MARK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)3.97160994
2hippo signaling (GO:0035329)3.94904097
3nuclear pore complex assembly (GO:0051292)3.80998319
4regulation of RNA export from nucleus (GO:0046831)3.68923159
5histone H3-K4 trimethylation (GO:0080182)3.54091389
6paraxial mesoderm development (GO:0048339)3.53981629
7phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.50554167
8nuclear pore organization (GO:0006999)3.48190672
9peptidyl-lysine dimethylation (GO:0018027)3.40739448
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.32581711
11cytoplasmic mRNA processing body assembly (GO:0033962)3.25836195
12embryonic foregut morphogenesis (GO:0048617)3.22587527
13insulin-like growth factor receptor signaling pathway (GO:0048009)3.18913329
14regulation of nucleobase-containing compound transport (GO:0032239)3.17920449
15regulation of hippo signaling (GO:0035330)3.17618721
16negative regulation of erythrocyte differentiation (GO:0045647)3.13276426
17establishment of nucleus localization (GO:0040023)3.09983369
18gastrulation with mouth forming second (GO:0001702)3.05959648
19microglial cell activation (GO:0001774)3.05599624
20NLS-bearing protein import into nucleus (GO:0006607)3.03357242
21layer formation in cerebral cortex (GO:0021819)3.02656898
22histone H2A monoubiquitination (GO:0035518)3.00458181
23planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98972854
24regulation of translational fidelity (GO:0006450)2.98649660
25regulation of necroptotic process (GO:0060544)2.95459185
26mitotic sister chromatid cohesion (GO:0007064)2.92937997
27polarized epithelial cell differentiation (GO:0030859)2.91966249
28macrophage activation involved in immune response (GO:0002281)2.91787657
29oxygen transport (GO:0015671)2.88522917
30peptidyl-lysine trimethylation (GO:0018023)2.87147260
31histone H3-K9 modification (GO:0061647)2.86339356
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85527456
33histone H3-K9 demethylation (GO:0033169)2.85137603
34erythrocyte development (GO:0048821)2.84707671
35interkinetic nuclear migration (GO:0022027)2.83465661
36macroautophagy (GO:0016236)2.82726158
37adherens junction assembly (GO:0034333)2.82048955
38protoporphyrinogen IX metabolic process (GO:0046501)2.78782511
39protein K11-linked deubiquitination (GO:0035871)2.78555615
40growth hormone receptor signaling pathway (GO:0060396)2.78331631
41negative regulation of histone methylation (GO:0031061)2.78283818
42regulation of catenin import into nucleus (GO:0035412)2.72626943
43plasma membrane repair (GO:0001778)2.70955472
44glial cell proliferation (GO:0014009)2.70070587
45positive regulation of catenin import into nucleus (GO:0035413)2.66252882
46regulation of ARF protein signal transduction (GO:0032012)2.65990018
47positive regulation of SMAD protein import into nucleus (GO:0060391)2.62182907
48activated T cell proliferation (GO:0050798)2.60733818
49hepatocyte apoptotic process (GO:0097284)2.58806731
50negative regulation of catenin import into nucleus (GO:0035414)2.57676037
51pore complex assembly (GO:0046931)2.57549485
52negative regulation of DNA repair (GO:0045738)2.55210351
53regulation of glycogen (starch) synthase activity (GO:2000465)2.54690273
54N-terminal protein amino acid acetylation (GO:0006474)2.54391617
55cellular response to monoamine stimulus (GO:0071868)2.53841274
56cellular response to catecholamine stimulus (GO:0071870)2.53841274
57neutrophil mediated immunity (GO:0002446)2.53723141
58corticosteroid receptor signaling pathway (GO:0031958)2.52276762
59monoubiquitinated protein deubiquitination (GO:0035520)2.52081209
60lung-associated mesenchyme development (GO:0060484)2.52021347
61cellular response to growth hormone stimulus (GO:0071378)2.50995001
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50983823
63positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50949316
64heterochromatin organization (GO:0070828)2.50037579
65embryonic hemopoiesis (GO:0035162)2.49170215
66regulation of posttranscriptional gene silencing (GO:0060147)2.48874875
67regulation of gene silencing by miRNA (GO:0060964)2.48874875
68regulation of gene silencing by RNA (GO:0060966)2.48874875
69positive T cell selection (GO:0043368)2.48635641
70cerebellar Purkinje cell differentiation (GO:0021702)2.48508295
71peptidyl-lysine methylation (GO:0018022)2.47935027
72chondrocyte development (GO:0002063)2.47700457
73regulation of sister chromatid cohesion (GO:0007063)2.47651904
74ectodermal placode formation (GO:0060788)2.47334296
75regulation of histone H3-K9 methylation (GO:0051570)2.47140543
76establishment of apical/basal cell polarity (GO:0035089)2.46859230
77regulation of protein polyubiquitination (GO:1902914)2.46783075
78histone H3-K9 methylation (GO:0051567)2.46767527
79positive regulation of dendrite morphogenesis (GO:0050775)2.46747103
80nerve growth factor signaling pathway (GO:0038180)2.46640815
81regulation of SMAD protein import into nucleus (GO:0060390)2.46503873
82notochord development (GO:0030903)2.44890546
83axon extension (GO:0048675)2.44659186
84gas transport (GO:0015669)2.44509200
85histone H3-K36 demethylation (GO:0070544)2.44359611
86protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.42644336
87positive regulation of gamma-delta T cell activation (GO:0046645)2.42438413
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41914307
89negative regulation of cell killing (GO:0031342)2.41881750
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.41881750
91regulation of transforming growth factor beta2 production (GO:0032909)2.41788898
92peptidyl-threonine phosphorylation (GO:0018107)2.41293959
93lens fiber cell development (GO:0070307)2.41246381
94central nervous system projection neuron axonogenesis (GO:0021952)2.41099012
95positive regulation of receptor recycling (GO:0001921)2.38103695
96membrane tubulation (GO:0097320)2.38082672
97negative regulation of interleukin-12 production (GO:0032695)2.37541350
98anterior/posterior axis specification, embryo (GO:0008595)2.35941671
99negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.35783019
100regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.35584034
