MAU2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.51726604
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.51726604
3negative regulation of erythrocyte differentiation (GO:0045647)5.05712732
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43496734
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26978907
6regulation of gamma-delta T cell activation (GO:0046643)4.10086750
7metanephric mesenchyme development (GO:0072075)4.09334859
8antigen processing and presentation of endogenous antigen (GO:0019883)4.04771590
9regulation of gamma-delta T cell differentiation (GO:0045586)3.96091786
10positive regulation by symbiont of host defense response (GO:0052509)3.92965405
11modulation by symbiont of host defense response (GO:0052031)3.92965405
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.92965405
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.92965405
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.92965405
15modulation by symbiont of host immune response (GO:0052553)3.92965405
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.83440994
17response to muramyl dipeptide (GO:0032495)3.81277524
18kidney mesenchyme development (GO:0072074)3.78938742
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.78137286
20positive thymic T cell selection (GO:0045059)3.77737506
21mannose metabolic process (GO:0006013)3.72903336
22thymic T cell selection (GO:0045061)3.68329855
23histone H3-K4 trimethylation (GO:0080182)3.59909836
24righting reflex (GO:0060013)3.53666221
25detection of bacterium (GO:0016045)3.53434111
26detection of other organism (GO:0098543)3.53135828
27leukocyte aggregation (GO:0070486)3.52745616
28histone H3-K36 demethylation (GO:0070544)3.52214200
29negative thymic T cell selection (GO:0045060)3.50657456
30neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.49035549
31T cell selection (GO:0045058)3.39383506
32regulation of B cell receptor signaling pathway (GO:0050855)3.38832504
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38781343
34germinal center formation (GO:0002467)3.36961220
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.36956689
36negative T cell selection (GO:0043383)3.35676548
37macrophage activation involved in immune response (GO:0002281)3.33358415
38positive regulation of action potential (GO:0045760)3.30934213
39cellular extravasation (GO:0045123)3.27532498
40regulation of ARF GTPase activity (GO:0032312)3.25472581
41negative regulation of glycogen biosynthetic process (GO:0045719)3.19071859
42response to interleukin-15 (GO:0070672)3.16713225
43nephron tubule morphogenesis (GO:0072078)3.15922810
44nephron epithelium morphogenesis (GO:0072088)3.15922810
45response to peptidoglycan (GO:0032494)3.15169382
46negative regulation of leukocyte mediated immunity (GO:0002704)3.13730821
47B cell receptor signaling pathway (GO:0050853)3.11699591
48tolerance induction (GO:0002507)3.10509030
49positive regulation of histone deacetylation (GO:0031065)3.09530716
50negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.08077363
51histone demethylation (GO:0016577)3.07049499
52protein dealkylation (GO:0008214)3.03653225
53protein demethylation (GO:0006482)3.03653225
54regulation of ARF protein signal transduction (GO:0032012)2.99438190
55detection of external biotic stimulus (GO:0098581)2.92507611
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91950421
57histone lysine demethylation (GO:0070076)2.90851033
58histone H3-K4 methylation (GO:0051568)2.90471456
59regulation of interferon-beta biosynthetic process (GO:0045357)2.86546338
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85169580
61activated T cell proliferation (GO:0050798)2.84739217
62negative regulation of T cell mediated immunity (GO:0002710)2.83491792
63positive regulation of receptor recycling (GO:0001921)2.80381548
64negative regulation of innate immune response (GO:0045824)2.80356118
65positive regulation of Rap GTPase activity (GO:0032854)2.78906778
66negative regulation of cAMP-mediated signaling (GO:0043951)2.77627987
67neural tube formation (GO:0001841)2.77625075
68spinal cord development (GO:0021510)2.77251293
69regulation of mast cell degranulation (GO:0043304)2.75724212
70cerebellar Purkinje cell differentiation (GO:0021702)2.75644619
71regulation of leukocyte degranulation (GO:0043300)2.74812718
72regulation of glycogen (starch) synthase activity (GO:2000465)2.74456171
73mesenchymal cell differentiation involved in renal system development (GO:2001012)2.74291448
74mesenchymal cell differentiation involved in kidney development (GO:0072161)2.74291448
75response to type I interferon (GO:0034340)2.72884190
76regulation of T-helper 2 cell differentiation (GO:0045628)2.72593456
77signal complex assembly (GO:0007172)2.72188196
78cell differentiation involved in metanephros development (GO:0072202)2.72123683
79positive regulation of protein deacetylation (GO:0090312)2.71401962
80regulation of necroptotic process (GO:0060544)2.69081791
81regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68789634
82generation of neurons (GO:0048699)2.67855303
83histone H4 deacetylation (GO:0070933)2.66822859
84negative regulation of interleukin-12 production (GO:0032695)2.66408216
853-UTR-mediated mRNA stabilization (GO:0070935)2.66290410
86intracellular estrogen receptor signaling pathway (GO:0030520)2.65904601
87negative regulation of myotube differentiation (GO:0010832)2.65150476
88Peyers patch development (GO:0048541)2.64475131
89mucosal-associated lymphoid tissue development (GO:0048537)2.64475131
90cellular response to type I interferon (GO:0071357)2.64050674
91type I interferon signaling pathway (GO:0060337)2.64050674
92phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.63265988
93neuron cell-cell adhesion (GO:0007158)2.62404807
94regulation of B cell differentiation (GO:0045577)2.62098620
95positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61308591
96detection of biotic stimulus (GO:0009595)2.61068407
97response to host immune response (GO:0052572)2.60842098
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60842098
99mRNA splice site selection (GO:0006376)2.60828169
100renal tubule morphogenesis (GO:0061333)2.60736967
101negative regulation of interleukin-6 production (GO:0032715)2.60169590
102histone lysine methylation (GO:0034968)2.59745408
103histone H3-K9 demethylation (GO:0033169)2.59015621
104peptidyl-lysine trimethylation (GO:0018023)2.58921075
105negative regulation of glycogen metabolic process (GO:0070874)2.58107984
106response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.57197302
