MARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.84844207
2DNA methylation involved in gamete generation (GO:0043046)5.68965959
3protein localization to kinetochore (GO:0034501)5.60006477
4synaptonemal complex assembly (GO:0007130)5.14187667
5synaptonemal complex organization (GO:0070193)5.03695861
6protein localization to chromosome, centromeric region (GO:0071459)4.99490210
7nuclear pore complex assembly (GO:0051292)4.91194376
8male meiosis (GO:0007140)4.89637445
9cilium or flagellum-dependent cell motility (GO:0001539)4.84057113
10mitotic sister chromatid cohesion (GO:0007064)4.69472088
11nuclear pore organization (GO:0006999)4.67718649
12ribosome assembly (GO:0042255)4.66333752
13meiotic nuclear division (GO:0007126)4.41545412
14DNA unwinding involved in DNA replication (GO:0006268)4.24419924
15chromosome organization involved in meiosis (GO:0070192)4.23596671
16regulation of histone H3-K9 methylation (GO:0051570)4.22546236
17establishment of integrated proviral latency (GO:0075713)4.16151647
18IMP biosynthetic process (GO:0006188)4.11346786
19male meiosis I (GO:0007141)4.10061797
20regulation of RNA export from nucleus (GO:0046831)4.09178641
21meiotic chromosome segregation (GO:0045132)4.07214933
22DNA replication-dependent nucleosome organization (GO:0034723)4.02984187
23DNA replication-dependent nucleosome assembly (GO:0006335)4.02984187
24spliceosomal tri-snRNP complex assembly (GO:0000244)4.02527556
25formation of translation preinitiation complex (GO:0001731)3.99134556
26DNA replication initiation (GO:0006270)3.92953462
27transcription from mitochondrial promoter (GO:0006390)3.88795147
28protein complex localization (GO:0031503)3.88623584
29histone exchange (GO:0043486)3.88305661
30gene silencing by RNA (GO:0031047)3.86642972
31mitotic chromosome condensation (GO:0007076)3.82297724
32regulation of centriole replication (GO:0046599)3.81619367
33cellular protein complex localization (GO:0034629)3.81074965
34chromatin remodeling at centromere (GO:0031055)3.78335547
35IMP metabolic process (GO:0046040)3.74331457
36ribosome biogenesis (GO:0042254)3.69334656
37acrosome assembly (GO:0001675)3.66311544
38DNA strand elongation involved in DNA replication (GO:0006271)3.64395726
39CENP-A containing nucleosome assembly (GO:0034080)3.64208593
40folic acid-containing compound biosynthetic process (GO:0009396)3.62040943
41meiosis I (GO:0007127)3.61430476
42DNA replication-independent nucleosome organization (GO:0034724)3.60759570
43DNA replication-independent nucleosome assembly (GO:0006336)3.60759570
44protein localization to chromosome (GO:0034502)3.60338160
45monoubiquitinated protein deubiquitination (GO:0035520)3.59749371
46nucleobase biosynthetic process (GO:0046112)3.57853431
47meiotic cell cycle process (GO:1903046)3.57558088
48mitotic metaphase plate congression (GO:0007080)3.56163351
49kinetochore organization (GO:0051383)3.55213923
50peptidyl-arginine omega-N-methylation (GO:0035247)3.54951532
51attachment of spindle microtubules to kinetochore (GO:0008608)3.53154422
52mitochondrial RNA metabolic process (GO:0000959)3.52421266
53sister chromatid segregation (GO:0000819)3.52418003
54regulation of translational fidelity (GO:0006450)3.49832352
55translesion synthesis (GO:0019985)3.49697724
56DNA strand elongation (GO:0022616)3.49461281
57mitotic nuclear envelope disassembly (GO:0007077)3.49452471
58regulation of translational termination (GO:0006449)3.48932061
59regulation of nucleobase-containing compound transport (GO:0032239)3.48915425
60telomere maintenance via semi-conservative replication (GO:0032201)3.48807454
61regulation of meiosis I (GO:0060631)3.48771736
62pore complex assembly (GO:0046931)3.48674394
63sister chromatid cohesion (GO:0007062)3.48347797
64regulation of histone H3-K27 methylation (GO:0061085)3.46500623
65regulation of centrosome cycle (GO:0046605)3.45630249
66mitotic sister chromatid segregation (GO:0000070)3.43301669
67positive regulation of translational initiation (GO:0045948)3.40868143
68purine nucleobase biosynthetic process (GO:0009113)3.40243595
69DNA replication checkpoint (GO:0000076)3.39813913
70microtubule depolymerization (GO:0007019)3.36961102
71spindle checkpoint (GO:0031577)3.34260030
72membrane disassembly (GO:0030397)3.33048649
73nuclear envelope disassembly (GO:0051081)3.33048649
74mitotic recombination (GO:0006312)3.30410027
75DNA alkylation (GO:0006305)3.28441837
76DNA methylation (GO:0006306)3.28441837
77metaphase plate congression (GO:0051310)3.28039442
78mitotic spindle checkpoint (GO:0071174)3.25868382
79negative regulation of mRNA processing (GO:0050686)3.23435601
80telomere maintenance via recombination (GO:0000722)3.23183717
81histone arginine methylation (GO:0034969)3.20959602
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19927519
83establishment of viral latency (GO:0019043)3.19276512
84ATP-dependent chromatin remodeling (GO:0043044)3.18463890
85nuclear envelope organization (GO:0006998)3.17993603
86maturation of SSU-rRNA (GO:0030490)3.17904817
87DNA topological change (GO:0006265)3.16410638
88negative regulation of mRNA metabolic process (GO:1903312)3.15994558
89positive regulation of histone methylation (GO:0031062)3.13296009
90negative regulation of RNA splicing (GO:0033119)3.12058812
91reciprocal meiotic recombination (GO:0007131)3.11720232
92reciprocal DNA recombination (GO:0035825)3.11720232
