MAT2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.96077397
2nucleobase biosynthetic process (GO:0046112)5.80952575
3pore complex assembly (GO:0046931)5.38021197
4ribosome assembly (GO:0042255)5.13237427
5DNA unwinding involved in DNA replication (GO:0006268)4.85346976
6mitotic metaphase plate congression (GO:0007080)4.63540883
7DNA replication initiation (GO:0006270)4.62947074
8ribosome biogenesis (GO:0042254)4.61132887
9DNA topological change (GO:0006265)4.55071541
10regulation of spindle organization (GO:0090224)4.51093320
11regulation of centriole replication (GO:0046599)4.48811266
12DNA strand elongation involved in DNA replication (GO:0006271)4.47607733
13DNA strand elongation (GO:0022616)4.27574806
14IMP biosynthetic process (GO:0006188)4.24533896
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.20481656
16regulation of translational fidelity (GO:0006450)4.19069830
17DNA replication checkpoint (GO:0000076)4.15517511
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.11797482
19vitamin transmembrane transport (GO:0035461)4.03505068
20spliceosomal tri-snRNP complex assembly (GO:0000244)3.99877170
21protein localization to kinetochore (GO:0034501)3.99774939
22GMP metabolic process (GO:0046037)3.97572399
23metaphase plate congression (GO:0051310)3.89850985
24folic acid metabolic process (GO:0046655)3.89086762
25sister chromatid segregation (GO:0000819)3.88269699
26nuclear pore organization (GO:0006999)3.86746858
27mitotic nuclear envelope disassembly (GO:0007077)3.86623783
28mitotic sister chromatid cohesion (GO:0007064)3.83641970
29CENP-A containing nucleosome assembly (GO:0034080)3.82605439
30mitotic sister chromatid segregation (GO:0000070)3.80411773
31telomere maintenance via semi-conservative replication (GO:0032201)3.79877864
32regulation of nucleobase-containing compound transport (GO:0032239)3.74841888
33maturation of SSU-rRNA (GO:0030490)3.71233714
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.67895813
35DNA replication-independent nucleosome organization (GO:0034724)3.67261797
36DNA replication-independent nucleosome assembly (GO:0006336)3.67261797
37spliceosomal snRNP assembly (GO:0000387)3.65238493
38IMP metabolic process (GO:0046040)3.64550506
39negative regulation of mRNA metabolic process (GO:1903312)3.64488825
40ribonucleoprotein complex biogenesis (GO:0022613)3.64088675
41formation of translation preinitiation complex (GO:0001731)3.63690432
42peptidyl-arginine omega-N-methylation (GO:0035247)3.62785154
43chromatin remodeling at centromere (GO:0031055)3.62783167
44rRNA processing (GO:0006364)3.61489204
45DNA replication-dependent nucleosome organization (GO:0034723)3.59458184
46DNA replication-dependent nucleosome assembly (GO:0006335)3.59458184
47termination of RNA polymerase III transcription (GO:0006386)3.56871126
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.56871126
49dosage compensation (GO:0007549)3.56611261
50membrane disassembly (GO:0030397)3.55917754
51nuclear envelope disassembly (GO:0051081)3.55917754
52regulation of mitotic spindle organization (GO:0060236)3.54411975
53transcription elongation from RNA polymerase I promoter (GO:0006362)3.51921465
54negative regulation of histone methylation (GO:0031061)3.51803094
55pseudouridine synthesis (GO:0001522)3.49575496
56termination of RNA polymerase I transcription (GO:0006363)3.48525049
57rRNA metabolic process (GO:0016072)3.48478811
58nuclear pore complex assembly (GO:0051292)3.47147996
59positive regulation of chromosome segregation (GO:0051984)3.45400578
60glucocorticoid receptor signaling pathway (GO:0042921)3.45262043
61DNA deamination (GO:0045006)3.41508558
62spindle checkpoint (GO:0031577)3.39205915
63attachment of spindle microtubules to kinetochore (GO:0008608)3.38973547
64protein localization to chromosome, centromeric region (GO:0071459)3.38437135
65regulation of histone H3-K27 methylation (GO:0061085)3.35866054
66mitotic spindle checkpoint (GO:0071174)3.35396449
67rRNA modification (GO:0000154)3.34668647
68telomere maintenance via recombination (GO:0000722)3.33833064
69mitotic recombination (GO:0006312)3.32985013
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.32218691
71negative regulation of sister chromatid segregation (GO:0033046)3.32218691
72negative regulation of mitotic sister chromatid separation (GO:2000816)3.32218691
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.32218691
74negative regulation of chromosome segregation (GO:0051985)3.32154765
75homocysteine metabolic process (GO:0050667)3.30771166
76mRNA transport (GO:0051028)3.29852658
77histone exchange (GO:0043486)3.28985151
78mitotic spindle assembly checkpoint (GO:0007094)3.28915979
79DNA synthesis involved in DNA repair (GO:0000731)3.27667743
80spindle assembly checkpoint (GO:0071173)3.27345252
81regulation of centrosome duplication (GO:0010824)3.27310976
82RNA stabilization (GO:0043489)3.26599594
83mRNA stabilization (GO:0048255)3.26599594
84DNA conformation change (GO:0071103)3.26517614
85negative regulation of mRNA processing (GO:0050686)3.25744554
86transcription from RNA polymerase I promoter (GO:0006360)3.23002337
87mRNA export from nucleus (GO:0006406)3.21295787
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20592901
89regulation of DNA damage checkpoint (GO:2000001)3.19930858
90telomere maintenance via telomere lengthening (GO:0010833)3.19913622
91regulation of RNA export from nucleus (GO:0046831)3.19892912
92heterochromatin organization (GO:0070828)3.19110277