107response to host (GO:0075136)2.57197302
108response to host defenses (GO:0052200)2.57197302
109replicative senescence (GO:0090399)2.56347609
110natural killer cell differentiation (GO:0001779)2.56300757
111locomotory exploration behavior (GO:0035641)2.55830645
112poly(A)+ mRNA export from nucleus (GO:0016973)2.55070181
113detection of molecule of bacterial origin (GO:0032490)2.55062903
114positive regulation of B cell differentiation (GO:0045579)2.51910424
115negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.51842526
116negative regulation of T-helper cell differentiation (GO:0045623)2.51842526
117negative regulation of toll-like receptor signaling pathway (GO:0034122)2.51671160
118mitochondrion transport along microtubule (GO:0047497)2.51168725
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51168725
120behavioral response to ethanol (GO:0048149)2.49735616
121cellular response to interleukin-15 (GO:0071350)2.48755871
122regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46745373
123response to laminar fluid shear stress (GO:0034616)2.46507679
124regulation of platelet aggregation (GO:0090330)2.46297188
125spinal cord motor neuron differentiation (GO:0021522)2.45906561
126neural tube development (GO:0021915)2.45742636
127regulation of T cell tolerance induction (GO:0002664)2.45572787
128central nervous system projection neuron axonogenesis (GO:0021952)2.45493184
129negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.44997966
130histone deubiquitination (GO:0016578)2.44995931
131regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.44567039
132regulation of natural killer cell mediated immunity (GO:0002715)2.44567039
133regulation of mast cell activation involved in immune response (GO:0033006)2.44446542
134positive regulation of protein sumoylation (GO:0033235)2.40145827
135protein K11-linked deubiquitination (GO:0035871)2.39274431
136cytoplasmic mRNA processing body assembly (GO:0033962)2.37630689
137receptor recycling (GO:0001881)2.36562132
138positive T cell selection (GO:0043368)2.35798236
139facial nerve structural organization (GO:0021612)2.35636097
140phosphatidylinositol dephosphorylation (GO:0046856)2.35321152
141regulation of NFAT protein import into nucleus (GO:0051532)2.35194930
142regulation of translation, ncRNA-mediated (GO:0045974)2.34957664
143negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.34957664
144negative regulation of translation, ncRNA-mediated (GO:0040033)2.34957664
145establishment of mitochondrion localization (GO:0051654)2.34826235
146central nervous system neuron axonogenesis (GO:0021955)2.34825870
147neurotransmitter-gated ion channel clustering (GO:0072578)2.33652114
148regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.32785467
149positive regulation of gamma-delta T cell activation (GO:0046645)2.31911086
150negative regulation of meiosis (GO:0045835)2.31127204
151inositol phosphate catabolic process (GO:0071545)2.29388378
152regulation of action potential (GO:0098900)2.28167443
153axonal fasciculation (GO:0007413)2.26416006
154negative regulation of histone methylation (GO:0031061)2.24497781
155cranial nerve structural organization (GO:0021604)2.23794212
156pharyngeal system development (GO:0060037)2.21570427
157positive regulation of CREB transcription factor activity (GO:0032793)2.19835011
158DNA damage induced protein phosphorylation (GO:0006975)2.18559563
159positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.18539565
160protein-DNA complex disassembly (GO:0032986)2.18050512
161nucleosome disassembly (GO:0006337)2.18050512
162phosphatidylinositol phosphorylation (GO:0046854)2.17611919
163regulation of synaptic transmission, GABAergic (GO:0032228)2.16991602
164lipid phosphorylation (GO:0046834)2.16888220
165startle response (GO:0001964)2.15825261
166negative regulation of norepinephrine secretion (GO:0010700)2.14955170
167protein K48-linked deubiquitination (GO:0071108)2.14818754
168positive regulation of cell cycle checkpoint (GO:1901978)2.14628817
169cerebellum development (GO:0021549)2.13956952
170detection of calcium ion (GO:0005513)2.13790416
171regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.10661774
172negative regulation of protein tyrosine kinase activity (GO:0061099)2.09554202
173dentate gyrus development (GO:0021542)2.09368158
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.09079939
175regulation of mRNA splicing, via spliceosome (GO:0048024)2.09033103
176regulation of histone H3-K27 methylation (GO:0061085)2.08662089
177membrane depolarization during action potential (GO:0086010)2.08595733
178cell migration in hindbrain (GO:0021535)2.08530427
179histone H3 deacetylation (GO:0070932)2.07898694
180innervation (GO:0060384)2.06126113
181regulation of male gonad development (GO:2000018)2.05924252
182phospholipid dephosphorylation (GO:0046839)2.05783166
183activation of MAPKKK activity (GO:0000185)2.05301928
184demethylation (GO:0070988)2.04532991
185cell differentiation involved in kidney development (GO:0061005)2.03690584
186inner ear receptor cell differentiation (GO:0060113)2.03327365
187positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.03251930
188insulin-like growth factor receptor signaling pathway (GO:0048009)2.03161314
189vocalization behavior (GO:0071625)2.02259790
190peptidyl-lysine methylation (GO:0018022)2.01825296
191regulation of histone deacetylation (GO:0031063)2.00425164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76447088
2VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.68706627
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.37301092
4VDR_21846776_ChIP-Seq_THP-1_Human3.33432977
5GBX2_23144817_ChIP-Seq_PC3_Human3.30262430
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.13842565
7MYC_22102868_ChIP-Seq_BL_Human3.13192312
8KDM2B_26808549_Chip-Seq_SUP-B15_Human3.12984268
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.96788268
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.76737314
11KDM2B_26808549_Chip-Seq_DND41_Human2.71778368
12TCF7_22412390_ChIP-Seq_EML_Mouse2.68965146
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.66636893
14LXR_22292898_ChIP-Seq_THP-1_Human2.66585510
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.48185445
16DROSHA_22980978_ChIP-Seq_HELA_Human2.41650900
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41241240
18VDR_24763502_ChIP-Seq_THP-1_Human2.27069411
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.22989655
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.22014326