93gene silencing (GO:0016458)3.10879963
94sperm-egg recognition (GO:0035036)3.10873388
95regulation of centrosome duplication (GO:0010824)3.09801499
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09157249
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09157249
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.09157249
99negative regulation of sister chromatid segregation (GO:0033046)3.09157249
100ribonucleoprotein complex biogenesis (GO:0022613)3.08697057
101negative regulation of histone methylation (GO:0031061)3.06300791
102spermatid development (GO:0007286)3.04967448
103binding of sperm to zona pellucida (GO:0007339)3.04406100
104chromosome organization (GO:0051276)3.03944547
105resolution of meiotic recombination intermediates (GO:0000712)3.02775551
106chromatin assembly or disassembly (GO:0006333)3.02390443
107rRNA transcription (GO:0009303)3.01873235
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01298855
109synapsis (GO:0007129)3.00571532
110meiotic cell cycle (GO:0051321)3.00446006
111nucleotide-excision repair, DNA gap filling (GO:0006297)3.00188922
112L-serine metabolic process (GO:0006563)2.99772557
113regulation of spindle checkpoint (GO:0090231)2.99362365
114axonemal dynein complex assembly (GO:0070286)2.99339410
115regulation of DNA endoreduplication (GO:0032875)2.99310676
116non-recombinational repair (GO:0000726)2.99304725
117double-strand break repair via nonhomologous end joining (GO:0006303)2.99304725
118regulation of chromosome segregation (GO:0051983)2.98169465
119regulation of mitotic spindle checkpoint (GO:1903504)2.98010692
120regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98010692
121rRNA processing (GO:0006364)2.96441920
122negative regulation of chromosome segregation (GO:0051985)2.96302237
123regulation of spindle organization (GO:0090224)2.95058115
124histone H2A acetylation (GO:0043968)2.94742421
125telomere maintenance via telomere lengthening (GO:0010833)2.94639693
126DNA packaging (GO:0006323)2.94506108
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93863192
128proline biosynthetic process (GO:0006561)2.93758972
129DNA conformation change (GO:0071103)2.93583757
130chromosome condensation (GO:0030261)2.93552080
131epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93531002
132DNA duplex unwinding (GO:0032508)2.93363785
133mitotic spindle assembly checkpoint (GO:0007094)2.92891732
134spliceosomal snRNP assembly (GO:0000387)2.92275078
135DNA geometric change (GO:0032392)2.91990167
136DNA synthesis involved in DNA repair (GO:0000731)2.91890596
137* tRNA aminoacylation for protein translation (GO:0006418)2.90178050
138somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90042174
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.90042174
140sperm motility (GO:0030317)2.90020493
141cell-cell recognition (GO:0009988)2.89947771
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89837640
143regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88746130
144regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88746130
145spindle assembly checkpoint (GO:0071173)2.87164542
146positive regulation of chromosome segregation (GO:0051984)2.84033156
147* tRNA aminoacylation (GO:0043039)2.83899529
148* amino acid activation (GO:0043038)2.83899529
149termination of RNA polymerase II transcription (GO:0006369)2.80776685
150establishment of chromosome localization (GO:0051303)2.80196213
151peptidyl-arginine N-methylation (GO:0035246)2.79811305
152peptidyl-arginine methylation (GO:0018216)2.79811305
153rRNA metabolic process (GO:0016072)2.78523369
154regulation of transcription from RNA polymerase I promoter (GO:0006356)2.76045094
155regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76040552
156mRNA transport (GO:0051028)2.75230297
157regulation of mitotic sister chromatid separation (GO:0010965)2.74850737
158regulation of mitotic sister chromatid segregation (GO:0033047)2.74850737
159regulation of sister chromatid segregation (GO:0033045)2.74850737
160regulation of sister chromatid cohesion (GO:0007063)2.70712611
161pseudouridine synthesis (GO:0001522)2.66775189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.51629229
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.86415699
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.63809332
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.13531100
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02285647
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.98529269
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73010161
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57591883
9* AR_21909140_ChIP-Seq_LNCAP_Human2.47218753
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41134753
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.34541811
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32887269
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03898201
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01179327
15MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00596319
16E2F7_22180533_ChIP-Seq_HELA_Human10.8037512
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.98996125
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90788696
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89729437
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88767157
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87713395