101camera-type eye morphogenesis (GO:0048593)2.34381478
102glucocorticoid receptor signaling pathway (GO:0042921)2.34060775
103chromatin assembly (GO:0031497)2.33840225
104epithelial cell differentiation involved in prostate gland development (GO:0060742)2.33324450
105negative regulation of neurotransmitter secretion (GO:0046929)2.32572671
106midgut development (GO:0007494)2.31542406
107histone H3-K4 methylation (GO:0051568)2.30923088
108dendrite morphogenesis (GO:0048813)2.30145014
109histone lysine demethylation (GO:0070076)2.29999453
110negative regulation of Rho protein signal transduction (GO:0035024)2.29875971
111establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.29385155
112establishment or maintenance of monopolar cell polarity (GO:0061339)2.28589881
113establishment of monopolar cell polarity (GO:0061162)2.28589881
114myeloid cell development (GO:0061515)2.28126979
115coronary vasculature morphogenesis (GO:0060977)2.27444184
116dorsal/ventral axis specification (GO:0009950)2.26582144
117iron ion import (GO:0097286)2.26393932
118interleukin-6-mediated signaling pathway (GO:0070102)2.26307167
119protein dealkylation (GO:0008214)2.25948580
120protein demethylation (GO:0006482)2.25948580
121response to methylmercury (GO:0051597)2.25631816
122regulation of cardioblast differentiation (GO:0051890)2.25009824
123protein K48-linked deubiquitination (GO:0071108)2.24072344
124hemoglobin metabolic process (GO:0020027)2.24021675
125Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.23239040
126semaphorin-plexin signaling pathway (GO:0071526)2.22967620
127neuron projection extension (GO:1990138)2.21660561
128germinal center formation (GO:0002467)2.21383782
129cellular response to ethanol (GO:0071361)2.21129319
130focal adhesion assembly (GO:0048041)2.21070664
131cell-substrate adherens junction assembly (GO:0007045)2.21070664
132neuron projection extension involved in neuron projection guidance (GO:1902284)2.20683991
133axon extension involved in axon guidance (GO:0048846)2.20683991
134macrophage activation (GO:0042116)2.20328228
135establishment of protein localization to Golgi (GO:0072600)2.20316669
136nucleus localization (GO:0051647)2.20075544
137response to muramyl dipeptide (GO:0032495)2.19920486
138dosage compensation (GO:0007549)2.19775082
139negative regulation of neurotransmitter transport (GO:0051589)2.19494672
140regulation of NFAT protein import into nucleus (GO:0051532)2.19003096
141histone lysine methylation (GO:0034968)2.18705433
142regulation of establishment of planar polarity (GO:0090175)2.18347659
143negative regulation of necroptotic process (GO:0060546)2.18318250
144adherens junction organization (GO:0034332)2.17640138
145gene silencing by RNA (GO:0031047)2.17615381
146regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.17062799
147negative regulation of potassium ion transmembrane transport (GO:1901380)2.16509404
148hypotonic response (GO:0006971)2.16432956
149histone demethylation (GO:0016577)2.16181859
150positive regulation of protein deacetylation (GO:0090312)2.15672686
151stress granule assembly (GO:0034063)2.15541771
152negative regulation of translation, ncRNA-mediated (GO:0040033)2.14723782
153regulation of translation, ncRNA-mediated (GO:0045974)2.14723782
154negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.14723782
155myeloid leukocyte mediated immunity (GO:0002444)2.14711714
156positive regulation of neuroblast proliferation (GO:0002052)2.13910142
157cell migration in hindbrain (GO:0021535)2.13803831
158positive regulation of hormone biosynthetic process (GO:0046886)2.13540556
159modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.13156292
160modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.13156292
161positive regulation by organism of defense response of other organism involved in symbiotic interact2.13156292
162modulation by symbiont of host immune response (GO:0052553)2.13156292
163positive regulation by symbiont of host defense response (GO:0052509)2.13156292
164modulation by symbiont of host defense response (GO:0052031)2.13156292
165negative regulation of chondrocyte differentiation (GO:0032331)2.12273629
166early endosome to late endosome transport (GO:0045022)2.11826678
167DNA unwinding involved in DNA replication (GO:0006268)2.11649600
168negative regulation of sodium ion transport (GO:0010766)2.11098136
169heart morphogenesis (GO:0003007)2.11050917
170peptidyl-threonine modification (GO:0018210)2.10778783
171neural tube closure (GO:0001843)2.10521218
172positive regulation of histone deacetylation (GO:0031065)2.10491269
173positive regulation of granulocyte differentiation (GO:0030854)2.10349218
174retrograde transport, vesicle recycling within Golgi (GO:0000301)2.10343062
175peptidyl-serine phosphorylation (GO:0018105)2.10232552
176negative regulation of cell size (GO:0045792)2.09764169
177peptidyl-arginine N-methylation (GO:0035246)2.09257052
178peptidyl-arginine methylation (GO:0018216)2.09257052
179regulation of erythrocyte differentiation (GO:0045646)2.08921917
180cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.08382721
181protein localization to endosome (GO:0036010)2.08324089
182spindle assembly involved in mitosis (GO:0090307)2.08003987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.63559241
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.34131438
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.29648731
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.20126229
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.85327774
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.76986660
7GATA1_22025678_ChIP-Seq_K562_Human2.70714396
8TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.68205821
9SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.51629816
10E2F7_22180533_ChIP-Seq_HELA_Human2.46659348
11SCL_19346495_ChIP-Seq_HPC-7_Human2.41497697
12EZH2_22144423_ChIP-Seq_EOC_Human2.41275391
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.38845960
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.33530038
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30982844
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.30872280
