

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 5.02301854 |
| 2 | DNA unwinding involved in DNA replication (GO:0006268) | 4.84127992 |
| 3 | pre-miRNA processing (GO:0031054) | 4.79279987 |
| 4 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 4.67700918 |
| 5 | proline biosynthetic process (GO:0006561) | 4.47993267 |
| 6 | regulation of translational fidelity (GO:0006450) | 4.19912011 |
| 7 | protein localization to kinetochore (GO:0034501) | 4.18978018 |
| 8 | negative regulation of RNA splicing (GO:0033119) | 4.13450197 |
| 9 | heterochromatin organization (GO:0070828) | 4.08685305 |
| 10 | peptidyl-lysine dimethylation (GO:0018027) | 4.06999166 |
| 11 | positive regulation of histone deacetylation (GO:0031065) | 4.05905335 |
| 12 | negative regulation of mRNA processing (GO:0050686) | 3.90844693 |
| 13 | mRNA stabilization (GO:0048255) | 3.89579206 |
| 14 | RNA stabilization (GO:0043489) | 3.89579206 |
| 15 | Golgi transport vesicle coating (GO:0048200) | 3.87486690 |
| 16 | COPI coating of Golgi vesicle (GO:0048205) | 3.87486690 |
| 17 | negative regulation of histone methylation (GO:0031061) | 3.84006115 |
| 18 | ribosomal small subunit biogenesis (GO:0042274) | 3.81100950 |
| 19 | nucleosome disassembly (GO:0006337) | 3.80698430 |
| 20 | protein-DNA complex disassembly (GO:0032986) | 3.80698430 |
| 21 | maternal placenta development (GO:0001893) | 3.76335257 |
| 22 | sister chromatid segregation (GO:0000819) | 3.66960626 |
| 23 | dosage compensation (GO:0007549) | 3.66719494 |
| 24 | negative regulation of mRNA metabolic process (GO:1903312) | 3.65826550 |
| 25 | intracellular estrogen receptor signaling pathway (GO:0030520) | 3.64368548 |
| 26 | glucocorticoid receptor signaling pathway (GO:0042921) | 3.59779433 |
| 27 | protein complex localization (GO:0031503) | 3.54839342 |
| 28 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 3.54361575 |
| 29 | regulation of translational termination (GO:0006449) | 3.53671862 |
| 30 | DNA replication initiation (GO:0006270) | 3.47774361 |
| 31 | mitotic sister chromatid segregation (GO:0000070) | 3.45114741 |
| 32 | negative regulation of cell size (GO:0045792) | 3.44500359 |
| 33 | mitotic G1 DNA damage checkpoint (GO:0031571) | 3.43689987 |
| 34 | protein retention in ER lumen (GO:0006621) | 3.41972720 |
| 35 | protein localization to chromosome, centromeric region (GO:0071459) | 3.41821707 |
| 36 | DNA duplex unwinding (GO:0032508) | 3.41437312 |
| 37 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.41185762 |
| 38 | chromatin assembly (GO:0031497) | 3.40648936 |
| 39 | DNA geometric change (GO:0032392) | 3.36226026 |
| 40 | positive regulation of RNA splicing (GO:0033120) | 3.32375028 |
| 41 | positive regulation of gene expression, epigenetic (GO:0045815) | 3.31606387 |
| 42 | regulation of histone H3-K9 methylation (GO:0051570) | 3.31217067 |
| 43 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.25870640 |
| 44 | cellular protein complex localization (GO:0034629) | 3.25255332 |
| 45 | focal adhesion assembly (GO:0048041) | 3.16797560 |
| 46 | cell-substrate adherens junction assembly (GO:0007045) | 3.16797560 |
| 47 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.15724267 |
| 48 | formation of translation preinitiation complex (GO:0001731) | 3.13427029 |
| 49 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.13379549 |
| 50 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.11786253 |
| 51 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 3.10948278 |
| 52 | regulation of NFAT protein import into nucleus (GO:0051532) | 3.10831448 |
| 53 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 3.09931774 |
| 54 | mitotic chromosome condensation (GO:0007076) | 3.08991137 |