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.19827488
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16782699
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16695861
24MAF_26560356_Chip-Seq_TH1_Human2.16267861
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14442065
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12740395
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11949874
28UTX_26944678_Chip-Seq_JUKART_Human2.02414263
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.95735689
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.93209754
31KDM2B_26808549_Chip-Seq_K562_Human1.92429540
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92277469
33MAF_26560356_Chip-Seq_TH2_Human1.86557603
34TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.83423423
35AR_21572438_ChIP-Seq_LNCaP_Human1.83140419
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79741400
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.77324282
38AHR_22903824_ChIP-Seq_MCF-7_Human1.77221595
39SPI1_23127762_ChIP-Seq_K562_Human1.77190195
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.74863814
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73818064
42RACK7_27058665_Chip-Seq_MCF-7_Human1.72427160
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.72417145
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71319125
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70731948
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70117207
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68846456
48P68_20966046_ChIP-Seq_HELA_Human1.67895167
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.67331345
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65661034
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.65515033
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64941975
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.64733284
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64317148
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62252054
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.61073679
57CIITA_25753668_ChIP-Seq_RAJI_Human1.60356370
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59956655
59STAT3_23295773_ChIP-Seq_U87_Human1.59442189
60SMC4_20622854_ChIP-Seq_HELA_Human1.59339945
61TCF4_23295773_ChIP-Seq_U87_Human1.59095062
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57909390
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.57419585
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54317051
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54317051
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51252436
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51210449
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.50509432
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49261869
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49075148
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48944273
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46667181
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45056014
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44644701
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43158279
76SMAD4_21799915_ChIP-Seq_A2780_Human1.43040814
77RUNX_20019798_ChIP-Seq_JUKART_Human1.42322029
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.42033930
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40376240
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38674385
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.37855856
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37137220
83BCOR_27268052_Chip-Seq_Bcells_Human1.35964789
84CREB1_26743006_Chip-Seq_LNCaP_Human1.35666841
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.35570468
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33760576
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32281662
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31686351
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31508647
90BCL6_27268052_Chip-Seq_Bcells_Human1.31233690
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29423510
92IRF8_27001747_Chip-Seq_BMDM_Mouse1.29087448
93GATA1_19941826_ChIP-Seq_K562_Human1.28244461
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.27774008
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.26032950
96GATA1_22025678_ChIP-Seq_K562_Human1.25836153
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25691961
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24802017
99MYB_26560356_Chip-Seq_TH1_Human1.22864988
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22212913
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21543935
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21088482
103FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.20759645
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20367411
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.19749123
106MYB_26560356_Chip-Seq_TH2_Human1.19691160
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19604304
108JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19319811
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19307613
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19249545
111AR_19668381_ChIP-Seq_PC3_Human1.19224738
112EZH2_27304074_Chip-Seq_ESCs_Mouse1.17904498
113IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17480542
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17476441
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16174981
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16002087
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15783688
118TP53_16413492_ChIP-PET_HCT116_Human1.15176905
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14995375
120NCOR1_26117541_ChIP-Seq_K562_Human1.14806352
121RUNX1_27514584_Chip-Seq_MCF-7_Human1.14483740
122POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14068122
123TET1_21451524_ChIP-Seq_MESCs_Mouse1.13679327
124EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13533436
125RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13533436
126ESR1_20079471_ChIP-ChIP_T-47D_Human1.13292757
127PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12481108
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.10822567
129JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10787646
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10730389
131EWS_26573619_Chip-Seq_HEK293_Human1.10580837
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10249980
133MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09903114