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.26691917
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26217891
19* CLOCK_20551151_ChIP-Seq_293T_Human2.16830579
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.03318371
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.01005764
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98767958
23* GATA1_19941826_ChIP-Seq_K562_Human1.97937665
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96584973
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.94227261
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.90747755
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88377102
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88150549
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87023048
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86918486
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.86436380
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80822137
33ZNF263_19887448_ChIP-Seq_K562_Human1.80746029
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.80175858
35FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.79848033
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.77455020
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74804413
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73731373
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72668816
40* KDM2B_26808549_Chip-Seq_DND41_Human1.70385288
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.70108617
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66036542
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62784295
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.62383838
45KDM2B_26808549_Chip-Seq_K562_Human1.60560578
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.59952452
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59457260
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59157300
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58561901
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55080919
51* GATA2_19941826_ChIP-Seq_K562_Human1.53466077
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52926873
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48471903
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47595712
55RUNX_20019798_ChIP-Seq_JUKART_Human1.47033728
56MYC_22102868_ChIP-Seq_BL_Human1.46731403
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45936392
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.44504823
59AHR_22903824_ChIP-Seq_MCF-7_Human1.42957348
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42579630
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40649745
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39771896
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.39295694
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39217076
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37285156
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.36614970
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36305783
68BRD4_25478319_ChIP-Seq_HGPS_Human1.36043343
69* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35332668
70* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.34229476
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31608473
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29436134
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29135793
74TP53_16413492_ChIP-PET_HCT116_Human1.28626119
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28583834
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.28322216
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.27954004
78* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27715634
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27240734
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.27152399
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26152404
82DROSHA_22980978_ChIP-Seq_HELA_Human1.26077513
83SPI1_23127762_ChIP-Seq_K562_Human1.25103893
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24614096
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23502740
86TCF7_22412390_ChIP-Seq_EML_Mouse1.22475180
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21146951
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.19728968
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18133452
90* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17495098
91CHD1_26751641_Chip-Seq_LNCaP_Human1.14532090
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.14141505
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13228808
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13175715
95AR_21909140_ChIP-Seq_LNCAP_Human1.13145399
96* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13074492
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12982512
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11805328
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11710809
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.11328270
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10865079
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09954060
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09831573
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09740791
105POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08970271
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.07787794
107VDR_24787735_ChIP-Seq_THP-1_Human1.07332570
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.07059868
109CREB1_26743006_Chip-Seq_LNCaP_Human1.06550928
110* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06015194
111* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05829766
112* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05381186
113ZNF274_21170338_ChIP-Seq_K562_Hela1.05352915
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05252136
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05252136
116TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03568115
117RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03256109
118VDR_24763502_ChIP-Seq_THP-1_Human1.03247871
119ATF3_27146783_Chip-Seq_COLON_Human1.03223011
120YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02201987
