MAST4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.53222668
2regulation of endothelial cell differentiation (GO:0045601)3.45392750
3desmosome organization (GO:0002934)3.29832069
4endothelium development (GO:0003158)3.25071265
5membrane repolarization during action potential (GO:0086011)3.21558050
6artery development (GO:0060840)3.19849618
7central nervous system myelination (GO:0022010)3.15688860
8axon ensheathment in central nervous system (GO:0032291)3.15688860
9positive regulation of glomerulus development (GO:0090193)3.15378370
10keratinization (GO:0031424)3.12677998
11regulation of female receptivity (GO:0045924)3.07991678
12blood vessel maturation (GO:0001955)3.01619547
13establishment of skin barrier (GO:0061436)2.99523699
14positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.97574693
15cardiac muscle cell action potential (GO:0086001)2.97098949
16cardiac muscle cell action potential involved in contraction (GO:0086002)2.96634292
17hemidesmosome assembly (GO:0031581)2.94596282
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88647911
19intestinal epithelial cell development (GO:0060576)2.84559009
20regulation of membrane repolarization (GO:0060306)2.84273908
21positive regulation of endothelial cell differentiation (GO:0045603)2.82384042
22behavioral response to nicotine (GO:0035095)2.81204427
23regulation of glomerulus development (GO:0090192)2.79104796
24organ formation (GO:0048645)2.76447998
25interkinetic nuclear migration (GO:0022027)2.74619696
26smooth muscle tissue development (GO:0048745)2.72653870
27cAMP catabolic process (GO:0006198)2.67275279
28limb bud formation (GO:0060174)2.65523138
29membrane repolarization (GO:0086009)2.58225972
30regulation of skeletal muscle contraction (GO:0014819)2.55974809
31regulation of axon extension involved in axon guidance (GO:0048841)2.51590065
32lymph vessel development (GO:0001945)2.49820879
33multicellular organismal signaling (GO:0035637)2.48818234
34cyclic nucleotide catabolic process (GO:0009214)2.47336572
35eye photoreceptor cell differentiation (GO:0001754)2.42756759
36photoreceptor cell differentiation (GO:0046530)2.42756759
37negative regulation of systemic arterial blood pressure (GO:0003085)2.42482154
38pharyngeal system development (GO:0060037)2.42286171
39peptidyl-tyrosine autophosphorylation (GO:0038083)2.41784258
40glomerular visceral epithelial cell development (GO:0072015)2.41725221
41response to lipoprotein particle (GO:0055094)2.41587149
42membrane depolarization during action potential (GO:0086010)2.40780934
43endothelial tube morphogenesis (GO:0061154)2.40426631
44morphogenesis of an endothelium (GO:0003159)2.40426631
45endoderm formation (GO:0001706)2.39535024
46DNA deamination (GO:0045006)2.39441616
47negative regulation of axon extension involved in axon guidance (GO:0048843)2.38849676
48inositol phosphate-mediated signaling (GO:0048016)2.35908707
49nephron tubule morphogenesis (GO:0072078)2.35667678
50nephron epithelium morphogenesis (GO:0072088)2.35667678
51regulation of mesoderm development (GO:2000380)2.35496382
52positive regulation of potassium ion transmembrane transport (GO:1901381)2.35485319
53positive regulation of phosphatase activity (GO:0010922)2.35266294
54negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.33234212
55female mating behavior (GO:0060180)2.32732568
56ventricular cardiac muscle cell action potential (GO:0086005)2.32283542
57cellular potassium ion homeostasis (GO:0030007)2.32122369
58regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.31988915
59regulation of axon guidance (GO:1902667)2.31986656
60regulation of cell proliferation involved in kidney development (GO:1901722)2.31652679
61regulation of sequestering of triglyceride (GO:0010889)2.31590462
62action potential (GO:0001508)2.31040326
63negative regulation of cytosolic calcium ion concentration (GO:0051481)2.29605391
64regulation of water loss via skin (GO:0033561)2.29096078
65detection of calcium ion (GO:0005513)2.29070845
66cerebral cortex radially oriented cell migration (GO:0021799)2.25461491
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.24388851
68mesenchymal cell differentiation (GO:0048762)2.22901983
69positive regulation of protein kinase C signaling (GO:0090037)2.21338162
70histone H3-K4 trimethylation (GO:0080182)2.21093279
71endothelial cell differentiation (GO:0045446)2.19538559
72renal tubule morphogenesis (GO:0061333)2.17319813
73angiogenesis involved in wound healing (GO:0060055)2.17111900
74myelination in peripheral nervous system (GO:0022011)2.17108510
75peripheral nervous system axon ensheathment (GO:0032292)2.17108510
76phosphatidylinositol acyl-chain remodeling (GO:0036149)2.16432020
77regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.16147322
78magnesium ion transport (GO:0015693)2.16059512
79positive regulation of fatty acid oxidation (GO:0046321)2.14022223
80auditory receptor cell differentiation (GO:0042491)2.13795604
81positive regulation of action potential (GO:0045760)2.13250535
82parturition (GO:0007567)2.13166219
83glomerular epithelial cell development (GO:0072310)2.12983368
84epithelial cell fate commitment (GO:0072148)2.12046871
85atrioventricular valve morphogenesis (GO:0003181)2.10973045
86positive regulation of cardiac muscle cell differentiation (GO:2000727)2.10901069
87negative regulation of axon guidance (GO:1902668)2.10869932
88myoblast fusion (GO:0007520)2.10620872
89negative regulation of activin receptor signaling pathway (GO:0032926)2.10278767
90primary amino compound metabolic process (GO:1901160)2.09216206
91dendrite morphogenesis (GO:0048813)2.09016780
92mesodermal cell differentiation (GO:0048333)2.08822472
93serotonin metabolic process (GO:0042428)2.08679165
