MAX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.97565734
2neutrophil activation (GO:0042119)4.19230432
3regulation of platelet aggregation (GO:0090330)4.06550417
4thrombin receptor signaling pathway (GO:0070493)4.00674057
5positive regulation of mast cell activation (GO:0033005)3.96018039
6negative regulation of erythrocyte differentiation (GO:0045647)3.93092184
7leukocyte migration involved in inflammatory response (GO:0002523)3.85514444
8granulocyte activation (GO:0036230)3.82796214
9detection of other organism (GO:0098543)3.68941768
10positive regulation of B cell differentiation (GO:0045579)3.63441294
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58769654
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58769654
13detection of bacterium (GO:0016045)3.57975168
14response to peptidoglycan (GO:0032494)3.57968596
15regulation of mast cell degranulation (GO:0043304)3.53275170
16cellular extravasation (GO:0045123)3.45500507
17macrophage activation involved in immune response (GO:0002281)3.43244671
18G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.41061854
19cytoplasmic mRNA processing body assembly (GO:0033962)3.39438344
20myeloid cell activation involved in immune response (GO:0002275)3.37812603
21regulation of platelet activation (GO:0010543)3.33725836
22megakaryocyte development (GO:0035855)3.29156501
23response to host immune response (GO:0052572)3.28177473
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.28177473
25microglial cell activation (GO:0001774)3.26307751
26regulation of mast cell activation involved in immune response (GO:0033006)3.25570735
27negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.22918799
283-UTR-mediated mRNA stabilization (GO:0070935)3.21505031
29leukocyte degranulation (GO:0043299)3.19044537
30regulation of mast cell activation (GO:0033003)3.18963832
31positive regulation of gamma-delta T cell activation (GO:0046645)3.13767272
32regulation of RNA export from nucleus (GO:0046831)3.12985195
33positive regulation of histone deacetylation (GO:0031065)3.12370950
34mitotic sister chromatid cohesion (GO:0007064)3.12266599
35antigen processing and presentation of endogenous antigen (GO:0019883)3.11200478
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.10899067
37angiogenesis involved in wound healing (GO:0060055)3.10816848
38regulation of regulatory T cell differentiation (GO:0045589)3.10721611
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.09700022
40positive regulation of macrophage differentiation (GO:0045651)3.09491379
41regulation of leukocyte degranulation (GO:0043300)3.09305040
42antigen processing and presentation via MHC class Ib (GO:0002475)3.08657519
43negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08182762
44negative regulation of T-helper cell differentiation (GO:0045623)3.08182762
45positive regulation of lamellipodium assembly (GO:0010592)3.07088236
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05780925
47response to host (GO:0075136)3.05780925
48response to host defenses (GO:0052200)3.05780925
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05691762
50detection of external biotic stimulus (GO:0098581)3.05248895
51trophectodermal cell differentiation (GO:0001829)3.04235299
52regulation of interleukin-12 biosynthetic process (GO:0045075)3.03993431
53mRNA stabilization (GO:0048255)3.03650233
54RNA stabilization (GO:0043489)3.03650233
55platelet aggregation (GO:0070527)3.02339911
56negative regulation of T cell mediated immunity (GO:0002710)3.01209598
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00126331
58negative regulation of cell killing (GO:0031342)3.00126331
59regulation of gamma-delta T cell differentiation (GO:0045586)2.99566000
60lipoxygenase pathway (GO:0019372)2.98560623
61response to interleukin-15 (GO:0070672)2.98095162
62dendritic cell chemotaxis (GO:0002407)2.97115714
63pre-miRNA processing (GO:0031054)2.95927404
64adenosine receptor signaling pathway (GO:0001973)2.95858193
65regulation of B cell differentiation (GO:0045577)2.95107471
66positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94478623
67regulation of alpha-beta T cell proliferation (GO:0046640)2.93200096
68NLS-bearing protein import into nucleus (GO:0006607)2.90215966
69negative regulation of leukocyte mediated immunity (GO:0002704)2.90114035
70Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89830410
71negative regulation of histone methylation (GO:0031061)2.89228171
72regulation of natural killer cell mediated immunity (GO:0002715)2.88884891
73regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88884891
74T cell migration (GO:0072678)2.88360832
75G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.86758113
76positive regulation of mast cell activation involved in immune response (GO:0033008)2.86020943
77positive regulation of mast cell degranulation (GO:0043306)2.86020943
78regulation of T-helper 2 cell differentiation (GO:0045628)2.84218466
79regulation of interferon-beta biosynthetic process (GO:0045357)2.81153895
80germinal center formation (GO:0002467)2.80887850
81positive regulation by symbiont of host defense response (GO:0052509)2.80772847
82modulation by symbiont of host defense response (GO:0052031)2.80772847
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80772847
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80772847
85positive regulation by organism of defense response of other organism involved in symbiotic interact2.80772847
86modulation by symbiont of host immune response (GO:0052553)2.80772847
