MAT1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.43732291
2omega-hydroxylase P450 pathway (GO:0097267)8.40352105
3epoxygenase P450 pathway (GO:0019373)8.40288600
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.78656729
5L-phenylalanine catabolic process (GO:0006559)7.78656729
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.43874078
7L-phenylalanine metabolic process (GO:0006558)7.43874078
8aromatic amino acid family catabolic process (GO:0009074)6.88669028
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.43586119
10indole-containing compound catabolic process (GO:0042436)6.07153598
11indolalkylamine catabolic process (GO:0046218)6.07153598
12tryptophan catabolic process (GO:0006569)6.07153598
13drug metabolic process (GO:0017144)6.00146435
14urea metabolic process (GO:0019627)5.99227968
15urea cycle (GO:0000050)5.99227968
16kynurenine metabolic process (GO:0070189)5.96286926
17bile acid biosynthetic process (GO:0006699)5.84729688
18tryptophan metabolic process (GO:0006568)5.73494637
19glyoxylate metabolic process (GO:0046487)5.73084511
20oxidative demethylation (GO:0070989)5.65919823
21high-density lipoprotein particle remodeling (GO:0034375)5.63053213
22alpha-linolenic acid metabolic process (GO:0036109)5.62274568
23negative regulation of fibrinolysis (GO:0051918)5.58881679
24nitrogen cycle metabolic process (GO:0071941)5.50998134
25regulation of plasminogen activation (GO:0010755)5.47759084
26cysteine metabolic process (GO:0006534)5.46518409
27sulfur amino acid catabolic process (GO:0000098)5.44780893
28ethanol metabolic process (GO:0006067)5.41109463
29regulation of fibrinolysis (GO:0051917)5.34701978
30peptidyl-glutamic acid carboxylation (GO:0017187)5.29636035
31protein carboxylation (GO:0018214)5.29636035
32serine family amino acid catabolic process (GO:0009071)5.25277510
33regulation of protein activation cascade (GO:2000257)5.08194888
34complement activation, alternative pathway (GO:0006957)5.06910955
35bile acid metabolic process (GO:0008206)5.04327781
36regulation of cholesterol esterification (GO:0010872)5.01254033
37aromatic amino acid family metabolic process (GO:0009072)5.00656615
38tyrosine metabolic process (GO:0006570)5.00583815
39homocysteine metabolic process (GO:0050667)5.00280744
40reverse cholesterol transport (GO:0043691)4.91560363
41regulation of triglyceride catabolic process (GO:0010896)4.87048071
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85235616
43plasma lipoprotein particle remodeling (GO:0034369)4.84461342
44protein-lipid complex remodeling (GO:0034368)4.84461342
45macromolecular complex remodeling (GO:0034367)4.84461342
46phenylpropanoid metabolic process (GO:0009698)4.84104114
47amino-acid betaine metabolic process (GO:0006577)4.81809473
48negative regulation of hemostasis (GO:1900047)4.79280868
49negative regulation of blood coagulation (GO:0030195)4.79280868
50regulation of humoral immune response (GO:0002920)4.77167457
51alpha-amino acid catabolic process (GO:1901606)4.74179756
52regulation of complement activation (GO:0030449)4.69968545
53phospholipid efflux (GO:0033700)4.65305526
54lysine metabolic process (GO:0006553)4.61607235
55lysine catabolic process (GO:0006554)4.61607235
56opsonization (GO:0008228)4.60856201
57acylglycerol homeostasis (GO:0055090)4.59765273
58triglyceride homeostasis (GO:0070328)4.59765273
59negative regulation of sterol transport (GO:0032372)4.59007342
60negative regulation of cholesterol transport (GO:0032375)4.59007342
61negative regulation of protein activation cascade (GO:2000258)4.58012326
62cellular ketone body metabolic process (GO:0046950)4.52625618
63positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.46475305
64glycine metabolic process (GO:0006544)4.42566714
65imidazole-containing compound metabolic process (GO:0052803)4.41452945
66plasma lipoprotein particle clearance (GO:0034381)4.40703150
67intestinal cholesterol absorption (GO:0030299)4.39907990
68negative regulation of coagulation (GO:0050819)4.36009168
69cellular amino acid catabolic process (GO:0009063)4.35976870
70coenzyme catabolic process (GO:0009109)4.31699906
71indolalkylamine metabolic process (GO:0006586)4.31595934
72bile acid and bile salt transport (GO:0015721)4.30878749
73glutamate metabolic process (GO:0006536)4.30708236
74negative regulation of wound healing (GO:0061045)4.30288504
75disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.29594332
76killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.29594332
77cytolysis (GO:0019835)4.29203106
78cholesterol efflux (GO:0033344)4.25529505