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81459919
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78729458
24XRN2_22483619_ChIP-Seq_HELA_Human1.78172203
25VDR_23849224_ChIP-Seq_CD4+_Human1.76616294
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75808754
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.74521484
28* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73371240
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.70503027
30FOXP3_21729870_ChIP-Seq_TREG_Human1.69692070
31EZH2_22144423_ChIP-Seq_EOC_Human1.68060072
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65272096
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59636776
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.59046544
35MYC_22102868_ChIP-Seq_BL_Human1.56539159
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47310779
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46939602
38DCP1A_22483619_ChIP-Seq_HELA_Human1.45767753
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44162196
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40776109
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40659665
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39210555
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.37643385
44CIITA_25753668_ChIP-Seq_RAJI_Human1.35815042
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35648057
46GABP_19822575_ChIP-Seq_HepG2_Human1.35517921
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35302512
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32665191
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32077437
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31574739
51TFEB_21752829_ChIP-Seq_HELA_Human1.31144609
52KDM5A_27292631_Chip-Seq_BREAST_Human1.30129171
53* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28273709
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28113952
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.28033773
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27594317
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24562538
58* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24348693
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24085015
60MYC_18940864_ChIP-ChIP_HL60_Human1.22012137
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21555917
62ZNF263_19887448_ChIP-Seq_K562_Human1.20560493
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19099737
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17400452
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16598767
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15768829
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15264189
68TTF2_22483619_ChIP-Seq_HELA_Human1.14694237
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12470604
70* NOTCH1_21737748_ChIP-Seq_TLL_Human1.11593375
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.10698627
72* FLI1_27457419_Chip-Seq_LIVER_Mouse1.08448059
73ZNF274_21170338_ChIP-Seq_K562_Hela1.07666133
74CHD1_26751641_Chip-Seq_LNCaP_Human1.06995624
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05229038
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04227436
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03166254
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02923897
79* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99864787
80EWS_26573619_Chip-Seq_HEK293_Human0.98196661
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97653563
82MAF_26560356_Chip-Seq_TH1_Human0.95920821
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95702419
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93702318
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93162114
86ELK1_19687146_ChIP-ChIP_HELA_Human0.92679206
87* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91994941
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91586834
89VDR_21846776_ChIP-Seq_THP-1_Human0.91564265
90TP63_17297297_ChIP-ChIP_HaCaT_Human0.91383249
91PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91155661
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90439655
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89924464
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89400059
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88015459
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86447305
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85923432
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85916469
99SPI1_23547873_ChIP-Seq_NB4_Human0.85278634
100* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84751024
101STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84249991
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84196681
103* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83384173
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81139760
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80555561
106* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80354732
107MYB_26560356_Chip-Seq_TH2_Human0.80247150
108MYB_26560356_Chip-Seq_TH1_Human0.80229372
109SCL_19346495_ChIP-Seq_HPC-7_Human0.79591731
110* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79439246
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78915564
112* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78747480
113E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77640943
