MATR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)8.12722850
2piRNA metabolic process (GO:0034587)7.95395644
3chromosome organization involved in meiosis (GO:0070192)6.67074496
4regulation of meiosis I (GO:0060631)6.47728085
5male meiosis I (GO:0007141)6.38523601
6DNA methylation involved in gamete generation (GO:0043046)6.11933769
7mitotic sister chromatid cohesion (GO:0007064)5.97685374
8synaptonemal complex assembly (GO:0007130)5.91155333
9DNA synthesis involved in DNA repair (GO:0000731)5.87977003
10male meiosis (GO:0007140)5.75219521
11synaptonemal complex organization (GO:0070193)5.35883551
12sister chromatid cohesion (GO:0007062)5.21276013
13meiosis I (GO:0007127)5.11993301
14positive regulation of male gonad development (GO:2000020)5.07681665
15meiotic nuclear division (GO:0007126)4.94686886
16neuron cell-cell adhesion (GO:0007158)4.83842065
17meiotic chromosome segregation (GO:0045132)4.70628124
18vocalization behavior (GO:0071625)4.49824125
19regulation of DNA endoreduplication (GO:0032875)4.48810053
20regulation of short-term neuronal synaptic plasticity (GO:0048172)4.46081151
21resolution of meiotic recombination intermediates (GO:0000712)4.45300837
22protein localization to synapse (GO:0035418)4.41573724
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.41270121
24meiotic cell cycle process (GO:1903046)4.25017309
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.11101231
26synaptic vesicle exocytosis (GO:0016079)4.09077259
27regulation of male gonad development (GO:2000018)4.08288102
28reciprocal DNA recombination (GO:0035825)4.03410913
29reciprocal meiotic recombination (GO:0007131)4.03410913
30presynaptic membrane assembly (GO:0097105)3.97594816
31regulation of glutamate receptor signaling pathway (GO:1900449)3.90484748
32positive regulation of meiosis (GO:0045836)3.86669739
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86175129
34neuron recognition (GO:0008038)3.81941585
35sex differentiation (GO:0007548)3.79144018
36layer formation in cerebral cortex (GO:0021819)3.76264774
37nuclear pore complex assembly (GO:0051292)3.76180550
38regulation of synaptic vesicle exocytosis (GO:2000300)3.76138704
39gene silencing by RNA (GO:0031047)3.73951154
40embryonic foregut morphogenesis (GO:0048617)3.73943324
41presynaptic membrane organization (GO:0097090)3.72856781
42positive regulation of synapse maturation (GO:0090129)3.68623568
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.65223046
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.64979479
45nuclear pore organization (GO:0006999)3.64035863
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.63920114
47postsynaptic membrane organization (GO:0001941)3.61249017
48axonal fasciculation (GO:0007413)3.61224754
49histone H3-K9 demethylation (GO:0033169)3.58181625
50positive regulation of meiotic cell cycle (GO:0051446)3.57448263
51synaptic transmission, glutamatergic (GO:0035249)3.55332531
52neuron-neuron synaptic transmission (GO:0007270)3.53363770
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51914482
54mitotic chromosome condensation (GO:0007076)3.51908520
55glutamate receptor signaling pathway (GO:0007215)3.50362254
56neurotransmitter-gated ion channel clustering (GO:0072578)3.50089643
57glutamate secretion (GO:0014047)3.48175209
58locomotory exploration behavior (GO:0035641)3.45064604
59regulation of transcription from RNA polymerase I promoter (GO:0006356)3.40332330
60dendritic spine morphogenesis (GO:0060997)3.37498920
61protein localization to chromosome (GO:0034502)3.36989244
62regulation of synapse maturation (GO:0090128)3.36011328
63negative regulation of meiosis (GO:0045835)3.35525722
64synaptic vesicle maturation (GO:0016188)3.35228621
65exploration behavior (GO:0035640)3.30084646
66histone H2A acetylation (GO:0043968)3.29532740
67regulation of synaptic vesicle transport (GO:1902803)3.24741042
68neurotransmitter secretion (GO:0007269)3.19303110
69positive regulation of dendritic spine morphogenesis (GO:0061003)3.19017222
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.18911104
71regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17637633
72negative regulation of DNA-dependent DNA replication (GO:2000104)3.16553088
73positive regulation of synapse assembly (GO:0051965)3.16250388
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10676365
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.10676365
76central nervous system projection neuron axonogenesis (GO:0021952)3.07561099
77regulation of dendritic spine morphogenesis (GO:0061001)3.05747382
78regulation of neuronal synaptic plasticity (GO:0048168)3.03484770
79regulation of histone H3-K9 methylation (GO:0051570)3.03115631
80startle response (GO:0001964)3.03083710
81transmission of nerve impulse (GO:0019226)3.02334606
82regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00528138
83neuronal action potential propagation (GO:0019227)2.99988705
84negative regulation of gene silencing (GO:0060969)2.99504472
85female gamete generation (GO:0007292)2.99044303
86chromatin remodeling at centromere (GO:0031055)2.97505925
87cell migration in hindbrain (GO:0021535)2.97289979
88DNA methylation (GO:0006306)2.96783072
89DNA alkylation (GO:0006305)2.96783072
90synaptic vesicle endocytosis (GO:0048488)2.94557694
91regulation of postsynaptic membrane potential (GO:0060078)2.93794751
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93548366
93synapse assembly (GO:0007416)2.92526737
94CENP-A containing nucleosome assembly (GO:0034080)2.90061996
95reproductive system development (GO:0061458)2.89140868
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88550939
97regulation of centriole replication (GO:0046599)2.88270879
98cerebellar granule cell differentiation (GO:0021707)2.87982497
99mitotic metaphase plate congression (GO:0007080)2.84861112