93regulation of chromosome segregation (GO:0051983)3.18287552
94transcription initiation from RNA polymerase I promoter (GO:0006361)3.18103441
95protein export from nucleus (GO:0006611)3.17559154
96translesion synthesis (GO:0019985)3.17551227
97negative regulation of RNA splicing (GO:0033119)3.17298763
98RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.16886453
99mRNA splicing, via spliceosome (GO:0000398)3.16886453
100RNA export from nucleus (GO:0006405)3.15981972
101positive regulation of p38MAPK cascade (GO:1900745)3.15446746
102atrioventricular valve morphogenesis (GO:0003181)3.14726748
103RNA splicing, via transesterification reactions (GO:0000375)3.14378569
104nucleosome disassembly (GO:0006337)3.13042709
105protein-DNA complex disassembly (GO:0032986)3.13042709
106maturation of 5.8S rRNA (GO:0000460)3.12777869
107viral mRNA export from host cell nucleus (GO:0046784)3.12372041
108transcription-coupled nucleotide-excision repair (GO:0006283)3.11064668
109peptidyl-arginine N-methylation (GO:0035246)3.09920078
110peptidyl-arginine methylation (GO:0018216)3.09920078
111pre-miRNA processing (GO:0031054)3.09534179
112histone-serine phosphorylation (GO:0035404)3.09292976
113regulation of chromatin binding (GO:0035561)3.09232297
1147-methylguanosine mRNA capping (GO:0006370)3.08740185
115DNA-templated transcription, termination (GO:0006353)3.07621683
116nuclear envelope organization (GO:0006998)3.07259213
117Golgi transport vesicle coating (GO:0048200)3.06496078
118COPI coating of Golgi vesicle (GO:0048205)3.06496078
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06428525
120RNA capping (GO:0036260)3.06091334
1217-methylguanosine RNA capping (GO:0009452)3.06091334
122establishment of chromosome localization (GO:0051303)3.05566266
123regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02808678
124nucleotide-excision repair, DNA gap filling (GO:0006297)3.02434670
125negative regulation of fibroblast apoptotic process (GO:2000270)3.02349820
126positive regulation of cell cycle checkpoint (GO:1901978)3.01613034
127ribosomal large subunit biogenesis (GO:0042273)2.99243904
128mitotic chromosome condensation (GO:0007076)2.99135386
129regulation of centrosome cycle (GO:0046605)2.97966491
130DNA duplex unwinding (GO:0032508)2.97075285
131regulation of sister chromatid cohesion (GO:0007063)2.95279169
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95127330
133DNA geometric change (GO:0032392)2.95126389
134regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94493522
135histone arginine methylation (GO:0034969)2.93802848
136chromosome condensation (GO:0030261)2.92336489
137RNA transport (GO:0050658)2.92111588
138establishment of RNA localization (GO:0051236)2.92111588
139nucleic acid transport (GO:0050657)2.92111588
140proteasome assembly (GO:0043248)2.91400804
141G1/S transition of mitotic cell cycle (GO:0000082)2.90981048
142cell cycle G1/S phase transition (GO:0044843)2.90981048
143folic acid-containing compound biosynthetic process (GO:0009396)2.90526693
144L-serine metabolic process (GO:0006563)2.90483523
145regulation of histone H3-K9 methylation (GO:0051570)2.89696169
146ncRNA processing (GO:0034470)2.88346916
147midgut development (GO:0007494)2.87663402
148termination of RNA polymerase II transcription (GO:0006369)2.85929509
149definitive hemopoiesis (GO:0060216)2.84720972
150nuclear export (GO:0051168)2.82325364
151regulation of mRNA stability (GO:0043488)2.80625069
152hepatocyte differentiation (GO:0070365)2.80378018
153tRNA aminoacylation for protein translation (GO:0006418)2.80331194
154non-recombinational repair (GO:0000726)2.78082017
155double-strand break repair via nonhomologous end joining (GO:0006303)2.78082017
156meiotic chromosome segregation (GO:0045132)2.77430712
157positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77287148
158positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77287148
159positive regulation of mitotic sister chromatid separation (GO:1901970)2.77287148
160regulation of NFAT protein import into nucleus (GO:0051532)2.75469346
161cellular protein complex localization (GO:0034629)2.74471369
162stress granule assembly (GO:0034063)2.70469230
163somatic hypermutation of immunoglobulin genes (GO:0016446)2.70136733
164somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70136733
165glutamine metabolic process (GO:0006541)2.69659476
166proline biosynthetic process (GO:0006561)2.68162924
167positive regulation of odontogenesis (GO:0042482)2.66679537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.93199354
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.59983193
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.87666740
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.78919236
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47086246
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36737255
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18916167
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.06075560
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04720564
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.04657769
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01986608
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99209339
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96651112
14AR_21909140_ChIP-Seq_LNCAP_Human2.96427667
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.94602367
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83449325