79serine family amino acid metabolic process (GO:0009069)4.21996758
80positive regulation of hemostasis (GO:1900048)4.21984087
81positive regulation of blood coagulation (GO:0030194)4.21984087
82arginine metabolic process (GO:0006525)4.21880524
83amine catabolic process (GO:0009310)4.20839956
84cellular biogenic amine catabolic process (GO:0042402)4.20839956
85cellular glucuronidation (GO:0052695)4.15737734
86cellular modified amino acid catabolic process (GO:0042219)4.12050066
87serine family amino acid biosynthetic process (GO:0009070)4.08727034
88low-density lipoprotein particle remodeling (GO:0034374)4.08054480
89benzene-containing compound metabolic process (GO:0042537)4.07949853
90dicarboxylic acid biosynthetic process (GO:0043650)4.06278374
91plasma lipoprotein particle assembly (GO:0034377)4.04663547
92aldehyde catabolic process (GO:0046185)4.03064032
93alkaloid metabolic process (GO:0009820)4.02242283
94fibrinolysis (GO:0042730)3.96075135
95ethanol oxidation (GO:0006069)3.94170857
96drug catabolic process (GO:0042737)3.92365118
97ketone body metabolic process (GO:1902224)3.91768644
98positive regulation of coagulation (GO:0050820)3.88330877
99negative regulation of lipase activity (GO:0060192)3.83932792
100positive regulation of lipoprotein lipase activity (GO:0051006)3.81247003
101positive regulation of triglyceride lipase activity (GO:0061365)3.81247003
102organic acid catabolic process (GO:0016054)3.80815822
103carboxylic acid catabolic process (GO:0046395)3.80815822
104response to mercury ion (GO:0046689)3.80703701
105blood coagulation, intrinsic pathway (GO:0007597)3.79633910
106positive regulation of lipid catabolic process (GO:0050996)3.79161084
107regulation of apoptotic cell clearance (GO:2000425)3.77269951
108cofactor catabolic process (GO:0051187)3.75548757
109phospholipid homeostasis (GO:0055091)3.73969488
110cholesterol homeostasis (GO:0042632)3.73360361
111very-low-density lipoprotein particle assembly (GO:0034379)3.73289875
112regulation of bile acid biosynthetic process (GO:0070857)3.72696454
113uronic acid metabolic process (GO:0006063)3.68385137
114glucuronate metabolic process (GO:0019585)3.68385137
115sterol homeostasis (GO:0055092)3.67119930
116plasma lipoprotein particle organization (GO:0071827)3.66698160
117short-chain fatty acid metabolic process (GO:0046459)3.64541654
118regulation of cholesterol homeostasis (GO:2000188)3.62966079
119protein-lipid complex assembly (GO:0065005)3.62778907
120negative regulation of complement activation (GO:0045916)3.61512289
121acetyl-CoA metabolic process (GO:0006084)3.61124042
122protein activation cascade (GO:0072376)3.58823299
123acute inflammatory response (GO:0002526)3.58614704
124hormone catabolic process (GO:0042447)3.55608802
125complement activation, classical pathway (GO:0006958)3.55128673
126complement activation (GO:0006956)3.54870404
127acute-phase response (GO:0006953)3.54186098
128flavonoid metabolic process (GO:0009812)3.54117130
129NAD biosynthetic process (GO:0009435)3.52029698
130* S-adenosylmethionine metabolic process (GO:0046500)3.50334195
131fat-soluble vitamin biosynthetic process (GO:0042362)3.48962873
132heme transport (GO:0015886)3.46962750
133positive regulation of fatty acid biosynthetic process (GO:0045723)3.43400213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.46764152
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21535049
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.87753333
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.53926376
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28536962
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.12975319
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89817133
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99771007
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.93088054
10* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06172774
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00449727
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00047194
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0039152
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60536531
15CLOCK_20551151_ChIP-Seq_293T_Human1.56537278
16HTT_18923047_ChIP-ChIP_STHdh_Human1.52792334
17GATA1_22025678_ChIP-Seq_K562_Human1.45396666
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40781374
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31513083
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22829610
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18289331