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.77527033
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.74154006
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.71547812
117* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69075947
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.67593892
119YY1_21170310_ChIP-Seq_MESCs_Mouse0.65468562
120FUS_26573619_Chip-Seq_HEK293_Human0.63773083
121UTX_26944678_Chip-Seq_JUKART_Human0.63457015
122* NFE2_27457419_Chip-Seq_LIVER_Mouse0.63049884
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.60904619
124* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.60448028
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.60010929
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.59435592
127* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56739636
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.56734214
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.55422651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.07265011
2MP0008877_abnormal_DNA_methylation5.14696571
3MP0010094_abnormal_chromosome_stability4.53318052
4MP0005410_abnormal_fertilization3.51252273
5MP0003111_abnormal_nucleus_morphology3.46535840
6MP0008058_abnormal_DNA_repair3.22307921
7MP0003077_abnormal_cell_cycle3.16875322
8MP0003693_abnormal_embryo_hatching3.09148439
9MP0001929_abnormal_gametogenesis2.90265198
10MP0002210_abnormal_sex_determination2.79684958
11MP0004957_abnormal_blastocyst_morpholog2.77617678
12MP0008007_abnormal_cellular_replicative2.60937645
13MP0003698_abnormal_male_reproductive2.56921434
14MP0003786_premature_aging2.44334064
15MP0001145_abnormal_male_reproductive2.41762843
16MP0002396_abnormal_hematopoietic_system2.27890322
17MP0010352_gastrointestinal_tract_polyps2.12344874
18MP0000653_abnormal_sex_gland2.04934271
19MP0008995_early_reproductive_senescence2.02148506
20MP0004808_abnormal_hematopoietic_stem1.99084061
21MP0001730_embryonic_growth_arrest1.87993744
22MP0005451_abnormal_body_composition1.86623105
23MP0009672_abnormal_birth_weight1.84790218
24MP0000350_abnormal_cell_proliferation1.73657172
25MP0006035_abnormal_mitochondrial_morpho1.68378278
26MP0003941_abnormal_skin_development1.66212312
27MP0003763_abnormal_thymus_physiology1.65541550
28MP0004233_abnormal_muscle_weight1.59945934
29MP0004859_abnormal_synaptic_plasticity1.59503703
30MP0010307_abnormal_tumor_latency1.58027311
31MP0008932_abnormal_embryonic_tissue1.56255138
32MP0002161_abnormal_fertility/fecundity1.46680170
33MP0002009_preneoplasia1.44871371
34MP0010234_abnormal_vibrissa_follicle1.43333757
35MP0003718_maternal_effect1.39963537
36MP0000313_abnormal_cell_death1.33523354
37MP0004185_abnormal_adipocyte_glucose1.31853910
38MP0002877_abnormal_melanocyte_morpholog1.31687795
39MP0000703_abnormal_thymus_morphology1.31311406
40MP0004264_abnormal_extraembryonic_tissu1.29785967
41MP0000490_abnormal_crypts_of1.27658451
42MP0003890_abnormal_embryonic-extraembry1.26172101
43MP0002796_impaired_skin_barrier1.25821616
44MP0000427_abnormal_hair_cycle1.24532219
45MP0000537_abnormal_urethra_morphology1.22073726
46MP0002019_abnormal_tumor_incidence1.18926390
47MP0002084_abnormal_developmental_patter1.18579156
48MP0003221_abnormal_cardiomyocyte_apopto1.18556895
49MP0003123_paternal_imprinting1.18276812
50MP0001697_abnormal_embryo_size1.17385551
51MP0005380_embryogenesis_phenotype1.17381279
52MP0001672_abnormal_embryogenesis/_devel1.17381279
53MP0004134_abnormal_chest_morphology1.14579229
54MP0002085_abnormal_embryonic_tissue1.13570426
55MP0002080_prenatal_lethality1.13116458
56MP0004197_abnormal_fetal_growth/weight/1.10981408
57MP0005501_abnormal_skin_physiology1.10629340
58MP0000358_abnormal_cell_content/1.09252657
59MP0002398_abnormal_bone_marrow1.07908285
60MP0003787_abnormal_imprinting1.03476705
61MP0006036_abnormal_mitochondrial_physio1.02365663
62MP0008260_abnormal_autophagy1.01154347
63MP0005671_abnormal_response_to1.00510669
64MP0003984_embryonic_growth_retardation0.99357488
65MP0005409_darkened_coat_color0.95203541
66MP0009697_abnormal_copulation0.94947952
67MP0004147_increased_porphyrin_level0.94249817
68MP0001293_anophthalmia0.92885246
69MP0006292_abnormal_olfactory_placode0.92567311
70MP0002088_abnormal_embryonic_growth/wei0.91082821
71MP0001873_stomach_inflammation0.90946574
72MP0003806_abnormal_nucleotide_metabolis0.90810535
73MP0003861_abnormal_nervous_system0.89902642
74MP0003315_abnormal_perineum_morphology0.89142460
75MP0004270_analgesia0.88191528
76MP0005076_abnormal_cell_differentiation0.86863034
77MP0001119_abnormal_female_reproductive0.85749106
78MP0002086_abnormal_extraembryonic_tissu0.83500181
79MP0003121_genomic_imprinting0.83387118
80MP0000569_abnormal_digit_pigmentation0.82704945
81MP0001346_abnormal_lacrimal_gland0.81869531
82MP0000689_abnormal_spleen_morphology0.80951093
83MP0000015_abnormal_ear_pigmentation0.80930222
84MP0004811_abnormal_neuron_physiology0.78279361
85MP0002722_abnormal_immune_system0.77666686
86MP0000627_abnormal_mammary_gland0.77227046
87MP0002697_abnormal_eye_size0.76866934
88MP0000778_abnormal_nervous_system0.75688908
89MP0002095_abnormal_skin_pigmentation0.75074773
90MP0002160_abnormal_reproductive_system0.73984891
91MP0003880_abnormal_central_pattern0.73407431
92MP0001849_ear_inflammation0.72630747
93MP0002089_abnormal_postnatal_growth/wei0.71986993
94MP0005423_abnormal_somatic_nervous0.71869889