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.70795878
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.57174507
19* XRN2_22483619_ChIP-Seq_HELA_Human2.47648700
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41610130
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31372974
22* VDR_23849224_ChIP-Seq_CD4+_Human2.31116716
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27540699
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27535773
25* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22425345
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16550969
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.13769437
28* E2F1_21310950_ChIP-Seq_MCF-7_Human2.08396830
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04897572
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01606261
31GABP_19822575_ChIP-Seq_HepG2_Human2.00623318
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96901482
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96439341
34FOXP3_21729870_ChIP-Seq_TREG_Human1.95732658
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91287942
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89809789
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89131159
38* DCP1A_22483619_ChIP-Seq_HELA_Human1.87257259
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85271608
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.81197080
41* TTF2_22483619_ChIP-Seq_HELA_Human1.80512598
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79459277
43VDR_21846776_ChIP-Seq_THP-1_Human1.79290859
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78670048
45CIITA_25753668_ChIP-Seq_RAJI_Human1.75447959
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72095974
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70888204
48KDM5A_27292631_Chip-Seq_BREAST_Human1.64129698
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56855710
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54167143
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50097482
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.46584141
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45460276
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44998521
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.43947660
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.40897341
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.40469483
58ELK1_19687146_ChIP-ChIP_HELA_Human1.40467158
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39302138
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37759990
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37161315
62* MYC_22102868_ChIP-Seq_BL_Human1.37148148
63* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35101776
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34039559
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.33772432
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31890227
67* TCF7_22412390_ChIP-Seq_EML_Mouse1.31810419
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30614098
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29840085
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27473214
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27182165
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26374891
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23171397
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22913244
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21755394
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21557529
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21168583
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19015221
79* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18672222
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17399221
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16555957
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.16473535
83* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14618209
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14255846
85NCOR1_26117541_ChIP-Seq_K562_Human1.13733385
86* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12535259
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12140843
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.10935565
89* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09807945
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08306990
91* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07433916
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06594855
93KDM2B_26808549_Chip-Seq_DND41_Human1.06352118
94* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05171211
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04044252
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02291760
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00833496
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00208148
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99755065
100RACK7_27058665_Chip-Seq_MCF-7_Human0.99725619
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99326817
102ZNF263_19887448_ChIP-Seq_K562_Human0.99274211
103TFEB_21752829_ChIP-Seq_HELA_Human0.99196530
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98777090
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98578010
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97240460
107* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96996161
108CREB1_26743006_Chip-Seq_LNCaP_Human0.95523226
109* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94035498
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94000590
111MYC_18940864_ChIP-ChIP_HL60_Human0.92809599
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.92193041
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91862462
114* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91110193
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90923108
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90105454
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88440143
118ATF3_27146783_Chip-Seq_COLON_Human0.87875280
119* UBF1/2_26484160_Chip-Seq_HMECs_Human0.87178283
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85718772
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85524048
122* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84704648
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79986857
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77750398
125* CHD1_26751641_Chip-Seq_LNCaP_Human0.76052314
126TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.75894438
127CLOCK_20551151_ChIP-Seq_293T_Human0.75702343
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.75516997
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75499308
130* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74754607
131* SOX17_20123909_ChIP-Seq_XEN_Mouse0.74500683
132TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73381379
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72656177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.31417626
2MP0010094_abnormal_chromosome_stability4.64097919
3MP0003111_abnormal_nucleus_morphology4.46614140
4MP0004957_abnormal_blastocyst_morpholog4.17266266
5MP0008057_abnormal_DNA_replication3.84185171
6MP0003077_abnormal_cell_cycle3.72527117
7MP0005083_abnormal_biliary_tract3.36576212
8MP0008058_abnormal_DNA_repair3.13698400
9MP0008007_abnormal_cellular_replicative2.81419210
10MP0003123_paternal_imprinting2.74525274
11MP0002396_abnormal_hematopoietic_system2.68717400
12MP0008932_abnormal_embryonic_tissue2.61438639
13MP0005377_hearing/vestibular/ear_phenot2.58706144
14MP0003878_abnormal_ear_physiology2.58706144
15MP0001730_embryonic_growth_arrest2.52182535
16MP0003786_premature_aging2.26482616
17MP0000350_abnormal_cell_proliferation2.26311385
18MP0005076_abnormal_cell_differentiation2.13529581
19MP0003718_maternal_effect2.12120229
20MP0008877_abnormal_DNA_methylation2.05996540
21MP0002009_preneoplasia1.88375386
22MP0003705_abnormal_hypodermis_morpholog1.78291144
23MP0001697_abnormal_embryo_size1.76867701
24MP0001672_abnormal_embryogenesis/_devel1.74716171
25MP0005380_embryogenesis_phenotype1.74716171
26MP0004147_increased_porphyrin_level1.73739161
27MP0003950_abnormal_plasma_membrane1.71785575
28MP0002080_prenatal_lethality1.67663076
29MP0001293_anophthalmia1.65104667
30MP0003984_embryonic_growth_retardation1.60676537
31MP0001661_extended_life_span1.59274245
32MP0004885_abnormal_endolymph1.58336712
33MP0000003_abnormal_adipose_tissue1.55949776
34MP0002877_abnormal_melanocyte_morpholog1.55714242
35MP0002088_abnormal_embryonic_growth/wei1.55157633
36MP0002085_abnormal_embryonic_tissue1.52240974
37MP0010307_abnormal_tumor_latency1.51535037
38MP0003567_abnormal_fetal_cardiomyocyte1.49255091
39MP0002084_abnormal_developmental_patter1.42870560
40MP0004185_abnormal_adipocyte_glucose1.42501180
41MP0008260_abnormal_autophagy1.37020224
42MP0000313_abnormal_cell_death1.36577717
43MP0005220_abnormal_exocrine_pancreas1.32469336
44MP0001545_abnormal_hematopoietic_system1.32178970
45MP0005397_hematopoietic_system_phenotyp1.32178970
46MP0005423_abnormal_somatic_nervous1.29428142
47MP0003221_abnormal_cardiomyocyte_apopto1.26067805
48MP0001348_abnormal_lacrimal_gland1.24771412
49MP0002210_abnormal_sex_determination1.23773706
50MP0004808_abnormal_hematopoietic_stem1.23394336
51MP0002086_abnormal_extraembryonic_tissu1.22903616
52MP0001485_abnormal_pinna_reflex1.20991234
53MP0006072_abnormal_retinal_apoptosis1.19862268
54MP0001145_abnormal_male_reproductive1.18354172
55MP0004197_abnormal_fetal_growth/weight/1.17060913
56MP0010030_abnormal_orbit_morphology1.16813971
57MP0005499_abnormal_olfactory_system1.16149076
58MP0005394_taste/olfaction_phenotype1.16149076
59MP0009672_abnormal_birth_weight1.15800798
60MP0005551_abnormal_eye_electrophysiolog1.15681531
61MP0001346_abnormal_lacrimal_gland1.15176266
62MP0000537_abnormal_urethra_morphology1.13064370
63MP0002697_abnormal_eye_size1.12476943
64MP0008789_abnormal_olfactory_epithelium1.11751341
65MP0003937_abnormal_limbs/digits/tail_de1.09373514
66MP0003121_genomic_imprinting1.08183813
67MP0002653_abnormal_ependyma_morphology1.07180935
68MP0000579_abnormal_nail_morphology1.06755360
69MP0005501_abnormal_skin_physiology1.06178892
70MP0009333_abnormal_splenocyte_physiolog1.05385808
71MP0000747_muscle_weakness1.04627807
72MP0003385_abnormal_body_wall1.04524363
73MP0002269_muscular_atrophy1.04102784
74MP0004858_abnormal_nervous_system1.04019243
75MP0000490_abnormal_crypts_of1.03456516
76MP0003566_abnormal_cell_adhesion1.02856357
77MP0004782_abnormal_surfactant_physiolog1.00089399
78MP0010630_abnormal_cardiac_muscle0.99692536
79MP0001849_ear_inflammation0.99603438
80MP0000428_abnormal_craniofacial_morphol0.98730504
81MP0003315_abnormal_perineum_morphology0.97396532
82MP0004233_abnormal_muscle_weight0.97324339
83MP0000653_abnormal_sex_gland0.95478084
84MP0000751_myopathy0.94602211
