP0002148_abnormal_hypersensitivity_rea0.99637286
57MP0005174_abnormal_tail_pigmentation0.99374487
58MP0003191_abnormal_cellular_cholesterol0.97177396
59MP0003698_abnormal_male_reproductive0.96336857
60MP0003077_abnormal_cell_cycle0.95618790
61MP0001835_abnormal_antigen_presentation0.93430333
62MP0001188_hyperpigmentation0.90135874
63MP0001819_abnormal_immune_cell0.89354611
64MP0003111_abnormal_nucleus_morphology0.89347647
65MP0005387_immune_system_phenotype0.87403953
66MP0001790_abnormal_immune_system0.87403953
67MP0003172_abnormal_lysosome_physiology0.86324867
68MP0002420_abnormal_adaptive_immunity0.84893928
69MP0004381_abnormal_hair_follicle0.83780832
70MP0000716_abnormal_immune_system0.81735212
71MP0000230_abnormal_systemic_arterial0.81187301
72MP0002398_abnormal_bone_marrow0.79659475
73MP0002971_abnormal_brown_adipose0.78843761
74MP0004808_abnormal_hematopoietic_stem0.78125215
75MP0001879_abnormal_lymphatic_vessel0.77730482
76MP0002723_abnormal_immune_serum0.75834806
77MP0005646_abnormal_pituitary_gland0.75167229
78MP0002429_abnormal_blood_cell0.73694558
79MP0008875_abnormal_xenobiotic_pharmacok0.73496588
80MP0000015_abnormal_ear_pigmentation0.72249368
81MP0010234_abnormal_vibrissa_follicle0.70791929
82MP0005584_abnormal_enzyme/coenzyme_acti0.70702717
83MP0005395_other_phenotype0.69734890
84MP0001191_abnormal_skin_condition0.69270457
85MP0002210_abnormal_sex_determination0.69245806
86MP0001730_embryonic_growth_arrest0.68376984
87MP0005551_abnormal_eye_electrophysiolog0.68209912
88MP0001119_abnormal_female_reproductive0.68187009
89MP0001968_abnormal_touch/_nociception0.67644981
90MP0000470_abnormal_stomach_morphology0.66950348
91MP0001800_abnormal_humoral_immune0.65321755
92MP0002086_abnormal_extraembryonic_tissu0.64863185
93MP0003183_abnormal_peptide_metabolism0.62977422
94MP0003724_increased_susceptibility_to0.60389761
95MP0003786_premature_aging0.59302374
96MP0003119_abnormal_digestive_system0.58097061
97MP0003879_abnormal_hair_cell0.57582661
98MP0006276_abnormal_autonomic_nervous0.57332328
99MP0004215_abnormal_myocardial_fiber0.55216648
100MP0000490_abnormal_crypts_of0.54802752

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)7.25264469
2Spinal rigidity (HP:0003306)6.63835638
3Transposition of the great arteries (HP:0001669)5.29986478
4Abnormal connection of the cardiac segments (HP:0011545)5.29986478
5Abnormal ventriculo-arterial connection (HP:0011563)5.29986478
6Abnormality of the calf musculature (HP:0001430)5.29716780
7Entropion (HP:0000621)4.49196425
8Poikiloderma (HP:0001029)4.25195130
9Abnormality of the vitreous humor (HP:0004327)4.22155862
10Abnormality of DNA repair (HP:0003254)4.19709469
11Aplasia/Hypoplasia of the brainstem (HP:0007362)3.97366121
12Hypoplasia of the brainstem (HP:0002365)3.97366121
13Lissencephaly (HP:0001339)3.91756915
14Meningocele (HP:0002435)3.83171396
15Morphological abnormality of the pyramidal tract (HP:0002062)3.79822133
16Metaphyseal dysplasia (HP:0100255)3.78619986
17Lip pit (HP:0100267)3.70474081
18Lymphopenia (HP:0001888)3.69541193
19Emphysema (HP:0002097)3.69155434
20Muscular dystrophy (HP:0003560)3.60615039
21Vasculitis (HP:0002633)3.43909206
22Gowers sign (HP:0003391)3.37368930
23Non-midline cleft lip (HP:0100335)3.29568639
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.16277292
25Restrictive lung disease (HP:0002091)3.00004131
26Pulmonic stenosis (HP:0001642)2.92414682
27Pachygyria (HP:0001302)2.84094668
28Porencephaly (HP:0002132)2.76959415
29Facial hemangioma (HP:0000329)2.55784039
30Leukopenia (HP:0001882)2.54198141
31Posterior subcapsular cataract (HP:0007787)2.47287670
32Recurrent sinusitis (HP:0011108)2.47077588
