MASTL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.85615973
2protein localization to kinetochore (GO:0034501)5.81921904
3kinetochore organization (GO:0051383)5.33626743
4metaphase plate congression (GO:0051310)5.29505147
5mitotic chromosome condensation (GO:0007076)5.17689210
6mitotic sister chromatid segregation (GO:0000070)5.14854944
7protein localization to chromosome, centromeric region (GO:0071459)4.99749802
8nuclear pore complex assembly (GO:0051292)4.92405895
9sister chromatid segregation (GO:0000819)4.85193595
10nuclear pore organization (GO:0006999)4.84485309
11establishment of chromosome localization (GO:0051303)4.81615015
12CENP-A containing nucleosome assembly (GO:0034080)4.81578253
13attachment of spindle microtubules to kinetochore (GO:0008608)4.79387562
14chromatin remodeling at centromere (GO:0031055)4.78432252
15regulation of spindle organization (GO:0090224)4.66378063
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.64583883
17kinetochore assembly (GO:0051382)4.63458079
18meiotic chromosome segregation (GO:0045132)4.58706826
19establishment of integrated proviral latency (GO:0075713)4.46654134
20regulation of mitotic spindle organization (GO:0060236)4.39372347
21mitotic nuclear envelope disassembly (GO:0007077)4.38622785
22DNA replication checkpoint (GO:0000076)4.34845015
23DNA replication-independent nucleosome organization (GO:0034724)4.33496721
24DNA replication-independent nucleosome assembly (GO:0006336)4.33496721
25spindle checkpoint (GO:0031577)4.19183767
26positive regulation of chromosome segregation (GO:0051984)4.16109490
27DNA replication initiation (GO:0006270)4.15403350
28DNA ligation (GO:0006266)4.13227826
29protein K6-linked ubiquitination (GO:0085020)4.12905043
30histone exchange (GO:0043486)4.12751057
31membrane disassembly (GO:0030397)4.09438730
32nuclear envelope disassembly (GO:0051081)4.09438730
33DNA replication-dependent nucleosome organization (GO:0034723)4.06778214
34DNA replication-dependent nucleosome assembly (GO:0006335)4.06778214
35positive regulation of mitotic sister chromatid separation (GO:1901970)4.02369008
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.02369008
37positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.02369008
38DNA unwinding involved in DNA replication (GO:0006268)4.00575775
39chromosome segregation (GO:0007059)3.99635169
40regulation of chromosome segregation (GO:0051983)3.99214271
41regulation of mitotic metaphase/anaphase transition (GO:0030071)3.94752865
42DNA strand elongation involved in DNA replication (GO:0006271)3.93602527
43regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.93261714
44DNA topological change (GO:0006265)3.90237118
45pore complex assembly (GO:0046931)3.89174052
46negative regulation of chromosome segregation (GO:0051985)3.88863765
47protein localization to chromosome (GO:0034502)3.88041979
48spindle assembly checkpoint (GO:0071173)3.86663185
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.86224283
50negative regulation of sister chromatid segregation (GO:0033046)3.86224283
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.86224283
52negative regulation of mitotic sister chromatid segregation (GO:0033048)3.86224283
53negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.84545399
54mitotic spindle checkpoint (GO:0071174)3.81854726
55regulation of centriole replication (GO:0046599)3.80787411
56mitotic sister chromatid cohesion (GO:0007064)3.80601383
57regulation of centrosome cycle (GO:0046605)3.80465338
58mitotic recombination (GO:0006312)3.77943260
59regulation of mitotic sister chromatid separation (GO:0010965)3.74648178
60regulation of mitotic sister chromatid segregation (GO:0033047)3.74648178
61regulation of sister chromatid segregation (GO:0033045)3.74648178
62mitotic spindle assembly checkpoint (GO:0007094)3.74328161
63DNA strand elongation (GO:0022616)3.73930726
64telomere maintenance via recombination (GO:0000722)3.71518307
65double-strand break repair via nonhomologous end joining (GO:0006303)3.70896288
66non-recombinational repair (GO:0000726)3.70896288
67telomere maintenance via semi-conservative replication (GO:0032201)3.70617314
68establishment of viral latency (GO:0019043)3.67201412
69regulation of sister chromatid cohesion (GO:0007063)3.65446083
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.64870811
71regulation of DNA endoreduplication (GO:0032875)3.60524816
72regulation of double-strand break repair via homologous recombination (GO:0010569)3.60398522
73heterochromatin organization (GO:0070828)3.52315444
