MATK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.63729638
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.34868271
3synaptic vesicle maturation (GO:0016188)6.22683022
4locomotory exploration behavior (GO:0035641)6.00055323
5synaptic vesicle exocytosis (GO:0016079)5.80209909
6positive regulation of gamma-delta T cell activation (GO:0046645)5.79391159
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.74107574
8vocalization behavior (GO:0071625)5.73538560
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.40959455
10regulation of glutamate receptor signaling pathway (GO:1900449)5.38233823
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.36854065
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28813044
13protein localization to synapse (GO:0035418)5.13662536
14regulation of neuronal synaptic plasticity (GO:0048168)5.08629358
15regulation of long-term neuronal synaptic plasticity (GO:0048169)5.06762877
16regulation of synaptic vesicle exocytosis (GO:2000300)5.04655454
17glutamate secretion (GO:0014047)5.03841343
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.95251593
19synaptic transmission, glutamatergic (GO:0035249)4.80896475
20regulation of synapse structural plasticity (GO:0051823)4.77411939
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.76886857
22neuronal action potential propagation (GO:0019227)4.74335689
23exploration behavior (GO:0035640)4.70971478
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.70195350
25negative regulation of cell killing (GO:0031342)4.70195350
26glutamate receptor signaling pathway (GO:0007215)4.68197544
27regulation of synaptic vesicle transport (GO:1902803)4.66443472
28response to peptidoglycan (GO:0032494)4.50093970
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.48476851
30negative regulation of interleukin-12 production (GO:0032695)4.47960624
31neurotransmitter secretion (GO:0007269)4.46991426
32positive regulation of membrane potential (GO:0045838)4.46476693
33long-term memory (GO:0007616)4.45626321
34regulation of B cell receptor signaling pathway (GO:0050855)4.41335671
35neuron-neuron synaptic transmission (GO:0007270)4.41199722
36neurotransmitter-gated ion channel clustering (GO:0072578)4.37690778
37regulation of excitatory postsynaptic membrane potential (GO:0060079)4.35730041
38negative regulation of erythrocyte differentiation (GO:0045647)4.30635530
39neutrophil activation involved in immune response (GO:0002283)4.22164278
40regulation of gamma-delta T cell differentiation (GO:0045586)4.21372994
41neuron cell-cell adhesion (GO:0007158)4.20945837
42regulation of gamma-delta T cell activation (GO:0046643)4.19610838
43positive regulation of B cell differentiation (GO:0045579)4.18387076
44regulation of synaptic plasticity (GO:0048167)4.09616000
45positive regulation of neurotransmitter secretion (GO:0001956)4.06456091
46G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.04996737
47regulation of postsynaptic membrane potential (GO:0060078)4.04525702
48regulation of dendritic spine morphogenesis (GO:0061001)4.03016053
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97128309
50dendritic spine morphogenesis (GO:0060997)3.95255586
51positive regulation of neurotransmitter transport (GO:0051590)3.90831031
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.88158040
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.86915858
54positive regulation of synapse maturation (GO:0090129)3.82340929
55regulation of glutamate secretion (GO:0014048)3.79499641
56long-term synaptic potentiation (GO:0060291)3.77462877
57behavioral defense response (GO:0002209)3.77155288
58behavioral fear response (GO:0001662)3.77155288
59gamma-aminobutyric acid transport (GO:0015812)3.76960893
60transmission of nerve impulse (GO:0019226)3.72908271
61mucosal-associated lymphoid tissue development (GO:0048537)3.68722834
62Peyers patch development (GO:0048541)3.68722834
63regulation of vesicle fusion (GO:0031338)3.67074863
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.66494411
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.63601631
66positive regulation of dendritic spine development (GO:0060999)3.63450250
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.62080064
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.61930321
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.61337281
70activation of protein kinase A activity (GO:0034199)3.60789113
71proline transport (GO:0015824)3.60721219
72detection of bacterium (GO:0016045)3.60680674
73negative regulation of amino acid transport (GO:0051956)3.60306850
74neurotransmitter transport (GO:0006836)3.58570966
75layer formation in cerebral cortex (GO:0021819)3.56772489
76detection of other organism (GO:0098543)3.55913467
77immunoglobulin mediated immune response (GO:0016064)3.55065145
78cellular potassium ion homeostasis (GO:0030007)3.53595497
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.52863767
80regulation of mast cell degranulation (GO:0043304)3.52122312
81response to histamine (GO:0034776)3.51428804
82neuromuscular process controlling balance (GO:0050885)3.51021336
83leukocyte aggregation (GO:0070486)3.50537524
84regulation of dendritic spine development (GO:0060998)3.49951179
85antigen processing and presentation of endogenous antigen (GO:0019883)3.49725171
86regulation of neurotransmitter secretion (GO:0046928)3.47531661
87macrophage activation involved in immune response (GO:0002281)3.47388207
88positive thymic T cell selection (GO:0045059)3.46054113
89response to protozoan (GO:0001562)3.45118980
90neuromuscular process controlling posture (GO:0050884)3.44794579
91fear response (GO:0042596)3.43270914
92regulation of neurotransmitter levels (GO:0001505)3.42669442
93defense response to protozoan (GO:0042832)3.42568044
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41347892
95prepulse inhibition (GO:0060134)3.40155832
96synaptic vesicle endocytosis (GO:0048488)3.40137948
97membrane depolarization (GO:0051899)3.39343537
98learning (GO:0007612)3.39201907
99postsynaptic membrane organization (GO:0001941)3.37340303
100response to muramyl dipeptide (GO:0032495)3.36529825
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33462064
102neuronal ion channel clustering (GO:0045161)3.32837512
103mature B cell differentiation involved in immune response (GO:0002313)3.32605649
104lipopolysaccharide-mediated signaling pathway (GO:0031663)3.31897453
105granulocyte activation (GO:0036230)3.30008885
106antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.29832383
107regulation of neurotransmitter transport (GO:0051588)3.29652595
108dendritic spine organization (GO:0097061)3.28883402
109auditory behavior (GO:0031223)3.28629892