33Amelogenesis imperfecta (HP:0000705)2.42186458
34Absent/shortened dynein arms (HP:0200106)2.36626435
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.36626435
36Poor head control (HP:0002421)2.33567713
37Keratitis (HP:0000491)2.30892799
38Cutaneous melanoma (HP:0012056)2.25149403
39Epiphyseal dysplasia (HP:0002656)2.21587562
403-Methylglutaconic aciduria (HP:0003535)2.20939056
41Polymicrogyria (HP:0002126)2.14167508
42Ectropion (HP:0000656)2.01043064
43Calf muscle hypertrophy (HP:0008981)12.6624100
44Type II lissencephaly (HP:0007260)12.6368717
45Muscle hypertrophy of the lower extremities (HP:0008968)11.1987709
46Retinal dysplasia (HP:0007973)10.3372871
47Concave nail (HP:0001598)1.98725272
48Dandy-Walker malformation (HP:0001305)1.97497953
49Holoprosencephaly (HP:0001360)1.96578579
50Capillary hemangiomas (HP:0005306)1.95894591
51Keratoconjunctivitis sicca (HP:0001097)1.94373582
52Abnormality of chromosome stability (HP:0003220)1.88881268
53Hypoplasia of the uterus (HP:0000013)1.87626121
54Retinal detachment (HP:0000541)1.87286118
55Congenital sensorineural hearing impairment (HP:0008527)1.87062447
56Aplasia/Hypoplasia of the uvula (HP:0010293)1.79710465
57Keratoconjunctivitis (HP:0001096)1.76342218
58Sparse lateral eyebrow (HP:0005338)1.74917360
59Abolished electroretinogram (ERG) (HP:0000550)1.73377132
60Abnormality of dental color (HP:0011073)1.72835218
61Decreased central vision (HP:0007663)1.69935780
62Inflammation of the large intestine (HP:0002037)1.66981838
63Reduced antithrombin III activity (HP:0001976)1.66545876
64Abnormal ciliary motility (HP:0012262)1.65573951
65Abnormal number of erythroid precursors (HP:0012131)1.64609234
66Abnormality of the preputium (HP:0100587)1.62377037
67Congenital stationary night blindness (HP:0007642)1.61752328
68Lymphoma (HP:0002665)1.61127243
69Meckel diverticulum (HP:0002245)1.59135053
70Prolonged neonatal jaundice (HP:0006579)1.57300883
71Clubbing of toes (HP:0100760)1.57121567
72Acute myeloid leukemia (HP:0004808)1.55532027
73Median cleft lip (HP:0000161)1.53455235
74Cerebellar hypoplasia (HP:0001321)1.50723247
75Lipoatrophy (HP:0100578)1.50666145
76Abnormality of the ileum (HP:0001549)1.49742771
77Gastrointestinal inflammation (HP:0004386)1.49004239
78Optic neuritis (HP:0100653)1.46660400
79Retrobulbar optic neuritis (HP:0100654)1.46660400
80Abnormality of cells of the erythroid lineage (HP:0012130)1.44861430
81Bony spicule pigmentary retinopathy (HP:0007737)1.43596858
82Ectopic kidney (HP:0000086)1.42380555
83Squamous cell carcinoma (HP:0002860)1.37866102
84Polar cataract (HP:0010696)1.34817175
85Duodenal stenosis (HP:0100867)1.30731974
86Small intestinal stenosis (HP:0012848)1.30731974
87Cleft eyelid (HP:0000625)1.30690665
88Cerebellar dysplasia (HP:0007033)1.30540605
89Abnormality of cochlea (HP:0000375)1.29440173
90Photophobia (HP:0000613)1.29435173
91Follicular hyperkeratosis (HP:0007502)1.29169737
92Spastic tetraparesis (HP:0001285)1.28559962
93Colitis (HP:0002583)1.28110346
94Abnormal respiratory motile cilium physiology (HP:0012261)1.26139254
95Spontaneous hematomas (HP:0007420)1.24568491
96Abnormal umbilical cord blood vessels (HP:0011403)1.23982549
97Single umbilical artery (HP:0001195)1.23982549
98Abnormality of the fetal cardiovascular system (HP:0010948)1.23982549
99Hypermetropia (HP:0000540)1.23786496
100Fibular hypoplasia (HP:0003038)1.23115599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF2.94950669
2PINK12.94408289
3MARK32.48901114
4SIK32.37821379
5MAP3K92.23818239
6TRIM282.15418406
7CDK1913.2591334
8TEC1.93863190
9MAP3K101.75290618
10MAP3K131.53066793
11BMPR21.29957407
12RPS6KB11.25324298
13STK31.21656561
14EIF2AK21.18892668
15MYLK1.06828245