95MP0002254_reproductive_system_inflammat0.71786230
96MP0009046_muscle_twitch0.71557317
97MP0001835_abnormal_antigen_presentation0.70566059
98MP0001915_intracranial_hemorrhage0.70337253
99MP0001727_abnormal_embryo_implantation0.70172809
100MP0001661_extended_life_span0.70050208
101MP0003566_abnormal_cell_adhesion0.69754056
102MP0000685_abnormal_immune_system0.69566054
103MP0003699_abnormal_female_reproductive0.69216958
104MP0001216_abnormal_epidermal_layer0.67941577
105MP0008569_lethality_at_weaning0.67562264
106MP0001486_abnormal_startle_reflex0.66695031
107MP0003453_abnormal_keratinocyte_physiol0.66232356
108MP0002166_altered_tumor_susceptibility0.65945005
109MP0002111_abnormal_tail_morphology0.65307087
110MP0004215_abnormal_myocardial_fiber0.64676575
111MP0003635_abnormal_synaptic_transmissio0.64396490
112MP0000377_abnormal_hair_follicle0.64305497
113MP0000747_muscle_weakness0.62788583
114MP0001881_abnormal_mammary_gland0.62047304
115MP0003937_abnormal_limbs/digits/tail_de0.61978777
116MP0005220_abnormal_exocrine_pancreas0.61838239
117MP0001800_abnormal_humoral_immune0.61747035
118MP0002098_abnormal_vibrissa_morphology0.61667398
119MP0003943_abnormal_hepatobiliary_system0.61534653
120MP0002429_abnormal_blood_cell0.60987710
121MP0002152_abnormal_brain_morphology0.60648765
122MP0000579_abnormal_nail_morphology0.59620052
123MP0009333_abnormal_splenocyte_physiolog0.59537179
124MP0005621_abnormal_cell_physiology0.57956617
125MP0001529_abnormal_vocalization0.57938386
126MP0005623_abnormal_meninges_morphology0.57647680
127MP0008770_decreased_survivor_rate0.57619462
128MP0003656_abnormal_erythrocyte_physiolo0.57193320
129MP0004885_abnormal_endolymph0.57084933
130MP0004381_abnormal_hair_follicle0.56746101
131MP0000716_abnormal_immune_system0.55859612
132MP0005174_abnormal_tail_pigmentation0.55759138
133MP0002420_abnormal_adaptive_immunity0.55463500
134MP0001819_abnormal_immune_cell0.55081734
135MP0002063_abnormal_learning/memory/cond0.54964932
136MP0002006_tumorigenesis0.54691646
137MP0000428_abnormal_craniofacial_morphol0.54320670
138MP0000383_abnormal_hair_follicle0.54161388
139MP0002075_abnormal_coat/hair_pigmentati0.53421096
140MP0005384_cellular_phenotype0.52598551
141MP0002114_abnormal_axial_skeleton0.52506267
142MP0003646_muscle_fatigue0.51200022
143MP0000955_abnormal_spinal_cord0.51018733
144MP0009703_decreased_birth_body0.50620341

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.52076553
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.48110599
3Absent/shortened dynein arms (HP:0200106)4.48110599
4Progressive muscle weakness (HP:0003323)4.04807842
5Microvesicular hepatic steatosis (HP:0001414)3.90786637
6Multiple enchondromatosis (HP:0005701)3.74540654
7Abnormal spermatogenesis (HP:0008669)3.72714343
811 pairs of ribs (HP:0000878)3.45456831
9Chromsome breakage (HP:0040012)3.44311822
10Amyotrophic lateral sclerosis (HP:0007354)3.41144725
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33655104
12Ragged-red muscle fibers (HP:0003200)3.31029295
13Azoospermia (HP:0000027)3.27079919
14Selective tooth agenesis (HP:0001592)3.22932941
15Progressive external ophthalmoplegia (HP:0000590)3.21112332
16Abnormal respiratory epithelium morphology (HP:0012253)3.13329284
17Abnormal respiratory motile cilium morphology (HP:0005938)3.13329284
18Abnormal respiratory motile cilium physiology (HP:0012261)3.08489020
19Volvulus (HP:0002580)3.06602773
20Rhinitis (HP:0012384)2.97686066
21Abnormality of chromosome stability (HP:0003220)2.94248474
22Fibular hypoplasia (HP:0003038)2.93494492
23Birth length less than 3rd percentile (HP:0003561)2.74272411
24Heterotopia (HP:0002282)2.71143887
25Abnormality of glycolysis (HP:0004366)2.70667588
26Colon cancer (HP:0003003)2.69133512
27IgM deficiency (HP:0002850)2.69039239
28Prominent nose (HP:0000448)2.68723004
29Nephroblastoma (Wilms tumor) (HP:0002667)2.62025455
30Ectopic kidney (HP:0000086)2.59085025
31Abnormality of the lower motor neuron (HP:0002366)2.57668648
32Abnormality of homocysteine metabolism (HP:0010919)2.52663884
33Homocystinuria (HP:0002156)2.52663884
34Supernumerary spleens (HP:0009799)2.50927362
35Medulloblastoma (HP:0002885)2.49127990
36Overlapping toe (HP:0001845)2.43363073
37Nasal polyposis (HP:0100582)2.42234531
38Increased serum pyruvate (HP:0003542)2.39793625
39Embryonal renal neoplasm (HP:0011794)2.39246186
40Sloping forehead (HP:0000340)2.38427427
41Septate vagina (HP:0001153)2.38390199
42Spastic diplegia (HP:0001264)2.32972519
43Duplicated collecting system (HP:0000081)2.31984700
44IgA deficiency (HP:0002720)2.28429960
45Abnormality of the preputium (HP:0100587)2.26605097
46Poikiloderma (HP:0001029)2.26441393
47Increased nuchal translucency (HP:0010880)2.24287648
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23139393
49Facial hemangioma (HP:0000329)2.22674794
50Proximal placement of thumb (HP:0009623)2.22654228
51Aplasia/Hypoplasia of the fibula (HP:0006492)2.22546407
52Abnormality of the labia minora (HP:0012880)2.22234453
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.20350291
54Abnormal ciliary motility (HP:0012262)2.20047986
55Dysmetric saccades (HP:0000641)2.16972021
56Abnormal gallbladder physiology (HP:0012438)2.16592404
57Cholecystitis (HP:0001082)2.16592404
58Abnormality of the heme biosynthetic pathway (HP:0010472)2.16296441
59Meckel diverticulum (HP:0002245)2.15785775
60Cortical dysplasia (HP:0002539)2.15045480