94regulation of type B pancreatic cell apoptotic process (GO:2000674)2.08570379
95neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.08082060
96regulation of alkaline phosphatase activity (GO:0010692)2.07908284
97regulation of action potential (GO:0098900)2.07618380
98retina vasculature morphogenesis in camera-type eye (GO:0061299)2.06874878
99axonal fasciculation (GO:0007413)2.06444709
100regulation of potassium ion transmembrane transport (GO:1901379)2.05473490
101chondrocyte development (GO:0002063)2.05079496
102axoneme assembly (GO:0035082)2.05069839
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.04327179
104negative regulation of protein localization to cell surface (GO:2000009)2.04244304
105purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.03919207
1063-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.03919207
107cAMP metabolic process (GO:0046058)2.03450583
108regulation of secondary heart field cardioblast proliferation (GO:0003266)2.03378595
109regulation of cardioblast proliferation (GO:0003264)2.03378595
110neuron remodeling (GO:0016322)2.03164870
111plasma membrane repair (GO:0001778)2.03031022
112glandular epithelial cell differentiation (GO:0002067)2.02290885
113relaxation of cardiac muscle (GO:0055119)2.02244130
114adaptation of signaling pathway (GO:0023058)2.02213511
115negative regulation of actin filament bundle assembly (GO:0032232)2.02178461
116regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.02124880
117negative regulation of mast cell activation (GO:0033004)2.02123948
118anatomical structure arrangement (GO:0048532)2.01795180
119extracellular matrix assembly (GO:0085029)2.01672944
120cardiac conduction (GO:0061337)1.99999999
121mesenchyme morphogenesis (GO:0072132)1.99156559
122regulation of acrosome reaction (GO:0060046)1.99107726
123aorta morphogenesis (GO:0035909)1.98384564
124endocardial cushion development (GO:0003197)1.98129784
125negative regulation of hormone biosynthetic process (GO:0032353)1.97776440
126sarcoplasmic reticulum calcium ion transport (GO:0070296)1.97713326
127regulation of sodium ion transmembrane transporter activity (GO:2000649)1.97574618
128cellular response to ATP (GO:0071318)1.97487771
129negative regulation of synaptic transmission, GABAergic (GO:0032229)1.97263736
130venous blood vessel morphogenesis (GO:0048845)1.97172992
131nerve growth factor signaling pathway (GO:0038180)1.96826025
132ear development (GO:0043583)1.96450412
133ganglion development (GO:0061548)1.96340070
134positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003571.96086195
135cardiac myofibril assembly (GO:0055003)1.96080356
136regulation of heart rate (GO:0002027)1.95642906
137bundle of His cell to Purkinje myocyte communication (GO:0086069)1.95546432
138positive regulation of bone mineralization (GO:0030501)1.95357169
139cerebellar Purkinje cell differentiation (GO:0021702)1.94804908
140lymphangiogenesis (GO:0001946)1.94509076
141myelination (GO:0042552)1.94026397
142negative regulation of neurotransmitter secretion (GO:0046929)1.93032969
143gland morphogenesis (GO:0022612)1.92180476
144myofibril assembly (GO:0030239)1.91799353
145regulation of cardiac muscle cell differentiation (GO:2000725)1.91459175
146Golgi to endosome transport (GO:0006895)1.91341584
147apical protein localization (GO:0045176)1.91306517
148ionotropic glutamate receptor signaling pathway (GO:0035235)1.90695696
149axon ensheathment (GO:0008366)1.90643676
150ensheathment of neurons (GO:0007272)1.90643676
151negative regulation of osteoblast proliferation (GO:0033689)1.89991147
152negative regulation of keratinocyte proliferation (GO:0010839)1.89862937
153protein targeting to Golgi (GO:0000042)1.89790265
154heart valve morphogenesis (GO:0003179)1.89788584
155regulation of heart rate by cardiac conduction (GO:0086091)1.89685575
156asymmetric protein localization (GO:0008105)1.89588567
157retrograde transport, vesicle recycling within Golgi (GO:0000301)1.88929652
158syncytium formation by plasma membrane fusion (GO:0000768)1.88908349
159insulin-like growth factor receptor signaling pathway (GO:0048009)1.88904017
160potassium ion import (GO:0010107)1.88884088
161neuron recognition (GO:0008038)1.88611759
162positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.88479678
163regulation of pigment cell differentiation (GO:0050932)1.87770854
164negative regulation of Rho protein signal transduction (GO:0035024)1.87487284
165regulation of p38MAPK cascade (GO:1900744)1.86774696
166dendritic spine morphogenesis (GO:0060997)1.86702694
167dendritic spine organization (GO:0097061)1.85961137
168cell communication involved in cardiac conduction (GO:0086065)1.84891564
169cytoskeletal anchoring at plasma membrane (GO:0007016)1.82857927
170heart morphogenesis (GO:0003007)1.82729638
171response to monoamine (GO:0071867)1.82072530
172response to catecholamine (GO:0071869)1.82072530
173sequestering of extracellular ligand from receptor (GO:0035581)1.81902000
174positive regulation of biomineral tissue development (GO:0070169)1.81743295
175camera-type eye morphogenesis (GO:0048593)1.81712898
176establishment of protein localization to Golgi (GO:0072600)1.80536349
177regulation of mesenchymal cell proliferation (GO:0010464)1.79529897
178negative regulation of neurotransmitter transport (GO:0051589)1.79430404
179neuron projection extension involved in neuron projection guidance (GO:1902284)1.79304469
180axon extension involved in axon guidance (GO:0048846)1.79304469
181endocardial cushion morphogenesis (GO:0003203)1.78976349
182long-chain fatty acid biosynthetic process (GO:0042759)1.78755023
183regulation of osteoblast proliferation (GO:0033688)1.78742677