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17783604
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.12604186
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09717877
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07637769
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00496892
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97614860
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94828172
29SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92860406
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91299313
31IRF8_22096565_ChIP-ChIP_GC-B_Human0.84832155
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84482886
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84168426
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83861722
35AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83796219
36GATA4_25053715_ChIP-Seq_YYC3_Human0.80896684
37RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80881655
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80363256
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79011581
40SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77060068
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75783716
42SOX2_21211035_ChIP-Seq_LN229_Human0.74818237
43SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74155177
44KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73690490
45RARA_24833708_ChIP-Seq_LIVER_Mouse0.72859228
46HNFA_21074721_ChIP-Seq_CACO-2_Human0.72777226
47CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.71879666
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70507227
49ZNF263_19887448_ChIP-Seq_K562_Human0.70329506
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69575279
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.69391626
52AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68113342
53NFE2_27457419_Chip-Seq_LIVER_Mouse0.68067541
54PHF8_20622853_ChIP-Seq_HELA_Human0.65779744
55TP53_18474530_ChIP-ChIP_U2OS_Human0.65732982
56ESR2_21235772_ChIP-Seq_MCF-7_Human0.65038704
57SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64812126
58RAC3_21632823_ChIP-Seq_H3396_Human0.64531160
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63168196
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62656719
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62405231
62NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62195169
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62195169
64RARB_24833708_ChIP-Seq_LIVER_Mouse0.61822716
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61355076
66RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60878863
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60701143
68TCF4_18268006_ChIP-ChIP_LS174T_Human0.59439009
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.58355677
70IRF1_19129219_ChIP-ChIP_H3396_Human0.57185563
71CEBPB_22108803_ChIP-Seq_LS180_Human0.57158351
72NFYA_21822215_ChIP-Seq_K562_Human0.56941315
73CBX2_22325352_ChIP-Seq_293T-Rex_Human0.55966766
74SMC4_20622854_ChIP-Seq_HELA_Human0.55701797
75LXR_22292898_ChIP-Seq_THP-1_Human0.55495326
76SOX2_20726797_ChIP-Seq_SW620_Human0.55153455
77ETV2_25802403_ChIP-Seq_MESCs_Mouse0.54396041
78GATA6_21074721_ChIP-Seq_CACO-2_Human0.54277503
79POU5F1_16518401_ChIP-PET_MESCs_Mouse0.54187651
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.53507076
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.53122976
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.52717166
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52600420
84FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52510108
85EGR1_19032775_ChIP-ChIP_M12_Human0.52463499
86MYC_19829295_ChIP-Seq_ESCs_Human0.52195370
87* FOXA1_25552417_ChIP-Seq_VCAP_Human0.52102404
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.52090438
89AR_20517297_ChIP-Seq_VCAP_Human0.52034732
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.51686955
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51162157
92MYC_19915707_ChIP-ChIP_AK7_Human0.49537666
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49038066
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.49035400
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.48576044
96ETV1_20927104_ChIP-Seq_GIST48_Human0.48462281
97P53_21459846_ChIP-Seq_SAOS-2_Human0.48433522
98CTCF_27219007_Chip-Seq_Bcells_Human0.48189905
99ESET_19884257_ChIP-Seq_ESCs_Mouse0.47864007
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.47791918
101* SPI1_20517297_ChIP-Seq_HL60_Human0.47787572
102* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47784551