61Premature ovarian failure (HP:0008209)2.14895676
62Infertility (HP:0000789)2.14815694
63Microglossia (HP:0000171)2.14364456
64Impulsivity (HP:0100710)2.14002659
65Chronic bronchitis (HP:0004469)2.12339611
66Type I transferrin isoform profile (HP:0003642)2.11138357
67Aplastic anemia (HP:0001915)2.08687789
68Reduced antithrombin III activity (HP:0001976)2.08504595
69Abnormality of methionine metabolism (HP:0010901)2.08044520
70Abnormality of the carotid arteries (HP:0005344)2.07828816
71Long eyelashes (HP:0000527)2.06724100
72Sensory axonal neuropathy (HP:0003390)2.06716278
73Abnormality of DNA repair (HP:0003254)2.06625663
74Abnormality of the ileum (HP:0001549)2.06267919
75Prominent metopic ridge (HP:0005487)2.05768571
76Deviation of the thumb (HP:0009603)2.04687339
77Lymphoma (HP:0002665)2.04595381
78Abnormality of ocular smooth pursuit (HP:0000617)2.04406411
79T lymphocytopenia (HP:0005403)2.04099804
80Ridged nail (HP:0001807)2.03404313
81Gonadotropin excess (HP:0000837)2.02125174
82Neoplasm of the oral cavity (HP:0100649)2.01895440
83Trismus (HP:0000211)2.00793021
84Atrophy/Degeneration involving motor neurons (HP:0007373)1.98926849
85Impaired proprioception (HP:0010831)1.96359307
86Degeneration of anterior horn cells (HP:0002398)1.95640392
87Abnormality of the anterior horn cell (HP:0006802)1.95640392
88Lymphopenia (HP:0001888)1.95532380
89Rough bone trabeculation (HP:0100670)1.94949190
90Dislocated radial head (HP:0003083)1.94680130
91Bronchitis (HP:0012387)1.93763608
92Basal cell carcinoma (HP:0002671)1.92799636
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92643008
94Abnormal protein N-linked glycosylation (HP:0012347)1.92643008
95Abnormal protein glycosylation (HP:0012346)1.92643008
96Abnormal glycosylation (HP:0012345)1.92643008
97Pancytopenia (HP:0001876)1.92126973
98Abnormality of chromosome segregation (HP:0002916)1.92103484
99Abnormality of cells of the lymphoid lineage (HP:0012140)1.92039831
100Cafe-au-lait spot (HP:0000957)1.89876113
101Truncal obesity (HP:0001956)1.89098543
102Absent radius (HP:0003974)1.88679921
103Shoulder girdle muscle weakness (HP:0003547)1.87250930
104Cellular immunodeficiency (HP:0005374)1.86391417
105Small intestinal stenosis (HP:0012848)1.85777866
106Duodenal stenosis (HP:0100867)1.85777866
107Abnormality of the renal collecting system (HP:0004742)1.85451610
108Recurrent viral infections (HP:0004429)1.85387874
109Reticulocytopenia (HP:0001896)1.84707432
110Carpal bone hypoplasia (HP:0001498)1.83496032
111Acute myeloid leukemia (HP:0004808)1.82813987
112Horseshoe kidney (HP:0000085)1.81895121
113Gaze-evoked nystagmus (HP:0000640)1.81856210
114Nephronophthisis (HP:0000090)1.81533036
115Recurrent bronchitis (HP:0002837)1.81379605
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.80696584
117Entropion (HP:0000621)1.80576104
118Sandal gap (HP:0001852)1.80482933
119Progressive hearing impairment (HP:0001730)1.79033699
120Abnormality of the fingertips (HP:0001211)1.78874251
121Abnormality of the radial head (HP:0003995)1.78441348
122Abnormal number of erythroid precursors (HP:0012131)1.77355646
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77081100
124Absent epiphyses (HP:0010577)1.77081100
125Pelvic girdle muscle weakness (HP:0003749)1.76150998
126Patellar aplasia (HP:0006443)1.76034057
127Short 4th metacarpal (HP:0010044)1.74991199
128Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74991199
129Sparse lateral eyebrow (HP:0005338)1.74922553
130Agammaglobulinemia (HP:0004432)1.74755189
131Myelodysplasia (HP:0002863)1.74409353
132Urethral obstruction (HP:0000796)1.74150573
133Bronchiectasis (HP:0002110)1.73750383
134Aplasia involving forearm bones (HP:0009822)1.73071726
135Absent forearm bone (HP:0003953)1.73071726
136Large eyes (HP:0001090)1.73038273
137Squamous cell carcinoma (HP:0002860)1.71904322
138Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71715930
139Absent thumb (HP:0009777)1.71502699
140Obsessive-compulsive behavior (HP:0000722)1.71329118
141Choanal atresia (HP:0000453)1.70008633
142B lymphocytopenia (HP:0010976)1.69997219
143Increased serum lactate (HP:0002151)1.69565297
144Gastrointestinal stroma tumor (HP:0100723)1.69069900
145Ependymoma (HP:0002888)1.69004686
146Breast carcinoma (HP:0003002)1.68972559
147Embryonal neoplasm (HP:0002898)1.68885619
148Abnormality of the duodenum (HP:0002246)1.68513665
149Cleft eyelid (HP:0000625)1.68209504
150Abnormality of T cell number (HP:0011839)1.67190073
151Papillary thyroid carcinoma (HP:0002895)1.66352301
152Astrocytoma (HP:0009592)1.66313726
153Abnormality of the astrocytes (HP:0100707)1.66313726
154Rhabdomyosarcoma (HP:0002859)1.66235428
155Ankyloglossia (HP:0010296)1.65912727
156Secondary amenorrhea (HP:0000869)1.64962983
157Conjunctival telangiectasia (HP:0000524)1.64794541
158Hyperacusis (HP:0010780)1.64453072
159Cerebral hypomyelination (HP:0006808)1.64189884
160Missing ribs (HP:0000921)1.64184046
161Glossoptosis (HP:0000162)1.64166350
162Combined immunodeficiency (HP:0005387)1.63094797
163Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62821097
164Abnormal foot bone ossification (HP:0010675)1.62527387
165Cutaneous melanoma (HP:0012056)1.61884069
166Abnormality of the umbilical cord (HP:0010881)1.61762258
167Bone marrow hypocellularity (HP:0005528)1.61193464
168Aplasia/Hypoplasia of the thymus (HP:0010515)1.60969654
