MASP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.46783106
2L-phenylalanine catabolic process (GO:0006559)7.46783106
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.08928056
4L-phenylalanine metabolic process (GO:0006558)7.08928056
5aromatic amino acid family catabolic process (GO:0009074)6.65425020
6negative regulation of fibrinolysis (GO:0051918)6.09187763
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.05428188
8tryptophan catabolic process (GO:0006569)5.93833209
9indole-containing compound catabolic process (GO:0042436)5.93833209
10indolalkylamine catabolic process (GO:0046218)5.93833209
11bile acid biosynthetic process (GO:0006699)5.93084313
12kynurenine metabolic process (GO:0070189)5.91111855
13glyoxylate metabolic process (GO:0046487)5.77939337
14regulation of fibrinolysis (GO:0051917)5.76676446
15alpha-linolenic acid metabolic process (GO:0036109)5.69828374
16tryptophan metabolic process (GO:0006568)5.58420719
17urea metabolic process (GO:0019627)5.50478045
18urea cycle (GO:0000050)5.50478045
19peptidyl-glutamic acid carboxylation (GO:0017187)5.43986230
20protein carboxylation (GO:0018214)5.43986230
21complement activation, alternative pathway (GO:0006957)5.43713410
22* regulation of protein activation cascade (GO:2000257)5.39133945
23high-density lipoprotein particle remodeling (GO:0034375)5.34012182
24sulfur amino acid catabolic process (GO:0000098)5.21794249
25cysteine metabolic process (GO:0006534)5.09790723
26bile acid metabolic process (GO:0008206)5.03852060
27nitrogen cycle metabolic process (GO:0071941)5.03667720
28* regulation of complement activation (GO:0030449)5.00890811
29serine family amino acid catabolic process (GO:0009071)4.86480607
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78056489
31aromatic amino acid family metabolic process (GO:0009072)4.77885742
32reverse cholesterol transport (GO:0043691)4.71949831
33tyrosine metabolic process (GO:0006570)4.70141313
34homocysteine metabolic process (GO:0050667)4.69291459
35regulation of triglyceride catabolic process (GO:0010896)4.62508203
36plasma lipoprotein particle remodeling (GO:0034369)4.59068574
37protein-lipid complex remodeling (GO:0034368)4.59068574
38macromolecular complex remodeling (GO:0034367)4.59068574
39lysine metabolic process (GO:0006553)4.54018089
40lysine catabolic process (GO:0006554)4.54018089
41regulation of cholesterol esterification (GO:0010872)4.53562273
42alpha-amino acid catabolic process (GO:1901606)4.51861568
43triglyceride homeostasis (GO:0070328)4.46141284
44acylglycerol homeostasis (GO:0055090)4.46141284
45cellular ketone body metabolic process (GO:0046950)4.44260802
46amino-acid betaine metabolic process (GO:0006577)4.43739523
47coenzyme catabolic process (GO:0009109)4.42650701
48plasma lipoprotein particle clearance (GO:0034381)4.34483400
49bile acid and bile salt transport (GO:0015721)4.33578352
50negative regulation of cholesterol transport (GO:0032375)4.29157859
51negative regulation of sterol transport (GO:0032372)4.29157859
52phospholipid efflux (GO:0033700)4.24303095
53glycine metabolic process (GO:0006544)4.23897012
54cellular glucuronidation (GO:0052695)4.22607876
55fibrinolysis (GO:0042730)4.22088820
56glutamate metabolic process (GO:0006536)4.18907043
57indolalkylamine metabolic process (GO:0006586)4.18019208
58cellular amino acid catabolic process (GO:0009063)4.15686696
59cholesterol efflux (GO:0033344)4.14159541
60imidazole-containing compound metabolic process (GO:0052803)4.12649368
61amine catabolic process (GO:0009310)4.07819337
62cellular biogenic amine catabolic process (GO:0042402)4.07819337
63cellular modified amino acid catabolic process (GO:0042219)4.06787641
64ethanol oxidation (GO:0006069)4.02157227
65serine family amino acid metabolic process (GO:0009069)4.01276606
66dicarboxylic acid biosynthetic process (GO:0043650)4.00996076
67benzene-containing compound metabolic process (GO:0042537)3.97623789
68serine family amino acid biosynthetic process (GO:0009070)3.97038198
69arginine metabolic process (GO:0006525)3.92541480
70aldehyde catabolic process (GO:0046185)3.88217187
71protein heterotrimerization (GO:0070208)3.84757415
72low-density lipoprotein particle remodeling (GO:0034374)3.84286041
73ketone body metabolic process (GO:1902224)3.83153489
74plasma lipoprotein particle assembly (GO:0034377)3.83063417
75cofactor catabolic process (GO:0051187)3.79433840
76blood coagulation, intrinsic pathway (GO:0007597)3.75950965
77phospholipid homeostasis (GO:0055091)3.75303865
78regulation of plasminogen activation (GO:0010755)3.75108061
79opsonization (GO:0008228)3.74404666
80positive regulation of lipid catabolic process (GO:0050996)3.73179057
81complement activation, classical pathway (GO:0006958)3.72949923
82uronic acid metabolic process (GO:0006063)3.72092212
83glucuronate metabolic process (GO:0019585)3.72092212
84extracellular matrix assembly (GO:0085029)3.71709376
85drug catabolic process (GO:0042737)3.70879687
86cholesterol homeostasis (GO:0042632)3.70108851
87acetyl-CoA metabolic process (GO:0006084)3.68717504
88positive regulation of fatty acid beta-oxidation (GO:0032000)3.67474353
89postsynaptic membrane organization (GO:0001941)3.66808252
90regulation of cholesterol homeostasis (GO:2000188)3.65091351
91sterol homeostasis (GO:0055092)3.64071822
92cytolysis (GO:0019835)3.63691924
93regulation of bile acid biosynthetic process (GO:0070857)3.63613392
94very-low-density lipoprotein particle assembly (GO:0034379)3.62171558
95organic acid catabolic process (GO:0016054)3.62012146
96carboxylic acid catabolic process (GO:0046395)3.62012146
97* protein activation cascade (GO:0072376)3.61036803
98positive regulation of lipoprotein lipase activity (GO:0051006)3.60257353
99positive regulation of triglyceride lipase activity (GO:0061365)3.60257353
100negative regulation of lipase activity (GO:0060192)3.58679945
101* complement activation (GO:0006956)3.57512003
102protein-lipid complex assembly (GO:0065005)3.56523879
103type B pancreatic cell proliferation (GO:0044342)3.56006219