103P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.47319983
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46379792
105PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45955062
106* CBP_21632823_ChIP-Seq_H3396_Human0.45635540
107STAT1_17558387_ChIP-Seq_HELA_Human0.45417578
108GATA1_19941826_ChIP-Seq_K562_Human0.44361492
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42888808
110TAF15_26573619_Chip-Seq_HEK293_Human0.42540695
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42396505
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.42249850
113TAF2_19829295_ChIP-Seq_ESCs_Human0.41969616
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.41574709
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.41415849
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41363871
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.40023314
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39753875
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.38884646
120GATA6_25053715_ChIP-Seq_YYC3_Human0.38820170
121MYC_27129775_Chip-Seq_CORNEA_Mouse0.38589077
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38124520
123* GATA2_19941826_ChIP-Seq_K562_Human0.38072779
124BCAT_22108803_ChIP-Seq_LS180_Human0.38040554
125LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36219557
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.35914077
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.34847079
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33661261
129SPI1_26923725_Chip-Seq_HPCs_Mouse0.33515065
130NCOR_22424771_ChIP-Seq_293T_Human0.33322194
131ERG_20517297_ChIP-Seq_VCAP_Human0.33150557
132CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.32968419
133FOXH1_21741376_ChIP-Seq_EPCs_Human0.32931764
134CDX2_22108803_ChIP-Seq_LS180_Human0.32830719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.20641316
2MP0005360_urolithiasis7.47424085
3MP0005085_abnormal_gallbladder_physiolo6.43181394
4MP0005365_abnormal_bile_salt6.24433390
5MP0008875_abnormal_xenobiotic_pharmacok5.17694645
6MP0003806_abnormal_nucleotide_metabolis4.19134940
7MP0003252_abnormal_bile_duct3.90021641
8MP0010329_abnormal_lipoprotein_level3.58889146
9MP0009840_abnormal_foam_cell3.39544718
10MP0005083_abnormal_biliary_tract3.15521345
11MP0003195_calcinosis2.91459812
12* MP0005332_abnormal_amino_acid2.76200901
13MP0001666_abnormal_nutrient_absorption2.61784830
14MP0003191_abnormal_cellular_cholesterol2.40293924
15* MP0000609_abnormal_liver_physiology2.14079630
16MP0004019_abnormal_vitamin_homeostasis2.13925143
17MP0002118_abnormal_lipid_homeostasis2.11686942
18MP0002138_abnormal_hepatobiliary_system2.05907574
19MP0003868_abnormal_feces_composition1.97339144
20MP0005319_abnormal_enzyme/_coenzyme1.81829430
21MP0001764_abnormal_homeostasis1.71057821
22MP0005451_abnormal_body_composition1.67320653
23MP0005584_abnormal_enzyme/coenzyme_acti1.57637930
24MP0009697_abnormal_copulation1.55945480
25MP0003011_delayed_dark_adaptation1.37192290
26MP0003186_abnormal_redox_activity1.29388396
27MP0003656_abnormal_erythrocyte_physiolo1.26049375
28MP0009643_abnormal_urine_homeostasis1.25194052
29MP0003705_abnormal_hypodermis_morpholog1.18487147
30MP0002132_abnormal_respiratory_system1.17456340
31* MP0000598_abnormal_liver_morphology1.16316537
32MP0000604_amyloidosis1.11218582
33MP0005647_abnormal_sex_gland1.06003198
34MP0009764_decreased_sensitivity_to1.04292959
35MP0009763_increased_sensitivity_to1.02577889
36MP0002254_reproductive_system_inflammat1.00165460
37MP0005636_abnormal_mineral_homeostasis0.91361215
38MP0010368_abnormal_lymphatic_system0.91020413
39MP0001915_intracranial_hemorrhage0.90167318
40MP0005670_abnormal_white_adipose0.88466298
41MP0008469_abnormal_protein_level0.87705101
42* MP0009642_abnormal_blood_homeostasis0.87009426
43MP0005408_hypopigmentation0.86386027
44MP0006036_abnormal_mitochondrial_physio0.82646237
45MP0002078_abnormal_glucose_homeostasis0.81254474
46MP0005376_homeostasis/metabolism_phenot0.80832273
47MP0009765_abnormal_xenobiotic_induced0.79309266
48MP0005084_abnormal_gallbladder_morpholo0.78044532
49MP0002282_abnormal_trachea_morphology0.76612879
50MP0005220_abnormal_exocrine_pancreas0.75802111
51MP0003879_abnormal_hair_cell0.74905014
52MP0002876_abnormal_thyroid_physiology0.74324867
53MP0002971_abnormal_brown_adipose0.73716505
54MP0004130_abnormal_muscle_cell0.70541285
55MP0001661_extended_life_span0.70243241
56MP0005334_abnormal_fat_pad0.69404266
57MP0003690_abnormal_glial_cell0.68982073
58MP0005535_abnormal_body_temperature0.66724316