169Long palpebral fissure (HP:0000637)1.59382570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.37450975
2PDK33.98876838
3PDK43.98876838
4SMG13.65498050
5WEE13.31180933
6ACVR1B3.24610408
7BUB12.85942728
8VRK22.76928887
9CDK122.73062273
10NEK22.65009666
11DYRK32.52068688
12CCNB12.44738273
13TAF12.25307409
14ATR2.18719454
15EEF2K2.15200474
16PRPF4B2.07371971
17NME22.05506426
18MKNK21.98734774
19BRD41.94913387
20VRK11.85115838
21PDK21.68923239
22CHEK21.62577823
23PBK1.62467636
24CHEK11.62144550
25PLK11.53471654
26MKNK11.49635934
27BRSK21.48138889
28TTK1.45535389
29PNCK1.40661934
30SRPK11.32358852
31STK101.31908914
32CDK71.27694711
33EIF2AK11.23009490
34CDK61.21498975
35STK161.20390004
36SCYL21.17996365
37ATM1.17908998
38MARK11.17131983
39MAP3K141.15761974
40AURKB1.15220563
41STK41.08848976
42PLK41.07266876
43TESK11.06164405
44NEK11.05703467
45TLK11.03946619
46TSSK61.03693192
47PLK31.03505625
48IRAK31.03028986
49BRSK11.02921830
50TRIB31.02787778
51MAP4K11.02713111
52ERBB40.98104280
53MST40.95450597
54KDR0.94400701
55SIK20.93397715
56PRKD30.90133337
57CLK10.89996639
58CDK20.87121083
59EIF2AK20.85142526
60CDK40.83440228
61MUSK0.82540624
62MARK30.80681515
63MAP3K100.80546077
64CDK10.79957889
65PAK40.79379609
66PIM20.79151133
67ALK0.75855893
68FGFR40.73741477
69CSNK1D0.73737163
70PRKDC0.73109003
71ICK0.72529117
72CSF1R0.70907108
73MAP3K40.66615832
74CDK90.66553546
75TESK20.64690059
76EIF2AK30.64470521
77SIK10.63600573
78MELK0.62700373
79CDK190.61349232
80KSR10.61088247
81STK390.60098023
82TRIM280.58701992
83PDK10.57316453
84CAMK1D0.56065683
85RPS6KA40.54880340
86MAP3K90.53981239
87MAP3K130.53025421
88AURKA0.52891956
89CSNK2A20.52073552
90MAP3K80.51861895
91RPS6KB20.50563572
92TYRO30.50012524
93TAOK20.48360553
94CAMK1G0.48249046
95MAPKAPK50.47812827
96NTRK30.46994495
97MTOR0.46743692
98RPS6KA50.45231134
99MAPK130.44489891
100AKT20.44416747
101PIM10.43915824
102RPS6KB10.43129320
103EPHA20.43119785
104NUAK10.42856335
105STK30.42766947
106NME10.42623223
107RAF10.42416660
108STK110.41101688
109ZAK0.41017349
110MAPK110.40709270
111PASK0.39266222
112GSK3B0.37933344
113MAPK100.36521645
114SIK30.36178162
115PKN20.35772102
116PDGFRB0.35522933
117TEC0.35136222
118MAP3K50.35041403
119MAPK140.34533543
120MARK20.34011992
121PTK2B0.33669819
122CDK30.33343236
123DYRK1A0.33308741
124TNIK0.32918440
125CDK180.32858945
126CDK150.32686179
127CDK11A0.32621287
128LIMK10.31735990
129MAPK80.31090624
130MINK10.31048977
131DAPK10.30457849
132CSNK2A10.30456973
133NEK60.30264516
134CDK140.29797977
135KIT0.28099454
136MAP2K70.27383714
137YES10.27282677
138PRKCI0.27042423
139CSNK1E0.26481536
140FLT30.20989029

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29034740
2Mismatch repair_Homo sapiens_hsa034303.79210211
3Non-homologous end-joining_Homo sapiens_hsa034503.64487824
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51868870
5Cell cycle_Homo sapiens_hsa041103.00749158
6Fanconi anemia pathway_Homo sapiens_hsa034602.91547640
7Homologous recombination_Homo sapiens_hsa034402.80672195
8RNA transport_Homo sapiens_hsa030132.71530356
9Basal transcription factors_Homo sapiens_hsa030222.69064479
10Spliceosome_Homo sapiens_hsa030402.62161063
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.45761636
12RNA polymerase_Homo sapiens_hsa030202.32292128
13Base excision repair_Homo sapiens_hsa034102.17815778
14Nucleotide excision repair_Homo sapiens_hsa034202.17058712
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15605283
16mRNA surveillance pathway_Homo sapiens_hsa030152.13792037
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01945699
18* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85050007
19Oocyte meiosis_Homo sapiens_hsa041141.81838018
20RNA degradation_Homo sapiens_hsa030181.76796527
21Pyrimidine metabolism_Homo sapiens_hsa002401.54898939
22Systemic lupus erythematosus_Homo sapiens_hsa053221.54380620
23Carbon metabolism_Homo sapiens_hsa012001.45002420
24p53 signaling pathway_Homo sapiens_hsa041151.37896658
25One carbon pool by folate_Homo sapiens_hsa006701.25256312
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18834767
27Vitamin B6 metabolism_Homo sapiens_hsa007501.18417764
28Alcoholism_Homo sapiens_hsa050341.15285241
29Primary immunodeficiency_Homo sapiens_hsa053401.13962844
30Pyruvate metabolism_Homo sapiens_hsa006201.10734495
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10382732
32Purine metabolism_Homo sapiens_hsa002301.08898545
33Viral carcinogenesis_Homo sapiens_hsa052031.07720163
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04248506
35Pentose phosphate pathway_Homo sapiens_hsa000301.01719233
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98166954
37Epstein-Barr virus infection_Homo sapiens_hsa051690.97327272
38Fructose and mannose metabolism_Homo sapiens_hsa000510.96795919
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96047556
40Long-term potentiation_Homo sapiens_hsa047200.92647983
41T cell receptor signaling pathway_Homo sapiens_hsa046600.91243030
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87927828
43B cell receptor signaling pathway_Homo sapiens_hsa046620.87722867
44Herpes simplex infection_Homo sapiens_hsa051680.87503972
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86831943
46HTLV-I infection_Homo sapiens_hsa051660.85333764
47Dorso-ventral axis formation_Homo sapiens_hsa043200.83238444
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83014881