100histone H4-K12 acetylation (GO:0043983)2.84699289
101mitotic spindle checkpoint (GO:0071174)2.83561243
102negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83021730
103mechanosensory behavior (GO:0007638)2.82321784
104histone exchange (GO:0043486)2.82148617
105innervation (GO:0060384)2.81395552
106regulation of sister chromatid cohesion (GO:0007063)2.81293748
107long-term memory (GO:0007616)2.80726206
108behavioral fear response (GO:0001662)2.80354069
109behavioral defense response (GO:0002209)2.80354069
110attachment of spindle microtubules to kinetochore (GO:0008608)2.79194414
111dendrite development (GO:0016358)2.77275253
112long-term synaptic potentiation (GO:0060291)2.76946404
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.76859956
114mitotic spindle assembly checkpoint (GO:0007094)2.76834786
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76406146
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75685897
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75685897
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75685897
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.75685897
120negative regulation of sister chromatid segregation (GO:0033046)2.75685897
121regulation of synapse structural plasticity (GO:0051823)2.75415334
122positive regulation of membrane potential (GO:0045838)2.75318895
123negative regulation of metanephros development (GO:0072217)2.73805375
124spindle assembly checkpoint (GO:0071173)2.73404895
125negative regulation of chromosome segregation (GO:0051985)2.72062524
126spindle checkpoint (GO:0031577)2.70498923
127regulation of synapse assembly (GO:0051963)2.70314992
128dendrite morphogenesis (GO:0048813)2.70183492
129chromosome organization (GO:0051276)2.69562464
130response to histamine (GO:0034776)2.69203935
131sister chromatid segregation (GO:0000819)2.69199420
132cerebellar Purkinje cell differentiation (GO:0021702)2.68771801
133auditory behavior (GO:0031223)2.68629547
134regulation of neurotransmitter secretion (GO:0046928)2.68344165
135regulation of meiotic cell cycle (GO:0051445)2.66703250
136pore complex assembly (GO:0046931)2.65982123
137histone H3-K36 demethylation (GO:0070544)2.65319339
138establishment of nucleus localization (GO:0040023)2.65062800
139regulation of cardioblast differentiation (GO:0051890)2.65004638
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64362559
141mRNA splice site selection (GO:0006376)2.64173887
142negative regulation of microtubule polymerization (GO:0031115)2.63831925
143regulation of synapse organization (GO:0050807)2.63544039
144fear response (GO:0042596)2.62004086
145positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61388578
146regulation of mitotic sister chromatid separation (GO:0010965)2.60492999
147regulation of mitotic sister chromatid segregation (GO:0033047)2.60492999
148regulation of sister chromatid segregation (GO:0033045)2.60492999
149meiotic cell cycle (GO:0051321)2.60374349
150cerebellum development (GO:0021549)2.59282775
151metaphase plate congression (GO:0051310)2.58908743
152hippocampus development (GO:0021766)2.58090743
153regulation of synaptic plasticity (GO:0048167)2.57355615
154synapse organization (GO:0050808)2.57036897
155negative regulation of inclusion body assembly (GO:0090084)2.56622531
156learning (GO:0007612)2.56374732
157mitotic sister chromatid segregation (GO:0000070)2.55615614
158neurotransmitter transport (GO:0006836)2.55431758
159mismatch repair (GO:0006298)2.55189275
160gamma-aminobutyric acid transport (GO:0015812)2.53471853
161seminiferous tubule development (GO:0072520)2.52341834
162regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.52198447
163regulation of mitotic metaphase/anaphase transition (GO:0030071)2.52198447
164cerebral cortex radially oriented cell migration (GO:0021799)2.50659587
165regulation of dendritic spine development (GO:0060998)2.50524834
166membrane hyperpolarization (GO:0060081)2.50178620
167regulation of respiratory system process (GO:0044065)2.49973228
168regulation of meiosis (GO:0040020)2.49703858
169embryonic body morphogenesis (GO:0010172)2.49399968
170cochlea development (GO:0090102)2.49256551
171histone H4-K5 acetylation (GO:0043981)2.48259135
172histone H4-K8 acetylation (GO:0043982)2.48259135
173glomerulus development (GO:0032835)2.48124828
174regulation of chromosome segregation (GO:0051983)2.47857160
175vesicle transport along microtubule (GO:0047496)2.47522624
176negative regulation of dendrite development (GO:2000171)2.47369459
177positive regulation of neurotransmitter secretion (GO:0001956)2.46647081
178regulation of double-strand break repair via homologous recombination (GO:0010569)2.45421777
179kinetochore organization (GO:0051383)2.45341051
180negative regulation of DNA recombination (GO:0045910)2.45238265
181histone H4-K16 acetylation (GO:0043984)2.45236776
182metanephric mesenchyme development (GO:0072075)2.43817476
183anterograde axon cargo transport (GO:0008089)2.43222958
184oogenesis (GO:0048477)2.43093640
185DNA unwinding involved in DNA replication (GO:0006268)2.42977796
186pyrimidine nucleobase catabolic process (GO:0006208)2.42963980
187regulation of neurotransmitter transport (GO:0051588)2.42411493
188skeletal muscle organ development (GO:0060538)2.42232298
189epithelial cell differentiation involved in kidney development (GO:0035850)2.42048520
190regulation of synaptic transmission, GABAergic (GO:0032228)2.42010487
191membrane depolarization (GO:0051899)2.41766980
192organelle transport along microtubule (GO:0072384)2.40752250
193parturition (GO:0007567)2.40612778
194dendritic spine organization (GO:0097061)2.39836678
195diaphragm development (GO:0060539)2.39318014
196striatum development (GO:0021756)2.37464007
197synaptic vesicle transport (GO:0048489)2.37287396