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02067061
122TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01920054
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.01769855
124TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01183303
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00503640
126SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00458978
127VDR_21846776_ChIP-Seq_THP-1_Human0.99290903
128SOX2_16153702_ChIP-ChIP_HESCs_Human0.99004232
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.98594095
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97038410
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96961402
132RARB_27405468_Chip-Seq_BRAIN_Mouse0.96927547
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96656353
134RUNX1_27514584_Chip-Seq_MCF-7_Human0.96146115
135RXR_22108803_ChIP-Seq_LS180_Human0.95288427
136* TCF4_23295773_ChIP-Seq_U87_Human0.94495461
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.93780004
138E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93120651
139AR_19668381_ChIP-Seq_PC3_Human0.92996888
140MAF_26560356_Chip-Seq_TH1_Human0.91676558
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91474845
142* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91174112
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91118515
144PU_27001747_Chip-Seq_BMDM_Mouse0.91076192
145* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90842416
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.90761545
147JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90725641
148* STAT3_23295773_ChIP-Seq_U87_Human0.90328673
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89963843
150AR_21572438_ChIP-Seq_LNCaP_Human0.89678838
151RACK7_27058665_Chip-Seq_MCF-7_Human0.88506586
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87838496
153SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87327490
154BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87048629
155REST_21632747_ChIP-Seq_MESCs_Mouse0.87013613
156ER_23166858_ChIP-Seq_MCF-7_Human0.86758884
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86209432
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85129703
159E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84721318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.15878930
2MP0003705_abnormal_hypodermis_morpholog3.49278064
3MP0008260_abnormal_autophagy3.38829356
4MP0003303_peritoneal_inflammation3.16286732
5MP0000537_abnormal_urethra_morphology2.90348553
6MP0008877_abnormal_DNA_methylation2.83349366
7MP0005623_abnormal_meninges_morphology2.77004752
8MP0010352_gastrointestinal_tract_polyps2.68738299
9MP0004130_abnormal_muscle_cell2.36297573
10MP0010234_abnormal_vibrissa_follicle2.31315331
11MP0000569_abnormal_digit_pigmentation2.28326639
12MP0005076_abnormal_cell_differentiation2.27851381
13MP0003172_abnormal_lysosome_physiology2.15724808
14MP0003183_abnormal_peptide_metabolism2.07187653
15MP0000733_abnormal_muscle_development2.05411509
16MP0003123_paternal_imprinting1.96228925
17MP0009053_abnormal_anal_canal1.94484704
18MP0005187_abnormal_penis_morphology1.94076033
19MP0008438_abnormal_cutaneous_collagen1.87549381
20MP0003119_abnormal_digestive_system1.87126652
21MP0003283_abnormal_digestive_organ1.85907191
22MP0003646_muscle_fatigue1.85068047
23MP0005409_darkened_coat_color1.84682235
24MP0004381_abnormal_hair_follicle1.82922062
25MP0003690_abnormal_glial_cell1.82147149
26MP0000428_abnormal_craniofacial_morphol1.80786157
27MP0004808_abnormal_hematopoietic_stem1.80235914
28MP0003045_fibrosis1.80166799
29MP0003385_abnormal_body_wall1.74107863
30MP0003763_abnormal_thymus_physiology1.73492011
31MP0002084_abnormal_developmental_patter1.72860034
32MP0004197_abnormal_fetal_growth/weight/1.72205781
33MP0000015_abnormal_ear_pigmentation1.71138579
34MP0004272_abnormal_basement_membrane1.70571085
35MP0002877_abnormal_melanocyte_morpholog1.70222067
36MP0003787_abnormal_imprinting1.69164978
37MP0000427_abnormal_hair_cycle1.67572486
38MP0001299_abnormal_eye_distance/1.66896691
39MP0002332_abnormal_exercise_endurance1.66145312
40MP0003937_abnormal_limbs/digits/tail_de1.64936351
41MP0003121_genomic_imprinting1.64444165
42MP0001545_abnormal_hematopoietic_system1.61837189
43MP0005397_hematopoietic_system_phenotyp1.61837189
44MP0003329_amyloid_beta_deposits1.60257144
45MP0002234_abnormal_pharynx_morphology1.58862311
46MP0000383_abnormal_hair_follicle1.56539902
47MP0003935_abnormal_craniofacial_develop1.53141758
48MP0003566_abnormal_cell_adhesion1.52310122
49MP0009278_abnormal_bone_marrow1.52272374
50MP0001348_abnormal_lacrimal_gland1.52079740
51MP0003567_abnormal_fetal_cardiomyocyte1.51749162
52MP0003115_abnormal_respiratory_system1.50141461
53MP0001730_embryonic_growth_arrest1.48657065
54MP0000778_abnormal_nervous_system1.46748417
55MP0005503_abnormal_tendon_morphology1.44786541
56MP0002697_abnormal_eye_size1.44728833
57MP0002085_abnormal_embryonic_tissue1.44137732
58MP0003091_abnormal_cell_migration1.42886204
59MP0003941_abnormal_skin_development1.40537992
60MP0001849_ear_inflammation1.39848629
61MP0002282_abnormal_trachea_morphology1.39336069
62MP0003890_abnormal_embryonic-extraembry1.39264283
63MP0000685_abnormal_immune_system1.38900260
64MP0005310_abnormal_salivary_gland1.38897289
65MP0002086_abnormal_extraembryonic_tissu1.36919879
66MP0005171_absent_coat_pigmentation1.35728439
67MP0005248_abnormal_Harderian_gland1.35431550
68MP0010030_abnormal_orbit_morphology1.35089501
69MP0001672_abnormal_embryogenesis/_devel1.34092909
70MP0005380_embryogenesis_phenotype1.34092909
71MP0002088_abnormal_embryonic_growth/wei1.32988267
72MP0008057_abnormal_DNA_replication1.32747081
73MP0003984_embryonic_growth_retardation1.32578347
74MP0003861_abnormal_nervous_system1.31104841
75MP0003755_abnormal_palate_morphology1.30939255
76MP0009780_abnormal_chondrocyte_physiolo1.30909904
77MP0004885_abnormal_endolymph1.30696325
78MP0002092_abnormal_eye_morphology1.28242548
79MP0003828_pulmonary_edema1.25000736
80MP0000432_abnormal_head_morphology1.22631741
81MP0001697_abnormal_embryo_size1.22578699
82MP0003453_abnormal_keratinocyte_physiol1.21909776
83MP0004233_abnormal_muscle_weight1.20817406
