MATN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.37793608
2collagen fibril organization (GO:0030199)5.14997082
3extracellular fibril organization (GO:0043206)4.55818561
4sequestering of extracellular ligand from receptor (GO:0035581)3.95326966
5bone trabecula formation (GO:0060346)3.92883159
6collagen catabolic process (GO:0030574)3.90639434
7collagen metabolic process (GO:0032963)3.85879116
8myelination in peripheral nervous system (GO:0022011)3.77112805
9peripheral nervous system axon ensheathment (GO:0032292)3.77112805
10desmosome organization (GO:0002934)3.72541642
11keratan sulfate catabolic process (GO:0042340)3.71943063
12multicellular organismal macromolecule metabolic process (GO:0044259)3.66583902
13fibril organization (GO:0097435)3.66396667
14chondrocyte proliferation (GO:0035988)3.63759337
15multicellular organismal catabolic process (GO:0044243)3.57861404
16angiotensin maturation (GO:0002003)3.53905271
17dermatan sulfate biosynthetic process (GO:0030208)3.52390406
18multicellular organismal metabolic process (GO:0044236)3.47278892
19blood vessel maturation (GO:0001955)3.45115734
20extracellular matrix assembly (GO:0085029)3.40801884
21peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.38544870
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.35941418
23regulation of cardioblast differentiation (GO:0051890)3.33575609
24endodermal cell differentiation (GO:0035987)3.30328146
25plasma membrane repair (GO:0001778)3.27576637
26extracellular matrix disassembly (GO:0022617)3.23207738
27hemidesmosome assembly (GO:0031581)3.20270529
28dermatan sulfate metabolic process (GO:0030205)3.16819798
29regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.16537164
30bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14642121
31virion attachment to host cell (GO:0019062)3.14257947
32adhesion of symbiont to host cell (GO:0044650)3.14257947
33protein targeting to plasma membrane (GO:0072661)3.13593941
34regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.11423765
35tooth mineralization (GO:0034505)3.11200522
36epithelial cell-cell adhesion (GO:0090136)3.04508603
37NADH metabolic process (GO:0006734)3.01740482
38negative regulation of catenin import into nucleus (GO:0035414)2.95770953
39skin morphogenesis (GO:0043589)2.90247714
40basement membrane organization (GO:0071711)2.89727981
41regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88594298
42adhesion of symbiont to host (GO:0044406)2.86482100
43chondrocyte development (GO:0002063)2.82389684
44mesenchymal-epithelial cell signaling (GO:0060638)2.82380978
45neuron projection extension involved in neuron projection guidance (GO:1902284)2.80476813
46axon extension involved in axon guidance (GO:0048846)2.80476813
47regulation of transforming growth factor beta2 production (GO:0032909)2.78226732
48insulin-like growth factor receptor signaling pathway (GO:0048009)2.77715823
49endocrine hormone secretion (GO:0060986)2.72977084
50negative regulation of protein localization to cell surface (GO:2000009)2.72783936
51cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.70279871
52metanephric mesenchyme development (GO:0072075)2.69963710
53thyroid hormone generation (GO:0006590)2.69830614
54vascular endothelial growth factor signaling pathway (GO:0038084)2.69272245
55cGMP-mediated signaling (GO:0019934)2.68854346
56extracellular matrix organization (GO:0030198)2.68836179
57retina vasculature morphogenesis in camera-type eye (GO:0061299)2.68110700
58extracellular structure organization (GO:0043062)2.67463283
59atrioventricular valve morphogenesis (GO:0003181)2.66889023
60lung lobe morphogenesis (GO:0060463)2.63577090
61cell migration involved in heart development (GO:0060973)2.62758526
62negative regulation of chondrocyte differentiation (GO:0032331)2.58210754
63inner ear receptor cell development (GO:0060119)2.57250683
64craniofacial suture morphogenesis (GO:0097094)2.56715295
65trabecula formation (GO:0060343)2.55468231
66renal system process involved in regulation of blood volume (GO:0001977)2.55281849
67COPI coating of Golgi vesicle (GO:0048205)2.54526993
68Golgi transport vesicle coating (GO:0048200)2.54526993
69endocardial cushion development (GO:0003197)2.54165663
70epoxygenase P450 pathway (GO:0019373)2.53410636
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.46188774
72endocrine process (GO:0050886)2.45095737
73regulation of systemic arterial blood pressure by hormone (GO:0001990)2.45095737
74regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.45095737
75cell-substrate junction assembly (GO:0007044)2.44847066
76kidney mesenchyme development (GO:0072074)2.44683197
77regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44011585
78cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.43444125
79regulation of extracellular matrix disassembly (GO:0010715)2.41387958
80regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.41360688
81extracellular negative regulation of signal transduction (GO:1900116)2.40578763
82extracellular regulation of signal transduction (GO:1900115)2.40578763
83axon ensheathment (GO:0008366)2.39827104
84ensheathment of neurons (GO:0007272)2.39827104
85glomerular filtration (GO:0003094)2.38273971
86regulation of pseudopodium assembly (GO:0031272)2.37810999
87glomerular basement membrane development (GO:0032836)2.37303053
88thyroid hormone metabolic process (GO:0042403)2.37150996
89positive regulation of pseudopodium assembly (GO:0031274)2.36991297
90regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.36247090
91stress fiber assembly (GO:0043149)2.35876460
92metanephric epithelium development (GO:0072207)2.32320898
93regulation of dendritic spine morphogenesis (GO:0061001)2.32043284
94metanephric nephron tubule development (GO:0072234)2.31102462
95metanephric tubule development (GO:0072170)2.31102462
96positive regulation of osteoblast proliferation (GO:0033690)2.30946296
97metanephric nephron epithelium development (GO:0072243)2.30921139
98regulation of establishment of planar polarity (GO:0090175)2.30666058
99cardiac myofibril assembly (GO:0055003)2.30383537
100lipoprotein transport (GO:0042953)2.30354480
101cellular response to amino acid stimulus (GO:0071230)2.30149518
102outer ear morphogenesis (GO:0042473)2.29238748
103response to follicle-stimulating hormone (GO:0032354)2.29219503
104innervation (GO:0060384)2.29121550
105renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.28303295
106gap junction assembly (GO:0016264)2.27591346
107planar cell polarity pathway involved in neural tube closure (GO:0090179)2.27514971
108negative regulation of cartilage development (GO:0061037)2.27431946
109protein retention in ER lumen (GO:0006621)2.27241469
110hormone catabolic process (GO:0042447)2.26977310
111myelination (GO:0042552)2.26855704
112positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.26086581
113positive regulation of glycogen biosynthetic process (GO:0045725)2.25150817
114pathway-restricted SMAD protein phosphorylation (GO:0060389)2.23408773
115regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.23187210
116gonadal mesoderm development (GO:0007506)2.22143163
117positive regulation of nitric-oxide synthase activity (GO:0051000)2.21677853
118outflow tract septum morphogenesis (GO:0003148)2.21633957
119positive regulation of fatty acid beta-oxidation (GO:0032000)2.21596808
120actin filament depolymerization (GO:0030042)2.21365277
121negative regulation of complement activation (GO:0045916)2.20408373
122intestinal absorption (GO:0050892)2.19881210
123peptidyl-proline hydroxylation (GO:0019511)2.19601266
124positive regulation of endothelial cell apoptotic process (GO:2000353)2.19030738
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.18120809
126regulation of pigment cell differentiation (GO:0050932)2.17362199
127protein localization to cell surface (GO:0034394)2.16720680
128cGMP biosynthetic process (GO:0006182)2.16658882
129adherens junction assembly (GO:0034333)2.16568425
130regulation of protein localization to cell surface (GO:2000008)2.16389717
131regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.15270969
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.14774164
133* glial cell migration (GO:0008347)2.14664993
134prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.14398643
135regulation of glucose import in response to insulin stimulus (GO:2001273)2.13892105
136macroautophagy (GO:0016236)2.13466937
137cell adhesion mediated by integrin (GO:0033627)2.13254829
138renal filtration (GO:0097205)2.12760748
139negative regulation of fatty acid transport (GO:2000192)2.12559976
140positive regulation of mesenchymal cell proliferation (GO:0002053)2.12424854
141cell-matrix adhesion (GO:0007160)2.12260462
142coronary vasculature morphogenesis (GO:0060977)2.11662232
143mesonephros development (GO:0001823)2.11564120
144sulfate transmembrane transport (GO:1902358)2.11308020
145barbed-end actin filament capping (GO:0051016)2.11269693
146axonal fasciculation (GO:0007413)2.10968616
147cellular response to vitamin (GO:0071295)2.10683343
148endothelial cell chemotaxis (GO:0035767)2.09903531
149regulation of p38MAPK cascade (GO:1900744)2.09211365
150midgut development (GO:0007494)2.09049635
151regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.08988961
152endothelial cell morphogenesis (GO:0001886)2.08885191
153dendritic spine organization (GO:0097061)2.08867996
154fat-soluble vitamin biosynthetic process (GO:0042362)2.08843627
155regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.08801064
156positive regulation of fibroblast migration (GO:0010763)2.07240392
157embryonic cranial skeleton morphogenesis (GO:0048701)2.07151491
158apoptotic cell clearance (GO:0043277)2.07091076
159ER overload response (GO:0006983)2.06562065
160myelin maintenance (GO:0043217)2.05301669
161branching involved in prostate gland morphogenesis (GO:0060442)2.05292871
162negative regulation of BMP signaling pathway (GO:0030514)2.04905055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.71156789
2EZH2_22144423_ChIP-Seq_EOC_Human2.98252577
3GBX2_23144817_ChIP-Seq_PC3_Human2.71028451
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69662607
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52145413
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52145413
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.51607237
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.49348963
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46768272
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.45077219
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42951524
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39188510
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24887933
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19578355
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16439982
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08223405
