

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 6.63923666 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.42796737 |
| 3 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.98495302 |
| 4 | locomotory exploration behavior (GO:0035641) | 5.82191919 |
| 5 | vocalization behavior (GO:0071625) | 5.45725593 |
| 6 | glutamate secretion (GO:0014047) | 5.44469709 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.40385741 |
| 8 | synaptic vesicle exocytosis (GO:0016079) | 5.38757993 |
| 9 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.35617379 |
| 10 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.16093002 |
| 11 | layer formation in cerebral cortex (GO:0021819) | 4.97848448 |
| 12 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.95912719 |
| 13 | protein localization to synapse (GO:0035418) | 4.86363053 |
| 14 | regulation of synaptic vesicle transport (GO:1902803) | 4.77783556 |
| 15 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.73338123 |
| 16 | response to pheromone (GO:0019236) | 4.68491289 |
| 17 | neurotransmitter secretion (GO:0007269) | 4.66594390 |
| 18 | exploration behavior (GO:0035640) | 4.64357025 |
| 19 | neuron cell-cell adhesion (GO:0007158) | 4.61720210 |
| 20 | proline transport (GO:0015824) | 4.49630491 |
| 21 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.48985296 |
| 22 | gamma-aminobutyric acid transport (GO:0015812) | 4.36323737 |
| 23 | cellular potassium ion homeostasis (GO:0030007) | 4.29247214 |
| 24 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.24269625 |
| 25 | neuronal action potential propagation (GO:0019227) | 4.17692747 |
| 26 | cerebellar Purkinje cell differentiation (GO:0021702) | 4.17579987 |
| 27 | cell migration in hindbrain (GO:0021535) | 4.12803680 |
| 28 | synaptic transmission, glutamatergic (GO:0035249) | 4.11779713 |
| 29 | sodium ion export (GO:0071436) | 4.07913440 |
| 30 | regulation of synapse structural plasticity (GO:0051823) | 4.06925134 |
| 31 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.05739897 |
| 32 | dendritic spine morphogenesis (GO:0060997) | 4.04015148 |
| 33 | dendrite morphogenesis (GO:0048813) | 3.90640463 |
| 34 | glutamate receptor signaling pathway (GO:0007215) | 3.89444423 |
| 35 | positive regulation of synapse maturation (GO:0090129) | 3.89075504 |
| 36 | behavioral response to nicotine (GO:0035095) | 3.86160064 |
| 37 | presynaptic membrane assembly (GO:0097105) | 3.84577752 |
| 38 | presynaptic membrane organization (GO:0097090) | 3.78797676 |
| 39 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.78588237 |
| 40 | glycine transport (GO:0015816) | 3.76996812 |
| 41 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.76688457 |
| 42 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.75544361 |
| 43 | synaptic vesicle endocytosis (GO:0048488) | 3.75042194 |
| 44 | neurotransmitter transport (GO:0006836) | 3.74248544 |
| 45 | establishment of mitochondrion localization (GO:0051654) | 3.74054993 |
| 46 | neuron recognition (GO:0008038) | 3.72411584 |
| 47 | cell communication by electrical coupling (GO:0010644) | 3.70038304 |
| 48 | postsynaptic membrane organization (GO:0001941) | 3.67542532 |
| 49 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.66586951 |
| 50 | neuron-neuron synaptic transmission (GO:0007270) | 3.66200030 |
| 51 | neuromuscular process controlling posture (GO:0050884) | 3.63819738 |
| 52 | axon ensheathment in central nervous system (GO:0032291) | 3.62678217 |
| 53 | central nervous system myelination (GO:0022010) | 3.62678217 |
| 54 | positive regulation of membrane potential (GO:0045838) | 3.60359655 |
| 55 | long-term memory (GO:0007616) | 3.59717727 |
| 56 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.59218647 |
| 57 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.58994398 |
| 58 | activation of protein kinase A activity (GO:0034199) | 3.58679404 |
| 59 | neuromuscular process controlling balance (GO:0050885) | 3.58325829 |
| 60 | nucleobase catabolic process (GO:0046113) | 3.56971501 |
| 61 | axonal fasciculation (GO:0007413) | 3.56229748 |
| 62 | regulation of neurotransmitter secretion (GO:0046928) | 3.54232311 |
| 63 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.45766982 |
| 64 | mechanosensory behavior (GO:0007638) | 3.44950741 |
| 65 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.44661177 |
| 66 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.44498646 |
| 67 | membrane depolarization during action potential (GO:0086010) | 3.42686620 |
| 68 | regulation of neurotransmitter levels (GO:0001505) | 3.40617491 |
| 69 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.39511290 |
| 70 | axon cargo transport (GO:0008088) | 3.38952845 |
| 71 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.36002427 |
| 72 | negative regulation of microtubule polymerization (GO:0031115) | 3.34438243 |
| 73 | response to auditory stimulus (GO:0010996) | 3.33092669 |
| 74 | auditory behavior (GO:0031223) | 3.32150558 |
| 75 | transmission of nerve impulse (GO:0019226) | 3.31840573 |
| 76 | regulation of postsynaptic membrane potential (GO:0060078) | 3.31344843 |
| 77 | cerebellar granule cell differentiation (GO:0021707) | 3.27616918 |