198establishment of synaptic vesicle localization (GO:0097480)2.37287396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.36757580
2E2F7_22180533_ChIP-Seq_HELA_Human4.86909135
3GBX2_23144817_ChIP-Seq_PC3_Human3.64970371
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82586659
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70809227
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69757581
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.44575316
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.42462991
9TAF15_26573619_Chip-Seq_HEK293_Human2.42176883
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32509676
11FUS_26573619_Chip-Seq_HEK293_Human2.28518734
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28206127
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27694514
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23960577
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19240448
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16724978
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16451376
18REST_21632747_ChIP-Seq_MESCs_Mouse2.14228980
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.10956982
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09834572
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04420609
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01917746
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01564827
24* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94271441
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90826603
26IGF1R_20145208_ChIP-Seq_DFB_Human1.90659030
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.81862484
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80669827
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79604040
30RNF2_27304074_Chip-Seq_NSC_Mouse1.79261088
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79092564
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79092564
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76081558
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.75607164
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75109429
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.74887140
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74861452
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73898770
39P300_19829295_ChIP-Seq_ESCs_Human1.72886212
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72538246
41SMAD4_21799915_ChIP-Seq_A2780_Human1.72293953
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71791937
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.68357739
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67119704
45ZNF274_21170338_ChIP-Seq_K562_Hela1.66261269
46EWS_26573619_Chip-Seq_HEK293_Human1.66050917
47* E2F1_21310950_ChIP-Seq_MCF-7_Human1.65407110
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.58690897
49* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55906546
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54920713
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53699505
52AR_21572438_ChIP-Seq_LNCaP_Human1.50471625
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49862885
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49630913
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48788620
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.46758912
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45727034
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45439260
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.45113286
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44678631
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43597786
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42356059
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41854802
64* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41412018
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40451627
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39644934
67MYC_18940864_ChIP-ChIP_HL60_Human1.39335779
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38696017
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36377306
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35657914
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32934928
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32934928
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32934928
74* MYC_18555785_ChIP-Seq_MESCs_Mouse1.32456106
75* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31327177
76STAT3_23295773_ChIP-Seq_U87_Human1.31005315
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30972121
78* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30901015
79SOX9_26525672_Chip-Seq_HEART_Mouse1.30878959
80ER_23166858_ChIP-Seq_MCF-7_Human1.30156042
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.28492082
82DROSHA_22980978_ChIP-Seq_HELA_Human1.28314661
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27577617
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25602118
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.24841434
86TCF4_23295773_ChIP-Seq_U87_Human1.24276205
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.21459888
88AR_25329375_ChIP-Seq_VCAP_Human1.20797542
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20395842
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.20355376
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.20095184
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19824293
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.19660487
94AR_21909140_ChIP-Seq_LNCAP_Human1.19107991
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18895804
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18895804
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17189618
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16517933
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.16186580