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07263654
18AR_21572438_ChIP-Seq_LNCaP_Human2.07093145
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01092679
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00823932
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.00476566
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.99381910
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.89572695
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86565271
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.83385718
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.81633307
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81534361
28CJUN_26792858_Chip-Seq_BT549_Human1.76975233
29* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75884358
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.74136603
31TP53_16413492_ChIP-PET_HCT116_Human1.73892851
32* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.73431671
33* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.73431671
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.72915064
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71785453
36TP53_18474530_ChIP-ChIP_U2OS_Human1.68041709
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67683845
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67211116
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60931878
40CLOCK_20551151_ChIP-Seq_293T_Human1.60675094
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57576313
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.55793533
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.54621157
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54303992
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.54095714
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.54095714
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54019666
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53233965
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52535402
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49987652
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.49431169
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.48407871
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48100328
54* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46925557
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44297597
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44214736
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43548131
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.41181181
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39419242
60DROSHA_22980978_ChIP-Seq_HELA_Human1.38776237
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36342783
62SMAD4_21799915_ChIP-Seq_A2780_Human1.34722630
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32917049
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31336568
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29927422
66AHR_22903824_ChIP-Seq_MCF-7_Human1.29518346
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29302480
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29058531
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.26339352
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.22587758
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.22578658
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21292187
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18412170
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17843413
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17536577
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.17173226
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16887652
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16378257
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16193706
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15944453
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.15323078
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14065543
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13851369
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.13724382
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13541529
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13421366
87* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13335315
88* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11424032
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11029192
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09716971
91BCAT_22108803_ChIP-Seq_LS180_Human1.09424833
92P300_19829295_ChIP-Seq_ESCs_Human1.08661656
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08001077
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.07989987
95* BRD4_25478319_ChIP-Seq_HGPS_Human1.07521199
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.07288293
97RACK7_27058665_Chip-Seq_MCF-7_Human1.07025859
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.05329217
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03822700
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03557975
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.02664386
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02616072
103P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02511221
104RXR_22108803_ChIP-Seq_LS180_Human1.01811257
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.01285326
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.00890314
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00658142