59MP0003329_amyloid_beta_deposits0.65499331
60MP0002249_abnormal_larynx_morphology0.65461000
61MP0009053_abnormal_anal_canal0.65232073
62MP0005266_abnormal_metabolism0.65120167
63MP0001756_abnormal_urination0.62995326
64MP0000639_abnormal_adrenal_gland0.62890764
65MP0005187_abnormal_penis_morphology0.62273833
66MP0000566_synostosis0.61509853
67MP0005448_abnormal_energy_balance0.58299022
68MP0006035_abnormal_mitochondrial_morpho0.56304821
69MP0005023_abnormal_wound_healing0.55966551
70MP0005464_abnormal_platelet_physiology0.55117364
71MP0005395_other_phenotype0.49592149
72MP0003638_abnormal_response/metabolism_0.48170003
73MP0002822_catalepsy0.47253784
74MP0002837_dystrophic_cardiac_calcinosis0.46982891
75MP0008874_decreased_physiological_sensi0.46525171
76MP0008873_increased_physiological_sensi0.45520813
77MP0002136_abnormal_kidney_physiology0.45098813
78MP0002928_abnormal_bile_duct0.44875356
79MP0003718_maternal_effect0.44657030
80MP0005248_abnormal_Harderian_gland0.43347726
81MP0009785_altered_susceptibility_to0.42342391
82MP0003436_decreased_susceptibility_to0.42226080
83MP0003953_abnormal_hormone_level0.42208575
84MP0004782_abnormal_surfactant_physiolog0.41461862
85MP0005666_abnormal_adipose_tissue0.39915858
86MP0003724_increased_susceptibility_to0.39769205
87MP0003075_altered_response_to0.39721851
88MP0008872_abnormal_physiological_respon0.37373697
89MP0009672_abnormal_birth_weight0.36990802
90MP0002089_abnormal_postnatal_growth/wei0.36226511
91MP0000230_abnormal_systemic_arterial0.34749105
92MP0001243_abnormal_dermal_layer0.33613711
93MP0004883_abnormal_blood_vessel0.33239814
94MP0000249_abnormal_blood_vessel0.33135774
95MP0009115_abnormal_fat_cell0.33085623
96MP0002168_other_aberrant_phenotype0.33050167
97MP0005166_decreased_susceptibility_to0.32975701
98MP0000467_abnormal_esophagus_morphology0.32038448
99MP0002970_abnormal_white_adipose0.30871693
100MP0000579_abnormal_nail_morphology0.29940786
101MP0001853_heart_inflammation0.29164350
102MP0006082_CNS_inflammation0.28787795
103MP0002796_impaired_skin_barrier0.26903317
104MP0004381_abnormal_hair_follicle0.26902509
105MP0001881_abnormal_mammary_gland0.26438029
106* MP0001845_abnormal_inflammatory_respons0.25817556
107MP0005377_hearing/vestibular/ear_phenot0.25314924
108MP0003878_abnormal_ear_physiology0.25314924
109MP0002090_abnormal_vision0.25277270
110MP0005164_abnormal_response_to0.25092404
111MP0009384_cardiac_valve_regurgitation0.24511702
112MP0001851_eye_inflammation0.24135657
113MP0005058_abnormal_lysosome_morphology0.23385151
114MP0001944_abnormal_pancreas_morphology0.22844712
115MP0003632_abnormal_nervous_system0.21430652
116MP0002909_abnormal_adrenal_gland0.19809206
117MP0000920_abnormal_myelination0.19010690
118MP0003172_abnormal_lysosome_physiology0.18611979
119MP0002128_abnormal_blood_circulation0.17851947
120MP0005197_abnormal_uvea_morphology0.17496323

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.67940721
2Deep venous thrombosis (HP:0002625)7.36547702
3Intrahepatic cholestasis (HP:0001406)7.10844843
4Abnormality of monocarboxylic acid metabolism (HP:0010996)7.02650183
5Hypobetalipoproteinemia (HP:0003563)6.50396517
6Prolonged partial thromboplastin time (HP:0003645)6.47842473
7Xanthomatosis (HP:0000991)6.32721746
8Hyperlipoproteinemia (HP:0010980)5.73201038
9Complement deficiency (HP:0004431)4.97789676
10Hypolipoproteinemia (HP:0010981)4.88634883
11Hyperammonemia (HP:0001987)4.76846600
12Joint hemorrhage (HP:0005261)4.76581324
13Epidermoid cyst (HP:0200040)4.57401641
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48678883
15Abnormality of the common coagulation pathway (HP:0010990)4.47643119
16Hyperglycinemia (HP:0002154)4.38650110
17Ketosis (HP:0001946)4.34717091
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32902566
19Hypoalphalipoproteinemia (HP:0003233)4.31635604
20Abnormality of pyrimidine metabolism (HP:0004353)4.14510055
21* Abnormality of sulfur amino acid metabolism (HP:0004339)4.07833816
22Fat malabsorption (HP:0002630)4.01551157
23* Abnormality of methionine metabolism (HP:0010901)3.95235665
24Hyperglycinuria (HP:0003108)3.93667194
25Hypoglycemic coma (HP:0001325)3.93060411
26Abnormality of serine family amino acid metabolism (HP:0010894)3.90833229
27Abnormality of glycine metabolism (HP:0010895)3.90833229
28* Abnormality of aspartate family amino acid metabolism (HP:0010899)3.88887392
29Abnormality of the intrinsic pathway (HP:0010989)3.71959284
30Hypercholesterolemia (HP:0003124)3.69336154
31Abnormality of complement system (HP:0005339)3.62358991