110regulation of B cell differentiation (GO:0045577)3.28115776
111positive regulation of synaptic transmission (GO:0050806)3.26360627
112neuron recognition (GO:0008038)3.24246536
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23967612
114negative regulation of synaptic transmission, GABAergic (GO:0032229)3.23684170
115visual learning (GO:0008542)3.23310765
116respiratory burst (GO:0045730)3.21681345
117regulation of synaptic transmission (GO:0050804)3.21300395
118ganglioside metabolic process (GO:0001573)3.20366473
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19978985
120regulation of interleukin-2 biosynthetic process (GO:0045076)3.18288120
121germinal center formation (GO:0002467)3.18279971
122regulation of mast cell activation involved in immune response (GO:0033006)3.17940337
123myeloid cell activation involved in immune response (GO:0002275)3.16965175
124synaptic transmission, dopaminergic (GO:0001963)3.16879486
125myeloid dendritic cell activation (GO:0001773)3.16642788
126cellular extravasation (GO:0045123)3.16616889
127response to auditory stimulus (GO:0010996)3.14951556
128behavioral response to cocaine (GO:0048148)3.14336311
129membrane hyperpolarization (GO:0060081)3.14311886
130NIK/NF-kappaB signaling (GO:0038061)3.14057990
131regulation of female receptivity (GO:0045924)3.12841531
132positive regulation of mast cell activation (GO:0033005)3.12426518
133T cell migration (GO:0072678)3.12291763
134sodium ion export (GO:0071436)3.11168461
135positive regulation by symbiont of host defense response (GO:0052509)3.10657279
136modulation by symbiont of host defense response (GO:0052031)3.10657279
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10657279
138modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10657279
139positive regulation by organism of defense response of other organism involved in symbiotic interact3.10657279
140modulation by symbiont of host immune response (GO:0052553)3.10657279
141membrane depolarization during action potential (GO:0086010)3.09944092
142synaptic transmission (GO:0007268)3.09924583
143myeloid dendritic cell differentiation (GO:0043011)3.06917736
144regulation of voltage-gated calcium channel activity (GO:1901385)3.06898621
145visual behavior (GO:0007632)3.06851825
146response to amphetamine (GO:0001975)3.06609325
147regulation of leukocyte degranulation (GO:0043300)3.05946437
148neutrophil activation (GO:0042119)3.05810236
149associative learning (GO:0008306)3.03789439
150negative regulation of nitric oxide biosynthetic process (GO:0045019)3.02517037
151regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02498009
152regulation of natural killer cell mediated immunity (GO:0002715)3.02398239
153regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.02398239
154oligosaccharide catabolic process (GO:0009313)2.99587560
155social behavior (GO:0035176)2.99089932
156intraspecies interaction between organisms (GO:0051703)2.99089932
157regulation of protein kinase A signaling (GO:0010738)2.98566020
158dopamine receptor signaling pathway (GO:0007212)2.97089625
159regulation of synapse maturation (GO:0090128)2.96606109
160response to interleukin-15 (GO:0070672)2.95913555
161negative regulation of myeloid cell apoptotic process (GO:0033033)2.94905893
162positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94665935
163cellular response to interleukin-15 (GO:0071350)2.94198257
164regulation of mast cell activation (GO:0033003)2.92964663
165negative thymic T cell selection (GO:0045060)2.92115429
166Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91405140
167cellular response to thyroid hormone stimulus (GO:0097067)2.91259258
168positive regulation of antigen processing and presentation (GO:0002579)2.88998745
169negative regulation of leukocyte mediated immunity (GO:0002704)2.88148075
170positive regulation of mast cell degranulation (GO:0043306)2.87503723
171positive regulation of mast cell activation involved in immune response (GO:0033008)2.87503723
172leukocyte degranulation (GO:0043299)2.85418984
173negative regulation of T cell mediated immunity (GO:0002710)2.85201430
174activated T cell proliferation (GO:0050798)2.84840663
175cellular response to type I interferon (GO:0071357)2.79524163
176type I interferon signaling pathway (GO:0060337)2.79524163
177negative regulation of phagocytosis (GO:0050765)2.78818504
178regulation of antigen processing and presentation (GO:0002577)2.78640573
179response to type I interferon (GO:0034340)2.78348407
180negative regulation of lymphocyte mediated immunity (GO:0002707)2.78163946
181negative T cell selection (GO:0043383)2.77129606
182positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.76247129
183interferon-gamma-mediated signaling pathway (GO:0060333)2.76221937
184negative regulation of cytokine production involved in immune response (GO:0002719)2.74743574
185negative regulation of innate immune response (GO:0045824)2.71896191
186response to thyroid hormone (GO:0097066)2.71022745
187amino sugar catabolic process (GO:0046348)2.70444602
188detection of external biotic stimulus (GO:0098581)2.70086762
189glycosphingolipid catabolic process (GO:0046479)2.69765611
190B cell mediated immunity (GO:0019724)2.67159888
191regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.65979946
192B cell receptor signaling pathway (GO:0050853)2.65679039
193regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65658656
194regulation of alpha-beta T cell proliferation (GO:0046640)2.64139060
195regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.62320152
196regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.61791698
197positive T cell selection (GO:0043368)2.61596406
198regulation of regulated secretory pathway (GO:1903305)2.60458815
199positive regulation of granulocyte differentiation (GO:0030854)2.59411301
200thymic T cell selection (GO:0045061)2.59202798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.26169779
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.07328080
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.46769888
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.89661473
5VDR_21846776_ChIP-Seq_THP-1_Human3.63982671
6GBX2_23144817_ChIP-Seq_PC3_Human3.48248969
7RARB_27405468_Chip-Seq_BRAIN_Mouse3.42587525
8GATA1_22025678_ChIP-Seq_K562_Human3.36804002
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.30879150
10JARID2_20064375_ChIP-Seq_MESCs_Mouse3.29514286
11SCL_19346495_ChIP-Seq_HPC-7_Human3.25443888
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15021242
13REST_21632747_ChIP-Seq_MESCs_Mouse3.05421653
14IKZF1_21737484_ChIP-ChIP_HCT116_Human3.05201365
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02993522
16DROSHA_22980978_ChIP-Seq_HELA_Human2.97508607