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00658142
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00379512
110GATA4_25053715_ChIP-Seq_YYC3_Human0.99859012
111FOXA2_19822575_ChIP-Seq_HepG2_Human0.99613440
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99451251
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.98660499
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98203607
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98123205
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97684919
117ZNF274_21170338_ChIP-Seq_K562_Hela0.96984295
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.96650825
119GATA3_24758297_ChIP-Seq_MCF-7_Human0.96638506
120AR_25329375_ChIP-Seq_VCAP_Human0.96355508
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95650998
122RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95571120
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95529864
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95326576
125* SMAD3_21741376_ChIP-Seq_HESCs_Human0.94913551
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94788887
127SOX2_20726797_ChIP-Seq_SW620_Human0.92970440
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.92536635
129KLF5_25053715_ChIP-Seq_YYC3_Human0.91776441
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91648003
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.90732933
132* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90644545
133* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90360112
134ZNF263_19887448_ChIP-Seq_K562_Human0.90216194
135* AR_19668381_ChIP-Seq_PC3_Human0.89468801
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.89122733
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89031497
138SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88901108
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88211627
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87887581
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87446752
142TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87062431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.83568240
2MP0005503_abnormal_tendon_morphology5.07260211
3MP0005275_abnormal_skin_tensile4.90829362
4MP0004272_abnormal_basement_membrane3.85392746
5MP0002837_dystrophic_cardiac_calcinosis2.69294395
6MP0000751_myopathy2.69164818
7MP0001958_emphysema2.56503470
8MP0005360_urolithiasis2.45232708
9MP0009780_abnormal_chondrocyte_physiolo2.35508412
10MP0003045_fibrosis2.27896755
11MP0005623_abnormal_meninges_morphology2.26724878
12MP0003279_aneurysm2.25065451
13MP0002108_abnormal_muscle_morphology2.22376189
14MP0003705_abnormal_hypodermis_morpholog2.19699614
15MP0010368_abnormal_lymphatic_system2.10433240
16MP0005670_abnormal_white_adipose1.95358488
17MP0003941_abnormal_skin_development1.91322542
18MP0009384_cardiac_valve_regurgitation1.90641947
19MP0005409_darkened_coat_color1.87122816
20MP0000013_abnormal_adipose_tissue1.83296391
21MP0005508_abnormal_skeleton_morphology1.80974408
22MP0002060_abnormal_skin_morphology1.80461076
23MP0001299_abnormal_eye_distance/1.76898663
24MP0005171_absent_coat_pigmentation1.75959887
25MP0004264_abnormal_extraembryonic_tissu1.69371571
26MP0004859_abnormal_synaptic_plasticity1.67460112
27MP0006138_congestive_heart_failure1.57019431
28MP0009250_abnormal_appendicular_skeleto1.50386813
29MP0004858_abnormal_nervous_system1.48600544
30MP0002896_abnormal_bone_mineralization1.46923516
31MP0010234_abnormal_vibrissa_follicle1.44296897
32MP0003283_abnormal_digestive_organ1.39189951
33MP0000749_muscle_degeneration1.36410600
34MP0004134_abnormal_chest_morphology1.35340946
35MP0002168_other_aberrant_phenotype1.34907972
36MP0003385_abnormal_body_wall1.34711323
37MP0000003_abnormal_adipose_tissue1.32789942
38MP0009840_abnormal_foam_cell1.32732097
39MP0002295_abnormal_pulmonary_circulatio1.32502426
40MP0010386_abnormal_urinary_bladder1.30999883
41MP0006054_spinal_hemorrhage1.30248335
42MP0010030_abnormal_orbit_morphology1.30099453
43MP0000566_synostosis1.27104834
44MP0000534_abnormal_ureter_morphology1.24023058
45MP0000920_abnormal_myelination1.23590752
46MP0002876_abnormal_thyroid_physiology1.23510791
47MP0004019_abnormal_vitamin_homeostasis1.23157777
48MP0000579_abnormal_nail_morphology1.21420686
49MP0003868_abnormal_feces_composition1.20961393
50MP0003183_abnormal_peptide_metabolism1.20692075
51MP0004145_abnormal_muscle_electrophysio1.18523784
52MP0000538_abnormal_urinary_bladder1.17888270
53MP0001542_abnormal_bone_strength1.16269966
54MP0002796_impaired_skin_barrier1.14808690
55MP0000750_abnormal_muscle_regeneration1.14775713
56MP0000163_abnormal_cartilage_morphology1.14086465
57MP0000537_abnormal_urethra_morphology1.11145693
58MP0005666_abnormal_adipose_tissue1.10831174
59MP0009379_abnormal_foot_pigmentation1.09945296
60MP0004084_abnormal_cardiac_muscle1.08940831
61MP0002877_abnormal_melanocyte_morpholog1.07095453
62MP0000383_abnormal_hair_follicle1.06992738
63MP0001666_abnormal_nutrient_absorption1.06714889
64MP0002115_abnormal_skeleton_extremities1.04900714
65MP0010678_abnormal_skin_adnexa1.03879233
66MP0000747_muscle_weakness1.02139265
67MP0010352_gastrointestinal_tract_polyps1.01076238
68MP0005257_abnormal_intraocular_pressure1.00526354
69MP0002971_abnormal_brown_adipose0.99765642
70MP0005369_muscle_phenotype0.99501114
71MP0004484_altered_response_of0.99032305
72MP0005085_abnormal_gallbladder_physiolo0.98899870
73MP0000733_abnormal_muscle_development0.96860644