32Conjugated hyperbilirubinemia (HP:0002908)3.61293311
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.43490144
34Abnormality of fatty-acid metabolism (HP:0004359)3.39770251
35Hyperbilirubinemia (HP:0002904)3.35790719
36Abnormality of nucleobase metabolism (HP:0010932)3.18345520
37Abnormality of serum amino acid levels (HP:0003112)3.17001946
38Delayed CNS myelination (HP:0002188)3.10508948
39Spontaneous abortion (HP:0005268)3.07659082
40Ketoacidosis (HP:0001993)3.06205091
41Steatorrhea (HP:0002570)2.99084428
42Hepatocellular carcinoma (HP:0001402)2.97450867
43Myocardial infarction (HP:0001658)2.88360425
44Hypochromic microcytic anemia (HP:0004840)2.85170002
45Skin nodule (HP:0200036)2.84587111
46Metabolic acidosis (HP:0001942)2.82969435
47Abnormality of purine metabolism (HP:0004352)2.70263253
48Osteomalacia (HP:0002749)2.70239583
49Purpura (HP:0000979)2.68743162
50Lethargy (HP:0001254)2.68473543
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62464047
52Dicarboxylic aciduria (HP:0003215)2.62464047
53Vascular calcification (HP:0004934)2.58890415
54Cerebral edema (HP:0002181)2.56519241
55Spastic diplegia (HP:0001264)2.54692076
56Acanthocytosis (HP:0001927)2.54021865
57Systemic lupus erythematosus (HP:0002725)2.53031030
58Hypoglycemic seizures (HP:0002173)2.51496334
59Glomerulonephritis (HP:0000099)2.50021156
60Irritability (HP:0000737)2.45560795
61Gout (HP:0001997)2.44938755
62Mitral stenosis (HP:0001718)2.42451892
63Abnormal gallbladder morphology (HP:0012437)2.40487246
64Neonatal onset (HP:0003623)2.38976558
65Amyloidosis (HP:0011034)2.36777286
66Cholelithiasis (HP:0001081)2.33904490
67Pulmonary embolism (HP:0002204)2.32974649
68Fair hair (HP:0002286)2.31226917
69Malnutrition (HP:0004395)2.30277487
70Cardiovascular calcification (HP:0011915)2.29494992
71Abnormal gallbladder physiology (HP:0012438)2.27920929
72Cholecystitis (HP:0001082)2.27920929
73Gingival bleeding (HP:0000225)2.24036479
74Neonatal hypoglycemia (HP:0001998)2.22771390
75Esophageal varix (HP:0002040)2.19036715
76Menorrhagia (HP:0000132)2.16762492
77Pancreatitis (HP:0001733)2.16489384
78Brushfield spots (HP:0001088)2.16448322
79Late onset (HP:0003584)2.15829306
80Enlarged kidneys (HP:0000105)2.12362080
81Vomiting (HP:0002013)2.11670157
82Sensorimotor neuropathy (HP:0007141)2.10336859
83Thrombophlebitis (HP:0004418)2.09489678
84Generalized aminoaciduria (HP:0002909)2.08126347
85Hyperinsulinemic hypoglycemia (HP:0000825)2.06653073
86Recurrent gram-negative bacterial infections (HP:0005420)2.05832307
87Opisthotonus (HP:0002179)2.02204989
88Joint swelling (HP:0001386)2.00042219
89Hyperphosphaturia (HP:0003109)1.99995726
90Poikilocytosis (HP:0004447)1.99992581
91Alkalosis (HP:0001948)1.99619700
92Abnormality of vitamin metabolism (HP:0100508)1.97142005
93Arthropathy (HP:0003040)1.96590928
94Reduced antithrombin III activity (HP:0001976)1.95837302
95Abnormality of the gallbladder (HP:0005264)1.93941701
96Hemorrhage of the eye (HP:0011885)1.93522741
97Abnormality of the Achilles tendon (HP:0005109)1.93094476
98Rickets (HP:0002748)1.90077971
99Elevated alkaline phosphatase (HP:0003155)1.90013124
100Abnormality of iron homeostasis (HP:0011031)1.89199732
101Abnormal cartilage morphology (HP:0002763)1.88653670
102Renal cortical cysts (HP:0000803)1.87858026
103Bifid scrotum (HP:0000048)1.87191235
104Abnormality of transition element cation homeostasis (HP:0011030)1.86481454
105Increased serum ferritin (HP:0003281)1.85902510
106Abnormality of proline metabolism (HP:0010907)1.85123814
107Hydroxyprolinuria (HP:0003080)1.85123814
108Abnormality of urine glucose concentration (HP:0011016)1.83648665
109Glycosuria (HP:0003076)1.83648665
110Elevated hepatic transaminases (HP:0002910)1.82551641
111Hypophosphatemic rickets (HP:0004912)1.82133230
112Status epilepticus (HP:0002133)1.80778050
113Gangrene (HP:0100758)1.79015690
114Epistaxis (HP:0000421)1.77358148
115Hyperglycemia (HP:0003074)1.77258498
116Increased mean platelet volume (HP:0011877)1.75776929
117Abnormality of alkaline phosphatase activity (HP:0004379)1.75349301
118Proximal tubulopathy (HP:0000114)1.75348815
119Nephritis (HP:0000123)1.75060828
120Abnormal enzyme/coenzyme activity (HP:0012379)1.73911622
121Abnormal urine phosphate concentration (HP:0012599)1.64179888
122Abnormal delivery (HP:0001787)1.63811290
123Generalized hypopigmentation of hair (HP:0011358)1.57543628
124Abnormal platelet volume (HP:0011876)1.57236359
125Abnormal platelet function (HP:0011869)1.54741278
126Impaired platelet aggregation (HP:0003540)1.54741278
127Increased serum pyruvate (HP:0003542)1.52384965