49Sulfur relay system_Homo sapiens_hsa041220.80555017
50Colorectal cancer_Homo sapiens_hsa052100.80502737
51* Selenocompound metabolism_Homo sapiens_hsa004500.78640446
52MicroRNAs in cancer_Homo sapiens_hsa052060.78491518
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77765751
54Antigen processing and presentation_Homo sapiens_hsa046120.76950234
55Steroid biosynthesis_Homo sapiens_hsa001000.76522523
56Apoptosis_Homo sapiens_hsa042100.70694273
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70377369
58Fatty acid elongation_Homo sapiens_hsa000620.68916448
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68900498
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64689187
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64647500
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63905526
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63303765
64Wnt signaling pathway_Homo sapiens_hsa043100.60328526
65Bladder cancer_Homo sapiens_hsa052190.58244145
66ErbB signaling pathway_Homo sapiens_hsa040120.57835267
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56263071
68Amphetamine addiction_Homo sapiens_hsa050310.55694257
69N-Glycan biosynthesis_Homo sapiens_hsa005100.55476058
70VEGF signaling pathway_Homo sapiens_hsa043700.55358561
71mTOR signaling pathway_Homo sapiens_hsa041500.55045192
72Ribosome_Homo sapiens_hsa030100.54348700
73Prostate cancer_Homo sapiens_hsa052150.52635609
74Glioma_Homo sapiens_hsa052140.51858816
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51788843
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.49681754
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49591939
78Inositol phosphate metabolism_Homo sapiens_hsa005620.49548473
79Influenza A_Homo sapiens_hsa051640.47432077
80Chronic myeloid leukemia_Homo sapiens_hsa052200.47395811
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46971775
82Lysine degradation_Homo sapiens_hsa003100.45745039
83Non-small cell lung cancer_Homo sapiens_hsa052230.44771187
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.44021258
85Hepatitis B_Homo sapiens_hsa051610.43496804
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.42897954
87Glucagon signaling pathway_Homo sapiens_hsa049220.42354404
88Small cell lung cancer_Homo sapiens_hsa052220.41802794
89Pancreatic cancer_Homo sapiens_hsa052120.41660652
90Salivary secretion_Homo sapiens_hsa049700.41218387
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40677691
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39962417
93Legionellosis_Homo sapiens_hsa051340.39782829
94Notch signaling pathway_Homo sapiens_hsa043300.39622570
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39200763
96Fatty acid metabolism_Homo sapiens_hsa012120.38064378
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37916056
98Nicotine addiction_Homo sapiens_hsa050330.37914676
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37852052
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37577347
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37175416
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35746114
103Proteasome_Homo sapiens_hsa030500.35288978
104Gastric acid secretion_Homo sapiens_hsa049710.35261651
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34341516
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34046310
107Glutamatergic synapse_Homo sapiens_hsa047240.33822771
108Galactose metabolism_Homo sapiens_hsa000520.32881055
109Calcium signaling pathway_Homo sapiens_hsa040200.32544525
110Endometrial cancer_Homo sapiens_hsa052130.32486495
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.32405569
112Propanoate metabolism_Homo sapiens_hsa006400.32387502
113Gap junction_Homo sapiens_hsa045400.32215893
114Estrogen signaling pathway_Homo sapiens_hsa049150.32203971
115Thyroid cancer_Homo sapiens_hsa052160.31667289
116Arginine and proline metabolism_Homo sapiens_hsa003300.31236067
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31189597
118Shigellosis_Homo sapiens_hsa051310.30988374
119Dopaminergic synapse_Homo sapiens_hsa047280.30139299
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29880726
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.28840430
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.28434119
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28370481
124Viral myocarditis_Homo sapiens_hsa054160.28060728
125Measles_Homo sapiens_hsa051620.27822359
126Circadian entrainment_Homo sapiens_hsa047130.27335763
127Acute myeloid leukemia_Homo sapiens_hsa052210.26505447
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26163747
129Biosynthesis of amino acids_Homo sapiens_hsa012300.26102160
130Choline metabolism in cancer_Homo sapiens_hsa052310.26058753
131Morphine addiction_Homo sapiens_hsa050320.25729250
132FoxO signaling pathway_Homo sapiens_hsa040680.25476958
133MAPK signaling pathway_Homo sapiens_hsa040100.25261056
134Huntingtons disease_Homo sapiens_hsa050160.24892050
135Folate biosynthesis_Homo sapiens_hsa007900.24556352
136Hepatitis C_Homo sapiens_hsa051600.24050238
137Metabolic pathways_Homo sapiens_hsa011000.21518166
138Protein export_Homo sapiens_hsa030600.21393866
139Phenylalanine metabolism_Homo sapiens_hsa003600.20652830
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18408135
141Adherens junction_Homo sapiens_hsa045200.15219273

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