| 78 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.26623565 |
| 79 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.24518801 |
| 80 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.23662435 |
| 81 | potassium ion import (GO:0010107) | 3.22364031 |
| 82 | innervation (GO:0060384) | 3.22214387 |
| 83 | regulation of synaptic plasticity (GO:0048167) | 3.19417351 |
| 84 | adult walking behavior (GO:0007628) | 3.18961748 |
| 85 | regulation of vesicle fusion (GO:0031338) | 3.16650067 |
| 86 | regulation of neurotransmitter transport (GO:0051588) | 3.16452301 |
| 87 | L-amino acid import (GO:0043092) | 3.16084190 |
| 88 | synapse assembly (GO:0007416) | 3.15340923 |
| 89 | organelle transport along microtubule (GO:0072384) | 3.14961203 |
| 90 | regulation of synapse maturation (GO:0090128) | 3.12743843 |
| 91 | membrane hyperpolarization (GO:0060081) | 3.11809789 |
| 92 | vesicle transport along microtubule (GO:0047496) | 3.11173042 |
| 93 | positive regulation of neurotransmitter transport (GO:0051590) | 3.10872651 |
| 94 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.09464038 |
| 95 | synaptic transmission (GO:0007268) | 3.09461865 |
| 96 | regulation of ARF protein signal transduction (GO:0032012) | 3.09404374 |
| 97 | dendritic spine organization (GO:0097061) | 3.09120589 |
| 98 | mitochondrion transport along microtubule (GO:0047497) | 3.08239272 |
| 99 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.08239272 |
| 100 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.08020858 |
| 101 | neuromuscular process (GO:0050905) | 3.07262900 |
| 102 | membrane depolarization (GO:0051899) | 3.07065610 |
| 103 | cerebellar Purkinje cell layer development (GO:0021680) | 3.06364381 |
| 104 | cell differentiation in hindbrain (GO:0021533) | 3.04872289 |
| 105 | startle response (GO:0001964) | 3.03713311 |
| 106 | social behavior (GO:0035176) | 3.02671732 |
| 107 | intraspecies interaction between organisms (GO:0051703) | 3.02671732 |
| 108 | neuronal ion channel clustering (GO:0045161) | 3.00064359 |
| 109 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.98657825 |
| 110 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.98509952 |
| 111 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.97954777 |
| 112 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.97898035 |
| 113 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.96828609 |
| 114 | positive regulation of synapse assembly (GO:0051965) | 2.96021013 |
| 115 | regulation of dendritic spine development (GO:0060998) | 2.95902563 |
| 116 | potassium ion homeostasis (GO:0055075) | 2.93436183 |
| 117 | establishment of nucleus localization (GO:0040023) | 2.93045248 |
| 118 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.92059222 |
| 119 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.91402678 |
| 120 | positive regulation of dendritic spine development (GO:0060999) | 2.91260448 |
| 121 | neuromuscular synaptic transmission (GO:0007274) | 2.90772061 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.22759706 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.24924374 |
| 3 | REST_21632747_ChIP-Seq_MESCs_Mouse | 3.01121454 |
| 4 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.99357465 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.96096758 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.90142391 |
| 7 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.74949705 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.72118129 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.72118129 |
| 10 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.61730413 |
| 11 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.59746937 |
| 12 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.53016986 |
| 13 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.45683413 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.45581263 |
| 15 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.45131440 |
| 16 | * EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.44787929 |
| 17 | * SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.42581298 |
| 18 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.41252357 |
| 19 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.40085548 |
| 20 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.36524141 |
| 21 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.28922561 |
| 22 | * SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.25251414 |
| 23 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.23092449 |
| 24 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.23091397 |
| 25 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.20775166 |
| 26 | * NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.15424979 |
| 27 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.12101593 |
| 28 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.05595252 |
| 29 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.98957545 |
| 30 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.66239997 |
| 31 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.64802299 |
| 32 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.62075325 |
| 33 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.52300652 |
