MAS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)6.25692806
2branching involved in labyrinthine layer morphogenesis (GO:0060670)6.07905175
3cell wall macromolecule metabolic process (GO:0044036)6.03741883
4cell wall macromolecule catabolic process (GO:0016998)6.03741883
5cilium or flagellum-dependent cell motility (GO:0001539)5.69601708
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.49861372
7acrosome assembly (GO:0001675)5.49758612
8DNA deamination (GO:0045006)5.34809747
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.30509105
10glutamate receptor signaling pathway (GO:0007215)5.15985379
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10292750
12multicellular organism reproduction (GO:0032504)5.03674546
13glutamate secretion (GO:0014047)4.96315878
14protein localization to synapse (GO:0035418)4.96208382
15fusion of sperm to egg plasma membrane (GO:0007342)4.93782298
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.93219160
17synaptic vesicle exocytosis (GO:0016079)4.83149701
18regulation of glutamate receptor signaling pathway (GO:1900449)4.81918457
19behavioral response to nicotine (GO:0035095)4.69585242
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.62782252
21plasma membrane fusion (GO:0045026)4.57215829
22vocalization behavior (GO:0071625)4.51880521
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.44054095
24sperm motility (GO:0030317)4.40516172
25synaptic vesicle maturation (GO:0016188)4.39373122
26regulation of neuronal synaptic plasticity (GO:0048168)4.30939585
27sperm-egg recognition (GO:0035036)4.26845040
28L-fucose catabolic process (GO:0042355)4.22212524
29fucose catabolic process (GO:0019317)4.22212524
30L-fucose metabolic process (GO:0042354)4.22212524
31synaptic transmission, glutamatergic (GO:0035249)4.17529072
32synaptic vesicle docking involved in exocytosis (GO:0016081)4.16700659
33regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15496298
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.11001212
35locomotory exploration behavior (GO:0035641)4.07671886
36neurotransmitter-gated ion channel clustering (GO:0072578)3.97630776
37indolalkylamine catabolic process (GO:0046218)3.97321733
38tryptophan catabolic process (GO:0006569)3.97321733
39indole-containing compound catabolic process (GO:0042436)3.97321733
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.96271522
41behavioral fear response (GO:0001662)3.94068035
42behavioral defense response (GO:0002209)3.94068035
43exploration behavior (GO:0035640)3.92427610
44reproduction (GO:0000003)3.92099147
45regulation of synaptic plasticity (GO:0048167)3.91146448
46sulfation (GO:0051923)3.90552187
47positive regulation of synapse maturation (GO:0090129)3.88492676
48neuron-neuron synaptic transmission (GO:0007270)3.86780106
49kynurenine metabolic process (GO:0070189)3.86562357
50membrane depolarization during action potential (GO:0086010)3.86536032
51regulation of synapse structural plasticity (GO:0051823)3.84753551
52cell-cell recognition (GO:0009988)3.84228504
53indolalkylamine metabolic process (GO:0006586)3.84102390
54calcium ion-dependent exocytosis (GO:0017156)3.82907028
55long-term synaptic potentiation (GO:0060291)3.82516096
56acrosome reaction (GO:0007340)3.78625066
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78547428
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.78547428
59NADH dehydrogenase complex assembly (GO:0010257)3.78547428
60neuronal action potential propagation (GO:0019227)3.77777066
61prostate gland growth (GO:0060736)3.72842951
62serotonin metabolic process (GO:0042428)3.69653188
63regulation of postsynaptic membrane potential (GO:0060078)3.67133802
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.66880059
65negative regulation of mast cell activation (GO:0033004)3.65969845
66cilium movement (GO:0003341)3.62130204
67long-term memory (GO:0007616)3.62122669
68preassembly of GPI anchor in ER membrane (GO:0016254)3.61238265
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61110473
70fear response (GO:0042596)3.60890440
71gamma-aminobutyric acid signaling pathway (GO:0007214)3.58818788
72neuron recognition (GO:0008038)3.57125297
73regulation of synaptic vesicle transport (GO:1902803)3.54491611
74positive regulation of oligodendrocyte differentiation (GO:0048714)3.52005938
75epithelial cilium movement (GO:0003351)3.51561951
76regulation of dendritic spine morphogenesis (GO:0061001)3.51244692
77regulation of synaptic vesicle exocytosis (GO:2000300)3.50624951
78tryptophan metabolic process (GO:0006568)3.50542069
79positive regulation of fibroblast migration (GO:0010763)3.49050141
80negative regulation of Rho protein signal transduction (GO:0035024)3.48406268
81neuron cell-cell adhesion (GO:0007158)3.46740465
82axonemal dynein complex assembly (GO:0070286)3.45551383
83detection of light stimulus involved in sensory perception (GO:0050962)3.45344911
84detection of light stimulus involved in visual perception (GO:0050908)3.45344911
85gamma-aminobutyric acid transport (GO:0015812)3.42013174
86protein localization to cilium (GO:0061512)3.39586255
87synapsis (GO:0007129)3.37015502
88primary amino compound metabolic process (GO:1901160)3.36873326
89positive regulation of membrane potential (GO:0045838)3.36730382
90membrane depolarization (GO:0051899)3.36509971
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.35954023
92water-soluble vitamin biosynthetic process (GO:0042364)3.35942397
93regulation of cell proliferation involved in kidney development (GO:1901722)3.35074509
94response to histamine (GO:0034776)3.32580223
95calcium ion import (GO:0070509)3.32261196
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.32202587
97protein complex biogenesis (GO:0070271)3.29462017
98negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29346983
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27474298
100cochlea development (GO:0090102)3.26554624
101negative regulation of amino acid transport (GO:0051956)3.23511411
