MAST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.63923666
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.42796737
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.98495302
4locomotory exploration behavior (GO:0035641)5.82191919
5vocalization behavior (GO:0071625)5.45725593
6glutamate secretion (GO:0014047)5.44469709
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.40385741
8synaptic vesicle exocytosis (GO:0016079)5.38757993
9regulation of synaptic vesicle exocytosis (GO:2000300)5.35617379
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16093002
11layer formation in cerebral cortex (GO:0021819)4.97848448
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.95912719
13protein localization to synapse (GO:0035418)4.86363053
14regulation of synaptic vesicle transport (GO:1902803)4.77783556
15regulation of glutamate receptor signaling pathway (GO:1900449)4.73338123
16response to pheromone (GO:0019236)4.68491289
17neurotransmitter secretion (GO:0007269)4.66594390
18exploration behavior (GO:0035640)4.64357025
19neuron cell-cell adhesion (GO:0007158)4.61720210
20proline transport (GO:0015824)4.49630491
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.48985296
22gamma-aminobutyric acid transport (GO:0015812)4.36323737
23cellular potassium ion homeostasis (GO:0030007)4.29247214
24regulation of neuronal synaptic plasticity (GO:0048168)4.24269625
25neuronal action potential propagation (GO:0019227)4.17692747
26cerebellar Purkinje cell differentiation (GO:0021702)4.17579987
27cell migration in hindbrain (GO:0021535)4.12803680
28synaptic transmission, glutamatergic (GO:0035249)4.11779713
29sodium ion export (GO:0071436)4.07913440
30regulation of synapse structural plasticity (GO:0051823)4.06925134
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.05739897
32dendritic spine morphogenesis (GO:0060997)4.04015148
33dendrite morphogenesis (GO:0048813)3.90640463
34glutamate receptor signaling pathway (GO:0007215)3.89444423
35positive regulation of synapse maturation (GO:0090129)3.89075504
36behavioral response to nicotine (GO:0035095)3.86160064
37presynaptic membrane assembly (GO:0097105)3.84577752
38presynaptic membrane organization (GO:0097090)3.78797676
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.78588237
40glycine transport (GO:0015816)3.76996812
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.76688457
42neurotransmitter-gated ion channel clustering (GO:0072578)3.75544361
43synaptic vesicle endocytosis (GO:0048488)3.75042194
44neurotransmitter transport (GO:0006836)3.74248544
45establishment of mitochondrion localization (GO:0051654)3.74054993
46neuron recognition (GO:0008038)3.72411584
47cell communication by electrical coupling (GO:0010644)3.70038304
48postsynaptic membrane organization (GO:0001941)3.67542532
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.66586951
50neuron-neuron synaptic transmission (GO:0007270)3.66200030
51neuromuscular process controlling posture (GO:0050884)3.63819738
52axon ensheathment in central nervous system (GO:0032291)3.62678217
53central nervous system myelination (GO:0022010)3.62678217
54positive regulation of membrane potential (GO:0045838)3.60359655
55long-term memory (GO:0007616)3.59717727
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.59218647
57pyrimidine nucleobase catabolic process (GO:0006208)3.58994398
58activation of protein kinase A activity (GO:0034199)3.58679404
59neuromuscular process controlling balance (GO:0050885)3.58325829
60nucleobase catabolic process (GO:0046113)3.56971501
61axonal fasciculation (GO:0007413)3.56229748
62regulation of neurotransmitter secretion (GO:0046928)3.54232311
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45766982
64mechanosensory behavior (GO:0007638)3.44950741
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.44661177
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.44498646
67membrane depolarization during action potential (GO:0086010)3.42686620
68regulation of neurotransmitter levels (GO:0001505)3.40617491
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39511290
70axon cargo transport (GO:0008088)3.38952845
71central nervous system projection neuron axonogenesis (GO:0021952)3.36002427
72negative regulation of microtubule polymerization (GO:0031115)3.34438243
73response to auditory stimulus (GO:0010996)3.33092669
74auditory behavior (GO:0031223)3.32150558