104epoxygenase P450 pathway (GO:0019373)3.52626145
105pyrimidine nucleobase catabolic process (GO:0006208)3.41371943
106regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.39622663
107cell migration involved in heart development (GO:0060973)3.37044594
108negative regulation of protein localization to cell surface (GO:2000009)3.36573209
109endocardial cushion development (GO:0003197)3.26072010
110presynaptic membrane assembly (GO:0097105)3.24873249
111regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.23550303
112cardiac myofibril assembly (GO:0055003)3.21376732
113collagen fibril organization (GO:0030199)3.17406227
114presynaptic membrane organization (GO:0097090)3.07635757
115cGMP-mediated signaling (GO:0019934)3.06302307
116omega-hydroxylase P450 pathway (GO:0097267)3.06293285
117bone trabecula formation (GO:0060346)2.98238442
118positive regulation of synapse assembly (GO:0051965)2.89359095
119negative regulation of axon extension involved in axon guidance (GO:0048843)2.88354462
120dermatan sulfate biosynthetic process (GO:0030208)2.86902934
121exogenous drug catabolic process (GO:0042738)2.85200186
122mesenchymal-epithelial cell signaling (GO:0060638)2.81754692
123negative regulation of axon guidance (GO:1902668)2.75266622
124regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.73891162
125blood vessel maturation (GO:0001955)2.71876441
126dermatan sulfate metabolic process (GO:0030205)2.68643767
127pericardium development (GO:0060039)2.67051807
128nucleobase catabolic process (GO:0046113)2.62474038
129axonal fasciculation (GO:0007413)2.59002906
130retinal rod cell development (GO:0046548)2.55921139
131sequestering of extracellular ligand from receptor (GO:0035581)2.55524148
132tooth mineralization (GO:0034505)2.55262876
133L-serine metabolic process (GO:0006563)2.55033033
134glomerular basement membrane development (GO:0032836)2.52060208
135chondroitin sulfate catabolic process (GO:0030207)2.52030812
136astrocyte differentiation (GO:0048708)2.51379270
137midgut development (GO:0007494)2.50246487
138regulation of axon extension involved in axon guidance (GO:0048841)2.50180600
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.49423509
140regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.46740667
141regulation of axon guidance (GO:1902667)2.46203040
142negative regulation of astrocyte differentiation (GO:0048712)2.43895470
143myofibril assembly (GO:0030239)2.43584980
144drug metabolic process (GO:0017144)2.42710108
145virion attachment to host cell (GO:0019062)2.42343136
146adhesion of symbiont to host cell (GO:0044650)2.42343136
147axon extension involved in axon guidance (GO:0048846)2.42317219
148neuron projection extension involved in neuron projection guidance (GO:1902284)2.42317219
149response to magnesium ion (GO:0032026)2.41603391
150head development (GO:0060322)2.41073768
151cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.40563307
152positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.38427238
153positive regulation of gastrulation (GO:2000543)2.36713607
154regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.35725246
155venous blood vessel morphogenesis (GO:0048845)2.35188949
156peripheral nervous system neuron development (GO:0048935)2.34787271
157skin morphogenesis (GO:0043589)2.34640831
158mechanoreceptor differentiation (GO:0042490)2.32132327
159regulation of synapse assembly (GO:0051963)2.31803477
160positive regulation of smoothened signaling pathway (GO:0045880)2.31311677
161retinal ganglion cell axon guidance (GO:0031290)2.30759789
162alkaloid metabolic process (GO:0009820)2.29598426
163neuron recognition (GO:0008038)2.28627716
164retinal cone cell development (GO:0046549)2.27400914
165regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.26099922
166outer ear morphogenesis (GO:0042473)2.25922958
167xenobiotic catabolic process (GO:0042178)2.24326404
168calcium-mediated signaling using intracellular calcium source (GO:0035584)2.24239078
169positive regulation of cartilage development (GO:0061036)2.23960834
170regulation of the force of heart contraction (GO:0002026)2.22844523
171regulation of organ formation (GO:0003156)2.22248221
172negative regulation of leukocyte chemotaxis (GO:0002689)2.20712332
173cell proliferation involved in kidney development (GO:0072111)2.19075767
174cell communication by electrical coupling (GO:0010644)2.18929294
175positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.18621788
176positive regulation of male gonad development (GO:2000020)2.17099458
177embryonic forelimb morphogenesis (GO:0035115)2.16344343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.97567323
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.76481653
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.52217980
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.27902981
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.97643922
6EZH2_22144423_ChIP-Seq_EOC_Human4.68563241
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61328415
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.46977402
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01826095
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.57214234
11GBX2_23144817_ChIP-Seq_PC3_Human3.33465649
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.27793562
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07400464
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07257093
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05204451
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03106433
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01304361
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4165361
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92282642
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91058196
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90980919
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89932350
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89763448
24CLOCK_20551151_ChIP-Seq_293T_Human1.88067299
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.86403792