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83206282
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.80250311
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75437309
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74601100
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74360441
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74360441
23MYC_22102868_ChIP-Seq_BL_Human2.74025426
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.70142851
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.68769770
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.66128102
27* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64197477
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56761291
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55912518
30VDR_24763502_ChIP-Seq_THP-1_Human2.53981459
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.53587446
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52307325
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.48667694
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.46662494
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46499650
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.46341209
37EZH2_27304074_Chip-Seq_ESCs_Mouse2.44417351
38* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33966444
39* SPI1_23547873_ChIP-Seq_NB4_Human2.25464856
40RNF2_27304074_Chip-Seq_ESCs_Mouse2.20883014
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18248753
42MAF_26560356_Chip-Seq_TH1_Human2.16937241
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16342932
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14741020
45EED_16625203_ChIP-ChIP_MESCs_Mouse2.10151516
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07102181
47RUNX_20019798_ChIP-Seq_JUKART_Human2.06583871
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.06054627
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04735579
50UTX_26944678_Chip-Seq_JUKART_Human2.04025634
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99515129
52MYB_26560356_Chip-Seq_TH2_Human1.99384712
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97952606
54* RUNX1_22412390_ChIP-Seq_EML_Mouse1.97524250
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94156306
56* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91952466
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88966244
58* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86247029
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85591101
60KDM2B_26808549_Chip-Seq_DND41_Human1.84961537
61SPI1_23127762_ChIP-Seq_K562_Human1.84939497
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83117765
63MAF_26560356_Chip-Seq_TH2_Human1.82015371
64AR_21572438_ChIP-Seq_LNCaP_Human1.81847934
65* BCL6_27268052_Chip-Seq_Bcells_Human1.73624106
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.73295229
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72875943
68TAF15_26573619_Chip-Seq_HEK293_Human1.71049582
69* TCF7_22412390_ChIP-Seq_EML_Mouse1.67327662
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63359223
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62166830
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.61565578
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60108587
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57430905
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55627418
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54725043
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53825614
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51988615
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48358387
80BCOR_27268052_Chip-Seq_Bcells_Human1.47968561
81SMAD4_21799915_ChIP-Seq_A2780_Human1.44012293
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43936327
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43586149
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40773486
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40295265
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.40064210
87MYB_26560356_Chip-Seq_TH1_Human1.39811512
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39684400
89* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.39681165
90* P68_20966046_ChIP-Seq_HELA_Human1.39633400
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37146876
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35575311
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34982762
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34790497
95GATA3_27048872_Chip-Seq_THYMUS_Human1.33866313
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.33620153
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33468911
98* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31079231
99* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30888117
100ZNF274_21170338_ChIP-Seq_K562_Hela1.30275839
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29950603
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29406518
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29371571
104* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28182080
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27385620
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24375724
107* SA1_27219007_Chip-Seq_ERYTHROID_Human1.23312349
108SPI1_20517297_ChIP-Seq_HL60_Human1.22454309
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22008691
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21505793
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21467726
112GATA1_19941826_ChIP-Seq_K562_Human1.20995958
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20447664
114* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20398119
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18569591
116VDR_24787735_ChIP-Seq_THP-1_Human1.16800490
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16575269
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16095090
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16032967
120STAT1_20625510_ChIP-Seq_HELA_Human1.15843012
121* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15088532
122NCOR1_26117541_ChIP-Seq_K562_Human1.14951064
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.13868477
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13859531
125CTCF_26484167_Chip-Seq_Bcells_Mouse1.13828214
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12952267
127EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12497417
128SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12207000
129AR_25329375_ChIP-Seq_VCAP_Human1.12048508
130* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11976102
131* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09578614