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08720632
135STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07864456
136EED_16625203_ChIP-ChIP_MESCs_Mouse1.07217805
137CTCF_27219007_Chip-Seq_Bcells_Human1.07028720
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06981902
139GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06804554
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06481045
141SOX2_21211035_ChIP-Seq_LN229_Gbm1.05840952
142FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05824671
143PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05748939
144IRF8_21731497_ChIP-ChIP_J774_Mouse1.05725121
145SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05311205
146OCT4_19829295_ChIP-Seq_ESCs_Human1.05114655
147PIAS1_25552417_ChIP-Seq_VCAP_Human1.05021398
148ERG_21242973_ChIP-ChIP_JURKAT_Human1.04676435
149AR_25329375_ChIP-Seq_VCAP_Human1.04561535
150TP63_22573176_ChIP-Seq_HFKS_Human1.04366263
151REST_21632747_ChIP-Seq_MESCs_Mouse1.04149014
152MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03933211
153IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03535336
154PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02685833
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02329034
156LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02287936
157SPI1_23547873_ChIP-Seq_NB4_Human1.02195884
158ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01730372
159P300_19829295_ChIP-Seq_ESCs_Human1.01206537
160UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01075808
161CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00771857
162TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00495057
163ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00062000
164TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99356484
165E2F1_20622854_ChIP-Seq_HELA_Human0.99192124
166RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97953120
167STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97797305
168TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97785053
169RUNX2_22187159_ChIP-Seq_PCA_Human0.97715581
170RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97401129
171ISL1_27105846_Chip-Seq_CPCs_Mouse0.97151043
172TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96953145
173SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96341797
174TP63_19390658_ChIP-ChIP_HaCaT_Human0.96161174
175SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95820444
176RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94974655
177SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94737091
178SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94433230
179SOX9_26525672_Chip-Seq_HEART_Mouse0.93563821
180NANOG_18555785_Chip-Seq_ESCs_Mouse0.93353425
181OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92917674
182SCL_19346495_ChIP-Seq_HPC-7_Human0.92727512
183SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91492607
184SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91426663
185SMAD3_21741376_ChIP-Seq_ESCs_Human0.91423210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.59454004
2MP0003436_decreased_susceptibility_to3.91550126
3MP0003303_peritoneal_inflammation3.44190909
4MP0003724_increased_susceptibility_to3.00282763
5MP0000569_abnormal_digit_pigmentation2.89282132
6MP0003183_abnormal_peptide_metabolism2.85500840
7MP0009278_abnormal_bone_marrow2.84572105
8MP0008260_abnormal_autophagy2.57423751
9MP0001800_abnormal_humoral_immune2.41897699
10MP0003121_genomic_imprinting2.41010248
11MP0000015_abnormal_ear_pigmentation2.39224715
12MP0005646_abnormal_pituitary_gland2.39097461
13MP0000685_abnormal_immune_system2.36651927
14MP0001835_abnormal_antigen_presentation2.36414860
15MP0005387_immune_system_phenotype2.29284335
16MP0001790_abnormal_immune_system2.29284335
17MP0005451_abnormal_body_composition2.27601667
18MP0004859_abnormal_synaptic_plasticity2.25178538
19MP0002419_abnormal_innate_immunity2.20910374
20MP0005025_abnormal_response_to2.20888032
21MP0005000_abnormal_immune_tolerance2.16781258
22MP0009780_abnormal_chondrocyte_physiolo2.13821019
23MP0005076_abnormal_cell_differentiation2.12657051
24MP0005671_abnormal_response_to2.09916335
25MP0005394_taste/olfaction_phenotype2.06494924
26MP0005499_abnormal_olfactory_system2.06494924
27MP0003300_gastrointestinal_ulcer2.05514440
28MP0004381_abnormal_hair_follicle2.05439143
29MP0003705_abnormal_hypodermis_morpholog2.04876513
30MP0002420_abnormal_adaptive_immunity2.01755446
31MP0002723_abnormal_immune_serum1.99990192
32MP0010386_abnormal_urinary_bladder1.99888042
33MP0001819_abnormal_immune_cell1.99489909
34MP0004043_abnormal_pH_regulation1.89552973
35MP0000778_abnormal_nervous_system1.86900195
36MP0002452_abnormal_antigen_presenting1.86689443
37MP0002396_abnormal_hematopoietic_system1.83812589
38MP0005645_abnormal_hypothalamus_physiol1.82888407
39MP0004130_abnormal_muscle_cell1.80249297
40MP0008789_abnormal_olfactory_epithelium1.78994382
41MP0004947_skin_inflammation1.76281333
42MP0001533_abnormal_skeleton_physiology1.74596911
43MP0002398_abnormal_bone_marrow1.70836086
44MP0005058_abnormal_lysosome_morphology1.70806210
45MP0003635_abnormal_synaptic_transmissio1.64956653
46MP0000716_abnormal_immune_system1.62472183
47MP0000703_abnormal_thymus_morphology1.60493463
48MP0009333_abnormal_splenocyte_physiolog1.57480166
49MP0002822_catalepsy1.57046138
50MP0002405_respiratory_system_inflammati1.55159436
51MP0004885_abnormal_endolymph1.54462669
52MP0004134_abnormal_chest_morphology1.53880026
53MP0004858_abnormal_nervous_system1.51480817
54MP0008058_abnormal_DNA_repair1.49549300
55MP0003866_abnormal_defecation1.49248873
56MP0001348_abnormal_lacrimal_gland1.49200548
57MP0001188_hyperpigmentation1.47482432
58MP0003828_pulmonary_edema1.45864884
59MP0009785_altered_susceptibility_to1.45137017
60MP0003122_maternal_imprinting1.43951554
61MP0002249_abnormal_larynx_morphology1.43702460
62MP0004742_abnormal_vestibular_system1.43189216
63MP0000631_abnormal_neuroendocrine_gland1.42161658
64MP0000003_abnormal_adipose_tissue1.41988234
65MP0003123_paternal_imprinting1.41823792
66MP0005397_hematopoietic_system_phenotyp1.41645287
67MP0001545_abnormal_hematopoietic_system1.41645287
68MP0008569_lethality_at_weaning1.40253410
69MP0004808_abnormal_hematopoietic_stem1.38880950
70MP0003191_abnormal_cellular_cholesterol1.38448444
71MP0010155_abnormal_intestine_physiology1.37441659
72MP0008007_abnormal_cellular_replicative1.36261656
73MP0005423_abnormal_somatic_nervous1.35108049
74MP0002722_abnormal_immune_system1.33282758