74chromatin assembly or disassembly (GO:0006333)3.52237578
75microtubule depolymerization (GO:0007019)3.44898493
76regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42230617
77IMP biosynthetic process (GO:0006188)3.39135416
78chromosome condensation (GO:0030261)3.31893842
79telomere maintenance via telomere lengthening (GO:0010833)3.29338729
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.26624661
81protein complex localization (GO:0031503)3.26021702
82DNA geometric change (GO:0032392)3.24320635
83DNA duplex unwinding (GO:0032508)3.23540690
84ATP-dependent chromatin remodeling (GO:0043044)3.19289142
85nuclear envelope organization (GO:0006998)3.18823556
86mismatch repair (GO:0006298)3.18416004
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.17733685
88telomere organization (GO:0032200)3.17667063
89cellular protein complex localization (GO:0034629)3.14626726
90negative regulation of DNA-dependent DNA replication (GO:2000104)3.13711194
91negative regulation of histone methylation (GO:0031061)3.10945141
92folic acid-containing compound biosynthetic process (GO:0009396)3.10815314
93regulation of histone H3-K9 methylation (GO:0051570)3.10575835
94regulation of nuclear cell cycle DNA replication (GO:0033262)3.09887511
95somatic hypermutation of immunoglobulin genes (GO:0016446)3.08147407
96somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08147407
97negative regulation of mitosis (GO:0045839)3.08115541
98DNA packaging (GO:0006323)3.06426942
99mitotic G2 DNA damage checkpoint (GO:0007095)3.06326021
100regulation of telomere maintenance via telomerase (GO:0032210)3.06298735
101regulation of helicase activity (GO:0051095)3.06283255
102IMP metabolic process (GO:0046040)3.06198176
103translesion synthesis (GO:0019985)3.06080763
104postreplication repair (GO:0006301)3.05893871
105G1/S transition of mitotic cell cycle (GO:0000082)3.05748940
106regulation of centrosome duplication (GO:0010824)3.05521241
107mitotic G2/M transition checkpoint (GO:0044818)3.04940311
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03943838
109regulation of mitotic spindle checkpoint (GO:1903504)3.03943838
110nucleobase biosynthetic process (GO:0046112)3.03156545
111ribosome assembly (GO:0042255)3.02809064
112* mitotic cell cycle (GO:0000278)3.02372786
113DNA conformation change (GO:0071103)3.02086666
114regulation of double-strand break repair (GO:2000779)3.00992471
115replication fork processing (GO:0031297)2.99536205
116purine nucleobase biosynthetic process (GO:0009113)2.94114384
117telomere maintenance (GO:0000723)2.89770538
118chromosome organization (GO:0051276)2.87894979

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.78106468
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.86495960
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.37379002
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.44489600
5AR_21909140_ChIP-Seq_LNCAP_Human3.01994320
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75092728
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74680139
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.66134951
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57541065
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.45531743
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43156846
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41388866
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32331317
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.27895896
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.24725348
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.24624918
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12568490
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07255124
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04857269
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03815500
21E2F7_22180533_ChIP-Seq_HELA_Human10.9450121
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99729051
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.98999597
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91928132
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.84564506
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81498743
27VDR_23849224_ChIP-Seq_CD4+_Human1.79274330
28XRN2_22483619_ChIP-Seq_HELA_Human1.76244561
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75910439
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73752078
31ELK1_19687146_ChIP-ChIP_HELA_Human1.73095427
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71575601