87T cell selection (GO:0045058)2.80229734
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79225006
89mitotic nuclear envelope disassembly (GO:0007077)2.78361439
90negative regulation of homotypic cell-cell adhesion (GO:0034111)2.76629459
91mast cell activation (GO:0045576)2.76421768
92nuclear pore complex assembly (GO:0051292)2.76369631
93detection of molecule of bacterial origin (GO:0032490)2.75913660
94positive regulation of B cell mediated immunity (GO:0002714)2.73392545
95positive regulation of immunoglobulin mediated immune response (GO:0002891)2.73392545
96macrophage activation (GO:0042116)2.72384418
97positive regulation of isotype switching (GO:0045830)2.72381099
98glucocorticoid receptor signaling pathway (GO:0042921)2.71001843
99positive thymic T cell selection (GO:0045059)2.69882106
100leukocyte aggregation (GO:0070486)2.69276094
101regulation of protein heterodimerization activity (GO:0043497)2.68688079
102regulation of nucleobase-containing compound transport (GO:0032239)2.67639750
103dendritic cell migration (GO:0036336)2.67635538
104negative regulation of interleukin-17 production (GO:0032700)2.67166575
105hepatocyte apoptotic process (GO:0097284)2.67100980
106T cell apoptotic process (GO:0070231)2.66757542
107response to muramyl dipeptide (GO:0032495)2.66669761
108positive regulation of lamellipodium organization (GO:1902745)2.65974897
109cellular response to type I interferon (GO:0071357)2.65081511
110type I interferon signaling pathway (GO:0060337)2.65081511
111membrane disassembly (GO:0030397)2.63624970
112nuclear envelope disassembly (GO:0051081)2.63624970
113corticosteroid receptor signaling pathway (GO:0031958)2.61541596
114regulation of gamma-delta T cell activation (GO:0046643)2.59086099
115regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57983270
116regulation of translational fidelity (GO:0006450)2.57959449
117heterochromatin organization (GO:0070828)2.55947722
118immunoglobulin mediated immune response (GO:0016064)2.54895453
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52806847
120actin nucleation (GO:0045010)2.50489967
121embryonic process involved in female pregnancy (GO:0060136)2.50190980
122establishment of endothelial barrier (GO:0061028)2.48848523
123nuclear pore organization (GO:0006999)2.47598579
124regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.46017620
125positive regulation of gene expression, epigenetic (GO:0045815)2.44149445
126positive regulation of SMAD protein import into nucleus (GO:0060391)2.43808022
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.41549263
128regulation of sister chromatid cohesion (GO:0007063)2.41383225
129nuclear envelope organization (GO:0006998)2.39991041
130regulation of early endosome to late endosome transport (GO:2000641)2.38909787
131regulation of B cell receptor signaling pathway (GO:0050855)2.38440141
132folic acid-containing compound biosynthetic process (GO:0009396)2.38237171
133JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.38218142
134cytokinetic process (GO:0032506)2.37712829
135histone H2A monoubiquitination (GO:0035518)2.37097580
136positive regulation of protein deacetylation (GO:0090312)2.37094624
137thymic T cell selection (GO:0045061)2.36888377
138DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.36724186
139lymphocyte apoptotic process (GO:0070227)2.36044201
140natural killer cell differentiation (GO:0001779)2.35608558
141response to UV-C (GO:0010225)2.34775758
142intracellular estrogen receptor signaling pathway (GO:0030520)2.34145230
143apoptotic process involved in morphogenesis (GO:0060561)2.32285637
144regulation of integrin activation (GO:0033623)2.31687265
145regulation of RNA stability (GO:0043487)2.30880281
146regulation of mRNA stability (GO:0043488)2.30813570
147embryonic hemopoiesis (GO:0035162)2.30778319
148tolerance induction (GO:0002507)2.28866337
149mitotic chromosome condensation (GO:0007076)2.28417436
150response to laminar fluid shear stress (GO:0034616)2.27360659
151protein localization to kinetochore (GO:0034501)2.26642882
152positive regulation of erythrocyte differentiation (GO:0045648)2.25195684
153negative regulation of interleukin-12 production (GO:0032695)2.24132393
154nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.23400802
155regulation of spindle organization (GO:0090224)2.23290292
156endothelial tube morphogenesis (GO:0061154)2.23135807
157morphogenesis of an endothelium (GO:0003159)2.23135807
158histone mRNA catabolic process (GO:0071044)2.21856108
159B cell mediated immunity (GO:0019724)2.21506301
160positive regulation of interferon-alpha production (GO:0032727)2.21459316
161positive regulation of granulocyte differentiation (GO:0030854)2.21118875
162regulation of erythrocyte differentiation (GO:0045646)2.20769414
163negative thymic T cell selection (GO:0045060)2.19792478
164protein localization to endosome (GO:0036010)2.19160334
165leukocyte cell-cell adhesion (GO:0007159)2.19061046
166negative regulation of RNA splicing (GO:0033119)2.17429066
167B cell receptor signaling pathway (GO:0050853)2.17258162
168negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.16265720
169negative T cell selection (GO:0043383)2.15955716
170germ cell migration (GO:0008354)2.15866368
171regulation of mitotic spindle organization (GO:0060236)2.15270297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.39396762
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.01719151
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.82675756
