MAT2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.15169503
2negative regulation of cell killing (GO:0031342)6.15169503
3regulation of female gonad development (GO:2000194)5.86457551
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.61271166
5positive regulation of gamma-delta T cell activation (GO:0046645)5.54723462
6cellular response to interleukin-15 (GO:0071350)5.26879700
7negative T cell selection (GO:0043383)5.11326771
8response to interleukin-15 (GO:0070672)4.99984953
9negative thymic T cell selection (GO:0045060)4.97555689
10mitotic metaphase plate congression (GO:0007080)4.91985371
11regulation of B cell receptor signaling pathway (GO:0050855)4.90386454
12attachment of spindle microtubules to kinetochore (GO:0008608)4.85259038
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80470855
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77462316
15antigen processing and presentation of endogenous antigen (GO:0019883)4.75603819
16regulation of meiosis (GO:0040020)4.73440662
17maturation of 5.8S rRNA (GO:0000460)4.60963153
18female gamete generation (GO:0007292)4.55812017
19regulation of histone H3-K27 methylation (GO:0061085)4.52845742
20piRNA metabolic process (GO:0034587)4.38630200
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29929881
22chaperone-mediated protein transport (GO:0072321)4.21700958
23regulation of regulatory T cell differentiation (GO:0045589)4.12974238
24positive thymic T cell selection (GO:0045059)4.09015392
25CENP-A containing nucleosome assembly (GO:0034080)4.07545346
26metaphase plate congression (GO:0051310)4.07450291
27regulation of gamma-delta T cell differentiation (GO:0045586)4.06568676
28negative regulation of meiosis (GO:0045835)3.99999024
29meiotic cell cycle (GO:0051321)3.97561465
30regulation of meiosis I (GO:0060631)3.88063394
31regulation of gamma-delta T cell activation (GO:0046643)3.87461461
32protein K6-linked ubiquitination (GO:0085020)3.86490765
33chromatin remodeling at centromere (GO:0031055)3.85527090
34positive T cell selection (GO:0043368)3.84066101
35presynaptic membrane assembly (GO:0097105)3.82143423
36regulation of meiotic cell cycle (GO:0051445)3.82076083
37cytidine metabolic process (GO:0046087)3.79652296
38cytidine catabolic process (GO:0006216)3.79652296
39cytidine deamination (GO:0009972)3.79652296
40establishment of chromosome localization (GO:0051303)3.78490289
41protein deneddylation (GO:0000338)3.77888052
42negative regulation of meiotic cell cycle (GO:0051447)3.74165911
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.72972889
44regulation of alpha-beta T cell proliferation (GO:0046640)3.71523045
45T cell migration (GO:0072678)3.71507951
46regulation of natural killer cell mediated immunity (GO:0002715)3.68704300
47regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.68704300
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.68547199
49negative regulation of T cell mediated immunity (GO:0002710)3.67286509
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.64112802
51regulation of DNA methylation (GO:0044030)3.60722334
52oocyte maturation (GO:0001556)3.59225165
53regulation of T cell mediated cytotoxicity (GO:0001914)3.55596396
54positive regulation of B cell differentiation (GO:0045579)3.53654117
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52206871
56thymic T cell selection (GO:0045061)3.48671070
57positive regulation of natural killer cell mediated immunity (GO:0002717)3.48166996
58immunoglobulin mediated immune response (GO:0016064)3.47415429
59regulation of leukocyte mediated cytotoxicity (GO:0001910)3.46933916
60positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.46922332
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.46113492
62regulation of B cell differentiation (GO:0045577)3.45429632
63regulation of T cell tolerance induction (GO:0002664)3.45210733
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.45068721
65positive regulation of tolerance induction (GO:0002645)3.44974523
66pyrimidine ribonucleoside catabolic process (GO:0046133)3.43921910
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.42657599
68T cell selection (GO:0045058)3.41916909
69positive regulation of T cell mediated cytotoxicity (GO:0001916)3.41247602
70activated T cell proliferation (GO:0050798)3.40196008
71DNA methylation involved in gamete generation (GO:0043046)3.37465579
72negative regulation of hormone metabolic process (GO:0032351)3.37362347
73negative regulation of hormone biosynthetic process (GO:0032353)3.37362347
74B cell mediated immunity (GO:0019724)3.36321698
75mitotic chromosome condensation (GO:0007076)3.35552170
76tolerance induction (GO:0002507)3.31859963
77mitotic sister chromatid segregation (GO:0000070)3.31416166
78presynaptic membrane organization (GO:0097090)3.28623653
79postsynaptic membrane organization (GO:0001941)3.27557266
80DNA replication-independent nucleosome organization (GO:0034724)3.25854354
81DNA replication-independent nucleosome assembly (GO:0006336)3.25854354
82regulation of tolerance induction (GO:0002643)3.24624161
83negative regulation of leukocyte mediated immunity (GO:0002704)3.22763387
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.22550228
85positive regulation of megakaryocyte differentiation (GO:0045654)3.22360871
86dendritic cell chemotaxis (GO:0002407)3.21974529
87positive regulation of mitochondrial fission (GO:0090141)3.20862259
88histone exchange (GO:0043486)3.19974252
89negative regulation of T cell apoptotic process (GO:0070233)3.18989612
90response to interferon-beta (GO:0035456)3.18612082
91regulation of cell killing (GO:0031341)3.18502711
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16759580
93positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.15397159
94microtubule severing (GO:0051013)3.15312442
95positive regulation of cell killing (GO:0031343)3.15120533
96leukocyte aggregation (GO:0070486)3.14411537
97DNA replication checkpoint (GO:0000076)3.12533213
98cellular response to type I interferon (GO:0071357)3.11686840
99type I interferon signaling pathway (GO:0060337)3.11686840
100base-excision repair, AP site formation (GO:0006285)3.10204571
101regulation of RIG-I signaling pathway (GO:0039535)3.05659038
102response to type I interferon (GO:0034340)3.04304933
103mast cell activation (GO:0045576)3.02193438
104regulation of isotype switching to IgG isotypes (GO:0048302)3.02168510
105neuron cell-cell adhesion (GO:0007158)3.02069099
106neutrophil activation involved in immune response (GO:0002283)3.01197944