74MP0000762_abnormal_tongue_morphology0.96400338
75MP0003942_abnormal_urinary_system0.95888860
76MP0004270_analgesia0.95629856
77MP0010329_abnormal_lipoprotein_level0.94407001
78MP0003566_abnormal_cell_adhesion0.94322460
79MP0002282_abnormal_trachea_morphology0.93852772
80MP0002909_abnormal_adrenal_gland0.92895172
81MP0003329_amyloid_beta_deposits0.92145075
82MP0001661_extended_life_span0.91800299
83MP0001879_abnormal_lymphatic_vessel0.91231995
84MP0003634_abnormal_glial_cell0.90727932
85MP0005365_abnormal_bile_salt0.90246314
86MP0003950_abnormal_plasma_membrane0.90046975
87MP0003091_abnormal_cell_migration0.89807074
88MP0000516_abnormal_urinary_system0.89430229
89MP0005367_renal/urinary_system_phenotyp0.89430229
90MP0000467_abnormal_esophagus_morphology0.89132499
91MP0001243_abnormal_dermal_layer0.88107841
92MP0001756_abnormal_urination0.87779769
93MP0003880_abnormal_central_pattern0.87635505
94MP0000681_abnormal_thyroid_gland0.86231320
95MP0001664_abnormal_digestion0.86022180
96MP0000759_abnormal_skeletal_muscle0.85297448
97MP0003635_abnormal_synaptic_transmissio0.84686632
98MP0000462_abnormal_digestive_system0.84639819
99MP0005390_skeleton_phenotype0.84336657
100MP0003879_abnormal_hair_cell0.84092564
101MP0005595_abnormal_vascular_smooth0.83568795
102MP0002933_joint_inflammation0.82375417
103MP0000049_abnormal_middle_ear0.81591854
104MP0005375_adipose_tissue_phenotype0.81429363
105MP0003755_abnormal_palate_morphology0.79220222
106MP0003935_abnormal_craniofacial_develop0.77535898
107MP0000428_abnormal_craniofacial_morphol0.76039087
108MP0005620_abnormal_muscle_contractility0.75860027
109MP0002113_abnormal_skeleton_development0.74766881
110MP0009643_abnormal_urine_homeostasis0.74013484
111MP0005330_cardiomyopathy0.73541172
112MP0004087_abnormal_muscle_fiber0.73415811
113MP0002116_abnormal_craniofacial_bone0.73192241
114MP0001968_abnormal_touch/_nociception0.72296562
115MP0005023_abnormal_wound_healing0.72183310
116MP0002998_abnormal_bone_remodeling0.71806355
117MP0004043_abnormal_pH_regulation0.71773962
118MP0003122_maternal_imprinting0.71272779
119MP0000432_abnormal_head_morphology0.70765980
120MP0002106_abnormal_muscle_physiology0.70556554
121MP0010771_integument_phenotype0.70064972
122MP0005076_abnormal_cell_differentiation0.69870980
123MP0008775_abnormal_heart_ventricle0.68994626
124MP0005501_abnormal_skin_physiology0.68533321
125MP0002109_abnormal_limb_morphology0.68380049
126MP0002249_abnormal_larynx_morphology0.67922835
127MP0003115_abnormal_respiratory_system0.67907980
128MP0002133_abnormal_respiratory_system0.67777344
129MP0005388_respiratory_system_phenotype0.67777344
130MP0002972_abnormal_cardiac_muscle0.67085707
131MP0001177_atelectasis0.67027898
132MP0002234_abnormal_pharynx_morphology0.66992660
133MP0010630_abnormal_cardiac_muscle0.66606255
134MP0004233_abnormal_muscle_weight0.66496317
135MP0002063_abnormal_learning/memory/cond0.65806430
136MP0002272_abnormal_nervous_system0.65783530
137MP0000230_abnormal_systemic_arterial0.65423237
138MP0005164_abnormal_response_to0.64949772
139MP0004215_abnormal_myocardial_fiber0.64438961
140MP0002932_abnormal_joint_morphology0.63577183
141MP0004036_abnormal_muscle_relaxation0.62889615
142MP0002938_white_spotting0.61799034
143MP0004883_abnormal_blood_vessel0.60494847
144MP0004185_abnormal_adipocyte_glucose0.60374920
145MP0000767_abnormal_smooth_muscle0.60315518
146MP0001849_ear_inflammation0.60088502

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.10296951
2Premature rupture of membranes (HP:0001788)6.07429276
3Ankle contracture (HP:0006466)5.16606890
4Atrophic scars (HP:0001075)4.50326711
5Broad metatarsal (HP:0001783)4.44924402
6Aortic dissection (HP:0002647)4.42312169
7Cervical subluxation (HP:0003308)4.39690695
8Ulnar claw (HP:0001178)3.89349341
9Type 1 muscle fiber predominance (HP:0003803)3.89330391
10Soft skin (HP:0000977)3.88460163
11Follicular hyperkeratosis (HP:0007502)3.83567588
12Shallow orbits (HP:0000586)3.81339218
13Fragile skin (HP:0001030)3.74498353
14Right ventricular cardiomyopathy (HP:0011663)3.61144378
15Overgrowth (HP:0001548)3.52908395
16Cerebral aneurysm (HP:0004944)3.51646203
17Spinal rigidity (HP:0003306)3.42194921
18Segmental peripheral demyelination/remyelination (HP:0003481)3.42166848
19Insidious onset (HP:0003587)3.39580436
20Termporal pattern (HP:0011008)3.39580436
21Aortic aneurysm (HP:0004942)3.39204715
22Slender build (HP:0001533)3.35857760
23Thin bony cortex (HP:0002753)3.26072445
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.22924583
25Bladder diverticulum (HP:0000015)3.13418454
26Mildly elevated creatine phosphokinase (HP:0008180)2.99459430
27Abnormality of dentin (HP:0010299)2.98598635
28Dilatation of the ascending aorta (HP:0005111)2.90790552
29Increased variability in muscle fiber diameter (HP:0003557)2.86240026
30Increased connective tissue (HP:0009025)2.81879769
31Neonatal short-limb short stature (HP:0008921)2.80751132
32Wormian bones (HP:0002645)2.77616583
33Abnormality of proline metabolism (HP:0010907)2.75998659
34Hydroxyprolinuria (HP:0003080)2.75998659
35Hyperextensible skin (HP:0000974)2.72392783
36Mitral valve prolapse (HP:0001634)2.69292474
37Action tremor (HP:0002345)2.64731706
38Vascular tortuosity (HP:0004948)2.63187037
39Wrist flexion contracture (HP:0001239)2.60673481
40Blue sclerae (HP:0000592)2.57057656
41Upper limb muscle weakness (HP:0003484)2.53159612
42Buphthalmos (HP:0000557)2.47648021
43Mitral stenosis (HP:0001718)2.47265966