4MYC_22102868_ChIP-Seq_BL_Human3.76553147
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.28306383
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14633878
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00275812
8VDR_21846776_ChIP-Seq_THP-1_Human2.65398906
9* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.54668374
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.50788939
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.48031653
12TCF7_22412390_ChIP-Seq_EML_Mouse2.34498899
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19266029
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16575110
15MAF_26560356_Chip-Seq_TH1_Human2.15120109
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.14325589
17LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.11308524
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08996418
19GATA1_19941826_ChIP-Seq_K562_Human2.08995423
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08750100
21* UTX_26944678_Chip-Seq_JUKART_Human2.08678431
22KDM2B_26808549_Chip-Seq_DND41_Human2.07746936
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05996029
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98817108
25* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96259894
26MYB_26560356_Chip-Seq_TH2_Human1.96242489
27* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.92507568
28* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88254687
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86870805
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.86762454
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85520166
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84725783
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82994015
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.79306333
35MYB_26560356_Chip-Seq_TH1_Human1.77633014
36* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75369756
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72920118
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72034028
39SCL_19346495_ChIP-Seq_HPC-7_Human1.70963816
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.70451775
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.69156183
42GATA2_19941826_ChIP-Seq_K562_Human1.67164620
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66580473
44* VDR_24763502_ChIP-Seq_THP-1_Human1.66026735
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59624930
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.58092936
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57585531
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57315615
49* IRF8_27001747_Chip-Seq_BMDM_Mouse1.54436602
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.53134626
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52024613
52GATA1_22025678_ChIP-Seq_K562_Human1.51941093
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50887166
54RUNX_20019798_ChIP-Seq_JUKART_Human1.50070824
55SPI1_23547873_ChIP-Seq_NB4_Human1.47860977
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44955870
57* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43820551
58* SPI1_23127762_ChIP-Seq_K562_Human1.43152486
59ATF3_27146783_Chip-Seq_COLON_Human1.41888982
60* KDM2B_26808549_Chip-Seq_JURKAT_Human1.40541322
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39267006
62* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39106669
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36338215
64MAF_26560356_Chip-Seq_TH2_Human1.35934438
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34878678
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34319013
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33928963
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33433598
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.33323123
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33308876
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.32020024
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29990541
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29858879
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29607799
75* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27790954
76AR_21909140_ChIP-Seq_LNCAP_Human1.27737889
77RACK7_27058665_Chip-Seq_MCF-7_Human1.27714460
78* VDR_24787735_ChIP-Seq_THP-1_Human1.27511335
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26293794
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26242154
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25883504
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25408124
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.24583751
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22987760
85NCOR1_26117541_ChIP-Seq_K562_Human1.20689006
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.19975856
87* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18830329
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17828244
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16256501
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15995087
91* GATA3_26560356_Chip-Seq_TH2_Human1.15332444
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.14915096
93* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14714041
94GATA6_25053715_ChIP-Seq_YYC3_Human1.14636897
95* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14446801
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14318144
97CIITA_25753668_ChIP-Seq_RAJI_Human1.13200662
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12934505