102regulation of glutamate secretion (GO:0014048)3.23488873
103sperm capacitation (GO:0048240)3.23203477
104positive regulation of mitochondrial fission (GO:0090141)3.21418503
105cellular potassium ion homeostasis (GO:0030007)3.20403690
106establishment of nucleus localization (GO:0040023)3.20190987
107negative regulation of telomere maintenance (GO:0032205)3.19891670
108male meiosis (GO:0007140)3.19800485
109detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.17924036
110indole-containing compound metabolic process (GO:0042430)3.17469141
111binding of sperm to zona pellucida (GO:0007339)3.17122572
112axonal fasciculation (GO:0007413)3.16108206
113regulation of action potential (GO:0098900)3.15376631
114cell proliferation in forebrain (GO:0021846)3.14598370
115cellular ketone body metabolic process (GO:0046950)3.13614758
116spindle assembly involved in mitosis (GO:0090307)3.11422414
117neurotransmitter secretion (GO:0007269)3.10147232
118cell recognition (GO:0008037)3.07080765
119positive regulation of dendritic spine development (GO:0060999)3.05640466
120mitochondrial respiratory chain complex assembly (GO:0033108)3.05534887
121regulation of vesicle fusion (GO:0031338)3.05514883
122cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05507615
123motile cilium assembly (GO:0044458)3.05277356
124cell communication by electrical coupling (GO:0010644)3.03837082
125regulation of cilium movement (GO:0003352)3.03624495
126transmission of nerve impulse (GO:0019226)3.01991755
127mannosylation (GO:0097502)3.00970583
128regulation of synaptic transmission (GO:0050804)2.98185482
129regulation of energy homeostasis (GO:2000505)2.97702182
130regulation of dendritic spine development (GO:0060998)2.97069688
131startle response (GO:0001964)2.96663372
132cellular sodium ion homeostasis (GO:0006883)2.95609523
133long term synaptic depression (GO:0060292)2.95581814
134neuromuscular process controlling posture (GO:0050884)2.94221819
1353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.93985522
136purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.93985522
137inner ear receptor cell development (GO:0060119)2.93619594
138presynaptic membrane assembly (GO:0097105)2.93096233
139proline transport (GO:0015824)2.93030499
140ventricular system development (GO:0021591)2.92215875
141learning (GO:0007612)2.90053138
142cerebellar Purkinje cell differentiation (GO:0021702)2.89128917
143platelet dense granule organization (GO:0060155)2.88167091
144neuronal action potential (GO:0019228)2.85707692
145ketone body metabolic process (GO:1902224)2.82112263
146regulation of mesoderm development (GO:2000380)2.81865266
147lung-associated mesenchyme development (GO:0060484)2.81685876
148cellular response to ATP (GO:0071318)2.79064525
149negative regulation of systemic arterial blood pressure (GO:0003085)2.77280585
150reflex (GO:0060004)2.76243219
151protein polyglutamylation (GO:0018095)2.75937905
152peristalsis (GO:0030432)2.71994641
153centrosome duplication (GO:0051298)2.71427129
154mitochondrion morphogenesis (GO:0070584)2.71171202
155flavonoid metabolic process (GO:0009812)2.71148425
156response to pheromone (GO:0019236)2.66238282
157presynaptic membrane organization (GO:0097090)2.60629901
158somite development (GO:0061053)2.59903596
159photoreceptor cell development (GO:0042461)2.59453313
160double-strand break repair via homologous recombination (GO:0000724)2.58897147
161neural tube formation (GO:0001841)2.58771239
162dentate gyrus development (GO:0021542)2.57777026
163anterior/posterior axis specification, embryo (GO:0008595)2.57395568
164regulation of collateral sprouting (GO:0048670)2.57272744
165recombinational repair (GO:0000725)2.56748769
166regulation of memory T cell differentiation (GO:0043380)2.56270718
167axoneme assembly (GO:0035082)2.55446729
168positive regulation of fatty acid oxidation (GO:0046321)2.53405234
169amine catabolic process (GO:0009310)2.52505586
170cellular biogenic amine catabolic process (GO:0042402)2.52505586
171negative regulation of DNA-dependent DNA replication (GO:2000104)2.51035298
172regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.50463151
173regulation of neurotransmitter uptake (GO:0051580)2.48995567
174microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.48527305
175auditory receptor cell stereocilium organization (GO:0060088)2.47331135
176piRNA metabolic process (GO:0034587)2.46356974
177regulation of nuclear cell cycle DNA replication (GO:0033262)2.46048151
178positive regulation of defense response to virus by host (GO:0002230)2.45699101
179regulation of mitochondrial fission (GO:0090140)2.45409567
180regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45345177
181regulation of telomere maintenance (GO:0032204)2.45279891
182response to lipoprotein particle (GO:0055094)2.44941833
183magnesium ion transport (GO:0015693)2.44026828
184negative regulation of kidney development (GO:0090185)2.42772330
185retinal cone cell development (GO:0046549)2.39413094
186negative regulation of multicellular organism growth (GO:0040015)2.38527630
187DNA methylation involved in gamete generation (GO:0043046)2.38400212
188kidney morphogenesis (GO:0060993)2.37540519
189eye photoreceptor cell development (GO:0042462)2.36208087
190regulation of translation, ncRNA-mediated (GO:0045974)2.35630288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.61266806
2GBX2_23144817_ChIP-Seq_PC3_Human3.73182338
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54189078
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.64731169
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58295809
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56209150
7REST_21632747_ChIP-Seq_MESCs_Mouse2.43066280
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39327486
9IGF1R_20145208_ChIP-Seq_DFB_Human2.27752639
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25769105
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22426155
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20774786