107snRNA transcription (GO:0009301)3.01059060
108kinetochore assembly (GO:0051382)3.00029974
1097-methylguanosine mRNA capping (GO:0006370)2.99402569
110regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.97311008
111respiratory chain complex IV assembly (GO:0008535)2.97145447
112meiotic chromosome segregation (GO:0045132)2.96387349
113negative regulation of DNA-templated transcription, elongation (GO:0032785)2.95671835
114negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.95671835
115positive regulation of granulocyte differentiation (GO:0030854)2.95561628
116regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94857777
117T cell receptor signaling pathway (GO:0050852)2.93933680
118regulation of exit from mitosis (GO:0007096)2.93571927
119negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.92065002
120dendritic cell migration (GO:0036336)2.92019403
121positive regulation of T cell mediated immunity (GO:0002711)2.91987162
122RNA capping (GO:0036260)2.91884770
1237-methylguanosine RNA capping (GO:0009452)2.91884770
124modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91823809
125positive regulation by organism of defense response of other organism involved in symbiotic interact2.91823809
126modulation by symbiont of host immune response (GO:0052553)2.91823809
127positive regulation by symbiont of host defense response (GO:0052509)2.91823809
128modulation by symbiont of host defense response (GO:0052031)2.91823809
129modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91823809
130antigen processing and presentation via MHC class Ib (GO:0002475)2.91807086
131antigen receptor-mediated signaling pathway (GO:0050851)2.91615261
132positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.91481424
133negative regulation of viral genome replication (GO:0045071)2.91248057
134neutrophil activation (GO:0042119)2.89257694
135actin nucleation (GO:0045010)2.87882691
136spindle checkpoint (GO:0031577)2.87369623
137negative regulation of adaptive immune response (GO:0002820)2.87164372
138negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86590022
139male meiosis (GO:0007140)2.85775898
140proteasome assembly (GO:0043248)2.84718938
141B cell receptor signaling pathway (GO:0050853)2.84262201
142positive regulation of T cell differentiation in thymus (GO:0033089)2.84116656
143neurotransmitter-gated ion channel clustering (GO:0072578)2.82823751
144regulation of T cell mediated immunity (GO:0002709)2.82438701
145pyrimidine nucleotide catabolic process (GO:0006244)2.79602086
146interferon-gamma-mediated signaling pathway (GO:0060333)2.78177800
147kinetochore organization (GO:0051383)2.77682284
148protein localization to kinetochore (GO:0034501)2.77167642
149DNA replication initiation (GO:0006270)2.76698755
150regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76580134
151righting reflex (GO:0060013)2.76343837
152negative regulation of interleukin-12 production (GO:0032695)2.75839828
153negative regulation of execution phase of apoptosis (GO:1900118)2.74758893
154positive regulation of natural killer cell differentiation (GO:0032825)2.74728529
155protein K11-linked ubiquitination (GO:0070979)2.74581446
156positive regulation of neurotransmitter secretion (GO:0001956)2.74422092
157regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.74323026
158protein localization to chromosome, centromeric region (GO:0071459)2.74040196
159positive regulation of T cell cytokine production (GO:0002726)2.73014207
160regulation of double-strand break repair via homologous recombination (GO:0010569)2.72953685
161regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72264857
162regulation of mitotic spindle checkpoint (GO:1903504)2.71728088
163regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.71728088
164positive regulation of meiosis (GO:0045836)2.71595117
165interferon-gamma production (GO:0032609)2.71234400
166chromosome segregation (GO:0007059)2.71185156
167negative regulation of T-helper cell differentiation (GO:0045623)2.70811142
168negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.70811142
169histone H2A ubiquitination (GO:0033522)2.69326137
170regulation of T cell receptor signaling pathway (GO:0050856)2.68802725
171protein K48-linked ubiquitination (GO:0070936)2.68119690
172exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67880416
173pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67838363
174negative regulation of innate immune response (GO:0045824)2.66662476
175positive regulation of lymphocyte mediated immunity (GO:0002708)2.66078237
176neuronal action potential propagation (GO:0019227)2.64951985
177regulation of spindle organization (GO:0090224)2.64948223
178negative regulation of nuclear division (GO:0051784)2.64947427
179mitotic spindle checkpoint (GO:0071174)2.64916382
180positive regulation of meiotic cell cycle (GO:0051446)2.64649194
181granulocyte activation (GO:0036230)2.63348226
182rRNA methylation (GO:0031167)2.60911406
183cytochrome complex assembly (GO:0017004)2.60687149
184T cell costimulation (GO:0031295)2.60619031
185regulation of acyl-CoA biosynthetic process (GO:0050812)2.60507600
186regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.60418146
187regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.60418146
188regulation of interleukin-2 biosynthetic process (GO:0045076)2.60336913
189rRNA modification (GO:0000154)2.58732971
190nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58658311
191mitochondrial respiratory chain complex I assembly (GO:0032981)2.57524905
192NADH dehydrogenase complex assembly (GO:0010257)2.57524905
193mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57524905
194cullin deneddylation (GO:0010388)2.57274387
195DNA deamination (GO:0045006)2.56054681
196negative regulation of sister chromatid segregation (GO:0033046)2.55055235
197negative regulation of mitotic sister chromatid separation (GO:2000816)2.55055235
198negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55055235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.20579584
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.18632830
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.20637008
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.10506806
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.91366690
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.88564971
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.74055915
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.53376203