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15632421
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14991699
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14286653
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14116861
104* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13385360
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13278991
106JUN_21703547_ChIP-Seq_K562_Human1.11823969
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09662607
108SOX2_16153702_ChIP-ChIP_HESCs_Human1.09269151
109VDR_22108803_ChIP-Seq_LS180_Human1.09150796
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07807626
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07696062
112CBP_20019798_ChIP-Seq_JUKART_Human1.07696062
113RUNX2_22187159_ChIP-Seq_PCA_Human1.07579705
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06261413
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05848575
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.05420663
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04977226
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.04961721
119HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04073826
120GATA1_26923725_Chip-Seq_HPCs_Mouse1.03030624
121AR_19668381_ChIP-Seq_PC3_Human1.02561133
122RING1B_27294783_Chip-Seq_NPCs_Mouse1.00510582
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99766237
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99336214
125* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99286614
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98873083
127* ELK1_19687146_ChIP-ChIP_HELA_Human0.98667967
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98275360
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98257473
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97828881
131VDR_23849224_ChIP-Seq_CD4+_Human0.97704944
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97595411
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.97152387
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96999197
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96568935
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.96303328
137EST1_17652178_ChIP-ChIP_JURKAT_Human0.94742102
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93809072
139NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92811563
140* TTF2_22483619_ChIP-Seq_HELA_Human0.92278772
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91656229
142CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88775957
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88153993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.47364815
2MP0004859_abnormal_synaptic_plasticity4.32267308
3MP0003635_abnormal_synaptic_transmissio3.16064037
4MP0004270_analgesia2.87373958
5MP0002063_abnormal_learning/memory/cond2.73465938
6MP0008995_early_reproductive_senescence2.69504174
7MP0003787_abnormal_imprinting2.69081903
8MP0009745_abnormal_behavioral_response2.65802468
9MP0000778_abnormal_nervous_system2.39129702
10MP0003693_abnormal_embryo_hatching2.38868406
11MP0008877_abnormal_DNA_methylation2.37379485
12MP0009046_muscle_twitch2.36986418
13MP0002064_seizures2.33922114
14MP0001968_abnormal_touch/_nociception2.33911039
15MP0002572_abnormal_emotion/affect_behav2.29563852
16MP0005423_abnormal_somatic_nervous2.14028860
17MP0002734_abnormal_mechanical_nocicepti2.13571356
18MP0003122_maternal_imprinting2.12072775
19MP0003121_genomic_imprinting2.10617730
20MP0006276_abnormal_autonomic_nervous1.99492464
21MP0003123_paternal_imprinting1.98858131
22MP0002184_abnormal_innervation1.98285997
23MP0001486_abnormal_startle_reflex1.97182992
24MP0002735_abnormal_chemical_nociception1.96598112
25MP0002736_abnormal_nociception_after1.94191058
26MP0002272_abnormal_nervous_system1.93707235
27MP0000653_abnormal_sex_gland1.88797074
28MP0000383_abnormal_hair_follicle1.88634882
29MP0001529_abnormal_vocalization1.86402543
30MP0001188_hyperpigmentation1.86327449
31MP0001661_extended_life_span1.82050570
32MP0001440_abnormal_grooming_behavior1.70421989
33MP0002067_abnormal_sensory_capabilities1.70102081
34MP0003567_abnormal_fetal_cardiomyocyte1.65909453
35MP0005389_reproductive_system_phenotype1.65468730
36MP0002557_abnormal_social/conspecific_i1.60593011
37MP0003111_abnormal_nucleus_morphology1.60498921
38MP0000569_abnormal_digit_pigmentation1.58993977
39MP0004924_abnormal_behavior1.56491374
40MP0005386_behavior/neurological_phenoty1.56491374
41MP0004811_abnormal_neuron_physiology1.56067619
42MP0003077_abnormal_cell_cycle1.55704327
43MP0004957_abnormal_blastocyst_morpholog1.54628966
44MP0000955_abnormal_spinal_cord1.50314895
45MP0002084_abnormal_developmental_patter1.46200690
46MP0002822_catalepsy1.43542578
47MP0009780_abnormal_chondrocyte_physiolo1.39080272
48MP0002733_abnormal_thermal_nociception1.36452665
49MP0001984_abnormal_olfaction1.36123382
50MP0002882_abnormal_neuron_morphology1.35977670
51MP0010678_abnormal_skin_adnexa1.35072860
52MP0006292_abnormal_olfactory_placode1.34678675
53MP0005646_abnormal_pituitary_gland1.32893795
54MP0000631_abnormal_neuroendocrine_gland1.32804126
55MP0001970_abnormal_pain_threshold1.31978841
56MP0002152_abnormal_brain_morphology1.31959124
57MP0001501_abnormal_sleep_pattern1.27472894
58MP0008932_abnormal_embryonic_tissue1.26337209
59MP0003115_abnormal_respiratory_system1.25641793
60MP0003890_abnormal_embryonic-extraembry1.25535516
61MP0000537_abnormal_urethra_morphology1.24676767
62MP0001730_embryonic_growth_arrest1.22779394
63MP0009703_decreased_birth_body1.21536215
64MP0003943_abnormal_hepatobiliary_system1.21488902
65MP0003861_abnormal_nervous_system1.20944852
66MP0005499_abnormal_olfactory_system1.20865522
67MP0005394_taste/olfaction_phenotype1.20865522
68MP0002233_abnormal_nose_morphology1.19621425
69MP0001119_abnormal_female_reproductive1.18831190