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.66165203
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65325671
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64070209
36FOXP3_21729870_ChIP-Seq_TREG_Human1.59736595
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58950797
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57355268
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54887220
40DCP1A_22483619_ChIP-Seq_HELA_Human1.51420264
41TTF2_22483619_ChIP-Seq_HELA_Human1.50783051
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49944568
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37440843
44GABP_19822575_ChIP-Seq_HepG2_Human1.35746733
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35316620
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33446712
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30783678
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30369255
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29839766
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27125787
51* KDM5A_27292631_Chip-Seq_BREAST_Human1.26559170
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23125065
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20248553
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19534216
55* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19413554
56CIITA_25753668_ChIP-Seq_RAJI_Human1.18923296
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16011758
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15895933
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14349190
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12856425
61SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11961919
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07904802
63* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06910582
64MYC_18940864_ChIP-ChIP_HL60_Human1.05667451
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.05562088
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03770385
67* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03749678
68TFEB_21752829_ChIP-Seq_HELA_Human1.00661035
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00136929
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00109482
71NANOG_21062744_ChIP-ChIP_HESCs_Human0.98520355
72STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96386178
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96339265
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94611641
75* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94340912
76TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93855567
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93242144
78* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89289971
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88977039
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88977039
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88977039
82TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88471100
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87581103
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86598400
85SRF_21415370_ChIP-Seq_HL-1_Mouse0.85917122
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85645210
87ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83852041
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83311325
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83165199
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81764203
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81123535
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80967470
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80751784
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80484724
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.80232019
96NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80062393
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80017129
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79354504
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78236400
100MYC_22102868_ChIP-Seq_BL_Human0.78184311
101* CHD1_26751641_Chip-Seq_LNCaP_Human0.77164406
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75807540
103NANOG_16153702_ChIP-ChIP_HESCs_Human0.75578611
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75203841
105EWS_26573619_Chip-Seq_HEK293_Human0.74063177
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73978699
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.72867837
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72817741