184glutamate receptor signaling pathway (GO:0007215)1.78184560
185positive regulation of mesenchymal cell proliferation (GO:0002053)1.77697565
186presynaptic membrane assembly (GO:0097105)1.77583776
187import into cell (GO:0098657)1.77460110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.25494732
2GBX2_23144817_ChIP-Seq_PC3_Human2.93388206
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73845000
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.51013499
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10563655
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07872115
7VDR_22108803_ChIP-Seq_LS180_Human2.06915133
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.06111419
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.05486927
10* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.02474419
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02454458
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00965266
13EED_16625203_ChIP-ChIP_MESCs_Mouse1.98324558
14EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93974639
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93974639
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90629458
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90590078
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89877282
19AR_21572438_ChIP-Seq_LNCaP_Human1.86644956
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84166414
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84070068
22* EZH2_27304074_Chip-Seq_ESCs_Mouse1.79619553
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75181145
24DROSHA_22980978_ChIP-Seq_HELA_Human1.71679546
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71666520
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.68233847
27* RNF2_27304074_Chip-Seq_ESCs_Mouse1.66360387
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.66327052
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64606501
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62751878
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57913802
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57540782
33* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57122630
34AHR_22903824_ChIP-Seq_MCF-7_Human1.56481366
35TP53_16413492_ChIP-PET_HCT116_Human1.53559155
36* EZH2_27294783_Chip-Seq_ESCs_Mouse1.52702556
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.51538156
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49358699
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46960556
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.45241684
41* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43659614
42* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42466691
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.40987343
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40959977
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40322650
46TP53_18474530_ChIP-ChIP_U2OS_Human1.36603372
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34964187
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34031726
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32593248
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32026116
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31942441
52* P300_19829295_ChIP-Seq_ESCs_Human1.30542060
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26792337
54CJUN_26792858_Chip-Seq_BT549_Human1.25683738
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25112021
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24683343
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24359051
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23662079
59* STAT3_23295773_ChIP-Seq_U87_Human1.23574267
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23320109
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21525360
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.20618758
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.20001223
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19855025
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19855025
66* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19584112
67RXR_22108803_ChIP-Seq_LS180_Human1.19510103
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19495553
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.17449570
70* GATA2_21666600_ChIP-Seq_HMVEC_Human1.17141351
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17130394
72TAF15_26573619_Chip-Seq_HEK293_Human1.16154145
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15584329
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15228632
75* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12967937
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12224901
77RNF2_27304074_Chip-Seq_NSC_Mouse1.12074972
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11122214
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10494315
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.09593211
81* TCF4_23295773_ChIP-Seq_U87_Human1.08551530
82AR_25329375_ChIP-Seq_VCAP_Human1.07668412
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.06762044
84* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06623939
85REST_21632747_ChIP-Seq_MESCs_Mouse1.06001897
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04337899
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.03973467
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.03291798
89ZNF274_21170338_ChIP-Seq_K562_Hela1.02463535
90* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02045383
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01116973
92BCAT_22108803_ChIP-Seq_LS180_Human1.01099483
93* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00859128
94* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00684094
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00452255
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00452255
97ISL1_27105846_Chip-Seq_CPCs_Mouse0.99610729
98NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99596314
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99304285
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98967745
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.98901683
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98828464
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98787355
104* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98468394
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.98361875
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98342366
107ER_23166858_ChIP-Seq_MCF-7_Human0.98240222
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.98189326
109* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97368407
110* RUNX2_22187159_ChIP-Seq_PCA_Human0.97240627
111* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96897426
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.96556597
113* RING1B_27294783_Chip-Seq_NPCs_Mouse0.95606053
114TCF4_18268006_ChIP-ChIP_LS174T_Human0.95512931
115CDX2_22108803_ChIP-Seq_LS180_Human0.95349454
116* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94932145
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94302319
118* TP63_23658742_ChIP-Seq_EP156T_Human0.94236916
119RING1B_27294783_Chip-Seq_ESCs_Mouse0.93957486
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.93504970
121* TCF4_22108803_ChIP-Seq_LS180_Human0.92796595
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91718035
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91646727
124CBP_20019798_ChIP-Seq_JUKART_Human0.91646727
125SMAD4_21741376_ChIP-Seq_EPCs_Human0.90020483
126* FLI1_21867929_ChIP-Seq_TH2_Mouse0.88165181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology2.95578189
2MP0002138_abnormal_hepatobiliary_system2.52550764
3MP0000383_abnormal_hair_follicle2.26206940
4MP0009780_abnormal_chondrocyte_physiolo2.18194374
5MP0005670_abnormal_white_adipose2.14384523
6MP0005623_abnormal_meninges_morphology2.10404739
7MP0005171_absent_coat_pigmentation2.09308935
8MP0003646_muscle_fatigue2.02392127
9MP0005503_abnormal_tendon_morphology2.01589270
10MP0004130_abnormal_muscle_cell1.99899301
11MP0005275_abnormal_skin_tensile1.99795814
12MP0000566_synostosis1.94025392
13MP0001299_abnormal_eye_distance/1.91437340
14MP0003950_abnormal_plasma_membrane1.89968641
15MP0004272_abnormal_basement_membrane1.89416564
16MP0010678_abnormal_skin_adnexa1.89111197
17MP0003879_abnormal_hair_cell1.85015774
18MP0000751_myopathy1.78134324
19MP0004145_abnormal_muscle_electrophysio1.74698224
20MP0008438_abnormal_cutaneous_collagen1.74650380
21MP0003045_fibrosis1.70448040
22MP0001346_abnormal_lacrimal_gland1.68982020
23MP0002877_abnormal_melanocyte_morpholog1.68816453
24MP0008775_abnormal_heart_ventricle1.62522647
25MP0005167_abnormal_blood-brain_barrier1.61699083
26MP0004270_analgesia1.60382030
27MP0003941_abnormal_skin_development1.59655897
28MP0001879_abnormal_lymphatic_vessel1.58651866
29MP0003195_calcinosis1.57194128
30MP0004859_abnormal_synaptic_plasticity1.54203040
31MP0000569_abnormal_digit_pigmentation1.49910262
32MP0003122_maternal_imprinting1.49875626
33MP0005645_abnormal_hypothalamus_physiol1.47803754
34MP0009250_abnormal_appendicular_skeleto1.47388464
35MP0000465_gastrointestinal_hemorrhage1.43324849
36MP0010368_abnormal_lymphatic_system1.40756328
37MP0003724_increased_susceptibility_to1.38671262
38MP0005409_darkened_coat_color1.38531810
39MP0002108_abnormal_muscle_morphology1.38412785
40MP0003880_abnormal_central_pattern1.38204635
41MP0000762_abnormal_tongue_morphology1.34816860
42MP0001188_hyperpigmentation1.34568504
43MP0000579_abnormal_nail_morphology1.33811904
44MP0003385_abnormal_body_wall1.31452967
45MP0003279_aneurysm1.28888335
46MP0005646_abnormal_pituitary_gland1.28622508
47MP0002060_abnormal_skin_morphology1.27101611
48MP0000749_muscle_degeneration1.26814486
49MP0005551_abnormal_eye_electrophysiolog1.26130025
50MP0005508_abnormal_skeleton_morphology1.25761988
51MP0002234_abnormal_pharynx_morphology1.24451718
52MP0001968_abnormal_touch/_nociception1.22569812
53MP0000230_abnormal_systemic_arterial1.22369281
54MP0004484_altered_response_of1.22015363
55MP0005595_abnormal_vascular_smooth1.21703847
56MP0003011_delayed_dark_adaptation1.20851760
57MP0001765_abnormal_ion_homeostasis1.20653761
58MP0001485_abnormal_pinna_reflex1.19733234
59MP0002896_abnormal_bone_mineralization1.19348061
60MP0000778_abnormal_nervous_system1.18201707
61MP0004381_abnormal_hair_follicle1.17265995
62MP0002098_abnormal_vibrissa_morphology1.17051423
63MP0004043_abnormal_pH_regulation1.15794677
64MP0003828_pulmonary_edema1.15632275
65MP0001486_abnormal_startle_reflex1.15620975
66MP0002909_abnormal_adrenal_gland1.14641772
67MP0006276_abnormal_autonomic_nervous1.14507069
68MP0003787_abnormal_imprinting1.14385962
69MP0004036_abnormal_muscle_relaxation1.14318459
70MP0002009_preneoplasia1.13858548
71MP0004084_abnormal_cardiac_muscle1.13768267
72MP0003091_abnormal_cell_migration1.11587941
73MP0003635_abnormal_synaptic_transmissio1.11295927
74MP0000920_abnormal_myelination1.10386418
75MP0004215_abnormal_myocardial_fiber1.09229870
76MP0004885_abnormal_endolymph1.09146893
77MP0000467_abnormal_esophagus_morphology1.09139108
78MP0000013_abnormal_adipose_tissue1.08812784
79MP0002160_abnormal_reproductive_system1.07988848
80MP0002177_abnormal_outer_ear1.07102755
81MP0004085_abnormal_heartbeat1.07021961
82MP0001502_abnormal_circadian_rhythm1.06558946