| 34 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.51164079 |
| 35 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.50378609 |
| 36 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.47667755 |
| 37 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.47017946 |
| 38 | KDM2B_26808549_Chip-Seq_K562_Human | 1.40397257 |
| 39 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.37287364 |
| 40 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.37169275 |
| 41 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.36838746 |
| 42 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.33430228 |
| 43 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.32789874 |
| 44 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.27590111 |
| 45 | AR_19668381_ChIP-Seq_PC3_Human | 1.27581082 |
| 46 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.26603813 |
| 47 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.24323397 |
| 48 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.23200949 |
| 49 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.23128752 |
| 50 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.22955439 |
| 51 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.21411608 |
| 52 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.21404508 |
| 53 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.19625442 |
| 54 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.18381238 |
| 55 | STAT3_23295773_ChIP-Seq_U87_Human | 1.18367586 |
| 56 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.17644319 |
| 57 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.17190069 |
| 58 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15617178 |
| 59 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.14042509 |
| 60 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.13017598 |
| 61 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.12898761 |
| 62 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.11475214 |
| 63 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.10816718 |
| 64 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.10754916 |
| 65 | * AR_25329375_ChIP-Seq_VCAP_Human | 1.10319760 |
| 66 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.10055335 |
| 67 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.09942309 |
| 68 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.09134012 |
| 69 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.08677671 |
| 70 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.08237971 |
| 71 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.07086932 |
| 72 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.06886720 |
| 73 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.05852018 |
| 74 | P300_19829295_ChIP-Seq_ESCs_Human | 1.05065672 |
| 75 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.03071250 |
| 76 | VDR_22108803_ChIP-Seq_LS180_Human | 1.01987430 |
| 77 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.01442598 |
| 78 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.01302197 |
| 79 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.01288795 |
| 80 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.01264704 |
| 81 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.00997100 |
| 82 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.98802016 |
| 83 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.98384339 |
| 84 | * TCF4_23295773_ChIP-Seq_U87_Human | 0.97403052 |
| 85 | * OCT4_19829295_ChIP-Seq_ESCs_Human | 0.97322343 |
| 86 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.96108131 |
| 87 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.95832981 |
| 88 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.95297498 |
| 89 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.94313568 |
| 90 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.93621214 |
| 91 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.93259957 |
| 92 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.92831321 |
| 93 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.92367710 |
| 94 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.92313859 |
| 95 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.91505155 |
| 96 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.90536489 |
| 97 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.88255637 |
| 98 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.87319535 |
| 99 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.87319535 |
| 100 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.86835779 |
| 101 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.86043778 |
| 102 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.85690610 |
| 103 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.84840956 |
| 104 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.84683832 |
| 105 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.84456218 |
| 106 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.84145096 |
| 107 | * FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.84010400 |
| 108 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.83804555 |
| 109 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.83624807 |
| 110 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.82472571 |