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13501828
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.13038811
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12611303
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11924393
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11924393
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11767404
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08316346
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.05563768
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03947646
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03048612
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02682676
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01749574
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.98225354
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95111105
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94871230
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.93663698
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92791864
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.91479728
31ZNF274_21170338_ChIP-Seq_K562_Hela1.91189613
32EWS_26573619_Chip-Seq_HEK293_Human1.90650967
33DROSHA_22980978_ChIP-Seq_HELA_Human1.88671435
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.87371603
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84004297
36VDR_22108803_ChIP-Seq_LS180_Human1.82256652
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.81966775
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80791031
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79819781
40IRF1_19129219_ChIP-ChIP_H3396_Human1.78946027
41BCAT_22108803_ChIP-Seq_LS180_Human1.72629008
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72604209
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71064806
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70713352
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67500205
46SMAD4_21799915_ChIP-Seq_A2780_Human1.66186166
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63978030
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.59695784
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59651123
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57884684
51TAF15_26573619_Chip-Seq_HEK293_Human1.55930368
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49968347
53* P300_19829295_ChIP-Seq_ESCs_Human1.49789287
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.45692156
55MYC_18940864_ChIP-ChIP_HL60_Human1.45433724
56RNF2_27304074_Chip-Seq_NSC_Mouse1.44561100
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41863301
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37261034
59FUS_26573619_Chip-Seq_HEK293_Human1.33133951
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32956411
61AR_25329375_ChIP-Seq_VCAP_Human1.32950673
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32722729
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.32142183
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31643119
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30792377
66TP53_22573176_ChIP-Seq_HFKS_Human1.27967244
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27539963
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.27153145
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.25238759
70* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23816282
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23767840
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.23749963
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23749963
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23391242
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22969504
76NANOG_19829295_ChIP-Seq_ESCs_Human1.22941618
77SOX2_19829295_ChIP-Seq_ESCs_Human1.22941618
78* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22399466
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22239167
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.21260236
81NCOR_22424771_ChIP-Seq_293T_Human1.20466589
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18685931
83* STAT3_23295773_ChIP-Seq_U87_Human1.18625184
84TCF4_22108803_ChIP-Seq_LS180_Human1.18478871
85KDM2B_26808549_Chip-Seq_REH_Human1.18452389
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18416610
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18390638
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.18003685
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.17390142
90RUNX2_22187159_ChIP-Seq_PCA_Human1.17303841
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15014255
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.14890564
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14566207
94* TCF4_23295773_ChIP-Seq_U87_Human1.14008193
95* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13632195
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13496898
97AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13354690
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13108273
99CBP_20019798_ChIP-Seq_JUKART_Human1.13103513
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13103513
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12129333
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11027366
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11027366
104P53_22387025_ChIP-Seq_ESCs_Mouse1.10905563
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10079177
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.09757831
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09610409
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.09284965
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.07851371
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07467225
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.07412772
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.06063934
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.05586391
114SOX2_18555785_Chip-Seq_ESCs_Mouse1.04617096