99CHD1_26751641_Chip-Seq_LNCaP_Human1.11794632
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11196302
101* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10761808
102* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10711985
103GATA3_27048872_Chip-Seq_THYMUS_Human1.09440521
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07704999
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.07637552
106KDM5A_27292631_Chip-Seq_BREAST_Human1.06764668
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06543285
108* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06028457
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05900289
110* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05874897
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05844899
112* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05571258
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04727550
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03882871
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03081382
116* TFEB_21752829_ChIP-Seq_HELA_Human1.03046663
117PU_27001747_Chip-Seq_BMDM_Mouse1.02992125
118* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02958664
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02874277
120GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02378617
121SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01498515
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01327169
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01001692
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99932714
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99694781
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98940420
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98624671
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98475303
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.98125497
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97649722
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97198689
132SPI1_20517297_ChIP-Seq_HL60_Human0.96562765
133BCOR_27268052_Chip-Seq_Bcells_Human0.95533763
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94511575
135BCL6_27268052_Chip-Seq_Bcells_Human0.93175338
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92705497
137* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90435366
138* LXR_22292898_ChIP-Seq_THP-1_Human0.88763337
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85935011
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83928001
141RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83449049
142RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80478224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.44471961
2MP0003303_peritoneal_inflammation3.12030136
3MP0010352_gastrointestinal_tract_polyps3.11269985
4MP0008004_abnormal_stomach_pH2.89361806
5MP0003300_gastrointestinal_ulcer2.77113620
6MP0003705_abnormal_hypodermis_morpholog2.64667050
7MP0002396_abnormal_hematopoietic_system2.48242821
8MP0002148_abnormal_hypersensitivity_rea2.43485852
9MP0009278_abnormal_bone_marrow2.38495730
10MP0005076_abnormal_cell_differentiation2.29584431
11MP0010234_abnormal_vibrissa_follicle2.15067070
12MP0004808_abnormal_hematopoietic_stem2.01530946
13MP0005397_hematopoietic_system_phenotyp2.00927513
14MP0001545_abnormal_hematopoietic_system2.00927513
15MP0003693_abnormal_embryo_hatching1.99013451
16MP0003566_abnormal_cell_adhesion1.94300691
17MP0003436_decreased_susceptibility_to1.91959373
18MP0010307_abnormal_tumor_latency1.89624520
19MP0004185_abnormal_adipocyte_glucose1.87880335
20MP0001800_abnormal_humoral_immune1.85074488
21MP0002877_abnormal_melanocyte_morpholog1.85056248
22MP0009333_abnormal_splenocyte_physiolog1.84149468
23MP0000490_abnormal_crypts_of1.80701649
24MP0003763_abnormal_thymus_physiology1.78267799
25MP0002398_abnormal_bone_marrow1.77920026
26MP0000685_abnormal_immune_system1.75377390
27MP0004264_abnormal_extraembryonic_tissu1.71224971
28MP0004947_skin_inflammation1.70640849
29MP0002452_abnormal_antigen_presenting1.68025608
30* MP0004957_abnormal_blastocyst_morpholog1.65773364
31MP0005023_abnormal_wound_healing1.64895971
32MP0003077_abnormal_cell_cycle1.63728204
33MP0003191_abnormal_cellular_cholesterol1.63272791
34MP0003111_abnormal_nucleus_morphology1.60284719
35MP0001790_abnormal_immune_system1.59550083
36MP0005387_immune_system_phenotype1.59550083
37MP0002166_altered_tumor_susceptibility1.57667600
38MP0010155_abnormal_intestine_physiology1.54623002
39MP0009764_decreased_sensitivity_to1.53337563
40MP0000350_abnormal_cell_proliferation1.53034589
41MP0001849_ear_inflammation1.52409449
42MP0001819_abnormal_immune_cell1.51895701
43MP0002420_abnormal_adaptive_immunity1.51859352
44MP0005000_abnormal_immune_tolerance1.50804807
45MP0005671_abnormal_response_to1.49270582
46MP0002405_respiratory_system_inflammati1.47564224
47MP0008260_abnormal_autophagy1.47324177
48MP0008961_abnormal_basal_metabolism1.47175061
49MP0002723_abnormal_immune_serum1.46648966
50MP0003172_abnormal_lysosome_physiology1.46367631
51MP0002722_abnormal_immune_system1.45514145
52MP0000703_abnormal_thymus_morphology1.45389742
53MP0000716_abnormal_immune_system1.44951983
54MP0006054_spinal_hemorrhage1.44813205
55MP0002006_tumorigenesis1.43856281
56MP0003866_abnormal_defecation1.42094606
57MP0001835_abnormal_antigen_presentation1.41298141
58MP0002132_abnormal_respiratory_system1.37739064
59MP0000689_abnormal_spleen_morphology1.37300420
60MP0003448_altered_tumor_morphology1.37149902
61MP0002998_abnormal_bone_remodeling1.36536466