| 111 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.82397518 |
| 112 | * MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.80754667 |
| 113 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.79873307 |
| 114 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.78017923 |
| 115 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.77134872 |
| 116 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.76969866 |
| 117 | ERA_21632823_ChIP-Seq_H3396_Human | 0.74234835 |
| 118 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.73439191 |
| 119 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.73048681 |
| 120 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.73006808 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.30589005 |
| 2 | MP0003880_abnormal_central_pattern | 4.14411651 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.01686393 |
| 4 | MP0004270_analgesia | 3.95894795 |
| 5 | MP0005423_abnormal_somatic_nervous | 3.64125913 |
| 6 | MP0001968_abnormal_touch/_nociception | 3.29364172 |
| 7 | MP0009046_muscle_twitch | 3.21211451 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.13783367 |
| 9 | MP0002735_abnormal_chemical_nociception | 3.05540161 |
| 10 | MP0009745_abnormal_behavioral_response | 3.03780393 |
| 11 | MP0002734_abnormal_mechanical_nocicepti | 3.03716360 |
| 12 | MP0002064_seizures | 2.89300567 |
| 13 | MP0002572_abnormal_emotion/affect_behav | 2.57206395 |
| 14 | MP0002733_abnormal_thermal_nociception | 2.48168005 |
| 15 | MP0002736_abnormal_nociception_after | 2.47237237 |
| 16 | MP0002272_abnormal_nervous_system | 2.46040680 |
| 17 | MP0004858_abnormal_nervous_system | 2.45686691 |
| 18 | MP0001486_abnormal_startle_reflex | 2.39287738 |
| 19 | MP0006276_abnormal_autonomic_nervous | 2.32379472 |
| 20 | MP0002184_abnormal_innervation | 2.25401523 |
| 21 | MP0000778_abnormal_nervous_system | 2.21979655 |
| 22 | MP0001970_abnormal_pain_threshold | 2.21841079 |
| 23 | MP0002067_abnormal_sensory_capabilities | 2.07787881 |
| 24 | MP0004811_abnormal_neuron_physiology | 2.04127397 |
| 25 | MP0001440_abnormal_grooming_behavior | 2.01422719 |
| 26 | MP0008569_lethality_at_weaning | 2.00628698 |
| 27 | MP0001501_abnormal_sleep_pattern | 1.97620821 |
| 28 | MP0005645_abnormal_hypothalamus_physiol | 1.86401921 |
| 29 | MP0002557_abnormal_social/conspecific_i | 1.85493963 |
| 30 | MP0000569_abnormal_digit_pigmentation | 1.83717025 |
| 31 | MP0000955_abnormal_spinal_cord | 1.83028401 |
| 32 | MP0003329_amyloid_beta_deposits | 1.81127711 |
| 33 | MP0009780_abnormal_chondrocyte_physiolo | 1.76107841 |
| 34 | MP0003787_abnormal_imprinting | 1.74199320 |
| 35 | MP0002909_abnormal_adrenal_gland | 1.70498296 |
| 36 | MP0004924_abnormal_behavior | 1.66357741 |
| 37 | MP0005386_behavior/neurological_phenoty | 1.66357741 |
| 38 | MP0004885_abnormal_endolymph | 1.64043308 |
| 39 | MP0001984_abnormal_olfaction | 1.62085764 |
| 40 | MP0002882_abnormal_neuron_morphology | 1.60420330 |
| 41 | MP0003879_abnormal_hair_cell | 1.48483460 |
| 42 | MP0005646_abnormal_pituitary_gland | 1.45754995 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.45099926 |
| 44 | MP0001502_abnormal_circadian_rhythm | 1.42905801 |
| 45 | MP0008877_abnormal_DNA_methylation | 1.39468483 |
| 46 | MP0003122_maternal_imprinting | 1.38325396 |
| 47 | MP0003633_abnormal_nervous_system | 1.26921371 |
| 48 | MP0004142_abnormal_muscle_tone | 1.26011749 |
| 49 | MP0002152_abnormal_brain_morphology | 1.22235213 |
| 50 | MP0003283_abnormal_digestive_organ | 1.18041199 |
| 51 | MP0002229_neurodegeneration | 1.12893894 |
| 52 | MP0010386_abnormal_urinary_bladder | 1.11856556 |
| 53 | MP0003631_nervous_system_phenotype | 1.09900516 |
| 54 | MP0002822_catalepsy | 1.06957267 |
| 55 | MP0001485_abnormal_pinna_reflex | 1.06690836 |
| 56 | MP0005551_abnormal_eye_electrophysiolog | 1.06669652 |
| 57 | MP0005499_abnormal_olfactory_system | 1.04984006 |
| 58 | MP0005394_taste/olfaction_phenotype | 1.04984006 |
| 59 | MP0004147_increased_porphyrin_level | 1.04499825 |
| 60 | MP0002638_abnormal_pupillary_reflex | 1.02769338 |
| 61 | MP0004145_abnormal_muscle_electrophysio | 1.00824610 |
| 62 | MP0003123_paternal_imprinting | 1.00582637 |
| 63 | MP0004133_heterotaxia | 0.98923534 |
| 64 | MP0001348_abnormal_lacrimal_gland | 0.98284720 |
| 65 | MP0008961_abnormal_basal_metabolism | 0.98019364 |
| 66 | MP0002102_abnormal_ear_morphology | 0.97663625 |
| 67 | MP0002752_abnormal_somatic_nervous | 0.95178993 |
| 68 | MP0004742_abnormal_vestibular_system | 0.94748443 |
| 69 | MP0002069_abnormal_eating/drinking_beha | 0.91712160 |
| 70 | MP0003634_abnormal_glial_cell | 0.88977402 |
| 71 | MP0003632_abnormal_nervous_system | 0.86017336 |
| 72 | MP0006292_abnormal_olfactory_placode | 0.83469253 |
| 73 | MP0002876_abnormal_thyroid_physiology | 0.83165667 |
| 74 | MP0001188_hyperpigmentation | 0.82786797 |
| 75 | MP0000026_abnormal_inner_ear | 0.81595566 |
| 76 | MP0001905_abnormal_dopamine_level | 0.81539650 |
| 77 | MP0003136_yellow_coat_color | 0.80875823 |
| 78 | MP0008872_abnormal_physiological_respon | 0.80802382 |
| 79 | MP0003172_abnormal_lysosome_physiology | 0.80606308 |
| 80 | MP0000631_abnormal_neuroendocrine_gland | 0.80504925 |