83MP0000767_abnormal_smooth_muscle1.06180383
84MP0000003_abnormal_adipose_tissue1.04579383
85MP0004134_abnormal_chest_morphology1.04517977
86MP0003755_abnormal_palate_morphology1.03021910
87MP0009053_abnormal_anal_canal1.02779695
88MP0000631_abnormal_neuroendocrine_gland1.01661061
89MP0006138_congestive_heart_failure1.00808029
90MP0001984_abnormal_olfaction1.00742834
91MP0000733_abnormal_muscle_development1.00713327
92MP0000647_abnormal_sebaceous_gland1.00494402
93MP0003136_yellow_coat_color0.99240423
94MP0010030_abnormal_orbit_morphology0.96733401
95MP0001440_abnormal_grooming_behavior0.96358355
96MP0005620_abnormal_muscle_contractility0.94916459
97MP0002102_abnormal_ear_morphology0.94573224
98MP0000678_abnormal_parathyroid_gland0.94282010
99MP0000427_abnormal_hair_cycle0.94253419
100MP0004742_abnormal_vestibular_system0.92773381
101MP0000163_abnormal_cartilage_morphology0.92640764
102MP0001177_atelectasis0.91680968
103MP0002272_abnormal_nervous_system0.91014664
104MP0002972_abnormal_cardiac_muscle0.90946720
105MP0003935_abnormal_craniofacial_develop0.90475678
106MP0002254_reproductive_system_inflammat0.90331860
107MP0010386_abnormal_urinary_bladder0.90025166
108MP0001958_emphysema0.89935547
109MP0002116_abnormal_craniofacial_bone0.89680015
110MP0002295_abnormal_pulmonary_circulatio0.88644904
111MP0002638_abnormal_pupillary_reflex0.88484005
112MP0005369_muscle_phenotype0.88435894
113MP0002796_impaired_skin_barrier0.87902798
114MP0000049_abnormal_middle_ear0.87826777
115MP0003937_abnormal_limbs/digits/tail_de0.87570218
116MP0002233_abnormal_nose_morphology0.86834441
117MP0009745_abnormal_behavioral_response0.86072609
118MP0005367_renal/urinary_system_phenotyp0.85749432
119MP0000516_abnormal_urinary_system0.85749432
120MP0001501_abnormal_sleep_pattern0.85625538
121MP0005375_adipose_tissue_phenotype0.85500916
122MP0001544_abnormal_cardiovascular_syste0.85415222
123MP0005385_cardiovascular_system_phenoty0.85415222
124MP0002127_abnormal_cardiovascular_syste0.84382635
125MP0002837_dystrophic_cardiac_calcinosis0.84302754
126MP0003119_abnormal_digestive_system0.83968018
127MP0003283_abnormal_digestive_organ0.82573405
128MP0009046_muscle_twitch0.82127793
129MP0002938_white_spotting0.81832513
130MP0005174_abnormal_tail_pigmentation0.81231839
131MP0003566_abnormal_cell_adhesion0.80938585
132MP0002063_abnormal_learning/memory/cond0.80426860
133MP0010329_abnormal_lipoprotein_level0.80283882
134MP0002064_seizures0.80106342
135MP0004087_abnormal_muscle_fiber0.79671924
136MP0009384_cardiac_valve_regurgitation0.78240946
137MP0002734_abnormal_mechanical_nocicepti0.77933785
138MP0003137_abnormal_impulse_conducting0.77776856
139MP0010771_integument_phenotype0.77512127
140MP0004782_abnormal_surfactant_physiolog0.76754387
141MP0006072_abnormal_retinal_apoptosis0.76492497
142MP0001944_abnormal_pancreas_morphology0.76217114
143MP0003638_abnormal_response/metabolism_0.75498908
144MP0004142_abnormal_muscle_tone0.75288621
145MP0001986_abnormal_taste_sensitivity0.74403554
146MP0005389_reproductive_system_phenotype0.73820278
147MP0002572_abnormal_emotion/affect_behav0.72619932
148MP0006292_abnormal_olfactory_placode0.72454822
149MP0008877_abnormal_DNA_methylation0.72100531
150MP0001756_abnormal_urination0.71070249
151MP0002933_joint_inflammation0.67305897

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)3.36264210
2Clumsiness (HP:0002312)3.22125475
3Abnormality of secondary sexual hair (HP:0009888)3.18545557
4Abnormality of the axillary hair (HP:0100134)3.18545557
5Atrophic scars (HP:0001075)3.18138372
6Abnormality of the renal cortex (HP:0011035)2.92049645
7Aplasia involving bones of the upper limbs (HP:0009823)2.88631644
8Aplasia of the phalanges of the hand (HP:0009802)2.88631644
9Aplasia involving bones of the extremities (HP:0009825)2.88631644
10Megalencephaly (HP:0001355)2.86178155
11Hypoplastic ischia (HP:0003175)2.85247904
12Fragile nails (HP:0001808)2.81303321
13Alopecia of scalp (HP:0002293)2.76399945
14Abnormality of nail color (HP:0100643)2.73703741
15Oligodontia (HP:0000677)2.71800909
16Hypotrichosis (HP:0001006)2.70880779
17Plantar hyperkeratosis (HP:0007556)2.69165857
18Abnormality of the renal medulla (HP:0100957)2.68236435
19Right ventricular cardiomyopathy (HP:0011663)2.67121660
20Broad metatarsal (HP:0001783)2.61588627
21Nephronophthisis (HP:0000090)2.59121902
22Abnormality of the nasal septum (HP:0000419)2.59120264
23Abnormality of the ischium (HP:0003174)2.58014252
24Congenital, generalized hypertrichosis (HP:0004540)2.57102563
25Aplasia cutis congenita (HP:0001057)2.53481083
26Lip pit (HP:0100267)2.51578701
27Follicular hyperkeratosis (HP:0007502)2.50766542
28Hypoplasia of the iris (HP:0007676)2.49457670
29Woolly hair (HP:0002224)2.46822629
30Congenital stationary night blindness (HP:0007642)2.46001777
31Polydipsia (HP:0001959)2.45940888
32Abnormal drinking behavior (HP:0030082)2.45940888
33Palmoplantar hyperkeratosis (HP:0000972)2.44836586
34Hyporeflexia of lower limbs (HP:0002600)2.44765989
35Milia (HP:0001056)2.43259591
36Pancreatic cysts (HP:0001737)2.40602736
37Ventricular fibrillation (HP:0001663)2.37966524
38Portal hypertension (HP:0001409)2.36874201
39Prolonged QT interval (HP:0001657)2.35657316
40Hemiparesis (HP:0001269)2.31560900
41Atrial fibrillation (HP:0005110)2.31429868
42Premature rupture of membranes (HP:0001788)2.30412237
43Adactyly (HP:0009776)2.27594546
44Bell-shaped thorax (HP:0001591)2.25797077
45Alacrima (HP:0000522)2.22952246
46Bulbous nose (HP:0000414)2.22584964
47Thyroid-stimulating hormone excess (HP:0002925)2.21929146
48Distal lower limb amyotrophy (HP:0008944)2.20487370
49Abnormality of the renal collecting system (HP:0004742)2.19965675
50Thick nail (HP:0001805)2.19296687