62* MP0001730_embryonic_growth_arrest1.36305839
63MP0000733_abnormal_muscle_development1.34457644
64MP0002429_abnormal_blood_cell1.31689810
65MP0003091_abnormal_cell_migration1.31067055
66MP0005025_abnormal_response_to1.29901628
67MP0010094_abnormal_chromosome_stability1.29521392
68MP0000858_altered_metastatic_potential1.27586869
69MP0001915_intracranial_hemorrhage1.27104658
70* MP0002086_abnormal_extraembryonic_tissu1.25861618
71MP0003075_altered_response_to1.24905254
72MP0000465_gastrointestinal_hemorrhage1.21741625
73MP0001533_abnormal_skeleton_physiology1.21205926
74MP0002019_abnormal_tumor_incidence1.19027072
75MP0004510_myositis1.18366695
76MP0003453_abnormal_keratinocyte_physiol1.18247083
77MP0004381_abnormal_hair_follicle1.17398342
78MP0003984_embryonic_growth_retardation1.16150682
79MP0002419_abnormal_innate_immunity1.13974859
80MP0005464_abnormal_platelet_physiology1.13730196
81MP0002088_abnormal_embryonic_growth/wei1.13448815
82MP0006082_CNS_inflammation1.12549853
83MP0005310_abnormal_salivary_gland1.10874784
84MP0008469_abnormal_protein_level1.10778571
85* MP0001697_abnormal_embryo_size1.10770215
86MP0009763_increased_sensitivity_to1.10533346
87MP0001663_abnormal_digestive_system1.09223567
88MP0009785_altered_susceptibility_to1.09206493
89MP0005380_embryogenesis_phenotype1.08774494
90MP0001672_abnormal_embryogenesis/_devel1.08774494
91MP0005083_abnormal_biliary_tract1.08610137
92MP0003656_abnormal_erythrocyte_physiolo1.08312834
93MP0001873_stomach_inflammation1.06183850
94MP0004130_abnormal_muscle_cell1.05029634
95MP0000249_abnormal_blood_vessel1.05028008
96MP0005451_abnormal_body_composition1.04517165
97MP0004883_abnormal_blood_vessel1.03850404
98* MP0002084_abnormal_developmental_patter1.02336619
99MP0001845_abnormal_inflammatory_respons1.02077697
100MP0001851_eye_inflammation1.01638941
101MP0005058_abnormal_lysosome_morphology1.00606086
102MP0000477_abnormal_intestine_morphology0.99285011
103MP0002925_abnormal_cardiovascular_devel0.99145183
104MP0005166_decreased_susceptibility_to0.98981147
105MP0002653_abnormal_ependyma_morphology0.98896354
106* MP0002080_prenatal_lethality0.97800827
107MP0003045_fibrosis0.97327356
108MP0003183_abnormal_peptide_metabolism0.94851612
109* MP0002085_abnormal_embryonic_tissue0.93312457
110MP0008874_decreased_physiological_sensi0.92661017
111MP0005621_abnormal_cell_physiology0.91826219
112MP0001853_heart_inflammation0.91455637
113MP0000015_abnormal_ear_pigmentation0.88743611
114MP0000313_abnormal_cell_death0.88260405
115MP0009765_abnormal_xenobiotic_induced0.84721824
116MP0005257_abnormal_intraocular_pressure0.83013556
117MP0005164_abnormal_response_to0.82744679
118MP0005390_skeleton_phenotype0.82398032
119MP0008057_abnormal_DNA_replication0.82211862
120MP0002089_abnormal_postnatal_growth/wei0.81903141
121MP0008007_abnormal_cellular_replicative0.81869307
122MP0004197_abnormal_fetal_growth/weight/0.80657640
123MP0009840_abnormal_foam_cell0.78956481
124MP0005167_abnormal_blood-brain_barrier0.78955996
125MP0000537_abnormal_urethra_morphology0.77464377
126MP0003828_pulmonary_edema0.76456393
127MP0000343_altered_response_to0.75179453
128MP0003638_abnormal_response/metabolism_0.73791967
129MP0003279_aneurysm0.72695382
130MP0003795_abnormal_bone_structure0.70949201
131MP0005409_darkened_coat_color0.66963992
132MP0005165_increased_susceptibility_to0.66815475
133MP0000230_abnormal_systemic_arterial0.64739377
134MP0005381_digestive/alimentary_phenotyp0.64472291
135MP0003806_abnormal_nucleotide_metabolis0.63555578
136MP0005535_abnormal_body_temperature0.59732711
137MP0003690_abnormal_glial_cell0.59162846
138MP0004484_altered_response_of0.58286665
139MP0003879_abnormal_hair_cell0.57248597
140MP0004084_abnormal_cardiac_muscle0.56613230
141MP0005666_abnormal_adipose_tissue0.55430126

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.69633909
2Abnormal platelet volume (HP:0011876)6.04609286
3Purpura (HP:0000979)6.01288852
4Menorrhagia (HP:0000132)5.88183580
5Increased mean platelet volume (HP:0011877)5.86240355
6Epistaxis (HP:0000421)5.56394268
7Gingival bleeding (HP:0000225)5.10217857
8Spontaneous hematomas (HP:0007420)4.66977125
9Abnormality of macrophages (HP:0004311)4.33355379
10Stomatitis (HP:0010280)4.12798092
11Abnormal platelet function (HP:0011869)3.84662574
12Impaired platelet aggregation (HP:0003540)3.84662574
13Obstructive lung disease (HP:0006536)3.55417748
14Chronic obstructive pulmonary disease (HP:0006510)3.55417748
15Abnormality of the fingertips (HP:0001211)3.51920659
16Orchitis (HP:0100796)3.42607326
17Autoimmune thrombocytopenia (HP:0001973)3.29093215
18Encephalitis (HP:0002383)3.18218218
19Optic neuritis (HP:0100653)3.10630973
20Retrobulbar optic neuritis (HP:0100654)3.10630973
21Meningitis (HP:0001287)2.98547659
22Recurrent viral infections (HP:0004429)2.91900086
23Chest pain (HP:0100749)2.91719958
24Increased IgM level (HP:0003496)2.84858916
25Gastrointestinal infarctions (HP:0005244)2.83425665
26Vasculitis (HP:0002633)2.83148707
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.81913933
28Increased density of long bones (HP:0006392)2.81726996
29Cellulitis (HP:0100658)2.78074554
30Hyperlipoproteinemia (HP:0010980)2.78027479
31Recurrent gram-negative bacterial infections (HP:0005420)2.77590408
32Recurrent skin infections (HP:0001581)2.70951200
33Arterial thrombosis (HP:0004420)2.67055139
34Autoimmune hemolytic anemia (HP:0001890)2.66675800
35Recurrent fungal infections (HP:0002841)2.65253803
36Eczematoid dermatitis (HP:0000976)2.60268702
37Pustule (HP:0200039)2.52003013