| 81 | MP0001963_abnormal_hearing_physiology | 0.78871725 |
| 82 | MP0003861_abnormal_nervous_system | 0.77538465 |
| 83 | MP0001177_atelectasis | 0.77142862 |
| 84 | MP0000604_amyloidosis | 0.72893463 |
| 85 | MP0001299_abnormal_eye_distance/ | 0.72670979 |
| 86 | MP0000751_myopathy | 0.72374122 |
| 87 | MP0003938_abnormal_ear_development | 0.71863303 |
| 88 | MP0003119_abnormal_digestive_system | 0.71035784 |
| 89 | MP0005167_abnormal_blood-brain_barrier | 0.70835366 |
| 90 | MP0001986_abnormal_taste_sensitivity | 0.69815893 |
| 91 | MP0004085_abnormal_heartbeat | 0.69475043 |
| 92 | MP0004043_abnormal_pH_regulation | 0.68251926 |
| 93 | MP0008874_decreased_physiological_sensi | 0.66899081 |
| 94 | MP0001529_abnormal_vocalization | 0.65818403 |
| 95 | MP0003137_abnormal_impulse_conducting | 0.65791369 |
| 96 | MP0006072_abnormal_retinal_apoptosis | 0.65781465 |
| 97 | MP0003690_abnormal_glial_cell | 0.65737094 |
| 98 | MP0005187_abnormal_penis_morphology | 0.64971749 |
| 99 | MP0002653_abnormal_ependyma_morphology | 0.64805171 |
| 100 | MP0004233_abnormal_muscle_weight | 0.63872951 |
| 101 | MP0005535_abnormal_body_temperature | 0.63864759 |
| 102 | MP0004130_abnormal_muscle_cell | 0.63386519 |
| 103 | MP0002751_abnormal_autonomic_nervous | 0.62762390 |
| 104 | MP0010769_abnormal_survival | 0.62461334 |
| 105 | MP0000920_abnormal_myelination | 0.61043182 |
| 106 | MP0002082_postnatal_lethality | 0.60460280 |
| 107 | MP0010770_preweaning_lethality | 0.60460280 |
| 108 | MP0001346_abnormal_lacrimal_gland | 0.60388273 |
| 109 | MP0005253_abnormal_eye_physiology | 0.60380283 |
| 110 | MP0002249_abnormal_larynx_morphology | 0.59883690 |
| 111 | MP0010768_mortality/aging | 0.58872824 |
| 112 | MP0001943_abnormal_respiration | 0.55295423 |
| 113 | MP0003121_genomic_imprinting | 0.54447871 |
| 114 | MP0000013_abnormal_adipose_tissue | 0.52800552 |
| 115 | MP0003956_abnormal_body_size | 0.51465664 |
| 116 | MP0002089_abnormal_postnatal_growth/wei | 0.50178753 |
| 117 | MP0003075_altered_response_to | 0.49645028 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 6.11645933 |
| 2 | Focal motor seizures (HP:0011153) | 5.78451992 |
| 3 | Focal seizures (HP:0007359) | 5.15988100 |
| 4 | Visual hallucinations (HP:0002367) | 5.11013431 |
| 5 | Progressive cerebellar ataxia (HP:0002073) | 4.71896792 |
| 6 | Action tremor (HP:0002345) | 4.64730081 |
| 7 | Supranuclear gaze palsy (HP:0000605) | 4.37713763 |
| 8 | Epileptic encephalopathy (HP:0200134) | 4.36567404 |
| 9 | Febrile seizures (HP:0002373) | 4.22423483 |
| 10 | Mutism (HP:0002300) | 4.01136199 |
| 11 | Ankle clonus (HP:0011448) | 3.88471211 |
| 12 | Atonic seizures (HP:0010819) | 3.77423248 |
| 13 | Absence seizures (HP:0002121) | 3.48776809 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 3.37880542 |
| 15 | Genetic anticipation (HP:0003743) | 3.33530058 |
| 16 | Poor eye contact (HP:0000817) | 3.29575886 |
| 17 | Papilledema (HP:0001085) | 3.26001596 |
| 18 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.24731486 |
| 19 | Depression (HP:0000716) | 3.22953993 |
| 20 | Abnormality of the lower motor neuron (HP:0002366) | 3.17872513 |
| 21 | Broad-based gait (HP:0002136) | 3.13848262 |
| 22 | Dialeptic seizures (HP:0011146) | 3.10473200 |
| 23 | Gaze-evoked nystagmus (HP:0000640) | 3.09812842 |
| 24 | Truncal ataxia (HP:0002078) | 3.00754878 |
| 25 | Impaired social interactions (HP:0000735) | 2.98364203 |
| 26 | Abnormal social behavior (HP:0012433) | 2.98364203 |
| 27 | Abnormal eating behavior (HP:0100738) | 2.95950515 |
| 28 | Postural instability (HP:0002172) | 2.95908238 |
| 29 | Abnormality of the corticospinal tract (HP:0002492) | 2.95145346 |
| 30 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.88778469 |
| 31 | Excessive salivation (HP:0003781) | 2.82863040 |
| 32 | Drooling (HP:0002307) | 2.82863040 |
| 33 | Dysdiadochokinesis (HP:0002075) | 2.81346139 |
| 34 | Urinary urgency (HP:0000012) | 2.78380853 |
| 35 | Hemiparesis (HP:0001269) | 2.78218892 |
| 36 | Insomnia (HP:0100785) | 2.76628375 |
| 37 | Spastic gait (HP:0002064) | 2.72487869 |
| 38 | Amyotrophic lateral sclerosis (HP:0007354) | 2.71718850 |
| 39 | Impaired smooth pursuit (HP:0007772) | 2.71561308 |
| 40 | Limb dystonia (HP:0002451) | 2.70055974 |
| 41 | Dysmetria (HP:0001310) | 2.63961639 |
| 42 | Torticollis (HP:0000473) | 2.61496945 |
| 43 | Agitation (HP:0000713) | 2.60349109 |
| 44 | Ventricular fibrillation (HP:0001663) | 2.58072673 |
| 45 | Hemiplegia (HP:0002301) | 2.56193981 |
| 46 | Cerebral hypomyelination (HP:0006808) | 2.55807722 |
| 47 | Anxiety (HP:0000739) | 2.55498991 |
| 48 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.53897587 |
| 49 | Insidious onset (HP:0003587) | 2.49722381 |
| 50 | Termporal pattern (HP:0011008) | 2.49722381 |
| 51 | Diplopia (HP:0000651) | 2.49370892 |
| 52 | Abnormality of binocular vision (HP:0011514) | 2.49370892 |
| 53 | Amblyopia (HP:0000646) | 2.46041440 |
| 54 | Progressive inability to walk (HP:0002505) | 2.45608457 |
| 55 | Polyphagia (HP:0002591) | 2.44239995 |
| 56 | Pheochromocytoma (HP:0002666) | 2.42499974 |
| 57 | Scanning speech (HP:0002168) | 2.36787083 |
| 58 | EEG with generalized epileptiform discharges (HP:0011198) | 2.36586284 |