128Cerebral palsy (HP:0100021)1.52208932
129Reticulocytosis (HP:0001923)1.50521750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.34871217
2FGFR44.49081026
3SIK14.48219841
4ERN14.32310646
5INSRR3.18701618
6TAOK33.02335561
7ERBB42.62967151
8PKN22.44336211
9MAP2K42.38390784
10PIK3CA2.21088449
11FLT32.06937958
12MST1R2.02046553
13PIK3CG1.96635598
14TRIB31.87367155
15MAPK111.78565535
16TYK21.64576294
17NTRK31.64187481
18LATS11.64030368
19PRPF4B1.61648001
20FRK1.53984814
21DAPK21.53321672
22PTK61.50741173
23ABL21.48346841
24FGFR21.35402940
25NEK91.33716824
26KDR1.29627728
27NLK1.24508441
28JAK21.20593511
29PINK11.17405884
30MAP3K71.13733278
31PRKAA21.11559780
32MAP2K31.07169551
33GRK61.04271990
34MAP3K101.04067148
35TBK11.03674686
36JAK11.01516177
37MAPK40.97207326
38CDK120.96292324
39ERBB20.95597012
40FER0.93257803
41PRKCZ0.91704952
42EPHB10.91500774
43MAP3K140.90730963
44MAPKAPK30.89698019
45MAP3K30.88950231
46MAPK150.86195119
47EPHA30.85478926
48PDGFRA0.85400420
49MET0.84755200
50PRKG10.84525905
51CDK60.82197349
52MAPK120.81218986
53STK38L0.76982944
54PDK20.76941179
55PRKACG0.76600708
56MAP3K110.76599231
57TIE10.74307255
58DYRK1B0.74172603
59CSK0.71093491
60PRKACA0.70815857
61MAP2K60.69938344
62GSK3A0.68575226
63CAMK2G0.67095363
64CSNK1E0.66785418
65TNK20.66101138
66EEF2K0.66000142
67SGK30.65058805
68PRKAA10.65045088
69MUSK0.64944196
70CAMK1D0.64920295
71AKT30.61421687
72KSR20.61188452
73RIPK10.61168235
74IRAK30.60365139
75MAPK70.59741560
76FGFR30.59707030
77WNK40.59609896
78SGK10.59107053
79PTK20.58854525
80CSNK1D0.58690497
81FGFR10.58122174
82TGFBR20.57091256
83PDPK10.54426606
84CSF1R0.54220547
85IKBKE0.52417407
86MYLK0.52381794
87RPS6KA30.51917755
88PRKCQ0.51318747
89CSNK1G10.50263326
90PRKCB0.48317732
91EIF2AK10.48038223
92ZAP700.47975243
93RET0.47688864
94SGK20.47143792
95EPHA40.47094108
96CAMKK20.46827188
97PRKACB0.46583436
98MAP2K10.45354198
99SRC0.45347050
100MAP3K50.45084248
101STK380.44757003
102IGF1R0.44576384
103EPHA20.43783398
104TAOK20.43173051
105GRK10.41296461
106CDK40.40906508
107SMG10.40039954
108MAP3K130.40007160
109PRKCG0.39889833
110CSNK2A10.38116974
111CSNK2A20.37960463
112SCYL20.37233440
113MAP3K60.37091024
114MTOR0.36401498
115ICK0.36283685
116RPS6KB10.36273027
117MAP3K10.35045930
118PDK10.34677498
119STK160.33899351
120SGK4940.33586992
121SGK2230.33586992
122CAMK40.31115426
123CSNK1G20.31087762
124EGFR0.30796532
125IRAK10.30346029
126PBK0.29922235
127MAP2K20.29533998
128IRAK20.28092354
129CSNK1G30.27919106
130PKN10.27290873
131PRKCA0.25283308
132MAP3K20.24301446
133LATS20.22551065
134PAK30.21539338
135PDK40.20405195
136PDK30.20405195
137ABL10.19671009

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.42287406
2Nitrogen metabolism_Homo sapiens_hsa009103.74515459
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.55969483
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35079381
5Arginine biosynthesis_Homo sapiens_hsa002203.24587881
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71628260
7Complement and coagulation cascades_Homo sapiens_hsa046102.66952549
8Tryptophan metabolism_Homo sapiens_hsa003802.66278031
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62904954
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60241799
11Fatty acid degradation_Homo sapiens_hsa000712.49933784
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39496710
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24321573
14Butanoate metabolism_Homo sapiens_hsa006502.13730815
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09604942
16Peroxisome_Homo sapiens_hsa041462.06022935
17Propanoate metabolism_Homo sapiens_hsa006401.93059906
18Histidine metabolism_Homo sapiens_hsa003401.92848849
19Chemical carcinogenesis_Homo sapiens_hsa052041.90957416
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87992445
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.86329924
22PPAR signaling pathway_Homo sapiens_hsa033201.86115819
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.84953333
24Fatty acid metabolism_Homo sapiens_hsa012121.79872557
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.75694662
26beta-Alanine metabolism_Homo sapiens_hsa004101.73676014
27Staphylococcus aureus infection_Homo sapiens_hsa051501.71961381
28Caffeine metabolism_Homo sapiens_hsa002321.66105309
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65311181
30Retinol metabolism_Homo sapiens_hsa008301.63826847
31Phenylalanine metabolism_Homo sapiens_hsa003601.62692077
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62084217
33Selenocompound metabolism_Homo sapiens_hsa004501.60235781