84MP0001293_anophthalmia1.20339216
85MP0002925_abnormal_cardiovascular_devel1.19895051
86MP0005275_abnormal_skin_tensile1.18720992
87MP0009703_decreased_birth_body1.17885165
88MP0004859_abnormal_synaptic_plasticity1.17293151
89MP0004484_altered_response_of1.16757943
90MP0003122_maternal_imprinting1.16390225
91MP0002116_abnormal_craniofacial_bone1.12807959
92MP0004084_abnormal_cardiac_muscle1.12766626
93MP0000579_abnormal_nail_morphology1.11427242
94MP0004134_abnormal_chest_morphology1.09402241
95MP0010678_abnormal_skin_adnexa1.08784330
96MP0002089_abnormal_postnatal_growth/wei1.08698134
97MP0001915_intracranial_hemorrhage1.07807689
98MP0005174_abnormal_tail_pigmentation1.06524614
99MP0004947_skin_inflammation1.06135896
100MP0004087_abnormal_muscle_fiber1.05477092
101MP0003942_abnormal_urinary_system1.05302538
102MP0006054_spinal_hemorrhage1.04998764
103MP0004811_abnormal_neuron_physiology1.04440518
104MP0003111_abnormal_nucleus_morphology1.03222116
105MP0002896_abnormal_bone_mineralization1.02993982
106MP0002932_abnormal_joint_morphology1.02775120
107MP0000762_abnormal_tongue_morphology1.02746026
108MP0004858_abnormal_nervous_system1.02129131
109MP0000350_abnormal_cell_proliferation1.02033122
110MP0005257_abnormal_intraocular_pressure1.01363694
111MP0000516_abnormal_urinary_system0.99103333
112MP0005367_renal/urinary_system_phenotyp0.99103333
113MP0005083_abnormal_biliary_tract0.98014635
114MP0000534_abnormal_ureter_morphology0.97177338
115MP0005508_abnormal_skeleton_morphology0.96500396
116MP0010307_abnormal_tumor_latency0.96195614
117MP0008961_abnormal_basal_metabolism0.94159164
118MP0009672_abnormal_birth_weight0.94128280
119MP0010630_abnormal_cardiac_muscle0.93408167
120MP0002080_prenatal_lethality0.93288603
121MP0002081_perinatal_lethality0.93266277
122MP0003436_decreased_susceptibility_to0.93151532
123MP0002822_catalepsy0.92716470
124MP0000003_abnormal_adipose_tissue0.92115007
125MP0009250_abnormal_appendicular_skeleto0.91810075
126MP0000462_abnormal_digestive_system0.91779259
127MP0002398_abnormal_bone_marrow0.91169452
128MP0002063_abnormal_learning/memory/cond0.90646533
129MP0000747_muscle_weakness0.90461492
130MP0001784_abnormal_fluid_regulation0.89840389
131MP0002396_abnormal_hematopoietic_system0.89431595
132MP0002111_abnormal_tail_morphology0.88905780
133MP0001286_abnormal_eye_development0.88371805
134MP0002233_abnormal_nose_morphology0.88265868
135MP0000377_abnormal_hair_follicle0.88233944
136MP0002009_preneoplasia0.87902110
137MP0000266_abnormal_heart_morphology0.87479418
138MP0005621_abnormal_cell_physiology0.86626310
139MP0002114_abnormal_axial_skeleton0.85885394
140MP0001958_emphysema0.85642685
141MP0000703_abnormal_thymus_morphology0.85065388
142MP0003634_abnormal_glial_cell0.84213414
143MP0003300_gastrointestinal_ulcer0.83890462
144MP0002419_abnormal_innate_immunity0.83452195
145MP0003635_abnormal_synaptic_transmissio0.82427487
146MP0004036_abnormal_muscle_relaxation0.82387350
147MP0005075_abnormal_melanosome_morpholog0.82372536
148MP0000467_abnormal_esophagus_morphology0.82220715
149MP0000163_abnormal_cartilage_morphology0.82086804
150MP0004510_myositis0.81979002
151MP0003632_abnormal_nervous_system0.81724453
152MP0000470_abnormal_stomach_morphology0.80752470
153MP0003221_abnormal_cardiomyocyte_apopto0.78187587
154MP0004264_abnormal_extraembryonic_tissu0.77528340
155MP0001188_hyperpigmentation0.75562709
156MP0000920_abnormal_myelination0.74714389
157* MP0005375_adipose_tissue_phenotype0.74505914
158MP0001216_abnormal_epidermal_layer0.74287992
159MP0006082_CNS_inflammation0.73961291
160MP0001851_eye_inflammation0.73726820
161MP0001800_abnormal_humoral_immune0.72772800
162MP0009931_abnormal_skin_appearance0.70652370
163MP0000955_abnormal_spinal_cord0.70401700
164MP0000371_diluted_coat_color0.70232960
165MP0004147_increased_porphyrin_level0.70096887
166MP0002405_respiratory_system_inflammati0.69419286
167MP0009115_abnormal_fat_cell0.68353114
168MP0004883_abnormal_blood_vessel0.67052452
169MP0002420_abnormal_adaptive_immunity0.66925528
170MP0002168_other_aberrant_phenotype0.64319272
171MP0003724_increased_susceptibility_to0.64208328
172MP0000604_amyloidosis0.63654814
173MP0002909_abnormal_adrenal_gland0.63630408
174MP0001835_abnormal_antigen_presentation0.63197497
175MP0003943_abnormal_hepatobiliary_system0.62478850
176MP0003631_nervous_system_phenotype0.62305659
177MP0001819_abnormal_immune_cell0.61598139

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.23287442
2Subacute progressive viral hepatitis (HP:0006572)3.65410942
3Shallow orbits (HP:0000586)3.38962581
4Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.18315314
5Papillary thyroid carcinoma (HP:0002895)3.12178492
6Dysmetric saccades (HP:0000641)3.00700929
7Hepatoblastoma (HP:0002884)2.98520810
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.84146890
9Short 4th metacarpal (HP:0010044)2.84146890
10Cerebral inclusion bodies (HP:0100314)2.80847497
11Hypoplastic ischia (HP:0003175)2.79944135
12Protruding tongue (HP:0010808)2.78366837
13Deep palmar crease (HP:0006191)2.75245115
14Abnormality of the heme biosynthetic pathway (HP:0010472)2.72228967
15Hypochromic microcytic anemia (HP:0004840)2.68924785
16Truncal obesity (HP:0001956)2.65621452
17Visual hallucinations (HP:0002367)2.61987656
18Genetic anticipation (HP:0003743)2.61529462
19Epiphyseal dysplasia (HP:0002656)2.59385169
20Poikilocytosis (HP:0004447)2.55113000
21Recurrent bacterial skin infections (HP:0005406)2.51232123
22Astrocytoma (HP:0009592)2.50104984
23Abnormality of the astrocytes (HP:0100707)2.50104984
24Exostoses (HP:0100777)2.47193311
25Difficulty climbing stairs (HP:0003551)2.43263903
26Abnormality of the 4th metacarpal (HP:0010012)2.40798727
27Urinary bladder sphincter dysfunction (HP:0002839)2.40412271
28Protrusio acetabuli (HP:0003179)2.39848067
29Widely spaced teeth (HP:0000687)2.36628580
30Pelvic girdle muscle weakness (HP:0003749)2.34857874
31Abnormality of the ischium (HP:0003174)2.34552123
32Macroorchidism (HP:0000053)2.31739067
33Mitral valve prolapse (HP:0001634)2.31504505
34Postural instability (HP:0002172)2.31100599
35Vertebral arch anomaly (HP:0008438)2.30687571