109IRF1_19129219_ChIP-ChIP_H3396_Human0.72393475
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71057206
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.70597341
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70533413
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.70516711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.10378064
2MP0010094_abnormal_chromosome_stability4.99829978
3MP0003111_abnormal_nucleus_morphology4.60550782
4MP0003077_abnormal_cell_cycle4.16881556
5MP0004957_abnormal_blastocyst_morpholog4.00335890
6MP0008057_abnormal_DNA_replication3.61763401
7MP0008058_abnormal_DNA_repair3.10315655
8MP0008007_abnormal_cellular_replicative2.87612578
9MP0008877_abnormal_DNA_methylation2.86753176
10MP0008932_abnormal_embryonic_tissue2.69572732
11MP0003718_maternal_effect2.54392950
12MP0003123_paternal_imprinting2.43341241
13MP0010307_abnormal_tumor_latency2.39864425
14MP0000350_abnormal_cell_proliferation2.22477631
15MP0001730_embryonic_growth_arrest2.20762045
16MP0010352_gastrointestinal_tract_polyps2.15379175
17MP0003121_genomic_imprinting1.95928582
18MP0005380_embryogenesis_phenotype1.85210250
19MP0001672_abnormal_embryogenesis/_devel1.85210250
20MP0001697_abnormal_embryo_size1.78199613
21MP0003786_premature_aging1.74124646
22MP0002085_abnormal_embryonic_tissue1.68641816
23MP0002396_abnormal_hematopoietic_system1.63641726
24MP0003984_embryonic_growth_retardation1.59183780
25MP0002084_abnormal_developmental_patter1.57238030
26MP0002210_abnormal_sex_determination1.55502426
27MP0002088_abnormal_embryonic_growth/wei1.55300423
28MP0003890_abnormal_embryonic-extraembry1.51535803
29MP0005076_abnormal_cell_differentiation1.50552351
30MP0002877_abnormal_melanocyte_morpholog1.46251766
31MP0002086_abnormal_extraembryonic_tissu1.46198129
32MP0003705_abnormal_hypodermis_morpholog1.44688594
33MP0002080_prenatal_lethality1.40426362
34MP0001119_abnormal_female_reproductive1.39331029
35MP0000569_abnormal_digit_pigmentation1.39177035
36MP0003787_abnormal_imprinting1.37966839
37MP0000490_abnormal_crypts_of1.36364737
38MP0002009_preneoplasia1.35426706
39MP0003937_abnormal_limbs/digits/tail_de1.33694109
40MP0010030_abnormal_orbit_morphology1.32419102
41MP0003806_abnormal_nucleotide_metabolis1.31784974
42MP0004197_abnormal_fetal_growth/weight/1.31711296
43MP0001929_abnormal_gametogenesis1.31236971
44MP0003941_abnormal_skin_development1.29017078
45MP0001293_anophthalmia1.27370920
46MP0004808_abnormal_hematopoietic_stem1.26998334
47MP0000313_abnormal_cell_death1.25791857
48MP0000653_abnormal_sex_gland1.24956272
49MP0003315_abnormal_perineum_morphology1.24790944
50MP0002019_abnormal_tumor_incidence1.24071667
51MP0001145_abnormal_male_reproductive1.23579103
52MP0001346_abnormal_lacrimal_gland1.20220964
53MP0002102_abnormal_ear_morphology1.19818186
54MP0003221_abnormal_cardiomyocyte_apopto1.16161425
55MP0006292_abnormal_olfactory_placode1.09192672
56MP0000358_abnormal_cell_content/1.04530813
57MP0009053_abnormal_anal_canal1.03830747
58MP0004185_abnormal_adipocyte_glucose1.03818349
59MP0009697_abnormal_copulation0.99609023
60MP0006035_abnormal_mitochondrial_morpho0.99510078
61MP0003567_abnormal_fetal_cardiomyocyte0.99019402
62MP0005395_other_phenotype0.97999463
63MP0001853_heart_inflammation0.95514075
64MP0003699_abnormal_female_reproductive0.94329064
65MP0001915_intracranial_hemorrhage0.93470471
66MP0005389_reproductive_system_phenotype0.89888510
67MP0002111_abnormal_tail_morphology0.88732164
68MP0005621_abnormal_cell_physiology0.87204243
69MP0000432_abnormal_head_morphology0.86104087
70MP0003755_abnormal_palate_morphology0.85577233
71MP0005023_abnormal_wound_healing0.83986586
72MP0001727_abnormal_embryo_implantation0.83522073
73MP0010234_abnormal_vibrissa_follicle0.82924073
74MP0004264_abnormal_extraembryonic_tissu0.81723572
75MP0002254_reproductive_system_inflammat0.81648295
76MP0003566_abnormal_cell_adhesion0.81485681
77MP0005384_cellular_phenotype0.81356025
78MP0001286_abnormal_eye_development0.80928113
79MP0001545_abnormal_hematopoietic_system0.78921103
80MP0005397_hematopoietic_system_phenotyp0.78921103
81MP0005408_hypopigmentation0.78078669
82MP0003119_abnormal_digestive_system0.77910872
83MP0002160_abnormal_reproductive_system0.76823630
84MP0002163_abnormal_gland_morphology0.76466394
85MP0003950_abnormal_plasma_membrane0.75231597
86MP0005501_abnormal_skin_physiology0.74761568
87MP0001919_abnormal_reproductive_system0.74580253
88MP0005367_renal/urinary_system_phenotyp0.74282656
89MP0000516_abnormal_urinary_system0.74282656
90MP0009703_decreased_birth_body0.73613546