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.30313578
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.21634478
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18732362
12MYB_26560356_Chip-Seq_TH2_Human2.98018506
13GBX2_23144817_ChIP-Seq_PC3_Human2.87435825
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86713596
15RUNX_20019798_ChIP-Seq_JUKART_Human2.76026870
16E2F7_22180533_ChIP-Seq_HELA_Human2.74465531
17EZH2_22144423_ChIP-Seq_EOC_Human2.67243155
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64615335
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62277035
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62129315
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.58389990
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.56754645
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52604982
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51213016
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49946417
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.39679946
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31095925
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30913478
29SPI1_23547873_ChIP-Seq_NB4_Human2.29650696
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24145516
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22370900
32VDR_22108803_ChIP-Seq_LS180_Human2.22247873
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.17278446
34MYB_26560356_Chip-Seq_TH1_Human2.15021003
35PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12444929
36* IRF8_27001747_Chip-Seq_BMDM_Mouse2.10347950
37* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.09831269
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09271516
39* FUS_26573619_Chip-Seq_HEK293_Human2.08688375
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08128537
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03168190
42GATA3_27048872_Chip-Seq_THYMUS_Human2.02763454
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01632046
44* TAF15_26573619_Chip-Seq_HEK293_Human1.93098944
45GATA3_26560356_Chip-Seq_TH2_Human1.91183999
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88186868
47MYC_18940864_ChIP-ChIP_HL60_Human1.79029642
48* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74510588
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71176320
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68640439
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67210296
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65843225
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.61657272
54VDR_23849224_ChIP-Seq_CD4+_Human1.60469849
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59489478
56MAF_26560356_Chip-Seq_TH1_Human1.57000162
57IRF1_19129219_ChIP-ChIP_H3396_Human1.56340934
58* EWS_26573619_Chip-Seq_HEK293_Human1.55299613
59* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54805409
60* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.54139282
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54091294
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52766104
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51899257
64LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50037284
65* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.49495264
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49233969
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46028322
68* SRF_21415370_ChIP-Seq_HL-1_Mouse1.44905491
69AR_21909140_ChIP-Seq_LNCAP_Human1.44686310
70* RNF2_27304074_Chip-Seq_NSC_Mouse1.44214690
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43889290
72CIITA_25753668_ChIP-Seq_RAJI_Human1.43406254
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42563153
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41543900
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.41066714
76GATA1_22025678_ChIP-Seq_K562_Human1.39635449
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37950690
78* UTX_26944678_Chip-Seq_JUKART_Human1.37217994
79SCL_19346495_ChIP-Seq_HPC-7_Human1.37031863
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36360455
81P300_19829295_ChIP-Seq_ESCs_Human1.35738268
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34533117
83* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29344104
84IGF1R_20145208_ChIP-Seq_DFB_Human1.29163610
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28006246
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.27083986
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24620386
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.24595094
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23870901
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22616306
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22311439
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22273413
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.21998150
94DCP1A_22483619_ChIP-Seq_HELA_Human1.19318296
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.19065077
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18500469
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.18219128
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18162165
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.18023253
100THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17660036
101MYC_18555785_ChIP-Seq_MESCs_Mouse1.17603127
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.16735304
103FOXP3_21729870_ChIP-Seq_TREG_Human1.16632283
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16477358
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16313202
106CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16094834
107P53_22387025_ChIP-Seq_ESCs_Mouse1.15213266
108RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14026897
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.13620930
110GATA1_26923725_Chip-Seq_HPCs_Mouse1.12702491
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10133850
112* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09228460
113* GABP_19822575_ChIP-Seq_HepG2_Human1.09062409
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08944343
115* SMAD4_21799915_ChIP-Seq_A2780_Human1.07225135
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07200469
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06536677
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06200079
119MAF_26560356_Chip-Seq_TH2_Human1.06153533
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.05892290