70MP0004885_abnormal_endolymph1.17894696
71MP0008569_lethality_at_weaning1.17568948
72MP0002066_abnormal_motor_capabilities/c1.15813046
73MP0001905_abnormal_dopamine_level1.12626444
74MP0006072_abnormal_retinal_apoptosis1.09740351
75MP0001293_anophthalmia1.08211330
76MP0001697_abnormal_embryo_size1.07763663
77MP0002161_abnormal_fertility/fecundity1.07758508
78MP0002085_abnormal_embryonic_tissue1.07217983
79MP0001177_atelectasis1.07201531
80MP0005551_abnormal_eye_electrophysiolog1.07086006
81MP0003786_premature_aging1.06604993
82MP0000427_abnormal_hair_cycle1.04908819
83MP0005645_abnormal_hypothalamus_physiol1.03007569
84MP0001502_abnormal_circadian_rhythm1.02387840
85MP0005380_embryogenesis_phenotype1.02044701
86MP0001672_abnormal_embryogenesis/_devel1.02044701
87MP0001919_abnormal_reproductive_system1.01089411
88MP0003698_abnormal_male_reproductive1.00906389
89MP0002751_abnormal_autonomic_nervous1.00849161
90MP0010368_abnormal_lymphatic_system1.00538374
91MP0003221_abnormal_cardiomyocyte_apopto0.98286108
92MP0000566_synostosis0.97978704
93MP0003942_abnormal_urinary_system0.97058936
94MP0002009_preneoplasia0.96800075
95MP0002752_abnormal_somatic_nervous0.94705470
96MP0008789_abnormal_olfactory_epithelium0.94465384
97MP0002697_abnormal_eye_size0.93407074
98MP0000049_abnormal_middle_ear0.93330338
99MP0003879_abnormal_hair_cell0.92819479
100MP0004142_abnormal_muscle_tone0.92471373
101MP0004742_abnormal_vestibular_system0.92069043
102MP0001286_abnormal_eye_development0.90773674
103MP0003936_abnormal_reproductive_system0.90482918
104MP0001485_abnormal_pinna_reflex0.90195220
105MP0000647_abnormal_sebaceous_gland0.89855338
106MP0008007_abnormal_cellular_replicative0.89239695
107MP0001963_abnormal_hearing_physiology0.88273060
108MP0005187_abnormal_penis_morphology0.88082938
109MP0003984_embryonic_growth_retardation0.87597748
110MP0002653_abnormal_ependyma_morphology0.86586782
111MP0002249_abnormal_larynx_morphology0.86380689
112MP0009672_abnormal_birth_weight0.86267058
113MP0005171_absent_coat_pigmentation0.86215432
114MP0009697_abnormal_copulation0.85936248
115MP0002088_abnormal_embryonic_growth/wei0.85474439
116MP0003935_abnormal_craniofacial_develop0.84903777
117MP0004197_abnormal_fetal_growth/weight/0.84030056
118MP0010030_abnormal_orbit_morphology0.83963132
119MP0003119_abnormal_digestive_system0.82156428
120MP0003385_abnormal_body_wall0.81613819
121MP0002210_abnormal_sex_determination0.81398082
122MP0000350_abnormal_cell_proliferation0.80209627
123MP0006035_abnormal_mitochondrial_morpho0.79377887
124MP0005253_abnormal_eye_physiology0.78771368
125MP0010094_abnormal_chromosome_stability0.78355115
126MP0002102_abnormal_ear_morphology0.78313058
127MP0003718_maternal_effect0.78174419
128MP0003938_abnormal_ear_development0.78160170
129MP0002160_abnormal_reproductive_system0.77467759
130MP0002081_perinatal_lethality0.77336928
131MP0003699_abnormal_female_reproductive0.76745027
132MP0003632_abnormal_nervous_system0.76699837
133MP0009053_abnormal_anal_canal0.75661218
134MP0005623_abnormal_meninges_morphology0.75550779
135MP0001943_abnormal_respiration0.75332568
136MP0009384_cardiac_valve_regurgitation0.75292353
137MP0001929_abnormal_gametogenesis0.74831880
138MP0005391_vision/eye_phenotype0.74131685
139MP0003755_abnormal_palate_morphology0.73737320
140MP0000026_abnormal_inner_ear0.73579984
141MP0003631_nervous_system_phenotype0.72938984
142MP0002638_abnormal_pupillary_reflex0.72356985
143MP0003937_abnormal_limbs/digits/tail_de0.71469116
144MP0008058_abnormal_DNA_repair0.70657326
145MP0008057_abnormal_DNA_replication0.69909791
146MP0002909_abnormal_adrenal_gland0.69201401
147MP0002069_abnormal_eating/drinking_beha0.68248075
148MP0001299_abnormal_eye_distance/0.68247698
149MP0005409_darkened_coat_color0.67093870
150MP0004085_abnormal_heartbeat0.66054198
151MP0004145_abnormal_muscle_electrophysio0.65718830
152MP0002234_abnormal_pharynx_morphology0.65326018
153MP0001145_abnormal_male_reproductive0.65231099
154MP0003315_abnormal_perineum_morphology0.64944479

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.83661892
2Gonadal dysgenesis (HP:0000133)4.07939677
3Epileptic encephalopathy (HP:0200134)3.66847367
4Atonic seizures (HP:0010819)3.61441654
5Focal seizures (HP:0007359)3.57365722
6Abnormal lung lobation (HP:0002101)3.45937911
7Febrile seizures (HP:0002373)3.42750732
8Myokymia (HP:0002411)3.28672598
9Osteomalacia (HP:0002749)3.15075996
10Hyperventilation (HP:0002883)3.11550584
11Progressive cerebellar ataxia (HP:0002073)3.06093478
12Oligodactyly (hands) (HP:0001180)3.04205639
13Gonadotropin excess (HP:0000837)3.01999228
14Broad-based gait (HP:0002136)3.01401288
15Testicular neoplasm (HP:0010788)2.96077253
16Hypoplastic left heart (HP:0004383)2.92159271
17Abnormality of the labia minora (HP:0012880)2.90834024
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89482137
19Anomalous pulmonary venous return (HP:0010772)2.85446375
20Chromsome breakage (HP:0040012)2.84641270
21Visual hallucinations (HP:0002367)2.76679437
22Absence seizures (HP:0002121)2.73956015
23Gait imbalance (HP:0002141)2.72708351
24Abnormal ventriculo-arterial connection (HP:0011563)2.72694064
25Transposition of the great arteries (HP:0001669)2.72694064
26Abnormal connection of the cardiac segments (HP:0011545)2.72694064
27Termporal pattern (HP:0011008)2.72125790
28Insidious onset (HP:0003587)2.72125790
29Drooling (HP:0002307)2.67452598
30Excessive salivation (HP:0003781)2.67452598
31Impaired vibration sensation in the lower limbs (HP:0002166)2.65334869
32True hermaphroditism (HP:0010459)2.65198127
33Ectopic kidney (HP:0000086)2.64978621
34Oligodactyly (HP:0012165)2.63694733
35Gaze-evoked nystagmus (HP:0000640)2.61370773
36Proximal placement of thumb (HP:0009623)2.59025375
37Abnormal hair whorl (HP:0010721)2.58310689
38Protruding tongue (HP:0010808)2.57866930