91MP0004233_abnormal_muscle_weight0.73323980
92MP0002006_tumorigenesis0.72601483
93MP0002092_abnormal_eye_morphology0.72231082
94MP0002653_abnormal_ependyma_morphology0.72126975
95MP0000537_abnormal_urethra_morphology0.71586353
96MP0001216_abnormal_epidermal_layer0.70421897
97MP0003935_abnormal_craniofacial_develop0.70305800
98MP0002796_impaired_skin_barrier0.68793804
99MP0000703_abnormal_thymus_morphology0.68338103
100MP0000733_abnormal_muscle_development0.66785484
101MP0003943_abnormal_hepatobiliary_system0.65965821
102MP0002161_abnormal_fertility/fecundity0.65714525
103MP0000428_abnormal_craniofacial_morphol0.65367382
104MP0002697_abnormal_eye_size0.63326380
105MP0000627_abnormal_mammary_gland0.61572787
106MP0009672_abnormal_birth_weight0.60679951
107MP0000858_altered_metastatic_potential0.59735648
108MP0003656_abnormal_erythrocyte_physiolo0.59503929
109MP0006054_spinal_hemorrhage0.57914927
110MP0002938_white_spotting0.57482288
111MP0002398_abnormal_bone_marrow0.57455384
112MP0003453_abnormal_keratinocyte_physiol0.57400571
113MP0003861_abnormal_nervous_system0.57248071
114MP0003448_altered_tumor_morphology0.57079489
115MP0002075_abnormal_coat/hair_pigmentati0.56304574
116MP0009333_abnormal_splenocyte_physiolog0.56246340
117MP0002925_abnormal_cardiovascular_devel0.56154134
118MP0003936_abnormal_reproductive_system0.55985065
119MP0000566_synostosis0.55405454
120MP0000647_abnormal_sebaceous_gland0.55401067
121MP0003698_abnormal_male_reproductive0.55315242
122MP0001243_abnormal_dermal_layer0.54789341
123MP0000383_abnormal_hair_follicle0.54556197
124MP0005647_abnormal_sex_gland0.54390213
125MP0001881_abnormal_mammary_gland0.54059944
126MP0002722_abnormal_immune_system0.53573651
127MP0005623_abnormal_meninges_morphology0.53429836
128MP0003763_abnormal_thymus_physiology0.52160257
129MP0002233_abnormal_nose_morphology0.52079613
130MP0001191_abnormal_skin_condition0.51862554
131MP0005266_abnormal_metabolism0.51323321

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.95104411
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.68450129
3Birth length less than 3rd percentile (HP:0003561)4.87075442
4Abnormality of chromosome stability (HP:0003220)4.17838849
5Breast hypoplasia (HP:0003187)3.88368774
6Abnormality of the preputium (HP:0100587)3.77029181
7Meckel diverticulum (HP:0002245)3.76264431
8Abnormality of the labia minora (HP:0012880)3.70106819
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.62995793
10Patellar aplasia (HP:0006443)3.53218618
11Abnormality of the ileum (HP:0001549)3.51549592
12Impulsivity (HP:0100710)3.41018971
13Small intestinal stenosis (HP:0012848)3.33328945
14Duodenal stenosis (HP:0100867)3.33328945
15Aplasia/Hypoplasia of the patella (HP:0006498)3.24090433
16Ectopic kidney (HP:0000086)3.18378575
17Absent radius (HP:0003974)3.12201032
18Medulloblastoma (HP:0002885)3.09491016
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06301516
20Supernumerary spleens (HP:0009799)3.02609167
21Volvulus (HP:0002580)2.92088510
22Absent forearm bone (HP:0003953)2.91640616
23Aplasia involving forearm bones (HP:0009822)2.91640616
24Selective tooth agenesis (HP:0001592)2.90152796
25Myelodysplasia (HP:0002863)2.86250700
26Colon cancer (HP:0003003)2.84579576
27Rhabdomyosarcoma (HP:0002859)2.80874287
28Sloping forehead (HP:0000340)2.80034953
29Ependymoma (HP:0002888)2.73179621
30Agnosia (HP:0010524)2.71828373
31Abnormality of the duodenum (HP:0002246)2.68122492
32Abnormality of the carotid arteries (HP:0005344)2.58052859
33Abnormal lung lobation (HP:0002101)2.57996984
34Facial hemangioma (HP:0000329)2.51812721
35Nephroblastoma (Wilms tumor) (HP:0002667)2.47000786
36Bone marrow hypocellularity (HP:0005528)2.46305297
37Carpal bone hypoplasia (HP:0001498)2.44395388
38Increased nuchal translucency (HP:0010880)2.43478548
39Multiple enchondromatosis (HP:0005701)2.41253075
40Embryonal renal neoplasm (HP:0011794)2.40094071
41Clubbing of toes (HP:0100760)2.39900867
42Short thumb (HP:0009778)2.39607924
43Oral leukoplakia (HP:0002745)2.37650990
44Prostate neoplasm (HP:0100787)2.35802565
45Aplasia/Hypoplasia of the sternum (HP:0006714)2.34622335
46Deviation of the thumb (HP:0009603)2.31758751
47Choanal atresia (HP:0000453)2.30922490
48Absent thumb (HP:0009777)2.30771857
49Duplicated collecting system (HP:0000081)2.28413238
50Microvesicular hepatic steatosis (HP:0001414)2.27475732
51Cortical dysplasia (HP:0002539)2.26634598
52Cafe-au-lait spot (HP:0000957)2.23944707
53Proximal placement of thumb (HP:0009623)2.22202693
54Reticulocytopenia (HP:0001896)2.20516934