36Shoulder girdle muscle weakness (HP:0003547)2.29705897
37Gingivitis (HP:0000230)2.27900010
38Neurofibrillary tangles (HP:0002185)2.26586003
39Tapered finger (HP:0001182)2.25442510
40Genu recurvatum (HP:0002816)2.17796654
41Hypochromic anemia (HP:0001931)2.14726276
42Lymphangioma (HP:0100764)2.14154662
43Relative macrocephaly (HP:0004482)2.13986243
44Colon cancer (HP:0003003)2.12703927
45Malignant gastrointestinal tract tumors (HP:0006749)2.11909404
46Gastrointestinal carcinoma (HP:0002672)2.11909404
47Bundle branch block (HP:0011710)2.11477713
48Milia (HP:0001056)2.10939412
49Broad thumb (HP:0011304)2.09340836
50Termporal pattern (HP:0011008)2.08624398
51Insidious onset (HP:0003587)2.08624398
52Premature rupture of membranes (HP:0001788)2.08490063
53EMG: neuropathic changes (HP:0003445)2.08300112
54Febrile seizures (HP:0002373)2.05410539
55Ankle contracture (HP:0006466)2.04932726
56Submucous cleft hard palate (HP:0000176)2.04349917
57Metaphyseal cupping (HP:0003021)2.03759455
58Transitional cell carcinoma of the bladder (HP:0006740)2.03748539
59Bladder neoplasm (HP:0009725)2.02938950
60Bladder carcinoma (HP:0002862)2.02938950
61Vitreoretinal degeneration (HP:0000655)2.02768744
62Abnormality of the musculature of the pelvis (HP:0001469)2.01514847
63Abnormality of the hip-girdle musculature (HP:0001445)2.01514847
64Hyperacusis (HP:0010780)1.99969403
65Slow saccadic eye movements (HP:0000514)1.97504596
66Cerebral aneurysm (HP:0004944)1.97177702
67Leiomyosarcoma (HP:0100243)1.96933829
68Uterine leiomyosarcoma (HP:0002891)1.96933829
69Heterotopia (HP:0002282)1.96470867
70Buphthalmos (HP:0000557)1.96409133
71Eczematoid dermatitis (HP:0000976)1.93895117
72Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.93367282
73Ependymoma (HP:0002888)1.93216543
74Overgrowth (HP:0001548)1.92639712
75Neonatal hypoglycemia (HP:0001998)1.91959982
76Acute myeloid leukemia (HP:0004808)1.91921512
77Abnormality of the distal phalanx of the thumb (HP:0009617)1.91909270
78Thick eyebrow (HP:0000574)1.91540937
79Limb-girdle muscle weakness (HP:0003325)1.91529018
80Difficulty running (HP:0009046)1.91457042
81Fatigue (HP:0012378)1.90443002
82Germ cell neoplasia (HP:0100728)1.90302398
83Neoplasm of the adrenal cortex (HP:0100641)1.89957016
84Enlarged penis (HP:0000040)1.89225957
85Deep philtrum (HP:0002002)1.89209335
86Missing ribs (HP:0000921)1.88857192
87Volvulus (HP:0002580)1.88521364
88Onion bulb formation (HP:0003383)1.87365140
89Abnormality of the aortic arch (HP:0012303)1.87347656
90Obstructive sleep apnea (HP:0002870)1.87164144
91Scapular winging (HP:0003691)1.86933372
92Abnormal hair whorl (HP:0010721)1.86758445
93Cubitus valgus (HP:0002967)1.85648685
94Hypopigmentation of the fundus (HP:0007894)1.85152163
95Short 1st metacarpal (HP:0010034)1.84932782
96Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84932782
97Renal duplication (HP:0000075)1.84734354
98Abnormality of the fingertips (HP:0001211)1.84598997
99Osteomalacia (HP:0002749)1.83360654
100Increased connective tissue (HP:0009025)1.83226031
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82342006
102Hyperventilation (HP:0002883)1.82011129
103Abnormality of the pubic bones (HP:0003172)1.81141158
104Impaired vibratory sensation (HP:0002495)1.80229153
105Reticulocytosis (HP:0001923)1.79124106
106Bronchomalacia (HP:0002780)1.78692958
107Bowel diverticulosis (HP:0005222)1.77970564
108Progressive cerebellar ataxia (HP:0002073)1.77809080
109Hyporeflexia of lower limbs (HP:0002600)1.77498329
110Ankyloglossia (HP:0010296)1.77378834
111Deviation of the thumb (HP:0009603)1.77280492
112Sandal gap (HP:0001852)1.76982193
113T lymphocytopenia (HP:0005403)1.76831991
114Skull defect (HP:0001362)1.76121723
115Bladder diverticulum (HP:0000015)1.76001872
116Polycythemia (HP:0001901)1.75834967
117Micronodular cirrhosis (HP:0001413)1.75433950
118Thyroid carcinoma (HP:0002890)1.75402732
119Broad ribs (HP:0000885)1.75191530
120Glioma (HP:0009733)1.75076529
121Ulnar bowing (HP:0003031)1.75038347
122Long eyelashes (HP:0000527)1.74956596
123Abnormality of the corticospinal tract (HP:0002492)1.74255357
124Aortic aneurysm (HP:0004942)1.74085486
125Hip dysplasia (HP:0001385)1.73786104
126Megalocornea (HP:0000485)1.73538478
127Fibrous tissue neoplasm (HP:0012316)1.72098191
128Neoplasm of the tracheobronchial system (HP:0100552)1.71195959
129Fibroma (HP:0010614)1.71050227
130Microcytic anemia (HP:0001935)1.70396360
131Abnormality of nail color (HP:0100643)1.70356833
132Recurrent abscess formation (HP:0002722)1.70078184
133Dilatation of the ascending aorta (HP:0005111)1.69797126
134Neonatal short-limb short stature (HP:0008921)1.69397345
135Back pain (HP:0003418)1.68238490
136Mild short stature (HP:0003502)1.67422612
137Abnormality of the 1st metacarpal (HP:0010009)1.66535463
138Abnormality of T cell number (HP:0011839)1.66239198
139Short phalanx of the thumb (HP:0009660)1.66069459
140Peripheral hypomyelination (HP:0007182)1.65790300
141Elfin facies (HP:0004428)1.65362464
142Persistence of primary teeth (HP:0006335)1.65341633
143Renovascular hypertension (HP:0100817)1.65227693
144Hypoplasia of dental enamel (HP:0006297)1.64115539
145Spinal rigidity (HP:0003306)1.63416508
146Vertebral clefting (HP:0008428)1.63196648
147Broad phalanx (HP:0006009)1.62894429
148Broad long bones (HP:0005622)1.61583009
149Limited elbow extension (HP:0001377)1.61506590
150Wide anterior fontanel (HP:0000260)1.61447071
151Absent frontal sinuses (HP:0002688)1.61283244
152Broad phalanges of the hand (HP:0009768)1.61278072
153Stereotypic behavior (HP:0000733)1.60750793
154Thickened helices (HP:0000391)1.60281375
155Curly hair (HP:0002212)1.60219945
156Amyotrophic lateral sclerosis (HP:0007354)1.59764958
157Recurrent fungal infections (HP:0002841)1.59387012
158Open mouth (HP:0000194)1.59166193
159Abnormal vertebral ossification (HP:0100569)1.58486029
160Action tremor (HP:0002345)1.58206352
161Mildly elevated creatine phosphokinase (HP:0008180)1.58193839
162Deviation of the hallux (HP:0010051)1.57951651
163Hip contracture (HP:0003273)1.57612686
164Pointed chin (HP:0000307)1.57438115
165Hypoplastic labia majora (HP:0000059)1.57194794
166Abnormality of the calcaneus (HP:0008364)1.56495241