| 59 | Bradykinesia (HP:0002067) | 2.36301824 |
| 60 | Intention tremor (HP:0002080) | 2.35877056 |
| 61 | Epileptiform EEG discharges (HP:0011182) | 2.34775835 |
| 62 | Lower limb muscle weakness (HP:0007340) | 2.34347280 |
| 63 | Gait imbalance (HP:0002141) | 2.33858659 |
| 64 | Fetal akinesia sequence (HP:0001989) | 2.33297395 |
| 65 | Annular pancreas (HP:0001734) | 2.33212758 |
| 66 | Focal dystonia (HP:0004373) | 2.30546594 |
| 67 | Hypsarrhythmia (HP:0002521) | 2.28381086 |
| 68 | Type II lissencephaly (HP:0007260) | 2.25799136 |
| 69 | Stereotypic behavior (HP:0000733) | 2.24061340 |
| 70 | Inappropriate behavior (HP:0000719) | 2.22977582 |
| 71 | Obstructive sleep apnea (HP:0002870) | 2.22739270 |
| 72 | Pointed chin (HP:0000307) | 2.21471134 |
| 73 | Retinal dysplasia (HP:0007973) | 2.19680266 |
| 74 | Lissencephaly (HP:0001339) | 2.15295556 |
| 75 | Akinesia (HP:0002304) | 2.14682819 |
| 76 | Failure to thrive in infancy (HP:0001531) | 2.14439498 |
| 77 | Absent speech (HP:0001344) | 2.12472779 |
| 78 | Spastic tetraparesis (HP:0001285) | 2.12001607 |
| 79 | Aqueductal stenosis (HP:0002410) | 2.10868454 |
| 80 | Dysmetric saccades (HP:0000641) | 2.10679207 |
| 81 | Hyperacusis (HP:0010780) | 2.10538004 |
| 82 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.10019038 |
| 83 | Megalencephaly (HP:0001355) | 2.09728994 |
| 84 | Clonus (HP:0002169) | 2.09565754 |
| 85 | Hypoplasia of the brainstem (HP:0002365) | 2.08267753 |
| 86 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.08267753 |
| 87 | Hyperventilation (HP:0002883) | 2.08251848 |
| 88 | Congenital stationary night blindness (HP:0007642) | 2.07752482 |
| 89 | Apathy (HP:0000741) | 2.07234635 |
| 90 | Craniofacial dystonia (HP:0012179) | 2.06341412 |
| 91 | Spastic tetraplegia (HP:0002510) | 2.06266751 |
| 92 | CNS hypomyelination (HP:0003429) | 2.04674372 |
| 93 | Elfin facies (HP:0004428) | 2.02178749 |
| 94 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.02108868 |
| 95 | Inability to walk (HP:0002540) | 1.99354825 |
| 96 | Neurofibrillary tangles (HP:0002185) | 1.99271723 |
| 97 | Status epilepticus (HP:0002133) | 1.97990793 |
| 98 | Neuroendocrine neoplasm (HP:0100634) | 1.97312372 |
| 99 | Impaired vibratory sensation (HP:0002495) | 1.96597973 |
| 100 | Ulnar claw (HP:0001178) | 1.96218793 |
| 101 | Nephronophthisis (HP:0000090) | 1.95980380 |
| 102 | Abnormality of the labia minora (HP:0012880) | 1.95344291 |
| 103 | Sleep apnea (HP:0010535) | 1.94527936 |
| 104 | Delusions (HP:0000746) | 1.89722072 |
| 105 | Molar tooth sign on MRI (HP:0002419) | 1.89206707 |
| 106 | Abnormality of midbrain morphology (HP:0002418) | 1.89206707 |
| 107 | Bundle branch block (HP:0011710) | 1.85263457 |
| 108 | Abnormality of salivation (HP:0100755) | 1.85051420 |
| 109 | Pachygyria (HP:0001302) | 1.83650401 |
| 110 | Tetraplegia (HP:0002445) | 1.83568208 |
| 111 | Cerebral inclusion bodies (HP:0100314) | 1.83510895 |
| 112 | Specific learning disability (HP:0001328) | 1.83293099 |
| 113 | Paraplegia (HP:0010550) | 1.83241473 |
| 114 | Hypoplasia of the corpus callosum (HP:0002079) | 1.81961715 |
| 115 | Spastic paraplegia (HP:0001258) | 1.81814039 |
| 116 | Gait ataxia (HP:0002066) | 1.81411322 |
| 117 | Protruding tongue (HP:0010808) | 1.81372714 |
| 118 | Diminished motivation (HP:0000745) | 1.80891562 |
| 119 | True hermaphroditism (HP:0010459) | 1.78937454 |
| 120 | Decreased central vision (HP:0007663) | 1.77116983 |
| 121 | Pancreatic cysts (HP:0001737) | 1.76330297 |
| 122 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.75177859 |
| 123 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.75177859 |
| 124 | Incomplete penetrance (HP:0003829) | 1.73550949 |
| 125 | Pancreatic fibrosis (HP:0100732) | 1.72997943 |
| 126 | Oligodactyly (hands) (HP:0001180) | 1.72157415 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 5.21151623 |
| 2 | MAP3K9 | 4.29731571 |
| 3 | NTRK3 | 4.11372594 |
| 4 | MINK1 | 3.23120003 |
| 5 | MAP3K4 | 3.21166737 |
| 6 | MAP2K7 | 2.76314055 |
| 7 | PAK6 | 2.64335410 |
| 8 | NTRK2 | 2.37958551 |
| 9 | DAPK2 | 2.26042152 |
| 10 | EPHA4 | 2.07389141 |
| 11 | MAP2K4 | 1.97650392 |
| 12 | CAMKK1 | 1.95480074 |
| 13 | NTRK1 | 1.91284571 |
| 14 | LATS2 | 1.89464776 |
| 15 | PRKD3 | 1.85346318 |
| 16 | MAPK13 | 1.77959441 |
| 17 | PHKG1 | 1.74947695 |
| 18 | PHKG2 | 1.74947695 |
| 19 | STK38 | 1.63398662 |
| 20 | KSR2 | 1.59323006 |
| 21 | MAP3K12 | 1.57663455 |
| 22 | CDK5 | 1.53112842 |
| 23 | SIK2 | 1.49664622 |
| 24 | KSR1 | 1.47439090 |
| 25 | WNK4 | 1.38870652 |
| 26 | INSRR | 1.35971024 |
| 27 | TNIK | 1.32820364 |
| 28 | MAP4K2 | 1.28705859 |
| 29 | LMTK2 | 1.25159875 |
| 30 | UHMK1 | 1.23871445 |
| 31 | FRK | 1.23300935 |
| 32 | CASK | 1.21812336 |
| 33 | PRKCG | 1.21661301 |
| 34 | GRK5 | 1.18004585 |
| 35 | PNCK | 1.15122109 |
| 36 | ADRBK2 | 1.14786956 |
| 37 | PRPF4B | 1.13321015 |
| 38 | TAOK1 | 1.12495059 |
| 39 | PLK2 | 1.12044672 |
| 40 | CAMKK2 | 1.10480451 |
| 41 | DAPK1 | 1.09437001 |
| 42 | ALK | 1.08736931 |
| 43 | CDK19 | 1.06269575 |
| 44 | SGK494 | 1.01098687 |
| 45 | SGK223 | 1.01098687 |
| 46 | RET | 0.98551953 |
| 47 | MAP3K2 | 0.94673565 |
| 48 | PRKCH | 0.94565898 |
| 49 | OXSR1 | 0.93660361 |
| 50 | ERBB3 | 0.93384573 |
| 51 | TYRO3 | 0.92503034 |