115AR_21572438_ChIP-Seq_LNCaP_Human1.03901454
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03741268
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03568812
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03552550
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02638082
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02186314
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02125924
122* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01857335
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01028535
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.00970230
125GABP_17652178_ChIP-ChIP_JURKAT_Human1.00583096
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00337080
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.00257564
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99530778
129AR_19668381_ChIP-Seq_PC3_Human0.99343205
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99149902
131P300_18555785_Chip-Seq_ESCs_Mouse0.99092716
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98153857
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97683666
134SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97056175
135ER_23166858_ChIP-Seq_MCF-7_Human0.96958196
136RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96866141
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.96478151
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96134627
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.95923402
140SOX9_26525672_Chip-Seq_HEART_Mouse0.95798001
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.94734857
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94574738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.97981819
2MP0003880_abnormal_central_pattern5.43945183
3* MP0003635_abnormal_synaptic_transmissio4.06547352
4MP0005410_abnormal_fertilization3.93478406
5MP0009745_abnormal_behavioral_response3.56776309
6MP0002063_abnormal_learning/memory/cond3.43830649
7MP0004270_analgesia3.25804487
8MP0002064_seizures3.03297141
9MP0009046_muscle_twitch2.96081316
10MP0001968_abnormal_touch/_nociception2.87535125
11MP0002736_abnormal_nociception_after2.81932389
12* MP0002572_abnormal_emotion/affect_behav2.79492157
13MP0003195_calcinosis2.73365110
14MP0001440_abnormal_grooming_behavior2.66553827
15MP0002735_abnormal_chemical_nociception2.49023195
16MP0002102_abnormal_ear_morphology2.38609191
17MP0002272_abnormal_nervous_system2.32796652
18MP0000569_abnormal_digit_pigmentation2.23075283
19MP0001486_abnormal_startle_reflex2.21526791
20MP0002822_catalepsy2.21262860
21MP0001501_abnormal_sleep_pattern2.18440775
22MP0003879_abnormal_hair_cell2.05220455
23MP0000516_abnormal_urinary_system2.04356220
24MP0005367_renal/urinary_system_phenotyp2.04356220
25MP0002138_abnormal_hepatobiliary_system1.96858252
26MP0003329_amyloid_beta_deposits1.88075291
27MP0006072_abnormal_retinal_apoptosis1.86795961
28MP0002734_abnormal_mechanical_nocicepti1.86271416
29MP0008877_abnormal_DNA_methylation1.77732930
30MP0003787_abnormal_imprinting1.77690119
31MP0002067_abnormal_sensory_capabilities1.73411763
32MP0005253_abnormal_eye_physiology1.71349166
33MP0002837_dystrophic_cardiac_calcinosis1.70317533
34MP0003698_abnormal_male_reproductive1.68697830
35MP0000631_abnormal_neuroendocrine_gland1.67611750
36MP0000372_irregular_coat_pigmentation1.66685023
37MP0002160_abnormal_reproductive_system1.65923202
38MP0005670_abnormal_white_adipose1.65734730
39MP0003718_maternal_effect1.52866845
40MP0001905_abnormal_dopamine_level1.50968395
41MP0009780_abnormal_chondrocyte_physiolo1.50813245
42MP0000778_abnormal_nervous_system1.50746165
43MP0002733_abnormal_thermal_nociception1.49295979
44MP0001970_abnormal_pain_threshold1.48727355
45MP0001986_abnormal_taste_sensitivity1.46810772
46MP0005646_abnormal_pituitary_gland1.44702899
47MP0004811_abnormal_neuron_physiology1.43599449
48MP0006276_abnormal_autonomic_nervous1.42807518
49MP0002184_abnormal_innervation1.41757904
50MP0005389_reproductive_system_phenotype1.41552299
51MP0002638_abnormal_pupillary_reflex1.40929413
52MP0002557_abnormal_social/conspecific_i1.38744994
53MP0002653_abnormal_ependyma_morphology1.38650261
54MP0008569_lethality_at_weaning1.37523226
55MP0005084_abnormal_gallbladder_morpholo1.36675498
56MP0003136_yellow_coat_color1.34163548
57MP0005423_abnormal_somatic_nervous1.33457553
58MP0005623_abnormal_meninges_morphology1.33294237
59MP0001765_abnormal_ion_homeostasis1.32458836
60MP0002751_abnormal_autonomic_nervous1.32154909
61MP0001502_abnormal_circadian_rhythm1.32140117
62MP0003119_abnormal_digestive_system1.28779428
63MP0004885_abnormal_endolymph1.27586254
64MP0004858_abnormal_nervous_system1.25571980
65MP0004924_abnormal_behavior1.25478027
66MP0005386_behavior/neurological_phenoty1.25478027
67MP0003633_abnormal_nervous_system1.25465783
68MP0002876_abnormal_thyroid_physiology1.25271264
69MP0000383_abnormal_hair_follicle1.24314837
70MP0002066_abnormal_motor_capabilities/c1.24303131
71MP0002909_abnormal_adrenal_gland1.22478212
72MP0006292_abnormal_olfactory_placode1.22200109
73MP0000427_abnormal_hair_cycle1.21553680
74MP0002882_abnormal_neuron_morphology1.20953018
75MP0003283_abnormal_digestive_organ1.19504287
76MP0000955_abnormal_spinal_cord1.19107576
77MP0001929_abnormal_gametogenesis1.18823607
78MP0000049_abnormal_middle_ear1.18777359
79MP0003890_abnormal_embryonic-extraembry1.17395738
80MP0002234_abnormal_pharynx_morphology1.16706070
81MP0002938_white_spotting1.16597718
82MP0003011_delayed_dark_adaptation1.15392096
83MP0002928_abnormal_bile_duct1.15344321
84MP0001984_abnormal_olfaction1.13716542
85MP0005174_abnormal_tail_pigmentation1.13272531
86MP0004147_increased_porphyrin_level1.11422829
87MP0003183_abnormal_peptide_metabolism1.10962436
88MP0003315_abnormal_perineum_morphology1.10420988
89MP0003631_nervous_system_phenotype1.08531455
90MP0005195_abnormal_posterior_eye1.07527191
91MP0008875_abnormal_xenobiotic_pharmacok1.07409275
92MP0000751_myopathy1.06892152
93MP0003693_abnormal_embryo_hatching1.02719407