16MAPK111.05229769
17MOS1.04118809
18MST1R1.03488834
19BRAF1.02265276
20NTRK21.02177406
21WEE10.99044644
22ADRBK20.98186877
23ERBB30.96987539
24BTK0.96633176
25MAP2K60.94852102
26ITK0.87438118
27CDK120.85946773
28NME10.81164091
29RIPK40.77052829
30KSR10.73753358
31NUAK10.73042992
32MST40.69026530
33ZAK0.67535643
34PRKCZ0.64334338
35SYK0.64150892
36ICK0.63825369
37CAMK2D0.62483171
38RPS6KA50.61739656
39MATK0.56705121
40TAOK30.56008542
41IRAK40.55833117
42GRK60.55550032
43MINK10.55444743
44PTK2B0.54071892
45GRK10.53115640
46CDK11A0.52321577
47MARK20.50561479
48AURKB0.50521314
49KSR20.50166258
50DYRK30.49531030
51BUB10.46347414
52CDK40.45861544
53ATR0.44662750
54PRKCB0.44092904
55PRKCQ0.43625306
56FRK0.43029276
57NEK20.42403914
58PDPK10.42105677
59BMPR1B0.41986855
60PDK10.41157436
61MAP2K10.40545741
62RAF10.40497407
63RPS6KA40.39306419
64CSNK2A20.37436073
65MAP2K20.37326993
66CAMK2B0.36830470
67TIE10.36787938
68CDK30.36667543
69BCR0.36354705
70MAPKAPK30.35408138
71EIF2AK30.34877432
72MTOR0.34178561
73TLK10.33992247
74MAPK10.33455648
75EEF2K0.33290468
76PDK20.33074915
77CHEK10.33037467
78CHEK20.32934251
79LATS10.31792566
80NEK10.30311252
81PRKG10.30202180
82CDK70.29234753
83CSNK1A1L0.28957597
84CDK60.28836845
85PBK0.28725416
86AKT20.27838420
87ATM0.27806528
88CDK140.26502321
89CSNK1G30.24448452
90CDK90.23979962
91VRK10.23436457
92MUSK0.23209402
93ABL10.23086906
94CSNK2A10.22767851
95EIF2AK10.22426474
96CDK10.21621783
97OBSCN0.20923652
98MELK0.20810801
99PLK10.20492504
100MAPK30.20447907

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose phosphate pathway_Homo sapiens_hsa000308.52121177
2Olfactory transduction_Homo sapiens_hsa047404.12225258
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.49278929
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.86464544
5Hematopoietic cell lineage_Homo sapiens_hsa046402.81668268
6Asthma_Homo sapiens_hsa053102.73241006
7mRNA surveillance pathway_Homo sapiens_hsa030152.56973429
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.50053932
9Biosynthesis of amino acids_Homo sapiens_hsa012302.05148039
10Allograft rejection_Homo sapiens_hsa053301.80817176
11Autoimmune thyroid disease_Homo sapiens_hsa053201.75260891
12Graft-versus-host disease_Homo sapiens_hsa053321.68629839
13Non-homologous end-joining_Homo sapiens_hsa034501.54518535
14RNA transport_Homo sapiens_hsa030131.51241411
15RNA polymerase_Homo sapiens_hsa030201.49196657
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.49010796
17Phagosome_Homo sapiens_hsa041451.38262346
18Chemical carcinogenesis_Homo sapiens_hsa052041.30637361
19Gap junction_Homo sapiens_hsa045401.28850327
20Nucleotide excision repair_Homo sapiens_hsa034201.23972525
21Type I diabetes mellitus_Homo sapiens_hsa049401.22116357
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17784123
23Notch signaling pathway_Homo sapiens_hsa043301.16768757
24Oocyte meiosis_Homo sapiens_hsa041141.16514390
25Systemic lupus erythematosus_Homo sapiens_hsa053221.11260161
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10760933
27Carbon metabolism_Homo sapiens_hsa012001.09934096
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09562025
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09300502
30Primary immunodeficiency_Homo sapiens_hsa053401.09114871
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07301040
32Basal transcription factors_Homo sapiens_hsa030221.06825070
33Pyrimidine metabolism_Homo sapiens_hsa002401.06547437
34Dorso-ventral axis formation_Homo sapiens_hsa043201.03188255
35Herpes simplex infection_Homo sapiens_hsa051681.02283049
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.02237739