55Embryonal neoplasm (HP:0002898)2.17632927
56Abnormality of abdominal situs (HP:0011620)2.15788014
57Abdominal situs inversus (HP:0003363)2.15788014
58Tracheoesophageal fistula (HP:0002575)2.14681384
59Triphalangeal thumb (HP:0001199)2.13464946
60Abnormality of the renal collecting system (HP:0004742)2.12943453
61Spastic diplegia (HP:0001264)2.12381222
62Neoplasm of the pancreas (HP:0002894)2.11328609
63Rough bone trabeculation (HP:0100670)2.10487162
64Abnormal number of incisors (HP:0011064)2.10270153
65Overlapping toe (HP:0001845)2.09180283
66IgA deficiency (HP:0002720)2.09147382
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07758815
68Short 4th metacarpal (HP:0010044)2.07758815
69Premature graying of hair (HP:0002216)2.07613083
70Abnormality of the anterior horn cell (HP:0006802)2.07068503
71Degeneration of anterior horn cells (HP:0002398)2.07068503
72Horseshoe kidney (HP:0000085)2.06124896
73Astrocytoma (HP:0009592)2.06103033
74Abnormality of the astrocytes (HP:0100707)2.06103033
75Atresia of the external auditory canal (HP:0000413)2.03976262
76Papillary thyroid carcinoma (HP:0002895)2.03148621
77Glioma (HP:0009733)2.02405295
78Leiomyosarcoma (HP:0100243)2.00148720
79Uterine leiomyosarcoma (HP:0002891)2.00148720
80Progressive external ophthalmoplegia (HP:0000590)1.99536655
81Abnormality of chromosome segregation (HP:0002916)1.98895478
82Neoplasm of the oral cavity (HP:0100649)1.98426541
83Prominent nose (HP:0000448)1.98094516
84Short middle phalanx of the 5th finger (HP:0004220)1.96871933
85Neoplasm of striated muscle (HP:0009728)1.96079974
86High pitched voice (HP:0001620)1.95607743
87Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93993274
88Microglossia (HP:0000171)1.93088860
89Neoplasm of the colon (HP:0100273)1.92305944
90Shawl scrotum (HP:0000049)1.91806585
9111 pairs of ribs (HP:0000878)1.90216975
92Oligodactyly (HP:0012165)1.90046649
93Wrist flexion contracture (HP:0001239)1.89849090
94Biliary tract neoplasm (HP:0100574)1.89084752
95Abnormality of the pons (HP:0007361)1.88164655
96Premature ovarian failure (HP:0008209)1.86556517
97Breast aplasia (HP:0100783)1.85475748
98Acute myeloid leukemia (HP:0004808)1.85274362
99Capillary hemangiomas (HP:0005306)1.85189172
100Abnormality of cochlea (HP:0000375)1.85011403
101Deep philtrum (HP:0002002)1.83875596
102Abnormality of methionine metabolism (HP:0010901)1.83830696
103Malignant gastrointestinal tract tumors (HP:0006749)1.82907691
104Gastrointestinal carcinoma (HP:0002672)1.82907691
105Abnormality of the fetal cardiovascular system (HP:0010948)1.81850195
106Abnormal umbilical cord blood vessels (HP:0011403)1.81850195
107Single umbilical artery (HP:0001195)1.81850195
108Oligodactyly (hands) (HP:0001180)1.81685433
109Arteriovenous malformation (HP:0100026)1.80989745
110Pancytopenia (HP:0001876)1.80616579
111Duplication of thumb phalanx (HP:0009942)1.80156062
112Aplasia/Hypoplasia of the breasts (HP:0010311)1.79367079
113Abnormal spermatogenesis (HP:0008669)1.78682930
114Abnormality of DNA repair (HP:0003254)1.78269941
115Sandal gap (HP:0001852)1.78216509
116Hypoplasia of the pons (HP:0012110)1.76743217
117Abnormality of glycolysis (HP:0004366)1.76740348
118Aplasia/hypoplasia of the humerus (HP:0006507)1.76456665
119IgM deficiency (HP:0002850)1.76428768
120Abnormality of the umbilical cord (HP:0010881)1.75655614
121Ureteral duplication (HP:0000073)1.75283687
122Uterine neoplasm (HP:0010784)1.75120456
123Blepharitis (HP:0000498)1.74284097
124High anterior hairline (HP:0009890)1.72794118
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71787385
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71772306
127Increased serum pyruvate (HP:0003542)1.71188505
128Poikiloderma (HP:0001029)1.70839525
129Squamous cell carcinoma (HP:0002860)1.70271272
130Combined immunodeficiency (HP:0005387)1.70055862
131Shoulder girdle muscle weakness (HP:0003547)1.70010336
132Abnormality of the proximal phalanges of the hand (HP:0009834)1.69691759
133Abnormal trabecular bone morphology (HP:0100671)1.69173301
134Hypoplastic pelvis (HP:0008839)1.68861060
135Breast carcinoma (HP:0003002)1.68416364
136Cleft eyelid (HP:0000625)1.66600418
137Ovarian neoplasm (HP:0100615)1.64161472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.89508508
2BUB13.90280239
3WEE13.78474857
4TTK3.75935704
5PLK43.18128885
6NEK23.10755411
7BRSK23.06969992
8PLK12.53675390
9CDK122.41092594
10SRPK12.38302078
11ACVR1B2.22164533
12EIF2AK12.21027790
13PLK32.10307308
14NEK12.08717693
15AURKB2.08245421
16CHEK22.07225467