94MP0004215_abnormal_myocardial_fiber1.00069843
95MP0003075_altered_response_to0.96739175
96MP0004085_abnormal_heartbeat0.95676192
97MP0004130_abnormal_muscle_cell0.95516372
98MP0002152_abnormal_brain_morphology0.94352960
99MP0003937_abnormal_limbs/digits/tail_de0.93036051
100MP0003122_maternal_imprinting0.92526677
101MP0000604_amyloidosis0.91292910
102MP0005535_abnormal_body_temperature0.90347681
103MP0005075_abnormal_melanosome_morpholog0.89805644
104MP0002282_abnormal_trachea_morphology0.89359170
105MP0002095_abnormal_skin_pigmentation0.87722615
106MP0002161_abnormal_fertility/fecundity0.87610302
107MP0004142_abnormal_muscle_tone0.86499305
108MP0005171_absent_coat_pigmentation0.86485966
109MP0001963_abnormal_hearing_physiology0.84853898
110MP0002069_abnormal_eating/drinking_beha0.84564500
111MP0008872_abnormal_physiological_respon0.84195847
112MP0003724_increased_susceptibility_to0.83424324
113MP0000230_abnormal_systemic_arterial0.82959304
114MP0001529_abnormal_vocalization0.82864570
115MP0004145_abnormal_muscle_electrophysio0.82722808
116MP0004484_altered_response_of0.81866705
117MP0001485_abnormal_pinna_reflex0.80871254
118MP0000015_abnormal_ear_pigmentation0.80535214
119MP0001664_abnormal_digestion0.80173205
120MP0002229_neurodegeneration0.78491519
121MP0002163_abnormal_gland_morphology0.77438386
122MP0003252_abnormal_bile_duct0.77127151
123MP0008874_decreased_physiological_sensi0.76329915
124MP0002693_abnormal_pancreas_physiology0.75021560
125MP0001919_abnormal_reproductive_system0.73604197
126MP0005551_abnormal_eye_electrophysiolog0.73497586
127MP0005645_abnormal_hypothalamus_physiol0.73344154
128MP0001188_hyperpigmentation0.73113780
129MP0005379_endocrine/exocrine_gland_phen0.72725433
130MP0003936_abnormal_reproductive_system0.72672607
131MP0008789_abnormal_olfactory_epithelium0.72423569
132MP0004043_abnormal_pH_regulation0.71742272
133MP0005595_abnormal_vascular_smooth0.71565366
134MP0004742_abnormal_vestibular_system0.67752912
135MP0003632_abnormal_nervous_system0.66601849
136MP0004233_abnormal_muscle_weight0.64630191
137MP0003646_muscle_fatigue0.64230810
138MP0001177_atelectasis0.64217150
139MP0003123_paternal_imprinting0.62573245
140MP0002752_abnormal_somatic_nervous0.62096834
141MP0000678_abnormal_parathyroid_gland0.61718402
142MP0004510_myositis0.61000975
143MP0000026_abnormal_inner_ear0.60483474
144MP0000013_abnormal_adipose_tissue0.58350489
145MP0003137_abnormal_impulse_conducting0.55674196
146MP0010386_abnormal_urinary_bladder0.52860686
147MP0004133_heterotaxia0.52025821
148MP0003938_abnormal_ear_development0.50372873
149MP0003861_abnormal_nervous_system0.50204672

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.01719971
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.93257081
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.69664971
4Absent/shortened dynein arms (HP:0200106)5.69664971
5Abnormality of the lower motor neuron (HP:0002366)5.65691668
6Myokymia (HP:0002411)5.22402632
7Abnormal respiratory motile cilium physiology (HP:0012261)4.93898444
8Epileptic encephalopathy (HP:0200134)4.86079947
9Abnormal ciliary motility (HP:0012262)4.70552728
10Focal seizures (HP:0007359)4.69228707
11Atonic seizures (HP:0010819)4.32114199
12Abnormal respiratory epithelium morphology (HP:0012253)3.89840783
13Abnormal respiratory motile cilium morphology (HP:0005938)3.89840783
14Febrile seizures (HP:0002373)3.85147137
15Rhinitis (HP:0012384)3.84870448
16Congenital stationary night blindness (HP:0007642)3.79520277
17Visual hallucinations (HP:0002367)3.69745112
18Pancreatic cysts (HP:0001737)3.69007697
19Progressive cerebellar ataxia (HP:0002073)3.63150054
20Short 1st metacarpal (HP:0010034)3.58511791
21Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.58511791
22Pendular nystagmus (HP:0012043)3.56969193
23Impaired smooth pursuit (HP:0007772)3.53858644
24Ectopic kidney (HP:0000086)3.46294636
25Stenosis of the external auditory canal (HP:0000402)3.38363883
26Pancreatic fibrosis (HP:0100732)3.37923493
27Hyperventilation (HP:0002883)3.29896463
28Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.25216211
29Absence seizures (HP:0002121)3.24446350
30Dialeptic seizures (HP:0011146)3.24039873
31Impaired vibration sensation in the lower limbs (HP:0002166)3.18365758
32Abnormality of the 1st metacarpal (HP:0010009)3.11830837
33True hermaphroditism (HP:0010459)3.10236419
34Absent thumb (HP:0009777)3.08046305
35Abolished electroretinogram (ERG) (HP:0000550)3.04867076
36Abnormality of ocular smooth pursuit (HP:0000617)3.03987170
37Amblyopia (HP:0000646)2.97825536
38Abnormality of the renal collecting system (HP:0004742)2.93604950
39Duplicated collecting system (HP:0000081)2.91447586
40Chronic bronchitis (HP:0004469)2.88445167
41Gaze-evoked nystagmus (HP:0000640)2.86472173
42Generalized tonic-clonic seizures (HP:0002069)2.84532873
43Decreased circulating renin level (HP:0003351)2.80264719
44Dysmetria (HP:0001310)2.77823205
45Abnormality of DNA repair (HP:0003254)2.76182791
46Abnormality of saccadic eye movements (HP:0000570)2.75081506
47Spontaneous abortion (HP:0005268)2.73013281
48Increased circulating renin level (HP:0000848)2.68276486
49Medial flaring of the eyebrow (HP:0010747)2.67247656
50Truncal ataxia (HP:0002078)2.66829662
51Increased corneal curvature (HP:0100692)2.62351405
52Keratoconus (HP:0000563)2.62351405
53Infertility (HP:0000789)2.61581819
54Retinal dysplasia (HP:0007973)2.60914376
55Carpal bone hypoplasia (HP:0001498)2.60255252
56Attenuation of retinal blood vessels (HP:0007843)2.59153903
57Dysdiadochokinesis (HP:0002075)2.55204076
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53508137
59Epileptiform EEG discharges (HP:0011182)2.53180518
60Abnormality of the renal medulla (HP:0100957)2.52166067
61Abnormality of the renal cortex (HP:0011035)2.51829876
62Tachypnea (HP:0002789)2.47049924
63Thyroiditis (HP:0100646)2.46558110
64Cerebral inclusion bodies (HP:0100314)2.44612855
65Short hallux (HP:0010109)2.43136657