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85104813
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85104813
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79909928
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75419163
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.73975444
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.72108446
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71169254
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70093722
34TP53_18474530_ChIP-ChIP_U2OS_Human1.69483861
35TP53_16413492_ChIP-PET_HCT116_Human1.66057551
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65828615
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.65689416
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.61438309
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61367645
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59662057
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56068094
42HTT_18923047_ChIP-ChIP_STHdh_Human1.55911901
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52002935
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49797398
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49209437
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47122047
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45196172
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43293458
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.41247133
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40393860
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.37624640
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36498095
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33942574
54* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33589733
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29936105
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29482674
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29316489
58P300_19829295_ChIP-Seq_ESCs_Human1.29208932
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.25346113
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22547820
61DROSHA_22980978_ChIP-Seq_HELA_Human1.21608213
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20161390
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19719091
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18357515
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16806433
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16362211
67* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15068659
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14926196
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14282890
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.13558392
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13500538
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12211845
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11655734
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11655734
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11397616
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11287135
77TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11225600
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11077726
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09855982
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.08861612
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08304914
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.07661466
83AR_21572438_ChIP-Seq_LNCaP_Human1.07461626
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.07379603
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07334920
86STAT3_23295773_ChIP-Seq_U87_Human1.06565939
87RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05251693
88AR_25329375_ChIP-Seq_VCAP_Human1.05225416
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03918661
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03393965
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02612447
92ZNF274_21170338_ChIP-Seq_K562_Hela1.02565895
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01939798
94* ISL1_27105846_Chip-Seq_CPCs_Mouse1.01750199
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01078711
96* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00512448
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.98548248
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98494635
99* BRD4_25478319_ChIP-Seq_HGPS_Human0.97602689
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96883860
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96382828
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95540298
103EZH2_27294783_Chip-Seq_NPCs_Mouse0.95407749
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95225660
105* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93734244
106KDM2B_26808549_Chip-Seq_REH_Human0.93107953
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90350986
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.89279386
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88826942
110SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88099929
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86186371
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83613843
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82915861
114GATA1_22025678_ChIP-Seq_K562_Human0.81402474
115GATA4_25053715_ChIP-Seq_YYC3_Human0.76104571
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74747697
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.74309359
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.73896785
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.73605189
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72803252
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70647796
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66607166
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65317300
124ZNF263_19887448_ChIP-Seq_K562_Human0.64090564
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.61223473
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.60494634