17LATS11.92488836
18ZAK1.91614851
19ATR1.82838796
20BRSK11.81133010
21STK101.79897997
22STK38L1.71568567
23MST41.68014739
24STK31.57241141
25MAP3K81.50772490
26CDK71.50023847
27CHEK11.46772694
28MELK1.44768490
29MKNK11.41895743
30VRK21.41238437
31STK41.40931550
32EPHA21.37896932
33CDK41.36793703
34VRK11.36304011
35TAF11.33917346
36BRAF1.32551131
37IRAK31.31959292
38AURKA1.30466401
39RPS6KA41.28787756
40TSSK61.27722474
41ATM1.25869938
42RPS6KB21.24572517
43LATS21.21984362
44PBK1.17152591
45MKNK21.15731174
46MAP3K101.14289298
47TRIM281.13584303
48TLK11.10639319
49EEF2K1.10477974
50CCNB11.04500514
51CDK61.02156173
52BRD40.99745786
53PASK0.97716940
54EIF2AK30.96293594
55CDK20.95662238
56NUAK10.92882698
57ERBB40.90808033
58MAP3K60.89946427
59DYRK30.86393897
60EIF2AK20.84564057
61CDK10.84266142
62SMG10.82952772
63BCR0.82763065
64CDK80.80022466
65MAP3K140.78159039
66NEK90.71855990
67PIM10.71452987
68TESK20.69280748
69CDK90.65906701
70TGFBR10.64201861
71TRPM70.62425061
72SCYL20.58427188
73MOS0.48999945
74MET0.48157654
75CSNK2A10.47655945
76BMPR1B0.47610030
77PAK10.46835167
78PAK40.45622768
79NME20.44086493
80CSNK2A20.43848903
81MARK30.43611009
82RPS6KA50.43460583
83AKT30.42807951
84MAPKAPK30.42530447
85ERBB30.41278316
86PLK20.40888561
87PRKDC0.39699152
88KSR10.39076692
89CDK180.38834923
90PRKCI0.38660272
91PDK20.38289532
92CSNK1D0.37754540
93MAP3K120.37138081
94CDK11A0.36712372
95MTOR0.36593462
96CDK150.36400096
97MAPK140.35895796
98YES10.33778050
99CDK140.33747571
100CHUK0.32842972
101TAOK20.32307572
102ALK0.30750361
103CSNK1E0.30501518
104AKT10.30314064
105STK160.29913738
106CSNK1G10.29188727
107TAOK30.28986936
108DYRK20.26409880
109MAPK10.26297079
110IRAK20.25714690
111SIK30.25708144
112GSK3B0.25527656
113CLK10.24566833
114CDK30.24329592
115FGFR10.24109009
116RAF10.23356116
117MAP3K90.21572218
118MAP3K50.21254659
119STK240.16690694
120PNCK0.15918188
121LRRK20.15808212
122FRK0.15298445
123AKT20.14179134

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58922431
2Mismatch repair_Homo sapiens_hsa034304.33705464
3Cell cycle_Homo sapiens_hsa041103.71515665
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.60789437
5Homologous recombination_Homo sapiens_hsa034403.58262786
6RNA transport_Homo sapiens_hsa030133.20390333
7Fanconi anemia pathway_Homo sapiens_hsa034603.14157844
8Base excision repair_Homo sapiens_hsa034102.96569372
9Nucleotide excision repair_Homo sapiens_hsa034202.86011205
10Spliceosome_Homo sapiens_hsa030402.79861674
11RNA polymerase_Homo sapiens_hsa030202.59415078
12Non-homologous end-joining_Homo sapiens_hsa034502.55615730
13One carbon pool by folate_Homo sapiens_hsa006702.53786507
14Basal transcription factors_Homo sapiens_hsa030222.44459862
15RNA degradation_Homo sapiens_hsa030182.30707246
16p53 signaling pathway_Homo sapiens_hsa041152.27032428
17Proteasome_Homo sapiens_hsa030502.01103027
18mRNA surveillance pathway_Homo sapiens_hsa030151.96961413
19Pyrimidine metabolism_Homo sapiens_hsa002401.96764656
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96604602
21Systemic lupus erythematosus_Homo sapiens_hsa053221.60897311
22Oocyte meiosis_Homo sapiens_hsa041141.46281470
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.41800824
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40048602
25Ribosome_Homo sapiens_hsa030101.28685503
26Viral carcinogenesis_Homo sapiens_hsa052031.24454151
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22928452
28MicroRNAs in cancer_Homo sapiens_hsa052061.21206352
29Steroid biosynthesis_Homo sapiens_hsa001001.17843367
30Epstein-Barr virus infection_Homo sapiens_hsa051691.17184192
31Herpes simplex infection_Homo sapiens_hsa051681.10217832
32Protein export_Homo sapiens_hsa030601.10185429
33Purine metabolism_Homo sapiens_hsa002301.06956927
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02089656
35Vitamin B6 metabolism_Homo sapiens_hsa007500.99564910
36TGF-beta signaling pathway_Homo sapiens_hsa043500.98009850
37Small cell lung cancer_Homo sapiens_hsa052220.93127133
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91019177
39HTLV-I infection_Homo sapiens_hsa051660.90930405
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78186397
41Hippo signaling pathway_Homo sapiens_hsa043900.75809004
42Pyruvate metabolism_Homo sapiens_hsa006200.74598252
43Adherens junction_Homo sapiens_hsa045200.73940015
44Thyroid cancer_Homo sapiens_hsa052160.73095523
45Carbon metabolism_Homo sapiens_hsa012000.72095386
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72083378
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70711148