132P300_19829295_ChIP-Seq_ESCs_Human1.09536178
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08667828
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07494280
135ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07386066
136SMAD3_21741376_ChIP-Seq_EPCs_Human1.07356888
137GATA3_26560356_Chip-Seq_TH2_Human1.07080786
138SMAD_19615063_ChIP-ChIP_OVARY_Human1.07015393
139CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06868054
140P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06671744
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05726787
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05706637
143AR_19668381_ChIP-Seq_PC3_Human1.05463610
144EGR1_19374776_ChIP-ChIP_THP-1_Human1.05194711
145WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04885234
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03250444
147* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03035073
148PHF8_20622854_ChIP-Seq_HELA_Human1.02695885
149* KDM2B_26808549_Chip-Seq_K562_Human1.02484562
150NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01867878
151* E2F1_20622854_ChIP-Seq_HELA_Human1.01396610
152* PU_27001747_Chip-Seq_BMDM_Mouse1.01258840
153ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00655135
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99608702
155CTCF_27219007_Chip-Seq_Bcells_Human0.98787554
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.98551155
157KDM2B_26808549_Chip-Seq_JURKAT_Human0.98329238
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97886410
159YY1_22570637_ChIP-Seq_MALME-3M_Human0.97517523
160STAT3_23295773_ChIP-Seq_U87_Human0.93097350
161TCF4_23295773_ChIP-Seq_U87_Human0.92314000
162SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91375266
163RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90617459
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90466843
165KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89918179
166TET1_21490601_ChIP-Seq_MESCs_Mouse0.89580698
167RING1B_27294783_Chip-Seq_NPCs_Mouse0.89041551
168GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87463351
169TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86711266
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85011948
171CBX2_27304074_Chip-Seq_ESCs_Mouse0.84400636
172PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83465093
173IGF1R_20145208_ChIP-Seq_DFB_Human0.82184674
174OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81603360
175SMAD3_21741376_ChIP-Seq_HESCs_Human0.81601129
176SMAD3_21741376_ChIP-Seq_ESCs_Human0.80741962
177BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79711045
178RUNX2_22187159_ChIP-Seq_PCA_Human0.77986836
179CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76964254
180TP53_16413492_ChIP-PET_HCT116_Human0.75713930
181LXR_22292898_ChIP-Seq_THP-1_Human0.75509110
182SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75438729
183RNF2_27304074_Chip-Seq_NSC_Mouse0.75094331
184* JUN_21703547_ChIP-Seq_K562_Human0.74811047
185FUS_26573619_Chip-Seq_HEK293_Human0.74508565
186LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71555817
187SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.71421200
188SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71159111
189* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.71059054
190TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70713014
191POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.70713014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.45102721
2MP0003880_abnormal_central_pattern5.32515614
3MP0003635_abnormal_synaptic_transmissio4.43921507
4MP0002822_catalepsy4.04490664
5MP0009745_abnormal_behavioral_response3.81782096
6MP0003436_decreased_susceptibility_to3.63914298
7MP0002063_abnormal_learning/memory/cond3.54925831
8MP0002064_seizures3.36285148
9MP0005671_abnormal_response_to3.35619314
10MP0004270_analgesia3.28181773
11MP0006082_CNS_inflammation3.27933525
12MP0001968_abnormal_touch/_nociception3.05589866
13MP0003724_increased_susceptibility_to3.05266023
14MP0009278_abnormal_bone_marrow3.04581973
15MP0002148_abnormal_hypersensitivity_rea3.01770582
16MP0001835_abnormal_antigen_presentation2.99859894
17MP0009046_muscle_twitch2.95843915
18MP0005423_abnormal_somatic_nervous2.95241235
19MP0002572_abnormal_emotion/affect_behav2.94203056
20MP0005000_abnormal_immune_tolerance2.83663722
21MP0002419_abnormal_innate_immunity2.78515909
22MP0005025_abnormal_response_to2.73783231
23MP0005058_abnormal_lysosome_morphology2.67868078
24MP0002272_abnormal_nervous_system2.63941875
25MP0001501_abnormal_sleep_pattern2.58830913
26MP0003763_abnormal_thymus_physiology2.56898946
27MP0001486_abnormal_startle_reflex2.55336401
28MP0001790_abnormal_immune_system2.54630100
29MP0005387_immune_system_phenotype2.54630100
30MP0009333_abnormal_splenocyte_physiolog2.50184275
31MP0001800_abnormal_humoral_immune2.43894459
32MP0002723_abnormal_immune_serum2.42620656
33MP0002736_abnormal_nociception_after2.42391445
34MP0009785_altered_susceptibility_to2.41099542
35MP0002452_abnormal_antigen_presenting2.39843045
36MP0002420_abnormal_adaptive_immunity2.37535972
37MP0001819_abnormal_immune_cell2.35275465
38MP0002734_abnormal_mechanical_nocicepti2.24960030
39MP0005464_abnormal_platelet_physiology2.17054345
40MP0002735_abnormal_chemical_nociception2.15625857
41MP0002405_respiratory_system_inflammati2.05152289
42MP0000685_abnormal_immune_system1.96950717
43* MP0001545_abnormal_hematopoietic_system1.95056167
44* MP0005397_hematopoietic_system_phenotyp1.95056167
45MP0001970_abnormal_pain_threshold1.94088175
46MP0008569_lethality_at_weaning1.93123795
47MP0002733_abnormal_thermal_nociception1.92424692
48MP0001440_abnormal_grooming_behavior1.92182319
49MP0003879_abnormal_hair_cell1.83798985
50* MP0002398_abnormal_bone_marrow1.83666510
51MP0000716_abnormal_immune_system1.81560278
52MP0002067_abnormal_sensory_capabilities1.79692842
53MP0003806_abnormal_nucleotide_metabolis1.78139229
54MP0003329_amyloid_beta_deposits1.77302320
55MP0003300_gastrointestinal_ulcer1.77144848
56MP0001533_abnormal_skeleton_physiology1.76366395
57MP0004811_abnormal_neuron_physiology1.71488261
58MP0002557_abnormal_social/conspecific_i1.69945637
59MP0001845_abnormal_inflammatory_respons1.68736430
60MP0002909_abnormal_adrenal_gland1.65296231
61MP0005451_abnormal_body_composition1.62070332
62MP0000689_abnormal_spleen_morphology1.62033505
63MP0003191_abnormal_cellular_cholesterol1.61337013
64MP0004947_skin_inflammation1.61146943
65MP0005646_abnormal_pituitary_gland1.60115914
66MP0004924_abnormal_behavior1.59518402
67MP0005386_behavior/neurological_phenoty1.59518402
68MP0002722_abnormal_immune_system1.57688492
69MP0008469_abnormal_protein_level1.53355778
70MP0001905_abnormal_dopamine_level1.52758252