| 52 | STK11 | 0.92128567 |
| 53 | BMPR1B | 0.91721437 |
| 54 | CDK18 | 0.90478532 |
| 55 | SGK2 | 0.87567696 |
| 56 | CDK15 | 0.87311379 |
| 57 | CSNK1G2 | 0.87027276 |
| 58 | CAMK1 | 0.86178468 |
| 59 | RIPK4 | 0.85026666 |
| 60 | PINK1 | 0.84275141 |
| 61 | SGK3 | 0.84065542 |
| 62 | CDK14 | 0.83769325 |
| 63 | DYRK2 | 0.83033360 |
| 64 | BCR | 0.81716359 |
| 65 | DYRK1A | 0.80389013 |
| 66 | RIPK1 | 0.79560836 |
| 67 | TLK1 | 0.79012432 |
| 68 | CAMK1G | 0.78456225 |
| 69 | MARK2 | 0.77792225 |
| 70 | PAK3 | 0.77341552 |
| 71 | FGFR2 | 0.76886842 |
| 72 | CDK11A | 0.75829256 |
| 73 | CAMK2A | 0.69888043 |
| 74 | RPS6KA2 | 0.68364251 |
| 75 | SCYL2 | 0.68348324 |
| 76 | FES | 0.68154517 |
| 77 | CDC42BPA | 0.65775575 |
| 78 | PRKCZ | 0.65338986 |
| 79 | ICK | 0.62477621 |
| 80 | WNK1 | 0.62303490 |
| 81 | LIMK1 | 0.62044977 |
| 82 | GRK1 | 0.61871381 |
| 83 | BRSK1 | 0.59430681 |
| 84 | SIK3 | 0.58498172 |
| 85 | SGK1 | 0.57546856 |
| 86 | NEK1 | 0.53913770 |
| 87 | MAP2K6 | 0.53319858 |
| 88 | RPS6KA3 | 0.50823879 |
| 89 | CAMK2G | 0.47852819 |
| 90 | CAMK4 | 0.47828609 |
| 91 | MAPK10 | 0.47743908 |
| 92 | TRIM28 | 0.47571363 |
| 93 | MAPK12 | 0.46676545 |
| 94 | NEK6 | 0.46089175 |
| 95 | ADRBK1 | 0.44992035 |
| 96 | PDK1 | 0.44830016 |
| 97 | TNK2 | 0.44781910 |
| 98 | MAPKAPK5 | 0.44483860 |
| 99 | CSNK1G1 | 0.43019208 |
| 100 | FYN | 0.41943707 |
| 101 | PRKCE | 0.40571796 |
| 102 | ARAF | 0.39852399 |
| 103 | CAMK1D | 0.38426993 |
| 104 | WNK3 | 0.37931928 |
| 105 | MAP3K6 | 0.37553283 |
| 106 | CAMK2B | 0.37500442 |
| 107 | PRKACA | 0.37075695 |
| 108 | MAPK8 | 0.36873896 |
| 109 | CSNK1D | 0.36519304 |
| 110 | PRKAA1 | 0.35587927 |
| 111 | PRKCA | 0.34499989 |
| 112 | CSNK1G3 | 0.33879916 |
| 113 | PDPK1 | 0.33683819 |
| 114 | STK39 | 0.33468709 |
| 115 | MAP3K1 | 0.33380138 |
| 116 | PKN1 | 0.33263169 |
| 117 | CAMK2D | 0.33223025 |
| 118 | ERBB2 | 0.33120718 |
| 119 | PRKCB | 0.32720850 |
| 120 | CSNK1A1L | 0.32427461 |
| 121 | CSNK1A1 | 0.31825284 |
| 122 | CSNK1E | 0.31495895 |
| 123 | FER | 0.31037676 |
| 124 | MAPK9 | 0.30395522 |
| 125 | CCNB1 | 0.29832314 |
| 126 | GSK3B | 0.28951438 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.63050370 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.54198409 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.61106026 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.60943806 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.58047371 |
| 6 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.52266326 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.46848664 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.46329744 |
| 9 | Long-term potentiation_Homo sapiens_hsa04720 | 2.36354643 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 2.30055447 |
| 11 | Insulin secretion_Homo sapiens_hsa04911 | 2.09576388 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.08712709 |
| 13 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.05117961 |
| 14 | Salivary secretion_Homo sapiens_hsa04970 | 2.03175400 |
| 15 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.89534805 |
| 16 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.87727653 |
| 17 | Taste transduction_Homo sapiens_hsa04742 | 1.83294558 |
| 18 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.80218723 |
| 19 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.73395748 |
| 20 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.69346156 |
| 21 | Long-term depression_Homo sapiens_hsa04730 | 1.59237432 |
| 22 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.52073326 |
| 23 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.49397150 |
| 24 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.48065829 |
| 25 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.47999936 |
| 26 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.44853387 |
| 27 | Cocaine addiction_Homo sapiens_hsa05030 | 1.42371346 |
| 28 | Gap junction_Homo sapiens_hsa04540 | 1.38961327 |
| 29 | Axon guidance_Homo sapiens_hsa04360 | 1.37502833 |
| 30 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.36546105 |
| 31 | Renin secretion_Homo sapiens_hsa04924 | 1.36518698 |
| 32 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.34490632 |
| 33 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.28642170 |
| 34 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.23159336 |
| 35 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.23061756 |
| 36 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.19605972 |
| 37 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.18664633 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 1.18156392 |
| 39 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.17494625 |
| 40 | Glioma_Homo sapiens_hsa05214 | 1.16659755 |
| 41 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.12236522 |
| 42 | Melanogenesis_Homo sapiens_hsa04916 | 1.01829041 |
| 43 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.99144845 |
| 44 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.97750856 |
| 45 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.96256939 |
| 46 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.95327365 |
| 47 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.93119896 |