51Hypoplasia of the uterus (HP:0000013)2.18907823
52Abnormality of renin-angiotensin system (HP:0000847)2.18354137
53Tubular atrophy (HP:0000092)2.17518745
54Palmar hyperkeratosis (HP:0010765)2.17235001
55Shallow orbits (HP:0000586)2.16606466
56Ventricular arrhythmia (HP:0004308)2.16208205
57Gaze-evoked nystagmus (HP:0000640)2.16207954
58Erythroderma (HP:0001019)2.14936030
59Absent eyebrow (HP:0002223)2.14202499
60Bronchomalacia (HP:0002780)2.14096456
61Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.13197207
62Bradycardia (HP:0001662)2.12269915
63Abnormality of incisor morphology (HP:0011063)2.12262155
64Lower limb amyotrophy (HP:0007210)2.11895108
65Congenital sensorineural hearing impairment (HP:0008527)2.11174598
66Primary atrial arrhythmia (HP:0001692)2.09906500
67Sudden death (HP:0001699)2.09886531
68Anterior segment dysgenesis (HP:0007700)2.08182619
69Abnormality of the calf musculature (HP:0001430)2.07731148
70Bundle branch block (HP:0011710)2.06812450
71Abnormality of the hepatic vasculature (HP:0006707)2.05011172
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.03596996
73Focal seizures (HP:0007359)2.03106741
74Renal cortical cysts (HP:0000803)2.02395042
75Furrowed tongue (HP:0000221)2.01747135
76Cutaneous finger syndactyly (HP:0010554)2.00740685
77Aplasia/Hypoplasia of the hallux (HP:0008362)1.98737871
78Mixed hearing impairment (HP:0000410)1.98726130
79Abnormal EKG (HP:0003115)1.98496055
80Diplopia (HP:0000651)1.98292266
81Abnormality of binocular vision (HP:0011514)1.98292266
82Muscle fiber splitting (HP:0003555)1.97583913
83Limited hip movement (HP:0008800)1.97499584
84Febrile seizures (HP:0002373)1.97376472
85Onycholysis (HP:0001806)1.96940444
86Pancreatic fibrosis (HP:0100732)1.94408353
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94190935
88Abnormality of the right ventricle (HP:0001707)1.93940098
89Molar tooth sign on MRI (HP:0002419)1.93902056
90Abnormality of midbrain morphology (HP:0002418)1.93902056
91Focal motor seizures (HP:0011153)1.93551006
92Broad-based gait (HP:0002136)1.90165302
93Chronic hepatic failure (HP:0100626)1.90031176
94Supraventricular arrhythmia (HP:0005115)1.89056736
95Hypoplasia of dental enamel (HP:0006297)1.88898811
96Onion bulb formation (HP:0003383)1.87406180
97Parakeratosis (HP:0001036)1.87207110
98Decreased lacrimation (HP:0000633)1.86961306
99Supraventricular tachycardia (HP:0004755)1.86829212
100Submucous cleft hard palate (HP:0000176)1.86809485
101Scapular winging (HP:0003691)1.86322275
102Abnormality of the proximal phalanges of the hand (HP:0009834)1.86148713
103Corneal erosion (HP:0200020)1.85374992
104Vascular calcification (HP:0004934)1.84164387
105Genetic anticipation (HP:0003743)1.84054006
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83851787
107Hamartoma of the eye (HP:0010568)1.83809394
108Aplasia/hypoplasia of the uterus (HP:0008684)1.83471874
109Fragile skin (HP:0001030)1.83208424
110Pigmentary retinal degeneration (HP:0001146)1.83074736
111Advanced eruption of teeth (HP:0006288)1.82668636
112Thickened helices (HP:0000391)1.82196701
113Type II lissencephaly (HP:0007260)1.81580344
114Syncope (HP:0001279)1.80952769
115Disproportionate short-trunk short stature (HP:0003521)1.80847280
116Calf muscle hypertrophy (HP:0008981)1.80830091
117Fair hair (HP:0002286)1.80315609
118Polyuria (HP:0000103)1.80145679
119Muscle hypertrophy of the lower extremities (HP:0008968)1.79748314
120Metabolic alkalosis (HP:0200114)1.79663327
121Morphological abnormality of the middle ear (HP:0008609)1.79213366
122Spontaneous hematomas (HP:0007420)1.79093472
123Abnormality of the middle phalanges of the toes (HP:0010183)1.78721081
124Ventricular tachycardia (HP:0004756)1.78184208
125Lymphangioma (HP:0100764)1.78066943
126Hyperlipoproteinemia (HP:0010980)1.78028904
127Overgrowth (HP:0001548)1.77902773
128Skin pits (HP:0100276)1.77586375
129Cystic liver disease (HP:0006706)1.76796326
130Hyperkalemia (HP:0002153)1.76343905
131Palpitations (HP:0001962)1.75663352
132Narrow palate (HP:0000189)1.74858304
133Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74792440
134Decreased circulating renin level (HP:0003351)1.73982227
135Abnormality of renal excretion (HP:0011036)1.73654541
136Arterial tortuosity (HP:0005116)1.72984083
137Heart block (HP:0012722)1.72984059
138Persistence of primary teeth (HP:0006335)1.72787297
139Macroorchidism (HP:0000053)1.72689924
140Cutaneous syndactyly (HP:0012725)1.72009357
141Widely spaced teeth (HP:0000687)1.71738454
142Hyperthyroidism (HP:0000836)1.71097196
143Vascular tortuosity (HP:0004948)1.71028709
144Abnormality of the nasolacrimal system (HP:0000614)1.70926459
145Short tibia (HP:0005736)1.70184835
146Short hallux (HP:0010109)1.70087637
147Depressed nasal tip (HP:0000437)1.69568758
148Hypoplastic labia majora (HP:0000059)1.68412318
149Spinal rigidity (HP:0003306)1.68393293
150Mildly elevated creatine phosphokinase (HP:0008180)1.68307354
151Natal tooth (HP:0000695)1.67499924
152Exercise-induced myalgia (HP:0003738)1.66645186
153Distal lower limb muscle weakness (HP:0009053)1.66532789
154Hip contracture (HP:0003273)1.64430699
155Corneal dystrophy (HP:0001131)1.64196053
156Coronal craniosynostosis (HP:0004440)1.64185551
157Increased connective tissue (HP:0009025)1.64044026
158Type 1 muscle fiber predominance (HP:0003803)1.62264064
159Buphthalmos (HP:0000557)1.60397334
160Nasolacrimal duct obstruction (HP:0000579)1.60255982
161White forelock (HP:0002211)1.59815176
162Pulmonary artery stenosis (HP:0004415)1.59590647
163Tracheomalacia (HP:0002779)1.59294708
164Difficulty running (HP:0009046)1.59109989
165Stomach cancer (HP:0012126)1.58930704
166Urethral obstruction (HP:0000796)1.57356835