44Abnormality of skeletal muscle fiber size (HP:0012084)2.40878624
45Joint laxity (HP:0001388)2.33701936
46Pulmonary artery stenosis (HP:0004415)2.33070635
47Genu recurvatum (HP:0002816)2.32719998
48Peritonitis (HP:0002586)2.31952977
49Arterial tortuosity (HP:0005116)2.31111952
50Aortic regurgitation (HP:0001659)2.30401241
51Onion bulb formation (HP:0003383)2.28238039
52Infantile muscular hypotonia (HP:0008947)2.22813458
53Osteolytic defects of the hand bones (HP:0009699)2.21615692
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.21615692
55Malnutrition (HP:0004395)2.16929669
56Scapular winging (HP:0003691)2.15545079
57Hammertoe (HP:0001765)2.15386592
58Amelogenesis imperfecta (HP:0000705)2.14054189
59Coronal craniosynostosis (HP:0004440)2.13300387
60Hypoventilation (HP:0002791)2.09546951
61Striae distensae (HP:0001065)2.09135456
62Ulnar deviation of the wrist (HP:0003049)2.08776597
63Broad ribs (HP:0000885)2.06651647
64Breech presentation (HP:0001623)2.06493900
65Osteoarthritis (HP:0002758)2.05018987
66Bell-shaped thorax (HP:0001591)2.04390166
67Cerebral inclusion bodies (HP:0100314)2.00776161
68Ventricular tachycardia (HP:0004756)1.99400083
69Complement deficiency (HP:0004431)1.99260288
70Wide anterior fontanel (HP:0000260)1.98895861
71Tibial bowing (HP:0002982)1.95614642
72Vertebral compression fractures (HP:0002953)1.95543663
73Limb-girdle muscle weakness (HP:0003325)1.95395045
74Short nail (HP:0001799)1.94704125
75Elbow flexion contracture (HP:0002987)1.94703805
76Aneurysm (HP:0002617)1.94332485
77Lymphangioma (HP:0100764)1.93550501
78Short hallux (HP:0010109)1.93403198
79Neoplasm of the heart (HP:0100544)1.93247783
80Abnormal delivery (HP:0001787)1.92413293
81Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.90617859
82Abnormality of complement system (HP:0005339)1.89511170
83Aplasia involving bones of the extremities (HP:0009825)1.88536739
84Aplasia involving bones of the upper limbs (HP:0009823)1.88536739
85Aplasia of the phalanges of the hand (HP:0009802)1.88536739
86Congenital glaucoma (HP:0001087)1.87879774
87Distal arthrogryposis (HP:0005684)1.86192606
88Delayed closure of the anterior fontanelle (HP:0001476)1.84742920
89Flared iliac wings (HP:0002869)1.84012238
90Abnormality of the acetabulum (HP:0003170)1.83734377
91Wide cranial sutures (HP:0010537)1.82913462
92Hyporeflexia of lower limbs (HP:0002600)1.82324362
93Muscle fiber splitting (HP:0003555)1.81790337
94Narrow nasal bridge (HP:0000446)1.81254765
95Delayed epiphyseal ossification (HP:0002663)1.80685640
96Round ear (HP:0100830)1.79312381
97Hypoplastic ischia (HP:0003175)1.78213541
98Hyperparathyroidism (HP:0000843)1.78147047
99Steppage gait (HP:0003376)1.77689050
100Ectopia lentis (HP:0001083)1.77193729
101Hypoplasia of the iris (HP:0007676)1.76800700
102Difficulty climbing stairs (HP:0003551)1.76651806
103Focal segmental glomerulosclerosis (HP:0000097)1.76552650
104Trismus (HP:0000211)1.76193728
105Limited hip movement (HP:0008800)1.75827509
106Foot dorsiflexor weakness (HP:0009027)1.75445861
107Aplasia/Hypoplasia of the hallux (HP:0008362)1.75445023
108Spondylolisthesis (HP:0003302)1.75429068
109Hypoplasia of the odontoid process (HP:0003311)1.74579070
110Hip contracture (HP:0003273)1.74335626
111Cardiovascular calcification (HP:0011915)1.74019172
112Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.73727784
113Neurofibrillary tangles (HP:0002185)1.73609524
114Biconcave vertebral bodies (HP:0004586)1.72909319
115Venous abnormality (HP:0002624)1.72710402
116Abnormality of the distal phalanx of the thumb (HP:0009617)1.72638463
117Absent frontal sinuses (HP:0002688)1.70437235
118Broad face (HP:0000283)1.70393032
119Alopecia of scalp (HP:0002293)1.70261286
120Deviation of the hallux (HP:0010051)1.69605629
121Gingival overgrowth (HP:0000212)1.69428303
122Bowel diverticulosis (HP:0005222)1.68727139
123Systemic lupus erythematosus (HP:0002725)1.68219447
124Inguinal hernia (HP:0000023)1.67171870
125Flat acetabular roof (HP:0003180)1.67136115
126Venous insufficiency (HP:0005293)1.66566713
127Abnormality of calcium-phosphate metabolism (HP:0100530)1.66471497
128Ulnar bowing (HP:0003031)1.65935695
129Asymmetric septal hypertrophy (HP:0001670)1.64894474
130Abnormality of the calf musculature (HP:0001430)1.64120588
131Rectal prolapse (HP:0002035)1.63890062
132Mitral regurgitation (HP:0001653)1.63564802
133Abdominal distention (HP:0003270)1.63285996
134Asymmetry of the thorax (HP:0001555)1.63001026
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62700069
136Bronchomalacia (HP:0002780)1.62074899
137Long toe (HP:0010511)1.61770483
138Bradycardia (HP:0001662)1.61378747
139Turricephaly (HP:0000262)1.60550919
140Femoral bowing (HP:0002980)1.58610094
141Acanthosis nigricans (HP:0000956)1.58124797
142Congenital sensorineural hearing impairment (HP:0008527)1.58105410
143Lipoatrophy (HP:0100578)1.57650337
144Aortic valve stenosis (HP:0001650)1.57387912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.00043087
2PRKD33.18563776
3TTN2.80359934
4EPHA42.79459414
5PDGFRA2.61293230
6EPHA22.41031755
7NTRK32.39894129
8NTRK12.20404258
9PTK2B2.18847222
10FER2.12235706
11FRK2.10949301
12PLK22.07837668
13LATS12.06865157
14EEF2K2.00328698
15SIK11.99481535
16DMPK1.98245411
17PKN21.96415331
18FGFR21.79084234
19LATS21.71325821
20TRIB31.68655530
21MYLK1.66545288
22MET1.64892299
23EPHB11.62636357
24TESK11.58290715
25MAPKAPK31.57474385
26FGFR41.55621706
27MAP3K41.44667153
28MAP3K61.40225802
29MAP3K21.39444306