167Obsessive-compulsive behavior (HP:0000722)1.56484279
168Gastrointestinal infarctions (HP:0005244)1.55931491
169Achilles tendon contracture (HP:0001771)1.55897262
170Aplasia/Hypoplasia of the sternum (HP:0006714)1.55066612
171Hyperkalemia (HP:0002153)1.54613645
172Abnormality of the endocardium (HP:0004306)1.53863192
173Decreased motor nerve conduction velocity (HP:0003431)1.53731886
174Impaired vibration sensation in the lower limbs (HP:0002166)1.53565311
175Macroglossia (HP:0000158)1.52551036
176Ankle clonus (HP:0011448)1.52377478
177Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.51913524
178Abnormality of the phalanges of the hallux (HP:0010057)1.51421002
179Inappropriate behavior (HP:0000719)1.50697333
180Dislocated radial head (HP:0003083)1.50222138
181Abnormality of incisor morphology (HP:0011063)1.49575732
182Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.49164475
183Degeneration of the lateral corticospinal tracts (HP:0002314)1.49164475
184Low anterior hairline (HP:0000294)1.49089895
185Narrow palate (HP:0000189)1.48562484
186Toxemia of pregnancy (HP:0100603)1.48427963
187Menstrual irregularities (HP:0000858)1.47331477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.30899167
2PKN23.06926932
3AKT32.96296163
4TRIB32.86617531
5LATS12.69535160
6MAP3K102.65367937
7MAP2K32.46539179
8IRAK42.10194724
9DDR22.08727370
10SGK22.05506332
11PDGFRA2.05246060
12TTN2.05212148
13MARK12.01094494
14MAP3K111.99005022
15TAOK11.95905889
16RIPK11.82410552
17CAMK1G1.71953051
18PINK11.69589972
19PNCK1.65178309
20TYRO31.59769070
21SCYL21.57111214
22EPHB21.56603223
23LATS21.56520015
24PTK61.54025920
25MAP2K41.53023483
26EEF2K1.50739863
27BRD41.50533525
28CAMK1D1.44996208
29FGFR21.43551020
30NEK11.38307938
31MAP3K11.37862701
32PRKD31.37662992
33SGK2231.37296956
34SGK4941.37296956
35DMPK1.34861382
36CDC71.33861309
37MARK21.33417889
38CASK1.32903701
39STK31.32759214
40NEK21.30448446
41CSNK1A1L1.28990322
42ICK1.28797093
43CSNK1G21.27221298
44PRPF4B1.26605492
45CSNK1G11.26264491
46ALK1.23243749
47EPHB11.23203458
48MTOR1.22989118
49PTK2B1.20167067
50CSNK1G31.19966170
51STK38L1.19181022
52CDK61.16434173
53TRPM71.12896166
54SIK21.09336873
55MET1.07384467
56MAP3K61.05695788
57FGFR31.04522409
58PDGFRB1.03068457
59MAP3K141.01488169
60PAK60.99996383
61HIPK20.99511586
62BMX0.99312327
63FER0.97320955
64STK380.94290714
65MELK0.93556163
66DYRK1B0.93393202
67PTK20.92387995
68RET0.90886109
69PAK30.87879267
70BLK0.86698119
71MAP3K130.85328948
72IKBKE0.84823987
73RPS6KA20.83899699
74FGR0.83606476
75PAK20.82287125
76TTK0.81751245
77WNK10.81717514
78CSNK1D0.80036739
79SGK30.79842708
80* KSR10.77669352
81ERBB30.77040881
82FGFR10.75766976
83RIPK40.75520999
84EPHA20.75370637
85RPS6KL10.73975047
86RPS6KC10.73975047
87MAP3K40.73757787
88NTRK30.73738050
89IRAK10.72273220
90CHUK0.72238748
91PHKG10.72062816
92PHKG20.72062816
93FES0.71063112
94ILK0.69481826
95MKNK20.68619999
96ZAP700.68422000
97TAOK30.68377870
98RPS6KA60.67608106
99CAMK40.67579750
100JAK10.66384131
101PDK10.66341096
102MAP3K120.66131042
103PAK40.66111932
104WNK30.64303942
105MAP3K20.64179886
106CSK0.63912698
107ERBB20.63076295
108CHEK10.62963137
109BRAF0.62814310
110PLK30.62599803
111NEK90.62271863
112PRKD20.62206709
113PRKCH0.62153906
114STK40.61345714
115ROCK10.61116785
116MAP3K80.61115079
117MAP3K30.60528870
118ERN10.60056321
119GRK60.59932469
120FRK0.59639401
121GSK3A0.58576866
122CDK40.58502639
123MAP3K50.56496911
124MAPK100.55895713
125PDPK10.55793785
126CDK90.55610490
127MAP3K90.55274983
128PRKAA10.55256627
129JAK20.55068963
130CSNK1E0.55047793
131TAOK20.54488901
132PLK20.54037543
133MAP2K60.53976137
134IRAK30.53791864
135ROCK20.52136552
136WNK40.52118791
137EPHA30.51912423
138FGFR40.51892382
139CDK20.51737304
140CLK10.51284628
141STK240.51013763
142DYRK1A0.50896660
143RPS6KB10.50830010
144SYK0.49858891
145SGK10.49817405
146NLK0.49088139
147AKT20.48491963
148RAF10.48300468
149KSR20.48027911
150MKNK10.47838582
151LMTK20.47737072
152MAP3K70.47392030
153* STK110.46913964
154CHEK20.46886161
155MST1R0.46794804
156PRKDC0.46560801
157RPS6KB20.46507673
158LRRK20.44758259
159NUAK10.44514399
160CDK10.44124500
161EPHA40.42673579
162TLK10.42624132
163ATM0.41583082
164SIK10.41063174
165TGFBR10.39156601

Predicted pathways (KEGG)

RankGene SetZ-score
1Hippo signaling pathway_Homo sapiens_hsa043902.00231314
2Adherens junction_Homo sapiens_hsa045201.94569785
3Basal cell carcinoma_Homo sapiens_hsa052171.94534275
4Focal adhesion_Homo sapiens_hsa045101.87728691
5ECM-receptor interaction_Homo sapiens_hsa045121.84575232
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77441309
7mTOR signaling pathway_Homo sapiens_hsa041501.77130512
8MicroRNAs in cancer_Homo sapiens_hsa052061.76633102
9Proteoglycans in cancer_Homo sapiens_hsa052051.69990788
10Endometrial cancer_Homo sapiens_hsa052131.68040452
11Acute myeloid leukemia_Homo sapiens_hsa052211.66414452
12Tight junction_Homo sapiens_hsa045301.64050167
13Hedgehog signaling pathway_Homo sapiens_hsa043401.62329763
14Renal cell carcinoma_Homo sapiens_hsa052111.58128854
15Axon guidance_Homo sapiens_hsa043601.58027410
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57689336
17Glioma_Homo sapiens_hsa052141.56808740
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55168557
19Prolactin signaling pathway_Homo sapiens_hsa049171.54074299
20Chronic myeloid leukemia_Homo sapiens_hsa052201.51126409
21B cell receptor signaling pathway_Homo sapiens_hsa046621.49372143
22Lysine degradation_Homo sapiens_hsa003101.46094524
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45774435
24Systemic lupus erythematosus_Homo sapiens_hsa053221.45002666
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.44757475
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40600204
27Colorectal cancer_Homo sapiens_hsa052101.40454681
28Osteoclast differentiation_Homo sapiens_hsa043801.38530330
29Small cell lung cancer_Homo sapiens_hsa052221.38136772
30mRNA surveillance pathway_Homo sapiens_hsa030151.37869068
31Wnt signaling pathway_Homo sapiens_hsa043101.32257428
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31588567
33Dorso-ventral axis formation_Homo sapiens_hsa043201.28919907