167Abnormality of the lacrimal duct (HP:0011481)1.57305607
168Progressive cerebellar ataxia (HP:0002073)1.56117541
169Increased variability in muscle fiber diameter (HP:0003557)1.55869518
170Insulin-resistant diabetes mellitus (HP:0000831)1.55392060
171Exotropia (HP:0000577)1.51159491
172Aqueductal stenosis (HP:0002410)1.51045383
173Abnormality of the labia majora (HP:0012881)1.50370153
174Epileptic encephalopathy (HP:0200134)1.48731588
175Craniofacial hyperostosis (HP:0004493)1.48519960
176Abnormality of the parietal bone (HP:0002696)1.47550705
177Premature skin wrinkling (HP:0100678)1.46851274
178Periauricular skin pits (HP:0100277)1.46768937
179Preauricular pit (HP:0004467)1.46768937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.20355049
2INSRR2.65982993
3LATS12.43608850
4GRK12.40566353
5CAMK1G1.89900664
6ADRBK21.86599461
7DMPK1.85094039
8NTRK31.78941683
9MAPKAPK31.78220579
10KDR1.70498646
11PINK11.68038212
12FER1.66490793
13MAPK151.65200799
14TXK1.61859799
15CASK1.60837800
16PRPF4B1.59743326
17STK391.58267592
18WNK11.57948098
19FGFR21.56238784
20TNIK1.53861641
21MARK21.52559940
22CDC42BPA1.51382300
23PIK3CA1.51080870
24MYLK1.50447050
25NEK61.48391763
26DAPK21.45666420
27PRKD31.45633506
28EPHB11.42895154
29OBSCN1.41716519
30TIE11.40271735
31TGFBR11.38055691
32MUSK1.37992634
33TRPM71.36227203
34NUAK11.33466595
35SGK2231.33179458
36SGK4941.33179458
37PKN11.31361709
38EPHA31.31240493
39BRD41.31153086
40MAP4K21.29576268
41PAK31.26823352
42CAMK1D1.26050706
43MAPKAPK51.23155937
44MKNK21.23093962
45PRKCE1.22368809
46BCR1.20620320
47TTN1.17144967
48EPHB21.16385622
49EPHA41.16189788
50PHKG11.16098235
51PHKG21.16098235
52ZAK1.15546307
53BMPR1B1.14957728
54TGFBR21.09411118
55CAMK2D1.08836650
56HIPK21.08212855
57SIK31.04490572
58PRKD11.01787497
59FRK1.00891929
60SGK21.00712903
61WNK41.00065088
62CDK30.99770491
63SIK10.98815845
64PRKD20.96967137
65AKT30.95975161
66MAPK130.94606984
67TEC0.94593720
68RPS6KA20.93837654
69DDR20.93622701
70ADRBK10.92707665
71MAP2K20.92423087
72ERBB30.92341920
73CAMK2B0.91995264
74MAP2K60.88816621
75PTK20.83717536
76EPHA20.83200165
77TAOK30.82508435
78STK380.82201610
79BMPR20.81992049
80STK38L0.81555344
81MAP3K90.81079826
82GRK50.80672353
83PLK20.80250993
84MAPK70.78168990
85ITK0.78164837
86PTK2B0.77828216
87CAMK2A0.77631184
88UHMK10.77158944
89SGK10.77005034
90PDGFRA0.74906047
91MET0.74734883
92PDGFRB0.74492986
93SGK30.74401352
94OXSR10.73376922
95PRKCH0.73137584
96RIPK10.70899161
97MAP3K70.70214534
98FES0.67633779
99MAP3K20.66447084
100CSNK1A1L0.65938579
101DYRK1A0.65772623
102MAP2K10.65596070
103NTRK20.65511922
104NLK0.65413670
105IKBKB0.65233251
106STK110.64981368
107MAP3K40.64629315
108CAMK10.64215126
109PNCK0.60690237
110MAP3K140.59714186
111CDK50.59168265
112GRK70.59068189
113PRKG10.57182667
114ROCK10.57002414
115RPS6KA60.56242280
116PRKAA20.54670087
117MAP3K10.54517099
118ERBB20.53789075
119PRKCG0.53517726
120WNK30.53192484
121PRKAA10.53070062
122FLT30.53037430
123PRKACA0.52901072
124MARK10.52614768
125ROCK20.52219141
126NTRK10.51131984
127TNK20.50762468
128MAP2K70.50450258
129CAMKK20.50200804
130STK240.49634011
131CAMK40.49022718
132SIK20.48267178
133CHUK0.47253441
134MAP3K30.47230307
135MAPK120.46894750
136CAMK2G0.46422351
137ACVR1B0.46038698
138MKNK10.45636213
139FGFR30.45226048
140IGF1R0.45059048
141MAPK100.44454903
142LMTK20.43237191
143PIK3CG0.40918834
144KIT0.40632527

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39031896
2Linoleic acid metabolism_Homo sapiens_hsa005912.36042908
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90217647
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89965648
5Dilated cardiomyopathy_Homo sapiens_hsa054141.87659631
6ECM-receptor interaction_Homo sapiens_hsa045121.79591108
7Phototransduction_Homo sapiens_hsa047441.79412202
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75319891
9Insulin secretion_Homo sapiens_hsa049111.71990570
10Circadian entrainment_Homo sapiens_hsa047131.67719547
11Axon guidance_Homo sapiens_hsa043601.50083095
12Glutamatergic synapse_Homo sapiens_hsa047241.48539280
13ABC transporters_Homo sapiens_hsa020101.43836756
14Nicotine addiction_Homo sapiens_hsa050331.43805274
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35161517
16Morphine addiction_Homo sapiens_hsa050321.33603318
17Taste transduction_Homo sapiens_hsa047421.32797364
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31996753
19Serotonergic synapse_Homo sapiens_hsa047261.30727185
20Cocaine addiction_Homo sapiens_hsa050301.30463754
21Amphetamine addiction_Homo sapiens_hsa050311.30084371
22Circadian rhythm_Homo sapiens_hsa047101.28904794
23Type II diabetes mellitus_Homo sapiens_hsa049301.28459854
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28192041
25Nitrogen metabolism_Homo sapiens_hsa009101.27273739
26GABAergic synapse_Homo sapiens_hsa047271.27133851
27Dorso-ventral axis formation_Homo sapiens_hsa043201.26151640
28Renin secretion_Homo sapiens_hsa049241.26038982
29Focal adhesion_Homo sapiens_hsa045101.23683231
30Gastric acid secretion_Homo sapiens_hsa049711.20854118
31Adherens junction_Homo sapiens_hsa045201.19766535
32Salivary secretion_Homo sapiens_hsa049701.19487845
33cAMP signaling pathway_Homo sapiens_hsa040241.19408206
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.18785641
35Long-term potentiation_Homo sapiens_hsa047201.17657315
36Calcium signaling pathway_Homo sapiens_hsa040201.16550457
37Cholinergic synapse_Homo sapiens_hsa047251.16304918
38Olfactory transduction_Homo sapiens_hsa047401.16062509
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15668826
40Ovarian steroidogenesis_Homo sapiens_hsa049131.14486339
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13859123