71MP0001873_stomach_inflammation1.52233512
72MP0009840_abnormal_foam_cell1.50828875
73MP0003787_abnormal_imprinting1.50236259
74MP0003075_altered_response_to1.49698733
75MP0000465_gastrointestinal_hemorrhage1.49465175
76MP0004142_abnormal_muscle_tone1.49081685
77MP0001529_abnormal_vocalization1.48949227
78MP0002429_abnormal_blood_cell1.48514721
79MP0009764_decreased_sensitivity_to1.46081174
80MP0010155_abnormal_intestine_physiology1.45039535
81MP0004858_abnormal_nervous_system1.44076928
82MP0002184_abnormal_innervation1.42441008
83MP0003633_abnormal_nervous_system1.41757697
84MP0009780_abnormal_chondrocyte_physiolo1.40012823
85MP0002066_abnormal_motor_capabilities/c1.34817317
86MP0000703_abnormal_thymus_morphology1.33573181
87MP0001853_heart_inflammation1.32834764
88MP0000955_abnormal_spinal_cord1.32310445
89MP0001188_hyperpigmentation1.30770456
90MP0004885_abnormal_endolymph1.30581203
91MP0001984_abnormal_olfaction1.27281991
92MP0000778_abnormal_nervous_system1.26574911
93MP0001502_abnormal_circadian_rhythm1.24342049
94MP0008874_decreased_physiological_sensi1.23633934
95MP0002882_abnormal_neuron_morphology1.22818885
96MP0006276_abnormal_autonomic_nervous1.22648437
97MP0002998_abnormal_bone_remodeling1.21714328
98MP0008872_abnormal_physiological_respon1.20673388
99MP0000343_altered_response_to1.20179471
100MP0005645_abnormal_hypothalamus_physiol1.18604974
101MP0002396_abnormal_hematopoietic_system1.15396192
102MP0003631_nervous_system_phenotype1.11883358
103MP0003866_abnormal_defecation1.07107207
104MP0002139_abnormal_hepatobiliary_system1.05622248
105MP0005409_darkened_coat_color1.04177062
106* MP0004808_abnormal_hematopoietic_stem1.02986062
107MP0001851_eye_inflammation1.02273899
108MP0003122_maternal_imprinting1.01106614
109MP0000490_abnormal_crypts_of1.00384370
110MP0000751_myopathy0.98244236
111MP0003448_altered_tumor_morphology0.97524606
112MP0000858_altered_metastatic_potential0.97111451
113MP0004510_myositis0.96305942
114MP0003690_abnormal_glial_cell0.94987680
115MP0005535_abnormal_body_temperature0.94233416
116MP0008961_abnormal_basal_metabolism0.91858311
117MP0002069_abnormal_eating/drinking_beha0.91710584
118MP0002152_abnormal_brain_morphology0.91359178
119MP0000604_amyloidosis0.90904134
120MP0003172_abnormal_lysosome_physiology0.90137031
121MP0005167_abnormal_blood-brain_barrier0.88519225
122MP0002229_neurodegeneration0.85760784
123MP0000920_abnormal_myelination0.84166352
124MP0009763_increased_sensitivity_to0.80352637
125MP0009765_abnormal_xenobiotic_induced0.78488045
126MP0001177_atelectasis0.77856829
127MP0001663_abnormal_digestive_system0.77785827
128MP0002693_abnormal_pancreas_physiology0.77162304
129MP0001664_abnormal_digestion0.75315368
130MP0003656_abnormal_erythrocyte_physiolo0.74385109
131MP0001963_abnormal_hearing_physiology0.71514287
132MP0005319_abnormal_enzyme/_coenzyme0.70779475
133MP0002876_abnormal_thyroid_physiology0.70257025
134MP0004085_abnormal_heartbeat0.68993296
135MP0002933_joint_inflammation0.68729345
136MP0002019_abnormal_tumor_incidence0.68269843
137MP0005390_skeleton_phenotype0.67984866
138MP0005647_abnormal_sex_gland0.66088045
139MP0005166_decreased_susceptibility_to0.65994127
140MP0006036_abnormal_mitochondrial_physio0.65414872
141MP0003828_pulmonary_edema0.65344359
142MP0002138_abnormal_hepatobiliary_system0.64993754
143MP0003632_abnormal_nervous_system0.64350526
144MP0004145_abnormal_muscle_electrophysio0.62830684
145MP0003634_abnormal_glial_cell0.62618438
146MP0002132_abnormal_respiratory_system0.61522205
147MP0005551_abnormal_eye_electrophysiolog0.61343996
148MP0002090_abnormal_vision0.61277144
149MP0003183_abnormal_peptide_metabolism0.60736049
150MP0003303_peritoneal_inflammation0.60318833
151MP0003795_abnormal_bone_structure0.59860073
152MP0002332_abnormal_exercise_endurance0.59823104
153MP0005165_increased_susceptibility_to0.57799918
154MP0000631_abnormal_neuroendocrine_gland0.57076335
155MP0004185_abnormal_adipocyte_glucose0.56616615
156MP0000681_abnormal_thyroid_gland0.56568017
157MP0006292_abnormal_olfactory_placode0.56358927
158MP0001765_abnormal_ion_homeostasis0.55694245
159MP0001485_abnormal_pinna_reflex0.55624231
160MP0008873_increased_physiological_sensi0.55337663
161MP0008004_abnormal_stomach_pH0.55302672
162MP0001986_abnormal_taste_sensitivity0.55269907
163MP0005334_abnormal_fat_pad0.54174426
164MP0003453_abnormal_keratinocyte_physiol0.53623163
165MP0004742_abnormal_vestibular_system0.53442935
166MP0002254_reproductive_system_inflammat0.52789066
167MP0010234_abnormal_vibrissa_follicle0.51649096
168MP0010386_abnormal_urinary_bladder0.51585512
169MP0005310_abnormal_salivary_gland0.51051872
170MP0000013_abnormal_adipose_tissue0.49646477
171MP0002752_abnormal_somatic_nervous0.49385525
172MP0003956_abnormal_body_size0.48661011
173MP0005174_abnormal_tail_pigmentation0.48575515
174MP0003123_paternal_imprinting0.47314520
175MP0004484_altered_response_of0.47039879
176MP0002638_abnormal_pupillary_reflex0.44814273
177MP0000015_abnormal_ear_pigmentation0.44245892
178MP0010769_abnormal_survival0.44011302
179MP0001943_abnormal_respiration0.42147936
180MP0010768_mortality/aging0.41838073

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.74869851
2Myokymia (HP:0002411)7.85580817
3Focal seizures (HP:0007359)6.13224976
4Visual hallucinations (HP:0002367)6.05236803
5Eczematoid dermatitis (HP:0000976)5.41831799
6Abnormality of liposaccharide metabolism (HP:0010968)5.25914900
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.25914900
8Abnormality of glycolipid metabolism (HP:0010969)5.25914900
9Epileptic encephalopathy (HP:0200134)5.03782347
10Abnormality of macrophages (HP:0004311)4.97334349
11Recurrent bacterial skin infections (HP:0005406)4.84150911
12Stomatitis (HP:0010280)4.83039967
13Recurrent abscess formation (HP:0002722)4.71746231
14Atonic seizures (HP:0010819)4.60146970
15Increased cerebral lipofuscin (HP:0011813)4.58605813
16Febrile seizures (HP:0002373)4.54456743
17Increased neuronal autofluorescent lipopigment (HP:0002074)4.19584755
18Absence seizures (HP:0002121)4.17937141
19Mediastinal lymphadenopathy (HP:0100721)4.16898574
20Progressive cerebellar ataxia (HP:0002073)4.14668320
21Vacuolated lymphocytes (HP:0001922)4.07928409
22Dialeptic seizures (HP:0011146)3.98162151
23Myositis (HP:0100614)3.92175140
24Generalized tonic-clonic seizures (HP:0002069)3.91306991
25Chronic obstructive pulmonary disease (HP:0006510)3.88658913
26Obstructive lung disease (HP:0006536)3.88658913
27Recurrent gram-negative bacterial infections (HP:0005420)3.83113542
28Poor eye contact (HP:0000817)3.81536616
29Recurrent fungal infections (HP:0002841)3.70300597
30Papilledema (HP:0001085)3.69286575
31Gaze-evoked nystagmus (HP:0000640)3.67802323