34Nitrogen metabolism_Homo sapiens_hsa009101.28293783
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27307759
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26957786
37Melanogenesis_Homo sapiens_hsa049161.26577081
38Alcoholism_Homo sapiens_hsa050341.26200703
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25730393
40TGF-beta signaling pathway_Homo sapiens_hsa043501.25196002
41T cell receptor signaling pathway_Homo sapiens_hsa046601.23798794
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22953236
43TNF signaling pathway_Homo sapiens_hsa046681.21450714
44Dilated cardiomyopathy_Homo sapiens_hsa054141.20452487
45Long-term potentiation_Homo sapiens_hsa047201.19615111
46Non-small cell lung cancer_Homo sapiens_hsa052231.19305571
47Prostate cancer_Homo sapiens_hsa052151.18666615
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.17147939
49Inositol phosphate metabolism_Homo sapiens_hsa005621.16591789
50Estrogen signaling pathway_Homo sapiens_hsa049151.14907892
51Notch signaling pathway_Homo sapiens_hsa043301.12091575
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08908832
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08564412
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.08144269
55ErbB signaling pathway_Homo sapiens_hsa040121.07904004
56Gap junction_Homo sapiens_hsa045401.07211345
57Bladder cancer_Homo sapiens_hsa052191.06841715
58Platelet activation_Homo sapiens_hsa046111.06169497
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05941305
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.05644705
61Chemokine signaling pathway_Homo sapiens_hsa040621.03991001
62Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03491664
63Hepatitis C_Homo sapiens_hsa051601.01414388
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01286891
65Insulin resistance_Homo sapiens_hsa049311.01136492
66AMPK signaling pathway_Homo sapiens_hsa041521.01014853
67Oocyte meiosis_Homo sapiens_hsa041141.00819825
68Viral carcinogenesis_Homo sapiens_hsa052031.00654866
69Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00356681
70Protein digestion and absorption_Homo sapiens_hsa049741.00085936
71Viral myocarditis_Homo sapiens_hsa054160.99021782
72Malaria_Homo sapiens_hsa051440.98754037
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98145438
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.96403459
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96023266
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95979343
77Rap1 signaling pathway_Homo sapiens_hsa040150.95693390
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94656697
79FoxO signaling pathway_Homo sapiens_hsa040680.94481983
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.94448397
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93269068
82Hepatitis B_Homo sapiens_hsa051610.92608768
83Type II diabetes mellitus_Homo sapiens_hsa049300.92564473
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.92373735
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91014498
86Pancreatic cancer_Homo sapiens_hsa052120.89828803
87Measles_Homo sapiens_hsa051620.89114441
88Oxytocin signaling pathway_Homo sapiens_hsa049210.88943867
89Pathways in cancer_Homo sapiens_hsa052000.87679945
90Toxoplasmosis_Homo sapiens_hsa051450.87518881
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86626188
92Cholinergic synapse_Homo sapiens_hsa047250.86213815
93Melanoma_Homo sapiens_hsa052180.85740053
94Insulin signaling pathway_Homo sapiens_hsa049100.85593878
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85481233
96Leishmaniasis_Homo sapiens_hsa051400.85395278
97VEGF signaling pathway_Homo sapiens_hsa043700.85017718
98RNA transport_Homo sapiens_hsa030130.84924811
99Cell cycle_Homo sapiens_hsa041100.84828503
100HTLV-I infection_Homo sapiens_hsa051660.82614310
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.81668726
102Amoebiasis_Homo sapiens_hsa051460.81246918
103Tuberculosis_Homo sapiens_hsa051520.81032482
104Glucagon signaling pathway_Homo sapiens_hsa049220.80837526
105Influenza A_Homo sapiens_hsa051640.80374197
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78830992
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78235911
108Choline metabolism in cancer_Homo sapiens_hsa052310.77465929
109Long-term depression_Homo sapiens_hsa047300.75357258
110Dopaminergic synapse_Homo sapiens_hsa047280.74360929
111Regulation of autophagy_Homo sapiens_hsa041400.74322835
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.73953053
113MAPK signaling pathway_Homo sapiens_hsa040100.73303441
114Apoptosis_Homo sapiens_hsa042100.73194882
115African trypanosomiasis_Homo sapiens_hsa051430.71675344
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69863448
117Gastric acid secretion_Homo sapiens_hsa049710.69560678
118GnRH signaling pathway_Homo sapiens_hsa049120.68875319
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68287931
120Thyroid cancer_Homo sapiens_hsa052160.67869772
121cAMP signaling pathway_Homo sapiens_hsa040240.67570822
122HIF-1 signaling pathway_Homo sapiens_hsa040660.67051923
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.66809878
124Glutamatergic synapse_Homo sapiens_hsa047240.65331533
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64672336
126Circadian entrainment_Homo sapiens_hsa047130.64262653
127Amphetamine addiction_Homo sapiens_hsa050310.64255030
128Thyroid hormone synthesis_Homo sapiens_hsa049180.62349958
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61667291
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60826872
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60671337
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60483766
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59600762
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57871262
135Selenocompound metabolism_Homo sapiens_hsa004500.57742915
136Endocytosis_Homo sapiens_hsa041440.57380057
137p53 signaling pathway_Homo sapiens_hsa041150.56001969
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54772828
139Renin secretion_Homo sapiens_hsa049240.54574080
140Ras signaling pathway_Homo sapiens_hsa040140.54163032

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