42Sulfur metabolism_Homo sapiens_hsa009201.13314130
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12898168
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12550201
45Long-term depression_Homo sapiens_hsa047301.11121863
46Oxytocin signaling pathway_Homo sapiens_hsa049211.10910973
47Melanogenesis_Homo sapiens_hsa049161.10360965
48Glycerolipid metabolism_Homo sapiens_hsa005611.10225427
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08679955
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.08628621
51Arachidonic acid metabolism_Homo sapiens_hsa005901.08082585
52GnRH signaling pathway_Homo sapiens_hsa049121.07384229
53Wnt signaling pathway_Homo sapiens_hsa043101.04983660
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04124216
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03943361
56Dopaminergic synapse_Homo sapiens_hsa047281.03034155
57Basal cell carcinoma_Homo sapiens_hsa052171.02701655
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02095685
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00892945
60Hedgehog signaling pathway_Homo sapiens_hsa043401.00623410
61Cardiac muscle contraction_Homo sapiens_hsa042600.99439030
62Sphingolipid metabolism_Homo sapiens_hsa006000.97308109
63Ras signaling pathway_Homo sapiens_hsa040140.95425310
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95106138
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95094356
66Proteoglycans in cancer_Homo sapiens_hsa052050.94792727
67Butanoate metabolism_Homo sapiens_hsa006500.93727164
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93058484
69ErbB signaling pathway_Homo sapiens_hsa040120.92201197
70MAPK signaling pathway_Homo sapiens_hsa040100.92159117
71Regulation of autophagy_Homo sapiens_hsa041400.92114162
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91412230
73Caffeine metabolism_Homo sapiens_hsa002320.91406617
74Tryptophan metabolism_Homo sapiens_hsa003800.90535037
75Chemical carcinogenesis_Homo sapiens_hsa052040.90233802
76Pancreatic secretion_Homo sapiens_hsa049720.88274838
77Rap1 signaling pathway_Homo sapiens_hsa040150.87896731
78Retinol metabolism_Homo sapiens_hsa008300.87761968
79Bile secretion_Homo sapiens_hsa049760.87218065
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86164174
81Protein digestion and absorption_Homo sapiens_hsa049740.85535356
82Hippo signaling pathway_Homo sapiens_hsa043900.85028186
83Tight junction_Homo sapiens_hsa045300.84792276
84Gap junction_Homo sapiens_hsa045400.84052640
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83618571
86Estrogen signaling pathway_Homo sapiens_hsa049150.83408924
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80623907
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.80505142
89Prostate cancer_Homo sapiens_hsa052150.80348148
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80265846
91TGF-beta signaling pathway_Homo sapiens_hsa043500.79301342
92Amoebiasis_Homo sapiens_hsa051460.78271305
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76829023
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75955078
95Renal cell carcinoma_Homo sapiens_hsa052110.75484511
96Histidine metabolism_Homo sapiens_hsa003400.74818421
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.74541863
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.74534337
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73166977
100MicroRNAs in cancer_Homo sapiens_hsa052060.72003573
101Choline metabolism in cancer_Homo sapiens_hsa052310.70969689
102Ether lipid metabolism_Homo sapiens_hsa005650.70739011
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69969275
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69064124
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.68429430
106Glioma_Homo sapiens_hsa052140.67447702
107Melanoma_Homo sapiens_hsa052180.67260368
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67050433
109Mineral absorption_Homo sapiens_hsa049780.65909655
110Pathways in cancer_Homo sapiens_hsa052000.65873409
111Insulin resistance_Homo sapiens_hsa049310.65622275
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65325315
113Notch signaling pathway_Homo sapiens_hsa043300.65304382
114Vibrio cholerae infection_Homo sapiens_hsa051100.64892025
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64134311
116Small cell lung cancer_Homo sapiens_hsa052220.63588478
117PPAR signaling pathway_Homo sapiens_hsa033200.63122606
118Inositol phosphate metabolism_Homo sapiens_hsa005620.61899496
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61468756
120Thyroid hormone synthesis_Homo sapiens_hsa049180.60477359
121Vitamin digestion and absorption_Homo sapiens_hsa049770.60457791
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58860505
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58141434
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.58104077
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57975553
126Platelet activation_Homo sapiens_hsa046110.57709035
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56987151
128TNF signaling pathway_Homo sapiens_hsa046680.56773079
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56670765
130Fat digestion and absorption_Homo sapiens_hsa049750.55758082
131Malaria_Homo sapiens_hsa051440.55558782
132Synaptic vesicle cycle_Homo sapiens_hsa047210.54914234
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48595189
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.41293246
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40124645
136Complement and coagulation cascades_Homo sapiens_hsa046100.37133482
137Glucagon signaling pathway_Homo sapiens_hsa049220.36961663

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