66Type II lissencephaly (HP:0007260)2.40673110
67Urinary bladder sphincter dysfunction (HP:0002839)2.40345992
68Limb ataxia (HP:0002070)2.38997222
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.37952245
70Short phalanx of the thumb (HP:0009660)2.37854825
71Chorioretinal atrophy (HP:0000533)2.36719233
72Bony spicule pigmentary retinopathy (HP:0007737)2.34938066
73Drooling (HP:0002307)2.33973726
74Excessive salivation (HP:0003781)2.33973726
75Abnormality of midbrain morphology (HP:0002418)2.32803206
76Molar tooth sign on MRI (HP:0002419)2.32803206
77Abnormality of the parathyroid morphology (HP:0011766)2.31749318
78Chromsome breakage (HP:0040012)2.30859078
79Broad-based gait (HP:0002136)2.29238013
80Aplasia/Hypoplasia of the hallux (HP:0008362)2.28408846
81Supranuclear gaze palsy (HP:0000605)2.27927585
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.24877019
83Dysmetric saccades (HP:0000641)2.24810776
84Congenital sensorineural hearing impairment (HP:0008527)2.24123925
85Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23948891
86Gait imbalance (HP:0002141)2.23573443
87Nephronophthisis (HP:0000090)2.20379104
88Abnormal rod and cone electroretinograms (HP:0008323)2.19132829
89Hypoproteinemia (HP:0003075)2.18132991
90Anxiety (HP:0000739)2.16752633
91Impaired vibratory sensation (HP:0002495)2.16317828
92Abnormal eating behavior (HP:0100738)2.15994883
93Hyperactive renin-angiotensin system (HP:0000841)2.15956841
94Depression (HP:0000716)2.15709038
95Difficulty climbing stairs (HP:0003551)2.15276094
96Action tremor (HP:0002345)2.14973013
97Cystic liver disease (HP:0006706)2.13802311
98Hemiparesis (HP:0001269)2.12717765
99Hyperkalemia (HP:0002153)2.12262367
100Congenital primary aphakia (HP:0007707)2.12254453
101Genetic anticipation (HP:0003743)2.11942361
102Decreased central vision (HP:0007663)2.10455637
103Ventricular fibrillation (HP:0001663)2.08776492
104Stomach cancer (HP:0012126)2.05964113
105Scanning speech (HP:0002168)2.05757300
106Poor eye contact (HP:0000817)2.04466480
107Inability to walk (HP:0002540)2.03102616
108Urinary urgency (HP:0000012)2.02787955
109Polydipsia (HP:0001959)2.02025944
110Abnormal drinking behavior (HP:0030082)2.02025944
111Absent speech (HP:0001344)2.01912345
112Acute necrotizing encephalopathy (HP:0006965)2.01734637
113Postural instability (HP:0002172)2.01384914
114Panhypogammaglobulinemia (HP:0003139)1.99628407
115Gait ataxia (HP:0002066)1.99294538
116Chronic hepatic failure (HP:0100626)1.98219271
117EEG with generalized epileptiform discharges (HP:0011198)1.97863283
118Abnormality of B cell number (HP:0010975)1.97261573
119Abnormality of the ileum (HP:0001549)1.96703071
120Abnormal gallbladder physiology (HP:0012438)1.96211272
121Cholecystitis (HP:0001082)1.96211272
122Progressive inability to walk (HP:0002505)1.96148723
123Status epilepticus (HP:0002133)1.96134984
124Protruding tongue (HP:0010808)1.95873458
125Severe muscular hypotonia (HP:0006829)1.95454109
126Tubular atrophy (HP:0000092)1.95357954
127Severe combined immunodeficiency (HP:0004430)1.94989665
128Abnormality of alanine metabolism (HP:0010916)1.93406992
129Hyperalaninemia (HP:0003348)1.93406992
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93406992
131Spinal muscular atrophy (HP:0007269)1.93010073
132Meckel diverticulum (HP:0002245)1.92849800
133Rectal fistula (HP:0100590)1.91468930
134Rectovaginal fistula (HP:0000143)1.91468930
135Methylmalonic acidemia (HP:0002912)1.90845704
136Neurofibrillary tangles (HP:0002185)1.90334536
137Absent forearm bone (HP:0003953)1.90156316
138Aplasia involving forearm bones (HP:0009822)1.90156316
139Progressive macrocephaly (HP:0004481)1.89500303
140Absent radius (HP:0003974)1.87901700
141Sclerocornea (HP:0000647)1.87823647
142Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87708328
143Furrowed tongue (HP:0000221)1.86800094
144Delusions (HP:0000746)1.86617244
145Fused cervical vertebrae (HP:0002949)1.86570408
146Stereotypic behavior (HP:0000733)1.86517431
147Slow saccadic eye movements (HP:0000514)1.86021214
148Nephrogenic diabetes insipidus (HP:0009806)1.85990610
149Horseshoe kidney (HP:0000085)1.85855611
150Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.85678580
151Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85500368
152Hypoplasia of the pons (HP:0012110)1.84912711
153Mitochondrial inheritance (HP:0001427)1.84077055
154Spastic gait (HP:0002064)1.83756147
155Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83735858
156Abnormality of binocular vision (HP:0011514)1.83363011
157Diplopia (HP:0000651)1.83363011
158Neoplasm of the oral cavity (HP:0100649)1.82276552
159Generalized myoclonic seizures (HP:0002123)1.82138760
160Abnormality of the pons (HP:0007361)1.81869576
161Clubbing of toes (HP:0100760)1.81702961
162Blue irides (HP:0000635)1.81216511
163Abnormality of the carotid arteries (HP:0005344)1.81173671
164Congenital, generalized hypertrichosis (HP:0004540)1.79889156
165B lymphocytopenia (HP:0010976)1.79235650
166Hypsarrhythmia (HP:0002521)1.78088510
167Large for gestational age (HP:0001520)1.77956793
168Syncope (HP:0001279)1.77640087
169Impaired social interactions (HP:0000735)1.77323569
170Abnormal social behavior (HP:0012433)1.77323569
171Congenital malformation of the right heart (HP:0011723)1.76615317
172Double outlet right ventricle (HP:0001719)1.76615317
173Ankle clonus (HP:0011448)1.76447423
174Bronchiectasis (HP:0002110)1.75391537
175Abnormal spermatogenesis (HP:0008669)1.74981413
176Confusion (HP:0001289)1.73604984
177Bradykinesia (HP:0002067)1.71260452
178Degeneration of the lateral corticospinal tracts (HP:0002314)1.70760539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.16759089
2EPHA45.92900650
3NTRK35.86967874
4GRK13.68119466
5BMPR1B3.66870739
6ADRBK23.37416627
7MAP3K93.25048357
8TLK13.10191036
9PTK2B3.01259704
10MAP2K72.98551822
11MAP3K42.52378969
12ZAK2.50827685
13ACVR1B2.45316588
14RIPK42.28395114
15NUAK12.16727506
16MAP4K22.14437075
17KSR22.09562181
18PLK22.08211729
19PRKD32.06001348