| 48 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.90249706 |
| 49 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.90181373 |
| 50 | Endometrial cancer_Homo sapiens_hsa05213 | 0.89727669 |
| 51 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.89364805 |
| 52 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.87633704 |
| 53 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.87532586 |
| 54 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.82017076 |
| 55 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.81982749 |
| 56 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.80735991 |
| 57 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.80446483 |
| 58 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.77899998 |
| 59 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.77898262 |
| 60 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.76322674 |
| 61 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.76111615 |
| 62 | Alzheimers disease_Homo sapiens_hsa05010 | 0.75528356 |
| 63 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.73966569 |
| 64 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.72705938 |
| 65 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.72213823 |
| 66 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.71477682 |
| 67 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.70700708 |
| 68 | Parkinsons disease_Homo sapiens_hsa05012 | 0.69318702 |
| 69 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.66987810 |
| 70 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.65384568 |
| 71 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.64237596 |
| 72 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.63554778 |
| 73 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.63155841 |
| 74 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.61715751 |
| 75 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.61435468 |
| 76 | Endocytosis_Homo sapiens_hsa04144 | 0.61237284 |
| 77 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.61160925 |
| 78 | Colorectal cancer_Homo sapiens_hsa05210 | 0.60381816 |
| 79 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.60053809 |
| 80 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.59271275 |
| 81 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.58697041 |
| 82 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.58379069 |
| 83 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.58142766 |
| 84 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.57850786 |
| 85 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.56722355 |
| 86 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.56584283 |
| 87 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.55754858 |
| 88 | Circadian rhythm_Homo sapiens_hsa04710 | 0.55399023 |
| 89 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.54538014 |
| 90 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.52752769 |
| 91 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.51079587 |
| 92 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.50550635 |
| 93 | Alcoholism_Homo sapiens_hsa05034 | 0.50507125 |
| 94 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.50244228 |
| 95 | Bile secretion_Homo sapiens_hsa04976 | 0.50022448 |
| 96 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.49754848 |
| 97 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.48896609 |
| 98 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.47996776 |
| 99 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.47981810 |
| 100 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.46768895 |
| 101 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.44445773 |
| 102 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.43113445 |
| 103 | ABC transporters_Homo sapiens_hsa02010 | 0.42857493 |
| 104 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.41909959 |
| 105 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.40422531 |
| 106 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.40389081 |
| 107 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.39717754 |
| 108 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.38880323 |
| 109 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.38872405 |
| 110 | Prion diseases_Homo sapiens_hsa05020 | 0.37020091 |
| 111 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.35293026 |
| 112 | Huntingtons disease_Homo sapiens_hsa05016 | 0.34542542 |
| 113 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.33687738 |
| 114 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.32991475 |
| 115 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.32359848 |
| 116 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.31943935 |
| 117 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.31587009 |
| 118 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.31413504 |
| 119 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.31144008 |
| 120 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.30940336 |
| 121 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.30889746 |
| 122 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.30826965 |
| 123 | Mineral absorption_Homo sapiens_hsa04978 | 0.22263576 |