38Gingivitis (HP:0000230)2.50945715
39Bruising susceptibility (HP:0000978)2.50624789
40Chronic otitis media (HP:0000389)2.50535981
41Urticaria (HP:0001025)2.49768514
42Hepatosplenomegaly (HP:0001433)2.49539653
43Hematochezia (HP:0002573)2.48767053
44Recurrent abscess formation (HP:0002722)2.47347874
45Panhypogammaglobulinemia (HP:0003139)2.47061811
46Recurrent cutaneous fungal infections (HP:0011370)2.44310005
47Chronic mucocutaneous candidiasis (HP:0002728)2.44310005
48Episodic fever (HP:0001954)2.43298326
49Joint swelling (HP:0001386)2.40722894
50Genu recurvatum (HP:0002816)2.40031624
51Granulocytopenia (HP:0001913)2.38882267
52Interstitial pulmonary disease (HP:0006530)2.36102777
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.36086120
54Cerebral aneurysm (HP:0004944)2.35168526
55Spondylolisthesis (HP:0003302)2.34856622
56Keratoconjunctivitis sicca (HP:0001097)2.31110917
57Conjunctival telangiectasia (HP:0000524)2.30461702
58Volvulus (HP:0002580)2.28268263
59Abnormality of iron homeostasis (HP:0011031)2.25700933
60Prominent nose (HP:0000448)2.24974298
61Recurrent bacterial skin infections (HP:0005406)2.24731884
62Sparse lateral eyebrow (HP:0005338)2.22626905
63Rectal prolapse (HP:0002035)2.21268301
64Shallow orbits (HP:0000586)2.20512191
65Aortic aneurysm (HP:0004942)2.20178869
66Acute myeloid leukemia (HP:0004808)2.18895516
67Poikilocytosis (HP:0004447)2.18693432
68Abnormality of the heme biosynthetic pathway (HP:0010472)2.18660235
69Dysostosis multiplex (HP:0000943)2.18352055
70Increased serum ferritin (HP:0003281)2.15847104
71Pulmonary infiltrates (HP:0002113)2.15704801
72Long eyelashes (HP:0000527)2.14641775
73Pulmonary embolism (HP:0002204)2.14344735
74Ulnar bowing (HP:0003031)2.14215350
75Verrucae (HP:0200043)2.10654477
76Papilloma (HP:0012740)2.10654477
77Increased IgE level (HP:0003212)2.10172244
78Deviation of the thumb (HP:0009603)2.09698314
79Keratoconjunctivitis (HP:0001096)2.09431031
80Macroorchidism (HP:0000053)2.09092920
81Hypergammaglobulinemia (HP:0010702)2.08296296
82Disinhibition (HP:0000734)2.07751567
83Proximal placement of thumb (HP:0009623)2.07587873
84T lymphocytopenia (HP:0005403)2.06320545
85Pili torti (HP:0003777)2.04456068
86Abnormality of the common coagulation pathway (HP:0010990)2.03869169
87Hemoptysis (HP:0002105)2.01731029
88Vertigo (HP:0002321)2.01371468
89Eosinophilia (HP:0001880)2.00918647
90Blepharitis (HP:0000498)2.00851703
91IgM deficiency (HP:0002850)2.00768576
92Emphysema (HP:0002097)1.98060211
93Microcytic anemia (HP:0001935)1.98046500
94Short 1st metacarpal (HP:0010034)1.97819941
95Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97819941
96Malignant gastrointestinal tract tumors (HP:0006749)1.97579311
97Gastrointestinal carcinoma (HP:0002672)1.97579311
98Polycythemia (HP:0001901)1.97392287
99Osteomyelitis (HP:0002754)1.97234156
100Agammaglobulinemia (HP:0004432)1.96936384
101Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.96364956
102Thrombocytosis (HP:0001894)1.95586487
103Basal cell carcinoma (HP:0002671)1.95363709
104Nasal polyposis (HP:0100582)1.95188680
105Hypochromic microcytic anemia (HP:0004840)1.94389047
106Acanthocytosis (HP:0001927)1.94273929
107Abnormality of T cell physiology (HP:0011840)1.93407223
108Narrow palate (HP:0000189)1.92357167
109Increased cerebral lipofuscin (HP:0011813)1.91558783
110Abnormality of T cell number (HP:0011839)1.90968250
111Mediastinal lymphadenopathy (HP:0100721)1.90435923
112Protrusio acetabuli (HP:0003179)1.87512779
113IgA deficiency (HP:0002720)1.86317610
114Abnormality of the nasal mucosa (HP:0000433)1.85901251
115Gangrene (HP:0100758)1.85371584
116Anorexia (HP:0002039)1.84598277
117Subacute progressive viral hepatitis (HP:0006572)1.84512321
118Glomerulopathy (HP:0100820)1.83515193
119Recurrent bronchitis (HP:0002837)1.82719790
120Gastrointestinal inflammation (HP:0004386)1.82416900
121Myositis (HP:0100614)1.81023438
122Amyloidosis (HP:0011034)1.80928652
123Elevated erythrocyte sedimentation rate (HP:0003565)1.80572924
124Hypochromic anemia (HP:0001931)1.80111758
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79679190
126Lymphopenia (HP:0001888)1.79395993
127Abnormality of transition element cation homeostasis (HP:0011030)1.79245516
128Colitis (HP:0002583)1.79216246
129Arthralgia (HP:0002829)1.79189905
130Amaurosis fugax (HP:0100576)1.77432833
131Hyperacusis (HP:0010780)1.77201003
132Short phalanx of the thumb (HP:0009660)1.76568071
133Inflammation of the large intestine (HP:0002037)1.76547537
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.76463650
135Fatigue (HP:0012378)1.75253136
136Transitional cell carcinoma of the bladder (HP:0006740)1.74700511
137Broad palm (HP:0001169)1.73828190
138Abnormality of the 1st metacarpal (HP:0010009)1.73316859
139Papilledema (HP:0001085)1.69897950
140Aneurysm (HP:0002617)1.69738159
141Increased nuchal translucency (HP:0010880)1.68213279
142Mitral valve prolapse (HP:0001634)1.68210808
143Bladder carcinoma (HP:0002862)1.67987020
144Bladder neoplasm (HP:0009725)1.67987020
145Limited elbow extension (HP:0001377)1.65860542
146Facial hemangioma (HP:0000329)1.64553238
147Somatic mutation (HP:0001428)1.64479190
148Uterine leiomyosarcoma (HP:0002891)1.63879450
149Leiomyosarcoma (HP:0100243)1.63879450
150Combined immunodeficiency (HP:0005387)1.63713963
151Bicuspid aortic valve (HP:0001647)1.63085402
152Abnormality of T cells (HP:0002843)1.63002433
153Urethral obstruction (HP:0000796)1.62218385
154High pitched voice (HP:0001620)1.61230833