85MP0004084_abnormal_cardiac_muscle0.93190695
86MP0002019_abnormal_tumor_incidence0.91924771
87MP0004087_abnormal_muscle_fiber0.91573596
88MP0005623_abnormal_meninges_morphology0.91135916
89MP0001929_abnormal_gametogenesis0.90156551
90MP0002102_abnormal_ear_morphology0.89525200
91MP0005391_vision/eye_phenotype0.87971000
92MP0002092_abnormal_eye_morphology0.87209912
93MP0010352_gastrointestinal_tract_polyps0.87053411
94MP0003943_abnormal_hepatobiliary_system0.86019905
95MP0000759_abnormal_skeletal_muscle0.85134947
96MP0000762_abnormal_tongue_morphology0.84946708
97MP0005375_adipose_tissue_phenotype0.84666325
98MP0002938_white_spotting0.84483255
99MP0006292_abnormal_olfactory_placode0.84438655
100MP0000750_abnormal_muscle_regeneration0.83909423
101MP0001188_hyperpigmentation0.83740281
102MP0000383_abnormal_hair_follicle0.81702334
103MP0001340_abnormal_eyelid_morphology0.81122998
104MP0000733_abnormal_muscle_development0.80089790
105MP0003935_abnormal_craniofacial_develop0.79427018
106MP0000465_gastrointestinal_hemorrhage0.78605522
107MP0009703_decreased_birth_body0.78260123
108MP0000432_abnormal_head_morphology0.77369528
109MP0005384_cellular_phenotype0.77049297
110MP0003938_abnormal_ear_development0.76372139
111MP0009250_abnormal_appendicular_skeleto0.74633875
112MP0005253_abnormal_eye_physiology0.73563946
113MP0002111_abnormal_tail_morphology0.73391565
114MP0005621_abnormal_cell_physiology0.72079398
115MP0002081_perinatal_lethality0.71389787
116MP0001529_abnormal_vocalization0.71258532
117MP0000358_abnormal_cell_content/0.71069026
118MP0010678_abnormal_skin_adnexa0.68608371
119MP0002970_abnormal_white_adipose0.68462991
120MP0002160_abnormal_reproductive_system0.67628839
121MP0003656_abnormal_erythrocyte_physiolo0.67574575
122MP0009278_abnormal_bone_marrow0.67181585
123MP0000013_abnormal_adipose_tissue0.66336507
124MP0006138_congestive_heart_failure0.65559414
125MP0000049_abnormal_middle_ear0.65348595
126MP0005666_abnormal_adipose_tissue0.64702237
127MP0000703_abnormal_thymus_morphology0.64611201
128MP0003861_abnormal_nervous_system0.64211002
129MP0003942_abnormal_urinary_system0.63911343
130MP0003115_abnormal_respiratory_system0.62372119
131MP0002114_abnormal_axial_skeleton0.60230671
132MP0002127_abnormal_cardiovascular_syste0.60093668
133MP0001286_abnormal_eye_development0.59284031
134MP0004215_abnormal_myocardial_fiber0.59004762
135MP0004043_abnormal_pH_regulation0.58887220
136MP0003699_abnormal_female_reproductive0.54866922
137MP0003698_abnormal_male_reproductive0.54582388
138MP0008995_early_reproductive_senescence0.54248358
139MP0002132_abnormal_respiratory_system0.54082414
140MP0002722_abnormal_immune_system0.53779307
141MP0002161_abnormal_fertility/fecundity0.53410696
142MP0002089_abnormal_postnatal_growth/wei0.53361956
143MP0003890_abnormal_embryonic-extraembry0.52510546

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.25200296
2Cerebral hypomyelination (HP:0006808)4.55664255
3Breast hypoplasia (HP:0003187)3.94573277
4Rough bone trabeculation (HP:0100670)3.71326349
5Hyperacusis (HP:0010780)3.28601602
6Carpal bone hypoplasia (HP:0001498)3.21301509
7Patellar aplasia (HP:0006443)3.20055367
8Insomnia (HP:0100785)3.15005383
9Aplasia/Hypoplasia of the patella (HP:0006498)3.11797627
10Oral leukoplakia (HP:0002745)3.04575062
11Deep philtrum (HP:0002002)3.02167658
12Entropion (HP:0000621)3.01515775
13Abnormality of the labia minora (HP:0012880)3.00911188
14Selective tooth agenesis (HP:0001592)3.00748543
15Increased nuchal translucency (HP:0010880)2.99538764
16Poikiloderma (HP:0001029)2.99440532
17Impulsivity (HP:0100710)2.94811215
18Congenital stationary night blindness (HP:0007642)2.87894869
19Abnormality of alanine metabolism (HP:0010916)2.82579449
20Hyperalaninemia (HP:0003348)2.82579449
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82579449
22Pelvic girdle muscle weakness (HP:0003749)2.81755964
23Microvesicular hepatic steatosis (HP:0001414)2.81012624
24Colon cancer (HP:0003003)2.79391402
25CNS hypomyelination (HP:0003429)2.78154521
26Ependymoma (HP:0002888)2.76181461
27Shoulder girdle muscle weakness (HP:0003547)2.71188884
28Squamous cell carcinoma (HP:0002860)2.71050939
29Acute myeloid leukemia (HP:0004808)2.69675157
30Abnormal trabecular bone morphology (HP:0100671)2.67971097
31Hypoplasia of the capital femoral epiphysis (HP:0003090)2.66738179
32Cortical dysplasia (HP:0002539)2.66060859
33Aplastic anemia (HP:0001915)2.61828073
34Abnormality of DNA repair (HP:0003254)2.59154102
35Abnormality of the hip-girdle musculature (HP:0001445)2.52989175
36Abnormality of the musculature of the pelvis (HP:0001469)2.52989175
37Reticulocytopenia (HP:0001896)2.52321073
38Abnormality of the calcaneus (HP:0008364)2.50078667
39Abnormality of glycolysis (HP:0004366)2.48050159
40Increased serum pyruvate (HP:0003542)2.48050159
41Progressive external ophthalmoplegia (HP:0000590)2.46871847
42Medulloblastoma (HP:0002885)2.43893720
43Ragged-red muscle fibers (HP:0003200)2.39120519
44Postnatal microcephaly (HP:0005484)2.38077234
45Pendular nystagmus (HP:0012043)2.38015276
46Prominent nose (HP:0000448)2.36278629
47Chromsome breakage (HP:0040012)2.35994602
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.35646842
49Termporal pattern (HP:0011008)2.33442872
50Insidious onset (HP:0003587)2.33442872
51Overriding aorta (HP:0002623)2.33169911
52Microretrognathia (HP:0000308)2.32968028
53Absent radius (HP:0003974)2.31813464
54Neoplasm of the pancreas (HP:0002894)2.31486386