32Broad-based gait (HP:0002136)3.67515524
33Supranuclear gaze palsy (HP:0000605)3.63285737
34Dysostosis multiplex (HP:0000943)3.59781338
35Impaired vibration sensation in the lower limbs (HP:0002166)3.54319053
36Elevated erythrocyte sedimentation rate (HP:0003565)3.54245148
37Depression (HP:0000716)3.48228962
38Ankle clonus (HP:0011448)3.37015339
39Anxiety (HP:0000739)3.33776545
40Loss of speech (HP:0002371)3.31685649
41Impaired social interactions (HP:0000735)3.30812437
42Abnormal social behavior (HP:0012433)3.30812437
43Mutism (HP:0002300)3.29247420
44Action tremor (HP:0002345)3.28547011
45Orchitis (HP:0100796)3.27723019
46Postural instability (HP:0002172)3.25655037
47Dysmetria (HP:0001310)3.24045477
48Autoimmune thrombocytopenia (HP:0001973)3.22335624
49Abnormal eating behavior (HP:0100738)3.19344936
50Annular pancreas (HP:0001734)3.18593964
51Recurrent skin infections (HP:0001581)3.17970374
52Retrobulbar optic neuritis (HP:0100654)3.13419120
53Optic neuritis (HP:0100653)3.13419120
54Impaired smooth pursuit (HP:0007772)3.11209399
55Stereotypic behavior (HP:0000733)3.08185617
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.07320718
57Urinary bladder sphincter dysfunction (HP:0002839)3.05906962
58Meningitis (HP:0001287)3.05093655
59Disinhibition (HP:0000734)3.03633694
60Truncal ataxia (HP:0002078)3.02673918
61Dysdiadochokinesis (HP:0002075)3.02673781
62T lymphocytopenia (HP:0005403)3.01513761
63Torticollis (HP:0000473)2.98039067
64Hyperventilation (HP:0002883)2.94484689
65Increased serum ferritin (HP:0003281)2.92616219
66Focal dystonia (HP:0004373)2.88672418
67Recurrent viral infections (HP:0004429)2.87541185
68Petechiae (HP:0000967)2.84295870
69Amblyopia (HP:0000646)2.82752627
70Abnormality of binocular vision (HP:0011514)2.80295417
71Diplopia (HP:0000651)2.80295417
72Progressive inability to walk (HP:0002505)2.80198370
73Chronic mucocutaneous candidiasis (HP:0002728)2.78668555
74Recurrent cutaneous fungal infections (HP:0011370)2.78668555
75Bradykinesia (HP:0002067)2.78517608
76Hepatosplenomegaly (HP:0001433)2.77743426
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.76797388
78Abnormality of T cell number (HP:0011839)2.73566057
79Abnormality of the lower motor neuron (HP:0002366)2.73078881
80Genetic anticipation (HP:0003743)2.71282812
81Scanning speech (HP:0002168)2.67633595
82Abnormality of ocular smooth pursuit (HP:0000617)2.67065012
83Panhypogammaglobulinemia (HP:0003139)2.66872226
84Agnosia (HP:0010524)2.66080071
85Severe visual impairment (HP:0001141)2.65957697
86Encephalitis (HP:0002383)2.63883339
87Hemiplegia (HP:0002301)2.61148664
88Systemic lupus erythematosus (HP:0002725)2.59322046
89Craniofacial dystonia (HP:0012179)2.58496209
90Prolonged bleeding time (HP:0003010)2.56607149
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.52560046
92Spastic gait (HP:0002064)2.51885557
93Pustule (HP:0200039)2.51241450
94Hemiparesis (HP:0001269)2.51043054
95Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49461609
96Abnormality of polysaccharide metabolism (HP:0011012)2.49461609
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49461609
98Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44914597
99Abnormality of iron homeostasis (HP:0011031)2.44756229
100Abnormality of T cells (HP:0002843)2.43455111
101Impaired vibratory sensation (HP:0002495)2.39395599
102Urinary urgency (HP:0000012)2.38578224
103Upper motor neuron abnormality (HP:0002127)2.37882247
104Gastrointestinal inflammation (HP:0004386)2.37391021
105Increased IgM level (HP:0003496)2.37063442
106Purpura (HP:0000979)2.36392934
107Status epilepticus (HP:0002133)2.36151264
108Gingivitis (HP:0000230)2.35661496
109Vasculitis (HP:0002633)2.34355739
110Mucopolysacchariduria (HP:0008155)2.32385531
111Urinary glycosaminoglycan excretion (HP:0003541)2.32385531
112Combined immunodeficiency (HP:0005387)2.29427996
113Keratoconjunctivitis sicca (HP:0001097)2.29301828
114Intention tremor (HP:0002080)2.27850100
115Urticaria (HP:0001025)2.27646620
116Pointed chin (HP:0000307)2.27476633
117Obstructive sleep apnea (HP:0002870)2.26026693
118Prostate neoplasm (HP:0100787)2.25042250
119Dysmetric saccades (HP:0000641)2.24955909
120Inability to walk (HP:0002540)2.23609507
121Inflammation of the large intestine (HP:0002037)2.22560574
122Cellulitis (HP:0100658)2.22346374
123Pulmonary infiltrates (HP:0002113)2.21909618
124Increased IgE level (HP:0003212)2.20731339
125Granulocytopenia (HP:0001913)2.20252203
126Autoimmune hemolytic anemia (HP:0001890)2.19574023
127Cerebral inclusion bodies (HP:0100314)2.19489282
128Psychosis (HP:0000709)2.19087675
129Neurofibrillary tangles (HP:0002185)2.18993759
130Generalized aminoaciduria (HP:0002909)2.18574220
131Excessive salivation (HP:0003781)2.18572366
132Drooling (HP:0002307)2.18572366
133Polyphagia (HP:0002591)2.18258795
134Keratoconjunctivitis (HP:0001096)2.17917145
135Spinal canal stenosis (HP:0003416)2.17764232
136Abnormality of saccadic eye movements (HP:0000570)2.16024435
137Retinal dysplasia (HP:0007973)2.14803118
138Neuronal loss in central nervous system (HP:0002529)2.14534919
139Leukocytosis (HP:0001974)2.14370055
140Hemoptysis (HP:0002105)2.13300362
141Abnormality of the prostate (HP:0008775)2.13044053
142Episodic fever (HP:0001954)2.12987504
143Epileptiform EEG discharges (HP:0011182)2.12065747
144Spontaneous hematomas (HP:0007420)2.11395850
145Epistaxis (HP:0000421)2.10969755
146Generalized myoclonic seizures (HP:0002123)2.09284246
147Lower limb amyotrophy (HP:0007210)2.06471343
148Gastrointestinal infarctions (HP:0005244)2.05612578
149Rigidity (HP:0002063)2.05515746
150Resting tremor (HP:0002322)2.03070906
151Abnormality of transition element cation homeostasis (HP:0011030)2.02764210
152Ventricular fibrillation (HP:0001663)2.02347385
153Type II lissencephaly (HP:0007260)2.01850012
154Incomplete penetrance (HP:0003829)2.01605832
155Inappropriate behavior (HP:0000719)2.00133523
156Personality changes (HP:0000751)2.00025616
157Hypertensive crisis (HP:0100735)1.99410264
158Delusions (HP:0000746)1.98263811
159Absent speech (HP:0001344)1.97336532
160Hematochezia (HP:0002573)1.96538946
161Agammaglobulinemia (HP:0004432)1.96373146
162Global brain atrophy (HP:0002283)1.95935895
163Iris hypopigmentation (HP:0007730)1.94819887
164Lower limb muscle weakness (HP:0007340)1.94808994
165Fetal akinesia sequence (HP:0001989)1.92475529
166Thoracic kyphosis (HP:0002942)1.91916759
167Limb dystonia (HP:0002451)1.91906434
168Ragged-red muscle fibers (HP:0003200)1.91804322
169Decreased circulating renin level (HP:0003351)1.90837218
170Diminished motivation (HP:0000745)1.89937403
171Apathy (HP:0000741)1.89388862
172Gait ataxia (HP:0002066)1.89294271
173Abnormal EKG (HP:0003115)1.89249692
174Axonal loss (HP:0003447)1.89102853