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05519472
122KLF4_18555785_Chip-Seq_ESCs_Mouse1.05032109
123CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04134641
124CTCF_18555785_Chip-Seq_ESCs_Mouse1.03928082
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03049916
126PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02147258
127JUN_21703547_ChIP-Seq_K562_Human1.01425044
128P300_18555785_Chip-Seq_ESCs_Mouse1.01227131
129* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01226184
130E2F1_21310950_ChIP-Seq_MCF-7_Human1.00564298
131ELK1_19687146_ChIP-ChIP_HELA_Human1.00043783
132AR_21572438_ChIP-Seq_LNCaP_Human0.99898539
133* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98121963
134GATA3_26560356_Chip-Seq_TH1_Human0.97790924
135ZFX_18555785_Chip-Seq_ESCs_Mouse0.97106472
136GATA3_21867929_ChIP-Seq_TH1_Mouse0.96439487
137E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96284161
138OCT4_18555785_Chip-Seq_ESCs_Mouse0.95836591
139SPI1_23127762_ChIP-Seq_K562_Human0.95256362
140FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95187218
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95079505
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.94403497
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94045412
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93683058
145KDM2B_26808549_Chip-Seq_REH_Human0.93375956
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93271413
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92804771
148YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91445772
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.91198912
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90792764
151AR_25329375_ChIP-Seq_VCAP_Human0.90703971
152NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90565798
153FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89690510
154PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86543485
155EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84957415
156CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83822668
157* PU_27001747_Chip-Seq_BMDM_Mouse0.83813821
158GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82830518
159TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81247386
160CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81117693
161PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79073380
162GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77078240
163EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76280058
164VDR_24787735_ChIP-Seq_THP-1_Human0.75546757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.72222929
2MP0001835_abnormal_antigen_presentation4.25174589
3MP0003724_increased_susceptibility_to4.08779227
4MP0003718_maternal_effect4.07961248
5MP0005451_abnormal_body_composition3.56173804
6MP0003646_muscle_fatigue3.41131188
7MP0002102_abnormal_ear_morphology3.28492102
8MP0001800_abnormal_humoral_immune3.22224485
9MP0009785_altered_susceptibility_to3.10772980
10MP0000685_abnormal_immune_system3.09936801
11MP0005000_abnormal_immune_tolerance3.06068266
12MP0006292_abnormal_olfactory_placode2.94527224
13MP0003693_abnormal_embryo_hatching2.94150759
14MP0003436_decreased_susceptibility_to2.93892379
15MP0008877_abnormal_DNA_methylation2.88801380
16MP0001790_abnormal_immune_system2.80548320
17MP0005387_immune_system_phenotype2.80548320
18MP0010094_abnormal_chromosome_stability2.80160271
19MP0002723_abnormal_immune_serum2.77978389
20MP0002420_abnormal_adaptive_immunity2.71459475
21MP0001819_abnormal_immune_cell2.67786904
22MP0002148_abnormal_hypersensitivity_rea2.63143436
23MP0002452_abnormal_antigen_presenting2.60574232
24MP0005025_abnormal_response_to2.59250838
25MP0006082_CNS_inflammation2.47995370
26MP0002166_altered_tumor_susceptibility2.32532182
27MP0001968_abnormal_touch/_nociception2.31851077
28MP0002419_abnormal_innate_immunity2.25953891
29MP0001905_abnormal_dopamine_level2.24141956
30MP0002736_abnormal_nociception_after2.21861129
31MP0010155_abnormal_intestine_physiology2.17715119
32MP0000716_abnormal_immune_system2.17042527
33MP0002405_respiratory_system_inflammati2.11454371
34MP0003136_yellow_coat_color2.10735443
35MP0000689_abnormal_spleen_morphology2.10147131
36MP0001529_abnormal_vocalization2.10087564
37MP0004859_abnormal_synaptic_plasticity2.09090209
38MP0000703_abnormal_thymus_morphology2.04665339
39MP0004957_abnormal_blastocyst_morpholog2.03417990
40MP0002722_abnormal_immune_system2.00720535
41MP0003787_abnormal_imprinting1.99857695
42MP0002653_abnormal_ependyma_morphology1.98281675
43MP0001119_abnormal_female_reproductive1.93872926
44MP0004270_analgesia1.91068930
45MP0003077_abnormal_cell_cycle1.90305752
46MP0005075_abnormal_melanosome_morpholog1.89646601
47MP0003866_abnormal_defecation1.89145768
48MP0000465_gastrointestinal_hemorrhage1.88066970
49MP0001188_hyperpigmentation1.86999433
50MP0002006_tumorigenesis1.86964957
51MP0005646_abnormal_pituitary_gland1.82808333
52MP0003879_abnormal_hair_cell1.82593370
53MP0008260_abnormal_autophagy1.81376177
54MP0003763_abnormal_thymus_physiology1.78127267
55MP0002429_abnormal_blood_cell1.76126310
56MP0001845_abnormal_inflammatory_respons1.75946797
57MP0003111_abnormal_nucleus_morphology1.69806369
58MP0005464_abnormal_platelet_physiology1.67701275
59MP0004947_skin_inflammation1.67545262
60MP0001873_stomach_inflammation1.63828282
61MP0001533_abnormal_skeleton_physiology1.60676586
62MP0004145_abnormal_muscle_electrophysio1.59479836
63MP0003635_abnormal_synaptic_transmissio1.57117259
64MP0003699_abnormal_female_reproductive1.56607113
65MP0010386_abnormal_urinary_bladder1.53992143
66MP0003303_peritoneal_inflammation1.52754514
67MP0002734_abnormal_mechanical_nocicepti1.51687006
68MP0005395_other_phenotype1.50247247
69MP0009764_decreased_sensitivity_to1.49758994
70MP0001929_abnormal_gametogenesis1.48632486
71MP0002396_abnormal_hematopoietic_system1.48122679
72MP0000653_abnormal_sex_gland1.46388417
73MP0008007_abnormal_cellular_replicative1.43824703
74MP0002210_abnormal_sex_determination1.42364169
75MP0008058_abnormal_DNA_repair1.41660347
76MP0001853_heart_inflammation1.40138760
77MP0009745_abnormal_behavioral_response1.38756402
78MP0002277_abnormal_respiratory_mucosa1.36711369
79MP0003123_paternal_imprinting1.34007585
80MP0008469_abnormal_protein_level1.33113321
81MP0005310_abnormal_salivary_gland1.32221452
82MP0002138_abnormal_hepatobiliary_system1.28323734
83MP0002572_abnormal_emotion/affect_behav1.27692760
84MP0006276_abnormal_autonomic_nervous1.26535263