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60313044
128* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59862043
129* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57795388
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.57528933
131* RARA_24833708_ChIP-Seq_LIVER_Mouse0.57491581
132TAF15_26573619_Chip-Seq_HEK293_Human0.57145888
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55791598
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55202374
135BCAT_22108803_ChIP-Seq_LS180_Human0.54420748
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.54059593
137* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53983159
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.53586378
139* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53566617
140CBP_21632823_ChIP-Seq_H3396_Human0.53020553
141* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.51499749
142SOX2_20726797_ChIP-Seq_SW620_Human0.50611372
143LXR_22292898_ChIP-Seq_THP-1_Human0.50390580
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.50168737
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.49970365
146KAP1_22055183_ChIP-Seq_ESCs_Mouse0.49316285
147MYC_19915707_ChIP-ChIP_AK7_Human0.49293385
148EGR1_19032775_ChIP-ChIP_M12_Human0.49210434
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.48737186
150CJUN_26792858_Chip-Seq_BT549_Human0.47496120
151CEBPB_22108803_ChIP-Seq_LS180_Human0.46736245
152ZNF217_24962896_ChIP-Seq_MCF-7_Human0.46298732
153NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.45595199
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.44363052
155TBX20_22080862_ChIP-Seq_HEART_Mouse0.44103454
156TBX20_22328084_ChIP-Seq_HEART_Mouse0.44103454
157EP300_21415370_ChIP-Seq_HL-1_Mouse0.42546894
158STAT1_17558387_ChIP-Seq_HELA_Human0.42471639
159PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42192231
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.41304678
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.41124696
162TP63_23658742_ChIP-Seq_EP156T_Human0.41071193
163NFIB_24661679_ChIP-Seq_LUNG_Mouse0.40760859
164FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.40565498
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40413520
166GATA1_19941826_ChIP-Seq_K562_Human0.39921964
167GATA2_19941826_ChIP-Seq_K562_Human0.39406878
168EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39348620
169MYC_27129775_Chip-Seq_CORNEA_Mouse0.39343124
170NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.38868353
171STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38596396
172PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.38338765
173SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38265594
174FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38227927
175P53_21459846_ChIP-Seq_SAOS-2_Human0.38214567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.12211784
2MP0005360_urolithiasis7.51411463
3MP0005085_abnormal_gallbladder_physiolo6.36632544
4MP0005365_abnormal_bile_salt6.00460085
5MP0008875_abnormal_xenobiotic_pharmacok4.91110591
6MP0003806_abnormal_nucleotide_metabolis4.20095975
7MP0003252_abnormal_bile_duct4.06510499
8MP0003136_yellow_coat_color3.97149518
9MP0010329_abnormal_lipoprotein_level3.49015029
10MP0001958_emphysema3.47218522
11MP0009840_abnormal_foam_cell3.13817856
12MP0004272_abnormal_basement_membrane3.11558920
13MP0005083_abnormal_biliary_tract3.10851334
14MP0006054_spinal_hemorrhage2.81917600
15MP0003195_calcinosis2.77710384
16MP0005332_abnormal_amino_acid2.61913596
17MP0002638_abnormal_pupillary_reflex2.45503866
18MP0001666_abnormal_nutrient_absorption2.44212933
19MP0005171_absent_coat_pigmentation2.37740388
20MP0005257_abnormal_intraocular_pressure2.23015338
21MP0000751_myopathy2.06066120
22MP0003191_abnormal_cellular_cholesterol2.05033001
23MP0000609_abnormal_liver_physiology2.04901758
24MP0002118_abnormal_lipid_homeostasis2.04449946
25MP0004858_abnormal_nervous_system2.00769355
26MP0003705_abnormal_hypodermis_morpholog1.94017061
27MP0004019_abnormal_vitamin_homeostasis1.89789857
28MP0003868_abnormal_feces_composition1.89300737
29MP0005508_abnormal_skeleton_morphology1.78909644
30MP0001542_abnormal_bone_strength1.77476665
31MP0005319_abnormal_enzyme/_coenzyme1.69657596
32MP0002138_abnormal_hepatobiliary_system1.61225602
33MP0009697_abnormal_copulation1.60254315
34MP0003942_abnormal_urinary_system1.56992275
35MP0002108_abnormal_muscle_morphology1.52609521
36MP0000049_abnormal_middle_ear1.52078224
37MP0008438_abnormal_cutaneous_collagen1.46786083
38MP0005584_abnormal_enzyme/coenzyme_acti1.44987031
39MP0001764_abnormal_homeostasis1.38096815
40MP0000778_abnormal_nervous_system1.37308155
41MP0000534_abnormal_ureter_morphology1.35872750
42MP0001529_abnormal_vocalization1.33832197
43MP0005451_abnormal_body_composition1.30099595
44MP0009780_abnormal_chondrocyte_physiolo1.26517242
45MP0001299_abnormal_eye_distance/1.25268835
46MP0003011_delayed_dark_adaptation1.24541569
47MP0010368_abnormal_lymphatic_system1.22925083
48MP0004859_abnormal_synaptic_plasticity1.22191874
49MP0009250_abnormal_appendicular_skeleto1.18330149
50MP0003656_abnormal_erythrocyte_physiolo1.16576176
51MP0000604_amyloidosis1.14397911
52MP0000598_abnormal_liver_morphology1.14019036
53MP0003880_abnormal_central_pattern1.11215891
54MP0005647_abnormal_sex_gland1.10450626
55MP0000013_abnormal_adipose_tissue1.08409380
56MP0003950_abnormal_plasma_membrane1.08213568
57MP0009643_abnormal_urine_homeostasis1.06269977
58MP0000767_abnormal_smooth_muscle1.05967385
59MP0003385_abnormal_body_wall1.05235372
60MP0004885_abnormal_endolymph1.03183892
61MP0003186_abnormal_redox_activity1.02559487
62MP0000538_abnormal_urinary_bladder1.01097307
63MP0000428_abnormal_craniofacial_morphol1.01038031
64MP0002254_reproductive_system_inflammat1.00314518
65MP0000026_abnormal_inner_ear0.98354652
66MP0002102_abnormal_ear_morphology0.98307033
67MP0004133_heterotaxia0.97867636
68MP0009384_cardiac_valve_regurgitation0.96061837
69MP0009053_abnormal_anal_canal0.95881059
70MP0004084_abnormal_cardiac_muscle0.95487059