175Protruding tongue (HP:0010808)1.89038939
176Severe combined immunodeficiency (HP:0004430)1.88795372
177Lower limb asymmetry (HP:0100559)1.88280313
178Abnormality of T cell physiology (HP:0011840)1.88149816
179Thrombocytosis (HP:0001894)1.87692655
180Abnormality of B cell number (HP:0010975)1.87257442
181Polyneuropathy (HP:0001271)1.87100902
182Insomnia (HP:0100785)1.85934789
183Dyskinesia (HP:0100660)1.84552819
184Hypergammaglobulinemia (HP:0010702)1.84359183
185EEG with generalized epileptiform discharges (HP:0011198)1.84212160
186Limb ataxia (HP:0002070)1.82889285
187Sleep apnea (HP:0010535)1.82045189
188Chest pain (HP:0100749)1.81989595
189Abnormality of the periventricular white matter (HP:0002518)1.81262551
190Amyotrophic lateral sclerosis (HP:0007354)1.80662636
191Dynein arm defect of respiratory motile cilia (HP:0012255)1.79119443
192Absent/shortened dynein arms (HP:0200106)1.79119443
193Rapidly progressive (HP:0003678)1.77984468
194Ankyloglossia (HP:0010296)1.76382469
195Increased circulating renin level (HP:0000848)1.76199262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.87696289
2NTRK34.89179145
3MAP4K14.00227776
4MAP3K93.83816167
5NME23.54276726
6TXK2.94857574
7TNIK2.93720004
8RIPK42.72949192
9MAP3K112.66552497
10MAP3K122.63943841
11DAPK22.57790238
12TESK22.40382356
13MINK12.37150324
14MAP2K32.33450137
15KSR22.28560555
16MAP3K42.28039498
17MAP2K72.27290241
18FES2.15480643
19DAPK12.15083044
20MAP3K132.13639120
21IRAK32.05183154
22ARAF2.04937510
23TAOK22.00713006
24MAP3K141.97325678
25CAMKK11.96716988
26CDK191.92746026
27TBK11.86595060
28NTRK21.85114032
29MARK11.83626884
30BLK1.81121211
31TAOK31.78689743
32BTK1.78473023
33GRK71.78466769
34PAK61.73849695
35TYK21.72912847
36JAK31.71473291
37CSK1.70536571
38SIK21.66188690
39BCKDK1.65915522
40PRKD31.62521928
41KDR1.61516704
42KIT1.60233961
43IKBKB1.59042821
44IRAK41.56652749
45CDK51.55777449
46KSR11.55075184
47MAP2K41.53605042
48ZAP701.53547338
49RAF11.49666261
50ERN11.49267583
51PRPF4B1.48043320
52PIM21.45698386
53PLK21.45208975
54MATK1.43920191
55TEC1.41596547
56IKBKE1.39561424
57ITK1.38560393
58CAMKK21.30430467
59CAMK11.30122311
60TAOK11.28282129
61CASK1.27609126
62MAPK131.25448309
63GRK51.23168711
64NTRK11.21647747
65LCK1.20471196
66MARK21.13564637
67LYN1.13486977
68PRKCG1.11842937
69TGFBR21.07924428
70TNK21.03767498
71STK381.01307936
72MAP3K30.99042845
73ABL20.93024339
74CSF1R0.90481589
75UHMK10.90268284
76CAMK2A0.89446036
77RPS6KL10.87281467
78RPS6KC10.87281467
79PIM10.87176577
80MAP3K20.86808706
81PTK2B0.86791316
82CAMK2B0.86569548
83TYRO30.85879111
84CDK180.79738559
85CDK150.78696906
86MAP3K10.78399587
87JAK10.78324767
88JAK20.77785247
89STK110.77322577
90PRKCH0.77275335
91PDK10.77002778
92RPS6KA60.76533130
93MUSK0.75654953
94MARK30.72917557
95BMPR20.72743482
96SCYL20.72523883
97CDK11A0.71545468
98CDK140.69692674
99CSNK1G20.68714823
100PINK10.65093810
101MAPK40.63376837
102SGK10.62031643
103PDPK10.61912348
104MAP2K20.61487096
105ALK0.60543163
106CDK40.58121979
107CDC42BPA0.57587308
108SYK0.57285861
109DYRK1A0.56444195
110STK100.56228629
111PNCK0.55214406
112CCNB10.54955172
113PRKCQ0.54373816
114MAP3K70.53781654
115RET0.52943121
116CAMK40.51950713
117MAPK110.50312697
118BRAF0.49774814
119DAPK30.49759457
120FYN0.49013254
121HIPK20.48496405
122IRAK20.46590142
123OXSR10.46554939
124RPS6KA40.46186538
125MAP3K60.46037611
126BRSK10.45003565
127GRK60.42662475
128FGR0.42379359
129MAPK70.41964260
130RPS6KA30.41640253
131MAP2K60.41446547
132TRIB30.41312395
133SGK2230.40613101
134SGK4940.40613101
135MOS0.40507185
136NME10.40449275
137MAP3K50.39822232
138MAPKAPK50.39525252
139SIK30.38186697
140NEK60.38012412
141ADRBK20.37481279
142SGK20.35484577
143RPS6KA10.34603732
144CAMK2G0.34372833
145PRKD20.33409467
146DMPK0.32804298
147TESK10.32761975
148HCK0.32737259
149CAMK2D0.32534349
150PRKCE0.32393844
151PHKG20.32347179
152PHKG10.32347179
153CAMK1D0.32273131
154PRKCZ0.31353110
155MAPK100.30941530
156PRKCD0.30058484
157RPS6KA20.30032899
158SGK30.29244725
159MAPK120.28576984
160PRKCA0.28437152
161PRKG20.26572184
162MAPK30.25573171
163ABL10.22244130
164RPS6KB20.21799090

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.93977419
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36783892
3Olfactory transduction_Homo sapiens_hsa047403.16238050
4Other glycan degradation_Homo sapiens_hsa005113.16111788
5Circadian entrainment_Homo sapiens_hsa047132.95730394
6Allograft rejection_Homo sapiens_hsa053302.90533204
7Long-term potentiation_Homo sapiens_hsa047202.87696237
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80510230
9Graft-versus-host disease_Homo sapiens_hsa053322.79270730
10Leishmaniasis_Homo sapiens_hsa051402.78944226
11Osteoclast differentiation_Homo sapiens_hsa043802.78736399
12Morphine addiction_Homo sapiens_hsa050322.77735407
13Glutamatergic synapse_Homo sapiens_hsa047242.72637244
14GABAergic synapse_Homo sapiens_hsa047272.71901970
15Amphetamine addiction_Homo sapiens_hsa050312.70844365
16Lysosome_Homo sapiens_hsa041422.52051910
17Primary immunodeficiency_Homo sapiens_hsa053402.48862496
18Autoimmune thyroid disease_Homo sapiens_hsa053202.47820001
19Staphylococcus aureus infection_Homo sapiens_hsa051502.26989226
20Dopaminergic synapse_Homo sapiens_hsa047282.21364842
21Asthma_Homo sapiens_hsa053102.21325081
22Salivary secretion_Homo sapiens_hsa049702.21065570
23Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19769017
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12695858
25Antigen processing and presentation_Homo sapiens_hsa046122.08432185
26NOD-like receptor signaling pathway_Homo sapiens_hsa046212.07058204
27NF-kappa B signaling pathway_Homo sapiens_hsa040642.04848750
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99700186
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.99569354
30Cholinergic synapse_Homo sapiens_hsa047251.98315597
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.97767720
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97385126
33Gastric acid secretion_Homo sapiens_hsa049711.92137416
34Insulin secretion_Homo sapiens_hsa049111.88974538
35Cocaine addiction_Homo sapiens_hsa050301.85961953
36Calcium signaling pathway_Homo sapiens_hsa040201.80917605
37Oxytocin signaling pathway_Homo sapiens_hsa049211.75939913
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.75567760
39Taste transduction_Homo sapiens_hsa047421.74804230
40Hematopoietic cell lineage_Homo sapiens_hsa046401.69741650
41Long-term depression_Homo sapiens_hsa047301.69694041
42Renin secretion_Homo sapiens_hsa049241.65695864
43Serotonergic synapse_Homo sapiens_hsa047261.64829203
44Malaria_Homo sapiens_hsa051441.61677588
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60885609
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56741611