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68571319
49Antigen processing and presentation_Homo sapiens_hsa046120.66901427
50Colorectal cancer_Homo sapiens_hsa052100.66806606
51Fatty acid elongation_Homo sapiens_hsa000620.62479404
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59519809
53Basal cell carcinoma_Homo sapiens_hsa052170.55954919
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55452381
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54820378
56Alcoholism_Homo sapiens_hsa050340.54734485
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54724890
58Selenocompound metabolism_Homo sapiens_hsa004500.53753995
59Apoptosis_Homo sapiens_hsa042100.53591679
60Hepatitis B_Homo sapiens_hsa051610.52093405
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.51771373
62Pancreatic cancer_Homo sapiens_hsa052120.50189131
63N-Glycan biosynthesis_Homo sapiens_hsa005100.50041416
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.49426725
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47586116
66FoxO signaling pathway_Homo sapiens_hsa040680.47073610
67Prostate cancer_Homo sapiens_hsa052150.45785732
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45318130
69Shigellosis_Homo sapiens_hsa051310.44682415
70Influenza A_Homo sapiens_hsa051640.44108725
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.43720080
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43686030
73Measles_Homo sapiens_hsa051620.43189696
74Legionellosis_Homo sapiens_hsa051340.43185455
75Pathways in cancer_Homo sapiens_hsa052000.41683614
76Bladder cancer_Homo sapiens_hsa052190.40248173
77Chronic myeloid leukemia_Homo sapiens_hsa052200.40203478
78Notch signaling pathway_Homo sapiens_hsa043300.39367996
79Hedgehog signaling pathway_Homo sapiens_hsa043400.38648221
80Folate biosynthesis_Homo sapiens_hsa007900.36199554
81Lysine degradation_Homo sapiens_hsa003100.35024799
82Pentose phosphate pathway_Homo sapiens_hsa000300.33295623
83Melanoma_Homo sapiens_hsa052180.33237640
84mTOR signaling pathway_Homo sapiens_hsa041500.33029252
85Biosynthesis of amino acids_Homo sapiens_hsa012300.31441820
86Viral myocarditis_Homo sapiens_hsa054160.31266605
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31187793
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30454266
89Ovarian steroidogenesis_Homo sapiens_hsa049130.30355582
90Galactose metabolism_Homo sapiens_hsa000520.28071951
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27398934
92Hematopoietic cell lineage_Homo sapiens_hsa046400.25855444
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25583861
94HIF-1 signaling pathway_Homo sapiens_hsa040660.25104806
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.25008534
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22636435
97Tight junction_Homo sapiens_hsa045300.22450138
98Proteoglycans in cancer_Homo sapiens_hsa052050.22337677
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.22312553
100Endometrial cancer_Homo sapiens_hsa052130.21709898
101Wnt signaling pathway_Homo sapiens_hsa043100.20860045
102Glutathione metabolism_Homo sapiens_hsa004800.20228865
103TNF signaling pathway_Homo sapiens_hsa046680.19615637
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19524396
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19030668
106Propanoate metabolism_Homo sapiens_hsa006400.19009316
107Huntingtons disease_Homo sapiens_hsa050160.18709429
108Autoimmune thyroid disease_Homo sapiens_hsa053200.18612580
109Linoleic acid metabolism_Homo sapiens_hsa005910.17927076
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17513510
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16576338
112Non-small cell lung cancer_Homo sapiens_hsa052230.15008125
113Hepatitis C_Homo sapiens_hsa051600.15001820
114Toxoplasmosis_Homo sapiens_hsa051450.14141983
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.12985003
116Arachidonic acid metabolism_Homo sapiens_hsa005900.12805866
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11106585
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11100431
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.10976231
120Metabolic pathways_Homo sapiens_hsa011000.10854726
121ECM-receptor interaction_Homo sapiens_hsa045120.10816022
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10612242
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10233432
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.09679194
125Circadian rhythm_Homo sapiens_hsa047100.09567383

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