39Abnormality of the corticospinal tract (HP:0002492)2.54474955
40Increased nuchal translucency (HP:0010880)2.51883214
41Aplasia/Hypoplasia of the sternum (HP:0006714)2.49342268
42Abnormality of the pulmonary veins (HP:0011718)2.48285881
43Medial flaring of the eyebrow (HP:0010747)2.46158140
44Dialeptic seizures (HP:0011146)2.41120524
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.36828144
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36828144
47Urinary bladder sphincter dysfunction (HP:0002839)2.33866615
48Male pseudohermaphroditism (HP:0000037)2.32880209
49Congenital primary aphakia (HP:0007707)2.32747978
50Deviation of the thumb (HP:0009603)2.29434179
51Truncal ataxia (HP:0002078)2.28445746
52Spastic paraplegia (HP:0001258)2.27512857
53Papillary thyroid carcinoma (HP:0002895)2.26630381
54Urinary urgency (HP:0000012)2.26613086
55Hypoplastic heart (HP:0001961)2.25787276
56Generalized tonic-clonic seizures (HP:0002069)2.24808786
57Horizontal nystagmus (HP:0000666)2.20097608
58Nephrogenic diabetes insipidus (HP:0009806)2.19030631
59Absent speech (HP:0001344)2.17169384
60Limb dystonia (HP:0002451)2.15898202
61Morphological abnormality of the pyramidal tract (HP:0002062)2.13075365
62Paraplegia (HP:0010550)2.12324830
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.12171864
64Absent/shortened dynein arms (HP:0200106)2.12171864
65Genital tract atresia (HP:0001827)2.12071854
66Rhabdomyosarcoma (HP:0002859)2.10349952
67Cortical dysplasia (HP:0002539)2.10285467
68Amblyopia (HP:0000646)2.10042860
69Colon cancer (HP:0003003)2.09695064
70Abnormality of chromosome stability (HP:0003220)2.07600001
71Facial hemangioma (HP:0000329)2.06231565
72Vaginal atresia (HP:0000148)2.03687331
73Poor eye contact (HP:0000817)2.03545949
74Medulloblastoma (HP:0002885)2.02041369
75Specific learning disability (HP:0001328)2.00857480
76Epileptiform EEG discharges (HP:0011182)1.99879894
77Germ cell neoplasia (HP:0100728)1.99452536
78Volvulus (HP:0002580)1.97814197
79Hypoplasia of the brainstem (HP:0002365)1.97141219
80Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97141219
81Truncal obesity (HP:0001956)1.97042542
82Inappropriate behavior (HP:0000719)1.96357072
83Lissencephaly (HP:0001339)1.95687326
84Poor coordination (HP:0002370)1.95334798
85Spastic gait (HP:0002064)1.94738609
86Genetic anticipation (HP:0003743)1.94349658
87Tubulointerstitial nephritis (HP:0001970)1.94239368
88Abnormal ciliary motility (HP:0012262)1.93304410
89Gastroesophageal reflux (HP:0002020)1.92284637
90Ankle clonus (HP:0011448)1.92185468
91Meckel diverticulum (HP:0002245)1.91765418
92Abnormal sex determination (HP:0012244)1.91626471
93Sex reversal (HP:0012245)1.91626471
94Retinal dysplasia (HP:0007973)1.91078611
95Embryonal neoplasm (HP:0002898)1.90790849
96Abnormal respiratory motile cilium physiology (HP:0012261)1.89374735
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.88763632
98Ependymoma (HP:0002888)1.88297126
99Small intestinal stenosis (HP:0012848)1.86485700
100Duodenal stenosis (HP:0100867)1.86485700
101EEG with generalized epileptiform discharges (HP:0011198)1.86162981
102Preaxial foot polydactyly (HP:0001841)1.84351412
103Abnormal respiratory epithelium morphology (HP:0012253)1.83912435
104Abnormal respiratory motile cilium morphology (HP:0005938)1.83912435
105Abnormality of the ileum (HP:0001549)1.83096442
106Female pseudohermaphroditism (HP:0010458)1.82961268
107Impaired smooth pursuit (HP:0007772)1.82654886
108Ovarian neoplasm (HP:0100615)1.81638423
109Abnormality of ocular smooth pursuit (HP:0000617)1.81007861
110Abnormality of salivation (HP:0100755)1.80268183
111Chronic hepatic failure (HP:0100626)1.79785229
112Aqueductal stenosis (HP:0002410)1.78591334
113Fetal akinesia sequence (HP:0001989)1.78366717
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78104321
115Absent radius (HP:0003974)1.77737447
116Primary amenorrhea (HP:0000786)1.74796219
117Hypsarrhythmia (HP:0002521)1.73432917
118Congenital diaphragmatic hernia (HP:0000776)1.73283663
119Nephroblastoma (Wilms tumor) (HP:0002667)1.72642655
120Abnormality of the hip-girdle musculature (HP:0001445)1.72583034
121Abnormality of the musculature of the pelvis (HP:0001469)1.72583034
122Preaxial hand polydactyly (HP:0001177)1.71495689
123Progressive inability to walk (HP:0002505)1.71422054
124Optic nerve coloboma (HP:0000588)1.71313874
125Abnormality of the duodenum (HP:0002246)1.70409382
126Intellectual disability, moderate (HP:0002342)1.70348240
127Autism (HP:0000717)1.69963048
128Renal duplication (HP:0000075)1.69421516
129Embryonal renal neoplasm (HP:0011794)1.68951718
130Absent forearm bone (HP:0003953)1.68711870
131Aplasia involving forearm bones (HP:0009822)1.68711870
132Scotoma (HP:0000575)1.68356741
133Pointed chin (HP:0000307)1.66707524
134Abnormality of the astrocytes (HP:0100707)1.66033873
135Astrocytoma (HP:0009592)1.66033873
136Mesangial abnormality (HP:0001966)1.65643398
137Supernumerary spleens (HP:0009799)1.65395378
138Capillary hemangiomas (HP:0005306)1.64601150
139Abnormality of chromosome segregation (HP:0002916)1.63386909
140Dysdiadochokinesis (HP:0002075)1.62539562
141Renovascular hypertension (HP:0100817)1.62314614
142Pheochromocytoma (HP:0002666)1.61707566
143Depression (HP:0000716)1.60633484
144Impaired vibratory sensation (HP:0002495)1.60599744
145Overriding aorta (HP:0002623)1.59898450
146Broad distal phalanx of finger (HP:0009836)1.59747353
147Postaxial hand polydactyly (HP:0001162)1.59741340
148Impaired social interactions (HP:0000735)1.59623657
149Abnormal social behavior (HP:0012433)1.59623657
150Insomnia (HP:0100785)1.59341687
151Agnosia (HP:0010524)1.59077632
152Sacral dimple (HP:0000960)1.58615165
153Stereotypic behavior (HP:0000733)1.57932745
154Hyperthyroidism (HP:0000836)1.57328858
155Widely spaced teeth (HP:0000687)1.56968753
156Abnormality of DNA repair (HP:0003254)1.56199544