71MP0004142_abnormal_muscle_tone0.95454682
72MP0009763_increased_sensitivity_to0.93818073
73MP0005408_hypopigmentation0.92394910
74MP0001984_abnormal_olfaction0.92068998
75MP0003755_abnormal_palate_morphology0.91755275
76MP0005551_abnormal_eye_electrophysiolog0.90982977
77MP0002736_abnormal_nociception_after0.88761613
78MP0002896_abnormal_bone_mineralization0.87414420
79MP0005620_abnormal_muscle_contractility0.86946621
80MP0009764_decreased_sensitivity_to0.85262266
81MP0002115_abnormal_skeleton_extremities0.84543410
82MP0005423_abnormal_somatic_nervous0.84496164
83MP0003937_abnormal_limbs/digits/tail_de0.82440748
84MP0000163_abnormal_cartilage_morphology0.82233776
85MP0003091_abnormal_cell_migration0.82020307
86MP0003115_abnormal_respiratory_system0.81305545
87MP0003329_amyloid_beta_deposits0.80853707
88MP0005220_abnormal_exocrine_pancreas0.80037221
89MP0000749_muscle_degeneration0.78838089
90MP0001502_abnormal_circadian_rhythm0.78072603
91MP0009642_abnormal_blood_homeostasis0.77281474
92MP0002837_dystrophic_cardiac_calcinosis0.77025989
93MP0003634_abnormal_glial_cell0.77012745
94MP0002653_abnormal_ependyma_morphology0.76797940
95MP0001661_extended_life_span0.75465383
96MP0005636_abnormal_mineral_homeostasis0.75208498
97MP0005084_abnormal_gallbladder_morpholo0.74455620
98MP0004215_abnormal_myocardial_fiber0.74185392
99MP0005376_homeostasis/metabolism_phenot0.73631448
100MP0004130_abnormal_muscle_cell0.72942373
101MP0010386_abnormal_urinary_bladder0.72807150
102MP0002116_abnormal_craniofacial_bone0.71970956
103MP0005670_abnormal_white_adipose0.71018657
104MP0002233_abnormal_nose_morphology0.70275339
105MP0002234_abnormal_pharynx_morphology0.68670173
106MP0002127_abnormal_cardiovascular_syste0.68613043
107MP0006276_abnormal_autonomic_nervous0.68594617
108MP0000955_abnormal_spinal_cord0.68183075
109MP0000639_abnormal_adrenal_gland0.67961096
110MP0002971_abnormal_brown_adipose0.67809068
111MP0002078_abnormal_glucose_homeostasis0.67706410
112MP0001963_abnormal_hearing_physiology0.67704822
113MP0004145_abnormal_muscle_electrophysio0.67174382
114MP0003690_abnormal_glial_cell0.66933793
115MP0008469_abnormal_protein_level0.66898413
116MP0005275_abnormal_skin_tensile0.66611909
117MP0000462_abnormal_digestive_system0.65651354
118MP0001270_distended_abdomen0.65613733
119MP0002876_abnormal_thyroid_physiology0.65338306
120MP0005197_abnormal_uvea_morphology0.64587136
121MP0005330_cardiomyopathy0.63655925
122MP0000566_synostosis0.63456577
123MP0000432_abnormal_head_morphology0.63351174
124MP0005334_abnormal_fat_pad0.61855806
125MP0003935_abnormal_craniofacial_develop0.61406936
126MP0009765_abnormal_xenobiotic_induced0.60156280
127MP0005395_other_phenotype0.57990928
128MP0002295_abnormal_pulmonary_circulatio0.56749379
129MP0005248_abnormal_Harderian_gland0.55945988
130MP0000579_abnormal_nail_morphology0.55810458
131MP0002060_abnormal_skin_morphology0.55598311
132MP0006036_abnormal_mitochondrial_physio0.55294266
133MP0001243_abnormal_dermal_layer0.54947905
134MP0002168_other_aberrant_phenotype0.53245570
135MP0005266_abnormal_metabolism0.52173184
136MP0005448_abnormal_energy_balance0.51375821
137MP0005535_abnormal_body_temperature0.50558978
138MP0005023_abnormal_wound_healing0.49222395
139MP0001756_abnormal_urination0.48722852
140MP0004883_abnormal_blood_vessel0.46105727
141MP0003279_aneurysm0.45795387
142MP0002928_abnormal_bile_duct0.45081843
143MP0005503_abnormal_tendon_morphology0.43114242
144MP0006035_abnormal_mitochondrial_morpho0.40221790
145MP0005187_abnormal_penis_morphology0.38332054
146MP0009672_abnormal_birth_weight0.37958555
147MP0005164_abnormal_response_to0.37640538
148MP0005666_abnormal_adipose_tissue0.37046151
149MP0003718_maternal_effect0.36254457
150MP0008874_decreased_physiological_sensi0.35890996
151MP0008873_increased_physiological_sensi0.34574713
152MP0005595_abnormal_vascular_smooth0.34348652
153MP0003638_abnormal_response/metabolism_0.34008821
154MP0000249_abnormal_blood_vessel0.33075321
155MP0002269_muscular_atrophy0.32119985
156MP0002282_abnormal_trachea_morphology0.30918045
157MP0003953_abnormal_hormone_level0.30744240
158MP0002136_abnormal_kidney_physiology0.30655409
159MP0005464_abnormal_platelet_physiology0.29650587
160MP0002796_impaired_skin_barrier0.29585324
161MP0002128_abnormal_blood_circulation0.28729597
162MP0003075_altered_response_to0.28695330
163MP0000230_abnormal_systemic_arterial0.28570387
164MP0002249_abnormal_larynx_morphology0.28149309
165MP0005166_decreased_susceptibility_to0.27471727
166MP0001881_abnormal_mammary_gland0.27395080
167MP0002090_abnormal_vision0.26954349

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.83886885
2Intrahepatic cholestasis (HP:0001406)7.45053663
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.15137302
4Prolonged partial thromboplastin time (HP:0003645)6.58726692
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.51139230
6Xanthomatosis (HP:0000991)6.35676045
7Hypobetalipoproteinemia (HP:0003563)6.30157349
8Complement deficiency (HP:0004431)5.53575179
9Hyperlipoproteinemia (HP:0010980)5.39357716
10Premature rupture of membranes (HP:0001788)5.35546159
11Hypolipoproteinemia (HP:0010981)4.79543001
12Follicular hyperkeratosis (HP:0007502)4.78406677
13Vascular tortuosity (HP:0004948)4.69616908
14Aortic aneurysm (HP:0004942)4.67466170
15Joint hemorrhage (HP:0005261)4.65218525
16Epidermoid cyst (HP:0200040)4.62057752
17Abnormality of the common coagulation pathway (HP:0010990)4.61842501
18Hyperammonemia (HP:0001987)4.43180131
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.36797445
20Hypoalphalipoproteinemia (HP:0003233)4.24147050
21Neonatal short-limb short stature (HP:0008921)4.23727532
22Hyperglycinemia (HP:0002154)4.16691928
23Abnormality of methionine metabolism (HP:0010901)4.11351274
24Fat malabsorption (HP:0002630)4.10154761
25Abnormality of sulfur amino acid metabolism (HP:0004339)4.09721808
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09187083
27Ankle contracture (HP:0006466)4.08048239
28Ketosis (HP:0001946)4.06037793
29Abnormality of complement system (HP:0005339)4.02257804