85MP0001485_abnormal_pinna_reflex1.25966931
86MP0008004_abnormal_stomach_pH1.24986423
87MP0004215_abnormal_myocardial_fiber1.21315964
88MP0002063_abnormal_learning/memory/cond1.18647898
89MP0003806_abnormal_nucleotide_metabolis1.16765373
90MP0002009_preneoplasia1.15847804
91MP0002272_abnormal_nervous_system1.10724435
92MP0008932_abnormal_embryonic_tissue1.10391816
93MP0004484_altered_response_of1.10205994
94MP0001984_abnormal_olfaction1.08631971
95MP0002067_abnormal_sensory_capabilities1.08616565
96MP0000490_abnormal_crypts_of1.07987225
97MP0001919_abnormal_reproductive_system1.07489509
98MP0002132_abnormal_respiratory_system1.06584883
99MP0003315_abnormal_perineum_morphology1.05959126
100MP0009763_increased_sensitivity_to1.05638583
101MP0003448_altered_tumor_morphology1.05047975
102MP0000015_abnormal_ear_pigmentation1.04505812
103MP0002837_dystrophic_cardiac_calcinosis1.03978433
104MP0002160_abnormal_reproductive_system1.02815422
105MP0003300_gastrointestinal_ulcer1.02476237
106MP0005671_abnormal_response_to1.02380318
107MP0002638_abnormal_pupillary_reflex1.01027346
108MP0005389_reproductive_system_phenotype0.99845403
109MP0000858_altered_metastatic_potential0.98851699
110MP0002249_abnormal_larynx_morphology0.98420394
111MP0005408_hypopigmentation0.98123337
112MP0002933_joint_inflammation0.94801208
113MP0002161_abnormal_fertility/fecundity0.93950374
114MP0001145_abnormal_male_reproductive0.93665554
115MP0002064_seizures0.93196199
116MP0003828_pulmonary_edema0.92978586
117MP0001486_abnormal_startle_reflex0.92498238
118MP0009765_abnormal_xenobiotic_induced0.91382399
119MP0001970_abnormal_pain_threshold0.91289581
120MP0000566_synostosis0.88736785
121MP0001851_eye_inflammation0.88605434
122MP0001502_abnormal_circadian_rhythm0.88239595
123MP0004510_myositis0.88177381
124MP0003121_genomic_imprinting0.87813167
125MP0002876_abnormal_thyroid_physiology0.87667692
126MP0009333_abnormal_splenocyte_physiolog0.86906972
127MP0000372_irregular_coat_pigmentation0.86283903
128MP0004924_abnormal_behavior0.86096938
129MP0005386_behavior/neurological_phenoty0.86096938
130MP0003191_abnormal_cellular_cholesterol0.85616417
131MP0000631_abnormal_neuroendocrine_gland0.85602873
132MP0003656_abnormal_erythrocyte_physiolo0.83763353
133MP0001963_abnormal_hearing_physiology0.82385107
134MP0005166_decreased_susceptibility_to0.81317411
135MP0008057_abnormal_DNA_replication0.79856445
136MP0006036_abnormal_mitochondrial_physio0.79836022
137MP0003183_abnormal_peptide_metabolism0.79368933
138MP0003786_premature_aging0.79089475
139MP0001501_abnormal_sleep_pattern0.78826326
140MP0002163_abnormal_gland_morphology0.77890836
141MP0009046_muscle_twitch0.76747882
142MP0002019_abnormal_tumor_incidence0.76103548
143MP0003252_abnormal_bile_duct0.75500037
144MP0004147_increased_porphyrin_level0.75143424
145MP0002735_abnormal_chemical_nociception0.73912072
146MP0009697_abnormal_copulation0.72040353
147MP0005409_darkened_coat_color0.71272658
148MP0004381_abnormal_hair_follicle0.70672517
149MP0001986_abnormal_taste_sensitivity0.70667789
150MP0005084_abnormal_gallbladder_morpholo0.70312149
151MP0000639_abnormal_adrenal_gland0.69467365
152MP0002398_abnormal_bone_marrow0.69002254
153MP0000026_abnormal_inner_ear0.67804268
154MP0004883_abnormal_blood_vessel0.67447793
155MP0005379_endocrine/exocrine_gland_phen0.66125480
156MP0002095_abnormal_skin_pigmentation0.65310142
157MP0006054_spinal_hemorrhage0.64909599
158MP0006035_abnormal_mitochondrial_morpho0.64558759
159MP0002557_abnormal_social/conspecific_i0.64117893
160MP0006072_abnormal_retinal_apoptosis0.63999478
161MP0002177_abnormal_outer_ear0.63189727
162MP0008873_increased_physiological_sensi0.59721205
163MP0001663_abnormal_digestive_system0.58278687
164MP0005397_hematopoietic_system_phenotyp0.55761364
165MP0001545_abnormal_hematopoietic_system0.55761364
166MP0005390_skeleton_phenotype0.55530041
167MP0003075_altered_response_to0.55149708
168MP0003221_abnormal_cardiomyocyte_apopto0.54756881
169MP0000313_abnormal_cell_death0.54604136
170MP0002998_abnormal_bone_remodeling0.54531760
171MP0000569_abnormal_digit_pigmentation0.53491218
172MP0005085_abnormal_gallbladder_physiolo0.50966542
173MP0001764_abnormal_homeostasis0.50862435
174MP0003045_fibrosis0.50642928

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.02857482
2Abnormality of T cell number (HP:0011839)5.69986490
3Severe combined immunodeficiency (HP:0004430)4.88154730
4IgG deficiency (HP:0004315)4.82564235
5Birth length less than 3rd percentile (HP:0003561)4.45215492
6Abnormality of T cells (HP:0002843)4.43976358
7Panhypogammaglobulinemia (HP:0003139)4.40760493
8Focal motor seizures (HP:0011153)4.30843802
9Combined immunodeficiency (HP:0005387)4.23683633
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.13303533
11Stomatitis (HP:0010280)4.08749467
12Elevated erythrocyte sedimentation rate (HP:0003565)3.98151533
13Myositis (HP:0100614)3.95882692
14Male infertility (HP:0003251)3.95484874
15Increased IgM level (HP:0003496)3.95361770
16B lymphocytopenia (HP:0010976)3.95190781
17Encephalitis (HP:0002383)3.93909147
18Abnormality of B cell number (HP:0010975)3.89665239
19Recurrent cutaneous fungal infections (HP:0011370)3.88509849
20Chronic mucocutaneous candidiasis (HP:0002728)3.88509849
21Recurrent fungal infections (HP:0002841)3.83728567
22Thyroiditis (HP:0100646)3.75140556
23Breast hypoplasia (HP:0003187)3.72278301
24Recurrent abscess formation (HP:0002722)3.68255193
25Abnormality of eosinophils (HP:0001879)3.67056592
26Eczematoid dermatitis (HP:0000976)3.65216302
27Recurrent bacterial skin infections (HP:0005406)3.64131349
28Autoimmune hemolytic anemia (HP:0001890)3.63829168
29Chronic diarrhea (HP:0002028)3.52903933
30Recurrent bronchitis (HP:0002837)3.51665067
31Agammaglobulinemia (HP:0004432)3.51150508
32Meningitis (HP:0001287)3.44990334
33Recurrent viral infections (HP:0004429)3.41397881
34IgM deficiency (HP:0002850)3.36525089
35Orchitis (HP:0100796)3.34324341
36Atonic seizures (HP:0010819)3.32980937
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.32285130
38Abnormality of alanine metabolism (HP:0010916)3.32285130
39Hyperalaninemia (HP:0003348)3.32285130
40Eosinophilia (HP:0001880)3.25769185
41Abnormality of T cell physiology (HP:0011840)3.24419405
42Leukocytosis (HP:0001974)3.19337406
43Recurrent skin infections (HP:0001581)3.12226574
44Granulocytopenia (HP:0001913)2.99094076
45Nonprogressive disorder (HP:0003680)2.98810404
46Chromsome breakage (HP:0040012)2.98142279