30RET1.35235157
31CAMK1G1.30700299
32STK38L1.29940526
33CCNB11.28550422
34STK391.27069108
35ROCK21.26516366
36TRPM71.25261021
37PAK21.24892925
38PTK21.22678137
39TIE11.21723084
40PDGFRB1.19428612
41PAK31.19257987
42CAMK1D1.18474551
43PIK3CA1.16085882
44ACVR1B1.15587598
45NEK91.14063780
46KSR21.13508962
47MAP2K21.12153982
48MAP3K121.11533931
49PAK61.08179082
50CAMK2G1.07526817
51MOS1.06274850
52EPHA31.06058272
53PAK41.04888690
54INSRR1.03865916
55ROCK11.03566328
56MAP2K11.02133773
57PRKG20.99709507
58STK380.99498985
59EPHB20.99089739
60ICK0.98929836
61BMX0.98358067
62RIPK40.96903674
63PRKCE0.95720241
64PRKCH0.95170330
65MAP2K70.91243209
66LMTK20.90619052
67PRKAA20.87252014
68MAP2K40.86519705
69MAP3K30.86471828
70ERN10.83655187
71BMPR20.83430328
72CAMK2D0.83227791
73ILK0.82423788
74CAMK2B0.82014783
75NUAK10.81774325
76CAMK2A0.79559087
77WNK40.79350484
78NME10.78842619
79SGK2230.78686268
80SGK4940.78686268
81RIPK10.76800918
82NEK60.76467042
83TGFBR20.75545017
84MARK20.72397720
85MINK10.72388104
86CDK50.72076412
87FGFR10.71464426
88PRKD20.70678754
89MAPKAPK50.70240249
90RPS6KL10.70045297
91RPS6KC10.70045297
92PRKD10.69311036
93FGR0.68448385
94GRK50.67960408
95WNK10.66757174
96LIMK10.66716571
97RPS6KB20.65937546
98MST1R0.65874109
99KSR10.65522098
100PIK3CG0.63516465
101PTK60.60417571
102NLK0.59756639
103GSK3A0.59571825
104PDK20.58284268
105INSR0.58034239
106CAMKK20.56616879
107CASK0.55346875
108RPS6KA60.55156478
109FGFR30.54946752
110TYRO30.54262444
111AKT30.52968827
112MAPK40.52516405
113SMG10.51286384
114DYRK1A0.50886172
115RPS6KA20.50383573
116ERBB20.48590974
117PRKCG0.48245346
118MAPK120.47320939
119SRC0.46541894
120MAPK70.45792688
121DAPK30.45118689
122IRAK20.44782195
123ARAF0.44543544
124MAP3K70.43455479
125CDC42BPA0.43234734
126ADRBK10.42646350
127MAPKAPK20.42477083
128STK30.42147650
129JAK10.42127781
130CAMKK10.42081033
131ABL20.40804575
132PRKAA10.40459327
133IRAK10.40038344
134FYN0.38737064
135PDPK10.38673541
136AKT20.38256493
137MTOR0.37779428
138ERBB40.37557076
139PRKACG0.31985965
140CDK60.30049118
141SGK30.27888361

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.26252162
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.53824113
3Renin-angiotensin system_Homo sapiens_hsa046142.35341082
4Histidine metabolism_Homo sapiens_hsa003402.14437689
5Focal adhesion_Homo sapiens_hsa045102.10502398
6Vitamin digestion and absorption_Homo sapiens_hsa049772.08348515
7Protein digestion and absorption_Homo sapiens_hsa049742.06774075
8PPAR signaling pathway_Homo sapiens_hsa033201.96656656
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93791587
10Dilated cardiomyopathy_Homo sapiens_hsa054141.91674357
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91083579
12Fat digestion and absorption_Homo sapiens_hsa049751.90968869
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.76227079
14Long-term potentiation_Homo sapiens_hsa047201.73558155
15Bile secretion_Homo sapiens_hsa049761.68877291
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67270442
17Circadian entrainment_Homo sapiens_hsa047131.57960028
18Renin secretion_Homo sapiens_hsa049241.56030972
19Amoebiasis_Homo sapiens_hsa051461.54549442
20Amphetamine addiction_Homo sapiens_hsa050311.52022726
21Salivary secretion_Homo sapiens_hsa049701.42972349
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42404552
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40327763
24Axon guidance_Homo sapiens_hsa043601.39870056
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37588589
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37010850
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35543614
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34184577
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34180234
30Gastric acid secretion_Homo sapiens_hsa049711.34050473
31Insulin secretion_Homo sapiens_hsa049111.33342926
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33233602
33Glioma_Homo sapiens_hsa052141.31879405
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29151761
35Mineral absorption_Homo sapiens_hsa049781.26951936
36Proteoglycans in cancer_Homo sapiens_hsa052051.26904703
37Phenylalanine metabolism_Homo sapiens_hsa003601.25440397
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25013374
39Dopaminergic synapse_Homo sapiens_hsa047281.23914251
40Retinol metabolism_Homo sapiens_hsa008301.23875203
41Hedgehog signaling pathway_Homo sapiens_hsa043401.23126265
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.22745271
43Nicotine addiction_Homo sapiens_hsa050331.21998569
44Oxytocin signaling pathway_Homo sapiens_hsa049211.21780590
45Starch and sucrose metabolism_Homo sapiens_hsa005001.20130491
46Melanogenesis_Homo sapiens_hsa049161.19396642
47Gap junction_Homo sapiens_hsa045401.18979068
48Adherens junction_Homo sapiens_hsa045201.18711422
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18430684
50Fatty acid degradation_Homo sapiens_hsa000711.17923287
51Arginine biosynthesis_Homo sapiens_hsa002201.17793727
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16998151
53Estrogen signaling pathway_Homo sapiens_hsa049151.16662245
54Galactose metabolism_Homo sapiens_hsa000521.16485656
55Glutamatergic synapse_Homo sapiens_hsa047241.16261977
56GnRH signaling pathway_Homo sapiens_hsa049121.15444999
57Long-term depression_Homo sapiens_hsa047301.14153055
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13994915
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13981955