20TAOK32.05625019
21ARAF1.94688319
22PDK31.89395673
23PDK41.89395673
24DAPK21.88488338
25MAP3K131.86792618
26MINK11.84769937
27INSRR1.77917180
28CASK1.72197199
29DAPK11.70216091
30TNIK1.68794351
31MAP2K41.64861116
32MAP3K121.61715321
33KSR11.61308624
34CDK191.61130449
35NTRK21.58274462
36MKNK21.50307765
37PRPF4B1.41798432
38STK381.38486370
39PNCK1.38311522
40WNK41.30083695
41GRK51.28359665
42CDK51.24856148
43CAMK2B1.24442384
44PRKCG1.24396742
45CAMK11.23565156
46TXK1.21951195
47PAK61.21582166
48FES1.20487932
49TGFBR11.19807300
50CAMK2A1.17280934
51PDK21.16292821
52PIK3CA1.15521421
53MARK21.10581206
54BMPR21.05778731
55TRIM281.05350077
56CAMKK11.04970738
57MAP3K21.04318487
58BRAF1.02664856
59VRK11.00633251
60ADRBK10.99344696
61OXSR10.97806284
62FGFR20.97694424
63RAF10.97355460
64MARK10.94437489
65STK390.93993595
66PDK10.89510509
67DYRK20.88089121
68TAF10.87191834
69VRK20.84749349
70LMTK20.83922995
71MAPK130.83468921
72FGR0.82495321
73CAMKK20.82080353
74CDK90.81108019
75CSNK1G10.80943590
76MAP2K60.80799365
77PDPK10.79710668
78AKT30.79502506
79CSNK1G30.78704599
80NME10.78573808
81CCNB10.78391471
82CAMK1G0.75832607
83CSNK1A1L0.74303321
84MKNK10.73466028
85CDK180.72242026
86SIK20.71675998
87PRKCH0.70926604
88CDK150.69973895
89FER0.69883912
90MAP3K10.67681260
91MAP3K60.66640115
92TNK20.66061920
93IKBKB0.65618415
94KIT0.64838656
95FLT30.64816300
96GRK70.64421052
97MAPKAPK50.63581339
98CDK11A0.62633159
99CSNK1A10.61320576
100STK38L0.60576993
101TEC0.59441709
102PHKG20.59342399
103PHKG10.59342399
104CDK140.59203056
105TYRO30.58997671
106CSNK1D0.57840020
107SYK0.56542430
108CAMK2D0.55337649
109CDC70.55290681
110SGK10.55159071
111NLK0.55068766
112MOS0.54271193
113UHMK10.51834585
114STK30.51151888
115NTRK10.51058262
116ATR0.51034460
117MAPKAPK30.50892056
118MUSK0.50772081
119RPS6KA50.48611430
120DYRK1A0.48495867
121MST40.46998836
122MAP3K70.46614244
123PRKCE0.45640584
124SGK2230.45414264
125SGK4940.45414264
126PKN10.43418396
127TIE10.43408066
128GRK60.42635906
129CAMK2G0.42218227
130WNK30.38776218
131CAMK1D0.37888051
132PRKG10.37819902
133NEK60.37712581
134SGK20.37438652
135PRKCI0.37141543
136PINK10.37132034
137MAP2K10.36942575
138ERBB30.36804035
139PLK30.36803697
140PAK30.36587157
141ITK0.35836695
142STK110.35611256
143PRKCA0.34567527
144PRKAA10.34523252
145SIK30.34516805
146CAMK40.34366879
147ERBB20.33572730
148PRKD20.33307650
149BCKDK0.33021985
150CHEK20.32343200
151CDC42BPA0.31760542
152DYRK30.30967021
153PLK40.30296067
154RPS6KA30.29635978
155RET0.28819642
156PRKCZ0.28294403
157PRKACA0.28019234
158MAPK120.27420059
159MAPK70.26044108
160PRKCQ0.25619650
161CSNK1G20.25435425
162MAPK100.25108569

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.21053277
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.30700203
3Long-term potentiation_Homo sapiens_hsa047203.24524191
4Synaptic vesicle cycle_Homo sapiens_hsa047213.22944336
5Circadian entrainment_Homo sapiens_hsa047133.13643772
6Amphetamine addiction_Homo sapiens_hsa050312.95627014
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85805710
8Glutamatergic synapse_Homo sapiens_hsa047242.74606997
9Olfactory transduction_Homo sapiens_hsa047402.56560092
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.47406924
11Morphine addiction_Homo sapiens_hsa050322.33811293
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.33809660
13Salivary secretion_Homo sapiens_hsa049702.31850384
14GABAergic synapse_Homo sapiens_hsa047272.27346581
15Linoleic acid metabolism_Homo sapiens_hsa005912.26929358
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23192196
17Collecting duct acid secretion_Homo sapiens_hsa049662.22093035
18Nitrogen metabolism_Homo sapiens_hsa009102.20303604
19Homologous recombination_Homo sapiens_hsa034402.14662413
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11197720
21Dopaminergic synapse_Homo sapiens_hsa047282.08384300
22Insulin secretion_Homo sapiens_hsa049112.08125823
23Calcium signaling pathway_Homo sapiens_hsa040202.06716421
24Butanoate metabolism_Homo sapiens_hsa006502.00477956
25Taste transduction_Homo sapiens_hsa047421.99879977
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94399226
27Renin secretion_Homo sapiens_hsa049241.87596638
28Oxytocin signaling pathway_Homo sapiens_hsa049211.81812240
29Fanconi anemia pathway_Homo sapiens_hsa034601.81724155
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79792890
31Gastric acid secretion_Homo sapiens_hsa049711.77738528
32Ether lipid metabolism_Homo sapiens_hsa005651.73254781
33Long-term depression_Homo sapiens_hsa047301.69235139
34Selenocompound metabolism_Homo sapiens_hsa004501.68857587
35Tryptophan metabolism_Homo sapiens_hsa003801.67298065
36RNA polymerase_Homo sapiens_hsa030201.59987749
37Cholinergic synapse_Homo sapiens_hsa047251.59117603
38Serotonergic synapse_Homo sapiens_hsa047261.56783385
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50832767
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.49974763
41cAMP signaling pathway_Homo sapiens_hsa040241.49553065
42Cocaine addiction_Homo sapiens_hsa050301.48239263
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47031181
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44241353
45Caffeine metabolism_Homo sapiens_hsa002321.40003542
46Primary immunodeficiency_Homo sapiens_hsa053401.35180775
47Asthma_Homo sapiens_hsa053101.31978113
48GnRH signaling pathway_Homo sapiens_hsa049121.30499562
49* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26195035
50Basal transcription factors_Homo sapiens_hsa030221.26185372
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25276785
52Cardiac muscle contraction_Homo sapiens_hsa042601.24681168
53Chemical carcinogenesis_Homo sapiens_hsa052041.23107706
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22294624
55Vibrio cholerae infection_Homo sapiens_hsa051101.21684325
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20158634
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18059046
58RNA degradation_Homo sapiens_hsa030181.14367356