47Type 2 muscle fiber atrophy (HP:0003554)2.94962096
48Keratoconjunctivitis sicca (HP:0001097)2.92764056
49Hepatocellular necrosis (HP:0001404)2.92255054
50Epileptic encephalopathy (HP:0200134)2.88744342
51Keratoconjunctivitis (HP:0001096)2.86815617
52Abnormality of the prostate (HP:0008775)2.86324982
53Hypoproteinemia (HP:0003075)2.83454720
54Mediastinal lymphadenopathy (HP:0100721)2.83083405
55Pustule (HP:0200039)2.81993137
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80975848
57Acute necrotizing encephalopathy (HP:0006965)2.79285147
58Vasculitis (HP:0002633)2.79023970
59Abnormality of macrophages (HP:0004311)2.78833787
60Premature ovarian failure (HP:0008209)2.78677713
61Supernumerary spleens (HP:0009799)2.77619112
62Patellar aplasia (HP:0006443)2.75327059
63Pulmonary fibrosis (HP:0002206)2.71826814
64Pancreatic fibrosis (HP:0100732)2.70758576
65Abnormal mitochondria in muscle tissue (HP:0008316)2.70057220
66Febrile seizures (HP:0002373)2.68739153
67Pulmonary infiltrates (HP:0002113)2.67351943
68Gastrointestinal infarctions (HP:0005244)2.65929979
69Abnormality of the labia minora (HP:0012880)2.62489256
70Increased hepatocellular lipid droplets (HP:0006565)2.61401973
71Mitochondrial inheritance (HP:0001427)2.60759789
72Abnormality of the preputium (HP:0100587)2.58369700
73Aplasia/Hypoplasia of the patella (HP:0006498)2.55997602
74Muscle fiber atrophy (HP:0100295)2.54701966
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54224745
76Inflammation of the large intestine (HP:0002037)2.54176440
77Lymphopenia (HP:0001888)2.53452083
78Chronic otitis media (HP:0000389)2.52116152
79Capillary hemangiomas (HP:0005306)2.51245359
80Hypoplasia of the thymus (HP:0000778)2.50650873
81Increased CSF lactate (HP:0002490)2.49783887
82Lymphoma (HP:0002665)2.46213667
83Respiratory difficulties (HP:0002880)2.46162374
84Obstructive lung disease (HP:0006536)2.44542655
85Chronic obstructive pulmonary disease (HP:0006510)2.44542655
86Bronchitis (HP:0012387)2.44016173
87Secondary amenorrhea (HP:0000869)2.42218349
88Abnormality of cells of the lymphoid lineage (HP:0012140)2.41991540
89Hypergonadotropic hypogonadism (HP:0000815)2.38586894
90Spontaneous hematomas (HP:0007420)2.37590960
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36317585
92Increased intramyocellular lipid droplets (HP:0012240)2.34840522
93Abnormality of chromosome stability (HP:0003220)2.34642059
94Aplastic anemia (HP:0001915)2.34118984
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.32956714
96Papillary thyroid carcinoma (HP:0002895)2.30421553
97Abnormal hair whorl (HP:0010721)2.28974580
98Hemoptysis (HP:0002105)2.28154838
99Gastrointestinal inflammation (HP:0004386)2.27749450
100Hyperventilation (HP:0002883)2.27106857
101Facial hemangioma (HP:0000329)2.26218044
102Aplasia/Hypoplasia of the uvula (HP:0010293)2.25947749
103Hypergammaglobulinemia (HP:0010702)2.25872338
104Stomach cancer (HP:0012126)2.25095822
105Exertional dyspnea (HP:0002875)2.24769820
106Broad-based gait (HP:0002136)2.24471351
107Premature loss of primary teeth (HP:0006323)2.23814694
108Chronic sinusitis (HP:0011109)2.23773908
109Recurrent gram-negative bacterial infections (HP:0005420)2.22688900
110True hermaphroditism (HP:0010459)2.21552435
111Medial flaring of the eyebrow (HP:0010747)2.21206834
112Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20933230
113Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20933230
114Gangrene (HP:0100758)2.19877069
115Chest pain (HP:0100749)2.19647361
116Acute encephalopathy (HP:0006846)2.18295421
117Meckel diverticulum (HP:0002245)2.17538069
118Hepatic necrosis (HP:0002605)2.16963353
119Progressive macrocephaly (HP:0004481)2.16359690
120Congenital primary aphakia (HP:0007707)2.15910486
121Aplasia/Hypoplasia of the tibia (HP:0005772)2.15542175
122Fetal akinesia sequence (HP:0001989)2.15484618
123Autoimmune thrombocytopenia (HP:0001973)2.15337561
124Nephrogenic diabetes insipidus (HP:0009806)2.13941308
125Adrenal hypoplasia (HP:0000835)2.12494242
126Urticaria (HP:0001025)2.12059024
127Short tibia (HP:0005736)2.10527139
128Unsteady gait (HP:0002317)2.09869743
129Small intestinal stenosis (HP:0012848)2.07870606
130Duodenal stenosis (HP:0100867)2.07870606
131Hypochromic microcytic anemia (HP:0004840)2.06945661
132Pancreatic cysts (HP:0001737)2.06869462
133Thyroid-stimulating hormone excess (HP:0002925)2.06712444
134Lipid accumulation in hepatocytes (HP:0006561)2.06534488
135Gait imbalance (HP:0002141)2.05844326
136Amyotrophic lateral sclerosis (HP:0007354)2.05325045
137Prostate neoplasm (HP:0100787)2.04562442
138Myelodysplasia (HP:0002863)2.04426228
139Anorexia (HP:0002039)2.03157428
140Aplasia/Hypoplasia of the breasts (HP:0010311)2.02515832
141Alveolar cell carcinoma (HP:0006519)2.02337340
142Renal Fanconi syndrome (HP:0001994)2.01965678
143Breast aplasia (HP:0100783)2.01530388
144Clubbing of toes (HP:0100760)2.00092486
145Cerebral hypomyelination (HP:0006808)1.99731884
146Infertility (HP:0000789)1.99731586
147Neutropenia (HP:0001875)1.99347839
148Abnormality of the fovea (HP:0000493)1.99287163
149Abnormality of the ileum (HP:0001549)1.98377772
150IgA deficiency (HP:0002720)1.97860903
151Flat capital femoral epiphysis (HP:0003370)1.97847156
152Skin rash (HP:0000988)1.97632009
153Gaze-evoked nystagmus (HP:0000640)1.97131651
154Hepatosplenomegaly (HP:0001433)1.96154779
155Recurrent sinusitis (HP:0011108)1.95633803
156Delusions (HP:0000746)1.94860759
157Abnormal lung lobation (HP:0002101)1.94824975
158Joint swelling (HP:0001386)1.94381685
159Abnormality of lateral ventricle (HP:0030047)1.94375321
160Hypothermia (HP:0002045)1.92673483
161Abnormality of glycolysis (HP:0004366)1.92597088
162Increased serum pyruvate (HP:0003542)1.92597088
163Hypoplasia of the fovea (HP:0007750)1.91878979
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.91878979
165Arterial thrombosis (HP:0004420)1.91109961
166Abnormality of the pleura (HP:0002103)1.89300318
167Fair hair (HP:0002286)1.89294588
168Inability to walk (HP:0002540)1.89256537
169Pulmonary embolism (HP:0002204)1.89227592
170Verrucae (HP:0200043)1.88391327
171Papilloma (HP:0012740)1.88391327
172Poor coordination (HP:0002370)1.87886532
173Lactic acidosis (HP:0003128)1.86673269
174Optic neuritis (HP:0100653)1.84818712
175Retrobulbar optic neuritis (HP:0100654)1.84818712
176Increased serum lactate (HP:0002151)1.84198712
177Exercise intolerance (HP:0003546)1.82570869
178Hematochezia (HP:0002573)1.82277601
179Neoplasm of the tracheobronchial system (HP:0100552)1.82253924