155Persistence of primary teeth (HP:0006335)1.60806875
156Broad thumb (HP:0011304)1.60691860
157Abnormality of the peritoneum (HP:0002585)1.59094545
158Skin tags (HP:0010609)1.57474957
159Petechiae (HP:0000967)1.57335833
160Gastrointestinal stroma tumor (HP:0100723)1.57042408
161Leukocytosis (HP:0001974)1.56781862
162Short 4th metacarpal (HP:0010044)1.56773728
163Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.56773728
164Dilatation of the ascending aorta (HP:0005111)1.56316958
165Ependymoma (HP:0002888)1.56011105
166Aortic dissection (HP:0002647)1.55212514
167Thyroiditis (HP:0100646)1.54389312
168Cervical subluxation (HP:0003308)1.53663246
169Annular pancreas (HP:0001734)1.53515414
170Dysmetric saccades (HP:0000641)1.53031911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.47772931
2EEF2K3.31277703
3CDK123.15617259
4TRIB33.09734481
5MAP4K12.89792257
6STK102.76607153
7TAOK12.57262628
8LATS12.33990406
9MAP3K102.33530866
10FES2.31168265
11PKN22.26223762
12ERN12.25024986
13LRRK22.21655726
14PRPF4B2.19724132
15DMPK1.99645084
16IRAK41.93177720
17RPS6KA41.78455755
18TNK21.74786349
19STK31.66903568
20TAOK31.66623695
21SIK31.64233137
22TYK21.59063389
23BMPR21.55486362
24ALK1.53089958
25MAP3K31.45966678
26KSR21.45662802
27JAK31.45290049
28CDC71.44555700
29EPHB11.40837123
30NEK21.39979974
31RIPK11.38692194
32MAP3K141.35687834
33LYN1.35221233
34CDK61.34061158
35MAP3K91.31048239
36GRK61.29451608
37CSK1.26213130
38PAK41.25702076
39PIK3CG1.21104239
40PTK61.19647293
41IKBKB1.18967128
42CAMK1D1.16751847
43ZAP701.16530104
44ITK1.16065439
45KIT1.16037262
46BMX1.12994309
47LATS21.12878989
48PTK2B1.12607006
49TESK21.10377637
50MAP3K81.08491514
51JAK11.08111970
52FGFR31.06142492
53TAOK21.05749934
54PIM21.00606184
55PDK10.99048203
56RPS6KB20.98639388
57MYLK0.97923720
58PIM10.97847837
59TBK10.97702813
60CDK40.96979529
61MAP3K60.95130494
62HIPK20.94411296
63BLK0.93981242
64MAP3K130.93977752
65GRK50.93975394
66MTOR0.90696530
67RAF10.89435793
68IRAK10.88990913
69TYRO30.88612759
70MATK0.87395025
71IRAK30.87355547
72CAMK1G0.87131617
73PDGFRA0.86063186
74BTK0.85767261
75TXK0.80043269
76PDPK10.79887536
77MAPK120.77478326
78CDK70.77172562
79PRKD20.77028334
80FGFR40.75571290
81IRAK20.75228573
82SCYL20.73679877
83MST40.73387457
84YES10.72755158
85HCK0.72120953
86SIK20.69981589
87MARK30.69845607
88CDK90.69321282
89CAMKK20.68788022
90SIK10.68695862
91RET0.68642407
92MAP3K110.68237660
93EIF2AK10.67444736
94PDGFRB0.66810517
95TTK0.65477899
96NLK0.64362534
97PTK20.64346465
98JAK20.63792023
99SYK0.63309646
100LCK0.58341560
101DYRK1B0.56877140
102MAPKAPK30.56195744
103CSF1R0.55428825
104SMG10.55412727
105CDC42BPA0.54793994
106PRKCQ0.54493672
107PAK20.53719412
108TTN0.53650713
109MARK20.52609642
110MAP3K50.52449539
111* FYN0.50867627
112FLT30.50382196
113SGK30.49863316
114MELK0.49646868
115CHUK0.49193879
116CHEK20.48464921
117MAPKAPK20.48204993
118TGFBR20.47590559
119TEC0.46732596
120ILK0.46412649
121CHEK10.45771799
122EGFR0.45684947
123MAP3K20.45258108
124PAK10.45205494
125FGR0.45030511
126CAMKK10.43686162
127MAP2K30.43130638
128CDK20.42807980
129MAP3K10.42590027
130MAPK70.41914241
131MAPK110.41808931
132ICK0.41530932
133DDR20.40909486
134GRK70.39695668
135TGFBR10.39604205
136RPS6KA10.38619791
137SGK20.37272712
138PRKD10.36258405
139MAP3K70.36174061
140IKBKE0.35768469
141RPS6KC10.35362232
142RPS6KL10.35362232
143KDR0.35159723
144EPHA30.35072838
145ARAF0.34694506

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.00829536
2Graft-versus-host disease_Homo sapiens_hsa053321.98918923
3Allograft rejection_Homo sapiens_hsa053301.97206213
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83848709
5Autoimmune thyroid disease_Homo sapiens_hsa053201.82882170
6Chronic myeloid leukemia_Homo sapiens_hsa052201.82112511
7Leishmaniasis_Homo sapiens_hsa051401.77628942
8B cell receptor signaling pathway_Homo sapiens_hsa046621.77013630
9Pancreatic cancer_Homo sapiens_hsa052121.65411464
10Osteoclast differentiation_Homo sapiens_hsa043801.60675749
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59059185
12Acute myeloid leukemia_Homo sapiens_hsa052211.58259995
13Primary immunodeficiency_Homo sapiens_hsa053401.55031949
14mTOR signaling pathway_Homo sapiens_hsa041501.50459563
15Colorectal cancer_Homo sapiens_hsa052101.46203235
16VEGF signaling pathway_Homo sapiens_hsa043701.43332078
17Toxoplasmosis_Homo sapiens_hsa051451.43264188
18Hepatitis B_Homo sapiens_hsa051611.40054820
19Antigen processing and presentation_Homo sapiens_hsa046121.40016506
20Shigellosis_Homo sapiens_hsa051311.39616028
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36956898
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36205981
23Herpes simplex infection_Homo sapiens_hsa051681.35346965
24Adherens junction_Homo sapiens_hsa045201.35277986
25Asthma_Homo sapiens_hsa053101.34473589
26Measles_Homo sapiens_hsa051621.33170201
27Cell cycle_Homo sapiens_hsa041101.30172938
28Renal cell carcinoma_Homo sapiens_hsa052111.29373646
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28268123
30T cell receptor signaling pathway_Homo sapiens_hsa046601.28153212
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.28060013
32Non-small cell lung cancer_Homo sapiens_hsa052231.27612739
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.27357370
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27173545
35MicroRNAs in cancer_Homo sapiens_hsa052061.26364280
36Type I diabetes mellitus_Homo sapiens_hsa049401.24464823
37Phagosome_Homo sapiens_hsa041451.19943883
38* Small cell lung cancer_Homo sapiens_hsa052221.19612478