47Collecting duct acid secretion_Homo sapiens_hsa049661.50231149
48GnRH signaling pathway_Homo sapiens_hsa049121.49316431
49Legionellosis_Homo sapiens_hsa051341.41313258
50TNF signaling pathway_Homo sapiens_hsa046681.41022593
51Pertussis_Homo sapiens_hsa051331.40629182
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39811732
53cAMP signaling pathway_Homo sapiens_hsa040241.37641252
54Acute myeloid leukemia_Homo sapiens_hsa052211.37176515
55Herpes simplex infection_Homo sapiens_hsa051681.34227932
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33419062
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30487938
58Measles_Homo sapiens_hsa051621.27490171
59Viral myocarditis_Homo sapiens_hsa054161.25183100
60Gap junction_Homo sapiens_hsa045401.21974805
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21110250
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19973522
63Toxoplasmosis_Homo sapiens_hsa051451.17780819
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17493327
65Phagosome_Homo sapiens_hsa041451.16730919
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13608128
67Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12275218
68Influenza A_Homo sapiens_hsa051641.10010750
69Glioma_Homo sapiens_hsa052141.09472587
70Jak-STAT signaling pathway_Homo sapiens_hsa046301.06373093
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03035065
72Estrogen signaling pathway_Homo sapiens_hsa049151.01689869
73Type II diabetes mellitus_Homo sapiens_hsa049301.01099998
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97567211
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94079234
76Vibrio cholerae infection_Homo sapiens_hsa051100.93557480
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.91879343
78Melanogenesis_Homo sapiens_hsa049160.90864648
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.90364881
80ErbB signaling pathway_Homo sapiens_hsa040120.90126048
81Shigellosis_Homo sapiens_hsa051310.84544945
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82119771
83Cardiac muscle contraction_Homo sapiens_hsa042600.80762757
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78420536
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75174756
86Axon guidance_Homo sapiens_hsa043600.74402839
87Pancreatic secretion_Homo sapiens_hsa049720.74158163
88Oocyte meiosis_Homo sapiens_hsa041140.73896734
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72868094
90Type I diabetes mellitus_Homo sapiens_hsa049400.71497932
91Hepatitis B_Homo sapiens_hsa051610.71016715
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70952479
93VEGF signaling pathway_Homo sapiens_hsa043700.70788497
94Thyroid hormone synthesis_Homo sapiens_hsa049180.69400293
95MAPK signaling pathway_Homo sapiens_hsa040100.68240719
96Apoptosis_Homo sapiens_hsa042100.66885550
97Choline metabolism in cancer_Homo sapiens_hsa052310.65861393
98Phototransduction_Homo sapiens_hsa047440.65620656
99Hepatitis C_Homo sapiens_hsa051600.64898118
100Alcoholism_Homo sapiens_hsa050340.62506963
101* Neurotrophin signaling pathway_Homo sapiens_hsa047220.61852597
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.61416478
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61151740
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60303234
105African trypanosomiasis_Homo sapiens_hsa051430.58504052
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58289739
107Epstein-Barr virus infection_Homo sapiens_hsa051690.58153536
108Chemokine signaling pathway_Homo sapiens_hsa040620.58048032
109Rap1 signaling pathway_Homo sapiens_hsa040150.57230150
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.55850786
111Renin-angiotensin system_Homo sapiens_hsa046140.54582103
112Non-small cell lung cancer_Homo sapiens_hsa052230.53844001
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.53789075
114Dilated cardiomyopathy_Homo sapiens_hsa054140.53014949
115Ras signaling pathway_Homo sapiens_hsa040140.52880725
116HTLV-I infection_Homo sapiens_hsa051660.52546579
117Nitrogen metabolism_Homo sapiens_hsa009100.51777871
118Dorso-ventral axis formation_Homo sapiens_hsa043200.51259372
119Platelet activation_Homo sapiens_hsa046110.51141157
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50967281
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49682406
122Inositol phosphate metabolism_Homo sapiens_hsa005620.49089654
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48864328
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46524932
125Endocytosis_Homo sapiens_hsa041440.46128633
126Prolactin signaling pathway_Homo sapiens_hsa049170.45273821
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.43736360
128B cell receptor signaling pathway_Homo sapiens_hsa046620.41830358
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39937538
130mTOR signaling pathway_Homo sapiens_hsa041500.39775962
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39422882
132Glucagon signaling pathway_Homo sapiens_hsa049220.39202659
133Alzheimers disease_Homo sapiens_hsa050100.38971431
134Circadian rhythm_Homo sapiens_hsa047100.36276476
135Prion diseases_Homo sapiens_hsa050200.35686024
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35091874
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33685860
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33017626
139Rheumatoid arthritis_Homo sapiens_hsa053230.32717158
140Chronic myeloid leukemia_Homo sapiens_hsa052200.32714905
141Pancreatic cancer_Homo sapiens_hsa052120.30718500
142Base excision repair_Homo sapiens_hsa034100.28677353
143T cell receptor signaling pathway_Homo sapiens_hsa046600.28600061
144Arachidonic acid metabolism_Homo sapiens_hsa005900.28583099
145Tuberculosis_Homo sapiens_hsa051520.27905174
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25366918
147Viral carcinogenesis_Homo sapiens_hsa052030.24741969
148Ether lipid metabolism_Homo sapiens_hsa005650.23831879
149Ovarian steroidogenesis_Homo sapiens_hsa049130.23650861
150Bladder cancer_Homo sapiens_hsa052190.23647031
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23256467
152Wnt signaling pathway_Homo sapiens_hsa043100.23129452
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22521557
154Salmonella infection_Homo sapiens_hsa051320.22312082
155Pentose phosphate pathway_Homo sapiens_hsa000300.22134614
156Sphingolipid metabolism_Homo sapiens_hsa006000.21731790
157Ribosome_Homo sapiens_hsa030100.21652984
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20176720
159Amoebiasis_Homo sapiens_hsa051460.17005279
160Systemic lupus erythematosus_Homo sapiens_hsa053220.16916052
161AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15077054

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