55Ureteral duplication (HP:0000073)2.31363002
56Morphological abnormality of the inner ear (HP:0011390)2.29947806
57Megaloblastic anemia (HP:0001889)2.29846041
58Abnormality of chromosome stability (HP:0003220)2.27720581
59Supernumerary spleens (HP:0009799)2.26544316
60Ankyloglossia (HP:0010296)2.25256070
61Abnormality of the umbilical cord (HP:0010881)2.25033124
62Absent forearm bone (HP:0003953)2.22130272
63Aplasia involving forearm bones (HP:0009822)2.22130272
64Abnormal number of erythroid precursors (HP:0012131)2.20986172
65Abnormality of cochlea (HP:0000375)2.20842127
66Abnormality of the proximal phalanges of the hand (HP:0009834)2.20763536
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19105534
68Pseudobulbar signs (HP:0002200)2.18500398
69Degeneration of anterior horn cells (HP:0002398)2.15728700
70Abnormality of the anterior horn cell (HP:0006802)2.15728700
71Relative macrocephaly (HP:0004482)2.15624814
72Missing ribs (HP:0000921)2.15139202
73Proximal placement of thumb (HP:0009623)2.15012986
74Abnormality of cells of the erythroid lineage (HP:0012130)2.14578673
75Elfin facies (HP:0004428)2.11997230
76Gout (HP:0001997)2.11423538
77Vertebral arch anomaly (HP:0008438)2.10678761
78Abnormality of the preputium (HP:0100587)2.10636957
79Long palpebral fissure (HP:0000637)2.10215960
80Absent epiphyses (HP:0010577)2.09989851
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.09989851
82Duodenal stenosis (HP:0100867)2.09532964
83Small intestinal stenosis (HP:0012848)2.09532964
84Oligodactyly (HP:0012165)2.08280563
85Irregular epiphyses (HP:0010582)2.07796886
86Progressive muscle weakness (HP:0003323)2.07506253
87Overlapping toe (HP:0001845)2.07091187
88Meckel diverticulum (HP:0002245)2.06661711
89Renal duplication (HP:0000075)2.06278673
90Thickened helices (HP:0000391)2.05789080
91Ectopic kidney (HP:0000086)2.04223628
92Abnormal number of incisors (HP:0011064)2.03901918
93Facial hemangioma (HP:0000329)2.03721943
94Cutaneous melanoma (HP:0012056)2.02859180
95Sparse lateral eyebrow (HP:0005338)2.02377060
96Heterotopia (HP:0002282)2.01347937
97Posterior subcapsular cataract (HP:0007787)2.01081875
98Glossoptosis (HP:0000162)2.01003105
99Sandal gap (HP:0001852)2.00464479
100Sloping forehead (HP:0000340)2.00068759
101Deformed tarsal bones (HP:0008119)1.99593958
102Hammertoe (HP:0001765)1.97598438
103Bone marrow hypocellularity (HP:0005528)1.97579077
104Bony spicule pigmentary retinopathy (HP:0007737)1.97466645
105Premature graying of hair (HP:0002216)1.97324735
106Abnormality of the ileum (HP:0001549)1.96745827
107Spinal cord lesions (HP:0100561)1.96617253
108Syringomyelia (HP:0003396)1.96617253
109Horseshoe kidney (HP:0000085)1.96289516
110Pointed chin (HP:0000307)1.95575912
11111 pairs of ribs (HP:0000878)1.94933761
112Calcaneovalgus deformity (HP:0001848)1.94736261
113Hyperglycinemia (HP:0002154)1.94355333
114Atresia of the external auditory canal (HP:0000413)1.93978266
115High anterior hairline (HP:0009890)1.93357869
116Cerebellar dysplasia (HP:0007033)1.91699011
117Dysmetric saccades (HP:0000641)1.91676094
118Flared metaphyses (HP:0003015)1.91108956
119Secondary amenorrhea (HP:0000869)1.90795538
120Deep palmar crease (HP:0006191)1.90488196
121Oligodactyly (hands) (HP:0001180)1.88918833
122Pancreatic fibrosis (HP:0100732)1.88284188
123Long eyelashes (HP:0000527)1.87536128
124Lip pit (HP:0100267)1.84995300
125Abnormal spermatogenesis (HP:0008669)1.84244115
126Rimmed vacuoles (HP:0003805)1.83849926
127Broad distal phalanx of finger (HP:0009836)1.83450669
128Myelodysplasia (HP:0002863)1.82868504
129Pancytopenia (HP:0001876)1.82167144
130Deviation of the thumb (HP:0009603)1.81649156
131Spina bifida occulta (HP:0003298)1.81477368
132Abnormality of the thoracic spine (HP:0100711)1.81264842
133Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.81189862
134Macrocytic anemia (HP:0001972)1.81093124
135Abnormal rod and cone electroretinograms (HP:0008323)1.79949835
136Nephroblastoma (Wilms tumor) (HP:0002667)1.79888883
137Short middle phalanx of the 5th finger (HP:0004220)1.79304915
138Glioma (HP:0009733)1.78842821
139Severe visual impairment (HP:0001141)1.77846292
140Flat cornea (HP:0007720)1.76707856
141Bowel incontinence (HP:0002607)1.75584997
142Neoplasm of the oral cavity (HP:0100649)1.75527353
143Premature ovarian failure (HP:0008209)1.75160329
144Cubitus valgus (HP:0002967)1.75158072
145Duplicated collecting system (HP:0000081)1.75124992
146Abnormal lung lobation (HP:0002101)1.74239868
147Renovascular hypertension (HP:0100817)1.73597145
148Basal cell carcinoma (HP:0002671)1.72720427
149Urethral obstruction (HP:0000796)1.71609445
150Slender long bone (HP:0003100)1.69792915
151Abnormality of the nasal septum (HP:0000419)1.67606873
152Patellar dislocation (HP:0002999)1.66980185
153Elbow flexion contracture (HP:0002987)1.64726666
154Back pain (HP:0003418)1.64456459
155Multiple enchondromatosis (HP:0005701)1.64408220
156Submucous cleft hard palate (HP:0000176)1.62091385
157Asymmetry of the thorax (HP:0001555)1.61363587
158Cafe-au-lait spot (HP:0000957)1.60967010
159Reticulocytosis (HP:0001923)1.60846380
160Abnormal large intestine physiology (HP:0012700)1.60430536
161Obsessive-compulsive behavior (HP:0000722)1.60323101
162Embryonal renal neoplasm (HP:0011794)1.60276856
163Trigonocephaly (HP:0000243)1.58000168
164Cystic hygroma (HP:0000476)1.57497048
165Coarctation of aorta (HP:0001680)1.56865030
166Abnormality of chromosome segregation (HP:0002916)1.56806964