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01103857
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98555374
39p53 signaling pathway_Homo sapiens_hsa041150.91786676
40Staphylococcus aureus infection_Homo sapiens_hsa051500.90882085
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90333491
42RNA degradation_Homo sapiens_hsa030180.86619765
43Sulfur metabolism_Homo sapiens_hsa009200.85076803
44Phototransduction_Homo sapiens_hsa047440.82014047
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76239778
46Fanconi anemia pathway_Homo sapiens_hsa034600.75148952
47Rheumatoid arthritis_Homo sapiens_hsa053230.74574384
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73339215
49ECM-receptor interaction_Homo sapiens_hsa045120.71763375
50Lysine degradation_Homo sapiens_hsa003100.71552079
51HTLV-I infection_Homo sapiens_hsa051660.71299081
52Glutathione metabolism_Homo sapiens_hsa004800.68014861
53Cell cycle_Homo sapiens_hsa041100.67159878
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66136445
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65219852
56ABC transporters_Homo sapiens_hsa020100.61588805
57Glycerolipid metabolism_Homo sapiens_hsa005610.61031501
58Hedgehog signaling pathway_Homo sapiens_hsa043400.60242526
59Viral myocarditis_Homo sapiens_hsa054160.59965146
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.59485603
61Mismatch repair_Homo sapiens_hsa034300.58835473
62Antigen processing and presentation_Homo sapiens_hsa046120.57154180
63Nitrogen metabolism_Homo sapiens_hsa009100.56172251
64Spliceosome_Homo sapiens_hsa030400.54528049
65Retinol metabolism_Homo sapiens_hsa008300.54230325
66Legionellosis_Homo sapiens_hsa051340.53865494
67B cell receptor signaling pathway_Homo sapiens_hsa046620.53411796
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53153754
69Apoptosis_Homo sapiens_hsa042100.52974521
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48962511
71Toxoplasmosis_Homo sapiens_hsa051450.47818847
72DNA replication_Homo sapiens_hsa030300.46930567
73Leishmaniasis_Homo sapiens_hsa051400.45296072
74Starch and sucrose metabolism_Homo sapiens_hsa005000.44784570
75TGF-beta signaling pathway_Homo sapiens_hsa043500.43022155
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42447459
77Protein digestion and absorption_Homo sapiens_hsa049740.40656902
78Small cell lung cancer_Homo sapiens_hsa052220.39234399
79Melanoma_Homo sapiens_hsa052180.38207100
80Viral carcinogenesis_Homo sapiens_hsa052030.36715031
81Influenza A_Homo sapiens_hsa051640.36436456
82Protein export_Homo sapiens_hsa030600.36373361
83Epstein-Barr virus infection_Homo sapiens_hsa051690.33451107
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33031364
85Calcium signaling pathway_Homo sapiens_hsa040200.32974640
86Regulation of autophagy_Homo sapiens_hsa041400.31791788
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30552599
88Alcoholism_Homo sapiens_hsa050340.29487929
89Metabolic pathways_Homo sapiens_hsa011000.27560827
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25776296
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.25296205
92One carbon pool by folate_Homo sapiens_hsa006700.25291288
93Histidine metabolism_Homo sapiens_hsa003400.23748278
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23172818
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.19627701
96Arginine and proline metabolism_Homo sapiens_hsa003300.19543101
97Lysosome_Homo sapiens_hsa041420.19509747
98Homologous recombination_Homo sapiens_hsa034400.19481360
99Fatty acid biosynthesis_Homo sapiens_hsa000610.17433651
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17088709

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