75transmission of nerve impulse (GO:0019226)3.31840573
76regulation of postsynaptic membrane potential (GO:0060078)3.31344843
77cerebellar granule cell differentiation (GO:0021707)3.27616918
78regulation of voltage-gated calcium channel activity (GO:1901385)3.26623565
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24518801
80positive regulation of dendritic spine morphogenesis (GO:0061003)3.23662435
81potassium ion import (GO:0010107)3.22364031
82innervation (GO:0060384)3.22214387
83regulation of synaptic plasticity (GO:0048167)3.19417351
84adult walking behavior (GO:0007628)3.18961748
85regulation of vesicle fusion (GO:0031338)3.16650067
86regulation of neurotransmitter transport (GO:0051588)3.16452301
87L-amino acid import (GO:0043092)3.16084190
88synapse assembly (GO:0007416)3.15340923
89organelle transport along microtubule (GO:0072384)3.14961203
90regulation of synapse maturation (GO:0090128)3.12743843
91membrane hyperpolarization (GO:0060081)3.11809789
92vesicle transport along microtubule (GO:0047496)3.11173042
93positive regulation of neurotransmitter transport (GO:0051590)3.10872651
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09464038
95synaptic transmission (GO:0007268)3.09461865
96regulation of ARF protein signal transduction (GO:0032012)3.09404374
97dendritic spine organization (GO:0097061)3.09120589
98mitochondrion transport along microtubule (GO:0047497)3.08239272
99establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.08239272
100positive regulation of potassium ion transmembrane transport (GO:1901381)3.08020858
101neuromuscular process (GO:0050905)3.07262900
102membrane depolarization (GO:0051899)3.07065610
103cerebellar Purkinje cell layer development (GO:0021680)3.06364381
104cell differentiation in hindbrain (GO:0021533)3.04872289
105startle response (GO:0001964)3.03713311
106social behavior (GO:0035176)3.02671732
107intraspecies interaction between organisms (GO:0051703)3.02671732
108neuronal ion channel clustering (GO:0045161)3.00064359
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98657825
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98509952
111negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97954777
112regulation of synaptic transmission, glutamatergic (GO:0051966)2.97898035
113gamma-aminobutyric acid signaling pathway (GO:0007214)2.96828609
114positive regulation of synapse assembly (GO:0051965)2.96021013
115regulation of dendritic spine development (GO:0060998)2.95902563
116potassium ion homeostasis (GO:0055075)2.93436183
117establishment of nucleus localization (GO:0040023)2.93045248
118regulation of dendritic spine morphogenesis (GO:0061001)2.92059222
119regulation of calcium ion-dependent exocytosis (GO:0017158)2.91402678
120positive regulation of dendritic spine development (GO:0060999)2.91260448
121neuromuscular synaptic transmission (GO:0007274)2.90772061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22759706
2GBX2_23144817_ChIP-Seq_PC3_Human3.24924374
3REST_21632747_ChIP-Seq_MESCs_Mouse3.01121454
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99357465
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96096758
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90142391
7DROSHA_22980978_ChIP-Seq_HELA_Human2.74949705
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72118129
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72118129
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61730413
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.59746937
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53016986
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45683413
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.45581263
15* REST_18959480_ChIP-ChIP_MESCs_Mouse2.45131440
16* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44787929
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42581298
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.41252357
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40085548
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.36524141
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28922561
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25251414
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23092449
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.23091397
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20775166
26* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15424979
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.12101593
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05595252
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98957545
30AR_21572438_ChIP-Seq_LNCaP_Human1.66239997
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64802299
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.62075325
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52300652
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51164079
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50378609
36ZNF274_21170338_ChIP-Seq_K562_Hela1.47667755
37SMAD4_21799915_ChIP-Seq_A2780_Human1.47017946
38KDM2B_26808549_Chip-Seq_K562_Human1.40397257
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.37287364
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37169275
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36838746
42* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33430228
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32789874
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27590111
45AR_19668381_ChIP-Seq_PC3_Human1.27581082
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.26603813
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24323397
48IGF1R_20145208_ChIP-Seq_DFB_Human1.23200949
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.23128752
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22955439
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21411608
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21404508
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19625442
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18381238
55STAT3_23295773_ChIP-Seq_U87_Human1.18367586
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17644319
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17190069
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15617178
59TAF15_26573619_Chip-Seq_HEK293_Human1.14042509
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13017598
61* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12898761
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.11475214
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.10816718
64RNF2_27304074_Chip-Seq_NSC_Mouse1.10754916
65* AR_25329375_ChIP-Seq_VCAP_Human1.10319760
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10055335
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09942309
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09134012
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08677671
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.08237971
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07086932
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06886720
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05852018
74P300_19829295_ChIP-Seq_ESCs_Human1.05065672
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03071250
76VDR_22108803_ChIP-Seq_LS180_Human1.01987430
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01442598
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.01302197
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.01288795
80SMAD3_21741376_ChIP-Seq_ESCs_Human1.01264704
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00997100
82SMAD4_21741376_ChIP-Seq_HESCs_Human0.98802016
83AHR_22903824_ChIP-Seq_MCF-7_Human0.98384339
84* TCF4_23295773_ChIP-Seq_U87_Human0.97403052
85* OCT4_19829295_ChIP-Seq_ESCs_Human0.97322343
86ARNT_22903824_ChIP-Seq_MCF-7_Human0.96108131
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95832981
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95297498
89* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94313568
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93621214
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93259957
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92831321
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92367710
94CTCF_27219007_Chip-Seq_Bcells_Human0.92313859
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.91505155
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90536489
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88255637
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87319535
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87319535
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86835779
101CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86043778
102CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85690610
103KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84840956
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84683832
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84456218
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84145096
107* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84010400
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83804555
109RUNX2_22187159_ChIP-Seq_PCA_Human0.83624807
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82472571
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.82397518
112* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80754667
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79873307
114NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78017923
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77134872
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76969866
117ERA_21632823_ChIP-Seq_H3396_Human0.74234835
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73439191
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73048681
120DPY_21335234_ChIP-Seq_ESCs_Mouse0.73006808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.30589005
2MP0003880_abnormal_central_pattern4.14411651
3MP0003635_abnormal_synaptic_transmissio4.01686393
4MP0004270_analgesia3.95894795
5MP0005423_abnormal_somatic_nervous3.64125913
6MP0001968_abnormal_touch/_nociception3.29364172
7MP0009046_muscle_twitch3.21211451
8MP0002063_abnormal_learning/memory/cond3.13783367
9MP0002735_abnormal_chemical_nociception3.05540161
10MP0009745_abnormal_behavioral_response3.03780393
11MP0002734_abnormal_mechanical_nocicepti3.03716360
12MP0002064_seizures2.89300567
13MP0002572_abnormal_emotion/affect_behav2.57206395
14MP0002733_abnormal_thermal_nociception2.48168005
15MP0002736_abnormal_nociception_after2.47237237
16MP0002272_abnormal_nervous_system2.46040680
17MP0004858_abnormal_nervous_system2.45686691
18MP0001486_abnormal_startle_reflex2.39287738
19MP0006276_abnormal_autonomic_nervous2.32379472
20MP0002184_abnormal_innervation2.25401523
21MP0000778_abnormal_nervous_system2.21979655
22MP0001970_abnormal_pain_threshold2.21841079
23MP0002067_abnormal_sensory_capabilities2.07787881
24MP0004811_abnormal_neuron_physiology2.04127397
25MP0001440_abnormal_grooming_behavior2.01422719
26MP0008569_lethality_at_weaning2.00628698
27MP0001501_abnormal_sleep_pattern1.97620821
28MP0005645_abnormal_hypothalamus_physiol1.86401921
29MP0002557_abnormal_social/conspecific_i1.85493963
30MP0000569_abnormal_digit_pigmentation1.83717025
31MP0000955_abnormal_spinal_cord1.83028401
32MP0003329_amyloid_beta_deposits1.81127711
33MP0009780_abnormal_chondrocyte_physiolo1.76107841
34MP0003787_abnormal_imprinting1.74199320
35MP0002909_abnormal_adrenal_gland1.70498296
36MP0004924_abnormal_behavior1.66357741
37MP0005386_behavior/neurological_phenoty1.66357741
38MP0004885_abnormal_endolymph1.64043308
39MP0001984_abnormal_olfaction1.62085764
40MP0002882_abnormal_neuron_morphology1.60420330
41MP0003879_abnormal_hair_cell1.48483460
42MP0005646_abnormal_pituitary_gland1.45754995
43MP0002066_abnormal_motor_capabilities/c1.45099926
44MP0001502_abnormal_circadian_rhythm1.42905801
45MP0008877_abnormal_DNA_methylation1.39468483
46MP0003122_maternal_imprinting1.38325396
47MP0003633_abnormal_nervous_system1.26921371
48MP0004142_abnormal_muscle_tone1.26011749
49MP0002152_abnormal_brain_morphology1.22235213
50MP0003283_abnormal_digestive_organ1.18041199
51MP0002229_neurodegeneration1.12893894
52MP0010386_abnormal_urinary_bladder1.11856556
53MP0003631_nervous_system_phenotype1.09900516
54MP0002822_catalepsy1.06957267
55MP0001485_abnormal_pinna_reflex1.06690836
56MP0005551_abnormal_eye_electrophysiolog1.06669652
57MP0005499_abnormal_olfactory_system1.04984006
58MP0005394_taste/olfaction_phenotype1.04984006
59MP0004147_increased_porphyrin_level1.04499825
60MP0002638_abnormal_pupillary_reflex1.02769338
61MP0004145_abnormal_muscle_electrophysio1.00824610
62MP0003123_paternal_imprinting1.00582637
63MP0004133_heterotaxia0.98923534
64MP0001348_abnormal_lacrimal_gland0.98284720
65MP0008961_abnormal_basal_metabolism0.98019364
66MP0002102_abnormal_ear_morphology0.97663625
67MP0002752_abnormal_somatic_nervous0.95178993
68MP0004742_abnormal_vestibular_system0.94748443
69MP0002069_abnormal_eating/drinking_beha0.91712160
70MP0003634_abnormal_glial_cell0.88977402
71MP0003632_abnormal_nervous_system0.86017336
72MP0006292_abnormal_olfactory_placode0.83469253
73MP0002876_abnormal_thyroid_physiology0.83165667
74MP0001188_hyperpigmentation0.82786797
75MP0000026_abnormal_inner_ear0.81595566
76MP0001905_abnormal_dopamine_level0.81539650
77MP0003136_yellow_coat_color0.80875823
78MP0008872_abnormal_physiological_respon0.80802382
79MP0003172_abnormal_lysosome_physiology0.80606308
80MP0000631_abnormal_neuroendocrine_gland0.80504925
81MP0001963_abnormal_hearing_physiology0.78871725
82MP0003861_abnormal_nervous_system0.77538465
83MP0001177_atelectasis0.77142862
84MP0000604_amyloidosis0.72893463
85MP0001299_abnormal_eye_distance/0.72670979
86MP0000751_myopathy0.72374122
87MP0003938_abnormal_ear_development0.71863303
88MP0003119_abnormal_digestive_system0.71035784
89MP0005167_abnormal_blood-brain_barrier0.70835366
90MP0001986_abnormal_taste_sensitivity0.69815893
91MP0004085_abnormal_heartbeat0.69475043
92MP0004043_abnormal_pH_regulation0.68251926
93MP0008874_decreased_physiological_sensi0.66899081
94MP0001529_abnormal_vocalization0.65818403
95MP0003137_abnormal_impulse_conducting0.65791369
96MP0006072_abnormal_retinal_apoptosis0.65781465
97MP0003690_abnormal_glial_cell0.65737094
98MP0005187_abnormal_penis_morphology0.64971749
99MP0002653_abnormal_ependyma_morphology0.64805171
100MP0004233_abnormal_muscle_weight0.63872951
101MP0005535_abnormal_body_temperature0.63864759
102MP0004130_abnormal_muscle_cell0.63386519
103MP0002751_abnormal_autonomic_nervous0.62762390
104MP0010769_abnormal_survival0.62461334
105MP0000920_abnormal_myelination0.61043182
106MP0002082_postnatal_lethality0.60460280
107MP0010770_preweaning_lethality0.60460280
108MP0001346_abnormal_lacrimal_gland0.60388273
109MP0005253_abnormal_eye_physiology0.60380283
110MP0002249_abnormal_larynx_morphology0.59883690
111MP0010768_mortality/aging0.58872824
112MP0001943_abnormal_respiration0.55295423
113MP0003121_genomic_imprinting0.54447871
114MP0000013_abnormal_adipose_tissue0.52800552
115MP0003956_abnormal_body_size0.51465664
116MP0002089_abnormal_postnatal_growth/wei0.50178753
117MP0003075_altered_response_to0.49645028

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.11645933
2Focal motor seizures (HP:0011153)5.78451992
3Focal seizures (HP:0007359)5.15988100
4Visual hallucinations (HP:0002367)5.11013431
5Progressive cerebellar ataxia (HP:0002073)4.71896792
6Action tremor (HP:0002345)4.64730081
7Supranuclear gaze palsy (HP:0000605)4.37713763
8Epileptic encephalopathy (HP:0200134)4.36567404
9Febrile seizures (HP:0002373)4.22423483
10Mutism (HP:0002300)4.01136199
11Ankle clonus (HP:0011448)3.88471211
12Atonic seizures (HP:0010819)3.77423248
13Absence seizures (HP:0002121)3.48776809
14Generalized tonic-clonic seizures (HP:0002069)3.37880542
15Genetic anticipation (HP:0003743)3.33530058
16Poor eye contact (HP:0000817)3.29575886
17Papilledema (HP:0001085)3.26001596
18Urinary bladder sphincter dysfunction (HP:0002839)3.24731486
19Depression (HP:0000716)3.22953993
20Abnormality of the lower motor neuron (HP:0002366)3.17872513
21Broad-based gait (HP:0002136)3.13848262
22Dialeptic seizures (HP:0011146)3.10473200
23Gaze-evoked nystagmus (HP:0000640)3.09812842
24Truncal ataxia (HP:0002078)3.00754878
25Impaired social interactions (HP:0000735)2.98364203
26Abnormal social behavior (HP:0012433)2.98364203
27Abnormal eating behavior (HP:0100738)2.95950515
28Postural instability (HP:0002172)2.95908238
29Abnormality of the corticospinal tract (HP:0002492)2.95145346
30Impaired vibration sensation in the lower limbs (HP:0002166)2.88778469
31Excessive salivation (HP:0003781)2.82863040
32Drooling (HP:0002307)2.82863040
33Dysdiadochokinesis (HP:0002075)2.81346139
34Urinary urgency (HP:0000012)2.78380853
35Hemiparesis (HP:0001269)2.78218892
36Insomnia (HP:0100785)2.76628375
37Spastic gait (HP:0002064)2.72487869
38Amyotrophic lateral sclerosis (HP:0007354)2.71718850
39Impaired smooth pursuit (HP:0007772)2.71561308
40Limb dystonia (HP:0002451)2.70055974
41Dysmetria (HP:0001310)2.63961639
42Torticollis (HP:0000473)2.61496945
43Agitation (HP:0000713)2.60349109
44Ventricular fibrillation (HP:0001663)2.58072673
45Hemiplegia (HP:0002301)2.56193981
46Cerebral hypomyelination (HP:0006808)2.55807722
47Anxiety (HP:0000739)2.55498991
48Abnormality of ocular smooth pursuit (HP:0000617)2.53897587
49Insidious onset (HP:0003587)2.49722381
50Termporal pattern (HP:0011008)2.49722381
51Diplopia (HP:0000651)2.49370892
52Abnormality of binocular vision (HP:0011514)2.49370892
53Amblyopia (HP:0000646)2.46041440
54Progressive inability to walk (HP:0002505)2.45608457
55Polyphagia (HP:0002591)2.44239995
56Pheochromocytoma (HP:0002666)2.42499974
57Scanning speech (HP:0002168)2.36787083
58EEG with generalized epileptiform discharges (HP:0011198)2.36586284
59Bradykinesia (HP:0002067)2.36301824
60Intention tremor (HP:0002080)2.35877056
61Epileptiform EEG discharges (HP:0011182)2.34775835
62Lower limb muscle weakness (HP:0007340)2.34347280
63Gait imbalance (HP:0002141)2.33858659
64Fetal akinesia sequence (HP:0001989)2.33297395
65Annular pancreas (HP:0001734)2.33212758
66Focal dystonia (HP:0004373)2.30546594
67Hypsarrhythmia (HP:0002521)2.28381086
68Type II lissencephaly (HP:0007260)2.25799136
69Stereotypic behavior (HP:0000733)2.24061340
70Inappropriate behavior (HP:0000719)2.22977582
71Obstructive sleep apnea (HP:0002870)2.22739270
72Pointed chin (HP:0000307)2.21471134
73Retinal dysplasia (HP:0007973)2.19680266
74Lissencephaly (HP:0001339)2.15295556
75Akinesia (HP:0002304)2.14682819
76Failure to thrive in infancy (HP:0001531)2.14439498
77Absent speech (HP:0001344)2.12472779
78Spastic tetraparesis (HP:0001285)2.12001607
79Aqueductal stenosis (HP:0002410)2.10868454
80Dysmetric saccades (HP:0000641)2.10679207
81Hyperacusis (HP:0010780)2.10538004
82Morphological abnormality of the pyramidal tract (HP:0002062)2.10019038
83Megalencephaly (HP:0001355)2.09728994
84Clonus (HP:0002169)2.09565754
85Hypoplasia of the brainstem (HP:0002365)2.08267753
86Aplasia/Hypoplasia of the brainstem (HP:0007362)2.08267753
87Hyperventilation (HP:0002883)2.08251848
88Congenital stationary night blindness (HP:0007642)2.07752482
89Apathy (HP:0000741)2.07234635
90Craniofacial dystonia (HP:0012179)2.06341412
91Spastic tetraplegia (HP:0002510)2.06266751
92CNS hypomyelination (HP:0003429)2.04674372
93Elfin facies (HP:0004428)2.02178749
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02108868
95Inability to walk (HP:0002540)1.99354825
96Neurofibrillary tangles (HP:0002185)1.99271723
97Status epilepticus (HP:0002133)1.97990793
98Neuroendocrine neoplasm (HP:0100634)1.97312372
99Impaired vibratory sensation (HP:0002495)1.96597973
100Ulnar claw (HP:0001178)1.96218793
101Nephronophthisis (HP:0000090)1.95980380
102Abnormality of the labia minora (HP:0012880)1.95344291
103Sleep apnea (HP:0010535)1.94527936
104Delusions (HP:0000746)1.89722072
105Molar tooth sign on MRI (HP:0002419)1.89206707
106Abnormality of midbrain morphology (HP:0002418)1.89206707
107Bundle branch block (HP:0011710)1.85263457
108Abnormality of salivation (HP:0100755)1.85051420
109Pachygyria (HP:0001302)1.83650401
110Tetraplegia (HP:0002445)1.83568208
111Cerebral inclusion bodies (HP:0100314)1.83510895
112Specific learning disability (HP:0001328)1.83293099
113Paraplegia (HP:0010550)1.83241473
114Hypoplasia of the corpus callosum (HP:0002079)1.81961715
115Spastic paraplegia (HP:0001258)1.81814039
116Gait ataxia (HP:0002066)1.81411322
117Protruding tongue (HP:0010808)1.81372714
118Diminished motivation (HP:0000745)1.80891562
119True hermaphroditism (HP:0010459)1.78937454
120Decreased central vision (HP:0007663)1.77116983
121Pancreatic cysts (HP:0001737)1.76330297
122Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75177859
123Degeneration of the lateral corticospinal tracts (HP:0002314)1.75177859
124Incomplete penetrance (HP:0003829)1.73550949
125Pancreatic fibrosis (HP:0100732)1.72997943
126Oligodactyly (hands) (HP:0001180)1.72157415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.21151623
2MAP3K94.29731571
3NTRK34.11372594
4MINK13.23120003
5MAP3K43.21166737
6MAP2K72.76314055
7PAK62.64335410
8NTRK22.37958551
9DAPK22.26042152
10EPHA42.07389141
11MAP2K41.97650392
12CAMKK11.95480074
13NTRK11.91284571
14LATS21.89464776
15PRKD31.85346318
16MAPK131.77959441
17PHKG11.74947695
18PHKG21.74947695
19STK381.63398662
20KSR21.59323006
21MAP3K121.57663455
22CDK51.53112842
23SIK21.49664622
24KSR11.47439090
25WNK41.38870652
26INSRR1.35971024
27TNIK1.32820364
28MAP4K21.28705859
29LMTK21.25159875
30UHMK11.23871445
31FRK1.23300935
32CASK1.21812336
33PRKCG1.21661301
34GRK51.18004585
35PNCK1.15122109
36ADRBK21.14786956
37PRPF4B1.13321015
38TAOK11.12495059
39PLK21.12044672
40CAMKK21.10480451
41DAPK11.09437001
42ALK1.08736931
43CDK191.06269575
44SGK4941.01098687
45SGK2231.01098687
46RET0.98551953
47MAP3K20.94673565
48PRKCH0.94565898
49OXSR10.93660361
50ERBB30.93384573
51TYRO30.92503034
52STK110.92128567
53BMPR1B0.91721437
54CDK180.90478532
55SGK20.87567696
56CDK150.87311379
57CSNK1G20.87027276
58CAMK10.86178468
59RIPK40.85026666
60PINK10.84275141
61SGK30.84065542
62CDK140.83769325
63DYRK20.83033360
64BCR0.81716359
65DYRK1A0.80389013
66RIPK10.79560836
67TLK10.79012432
68CAMK1G0.78456225
69MARK20.77792225
70PAK30.77341552
71FGFR20.76886842
72CDK11A0.75829256
73CAMK2A0.69888043
74RPS6KA20.68364251
75SCYL20.68348324
76FES0.68154517
77CDC42BPA0.65775575
78PRKCZ0.65338986
79ICK0.62477621
80WNK10.62303490
81LIMK10.62044977
82GRK10.61871381
83BRSK10.59430681
84SIK30.58498172
85SGK10.57546856
86NEK10.53913770
87MAP2K60.53319858
88RPS6KA30.50823879
89CAMK2G0.47852819
90CAMK40.47828609
91MAPK100.47743908
92TRIM280.47571363
93MAPK120.46676545
94NEK60.46089175
95ADRBK10.44992035
96PDK10.44830016
97TNK20.44781910
98MAPKAPK50.44483860
99CSNK1G10.43019208
100FYN0.41943707
101PRKCE0.40571796
102ARAF0.39852399
103CAMK1D0.38426993
104WNK30.37931928
105MAP3K60.37553283
106CAMK2B0.37500442
107PRKACA0.37075695
108MAPK80.36873896
109CSNK1D0.36519304
110PRKAA10.35587927
111PRKCA0.34499989
112CSNK1G30.33879916
113PDPK10.33683819
114STK390.33468709
115MAP3K10.33380138
116PKN10.33263169
117CAMK2D0.33223025
118ERBB20.33120718
119PRKCB0.32720850
120CSNK1A1L0.32427461
121CSNK1A10.31825284
122CSNK1E0.31495895
123FER0.31037676
124MAPK90.30395522
125CCNB10.29832314
126GSK3B0.28951438

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.63050370
2Synaptic vesicle cycle_Homo sapiens_hsa047213.54198409
3Olfactory transduction_Homo sapiens_hsa047402.61106026
4GABAergic synapse_Homo sapiens_hsa047272.60943806
5Circadian entrainment_Homo sapiens_hsa047132.58047371
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.52266326
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46848664
8Glutamatergic synapse_Homo sapiens_hsa047242.46329744
9Long-term potentiation_Homo sapiens_hsa047202.36354643
10Morphine addiction_Homo sapiens_hsa050322.30055447
11Insulin secretion_Homo sapiens_hsa049112.09576388
12Dopaminergic synapse_Homo sapiens_hsa047282.08712709
13Amphetamine addiction_Homo sapiens_hsa050312.05117961
14Salivary secretion_Homo sapiens_hsa049702.03175400
15Cholinergic synapse_Homo sapiens_hsa047251.89534805
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87727653
17Taste transduction_Homo sapiens_hsa047421.83294558
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80218723
19Gastric acid secretion_Homo sapiens_hsa049711.73395748
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69346156
21Long-term depression_Homo sapiens_hsa047301.59237432
22Serotonergic synapse_Homo sapiens_hsa047261.52073326
23Oxytocin signaling pathway_Homo sapiens_hsa049211.49397150
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48065829
25Type II diabetes mellitus_Homo sapiens_hsa049301.47999936
26GnRH signaling pathway_Homo sapiens_hsa049121.44853387
27Cocaine addiction_Homo sapiens_hsa050301.42371346
28Gap junction_Homo sapiens_hsa045401.38961327
29Axon guidance_Homo sapiens_hsa043601.37502833
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36546105
31Renin secretion_Homo sapiens_hsa049241.36518698
32Calcium signaling pathway_Homo sapiens_hsa040201.34490632
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28642170
34Estrogen signaling pathway_Homo sapiens_hsa049151.23159336
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23061756
36cAMP signaling pathway_Homo sapiens_hsa040241.19605972
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18664633
38Phototransduction_Homo sapiens_hsa047441.18156392
39ErbB signaling pathway_Homo sapiens_hsa040121.17494625
40Glioma_Homo sapiens_hsa052141.16659755
41Vitamin B6 metabolism_Homo sapiens_hsa007501.12236522
42Melanogenesis_Homo sapiens_hsa049161.01829041
43Butanoate metabolism_Homo sapiens_hsa006500.99144845
44Collecting duct acid secretion_Homo sapiens_hsa049660.97750856
45Oocyte meiosis_Homo sapiens_hsa041140.96256939
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.95327365
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93119896
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.90249706
49Dorso-ventral axis formation_Homo sapiens_hsa043200.90181373
50Endometrial cancer_Homo sapiens_hsa052130.89727669
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89364805
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87633704
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87532586
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82017076
55Oxidative phosphorylation_Homo sapiens_hsa001900.81982749
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80735991
57Choline metabolism in cancer_Homo sapiens_hsa052310.80446483
58MAPK signaling pathway_Homo sapiens_hsa040100.77899998
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77898262
60Thyroid hormone synthesis_Homo sapiens_hsa049180.76322674
61Pancreatic secretion_Homo sapiens_hsa049720.76111615
62Alzheimers disease_Homo sapiens_hsa050100.75528356
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73966569
64mTOR signaling pathway_Homo sapiens_hsa041500.72705938
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72213823
66Ether lipid metabolism_Homo sapiens_hsa005650.71477682
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.70700708
68Parkinsons disease_Homo sapiens_hsa050120.69318702
69Vibrio cholerae infection_Homo sapiens_hsa051100.66987810
70VEGF signaling pathway_Homo sapiens_hsa043700.65384568
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64237596
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63554778
73Cardiac muscle contraction_Homo sapiens_hsa042600.63155841
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61715751
75Dilated cardiomyopathy_Homo sapiens_hsa054140.61435468
76Endocytosis_Homo sapiens_hsa041440.61237284
77Insulin signaling pathway_Homo sapiens_hsa049100.61160925
78Colorectal cancer_Homo sapiens_hsa052100.60381816
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60053809
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.59271275
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58697041
82Ras signaling pathway_Homo sapiens_hsa040140.58379069
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58142766
84Inositol phosphate metabolism_Homo sapiens_hsa005620.57850786
85Nitrogen metabolism_Homo sapiens_hsa009100.56722355
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56584283
87Linoleic acid metabolism_Homo sapiens_hsa005910.55754858
88Circadian rhythm_Homo sapiens_hsa047100.55399023
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54538014
90Glucagon signaling pathway_Homo sapiens_hsa049220.52752769
91Wnt signaling pathway_Homo sapiens_hsa043100.51079587
92Prolactin signaling pathway_Homo sapiens_hsa049170.50550635
93Alcoholism_Homo sapiens_hsa050340.50507125
94Rap1 signaling pathway_Homo sapiens_hsa040150.50244228
95Bile secretion_Homo sapiens_hsa049760.50022448
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49754848
97Regulation of autophagy_Homo sapiens_hsa041400.48896609
98Non-small cell lung cancer_Homo sapiens_hsa052230.47996776
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47981810
100Renal cell carcinoma_Homo sapiens_hsa052110.46768895
101Fatty acid biosynthesis_Homo sapiens_hsa000610.44445773
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43113445
103ABC transporters_Homo sapiens_hsa020100.42857493
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41909959
105Chemokine signaling pathway_Homo sapiens_hsa040620.40422531
106Type I diabetes mellitus_Homo sapiens_hsa049400.40389081
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39717754
108Hippo signaling pathway_Homo sapiens_hsa043900.38880323
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38872405
110Prion diseases_Homo sapiens_hsa050200.37020091
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35293026
112Huntingtons disease_Homo sapiens_hsa050160.34542542
113Arginine and proline metabolism_Homo sapiens_hsa003300.33687738
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32991475
115Ovarian steroidogenesis_Homo sapiens_hsa049130.32359848
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31943935
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31587009
118beta-Alanine metabolism_Homo sapiens_hsa004100.31413504
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.31144008
120Hedgehog signaling pathway_Homo sapiens_hsa043400.30940336
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30889746
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.30826965
123Mineral absorption_Homo sapiens_hsa049780.22263576

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