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13905490
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13381309
61Protein export_Homo sapiens_hsa030601.12984483
62Sulfur metabolism_Homo sapiens_hsa009201.12289727
63Glucagon signaling pathway_Homo sapiens_hsa049221.10230159
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08522209
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.08202716
66Estrogen signaling pathway_Homo sapiens_hsa049151.06748265
67Retinol metabolism_Homo sapiens_hsa008301.05366997
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05048112
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04829722
70Vascular smooth muscle contraction_Homo sapiens_hsa042701.04453416
71Axon guidance_Homo sapiens_hsa043601.03818298
72Gap junction_Homo sapiens_hsa045401.01288926
73Parkinsons disease_Homo sapiens_hsa050120.98347120
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96968724
75Oocyte meiosis_Homo sapiens_hsa041140.92839620
76ABC transporters_Homo sapiens_hsa020100.92673456
77Type II diabetes mellitus_Homo sapiens_hsa049300.90944167
78Pancreatic secretion_Homo sapiens_hsa049720.90676307
79Melanogenesis_Homo sapiens_hsa049160.89991465
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88122640
81Thyroid hormone synthesis_Homo sapiens_hsa049180.86770223
82Peroxisome_Homo sapiens_hsa041460.82884981
83Arachidonic acid metabolism_Homo sapiens_hsa005900.76808027
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76080117
85Glioma_Homo sapiens_hsa052140.75261666
86Dorso-ventral axis formation_Homo sapiens_hsa043200.74887980
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72422110
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71830334
89beta-Alanine metabolism_Homo sapiens_hsa004100.71657996
90Allograft rejection_Homo sapiens_hsa053300.71329765
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68702540
92Graft-versus-host disease_Homo sapiens_hsa053320.66498149
93Pyruvate metabolism_Homo sapiens_hsa006200.66433009
94Basal cell carcinoma_Homo sapiens_hsa052170.66343227
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66318363
96Choline metabolism in cancer_Homo sapiens_hsa052310.64068123
97Autoimmune thyroid disease_Homo sapiens_hsa053200.64038647
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63990244
99Alzheimers disease_Homo sapiens_hsa050100.63909456
100Dilated cardiomyopathy_Homo sapiens_hsa054140.63831046
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.62698664
102Huntingtons disease_Homo sapiens_hsa050160.61456559
103Histidine metabolism_Homo sapiens_hsa003400.60627515
104One carbon pool by folate_Homo sapiens_hsa006700.60562546
105Regulation of autophagy_Homo sapiens_hsa041400.59760853
106Inositol phosphate metabolism_Homo sapiens_hsa005620.59706236
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59520356
108Oxidative phosphorylation_Homo sapiens_hsa001900.59237944
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58818501
110ErbB signaling pathway_Homo sapiens_hsa040120.57741007
111Purine metabolism_Homo sapiens_hsa002300.56277737
112Fat digestion and absorption_Homo sapiens_hsa049750.54966570
113Bile secretion_Homo sapiens_hsa049760.54293677
114Phototransduction_Homo sapiens_hsa047440.54252916
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52925511
116MAPK signaling pathway_Homo sapiens_hsa040100.52915775
117Systemic lupus erythematosus_Homo sapiens_hsa053220.51953568
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51438613
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50545608
120Non-homologous end-joining_Homo sapiens_hsa034500.47402647
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47110404
122Prion diseases_Homo sapiens_hsa050200.46305927
123VEGF signaling pathway_Homo sapiens_hsa043700.46230017
124Vitamin digestion and absorption_Homo sapiens_hsa049770.44806018
125Circadian rhythm_Homo sapiens_hsa047100.44210615
126Metabolic pathways_Homo sapiens_hsa011000.43546179
127Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42727719
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42365276
129Ras signaling pathway_Homo sapiens_hsa040140.40316877
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40260996
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40105667
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39886040
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39416245
134Hematopoietic cell lineage_Homo sapiens_hsa046400.38319920
135Rheumatoid arthritis_Homo sapiens_hsa053230.38117597
136African trypanosomiasis_Homo sapiens_hsa051430.37728851
137Glycerolipid metabolism_Homo sapiens_hsa005610.37412871
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.36242691
139Rap1 signaling pathway_Homo sapiens_hsa040150.36202441
140Hedgehog signaling pathway_Homo sapiens_hsa043400.35949712
141Mineral absorption_Homo sapiens_hsa049780.34695222
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34281314
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29833127
144Fatty acid biosynthesis_Homo sapiens_hsa000610.29585758
145Wnt signaling pathway_Homo sapiens_hsa043100.28457793
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27928777
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24782922
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23665683
149Propanoate metabolism_Homo sapiens_hsa006400.22098766
150Ovarian steroidogenesis_Homo sapiens_hsa049130.22050095
151Endocytosis_Homo sapiens_hsa041440.21930276
152Alcoholism_Homo sapiens_hsa050340.20127848
153Fructose and mannose metabolism_Homo sapiens_hsa000510.19982466
154Primary bile acid biosynthesis_Homo sapiens_hsa001200.19507441
155Pentose phosphate pathway_Homo sapiens_hsa000300.19282623
156Type I diabetes mellitus_Homo sapiens_hsa049400.19117967
157Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18377346
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15734016
159Neurotrophin signaling pathway_Homo sapiens_hsa047220.15115065

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