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55806070
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55201547
36Bile secretion_Homo sapiens_hsa049761.45033405
37Tyrosine metabolism_Homo sapiens_hsa003501.44691874
38Sulfur metabolism_Homo sapiens_hsa009201.35548869
39Pyruvate metabolism_Homo sapiens_hsa006201.35283163
40Fatty acid elongation_Homo sapiens_hsa000621.30976823
41* Cysteine and methionine metabolism_Homo sapiens_hsa002701.29984329
42Starch and sucrose metabolism_Homo sapiens_hsa005001.24625996
43Folate biosynthesis_Homo sapiens_hsa007901.22375592
44* Biosynthesis of amino acids_Homo sapiens_hsa012301.19172391
45Fat digestion and absorption_Homo sapiens_hsa049751.17408716
46ABC transporters_Homo sapiens_hsa020101.16759066
47Steroid biosynthesis_Homo sapiens_hsa001001.13569828
48Carbon metabolism_Homo sapiens_hsa012001.13265339
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.04367651
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01666893
51Arginine and proline metabolism_Homo sapiens_hsa003301.00052980
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.96535162
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95647919
54Sulfur relay system_Homo sapiens_hsa041220.92467038
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87479803
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86125041
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84317417
58Vitamin B6 metabolism_Homo sapiens_hsa007500.83214712
59Lysine degradation_Homo sapiens_hsa003100.82682641
60One carbon pool by folate_Homo sapiens_hsa006700.75394874
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69362040
62Glycerolipid metabolism_Homo sapiens_hsa005610.67714578
63Glutathione metabolism_Homo sapiens_hsa004800.60293370
64Pentose phosphate pathway_Homo sapiens_hsa000300.57380133
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49204459
66Fatty acid biosynthesis_Homo sapiens_hsa000610.49108500
67* Metabolic pathways_Homo sapiens_hsa011000.45556033
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32857993
69Prion diseases_Homo sapiens_hsa050200.26601804
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25560687
71Fructose and mannose metabolism_Homo sapiens_hsa000510.24843209
72Insulin resistance_Homo sapiens_hsa049310.23479624
73Galactose metabolism_Homo sapiens_hsa000520.23342774
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.22232605
75Linoleic acid metabolism_Homo sapiens_hsa005910.21889182
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18449161
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.15399964
78Other glycan degradation_Homo sapiens_hsa005110.11710890
79Glucagon signaling pathway_Homo sapiens_hsa049220.11089323
80AMPK signaling pathway_Homo sapiens_hsa041520.02947706
81Pertussis_Homo sapiens_hsa05133-0.2594600
82Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2593753
83Ether lipid metabolism_Homo sapiens_hsa00565-0.2548064
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2346098
85Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2286438
86Type II diabetes mellitus_Homo sapiens_hsa04930-0.2216277
87Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2085653
88Circadian rhythm_Homo sapiens_hsa04710-0.2009820
89N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1950043
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1940024
91Hepatitis C_Homo sapiens_hsa05160-0.1899152
92Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1855837
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1792209
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1786483
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1695298
96Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1672919
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1665175
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1531946
99African trypanosomiasis_Homo sapiens_hsa05143-0.1513874
100Sphingolipid metabolism_Homo sapiens_hsa00600-0.1403185
101Regulation of autophagy_Homo sapiens_hsa04140-0.1324592
102Insulin signaling pathway_Homo sapiens_hsa04910-0.0967097
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0926118
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0761770
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0746974
106Serotonergic synapse_Homo sapiens_hsa04726-0.0696819
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0419762
108Amoebiasis_Homo sapiens_hsa05146-0.0258958
109Mineral absorption_Homo sapiens_hsa04978-0.0007417

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