39Notch signaling pathway_Homo sapiens_hsa043301.18788791
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17636768
41TNF signaling pathway_Homo sapiens_hsa046681.16774518
42Thyroid cancer_Homo sapiens_hsa052161.15149983
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.15123248
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.14826122
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14777802
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11197589
47Hematopoietic cell lineage_Homo sapiens_hsa046401.10957227
48Proteoglycans in cancer_Homo sapiens_hsa052051.10021526
49Influenza A_Homo sapiens_hsa051641.08026418
50Apoptosis_Homo sapiens_hsa042101.07850110
51Endometrial cancer_Homo sapiens_hsa052131.07496096
52Tuberculosis_Homo sapiens_hsa051521.06093725
53HTLV-I infection_Homo sapiens_hsa051661.04157811
54Viral carcinogenesis_Homo sapiens_hsa052031.02503417
55TGF-beta signaling pathway_Homo sapiens_hsa043501.02180810
56Platelet activation_Homo sapiens_hsa046111.02129655
57Prolactin signaling pathway_Homo sapiens_hsa049171.02062175
58Bladder cancer_Homo sapiens_hsa052191.01154133
59Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01121430
60Chemokine signaling pathway_Homo sapiens_hsa040621.00391950
61Glioma_Homo sapiens_hsa052140.99777431
62RNA transport_Homo sapiens_hsa030130.99439476
63HIF-1 signaling pathway_Homo sapiens_hsa040660.98662335
64p53 signaling pathway_Homo sapiens_hsa041150.98626716
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98621466
66Viral myocarditis_Homo sapiens_hsa054160.97686609
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94292592
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.94239591
69Dorso-ventral axis formation_Homo sapiens_hsa043200.92917122
70Rheumatoid arthritis_Homo sapiens_hsa053230.92689044
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92175073
72Prostate cancer_Homo sapiens_hsa052150.91460905
73* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91273266
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88022509
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87114588
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86582865
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85656273
78Focal adhesion_Homo sapiens_hsa045100.85144994
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83614720
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82708860
81African trypanosomiasis_Homo sapiens_hsa051430.82011848
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81432962
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80405111
84Other glycan degradation_Homo sapiens_hsa005110.80337695
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80114165
86Salmonella infection_Homo sapiens_hsa051320.79882527
87Endocytosis_Homo sapiens_hsa041440.79377343
88Renin-angiotensin system_Homo sapiens_hsa046140.77978083
89Hepatitis C_Homo sapiens_hsa051600.77060359
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76839181
91Epstein-Barr virus infection_Homo sapiens_hsa051690.76093912
92FoxO signaling pathway_Homo sapiens_hsa040680.75731647
93Legionellosis_Homo sapiens_hsa051340.75056377
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.74493979
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73918164
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73612310
97Amoebiasis_Homo sapiens_hsa051460.73550651
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.73536528
99mRNA surveillance pathway_Homo sapiens_hsa030150.72352090
100Choline metabolism in cancer_Homo sapiens_hsa052310.71762503
101Hippo signaling pathway_Homo sapiens_hsa043900.71579526
102Base excision repair_Homo sapiens_hsa034100.70171667
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69880332
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69788684
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69538747
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69118558
107Malaria_Homo sapiens_hsa051440.68225465
108Lysosome_Homo sapiens_hsa041420.68098859
109Pertussis_Homo sapiens_hsa051330.67341928
110Estrogen signaling pathway_Homo sapiens_hsa049150.67058154
111RNA degradation_Homo sapiens_hsa030180.66660758
112* Pathways in cancer_Homo sapiens_hsa052000.66378872
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.64791030
114Insulin resistance_Homo sapiens_hsa049310.64672324
115Arachidonic acid metabolism_Homo sapiens_hsa005900.63814547
116Spliceosome_Homo sapiens_hsa030400.63253602
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62843408
118DNA replication_Homo sapiens_hsa030300.62602658
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60782331
120Rap1 signaling pathway_Homo sapiens_hsa040150.59699326
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.59185252
122Mineral absorption_Homo sapiens_hsa049780.57548386
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56631183
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.56466161
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55544790
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55215043
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.53996188
128Gap junction_Homo sapiens_hsa045400.53821480
129Systemic lupus erythematosus_Homo sapiens_hsa053220.51020321
130GnRH signaling pathway_Homo sapiens_hsa049120.48707904
131ErbB signaling pathway_Homo sapiens_hsa040120.46839603
132Inositol phosphate metabolism_Homo sapiens_hsa005620.46078585
133Collecting duct acid secretion_Homo sapiens_hsa049660.41346889

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »