MARVELD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.63991942
2COPI coating of Golgi vesicle (GO:0048205)8.63991942
3endocrine pancreas development (GO:0031018)6.62725370
4intestinal epithelial cell development (GO:0060576)6.27943951
5signal peptide processing (GO:0006465)6.17275891
6glandular epithelial cell differentiation (GO:0002067)5.96770686
7behavioral response to nicotine (GO:0035095)5.32423932
8exocrine pancreas development (GO:0031017)5.20829179
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.11787609
10peptide hormone processing (GO:0016486)5.03500518
11pyrimidine nucleoside salvage (GO:0043097)4.94342749
12pyrimidine-containing compound salvage (GO:0008655)4.94342749
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.86036298
14intestinal absorption (GO:0050892)4.80408136
15insulin secretion (GO:0030073)4.63691812
16COPII vesicle coating (GO:0048208)4.59989612
17intestinal cholesterol absorption (GO:0030299)4.57742279
18water-soluble vitamin biosynthetic process (GO:0042364)4.54537066
19sulfation (GO:0051923)4.47491639
20flavonoid metabolic process (GO:0009812)4.44943090
21columnar/cuboidal epithelial cell development (GO:0002066)4.37590052
22regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.29904835
23regulation of type B pancreatic cell apoptotic process (GO:2000674)4.27648868
24protein retention in ER lumen (GO:0006621)4.18502564
25regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.10347350
26sulfate transmembrane transport (GO:1902358)4.04520950
27fucose catabolic process (GO:0019317)4.01553781
28L-fucose metabolic process (GO:0042354)4.01553781
29L-fucose catabolic process (GO:0042355)4.01553781
30positive regulation of insulin secretion (GO:0032024)3.86853151
31vesicle coating (GO:0006901)3.81392018
32DNA deamination (GO:0045006)3.80806544
33angiotensin maturation (GO:0002003)3.78388678
34type B pancreatic cell development (GO:0003323)3.78174773
35purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.76104210
363-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.76104210
37regulation of gene silencing by RNA (GO:0060966)3.74329044
38regulation of posttranscriptional gene silencing (GO:0060147)3.74329044
39regulation of gene silencing by miRNA (GO:0060964)3.74329044
40nucleotide-sugar metabolic process (GO:0009225)3.68736526
41viral entry into host cell (GO:0046718)3.61947903
42kidney morphogenesis (GO:0060993)3.61160873
43nucleoside salvage (GO:0043174)3.59771768
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.58618090
45auditory receptor cell differentiation (GO:0042491)3.58154430
46sulfate transport (GO:0008272)3.57012829
47UDP-N-acetylglucosamine metabolic process (GO:0006047)3.55546357
48protein maturation by protein folding (GO:0022417)3.54084679
49indole-containing compound catabolic process (GO:0042436)3.43999750
50indolalkylamine catabolic process (GO:0046218)3.43999750
51tryptophan catabolic process (GO:0006569)3.43999750
52indolalkylamine metabolic process (GO:0006586)3.42291800
53membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.41911211
54calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.40280826
55bundle of His cell to Purkinje myocyte communication (GO:0086069)3.39342704
56DNA methylation involved in gamete generation (GO:0043046)3.38214414
57pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.38048172
58UMP biosynthetic process (GO:0006222)3.38048172
59pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.38048172
60UMP metabolic process (GO:0046049)3.38048172
61positive regulation of nuclease activity (GO:0032075)3.37388771
62peptide hormone secretion (GO:0030072)3.37354796
63regulation of guanylate cyclase activity (GO:0031282)3.36891951
64cellular response to vitamin D (GO:0071305)3.36216960
65piRNA metabolic process (GO:0034587)3.35443361
66positive regulation of fatty acid oxidation (GO:0046321)3.34991431
67cellular response to glucose starvation (GO:0042149)3.34325881
68peptide secretion (GO:0002790)3.33454877
69GDP-mannose metabolic process (GO:0019673)3.30723379
70nucleotide salvage (GO:0043173)3.27249447
71glandular epithelial cell development (GO:0002068)3.27151724
72digestion (GO:0007586)3.24756865
73peptide catabolic process (GO:0043171)3.23893533
74diol metabolic process (GO:0034311)3.23882351
75sphingoid metabolic process (GO:0046519)3.21214546
76drug catabolic process (GO:0042737)3.20647585
77exogenous drug catabolic process (GO:0042738)3.17901218
78regulation of insulin secretion (GO:0050796)3.16387049
79pentose metabolic process (GO:0019321)3.15165095
80positive regulation of peptide hormone secretion (GO:0090277)3.13334029
81kynurenine metabolic process (GO:0070189)3.09624462
82adhesion of symbiont to host cell (GO:0044650)3.08896508
83virion attachment to host cell (GO:0019062)3.08896508
84positive regulation of fatty acid beta-oxidation (GO:0032000)3.08571437
85endoplasmic reticulum unfolded protein response (GO:0030968)3.08278287
86heme transport (GO:0015886)3.08160788
87sequestering of metal ion (GO:0051238)3.06088486
88membrane repolarization during action potential (GO:0086011)3.05945972
89neuron fate specification (GO:0048665)3.04611557
90regulation of nuclease activity (GO:0032069)3.04440323
91regulation of mesoderm development (GO:2000380)3.02940297
92uronic acid metabolic process (GO:0006063)3.02380188
93glucuronate metabolic process (GO:0019585)3.02380188
94cellular response to unfolded protein (GO:0034620)3.02085865
95Golgi organization (GO:0007030)3.00833954
96peptide transport (GO:0015833)3.00245532
97glycerol metabolic process (GO:0006071)3.00127672
98L-phenylalanine catabolic process (GO:0006559)2.98529083
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.98529083
100cellular glucuronidation (GO:0052695)2.97946501
101positive regulation of peptide secretion (GO:0002793)2.97567781
102vitamin biosynthetic process (GO:0009110)2.96604975
103serotonin metabolic process (GO:0042428)2.96354929
104sulfur compound transport (GO:0072348)2.96073154
105regulation of hexokinase activity (GO:1903299)2.95615223
106regulation of glucokinase activity (GO:0033131)2.95615223
107pyrimidine nucleoside catabolic process (GO:0046135)2.95334543
108primary amino compound metabolic process (GO:1901160)2.95019111
109mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94249662
110ATP synthesis coupled proton transport (GO:0015986)2.92278117
111energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92278117
112sphingosine metabolic process (GO:0006670)2.92161636
113regulation of hippo signaling (GO:0035330)2.91321494
114activation of protein kinase A activity (GO:0034199)2.90872233
115regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.90858359
116endocrine process (GO:0050886)2.90858359
117regulation of systemic arterial blood pressure by hormone (GO:0001990)2.90858359
118protein autoprocessing (GO:0016540)2.90591959
119positive regulation of guanylate cyclase activity (GO:0031284)2.89883219
120regulation of peptide hormone secretion (GO:0090276)2.88300134
121regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.88041689
122positive regulation of gastrulation (GO:2000543)2.86517746
123cellular response to topologically incorrect protein (GO:0035967)2.86439026
124negative regulation of keratinocyte proliferation (GO:0010839)2.83468770
125arginine metabolic process (GO:0006525)2.82406046
126positive regulation of glycolytic process (GO:0045821)2.82289252
127protein complex biogenesis (GO:0070271)2.82097420
128L-phenylalanine metabolic process (GO:0006558)2.81411341
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.81411341
130signal transduction involved in regulation of gene expression (GO:0023019)2.80966908
131regulation of peptide secretion (GO:0002791)2.80932115
132ER-nucleus signaling pathway (GO:0006984)2.79983306
133positive regulation of hormone biosynthetic process (GO:0046886)2.79904307
134primitive streak formation (GO:0090009)2.79769740
135iron coordination entity transport (GO:1901678)2.79283111
136phenol-containing compound catabolic process (GO:0019336)2.78970425
137indole-containing compound metabolic process (GO:0042430)2.78638080
138response to endoplasmic reticulum stress (GO:0034976)2.78511529
139ER overload response (GO:0006983)2.77413373
140cytidine metabolic process (GO:0046087)2.77034783
141cytidine catabolic process (GO:0006216)2.77034783
142cytidine deamination (GO:0009972)2.77034783
143digestive system process (GO:0022600)2.76207701
144negative regulation of glycoprotein biosynthetic process (GO:0010561)2.76048476
1454-hydroxyproline metabolic process (GO:0019471)2.75134317
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74850314
147response to pheromone (GO:0019236)2.72510913
148cellular response to ATP (GO:0071318)2.71841245
149respiratory chain complex IV assembly (GO:0008535)2.71377301
150regulation of cardioblast proliferation (GO:0003264)2.71243155
151regulation of secondary heart field cardioblast proliferation (GO:0003266)2.71243155
152hemidesmosome assembly (GO:0031581)2.71187006
153alditol metabolic process (GO:0019400)2.67955957
154tryptophan metabolic process (GO:0006568)2.67640552
155regulation of triglyceride catabolic process (GO:0010896)2.67620901
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.66705019
157cytochrome complex assembly (GO:0017004)2.66666918
158vitamin transmembrane transport (GO:0035461)2.66495198
159mitochondrial respiratory chain complex assembly (GO:0033108)2.65225440
160drug metabolic process (GO:0017144)2.63376357
161platelet dense granule organization (GO:0060155)2.62686000
162regulation of meiosis I (GO:0060631)2.62153849
163aromatic amino acid family catabolic process (GO:0009074)2.61036693
164regulation of rhodopsin mediated signaling pathway (GO:0022400)2.60644407
165positive regulation of fatty acid transport (GO:2000193)2.59217136
166mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57090196
167negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55942124
168transepithelial transport (GO:0070633)2.55549000
169rhodopsin mediated signaling pathway (GO:0016056)2.54934274
170epoxygenase P450 pathway (GO:0019373)2.50833175
171serotonin receptor signaling pathway (GO:0007210)2.49058814
172somite development (GO:0061053)2.48212622
173cellular ketone body metabolic process (GO:0046950)2.48035837
174neuronal action potential (GO:0019228)2.47505831
175reflex (GO:0060004)2.47282756
176epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45606101
177gamma-aminobutyric acid transport (GO:0015812)2.45538476
178thyroid hormone metabolic process (GO:0042403)2.45411215
179mitochondrial respiratory chain complex I assembly (GO:0032981)2.44454773
180NADH dehydrogenase complex assembly (GO:0010257)2.44454773
181mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44454773
182nephron epithelium morphogenesis (GO:0072088)2.44211150
183nephron tubule morphogenesis (GO:0072078)2.44211150
184positive regulation of respiratory burst (GO:0060267)2.43495433
185epithelial cilium movement (GO:0003351)2.43472006
186protein polyglutamylation (GO:0018095)2.43042702
187neurotransmitter metabolic process (GO:0042133)2.42278802
188negative regulation of T cell differentiation in thymus (GO:0033085)2.41295944
189negative regulation of telomere maintenance (GO:0032205)2.40921867
190male meiosis I (GO:0007141)2.39585198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.74440988
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79585088
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.65094829
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.59155501
5ZNF274_21170338_ChIP-Seq_K562_Hela3.45121555
6VDR_22108803_ChIP-Seq_LS180_Human3.07942321
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.91291902
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.90489188
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.85264322
10GATA4_25053715_ChIP-Seq_YYC3_Human2.63490407
11SOX2_20726797_ChIP-Seq_SW620_Human2.59120960
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.51783510
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.46719221
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.41440528
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40447709
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.35035803
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.31180078
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30426571
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29100555
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.25824649
21GATA6_25053715_ChIP-Seq_YYC3_Human2.25740868
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21716234
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.19764615
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17046154
25FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.17006708
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.09325200
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01009272
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99029455
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.98598598
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.98487523
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97391489
32GBX2_23144817_ChIP-Seq_PC3_Human1.92605304
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92299166
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90652169
35P300_19829295_ChIP-Seq_ESCs_Human1.90421402
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86619145
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83255038
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.82970455
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82238692
40EZH2_22144423_ChIP-Seq_EOC_Human1.80951720
41ER_23166858_ChIP-Seq_MCF-7_Human1.80033376
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77969167
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77825481
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75764003
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74207689
46FUS_26573619_Chip-Seq_HEK293_Human1.71269930
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70852061
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.62023699
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.61639459
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.61639459
51* GATA3_24758297_ChIP-Seq_MCF-7_Human1.58788685
52FOXA1_25552417_ChIP-Seq_VCAP_Human1.58271053
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53749308
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53210040
55CLOCK_20551151_ChIP-Seq_293T_Human1.53113575
56EWS_26573619_Chip-Seq_HEK293_Human1.51682067
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51323239
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49129766
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.44807528
60* NCOR_22424771_ChIP-Seq_293T_Human1.42980960
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41580837
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40902036
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40678198
64RACK7_27058665_Chip-Seq_MCF-7_Human1.40476076
65KLF5_25053715_ChIP-Seq_YYC3_Human1.40033232
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39455317
67HOXB7_26014856_ChIP-Seq_BT474_Human1.38201776
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.37021980
69* SOX2_19829295_ChIP-Seq_ESCs_Human1.35585143
70* NANOG_19829295_ChIP-Seq_ESCs_Human1.35585143
71MYC_18940864_ChIP-ChIP_HL60_Human1.35446024
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35046872
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.33231347
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32907940
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.32886789
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32582602
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32550935
78CBP_20019798_ChIP-Seq_JUKART_Human1.32144750
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32144750
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30825363
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29822612
82TP53_22573176_ChIP-Seq_HFKS_Human1.29566143
83AR_20517297_ChIP-Seq_VCAP_Human1.29305627
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27572040
85FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.27467327
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27260320
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27260320
88FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27065335
89TCF4_22108803_ChIP-Seq_LS180_Human1.26650383
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26370554
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.25999755
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.25558835
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25530384
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25521758
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24520064
96TAF15_26573619_Chip-Seq_HEK293_Human1.23698682
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23377976
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22954762
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.22319685
100BCAT_22108803_ChIP-Seq_LS180_Human1.21643691
101AR_25329375_ChIP-Seq_VCAP_Human1.21573201
102TCF4_23295773_ChIP-Seq_U87_Human1.21396928
103TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21082713
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19369772
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19221984
106AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19015000
107ATF3_27146783_Chip-Seq_COLON_Human1.18215241
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.17718780
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17687605
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17638130
111STAT3_23295773_ChIP-Seq_U87_Human1.17192481
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16958035
113* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16806756
114IRF1_19129219_ChIP-ChIP_H3396_Human1.16632466
115REST_21632747_ChIP-Seq_MESCs_Mouse1.15030955
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.14644435
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14612045
118* EED_16625203_ChIP-ChIP_MESCs_Mouse1.14237336
119* NANOG_20526341_ChIP-Seq_ESCs_Human1.14196632
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14096154
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13012479
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.12988097
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.12408670
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11498579
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.10999147
126ERA_21632823_ChIP-Seq_H3396_Human1.09979945
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09766894
128CREB1_26743006_Chip-Seq_LNCaP_Human1.09554338
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07948877
130CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07775619
131* P53_21459846_ChIP-Seq_SAOS-2_Human1.07767365
132MYC_19829295_ChIP-Seq_ESCs_Human1.06960811
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06951512
134AR_21572438_ChIP-Seq_LNCaP_Human1.06477072
135CHD1_26751641_Chip-Seq_LNCaP_Human1.05602988
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05513947
137TAF2_19829295_ChIP-Seq_ESCs_Human1.03322617
138CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03245712
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02775147
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02745980
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01576696
142ELK1_22589737_ChIP-Seq_MCF10A_Human1.00824638
143* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00797283
144AHR_22903824_ChIP-Seq_MCF-7_Human1.00218780
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99899905
146PRDM14_20953172_ChIP-Seq_ESCs_Human0.99879068
147CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99572984
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.99259173
149RNF2_27304074_Chip-Seq_NSC_Mouse0.98247971
150SMAD4_21799915_ChIP-Seq_A2780_Human0.97630157
151* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96925209
152RXR_22108803_ChIP-Seq_LS180_Human0.96746588
153LXR_22292898_ChIP-Seq_THP-1_Human0.96647474
154CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96469065
155IGF1R_20145208_ChIP-Seq_DFB_Human0.96198599
156CDX2_22108803_ChIP-Seq_LS180_Human0.95717141
157HNF4A_19822575_ChIP-Seq_HepG2_Human0.93796710
158GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93659160
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93642536
160TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93043802
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86897837
162EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85503617
163SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80166007
164SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80166007
165TP63_22573176_ChIP-Seq_HFKS_Human0.79193094
166PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78877849
167TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78140750
168PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77625618
169TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.77295736
170ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76728115
171RARA_24833708_ChIP-Seq_LIVER_Mouse0.76595053
172ISL1_27105846_Chip-Seq_CPCs_Mouse0.75974820
173STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74861914
174GATA1_22025678_ChIP-Seq_K562_Human0.74817402
175ESR1_20079471_ChIP-ChIP_T-47D_Human0.74008799
176TP63_23658742_ChIP-Seq_EP156T_Human0.72659990
177NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72181645
178CJUN_26792858_Chip-Seq_BT549_Human0.71170301
179ZNF263_19887448_ChIP-Seq_K562_Human0.70736784
180NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70179086
181* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.70167087
182P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.68666125
183SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67742427
184BMI1_23680149_ChIP-Seq_NPCS_Mouse0.67681324
185FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.67260662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.70984819
2MP0003283_abnormal_digestive_organ4.37101243
3MP0003806_abnormal_nucleotide_metabolis3.83206589
4MP0003136_yellow_coat_color3.60601123
5MP0004264_abnormal_extraembryonic_tissu3.55234312
6MP0004043_abnormal_pH_regulation3.47479515
7MP0010386_abnormal_urinary_bladder2.96357100
8MP0003183_abnormal_peptide_metabolism2.96267258
9MP0001666_abnormal_nutrient_absorption2.94675367
10MP0005409_darkened_coat_color2.89052889
11MP0000462_abnormal_digestive_system2.71618976
12MP0001944_abnormal_pancreas_morphology2.71002749
13MP0002693_abnormal_pancreas_physiology2.69934794
14MP0000013_abnormal_adipose_tissue2.63052443
15MP0009780_abnormal_chondrocyte_physiolo2.55074619
16MP0002877_abnormal_melanocyte_morpholog2.54588118
17MP0002653_abnormal_ependyma_morphology2.54244344
18MP0005220_abnormal_exocrine_pancreas2.49852254
19MP0006292_abnormal_olfactory_placode2.47082792
20MP0004147_increased_porphyrin_level2.41674001
21MP0000678_abnormal_parathyroid_gland2.40082884
22MP0005360_urolithiasis2.34166526
23MP0003646_muscle_fatigue2.30471541
24MP0002139_abnormal_hepatobiliary_system2.17530003
25MP0002909_abnormal_adrenal_gland2.16933865
26MP0009379_abnormal_foot_pigmentation2.14514247
27MP0003195_calcinosis2.10859876
28MP0002938_white_spotting2.10486278
29MP0008872_abnormal_physiological_respon2.03720519
30MP0002138_abnormal_hepatobiliary_system2.01610870
31MP0003300_gastrointestinal_ulcer2.00168536
32MP0005365_abnormal_bile_salt1.94284998
33MP0005085_abnormal_gallbladder_physiolo1.91404640
34MP0009643_abnormal_urine_homeostasis1.87958489
35MP0003868_abnormal_feces_composition1.85698347
36MP0005551_abnormal_eye_electrophysiolog1.80197695
37MP0002837_dystrophic_cardiac_calcinosis1.76800090
38MP0000003_abnormal_adipose_tissue1.73462652
39MP0002102_abnormal_ear_morphology1.72441615
40MP0003252_abnormal_bile_duct1.66733742
41MP0003866_abnormal_defecation1.66640656
42MP0008961_abnormal_basal_metabolism1.65532050
43MP0004019_abnormal_vitamin_homeostasis1.65474265
44MP0006072_abnormal_retinal_apoptosis1.65038424
45MP0001765_abnormal_ion_homeostasis1.64833091
46MP0001756_abnormal_urination1.63267943
47MP0008877_abnormal_DNA_methylation1.60444488
48MP0002160_abnormal_reproductive_system1.60421014
49MP0000538_abnormal_urinary_bladder1.59050807
50MP0005646_abnormal_pituitary_gland1.58764089
51MP0003011_delayed_dark_adaptation1.54756186
52MP0001968_abnormal_touch/_nociception1.54479246
53MP0010352_gastrointestinal_tract_polyps1.54379202
54MP0000566_synostosis1.53344712
55MP0002796_impaired_skin_barrier1.52842614
56MP0000427_abnormal_hair_cycle1.52460897
57MP0003718_maternal_effect1.46889481
58MP0002736_abnormal_nociception_after1.46143973
59MP0002638_abnormal_pupillary_reflex1.44849122
60MP0005379_endocrine/exocrine_gland_phen1.41576397
61MP0004885_abnormal_endolymph1.40291397
62MP0003119_abnormal_digestive_system1.40264534
63MP0002078_abnormal_glucose_homeostasis1.39664742
64MP0008875_abnormal_xenobiotic_pharmacok1.39236879
65MP0002098_abnormal_vibrissa_morphology1.38741671
66MP0004133_heterotaxia1.37335404
67MP0005377_hearing/vestibular/ear_phenot1.33971090
68MP0003878_abnormal_ear_physiology1.33971090
69MP0005389_reproductive_system_phenotype1.31770621
70MP0004782_abnormal_surfactant_physiolog1.31231488
71MP0010678_abnormal_skin_adnexa1.30612978
72MP0005174_abnormal_tail_pigmentation1.28495230
73MP0003879_abnormal_hair_cell1.28306733
74MP0000383_abnormal_hair_follicle1.25024357
75MP0001986_abnormal_taste_sensitivity1.22833195
76MP0002735_abnormal_chemical_nociception1.22632277
77MP0001501_abnormal_sleep_pattern1.21817555
78MP0003890_abnormal_embryonic-extraembry1.21361803
79MP0002733_abnormal_thermal_nociception1.21238306
80MP0002277_abnormal_respiratory_mucosa1.20748638
81MP0005670_abnormal_white_adipose1.19653667
82MP0000537_abnormal_urethra_morphology1.19142170
83MP0002272_abnormal_nervous_system1.16762338
84MP0001664_abnormal_digestion1.15757199
85MP0009745_abnormal_behavioral_response1.14292900
86MP0005636_abnormal_mineral_homeostasis1.12626753
87MP0000613_abnormal_salivary_gland1.12243063
88MP0005171_absent_coat_pigmentation1.11832235
89MP0002234_abnormal_pharynx_morphology1.11625521
90MP0002254_reproductive_system_inflammat1.09830256
91MP0004742_abnormal_vestibular_system1.08811698
92MP0003941_abnormal_skin_development1.08000692
93MP0001485_abnormal_pinna_reflex1.07732974
94MP0002896_abnormal_bone_mineralization1.07524708
95MP0004142_abnormal_muscle_tone1.07446887
96MP0001970_abnormal_pain_threshold1.06845657
97MP0002928_abnormal_bile_duct1.06702946
98MP0005381_digestive/alimentary_phenotyp1.04742814
99MP0001881_abnormal_mammary_gland1.04570326
100MP0001849_ear_inflammation1.02725299
101MP0005084_abnormal_gallbladder_morpholo1.02691330
102MP0003953_abnormal_hormone_level1.01999028
103MP0003787_abnormal_imprinting1.01740447
104MP0003937_abnormal_limbs/digits/tail_de0.99538946
105MP0003938_abnormal_ear_development0.97202518
106MP0000490_abnormal_crypts_of0.96618084
107MP0000026_abnormal_inner_ear0.96423640
108MP0000470_abnormal_stomach_morphology0.96187496
109MP0003638_abnormal_response/metabolism_0.95339880
110MP0002876_abnormal_thyroid_physiology0.95009897
111MP0001764_abnormal_homeostasis0.94978981
112MP0002734_abnormal_mechanical_nocicepti0.94283819
113MP0001873_stomach_inflammation0.94195333
114MP0001188_hyperpigmentation0.91586952
115MP0001919_abnormal_reproductive_system0.91148381
116MP0001486_abnormal_startle_reflex0.90834677
117MP0004145_abnormal_muscle_electrophysio0.90581984
118MP0002060_abnormal_skin_morphology0.90541418
119MP0005408_hypopigmentation0.89275364
120MP0010329_abnormal_lipoprotein_level0.88668607
121MP0005253_abnormal_eye_physiology0.87896825
122MP0005375_adipose_tissue_phenotype0.87310938
123MP0002751_abnormal_autonomic_nervous0.86259458
124MP0002557_abnormal_social/conspecific_i0.84196580
125MP0005410_abnormal_fertilization0.83521273
126MP0003453_abnormal_keratinocyte_physiol0.83479027
127MP0000477_abnormal_intestine_morphology0.83258272
128MP0003137_abnormal_impulse_conducting0.82703069
129MP0005448_abnormal_energy_balance0.81696485
130MP0005248_abnormal_Harderian_gland0.80582143
131MP0005332_abnormal_amino_acid0.80033523
132MP0005075_abnormal_melanosome_morpholog0.79133756
133MP0005076_abnormal_cell_differentiation0.78385591
134MP0002118_abnormal_lipid_homeostasis0.78035208
135MP0001346_abnormal_lacrimal_gland0.77170365
136MP0000049_abnormal_middle_ear0.76878033
137MP0002163_abnormal_gland_morphology0.76427189
138MP0000467_abnormal_esophagus_morphology0.75135080
139MP0000569_abnormal_digit_pigmentation0.74515554
140MP0001186_pigmentation_phenotype0.73743654
141MP0002572_abnormal_emotion/affect_behav0.72236933
142MP0000762_abnormal_tongue_morphology0.70680612
143MP0005645_abnormal_hypothalamus_physiol0.69343377
144MP0005310_abnormal_salivary_gland0.67991991
145MP0001216_abnormal_epidermal_layer0.66026565
146MP0000579_abnormal_nail_morphology0.63390079
147MP0002009_preneoplasia0.63158806
148MP0001663_abnormal_digestive_system0.62993109
149MP0005501_abnormal_skin_physiology0.61376929
150MP0002136_abnormal_kidney_physiology0.59242602
151MP0000631_abnormal_neuroendocrine_gland0.59087373
152MP0000230_abnormal_systemic_arterial0.58994394
153MP0002075_abnormal_coat/hair_pigmentati0.57136459
154MP0001270_distended_abdomen0.56165689
155MP0010155_abnormal_intestine_physiology0.55444372
156MP0005083_abnormal_biliary_tract0.54559011

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.32524481
2Ketoacidosis (HP:0001993)4.74891621
3Abnormal pancreas size (HP:0012094)4.59393735
4Hypoglycemic seizures (HP:0002173)4.58685266
5Malnutrition (HP:0004395)4.33043035
6Symptomatic seizures (HP:0011145)4.32090474
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.21612730
8Hypoglycemic coma (HP:0001325)4.15586535
9Pancreatic cysts (HP:0001737)4.05962480
10Insulin-resistant diabetes mellitus (HP:0000831)3.93629298
11Testicular atrophy (HP:0000029)3.90798237
12Abdominal distention (HP:0003270)3.82383817
13Hyperglycemia (HP:0003074)3.76513151
14Micronodular cirrhosis (HP:0001413)3.76131006
15Decreased circulating renin level (HP:0003351)3.70421413
16Pendular nystagmus (HP:0012043)3.68627358
17Papillary thyroid carcinoma (HP:0002895)3.64805052
18Sensory axonal neuropathy (HP:0003390)3.52446186
19Hyperactive renin-angiotensin system (HP:0000841)3.52055497
20Abnormality of the pancreatic islet cells (HP:0006476)3.48493798
21Abnormality of endocrine pancreas physiology (HP:0012093)3.48493798
22Urinary glycosaminoglycan excretion (HP:0003541)3.48353988
23Mucopolysacchariduria (HP:0008155)3.48353988
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.43943643
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.35731966
26Chronic diarrhea (HP:0002028)3.30543383
27Limb hypertonia (HP:0002509)3.30404128
28Unilateral renal agenesis (HP:0000122)3.29466330
29Abolished electroretinogram (ERG) (HP:0000550)3.25796782
30Abnormality of chloride homeostasis (HP:0011422)3.19722045
31Pancreatic fibrosis (HP:0100732)3.17301279
32Congenital stationary night blindness (HP:0007642)3.16964941
33Abnormality of polysaccharide metabolism (HP:0011012)3.12249218
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.12249218
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.12249218
36Progressive muscle weakness (HP:0003323)3.10524470
37Pancreatic islet-cell hyperplasia (HP:0004510)3.07767458
38Hypokalemia (HP:0002900)3.07368049
39Late onset (HP:0003584)3.06764580
40Abnormality of renin-angiotensin system (HP:0000847)3.06530458
41Exocrine pancreatic insufficiency (HP:0001738)3.06009582
42True hermaphroditism (HP:0010459)3.05174691
43Gout (HP:0001997)3.03482135
44Abnormality of the renal cortex (HP:0011035)2.96041573
45Generalized aminoaciduria (HP:0002909)2.94303910
46Cortical visual impairment (HP:0100704)2.94161466
47Nephronophthisis (HP:0000090)2.89937871
48Abnormality of midbrain morphology (HP:0002418)2.88315279
49Molar tooth sign on MRI (HP:0002419)2.88315279
50Amelogenesis imperfecta (HP:0000705)2.87186609
51Confusion (HP:0001289)2.85127593
52Abnormality of calcium-phosphate metabolism (HP:0100530)2.80709386
53Right ventricular cardiomyopathy (HP:0011663)2.79469010
54Metabolic alkalosis (HP:0200114)2.76144455
55Congenital, generalized hypertrichosis (HP:0004540)2.73258484
56Type II lissencephaly (HP:0007260)2.71636134
57Insulin resistance (HP:0000855)2.69603200
58Ketosis (HP:0001946)2.69380400
59Conjugated hyperbilirubinemia (HP:0002908)2.66463578
60Large for gestational age (HP:0001520)2.62781870
61Abnormality of glycine metabolism (HP:0010895)2.58224360
62Abnormality of serine family amino acid metabolism (HP:0010894)2.58224360
63Abnormality of the renal medulla (HP:0100957)2.58138380
64Abnormality of proline metabolism (HP:0010907)2.57167500
65Hydroxyprolinuria (HP:0003080)2.57167500
66Abnormality of purine metabolism (HP:0004352)2.54690632
67Ileus (HP:0002595)2.54043805
68Hyperparathyroidism (HP:0000843)2.49456456
69Congenital sensorineural hearing impairment (HP:0008527)2.48424542
70Abnormality of vitamin B metabolism (HP:0004340)2.47666310
71Dysostosis multiplex (HP:0000943)2.46216382
72Abnormality of potassium homeostasis (HP:0011042)2.46148726
73Cystic liver disease (HP:0006706)2.42182432
74Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41776408
75Concave nail (HP:0001598)2.41498791
76Hypoplasia of the pons (HP:0012110)2.40991600
77Dyschromatopsia (HP:0007641)2.40683643
78Abnormality of the vitamin B12 metabolism (HP:0004341)2.40352860
79Tubular atrophy (HP:0000092)2.40317346
80Mildly elevated creatine phosphokinase (HP:0008180)2.38308011
81Thyroid carcinoma (HP:0002890)2.35903341
82Microvesicular hepatic steatosis (HP:0001414)2.33136660
83Abnormality of the pons (HP:0007361)2.30397497
84Methylmalonic acidemia (HP:0002912)2.28843278
85Hyperglycinuria (HP:0003108)2.28632362
86Hypoplastic labia majora (HP:0000059)2.26814878
87Cerebellar dysplasia (HP:0007033)2.25782497
88Abnormal biliary tract morphology (HP:0012440)2.23481204
89Aplasia/hypoplasia of the uterus (HP:0008684)2.22791308
90Abnormality of the distal phalanges of the toes (HP:0010182)2.21673880
91Abnormality of small intestinal villus morphology (HP:0011472)2.21598297
92Villous atrophy (HP:0011473)2.21598297
93Hyperphosphatemia (HP:0002905)2.20741640
94Abnormality of alanine metabolism (HP:0010916)2.18554454
95Hyperalaninemia (HP:0003348)2.18554454
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18554454
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16975503
98Dicarboxylic aciduria (HP:0003215)2.16975503
99Furrowed tongue (HP:0000221)2.15663436
100Resting tremor (HP:0002322)2.14766885
101Gastrointestinal dysmotility (HP:0002579)2.14551672
102Pili torti (HP:0003777)2.13845967
103Curly hair (HP:0002212)2.13534853
104Onycholysis (HP:0001806)2.13213592
1053-Methylglutaconic aciduria (HP:0003535)2.12174355
106Chorioretinal atrophy (HP:0000533)2.12043855
107Stomach cancer (HP:0012126)2.11182479
108Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09840828
109Microretrognathia (HP:0000308)2.09799963
110Abnormal albumin level (HP:0012116)2.09639314
111Hypoalbuminemia (HP:0003073)2.09639314
112Glycosuria (HP:0003076)2.06821171
113Abnormality of urine glucose concentration (HP:0011016)2.06821171
114Genetic anticipation (HP:0003743)2.06038799
115Septo-optic dysplasia (HP:0100842)2.05277854
116Attenuation of retinal blood vessels (HP:0007843)2.04998408
117Hypotension (HP:0002615)2.04327393
118Aplasia/Hypoplasia of the uvula (HP:0010293)2.03824140
119Increased corneal curvature (HP:0100692)2.03191069
120Keratoconus (HP:0000563)2.03191069
121Increased CSF protein (HP:0002922)2.01370008
122Decreased central vision (HP:0007663)2.01308437
123Polydipsia (HP:0001959)2.00663564
124Abnormal drinking behavior (HP:0030082)2.00663564
125Hyperglycinemia (HP:0002154)2.00326223
126Abnormality of the intrinsic pathway (HP:0010989)1.98901128
127Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98718831
128Abnormality of the labia majora (HP:0012881)1.98500024
129Renal cortical cysts (HP:0000803)1.98185068
130Facial shape deformation (HP:0011334)1.97730705
131Potter facies (HP:0002009)1.97730705
132Abnormal tarsal ossification (HP:0008369)1.97035660
133Colon cancer (HP:0003003)1.96048514
134Abnormal rod and cone electroretinograms (HP:0008323)1.95766952
135Osteomalacia (HP:0002749)1.95394435
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.95317962
137Popliteal pterygium (HP:0009756)1.95309544
138Atrophic scars (HP:0001075)1.95050545
139Gaze-evoked nystagmus (HP:0000640)1.94932354
140Dehydration (HP:0001944)1.94614090
141Progressive cerebellar ataxia (HP:0002073)1.94335158
142Abnormality of vitamin metabolism (HP:0100508)1.93526976
143Aplasia/Hypoplasia of the patella (HP:0006498)1.91763856
144Progressive sensorineural hearing impairment (HP:0000408)1.91186949
145Abnormality of serum amino acid levels (HP:0003112)1.90879988
146Focal motor seizures (HP:0011153)1.90590909
147Sclerocornea (HP:0000647)1.90519328
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89589767
149Agitation (HP:0000713)1.88355092
150Lip pit (HP:0100267)1.88072999
151Hypokalemic alkalosis (HP:0001949)1.86674672
152Vacuolated lymphocytes (HP:0001922)1.86463194
153Hyperphosphaturia (HP:0003109)1.85892496
154Hypoplasia of dental enamel (HP:0006297)1.85714444
155Alkalosis (HP:0001948)1.85633773
156Optic nerve hypoplasia (HP:0000609)1.85552844
157Lethargy (HP:0001254)1.85446649
158Hypomagnesemia (HP:0002917)1.85412941
159Dynein arm defect of respiratory motile cilia (HP:0012255)1.85324974
160Absent/shortened dynein arms (HP:0200106)1.85324974
161Fat malabsorption (HP:0002630)1.85002566
162Medial flaring of the eyebrow (HP:0010747)1.84970979
163Abnormality of glutamine family amino acid metabolism (HP:0010902)1.84833383
164Methylmalonic aciduria (HP:0012120)1.84323252
165Patellar aplasia (HP:0006443)1.83949747
166Increased circulating renin level (HP:0000848)1.83879292
167Thoracolumbar scoliosis (HP:0002944)1.82399205
168Hypophosphatemia (HP:0002148)1.82305815
169Inability to walk (HP:0002540)1.81270014
170Hypoplasia of the uterus (HP:0000013)1.80807882
171Acute encephalopathy (HP:0006846)1.79960968
172Pigmentary retinal degeneration (HP:0001146)1.79732348
173Male pseudohermaphroditism (HP:0000037)1.79691505
174Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78767624
175Abnormal number of erythroid precursors (HP:0012131)1.78645052
176Mitochondrial inheritance (HP:0001427)1.78506009
177Chronic hepatic failure (HP:0100626)1.78183604
178Acanthocytosis (HP:0001927)1.77644326
179Severe visual impairment (HP:0001141)1.77169512
180Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76148139
181Abnormality of magnesium homeostasis (HP:0004921)1.75928757
182Abnormal respiratory motile cilium morphology (HP:0005938)1.75136927
183Abnormal respiratory epithelium morphology (HP:0012253)1.75136927
184Lipid accumulation in hepatocytes (HP:0006561)1.73662042
185Acute necrotizing encephalopathy (HP:0006965)1.73185720
186Anencephaly (HP:0002323)1.72625623
187Abnormality of macular pigmentation (HP:0008002)1.72061806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.53293987
2PASK5.00558361
3ACVR1B4.49885386
4INSRR4.22082748
5EPHA23.53418620
6BMPR1B3.35276157
7MAP3K23.31312802
8ZAK3.23621330
9MAPK153.21375358
10TNIK3.17264578
11ADRBK22.93539809
12HIPK22.85090905
13MST1R2.61041064
14MST42.45159912
15TAOK32.40168785
16ARAF2.37634039
17EPHA32.34259940
18WNK42.27655320
19MAP2K22.23719539
20ERN12.04806850
21NUAK12.04311615
22CASK2.00709044
23MAP3K91.90305004
24PINK11.87822203
25WNK31.84196580
26TLK11.82670553
27NME11.71413392
28MET1.65292136
29MAP4K21.60833021
30OXSR11.60117969
31PTK61.59616940
32FER1.56754680
33MAP3K131.53171039
34IRAK31.52264034
35MAP3K11.43523161
36BRAF1.42743973
37SGK31.35098932
38MAP3K31.31601303
39DAPK21.28553116
40AKT31.26937335
41SIK11.25384380
42LMTK21.24704859
43DYRK1B1.24183053
44FGFR41.23108536
45KSR21.20890900
46MAPKAPK31.19752112
47MUSK1.17188690
48FLT31.15433793
49PTK21.13101678
50STK31.12641981
51TXK1.11937990
52VRK21.10674455
53EPHB11.10404594
54MKNK21.10189845
55NTRK11.09202291
56RIPK11.08769793
57TAF11.07782839
58LATS11.07774905
59EIF2AK31.07200329
60SCYL21.06545260
61NLK1.05525325
62ADRBK11.01698603
63BCKDK0.98210172
64TGFBR10.95816909
65LATS20.94017416
66TESK10.91350898
67ERBB20.91094124
68PRKCI0.88900153
69PRKD30.84670890
70PIK3CG0.84132796
71PRKG20.83678119
72MAPK130.82579318
73VRK10.81992104
74PDGFRA0.80603896
75STK38L0.80193125
76PRKCG0.79477910
77PNCK0.78858503
78PDGFRB0.77960841
79GSK3A0.75679198
80IRAK10.74543810
81MAP2K10.74509621
82FGFR20.73467988
83NEK20.72821112
84PAK30.71384422
85STK160.69471810
86TRIM280.69183084
87DYRK20.67228695
88DDR20.66479012
89PBK0.65013696
90RPS6KB20.62499993
91STK380.62408853
92PRKCE0.57579431
93BRSK20.57528076
94PRKD20.57044254
95CHUK0.54254347
96IKBKB0.53291779
97CAMK2D0.53283634
98GRK70.53123601
99MAP2K60.52487373
100PLK30.49265283
101CDC42BPA0.49072419
102PLK40.48988088
103STK240.48649758
104MAP3K40.48320307
105TIE10.48309560
106MTOR0.47959329
107PLK10.46170736
108ERBB30.45309895
109MELK0.44971524
110PHKG20.42595446
111PHKG10.42595446
112PIK3CA0.42442219
113TTK0.41207204
114CHEK20.40698130
115STK110.40610214
116GRK50.39376084
117RPS6KA20.38776971
118CAMK2A0.38687614
119GRK60.37635394
120MAPK90.37556687
121CSNK1A1L0.36438527
122MATK0.36387821
123TRIB30.35840520
124CSNK1G10.35778241
125RET0.35362431
126FGFR30.35155202
127PRKCZ0.35020276
128RPS6KA50.33801028
129CSNK1G20.32137922
130CSNK1A10.31879206
131PIM10.30995262
132PRKAA10.30683456
133WEE10.30234547
134PRKCQ0.29337776
135MYLK0.28620008
136RPS6KA40.28594001
137EIF2AK20.25536258
138CSNK2A10.25413857
139CSNK1D0.25400332
140CSNK1E0.25127296
141IGF1R0.24682685
142STK390.23958299
143MAP3K80.22058058
144EPHB20.18602008
145PRKD10.17409420
146GRK10.17071288
147PRKCA0.16918544
148WNK10.16318078
149CAMK2G0.15292896
150NTRK30.13894280
151PRKAA20.13148058
152PRKACA0.12960310
153PDPK10.12170380
154PRKACG0.12088979
155DYRK30.11329868
156MAPKAPK20.11121719
157RPS6KB10.10465977
158JAK20.10398896
159CAMK2B0.09643741
160EEF2K0.09553956
161BMX0.09247527
162AURKB0.09171726
163LRRK20.08942804
164MAPK30.08704445

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.11213120
2Protein export_Homo sapiens_hsa030604.81419127
3Sulfur metabolism_Homo sapiens_hsa009203.77900092
4Insulin secretion_Homo sapiens_hsa049113.15246070
5Vibrio cholerae infection_Homo sapiens_hsa051102.75624803
6Phototransduction_Homo sapiens_hsa047442.45189803
7Fat digestion and absorption_Homo sapiens_hsa049752.33422665
8Folate biosynthesis_Homo sapiens_hsa007902.18731619
9Nitrogen metabolism_Homo sapiens_hsa009102.14475920
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.06475660
11Retinol metabolism_Homo sapiens_hsa008301.97932394
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97273422
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86070562
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.78423806
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69744915
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.68182793
17Type II diabetes mellitus_Homo sapiens_hsa049301.64692495
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62597785
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60689447
20Thyroid hormone synthesis_Homo sapiens_hsa049181.60277552
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.60090301
22Pancreatic secretion_Homo sapiens_hsa049721.57688452
23Nicotine addiction_Homo sapiens_hsa050331.46379884
24Mineral absorption_Homo sapiens_hsa049781.45825225
25Parkinsons disease_Homo sapiens_hsa050121.42794607
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39088652
27Homologous recombination_Homo sapiens_hsa034401.39037784
28Histidine metabolism_Homo sapiens_hsa003401.38939803
29Galactose metabolism_Homo sapiens_hsa000521.36580918
30Protein digestion and absorption_Homo sapiens_hsa049741.32714007
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28844728
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28497571
33Renin-angiotensin system_Homo sapiens_hsa046141.27171360
34Vitamin digestion and absorption_Homo sapiens_hsa049771.26652423
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25681986
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25588719
37Bile secretion_Homo sapiens_hsa049761.24910501
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23994229
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23776040
40Tryptophan metabolism_Homo sapiens_hsa003801.23339441
41Ribosome_Homo sapiens_hsa030101.22404719
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21344307
43N-Glycan biosynthesis_Homo sapiens_hsa005101.18800816
44Linoleic acid metabolism_Homo sapiens_hsa005911.17808448
45RNA polymerase_Homo sapiens_hsa030201.14812691
46Selenocompound metabolism_Homo sapiens_hsa004501.13249351
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11295715
48Regulation of autophagy_Homo sapiens_hsa041401.09127231
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07188917
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07134573
51Huntingtons disease_Homo sapiens_hsa050161.06098774
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02055307
53Basal transcription factors_Homo sapiens_hsa030221.01231592
54Phenylalanine metabolism_Homo sapiens_hsa003601.00560932
55Starch and sucrose metabolism_Homo sapiens_hsa005001.00019184
56beta-Alanine metabolism_Homo sapiens_hsa004100.98948598
57Cocaine addiction_Homo sapiens_hsa050300.97986823
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.95080374
59Sulfur relay system_Homo sapiens_hsa041220.92704996
60Cardiac muscle contraction_Homo sapiens_hsa042600.92161186
61Pentose phosphate pathway_Homo sapiens_hsa000300.91495861
62Butanoate metabolism_Homo sapiens_hsa006500.90426934
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.84608956
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.82053338
65Insulin resistance_Homo sapiens_hsa049310.80970784
66Fructose and mannose metabolism_Homo sapiens_hsa000510.80877028
67One carbon pool by folate_Homo sapiens_hsa006700.80534424
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76452146
69Other glycan degradation_Homo sapiens_hsa005110.76063330
70Estrogen signaling pathway_Homo sapiens_hsa049150.73537175
71ABC transporters_Homo sapiens_hsa020100.70808363
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70688017
73Thyroid cancer_Homo sapiens_hsa052160.69834204
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69746948
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69575590
76Serotonergic synapse_Homo sapiens_hsa047260.69229277
77Fanconi anemia pathway_Homo sapiens_hsa034600.68063233
78Arginine biosynthesis_Homo sapiens_hsa002200.65840875
79Lysosome_Homo sapiens_hsa041420.63825261
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63076127
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.62938965
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.61720764
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60004433
84Olfactory transduction_Homo sapiens_hsa047400.59281496
85Amphetamine addiction_Homo sapiens_hsa050310.58629733
86Bladder cancer_Homo sapiens_hsa052190.58579596
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58568394
88Arachidonic acid metabolism_Homo sapiens_hsa005900.57615890
89Gastric acid secretion_Homo sapiens_hsa049710.57149885
90Arginine and proline metabolism_Homo sapiens_hsa003300.56764781
91Glutathione metabolism_Homo sapiens_hsa004800.56632785
92Tight junction_Homo sapiens_hsa045300.56509180
93Prolactin signaling pathway_Homo sapiens_hsa049170.56455700
94Melanogenesis_Homo sapiens_hsa049160.56399216
95Morphine addiction_Homo sapiens_hsa050320.55849597
96Proteasome_Homo sapiens_hsa030500.55661921
97Fatty acid degradation_Homo sapiens_hsa000710.55572320
98Tyrosine metabolism_Homo sapiens_hsa003500.55286317
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52210839
100RNA degradation_Homo sapiens_hsa030180.49429343
101Propanoate metabolism_Homo sapiens_hsa006400.48041905
102Purine metabolism_Homo sapiens_hsa002300.47893743
103Caffeine metabolism_Homo sapiens_hsa002320.45799574
104Ether lipid metabolism_Homo sapiens_hsa005650.45505764
105Collecting duct acid secretion_Homo sapiens_hsa049660.44281650
106Glucagon signaling pathway_Homo sapiens_hsa049220.43917329
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42775726
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42580397
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42535900
110Asthma_Homo sapiens_hsa053100.42410105
111Basal cell carcinoma_Homo sapiens_hsa052170.41800272
112Cholinergic synapse_Homo sapiens_hsa047250.41438680
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40407096
114Oxidative phosphorylation_Homo sapiens_hsa001900.40127986
115Chemical carcinogenesis_Homo sapiens_hsa052040.40110333
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39898182
117Ovarian steroidogenesis_Homo sapiens_hsa049130.39073522
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38854813
119Salivary secretion_Homo sapiens_hsa049700.38098869
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38038858
121Peroxisome_Homo sapiens_hsa041460.37777821
122Sphingolipid metabolism_Homo sapiens_hsa006000.36317298
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36037863
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35494654
125Circadian rhythm_Homo sapiens_hsa047100.34660149
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32365075
127Alzheimers disease_Homo sapiens_hsa050100.31988755
128Glutamatergic synapse_Homo sapiens_hsa047240.31932204
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31750597
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31359237
131GABAergic synapse_Homo sapiens_hsa047270.31338580
132Pyrimidine metabolism_Homo sapiens_hsa002400.30268673
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29096356
134Metabolic pathways_Homo sapiens_hsa011000.27323087
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26865509
136PPAR signaling pathway_Homo sapiens_hsa033200.26146672
137GnRH signaling pathway_Homo sapiens_hsa049120.24337395
138Gap junction_Homo sapiens_hsa045400.23809241
139cAMP signaling pathway_Homo sapiens_hsa040240.23328141
140Glycerolipid metabolism_Homo sapiens_hsa005610.22778531
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22774267
142Prion diseases_Homo sapiens_hsa050200.22726813
143Renin secretion_Homo sapiens_hsa049240.22293677
144Pyruvate metabolism_Homo sapiens_hsa006200.20571191
145Taste transduction_Homo sapiens_hsa047420.20267874
146Insulin signaling pathway_Homo sapiens_hsa049100.18789812
147Dorso-ventral axis formation_Homo sapiens_hsa043200.18395617

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