60Cholinergic synapse_Homo sapiens_hsa047251.13790492
61Tyrosine metabolism_Homo sapiens_hsa003501.11893930
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11832421
63Chemical carcinogenesis_Homo sapiens_hsa052041.11174270
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.08026634
65Arginine and proline metabolism_Homo sapiens_hsa003301.07921078
66Thyroid hormone synthesis_Homo sapiens_hsa049181.07825732
67Calcium signaling pathway_Homo sapiens_hsa040201.06848008
68Wnt signaling pathway_Homo sapiens_hsa043101.06592231
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06377746
70Tryptophan metabolism_Homo sapiens_hsa003801.04650102
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03315405
72Vibrio cholerae infection_Homo sapiens_hsa051101.02596019
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02244706
74PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00214299
75Glycerolipid metabolism_Homo sapiens_hsa005610.99602636
76Taste transduction_Homo sapiens_hsa047420.99384081
77cAMP signaling pathway_Homo sapiens_hsa040240.98872782
78Caffeine metabolism_Homo sapiens_hsa002320.96823192
79Sulfur metabolism_Homo sapiens_hsa009200.95470336
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94966112
81GABAergic synapse_Homo sapiens_hsa047270.92227468
82Fructose and mannose metabolism_Homo sapiens_hsa000510.92123238
83Morphine addiction_Homo sapiens_hsa050320.91433553
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91283515
85TGF-beta signaling pathway_Homo sapiens_hsa043500.91150158
86Serotonergic synapse_Homo sapiens_hsa047260.90710968
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86820801
88Type II diabetes mellitus_Homo sapiens_hsa049300.86281133
89Melanoma_Homo sapiens_hsa052180.85538059
90Cocaine addiction_Homo sapiens_hsa050300.84620079
91Hippo signaling pathway_Homo sapiens_hsa043900.84070087
92AMPK signaling pathway_Homo sapiens_hsa041520.83673099
93Sphingolipid metabolism_Homo sapiens_hsa006000.83401549
94Linoleic acid metabolism_Homo sapiens_hsa005910.82749426
95Basal cell carcinoma_Homo sapiens_hsa052170.82201019
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80710755
97Rap1 signaling pathway_Homo sapiens_hsa040150.79859811
98Prion diseases_Homo sapiens_hsa050200.77579570
99Other glycan degradation_Homo sapiens_hsa005110.77260653
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76669888
101Ras signaling pathway_Homo sapiens_hsa040140.76598609
102ErbB signaling pathway_Homo sapiens_hsa040120.76597433
103Arachidonic acid metabolism_Homo sapiens_hsa005900.75354400
104Olfactory transduction_Homo sapiens_hsa047400.74454804
105Tight junction_Homo sapiens_hsa045300.73744864
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72368988
107Complement and coagulation cascades_Homo sapiens_hsa046100.72098554
108Pancreatic secretion_Homo sapiens_hsa049720.72034189
109Bladder cancer_Homo sapiens_hsa052190.71784971
110Prostate cancer_Homo sapiens_hsa052150.71354440
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69819078
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.68589150
113Fatty acid metabolism_Homo sapiens_hsa012120.68579858
114Dorso-ventral axis formation_Homo sapiens_hsa043200.68467027
115Viral myocarditis_Homo sapiens_hsa054160.67936511
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.67267299
117Small cell lung cancer_Homo sapiens_hsa052220.66619818
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66488421
119beta-Alanine metabolism_Homo sapiens_hsa004100.65207798
120Glucagon signaling pathway_Homo sapiens_hsa049220.62312608
121Platelet activation_Homo sapiens_hsa046110.61818276
122MicroRNAs in cancer_Homo sapiens_hsa052060.61160967
123Thyroid cancer_Homo sapiens_hsa052160.61018076
124Ovarian steroidogenesis_Homo sapiens_hsa049130.60604711
125Choline metabolism in cancer_Homo sapiens_hsa052310.60561520
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.60191807
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.59739379
128Insulin resistance_Homo sapiens_hsa049310.59127538
129Pathways in cancer_Homo sapiens_hsa052000.58127711
130Synaptic vesicle cycle_Homo sapiens_hsa047210.58095421
131Phagosome_Homo sapiens_hsa041450.58023345
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56140025
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55003080
134VEGF signaling pathway_Homo sapiens_hsa043700.54756049
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.53953672
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53737659
137Renal cell carcinoma_Homo sapiens_hsa052110.52927737
138Notch signaling pathway_Homo sapiens_hsa043300.52060481
139MAPK signaling pathway_Homo sapiens_hsa040100.51431586
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.50706090
141Collecting duct acid secretion_Homo sapiens_hsa049660.50289196
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50093414
143Endometrial cancer_Homo sapiens_hsa052130.50014716
144Lysosome_Homo sapiens_hsa041420.49549564
145Insulin signaling pathway_Homo sapiens_hsa049100.49092069
146Malaria_Homo sapiens_hsa051440.48909897
147Protein export_Homo sapiens_hsa030600.48851766
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48600146
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.48588871
150Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47367284
151Fatty acid elongation_Homo sapiens_hsa000620.47231260
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47130684

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