75MP0004510_myositis1.32802394
76MP0005367_renal/urinary_system_phenotyp1.32368270
77MP0000516_abnormal_urinary_system1.32368270
78MP0001984_abnormal_olfaction1.31814826
79MP0004147_increased_porphyrin_level1.31394268
80MP0002933_joint_inflammation1.31058391
81MP0001502_abnormal_circadian_rhythm1.30705516
82MP0002998_abnormal_bone_remodeling1.29850665
83MP0009745_abnormal_behavioral_response1.27305062
84MP0001177_atelectasis1.27249312
85MP0002429_abnormal_blood_cell1.26136780
86MP0000689_abnormal_spleen_morphology1.26109053
87MP0002184_abnormal_innervation1.25394650
88MP0005171_absent_coat_pigmentation1.24954218
89MP0002877_abnormal_melanocyte_morpholog1.23054738
90MP0004270_analgesia1.22293511
91MP0006292_abnormal_olfactory_placode1.21595780
92MP0005464_abnormal_platelet_physiology1.21588854
93MP0008877_abnormal_DNA_methylation1.20802469
94MP0001486_abnormal_startle_reflex1.20781907
95MP0005409_darkened_coat_color1.19427360
96MP0001270_distended_abdomen1.19013122
97MP0003091_abnormal_cell_migration1.17332773
98MP0005666_abnormal_adipose_tissue1.16868866
99MP0004185_abnormal_adipocyte_glucose1.13206538
100MP0005174_abnormal_tail_pigmentation1.13031968
101MP0009703_decreased_birth_body1.12941431
102MP0003385_abnormal_body_wall1.12516351
103MP0002063_abnormal_learning/memory/cond1.12385653
104MP0006082_CNS_inflammation1.11937324
105MP0002572_abnormal_emotion/affect_behav1.10143402
106MP0001849_ear_inflammation1.10037804
107MP0000537_abnormal_urethra_morphology1.09230382
108MP0001873_stomach_inflammation1.05819248
109MP0002148_abnormal_hypersensitivity_rea1.04671151
110MP0005377_hearing/vestibular/ear_phenot1.04410002
111MP0003878_abnormal_ear_physiology1.04410002
112MP0002751_abnormal_autonomic_nervous1.04383961
113MP0006072_abnormal_retinal_apoptosis1.03823467
114MP0005310_abnormal_salivary_gland1.03165277
115MP0002095_abnormal_skin_pigmentation1.03078432
116MP0002132_abnormal_respiratory_system1.03067986
117MP0001845_abnormal_inflammatory_respons1.02621855
118MP0002909_abnormal_adrenal_gland1.02498086
119MP0005253_abnormal_eye_physiology1.01536713
120MP0004811_abnormal_neuron_physiology1.01398303
121MP0003763_abnormal_thymus_physiology1.00637671
122MP0001851_eye_inflammation1.00059686
123MP0003690_abnormal_glial_cell0.99900047
124MP0000751_myopathy0.99887853
125MP0003861_abnormal_nervous_system0.99750893
126MP0002557_abnormal_social/conspecific_i0.98511231
127MP0002152_abnormal_brain_morphology0.98246170
128MP0000013_abnormal_adipose_tissue0.97450486
129MP0005375_adipose_tissue_phenotype0.97253358
130MP0002882_abnormal_neuron_morphology0.96625767
131MP0002653_abnormal_ependyma_morphology0.96362821
132MP0002067_abnormal_sensory_capabilities0.96090079
133MP0003115_abnormal_respiratory_system0.95956507
134MP0000465_gastrointestinal_hemorrhage0.95009362
135MP0000534_abnormal_ureter_morphology0.94714049
136MP0000955_abnormal_spinal_cord0.94134791
137MP0008961_abnormal_basal_metabolism0.94104741
138MP0003632_abnormal_nervous_system0.93168356
139MP0005075_abnormal_melanosome_morpholog0.93139528
140MP0003880_abnormal_central_pattern0.92720126
141MP0003942_abnormal_urinary_system0.92532445
142MP0005551_abnormal_eye_electrophysiolog0.92108864
143MP0003879_abnormal_hair_cell0.91756401
144MP0003045_fibrosis0.90695247
145MP0002938_white_spotting0.89480255
146MP0002009_preneoplasia0.85889564
147MP0001186_pigmentation_phenotype0.85678447
148MP0002064_seizures0.85410401
149MP0003172_abnormal_lysosome_physiology0.84411881
150MP0005390_skeleton_phenotype0.83973933
151MP0003279_aneurysm0.83577165
152MP0004924_abnormal_behavior0.83505018
153MP0005386_behavior/neurological_phenoty0.83505018
154MP0002638_abnormal_pupillary_reflex0.83249476
155MP0000733_abnormal_muscle_development0.82745327
156MP0003890_abnormal_embryonic-extraembry0.82626043
157MP0002272_abnormal_nervous_system0.82315429
158MP0005220_abnormal_exocrine_pancreas0.80843895
159MP0002734_abnormal_mechanical_nocicepti0.79989824
160MP0008469_abnormal_protein_level0.79375044
161MP0000858_altered_metastatic_potential0.79118523
162MP0003935_abnormal_craniofacial_develop0.78955350
163MP0000759_abnormal_skeletal_muscle0.78500660
164MP0000749_muscle_degeneration0.78297020
165MP0000747_muscle_weakness0.78070242
166MP0001958_emphysema0.77057733
167MP0003943_abnormal_hepatobiliary_system0.76467910
168MP0000678_abnormal_parathyroid_gland0.75775913
169MP0005670_abnormal_white_adipose0.75092912
170MP0008874_decreased_physiological_sensi0.74746881
171MP0002928_abnormal_bile_duct0.74508416
172MP0001324_abnormal_eye_pigmentation0.73959771
173MP0002229_neurodegeneration0.73187915
174MP0002735_abnormal_chemical_nociception0.73148971
175MP0008995_early_reproductive_senescence0.72855585
176MP0009115_abnormal_fat_cell0.71786636
177MP0003656_abnormal_erythrocyte_physiolo0.71730146
178MP0003646_muscle_fatigue0.71165997
179MP0002081_perinatal_lethality0.71140068
180MP0010630_abnormal_cardiac_muscle0.70997963
181MP0002177_abnormal_outer_ear0.70831310
182MP0004087_abnormal_muscle_fiber0.70612306
183MP0005391_vision/eye_phenotype0.69607153
184MP0002166_altered_tumor_susceptibility0.69191670
185MP0003329_amyloid_beta_deposits0.68006153
186MP0000767_abnormal_smooth_muscle0.66614947
187MP0001663_abnormal_digestive_system0.65762431
188MP0000249_abnormal_blood_vessel0.65478663
189MP0004883_abnormal_blood_vessel0.64016665

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)4.91051746
2Eczematoid dermatitis (HP:0000976)4.81561333
3Obstructive sleep apnea (HP:0002870)3.89386428
4Neoplasm of the adrenal cortex (HP:0100641)3.84604124
5Myositis (HP:0100614)3.62420500
6Hyperactive renin-angiotensin system (HP:0000841)3.53349037
7Recurrent abscess formation (HP:0002722)3.46134901
8Recurrent bacterial skin infections (HP:0005406)3.38604212
9Increased IgE level (HP:0003212)3.37885048
10Scanning speech (HP:0002168)3.27055202
11Hyperkalemia (HP:0002153)3.10681830
12Gastrointestinal infarctions (HP:0005244)3.01422368
13Orchitis (HP:0100796)3.00728171
14Abnormality of macrophages (HP:0004311)3.00072535
15Vertebral arch anomaly (HP:0008438)2.99213058
16Elevated erythrocyte sedimentation rate (HP:0003565)2.98223516
17Abnormality of the fingertips (HP:0001211)2.92782259
18Recurrent fungal infections (HP:0002841)2.88953134
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.86710357
20Broad face (HP:0000283)2.86615148
21Colitis (HP:0002583)2.86174043
22Mediastinal lymphadenopathy (HP:0100721)2.81367204
23Cellulitis (HP:0100658)2.78614228
24Gingivitis (HP:0000230)2.77595410
25Meningitis (HP:0001287)2.76554401
26Spontaneous hematomas (HP:0007420)2.70925876