180Molar tooth sign on MRI (HP:0002419)1.80339223
181Abnormality of midbrain morphology (HP:0002418)1.80339223
182Agnosia (HP:0010524)1.79805223
183Abolished electroretinogram (ERG) (HP:0000550)1.79238732
184Amaurosis fugax (HP:0100576)1.79080318
185CNS hypomyelination (HP:0003429)1.79053060
186Microcytic anemia (HP:0001935)1.78433833
187Type I transferrin isoform profile (HP:0003642)1.77798879
188Female pseudohermaphroditism (HP:0010458)1.77702994
189Osteomyelitis (HP:0002754)1.75991127
190Petechiae (HP:0000967)1.75635232
191Colitis (HP:0002583)1.75443891
192Pancytopenia (HP:0001876)1.75440535
193Keratitis (HP:0000491)1.73565473
194Acute hepatic failure (HP:0006554)1.73033231
195Sepsis (HP:0100806)1.72988862
196Prolonged bleeding time (HP:0003010)1.70749489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.43404429
2BMPR23.95781177
3MAP4K13.80115664
4MOS3.26150597
5MUSK3.01109928
6MAP3K132.85426227
7BRAF2.79443872
8ARAF2.78709700
9MAP2K72.50176800
10MAP3K62.48281760
11CCNB12.44331335
12MAP3K122.43886119
13MKNK22.41973598
14FES2.34424665
15TAOK32.31020857
16MAP4K22.27090031
17TNIK2.20052053
18JAK32.16687687
19TYK22.15719450
20PLK42.15593933
21NUAK12.14882213
22KSR22.14661143
23EPHA42.10856306
24MAP3K142.07263264
25RAF12.05470657
26MAP3K92.04474182
27MAPKAPK32.00996096
28TESK21.94895586
29MST41.93840473
30CDK191.91121096
31KDR1.82793932
32CSK1.81753784
33BUB11.79312763
34ITK1.79122121
35SYK1.78416340
36BTK1.64685895
37CDK81.64076306
38JAK11.63803668
39TTK1.60657972
40BCKDK1.52888766
41BLK1.47608299
42ZAP701.44585721
43CSF1R1.41756490
44LCK1.40067962
45LYN1.39188938
46MAPK131.38585492
47TBK11.38130887
48CDC71.37166616
49MAP3K41.31969473
50PLK21.30904670
51EEF2K1.26616395
52MKNK11.25699376
53ACVR1B1.25423811
54IKBKB1.25170731
55VRK21.24892398
56IRAK41.23382671
57ZAK1.22312034
58LATS21.20445712
59NLK1.20123647
60MAPKAPK51.19382340
61KSR11.18709424
62RIPK41.16333898
63DAPK11.15001262
64STK38L1.12895603
65TRIM281.08793497
66HCK1.06796048
67MELK1.04730649
68BRSK21.04003759
69PIM11.00673277
70MARK30.96616399
71VRK10.95485091
72ERBB40.94986866
73PRKCQ0.93966814
74BCR0.93921349
75DAPK20.90081562
76PLK10.89479295
77AKT30.89023371
78ERBB30.88270390
79PASK0.87850092
80PRKD20.85591026
81JAK20.85269733
82TXK0.84643795
83CDK60.83329791
84CDK30.80554555
85PAK60.79156529
86RPS6KA40.76600402
87EIF2AK10.75988379
88TGFBR10.74523787
89SRPK10.73587616
90CHEK20.73379633
91CDK90.72226575
92SIK30.71982097
93MAP2K40.71838826
94STK160.71425772
95TGFBR20.70299520
96OXSR10.70102880
97DYRK20.69427775
98MATK0.64458375
99STK100.63898775
100SGK20.63230167
101PLK30.62722570
102IRAK10.62468917
103TSSK60.61741079
104DYRK30.60819083
105NEK90.60135570
106STK380.59618004
107CAMK2A0.57414465
108BMPR1B0.54070747
109AURKA0.51756386
110MYLK0.51671508
111EIF2AK20.51163267
112TAOK10.50926714
113NTRK30.50785681
114MAP2K20.50066272
115NEK20.48340816
116PINK10.48236814
117NEK10.45770245
118TLK10.45672237
119MAPK70.45023850
120CAMKK20.43500732
121CSNK1G10.43199515
122CLK10.43059025
123CDK40.42986991
124TNK20.42948325
125YES10.42819588
126IGF1R0.41842592
127FYN0.41685681
128PIK3CG0.41030992
129AURKB0.40709429
130STK40.40601661
131STK240.39334502
132KIT0.38576603
133WEE10.38304098
134EIF2AK30.38015139
135RPS6KB20.36607389
136MAP3K110.36451369
137CSNK1G20.34869602
138TEC0.34861753
139GRK10.34398225
140EGFR0.33439870
141SCYL20.32973547
142ADRBK20.32052283
143CSNK1G30.31485461
144EPHA30.30704221
145NEK60.30442338
146MAPK110.29263321
147SGK4940.28519632
148SGK2230.28519632
149NME10.28213858
150FGR0.26706603
151MAPKAPK20.26519954
152PRKAA20.26514724
153GRK50.26500853
154TRPM70.26175448
155MAP3K50.23963000
156MAP3K10.21840479
157MAP3K80.20538703
158GRK60.19427365
159ABL20.19120859
160IKBKE0.18949252
161PRPF4B0.18943962
162PTK2B0.18665353
163GRK70.18156800

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.60383959
2Allograft rejection_Homo sapiens_hsa053303.60023142
3Autoimmune thyroid disease_Homo sapiens_hsa053203.56272754
4Basal transcription factors_Homo sapiens_hsa030223.21226324
5Antigen processing and presentation_Homo sapiens_hsa046123.03557180
6RNA polymerase_Homo sapiens_hsa030203.03427261
7RNA degradation_Homo sapiens_hsa030183.01792159
8Cell cycle_Homo sapiens_hsa041102.79199937
9DNA replication_Homo sapiens_hsa030302.60721023
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.60050176
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.57555018
12Homologous recombination_Homo sapiens_hsa034402.50221064
13Circadian rhythm_Homo sapiens_hsa047102.45909900
14Type I diabetes mellitus_Homo sapiens_hsa049402.42568330
15Asthma_Homo sapiens_hsa053102.40212666
16Hematopoietic cell lineage_Homo sapiens_hsa046402.39014098
17Oocyte meiosis_Homo sapiens_hsa041142.25049849
18Nicotine addiction_Homo sapiens_hsa050332.19161521
19Fanconi anemia pathway_Homo sapiens_hsa034602.16362986
20Leishmaniasis_Homo sapiens_hsa051402.11783980
21Measles_Homo sapiens_hsa051622.09998309
22NF-kappa B signaling pathway_Homo sapiens_hsa040642.02327780
23Base excision repair_Homo sapiens_hsa034102.00044288
24Ovarian steroidogenesis_Homo sapiens_hsa049131.97574298
25Mismatch repair_Homo sapiens_hsa034301.84609652
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77434545
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77171978
28Nucleotide excision repair_Homo sapiens_hsa034201.75528909
29Staphylococcus aureus infection_Homo sapiens_hsa051501.74069704
30Non-homologous end-joining_Homo sapiens_hsa034501.71072686
31Viral myocarditis_Homo sapiens_hsa054161.70625759
32Oxidative phosphorylation_Homo sapiens_hsa001901.70202784
33Collecting duct acid secretion_Homo sapiens_hsa049661.69807707
34Long-term potentiation_Homo sapiens_hsa047201.66188237
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65173187
36Olfactory transduction_Homo sapiens_hsa047401.63934453
37Osteoclast differentiation_Homo sapiens_hsa043801.62624043
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49843246
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47511449
40Pyrimidine metabolism_Homo sapiens_hsa002401.45993257
41Synaptic vesicle cycle_Homo sapiens_hsa047211.44874198
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42856216
43RNA transport_Homo sapiens_hsa030131.41109418
44Purine metabolism_Homo sapiens_hsa002301.39981713
45Vitamin B6 metabolism_Homo sapiens_hsa007501.37836496
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.37161195
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36057347
48Long-term depression_Homo sapiens_hsa047301.32574669
49Amphetamine addiction_Homo sapiens_hsa050311.32377508
50Huntingtons disease_Homo sapiens_hsa050161.26562983
51Glutamatergic synapse_Homo sapiens_hsa047241.26129753
52Legionellosis_Homo sapiens_hsa051341.25951481
53Tuberculosis_Homo sapiens_hsa051521.25526582
54Serotonergic synapse_Homo sapiens_hsa047261.22427930
55B cell receptor signaling pathway_Homo sapiens_hsa046621.22200162
56Proteasome_Homo sapiens_hsa030501.21356028
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21200552
58Spliceosome_Homo sapiens_hsa030401.19487463
59p53 signaling pathway_Homo sapiens_hsa041151.18540302
60GnRH signaling pathway_Homo sapiens_hsa049121.18057130
61Parkinsons disease_Homo sapiens_hsa050121.13375030
62Influenza A_Homo sapiens_hsa051641.13023583
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12935387
64Ether lipid metabolism_Homo sapiens_hsa005651.09397819
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08980446
66Malaria_Homo sapiens_hsa051441.08644262
67Alzheimers disease_Homo sapiens_hsa050101.07522586
68Primary immunodeficiency_Homo sapiens_hsa053401.06145128
69Ribosome_Homo sapiens_hsa030101.04078232
70Regulation of autophagy_Homo sapiens_hsa041401.03153043
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02779833
72Toxoplasmosis_Homo sapiens_hsa051450.98287738
73Chemokine signaling pathway_Homo sapiens_hsa040620.97546206
74Morphine addiction_Homo sapiens_hsa050320.96922174
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92245425
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91170122
77Circadian entrainment_Homo sapiens_hsa047130.90915902
78Thyroid cancer_Homo sapiens_hsa052160.90336022
79Oxytocin signaling pathway_Homo sapiens_hsa049210.88602413
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87118731
81Taste transduction_Homo sapiens_hsa047420.86838513
82Pancreatic cancer_Homo sapiens_hsa052120.86173934
83Dopaminergic synapse_Homo sapiens_hsa047280.84974398
84Protein export_Homo sapiens_hsa030600.84551739
85Calcium signaling pathway_Homo sapiens_hsa040200.82077405
86TNF signaling pathway_Homo sapiens_hsa046680.81769936
87Apoptosis_Homo sapiens_hsa042100.79906721
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79423394
89Caffeine metabolism_Homo sapiens_hsa002320.79277260
90Colorectal cancer_Homo sapiens_hsa052100.78816768
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75808753
92Salivary secretion_Homo sapiens_hsa049700.73547793
93Viral carcinogenesis_Homo sapiens_hsa052030.70271919
94HTLV-I infection_Homo sapiens_hsa051660.69397457
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67964554
96Linoleic acid metabolism_Homo sapiens_hsa005910.65590473
97Phototransduction_Homo sapiens_hsa047440.64908636
98African trypanosomiasis_Homo sapiens_hsa051430.64468550
99Vibrio cholerae infection_Homo sapiens_hsa051100.64272132
100cAMP signaling pathway_Homo sapiens_hsa040240.63949825
101TGF-beta signaling pathway_Homo sapiens_hsa043500.62691160
102Nitrogen metabolism_Homo sapiens_hsa009100.62420116
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60669559
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60662912
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60370330
106Hepatitis C_Homo sapiens_hsa051600.59454528
107Systemic lupus erythematosus_Homo sapiens_hsa053220.58940005
108Peroxisome_Homo sapiens_hsa041460.58749176
109Choline metabolism in cancer_Homo sapiens_hsa052310.57632633
110Ras signaling pathway_Homo sapiens_hsa040140.53683611
111mRNA surveillance pathway_Homo sapiens_hsa030150.53260234
112Pertussis_Homo sapiens_hsa051330.52759876
113VEGF signaling pathway_Homo sapiens_hsa043700.52014238
114Rheumatoid arthritis_Homo sapiens_hsa053230.51996591
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51897771
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.51425365
117Gastric acid secretion_Homo sapiens_hsa049710.51197856
118Renin secretion_Homo sapiens_hsa049240.50962259
119Herpes simplex infection_Homo sapiens_hsa051680.50778348
120Cardiac muscle contraction_Homo sapiens_hsa042600.49078131
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48383144
122Other glycan degradation_Homo sapiens_hsa005110.47781779
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47511967
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46356604
125Epstein-Barr virus infection_Homo sapiens_hsa051690.46145837
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45287379
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45165977
128Phagosome_Homo sapiens_hsa041450.44286336
129Inositol phosphate metabolism_Homo sapiens_hsa005620.43596918
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43424985
131MAPK signaling pathway_Homo sapiens_hsa040100.42504562
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.41936458
133GABAergic synapse_Homo sapiens_hsa047270.41758195
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41676942
135Folate biosynthesis_Homo sapiens_hsa007900.41555865
136Cholinergic synapse_Homo sapiens_hsa047250.41494074
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41220344
138Arachidonic acid metabolism_Homo sapiens_hsa005900.41173414
139Acute myeloid leukemia_Homo sapiens_hsa052210.40670033
140Wnt signaling pathway_Homo sapiens_hsa043100.40625416
141Shigellosis_Homo sapiens_hsa051310.40182052
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.40125079
143FoxO signaling pathway_Homo sapiens_hsa040680.39212524
144Prolactin signaling pathway_Homo sapiens_hsa049170.38393048
145Hepatitis B_Homo sapiens_hsa051610.35686988
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35391037
147T cell receptor signaling pathway_Homo sapiens_hsa046600.35219756
148Insulin secretion_Homo sapiens_hsa049110.35126440
149Platelet activation_Homo sapiens_hsa046110.34654767
150Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33350145
151Salmonella infection_Homo sapiens_hsa051320.32809063
152Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30109948
153Propanoate metabolism_Homo sapiens_hsa006400.29944626
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25961652
155Drug metabolism - other enzymes_Homo sapiens_hsa009830.24276998
156Non-small cell lung cancer_Homo sapiens_hsa052230.23348313
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22408518
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.18912853
159Endocytosis_Homo sapiens_hsa041440.16391856
160Tryptophan metabolism_Homo sapiens_hsa003800.15147884

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