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.92841710
31Type 1 muscle fiber predominance (HP:0003803)3.92308890
32Aortic dissection (HP:0002647)3.91823239
33Broad metatarsal (HP:0001783)3.83839929
34Abnormality of the intrinsic pathway (HP:0010989)3.80483071
35Soft skin (HP:0000977)3.77392663
36Conjugated hyperbilirubinemia (HP:0002908)3.73761248
37Abnormality of glycine metabolism (HP:0010895)3.70815750
38Abnormality of serine family amino acid metabolism (HP:0010894)3.70815750
39Hypoglycemic coma (HP:0001325)3.60477395
40Hypercholesterolemia (HP:0003124)3.57027789
41Hyperglycinuria (HP:0003108)3.53417044
42Abnormality of dentin (HP:0010299)3.52793305
43Abnormality of pyrimidine metabolism (HP:0004353)3.46708874
44Bladder diverticulum (HP:0000015)3.43159194
45Hyperbilirubinemia (HP:0002904)3.22425482
46Skin nodule (HP:0200036)3.19372923
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.18135263
48Spontaneous abortion (HP:0005268)3.16997264
49Arterial tortuosity (HP:0005116)3.14574562
50Abnormality of fatty-acid metabolism (HP:0004359)3.12655424
51Myocardial infarction (HP:0001658)3.11356566
52Shallow orbits (HP:0000586)3.06067323
53Hepatocellular carcinoma (HP:0001402)3.04046779
54Steatorrhea (HP:0002570)3.00389809
55Abnormality of serum amino acid levels (HP:0003112)2.86533846
56Slender build (HP:0001533)2.86378140
57Delayed CNS myelination (HP:0002188)2.86325350
58Ketoacidosis (HP:0001993)2.81190241
59Hypochromic microcytic anemia (HP:0004840)2.79111417
60Abnormality of nucleobase metabolism (HP:0010932)2.77519230
61Mitral stenosis (HP:0001718)2.77175239
62Wormian bones (HP:0002645)2.75019152
63* Wide anterior fontanel (HP:0000260)2.73102033
64Systemic lupus erythematosus (HP:0002725)2.62314706
65Abnormal gallbladder morphology (HP:0012437)2.59751772
66Biconcave vertebral bodies (HP:0004586)2.56978355
67Aortic regurgitation (HP:0001659)2.55790736
68Vascular calcification (HP:0004934)2.55714570
69Acanthocytosis (HP:0001927)2.54917751
70Cholelithiasis (HP:0001081)2.53196711
71Spastic diplegia (HP:0001264)2.50877011
72Cardiovascular calcification (HP:0011915)2.50242694
73Metabolic acidosis (HP:0001942)2.50155065
74Mitral regurgitation (HP:0001653)2.44923030
75* Coronal craniosynostosis (HP:0004440)2.44899413
76Abnormal gallbladder physiology (HP:0012438)2.43984280
77Cholecystitis (HP:0001082)2.43984280
78Abnormality of purine metabolism (HP:0004352)2.42924408
79Spinal rigidity (HP:0003306)2.39578599
80Short 4th metacarpal (HP:0010044)2.36785837
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36785837
82Glomerulonephritis (HP:0000099)2.34883679
83Bowel diverticulosis (HP:0005222)2.34452195
84Atrophic scars (HP:0001075)2.32469287
85Polyphagia (HP:0002591)2.31469356
86Increased corneal curvature (HP:0100692)2.30744909
87Keratoconus (HP:0000563)2.30744909
88Lethargy (HP:0001254)2.30343553
89Neonatal onset (HP:0003623)2.28266763
90Hypoglycemic seizures (HP:0002173)2.27970418
91Dicarboxylic aciduria (HP:0003215)2.27801184
92Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27801184
93Amyloidosis (HP:0011034)2.25697437
94Septo-optic dysplasia (HP:0100842)2.25224611
95Calcaneovalgus deformity (HP:0001848)2.22232306
96Pulmonary artery stenosis (HP:0004415)2.20360703
97Abnormal delivery (HP:0001787)2.18389075
98Infantile muscular hypotonia (HP:0008947)2.18288998
99Irritability (HP:0000737)2.17527286
100Cervical subluxation (HP:0003308)2.17266794
101Gingival bleeding (HP:0000225)2.17170901
102Deformed tarsal bones (HP:0008119)2.16857726
103Cerebral edema (HP:0002181)2.16260464
104Hypoventilation (HP:0002791)2.14553708
105Menorrhagia (HP:0000132)2.14466029
106Peritonitis (HP:0002586)2.13182386
107Esophageal varix (HP:0002040)2.12731788
108Gout (HP:0001997)2.11868461
109Opisthotonus (HP:0002179)2.10428005
110Malnutrition (HP:0004395)2.10397337
111Abnormality of the gallbladder (HP:0005264)2.10010953
112Hemiparesis (HP:0001269)2.09310870
113Sensorimotor neuropathy (HP:0007141)2.07054919
114Aortic valve stenosis (HP:0001650)2.06793228
115Limited hip movement (HP:0008800)2.04057441
116Overgrowth (HP:0001548)2.03958797
117Abnormal cartilage morphology (HP:0002763)2.02971756
118Joint laxity (HP:0001388)2.02877978
119Enlarged kidneys (HP:0000105)2.01864569
120Hemorrhage of the eye (HP:0011885)2.01529214
121Hyperextensible skin (HP:0000974)2.00575672
122Synostosis involving bones of the feet (HP:0009140)1.98091569
123Synostosis involving bones of the lower limbs (HP:0009138)1.98091569
124Recurrent gram-negative bacterial infections (HP:0005420)1.97862453
125Hypophosphatemic rickets (HP:0004912)1.97595633
126Abnormality of the calf musculature (HP:0001430)1.97423078
127Increased variability in muscle fiber diameter (HP:0003557)1.96203352
128Breech presentation (HP:0001623)1.96199556
129Vertebral compression fractures (HP:0002953)1.94050480
130Thrombophlebitis (HP:0004418)1.93925771
131Occipital encephalocele (HP:0002085)1.93276192
132Partial duplication of the phalanx of hand (HP:0009999)1.92363656
133Tarsal synostosis (HP:0008368)1.90941897
134Morphological abnormality of the middle ear (HP:0008609)1.90732776
135Dilatation of the ascending aorta (HP:0005111)1.90636927
136Pancreatitis (HP:0001733)1.90440052
137Rickets (HP:0002748)1.90399430
138Wrist flexion contracture (HP:0001239)1.90119447
139Hip contracture (HP:0003273)1.89521870
140Lymphangioma (HP:0100764)1.89389888
141Brushfield spots (HP:0001088)1.87972489
142Hydroxyprolinuria (HP:0003080)1.87805702
143Abnormality of proline metabolism (HP:0010907)1.87805702
144Aneurysm (HP:0002617)1.87530767
145Abnormality of the 4th metacarpal (HP:0010012)1.87387089
146Poikilocytosis (HP:0004447)1.85175658
147Hyperinsulinemic hypoglycemia (HP:0000825)1.84863057
148Ulnar bowing (HP:0003031)1.84660749
149Blue sclerae (HP:0000592)1.84107381
150Mildly elevated creatine phosphokinase (HP:0008180)1.83896326
151Back pain (HP:0003418)1.83499803
152Vomiting (HP:0002013)1.82934446
153Long toe (HP:0010511)1.82152456
154Late onset (HP:0003584)1.81354522
155Protrusio acetabuli (HP:0003179)1.80120417
156Atelectasis (HP:0100750)1.79507274
157Abnormality of iron homeostasis (HP:0011031)1.78737031
158Turricephaly (HP:0000262)1.78375508
159Nephritis (HP:0000123)1.77952570
160Abnormal enzyme/coenzyme activity (HP:0012379)1.77181897
161Synostosis involving the elbow (HP:0003938)1.77112589
162Humeroradial synostosis (HP:0003041)1.77112589
163Hyperglycemia (HP:0003074)1.76741583
164Abnormality of the Achilles tendon (HP:0005109)1.73947839
165Genu recurvatum (HP:0002816)1.73854481
166Abnormality of transition element cation homeostasis (HP:0011030)1.73322507
167Camptodactyly of toe (HP:0001836)1.72779731
168Natal tooth (HP:0000695)1.72250926
169Mitral valve prolapse (HP:0001634)1.71495028
170Generalized aminoaciduria (HP:0002909)1.71017915
171Limb-girdle muscle weakness (HP:0003325)1.68696240
172Abnormality of the acetabulum (HP:0003170)1.68105184
173Atrial fibrillation (HP:0005110)1.67723521
174Broad ribs (HP:0000885)1.66515552
175Fragile skin (HP:0001030)1.66449101
176Ectopia lentis (HP:0001083)1.66289399
177Partial duplication of thumb phalanx (HP:0009944)1.64233848
178True hermaphroditism (HP:0010459)1.63803977
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.61575124
180Micromelia (HP:0002983)1.60540010
181Abnormality of the diencephalon (HP:0010662)1.59714058
182Inguinal hernia (HP:0000023)1.59700071
183Redundant skin (HP:0001582)1.58786194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.72139228
2SIK14.92082534
3FGFR43.96081211
4ERN13.87944511
5MARK13.31669377
6ERBB43.28485402
7NTRK23.20646149
8CASK3.02249154
9LATS12.77137205
10TRIB32.55647736
11PKN22.54075571
12INSRR2.45824450
13TAOK32.33635746
14FGFR22.08395898
15MAP2K41.98850343
16ADRBK21.98509899
17PIK3CG1.81766019
18GRK71.75793929
19GRK11.72166737
20TNIK1.72046566
21MST1R1.69941261
22DMPK1.69667188
23PTK61.64200944
24WNK41.63910788
25MAPK111.60542541
26ABL21.49958736
27NEK91.45421308
28PNCK1.44684717
29FLT31.44048538
30DDR21.41946885
31OBSCN1.41549171
32EPHB11.40881553
33PDGFRA1.37801260
34MAPK131.37461865
35MET1.35112145
36PAK61.33787973
37MAP3K101.31624159
38NTRK31.28839630
39AKT31.26941485
40LATS21.24789393
41FRK1.24495537
42ADRBK11.24252518
43PLK21.24251355
44DYRK21.22699285
45ERBB21.19120724
46EPHA31.17504157
47TTN1.16867218
48PAK31.16050539
49MAP4K21.15104666
50DAPK21.14777645
51MAPKAPK31.13440144
52STK38L1.10733611
53MAP3K71.10715931
54PRKD31.09536188
55EPHB21.05739037
56LIMK11.05721637
57ROCK21.03460592
58RIPK11.03457645
59PTK21.02114195
60WNK30.99033912
61TYK20.98343220
62KIT0.97654841
63PRKAA20.96372980
64CAMK2D0.94848449
65PDK20.93213781
66STK380.92763393
67PKN10.91536419
68PRKCZ0.91521374
69JAK10.91355426
70PRKD20.90112634
71JAK20.88040520
72KDR0.85265734
73PIK3CA0.84574388
74PRKCE0.83715065
75CDC42BPA0.83260376
76GRK50.82594322
77CAMK1D0.82100677
78MAPK40.81498328
79STK390.80273146
80CAMK2G0.80174746
81MOS0.79644783
82NUAK10.79520940
83TYRO30.79378413
84DYRK1B0.78718088
85PTK2B0.78125348
86MAPK120.77959191
87BCR0.76083979
88BMX0.74798958
89CAMK2B0.74306937
90GSK3A0.74064914
91ICK0.70823456
92CAMK2A0.70343091
93CSNK1G10.70075319
94CAMK10.70003448
95TGFBR20.68479591
96MTOR0.68302565
97CDK60.68268469
98PRKACG0.65592653
99PAK20.65072799
100RET0.63733176
101PRKAA10.63397268
102FGFR10.62513940
103MAP2K10.60808375
104MAP2K30.56532179
105STK30.55430632
106CDK50.54388002
107TBK10.53438292
108RPS6KA20.52764669
109BMPR1B0.52209404
110SGK30.50482268
111CSNK1A1L0.49698148
112MAPK70.49503431
113EPHA40.49172282
114CSNK1G20.49138337
115MAP3K40.48266159
116CAMK1G0.47859651
117ERBB30.46869438
118WNK10.46786490
119CSNK1G30.46530129
120PINK10.46456941
121PDPK10.46168744
122IGF1R0.46090630
123FGFR30.45768382
124CSF1R0.44532090
125PHKG10.44247012
126PHKG20.44247012
127PRKD10.43835735
128SGK2230.43319741
129SGK4940.43319741
130PIM20.42034305
131PRKCG0.41584096
132FER0.41392523
133PBK0.40994435
134PRKG10.40902512
135MAP3K30.40213078
136NTRK10.38357001
137PRKCH0.37857351
138MYLK0.37379713
139PRKACA0.37224830
140PRKCQ0.36200739
141TRPM70.35270920
142MAPK150.35010507
143MAP2K70.34169759
144INSR0.33895118
145ROCK10.33164751
146CSK0.32694542
147EGFR0.30876895
148PRKACB0.30162387
149CAMK40.28866274
150PDGFRB0.27094026
151TIE10.26560132
152SGK20.26331675
153TAOK20.25378235
154ABL10.24720093

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53380424
2Nitrogen metabolism_Homo sapiens_hsa009103.88130336
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40832979
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27219351
5Arginine biosynthesis_Homo sapiens_hsa002203.06428563
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.84379387
7* Complement and coagulation cascades_Homo sapiens_hsa046102.83394086
8Tryptophan metabolism_Homo sapiens_hsa003802.66647636
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62124588
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55960904
11Fatty acid degradation_Homo sapiens_hsa000712.48591895
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34925861
13Butanoate metabolism_Homo sapiens_hsa006502.21400347
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09776864
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06112093
16Peroxisome_Homo sapiens_hsa041461.99570192
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.94927693
18Chemical carcinogenesis_Homo sapiens_hsa052041.90220036
19Propanoate metabolism_Homo sapiens_hsa006401.89960241
20Fatty acid metabolism_Homo sapiens_hsa012121.87605704
21PPAR signaling pathway_Homo sapiens_hsa033201.87245940
22Histidine metabolism_Homo sapiens_hsa003401.87088584
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86458234
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79377697
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77318349
26Caffeine metabolism_Homo sapiens_hsa002321.70743367
27Retinol metabolism_Homo sapiens_hsa008301.64739410
28beta-Alanine metabolism_Homo sapiens_hsa004101.63790602
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.62469745
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56621382
31* Staphylococcus aureus infection_Homo sapiens_hsa051501.54858038
32Basal cell carcinoma_Homo sapiens_hsa052171.53474727
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52250126
34Phenylalanine metabolism_Homo sapiens_hsa003601.51110644
35Bile secretion_Homo sapiens_hsa049761.49655741
36Selenocompound metabolism_Homo sapiens_hsa004501.49499968
37Hedgehog signaling pathway_Homo sapiens_hsa043401.46045103
38Fatty acid elongation_Homo sapiens_hsa000621.43801180
39Tyrosine metabolism_Homo sapiens_hsa003501.40632635
40Steroid biosynthesis_Homo sapiens_hsa001001.40631500
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39919617
42Dilated cardiomyopathy_Homo sapiens_hsa054141.37413148
43Pyruvate metabolism_Homo sapiens_hsa006201.36768988
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36267705
45Sulfur metabolism_Homo sapiens_hsa009201.35682567
46Starch and sucrose metabolism_Homo sapiens_hsa005001.25651370
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.22653821
48Biosynthesis of amino acids_Homo sapiens_hsa012301.18552097
49ABC transporters_Homo sapiens_hsa020101.14241312
50Fat digestion and absorption_Homo sapiens_hsa049751.12214269
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11181299
52Carbon metabolism_Homo sapiens_hsa012001.10724841
53Folate biosynthesis_Homo sapiens_hsa007901.04035937
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03267522
55Vitamin B6 metabolism_Homo sapiens_hsa007501.01725848
56Arginine and proline metabolism_Homo sapiens_hsa003300.98097243
57Focal adhesion_Homo sapiens_hsa045100.95237635
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89236798
59Axon guidance_Homo sapiens_hsa043600.87603195
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.87008777
61Lysine degradation_Homo sapiens_hsa003100.85912739
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.84756880
63Vitamin digestion and absorption_Homo sapiens_hsa049770.83228307
64Sulfur relay system_Homo sapiens_hsa041220.82804092
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79410360
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76964602
67Hippo signaling pathway_Homo sapiens_hsa043900.75737584
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75106941
69Melanogenesis_Homo sapiens_hsa049160.71025578
70One carbon pool by folate_Homo sapiens_hsa006700.69690858
71Insulin secretion_Homo sapiens_hsa049110.68740796
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66343940
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65181815
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62692151
75Glutathione metabolism_Homo sapiens_hsa004800.60881424
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59770246
77Glycerolipid metabolism_Homo sapiens_hsa005610.59429879
78GABAergic synapse_Homo sapiens_hsa047270.58306808
79Cardiac muscle contraction_Homo sapiens_hsa042600.58193089
80Fatty acid biosynthesis_Homo sapiens_hsa000610.57155973
81Glutamatergic synapse_Homo sapiens_hsa047240.56634410
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.56252941
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56230455
84cAMP signaling pathway_Homo sapiens_hsa040240.55564131
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53182925
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52532358
87Circadian rhythm_Homo sapiens_hsa047100.51963907
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51858968
89Cocaine addiction_Homo sapiens_hsa050300.50330227
90Circadian entrainment_Homo sapiens_hsa047130.50262070
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47593661
92Calcium signaling pathway_Homo sapiens_hsa040200.46766326
93TGF-beta signaling pathway_Homo sapiens_hsa043500.45699782
94Prion diseases_Homo sapiens_hsa050200.43653270
95Pentose phosphate pathway_Homo sapiens_hsa000300.43612951
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42131247
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41763423
98Metabolic pathways_Homo sapiens_hsa011000.41029750
99Melanoma_Homo sapiens_hsa052180.39752765
100Nicotine addiction_Homo sapiens_hsa050330.39610515
101Gastric acid secretion_Homo sapiens_hsa049710.39079681
102Proteoglycans in cancer_Homo sapiens_hsa052050.36747193
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26202255
104Insulin resistance_Homo sapiens_hsa049310.24938034
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.24310375
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23149536
107Linoleic acid metabolism_Homo sapiens_hsa005910.20037868
108Galactose metabolism_Homo sapiens_hsa000520.16531876
109Glucagon signaling pathway_Homo sapiens_hsa049220.10870797
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10382938
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.10166525
112Fructose and mannose metabolism_Homo sapiens_hsa000510.08205155
113AMPK signaling pathway_Homo sapiens_hsa041520.06905051
114Ovarian steroidogenesis_Homo sapiens_hsa049130.04884756
115Ether lipid metabolism_Homo sapiens_hsa00565-0.2101056
116Protein digestion and absorption_Homo sapiens_hsa04974-0.2050131
117Hepatitis C_Homo sapiens_hsa05160-0.1991182
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1973891
119Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1944153
120Renin-angiotensin system_Homo sapiens_hsa04614-0.1926604
121Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1914261
122Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1829451
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1693236
124Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1666430
125Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1652266
126ECM-receptor interaction_Homo sapiens_hsa04512-0.1428751
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1250987
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1195977
129Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1037632
130Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1027759
131Bladder cancer_Homo sapiens_hsa05219-0.0846326
132Amoebiasis_Homo sapiens_hsa05146-0.0691140
133Insulin signaling pathway_Homo sapiens_hsa04910-0.0615830

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