27Febrile seizures (HP:0002373)2.67984352
28Retrobulbar optic neuritis (HP:0100654)2.65377839
29Optic neuritis (HP:0100653)2.65377839
30Obstructive lung disease (HP:0006536)2.63059999
31Chronic obstructive pulmonary disease (HP:0006510)2.63059999
32Recurrent gram-negative bacterial infections (HP:0005420)2.62042434
33Gastrointestinal inflammation (HP:0004386)2.61514565
34Papillary thyroid carcinoma (HP:0002895)2.60973050
35Exercise-induced myalgia (HP:0003738)2.58102052
36Intestinal atresia (HP:0011100)2.56867361
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.55185977
38Stomatitis (HP:0010280)2.55070712
39Bell-shaped thorax (HP:0001591)2.50589021
40Stomach cancer (HP:0012126)2.47908112
41Panhypogammaglobulinemia (HP:0003139)2.45698468
42Anteriorly placed anus (HP:0001545)2.44681823
43Genetic anticipation (HP:0003743)2.44664747
44Inflammation of the large intestine (HP:0002037)2.44219025
45Chest pain (HP:0100749)2.40312799
46Hyperaldosteronism (HP:0000859)2.34659289
47Difficulty running (HP:0009046)2.33995535
48Hypochromic anemia (HP:0001931)2.29290064
49Cystic liver disease (HP:0006706)2.28282654
50Prolonged bleeding time (HP:0003010)2.27785793
51Anal stenosis (HP:0002025)2.27715574
52Macroorchidism (HP:0000053)2.26888236
53Recurrent skin infections (HP:0001581)2.26340501
54Metaphyseal cupping (HP:0003021)2.26265298
55Asymmetric septal hypertrophy (HP:0001670)2.25242038
56Abnormality of renin-angiotensin system (HP:0000847)2.23624793
57Chronic mucocutaneous candidiasis (HP:0002728)2.22671038
58Recurrent cutaneous fungal infections (HP:0011370)2.22671038
59Glioma (HP:0009733)2.22599186
60Vasculitis (HP:0002633)2.21968868
61Blue irides (HP:0000635)2.21068895
62Pustule (HP:0200039)2.19348304
63Recurrent viral infections (HP:0004429)2.14966331
64Centrally nucleated skeletal muscle fibers (HP:0003687)2.14592142
65Abnormality of the corticospinal tract (HP:0002492)2.11741642
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.11158294
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.11158294
68Abnormal hair whorl (HP:0010721)2.09725515
69Emphysema (HP:0002097)2.09546372
70Urinary bladder sphincter dysfunction (HP:0002839)2.09218855
71Encephalitis (HP:0002383)2.08804328
72Abnormality of the columella (HP:0009929)2.08319176
73Papilledema (HP:0001085)2.04664759
74Gastrointestinal stroma tumor (HP:0100723)2.03504144
75Increased variability in muscle fiber diameter (HP:0003557)2.03409808
76Dislocated radial head (HP:0003083)2.03034462
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02791495
78Abnormality of chloride homeostasis (HP:0011422)2.01417646
79Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.96694319
80Easy fatigability (HP:0003388)1.96300947
81Increased connective tissue (HP:0009025)1.95676431
82Pulmonary infiltrates (HP:0002113)1.94547124
83Ulnar deviation of the wrist (HP:0003049)1.94367254
84Hyperacusis (HP:0010780)1.93433445
85Keratoconjunctivitis sicca (HP:0001097)1.93141535
86Long eyelashes (HP:0000527)1.90950337
87Abnormality of skeletal muscle fiber size (HP:0012084)1.90851764
88Abnormality of the radial head (HP:0003995)1.90523532
89Chronic bronchitis (HP:0004469)1.90375564
90Gaze-evoked nystagmus (HP:0000640)1.89035825
91Onion bulb formation (HP:0003383)1.88664732
92Agammaglobulinemia (HP:0004432)1.88167262
93Segmental peripheral demyelination/remyelination (HP:0003481)1.88112372
94Bowel diverticulosis (HP:0005222)1.88094224
95Restrictive lung disease (HP:0002091)1.87533612
96Aneurysm (HP:0002617)1.87013660
97Thin bony cortex (HP:0002753)1.86957337
98Absent frontal sinuses (HP:0002688)1.85994643
99Epistaxis (HP:0000421)1.85838793
100Muscle fiber splitting (HP:0003555)1.85483732
101Myopathic facies (HP:0002058)1.84797071
102Tented upper lip vermilion (HP:0010804)1.84715554
103EMG: neuropathic changes (HP:0003445)1.84696154
104Thoracic kyphosis (HP:0002942)1.84520475
105Hemorrhage of the eye (HP:0011885)1.83928325
106Hemoptysis (HP:0002105)1.83305125
107Long palpebral fissure (HP:0000637)1.83205913
108Ankle clonus (HP:0011448)1.83001410
109Impaired smooth pursuit (HP:0007772)1.82391035
110Protruding tongue (HP:0010808)1.81489212
111Elfin facies (HP:0004428)1.80985658
112Hepatoblastoma (HP:0002884)1.80087851
113Renovascular hypertension (HP:0100817)1.79702388
114Midline defect of the nose (HP:0004122)1.78898417
115True hermaphroditism (HP:0010459)1.78611461
116Disproportionate tall stature (HP:0001519)1.77501730
117Chronic hepatic failure (HP:0100626)1.77010457
118Annular pancreas (HP:0001734)1.76899912
119Severe visual impairment (HP:0001141)1.76890810
120Distal lower limb amyotrophy (HP:0008944)1.76561631
121Slow saccadic eye movements (HP:0000514)1.76534869
122Renal duplication (HP:0000075)1.76379739
123Dysostosis multiplex (HP:0000943)1.76041695
124Peritonitis (HP:0002586)1.75592739
125Highly arched eyebrow (HP:0002553)1.75162010
126Interstitial pulmonary disease (HP:0006530)1.75055353
127Abnormality of the thoracic spine (HP:0100711)1.75046562
128Hypochromic microcytic anemia (HP:0004840)1.73997229
129Neoplasm of the heart (HP:0100544)1.73833668
130Nephronophthisis (HP:0000090)1.73767514
131Obsessive-compulsive behavior (HP:0000722)1.72601191
132Broad palm (HP:0001169)1.72391814
133Hyporeflexia of lower limbs (HP:0002600)1.72309215
134Atonic seizures (HP:0010819)1.71376394
135Abnormality of the peritoneum (HP:0002585)1.71292869
136Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71169972
137Increased cerebral lipofuscin (HP:0011813)1.70029617
138Progressive cerebellar ataxia (HP:0002073)1.69611772
139Acne (HP:0001061)1.68992342
140Neoplasm of the adrenal gland (HP:0100631)1.68251810
141Supranuclear gaze palsy (HP:0000605)1.67783783
142Focal seizures (HP:0007359)1.66581582
143Hypothermia (HP:0002045)1.66342325
144Cerebral aneurysm (HP:0004944)1.66197073
145Keratoconjunctivitis (HP:0001096)1.66133883
146Abnormality of the carotid arteries (HP:0005344)1.65806358
147Sepsis (HP:0100806)1.65398248
148Diplopia (HP:0000651)1.65364979
149Abnormality of binocular vision (HP:0011514)1.65364979
150Osteomyelitis (HP:0002754)1.65274003
151Deep philtrum (HP:0002002)1.65136648
152Granulocytopenia (HP:0001913)1.64585821
153Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64540234
154Breast carcinoma (HP:0003002)1.63929171
155Hypergammaglobulinemia (HP:0010702)1.63892261
156Ectopic kidney (HP:0000086)1.63807032
157Abnormality of the endocardium (HP:0004306)1.63421376
158Abnormality of potassium homeostasis (HP:0011042)1.63383453
159Dysmetric saccades (HP:0000641)1.63200272
160Ectopic anus (HP:0004397)1.63120986
161Molar tooth sign on MRI (HP:0002419)1.62902134
162Abnormality of midbrain morphology (HP:0002418)1.62902134
163Overriding aorta (HP:0002623)1.62611298
164Abnormal drinking behavior (HP:0030082)1.60184143
165Polydipsia (HP:0001959)1.60184143
166Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59689264
167Short 4th metacarpal (HP:0010044)1.59689264
168Abnormality of the metopic suture (HP:0005556)1.59474584
169Abnormality of the intervertebral disk (HP:0005108)1.59182822
170Urinary urgency (HP:0000012)1.58617591
171Long nose (HP:0003189)1.58230435
172Flat cornea (HP:0007720)1.57432142
173Abnormality of the renal cortex (HP:0011035)1.56492828
174Hypokalemic alkalosis (HP:0001949)1.56402003
175Gastrointestinal atresia (HP:0002589)1.55742660
176Hypoplasia of the fovea (HP:0007750)1.55522054
177Aplasia/Hypoplasia of the fovea (HP:0008060)1.55522054
178Mask-like facies (HP:0000298)1.55430899
179Narrow forehead (HP:0000341)1.54474884
180Insomnia (HP:0100785)1.53150738
181Intestinal fistula (HP:0100819)1.52940934
182Pancreatic fibrosis (HP:0100732)1.52555841
183Truncal ataxia (HP:0002078)1.52542826
184Broad nasal tip (HP:0000455)1.52414352
185Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.52396477
186Volvulus (HP:0002580)1.52014896
187Thyroid carcinoma (HP:0002890)1.51257978
188Hypoplasia of the maxilla (HP:0000327)1.51140392
189Abnormality of the renal medulla (HP:0100957)1.50799526
190Aqueductal stenosis (HP:0002410)1.50207850
191Abnormality of the frontal sinuses (HP:0002687)1.49803910
192Lip pit (HP:0100267)1.49414821
193Hypokalemia (HP:0002900)1.49274975
194Abnormal rod and cone electroretinograms (HP:0008323)1.49210569
195Optic nerve coloboma (HP:0000588)1.48644543
196Aplasia/Hypoplasia of the macula (HP:0008059)1.48533328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.86380052
2TRIB33.66352018
3PRPF4B3.48388467
4SGK23.05718760
5ERN12.79531139
6NTRK32.52805993
7PASK2.49235187
8SGK32.43532974
9TNIK2.42367785
10FES2.37796675
11RIPK42.35436375
12AKT32.30165560
13SIK12.29160112
14MAP2K32.23166624
15SGK4942.19396808
16SGK2232.19396808
17PKN12.01173229
18PRKCH1.96047373
19SMG11.93448467
20ICK1.92104010
21TYK21.90189860
22EPHB11.86778322
23ERBB31.82910478
24MAPK131.76494134
25IRAK31.68418116
26WNK11.61335117
27IRAK41.59014118
28ZAP701.58491976
29SIK21.51805999
30NEK61.50640081
31BLK1.48150602
32TAOK11.47929745
33FGFR41.44779664
34PRKD31.43452153
35BRD41.40145994
36TXK1.39578557
37RPS6KA21.38947186
38RIPK11.37464927
39MARK11.31039190
40CSK1.30718079
41CDK121.30058552
42BTK1.29520617
43TTN1.26294157
44MARK31.25934365
45CLK11.24365927
46TBK11.24078957
47GRK61.22956778
48MAP3K111.20099856
49EPHA41.17855333
50CDC42BPA1.16773509
51MAP3K31.15032902
52MAP3K71.11608037
53TNK21.11401163
54MAP2K71.07562432
55YES11.05735512
56IRAK21.05293572
57MAPK121.05125004
58INSRR1.04399782
59JAK31.04345899
60CAMKK10.99571921
61KSR10.99423216
62EEF2K0.98000147
63TYRO30.96926152
64MAP3K20.93752034
65MAP4K10.93716248
66MARK20.92812118
67SGK10.92439816
68PTK60.92284759
69CASK0.92209651
70MAP3K10.91885932
71CSNK1A1L0.89661019
72BMPR1B0.87336538
73KSR20.86278186
74UHMK10.84860619
75MAPK70.83034129
76JAK20.81984746
77DYRK1B0.81642372
78CHUK0.80941431
79STK240.80276318
80MTOR0.80084015
81JAK10.80067366
82FGFR30.79465241
83MAPK110.78508306
84HIPK20.78185487
85BRSK10.77529271
86MAP3K60.77329082
87PDPK10.75866249
88WNK30.75733836
89LCK0.75276757
90RPS6KB10.74759250
91TRPM70.73110429
92RPS6KA60.72582507
93PDK10.72154745
94WNK40.70916080
95PAK60.69762515
96PRKD20.69333130
97MAPK150.67786742
98BRSK20.66281986
99TAOK30.65833922
100PINK10.65738829
101TAOK20.65672522
102CAMK1G0.65231661
103STK40.64605991
104CAMK40.62930496
105CAMK1D0.62888698
106KIT0.62461134
107LYN0.61408599
108MAP3K40.61278467
109CDK40.60436576
110CAMK10.59435257
111CSF1R0.58719499
112STK110.57763807
113MAPK80.57678636
114PLK30.57575742
115ATR0.56537647
116FGR0.54903219
117MAP2K60.54444768
118DYRK1A0.53896457
119NTRK20.53227913
120STK380.52635235
121MAP2K20.52286094
122ITK0.51112326
123IKBKB0.50880283
124PKN20.50378190
125GSK3B0.50093112
126SIK30.49834188
127CHEK20.49420628
128PAK30.49134882
129MAP3K140.48342794
130ATM0.48129415
131MAPK140.47775985
132MAP3K130.46075137
133LRRK20.45936320
134MAP2K40.45335563
135ALK0.45207067
136PLK20.44855037
137FYN0.44836480
138NME10.42134854
139BMX0.41635631
140EPHA30.40169799
141MELK0.39482951
142SYK0.37800716
143HCK0.37628082
144PRKDC0.37107783
145RPS6KC10.35280383
146RPS6KL10.35280383
147CSNK1G20.35224870
148RPS6KA30.35202698
149IKBKE0.34418610
150AKT10.33654605
151PRKAA20.33466278
152IRAK10.33341243
153RET0.32863608
154MAP3K100.32374432
155CDK10.32092442
156CDK20.31989936

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.16479950
2Type II diabetes mellitus_Homo sapiens_hsa049301.99870955
3Phosphatidylinositol signaling system_Homo sapiens_hsa040701.86422413
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81528375
5Other glycan degradation_Homo sapiens_hsa005111.69803762
6VEGF signaling pathway_Homo sapiens_hsa043701.65331237
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65231486
8Leishmaniasis_Homo sapiens_hsa051401.62169288
9Taste transduction_Homo sapiens_hsa047421.61434591
10Endometrial cancer_Homo sapiens_hsa052131.57311571
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48363546
12Circadian entrainment_Homo sapiens_hsa047131.47838961
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47810986
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43144036
15Insulin secretion_Homo sapiens_hsa049111.40738302
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39741178
17Inositol phosphate metabolism_Homo sapiens_hsa005621.34681863
18Non-homologous end-joining_Homo sapiens_hsa034501.34317974
19Long-term potentiation_Homo sapiens_hsa047201.33486013
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.33061565
21Primary immunodeficiency_Homo sapiens_hsa053401.31726513
22B cell receptor signaling pathway_Homo sapiens_hsa046621.23849147
23Notch signaling pathway_Homo sapiens_hsa043301.23493681
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23385568
25Lysine degradation_Homo sapiens_hsa003101.23181716
26Measles_Homo sapiens_hsa051621.22759221
27Morphine addiction_Homo sapiens_hsa050321.22128681
28T cell receptor signaling pathway_Homo sapiens_hsa046601.21068304
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20469798
30Fanconi anemia pathway_Homo sapiens_hsa034601.19969768
31Axon guidance_Homo sapiens_hsa043601.19885269
32TNF signaling pathway_Homo sapiens_hsa046681.19577198
33Glutamatergic synapse_Homo sapiens_hsa047241.19188738