157Abnormality of the renal medulla (HP:0100957)1.56032235
158Complete atrioventricular canal defect (HP:0001674)1.55941334
159Neoplasm of striated muscle (HP:0009728)1.55746896
160Omphalocele (HP:0001539)1.55322318
161Lower limb muscle weakness (HP:0007340)1.55107076
162Obsessive-compulsive behavior (HP:0000722)1.54436945
163Molar tooth sign on MRI (HP:0002419)1.53227389
164Abnormality of midbrain morphology (HP:0002418)1.53227389
165Inability to walk (HP:0002540)1.52984440
166Thyroid carcinoma (HP:0002890)1.52826639
167Abnormal eating behavior (HP:0100738)1.52814993
168Pelvic girdle muscle weakness (HP:0003749)1.51175238
169Short foot (HP:0001773)1.49572569
170* Shoulder girdle muscle weakness (HP:0003547)1.49135390
171Nephronophthisis (HP:0000090)1.48928282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.34109356
2CASK4.14313060
3NTRK33.32909778
4EPHA43.20962330
5MAP3K43.03284552
6PNCK2.74834503
7MAP2K72.55871361
8PLK22.35126480
9CAMK1G2.23138209
10MET2.17164421
11ACVR1B2.12481078
12MINK12.11437094
13CCNB11.98353285
14MAPK131.93906443
15TTK1.91290771
16NTRK21.88941595
17MAP3K91.77659653
18LIMK11.76597203
19KSR11.74863175
20STK38L1.66407958
21ERBB31.62234444
22MAP3K121.61927275
23TSSK61.54908785
24CDC71.54593808
25TRIM281.51528114
26DAPK21.48992579
27BCR1.43257034
28PLK31.42967868
29BRSK21.42219846
30MAP2K41.38915714
31DAPK11.28748766
32UHMK11.27124698
33AKT31.23256144
34MAP3K101.22706068
35PRPF4B1.21823005
36PASK1.21075893
37BMX1.15583045
38PAK61.15265370
39CDK51.13193596
40PRKCG1.08909799
41ATR1.08070122
42LATS11.07728791
43CSNK1G21.07607915
44MAP4K21.07296221
45SRPK11.05824190
46MKNK11.05662302
47MKNK21.05055460
48CDK191.04998923
49SGK21.04535011
50TNIK1.00458360
51WNK30.99090868
52PINK10.96987508
53DYRK20.96795032
54DYRK1A0.95790486
55SGK4940.94184969
56SGK2230.94184969
57PBK0.90785749
58CDC42BPA0.90570551
59TAF10.89136653
60CSNK1G30.89113727
61CDK180.87706294
62CDK40.86918963
63SIK20.83792147
64PDK20.83760494
65NEK10.83463576
66BUB10.82168356
67EIF2AK30.81175920
68CAMK2B0.80688048
69CDK140.80673526
70CDK150.80568300
71OXSR10.80012113
72ZAK0.79179304
73CAMK2A0.77408717
74PDK30.76232655
75PDK40.76232655
76* ATM0.75963510
77DYRK30.74879176
78CSNK1A1L0.74402805
79* CHEK10.74070811
80YES10.71805156
81BMPR1B0.70966311
82GRK50.70765602
83PDGFRB0.69055942
84BRSK10.68398122
85NUAK10.67406024
86NLK0.66946245
87CDK11A0.66673646
88TYRO30.66156059
89CAMKK10.65132100
90STK240.64961803
91ROCK20.64228605
92NEK90.61627662
93BRD40.59816093
94RET0.58257986
95PRKD30.58059992
96STK30.58040815
97SGK30.57047015
98LATS20.56165518
99PTK2B0.55074558
100RPS6KA40.54142802
101VRK10.51479382
102NEK20.50664103
103CSNK1G10.50049939
104AURKA0.49306411
105BMPR20.49182899
106CDK10.48447053
107FGFR20.48172036
108PRKCE0.47972835
109CDK20.47970828
110CSNK1E0.47108346
111NEK60.45894828
112SIK30.45688459
113* SGK10.45335516
114CDK30.45029063
115CHEK20.44988772
116MAP3K60.43950238
117CSF1R0.43157962
118CDK60.42212836
119CDK80.41950539
120WEE10.41763613
121PLK10.41460327
122MAPK100.41409219
123KSR20.41325302
124RPS6KB10.41185829
125STK390.41059598
126PKN10.40365007
127CDK70.39609763
128AURKB0.39349792
129BRAF0.39070576
130FGFR10.38959158
131PHKG20.38577494
132PHKG10.38577494
133NME10.38269255
134PRKCB0.37613213
135FGR0.37195234
136GSK3B0.36980976
137PLK40.36816481
138MAPK80.36324544
139PAK30.36305786
140STK110.36245470

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94918986
2DNA replication_Homo sapiens_hsa030303.07583350
3Non-homologous end-joining_Homo sapiens_hsa034503.07330478
4Synaptic vesicle cycle_Homo sapiens_hsa047212.87003901
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60714418
6Base excision repair_Homo sapiens_hsa034102.57958522
7Long-term potentiation_Homo sapiens_hsa047202.50910918
8Amphetamine addiction_Homo sapiens_hsa050312.33841815
9Circadian entrainment_Homo sapiens_hsa047132.33139181
10GABAergic synapse_Homo sapiens_hsa047272.32799862
11Morphine addiction_Homo sapiens_hsa050322.28196094
12Homologous recombination_Homo sapiens_hsa034402.27637876
13Glutamatergic synapse_Homo sapiens_hsa047242.24298999
14Olfactory transduction_Homo sapiens_hsa047402.18049339
15Dopaminergic synapse_Homo sapiens_hsa047282.16835026
16Taste transduction_Homo sapiens_hsa047421.96902358
17Serotonergic synapse_Homo sapiens_hsa047261.72948266
18Oocyte meiosis_Homo sapiens_hsa041141.70973498
19Long-term depression_Homo sapiens_hsa047301.69586574
20Axon guidance_Homo sapiens_hsa043601.68680658
21Regulation of autophagy_Homo sapiens_hsa041401.64927238
22Collecting duct acid secretion_Homo sapiens_hsa049661.63457655
23Renin secretion_Homo sapiens_hsa049241.59982535
24Cholinergic synapse_Homo sapiens_hsa047251.56286058
25Propanoate metabolism_Homo sapiens_hsa006401.52894279
26Cocaine addiction_Homo sapiens_hsa050301.48130158
27Salivary secretion_Homo sapiens_hsa049701.46284616
28Insulin secretion_Homo sapiens_hsa049111.44825249
29Phototransduction_Homo sapiens_hsa047441.41859772
30Selenocompound metabolism_Homo sapiens_hsa004501.38704787
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38501334
32Oxytocin signaling pathway_Homo sapiens_hsa049211.38034807
33Calcium signaling pathway_Homo sapiens_hsa040201.34239325
34Lysine degradation_Homo sapiens_hsa003101.31150069
35Gastric acid secretion_Homo sapiens_hsa049711.31064356
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29437159
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27826241
38Gap junction_Homo sapiens_hsa045401.27595570
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26460377
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25012912
41Alcoholism_Homo sapiens_hsa050341.24917268
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20627750
43mRNA surveillance pathway_Homo sapiens_hsa030151.19038014
44TGF-beta signaling pathway_Homo sapiens_hsa043501.19026107