167Radioulnar synostosis (HP:0002974)1.56296844
168Rhabdomyosarcoma (HP:0002859)1.56215755
169Abnormality of reticulocytes (HP:0004312)1.56037606
170Flat acetabular roof (HP:0003180)1.55699694
171Thoracic kyphosis (HP:0002942)1.52870797
172Abnormality of oral frenula (HP:0000190)1.52271144
173Abnormality of the fingertips (HP:0001211)1.50315283
174Disproportionate tall stature (HP:0001519)1.49492201
175Freckling (HP:0001480)1.49292781
176Thin ribs (HP:0000883)1.49262348
177Broad palm (HP:0001169)1.48997172
178Mild short stature (HP:0003502)1.48721335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.52166685
2WEE14.79381443
3TSSK63.57122456
4EIF2AK13.47350726
5CDC73.32946845
6MKNK12.82600732
7SMG12.81443871
8NEK22.65991266
9NEK12.53178493
10SRPK12.52531584
11MKNK22.42203185
12BRSK22.31203539
13STK162.23740690
14ICK2.11915241
15ACVR1B2.10713438
16PRPF4B2.09412703
17TRIB32.07741904
18PLK32.00645821
19PLK41.90494121
20TTK1.89066976
21DYRK31.87641709
22PLK11.81117636
23EIF2AK31.69128850
24CDK71.66417366
25PNCK1.64744401
26MST1R1.64252037
27MAP3K101.60635273
28TESK21.55708652
29ATR1.55225886
30CCNB11.53709238
31LATS11.53614611
32VRK11.46729150
33AKT31.40277699
34KSR21.40026047
35AURKB1.37768449
36BRSK11.37516064
37OXSR11.36372218
38ERN11.33231373
39PDGFRA1.31711764
40CHEK21.31094674
41CDK41.22934950
42RPS6KA41.22383317
43FGFR41.20594925
44LATS21.16260333
45CHEK11.14980107
46STK391.13397647
47BRD41.11180621
48CAMK1G1.05219128
49MET1.03074250
50CAMK1D1.02928365
51MAP3K81.01215689
52NME21.00170312
53CSNK1G30.97830478
54ERBB40.96880770
55AURKA0.92304814
56WNK30.87464208
57PDK30.85945896
58PDK40.85945896
59CSNK1A1L0.85342122
60HIPK20.84210113
61MAP3K130.84017760
62RPS6KB20.81225871
63CDK20.80704942
64STK100.79921817
65CDK80.78025182
66PIM20.76420483
67SCYL20.76268390
68TGFBR10.76071979
69CDK120.72966404
70ATM0.71617339
71MAPK110.70721345
72PAK40.70482589
73PDK20.69937818
74EEF2K0.68946325
75CDK10.68272430
76CSNK1G10.67699479
77ZAK0.65703882
78ALK0.64422571
79EIF2AK20.64104111
80TAF10.63677013
81PAK10.63062579
82NTRK10.62591828
83NEK90.62290160
84FGFR10.62220722
85EPHA20.62160075
86CDK90.61652914
87CDK190.61092422
88PAK20.60663782
89STK30.60266951
90MAPK100.59812615
91CSNK2A20.59012148
92PBK0.58542147
93RAF10.56137437
94CSNK1G20.54485032
95RIPK10.54323384
96CDK30.52431793
97FLT30.52184239
98PRKD30.51057600
99WNK10.49851848
100KSR10.49563652
101SIK10.49394224
102CSNK2A10.48392157
103CSNK1E0.48274590
104STK40.48024490
105AKT20.47675170
106CDK60.45688247
107MAPKAPK50.45396826
108PRKCI0.43173043
109TNIK0.43051965
110RPS6KA10.42032443
111MAP3K140.41875136
112PKN20.41396939
113MTOR0.41167949
114BMX0.40220895
115DMPK0.40036147
116TTN0.39364413
117TIE10.38898955
118RPS6KA50.38756372
119PINK10.37721698
120MELK0.37663801
121PASK0.37474413
122TYRO30.37403702
123RPS6KB10.36973638
124SIK20.35498954
125AKT10.35179844
126UHMK10.35103419
127BRAF0.34546001
128NEK60.34507884
129MAPK10.34368280
130PTK20.34237832
131PRKDC0.32845796
132LRRK20.30965943
133MAPK90.28549892
134TLK10.28011208
135DYRK1A0.27049902
136PIM10.24977961
137WNK40.24323945
138CSNK1D0.22971076
139GSK3B0.22605940
140LMTK20.20690496
141MAPK140.20281420
142BCR0.19655967
143CLK10.19243005

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.54004148
2DNA replication_Homo sapiens_hsa030304.47318334
3RNA polymerase_Homo sapiens_hsa030204.10145068
4Mismatch repair_Homo sapiens_hsa034303.67398775
5Vitamin B6 metabolism_Homo sapiens_hsa007503.55456213
6Spliceosome_Homo sapiens_hsa030403.47607969
7RNA transport_Homo sapiens_hsa030133.41821824
8Cell cycle_Homo sapiens_hsa041103.00672497
9Homologous recombination_Homo sapiens_hsa034402.73842361
10Base excision repair_Homo sapiens_hsa034102.72463641
11Nucleotide excision repair_Homo sapiens_hsa034202.68767603
12Proteasome_Homo sapiens_hsa030502.59914968
13Pyrimidine metabolism_Homo sapiens_hsa002402.49264959
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30218871
15Basal transcription factors_Homo sapiens_hsa030222.02746926
16Ribosome_Homo sapiens_hsa030101.92601519
17Fanconi anemia pathway_Homo sapiens_hsa034601.92224955
18One carbon pool by folate_Homo sapiens_hsa006701.84594145
19RNA degradation_Homo sapiens_hsa030181.83332062
20Non-homologous end-joining_Homo sapiens_hsa034501.79829111
21mRNA surveillance pathway_Homo sapiens_hsa030151.77514978
22Purine metabolism_Homo sapiens_hsa002301.76097958
23Folate biosynthesis_Homo sapiens_hsa007901.65789842
24p53 signaling pathway_Homo sapiens_hsa041151.57183486
25Lysine degradation_Homo sapiens_hsa003101.43183691
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41389355
27Oocyte meiosis_Homo sapiens_hsa041141.31743752
28Pentose phosphate pathway_Homo sapiens_hsa000301.30182375
29Pancreatic cancer_Homo sapiens_hsa052121.27671754
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19377423
31Vitamin digestion and absorption_Homo sapiens_hsa049771.16134747
32Epstein-Barr virus infection_Homo sapiens_hsa051691.13405605
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11616091
34Acute myeloid leukemia_Homo sapiens_hsa052211.10665122
35Non-small cell lung cancer_Homo sapiens_hsa052231.09332475
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09210000
37Endometrial cancer_Homo sapiens_hsa052131.08241242
38Pyruvate metabolism_Homo sapiens_hsa006201.04790631
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02684876
40* Biosynthesis of amino acids_Homo sapiens_hsa012300.96771041
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96086707
42Arginine biosynthesis_Homo sapiens_hsa002200.93193599
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92676608
44* Cysteine and methionine metabolism_Homo sapiens_hsa002700.90144204
45Phototransduction_Homo sapiens_hsa047440.85378392
46ErbB signaling pathway_Homo sapiens_hsa040120.84406959
47Steroid biosynthesis_Homo sapiens_hsa001000.81203207
48Sulfur relay system_Homo sapiens_hsa041220.79977152
49Glioma_Homo sapiens_hsa052140.76629179
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76365553
51Adherens junction_Homo sapiens_hsa045200.76186973
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75582147
53Herpes simplex infection_Homo sapiens_hsa051680.74410369
54Insulin signaling pathway_Homo sapiens_hsa049100.73549485
55Viral carcinogenesis_Homo sapiens_hsa052030.73173223
56Small cell lung cancer_Homo sapiens_hsa052220.70828049
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70770059
58Fatty acid metabolism_Homo sapiens_hsa012120.70293628
59Fatty acid biosynthesis_Homo sapiens_hsa000610.69870266
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68534845
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.65463052
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65402010
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64962036
64Regulation of autophagy_Homo sapiens_hsa041400.64924435
65Antigen processing and presentation_Homo sapiens_hsa046120.63127627
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62163852
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.61443439
68Carbon metabolism_Homo sapiens_hsa012000.61309700
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60973890
70HTLV-I infection_Homo sapiens_hsa051660.57933066
71Glucagon signaling pathway_Homo sapiens_hsa049220.55124611
72Prolactin signaling pathway_Homo sapiens_hsa049170.53499893
73Thyroid hormone synthesis_Homo sapiens_hsa049180.52763386
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.49812567
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47385852
76Fructose and mannose metabolism_Homo sapiens_hsa000510.46815995
77VEGF signaling pathway_Homo sapiens_hsa043700.46542117
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46050249
79Thyroid cancer_Homo sapiens_hsa052160.45365737
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45190160
81Prion diseases_Homo sapiens_hsa050200.41554807
82Selenocompound metabolism_Homo sapiens_hsa004500.41490777
83Hippo signaling pathway_Homo sapiens_hsa043900.41445232
84MicroRNAs in cancer_Homo sapiens_hsa052060.41422607
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.40857052
86Proteoglycans in cancer_Homo sapiens_hsa052050.40526085
87Melanoma_Homo sapiens_hsa052180.40383592
88Renin-angiotensin system_Homo sapiens_hsa046140.40187313
89Systemic lupus erythematosus_Homo sapiens_hsa053220.39551530
90Circadian rhythm_Homo sapiens_hsa047100.39476926
91Hepatitis C_Homo sapiens_hsa051600.38440613
92Choline metabolism in cancer_Homo sapiens_hsa052310.37813844
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.37595830
94Hedgehog signaling pathway_Homo sapiens_hsa043400.37103111
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36872927
96Glutathione metabolism_Homo sapiens_hsa004800.34394762
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33917099
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32946650
99N-Glycan biosynthesis_Homo sapiens_hsa005100.31972561
100TGF-beta signaling pathway_Homo sapiens_hsa043500.31382168
101Colorectal cancer_Homo sapiens_hsa052100.31000181
102HIF-1 signaling pathway_Homo sapiens_hsa040660.30914184
103Arginine and proline metabolism_Homo sapiens_hsa003300.29546958
104* Metabolic pathways_Homo sapiens_hsa011000.26630686
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25302699
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.23419566
107Pathways in cancer_Homo sapiens_hsa052000.22817864
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20437232
109mTOR signaling pathway_Homo sapiens_hsa041500.20227441
110Alcoholism_Homo sapiens_hsa050340.19979080
111Hepatitis B_Homo sapiens_hsa051610.18121824
112Basal cell carcinoma_Homo sapiens_hsa052170.16776415
113Prostate cancer_Homo sapiens_hsa052150.16768390
114Notch signaling pathway_Homo sapiens_hsa043300.16725428
115Mineral absorption_Homo sapiens_hsa049780.16712947
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16320221
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14457221
118Bladder cancer_Homo sapiens_hsa052190.13897084
119Tight junction_Homo sapiens_hsa045300.13631335
120Renal cell carcinoma_Homo sapiens_hsa052110.13202367
121Chronic myeloid leukemia_Homo sapiens_hsa052200.13014595
122Apoptosis_Homo sapiens_hsa042100.12436757
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12393707
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11085150
125FoxO signaling pathway_Homo sapiens_hsa040680.09840506
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08190049
127Sphingolipid metabolism_Homo sapiens_hsa006000.07172815
128Wnt signaling pathway_Homo sapiens_hsa043100.06667446
129Shigellosis_Homo sapiens_hsa051310.04991043
130Inositol phosphate metabolism_Homo sapiens_hsa005620.04145927
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01652269
132AMPK signaling pathway_Homo sapiens_hsa041520.01110504
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.01043917
134Protein digestion and absorption_Homo sapiens_hsa04974-0.0009391

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