34Tuberculosis_Homo sapiens_hsa051521.18053193
35Renal cell carcinoma_Homo sapiens_hsa052111.17135888
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13767006
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12917267
38Toxoplasmosis_Homo sapiens_hsa051451.12780242
39Influenza A_Homo sapiens_hsa051641.12077122
40Hepatitis B_Homo sapiens_hsa051611.11743022
41Staphylococcus aureus infection_Homo sapiens_hsa051501.10754775
42Olfactory transduction_Homo sapiens_hsa047401.10085701
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08711411
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07770358
45Hepatitis C_Homo sapiens_hsa051601.07280764
46ErbB signaling pathway_Homo sapiens_hsa040121.07120127
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06445785
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.06151732
49mRNA surveillance pathway_Homo sapiens_hsa030151.05904724
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.05031115
51Prolactin signaling pathway_Homo sapiens_hsa049171.04416946
52Nicotine addiction_Homo sapiens_hsa050331.03528692
53Circadian rhythm_Homo sapiens_hsa047101.01298778
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01140201
55Dilated cardiomyopathy_Homo sapiens_hsa054141.00513918
56Dorso-ventral axis formation_Homo sapiens_hsa043201.00513222
57Platelet activation_Homo sapiens_hsa046110.98950691
58Cholinergic synapse_Homo sapiens_hsa047250.97876710
59Graft-versus-host disease_Homo sapiens_hsa053320.96902464
60Non-small cell lung cancer_Homo sapiens_hsa052230.96618329
61Malaria_Homo sapiens_hsa051440.95580007
62Colorectal cancer_Homo sapiens_hsa052100.95480256
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95428813
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.93595109
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.92497688
66FoxO signaling pathway_Homo sapiens_hsa040680.91222932
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91193028
68Herpes simplex infection_Homo sapiens_hsa051680.89138067
69Gastric acid secretion_Homo sapiens_hsa049710.88439244
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87524749
71cAMP signaling pathway_Homo sapiens_hsa040240.86741310
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86667036
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86478313
74Chronic myeloid leukemia_Homo sapiens_hsa052200.86053203
75Calcium signaling pathway_Homo sapiens_hsa040200.86043960
76MAPK signaling pathway_Homo sapiens_hsa040100.85760826
77Dopaminergic synapse_Homo sapiens_hsa047280.84243323
78Allograft rejection_Homo sapiens_hsa053300.83855173
79Cocaine addiction_Homo sapiens_hsa050300.83536990
80Autoimmune thyroid disease_Homo sapiens_hsa053200.82405823
81Oxytocin signaling pathway_Homo sapiens_hsa049210.80764420
82Viral myocarditis_Homo sapiens_hsa054160.80059886
83GnRH signaling pathway_Homo sapiens_hsa049120.79797862
84GABAergic synapse_Homo sapiens_hsa047270.79128237
85Amphetamine addiction_Homo sapiens_hsa050310.79031709
86Phototransduction_Homo sapiens_hsa047440.78987608
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78879771
88Long-term depression_Homo sapiens_hsa047300.78637251
89Endocytosis_Homo sapiens_hsa041440.78458186
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77898970
91ABC transporters_Homo sapiens_hsa020100.77764380
92Renin secretion_Homo sapiens_hsa049240.76430330
93Chemokine signaling pathway_Homo sapiens_hsa040620.76214450
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.74262298
95AMPK signaling pathway_Homo sapiens_hsa041520.74183924
96Serotonergic synapse_Homo sapiens_hsa047260.73945931
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.73711698
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73610719
99Alcoholism_Homo sapiens_hsa050340.73437383
100Prostate cancer_Homo sapiens_hsa052150.73028098
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72845056
102Choline metabolism in cancer_Homo sapiens_hsa052310.72268297
103Insulin signaling pathway_Homo sapiens_hsa049100.71986819
104Hematopoietic cell lineage_Homo sapiens_hsa046400.71927018
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71109434
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70740402
107Wnt signaling pathway_Homo sapiens_hsa043100.70202391
108Apoptosis_Homo sapiens_hsa042100.70114789
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.69379096
110Estrogen signaling pathway_Homo sapiens_hsa049150.67754426
111Glioma_Homo sapiens_hsa052140.67356202
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65656323
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65513074
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65404520
115MicroRNAs in cancer_Homo sapiens_hsa052060.65276087
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.65202491
117Acute myeloid leukemia_Homo sapiens_hsa052210.64850689
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63870164
119Bladder cancer_Homo sapiens_hsa052190.63590813
120Rap1 signaling pathway_Homo sapiens_hsa040150.63099775
121Salivary secretion_Homo sapiens_hsa049700.62500406
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61737055
123Viral carcinogenesis_Homo sapiens_hsa052030.61558683
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61402462
125Insulin resistance_Homo sapiens_hsa049310.61364308
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60985660
127Amoebiasis_Homo sapiens_hsa051460.60408565
128Basal cell carcinoma_Homo sapiens_hsa052170.60020016
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.59953919
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59483398
131HIF-1 signaling pathway_Homo sapiens_hsa040660.58498858
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57946918
133mTOR signaling pathway_Homo sapiens_hsa041500.57883243
134Pancreatic cancer_Homo sapiens_hsa052120.57844120
135Melanogenesis_Homo sapiens_hsa049160.56669943
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.56464509
137HTLV-I infection_Homo sapiens_hsa051660.55416118
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.54470673
139Adherens junction_Homo sapiens_hsa045200.53558053
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.53506825
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52768994
142Synaptic vesicle cycle_Homo sapiens_hsa047210.52309549
143Pertussis_Homo sapiens_hsa051330.52129998
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50401033
145African trypanosomiasis_Homo sapiens_hsa051430.49963662
146Focal adhesion_Homo sapiens_hsa045100.49833023

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