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17149393
46GnRH signaling pathway_Homo sapiens_hsa049121.15391192
47Vibrio cholerae infection_Homo sapiens_hsa051101.14609264
48Steroid biosynthesis_Homo sapiens_hsa001001.12791840
49Protein export_Homo sapiens_hsa030601.09007085
50Melanogenesis_Homo sapiens_hsa049161.08825819
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08425320
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06902556
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04677646
54Estrogen signaling pathway_Homo sapiens_hsa049151.01168590
55Fatty acid elongation_Homo sapiens_hsa000621.00867097
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00410936
57cAMP signaling pathway_Homo sapiens_hsa040241.00218888
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99985778
59beta-Alanine metabolism_Homo sapiens_hsa004100.98526086
60ErbB signaling pathway_Homo sapiens_hsa040120.98191865
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97267908
62RNA polymerase_Homo sapiens_hsa030200.96228170
63Wnt signaling pathway_Homo sapiens_hsa043100.96122990
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93776962
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89831496
66Colorectal cancer_Homo sapiens_hsa052100.89301847
67Spliceosome_Homo sapiens_hsa030400.88952834
68Glioma_Homo sapiens_hsa052140.87278713
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87142727
70Fanconi anemia pathway_Homo sapiens_hsa034600.86257066
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84456775
72Cardiac muscle contraction_Homo sapiens_hsa042600.80295389
73One carbon pool by folate_Homo sapiens_hsa006700.79272437
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.79158142
75RNA transport_Homo sapiens_hsa030130.78421675
76Cell cycle_Homo sapiens_hsa041100.75933182
77Type II diabetes mellitus_Homo sapiens_hsa049300.73457209
78Hedgehog signaling pathway_Homo sapiens_hsa043400.73387895
79MAPK signaling pathway_Homo sapiens_hsa040100.73325036
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71622587
81Huntingtons disease_Homo sapiens_hsa050160.71356569
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70624277
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69293368
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68988703
85p53 signaling pathway_Homo sapiens_hsa041150.68822274
86Hippo signaling pathway_Homo sapiens_hsa043900.68037251
87Endometrial cancer_Homo sapiens_hsa052130.67929786
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67421100
89Pyruvate metabolism_Homo sapiens_hsa006200.67369961
90Folate biosynthesis_Homo sapiens_hsa007900.66112210
91Basal transcription factors_Homo sapiens_hsa030220.65152767
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.64953216
93Adherens junction_Homo sapiens_hsa045200.63741292
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63351941
95Dorso-ventral axis formation_Homo sapiens_hsa043200.63055416
96Alzheimers disease_Homo sapiens_hsa050100.62382005
97Oxidative phosphorylation_Homo sapiens_hsa001900.59568343
98Fatty acid metabolism_Homo sapiens_hsa012120.59349205
99Pyrimidine metabolism_Homo sapiens_hsa002400.57631654
100Parkinsons disease_Homo sapiens_hsa050120.57133327
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56379428
102Circadian rhythm_Homo sapiens_hsa047100.56306857
103N-Glycan biosynthesis_Homo sapiens_hsa005100.56175470
104Renal cell carcinoma_Homo sapiens_hsa052110.55936622
105Ras signaling pathway_Homo sapiens_hsa040140.55745932
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55057050
107RNA degradation_Homo sapiens_hsa030180.54989354
108Basal cell carcinoma_Homo sapiens_hsa052170.54496896
109Glucagon signaling pathway_Homo sapiens_hsa049220.53598635
110Dilated cardiomyopathy_Homo sapiens_hsa054140.53069421
111Rap1 signaling pathway_Homo sapiens_hsa040150.51968323
112Nucleotide excision repair_Homo sapiens_hsa034200.51719731
113Mismatch repair_Homo sapiens_hsa034300.51693132
114Inositol phosphate metabolism_Homo sapiens_hsa005620.51261471
115Purine metabolism_Homo sapiens_hsa002300.51017463
116Fatty acid biosynthesis_Homo sapiens_hsa000610.50888381
117Butanoate metabolism_Homo sapiens_hsa006500.50178652
118Choline metabolism in cancer_Homo sapiens_hsa052310.49318287
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48843306
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48639483
121Arginine and proline metabolism_Homo sapiens_hsa003300.48301092
122Thyroid hormone synthesis_Homo sapiens_hsa049180.46169268
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46055902
124Tight junction_Homo sapiens_hsa045300.46003862
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44883445
126mTOR signaling pathway_Homo sapiens_hsa041500.44531160
127Type I diabetes mellitus_Homo sapiens_hsa049400.44184388
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44033400
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43952916
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.42517183
131Melanoma_Homo sapiens_hsa052180.42052781
132AMPK signaling pathway_Homo sapiens_hsa041520.41768478
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41512778
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.40641671
1352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40441236
136Prostate cancer_Homo sapiens_hsa052150.38602213
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37507275
138Non-small cell lung cancer_Homo sapiens_hsa052230.35420716
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35419147
140Systemic lupus erythematosus_Homo sapiens_hsa053220.35330554
141Vitamin B6 metabolism_Homo sapiens_hsa007500.34047561
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30500358
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27512273

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