| 55 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.08800747 |
| 56 | positive regulation of protein deacetylation (GO:0090312) | 3.08649872 |
| 57 | regulation of histone H3-K27 methylation (GO:0061085) | 3.07728546 |
| 58 | nuclear pore complex assembly (GO:0051292) | 3.07345538 |
| 59 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling | 3.06407900 |
| 60 | DNA strand elongation (GO:0022616) | 3.06126192 |
| 61 | nuclear pore organization (GO:0006999) | 3.06049115 |
| 62 | regulation of early endosome to late endosome transport (GO:2000641) | 3.04794449 |
| 63 | mitotic nuclear envelope disassembly (GO:0007077) | 3.02332576 |
| 64 | regulation of chromatin binding (GO:0035561) | 2.99762699 |
| 65 | proline metabolic process (GO:0006560) | 2.99345089 |
| 66 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.98070326 |
| 67 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.97334576 |
| 68 | regulation of mRNA stability (GO:0043488) | 2.96904281 |
| 69 | peptidyl-arginine N-methylation (GO:0035246) | 2.94657602 |
| 70 | peptidyl-arginine methylation (GO:0018216) | 2.94657602 |
| 71 | negative regulation of gene expression, epigenetic (GO:0045814) | 2.94357691 |
| 72 | alternative mRNA splicing, via spliceosome (GO:0000380) | 2.92487957 |
| 73 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.92458375 |
| 74 | membrane disassembly (GO:0030397) | 2.92157895 |
| 75 | nuclear envelope disassembly (GO:0051081) | 2.92157895 |
| 76 | histone arginine methylation (GO:0034969) | 2.91716379 |
| 77 | mitotic G1/S transition checkpoint (GO:0044819) | 2.88547328 |
| 78 | activation of Rac GTPase activity (GO:0032863) | 2.87132304 |
| 79 | regulation of sister chromatid cohesion (GO:0007063) | 2.86161811 |
| 80 | chromatin silencing (GO:0006342) | 2.86141000 |
| 81 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.84140498 |
| 82 | G1 DNA damage checkpoint (GO:0044783) | 2.79541777 |
| 83 | glucose catabolic process (GO:0006007) | 2.76339575 |
| 84 | regulation of RNA stability (GO:0043487) | 2.75920899 |
| 85 | regulation of RNA export from nucleus (GO:0046831) | 2.75129487 |
| 86 | protein export from nucleus (GO:0006611) | 2.74841828 |
| 87 | apoptotic process involved in morphogenesis (GO:0060561) | 2.74455804 |
| 88 | gene silencing (GO:0016458) | 2.74043053 |
| 89 | chromosome condensation (GO:0030261) | 2.73808495 |
| 90 | epithelial cell differentiation involved in prostate gland development (GO:0060742) | 2.73536232 |
| 91 | corticosteroid receptor signaling pathway (GO:0031958) | 2.72802633 |
| 92 | establishment of apical/basal cell polarity (GO:0035089) | 2.72264581 |
| 93 | regulation of hippo signaling (GO:0035330) | 2.71945439 |
| 94 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.71071111 |
| 95 | RNA localization (GO:0006403) | 2.69791461 |
| 96 | embryonic eye morphogenesis (GO:0048048) | 2.67751193 |
| 97 | natural killer cell differentiation (GO:0001779) | 2.67575272 |
| 98 | DNA topological change (GO:0006265) | 2.66332517 |
| 99 | histone H4-K16 acetylation (GO:0043984) | 2.66244814 |
| 100 | rRNA transcription (GO:0009303) | 2.65982673 |
| 101 | V(D)J recombination (GO:0033151) | 2.65036717 |
| 102 | embryonic process involved in female pregnancy (GO:0060136) | 2.63514412 |
| 103 | translesion synthesis (GO:0019985) | 2.62514745 |
| 104 | trophectodermal cell differentiation (GO:0001829) | 2.62301547 |
| 105 | snRNA metabolic process (GO:0016073) | 2.62192015 |
| 106 | apoptotic process involved in development (GO:1902742) | 2.62142023 |
| 107 | adherens junction assembly (GO:0034333) | 2.62123049 |
| 108 | NLS-bearing protein import into nucleus (GO:0006607) | 2.62005815 |
| 109 | mannose metabolic process (GO:0006013) | 2.61580903 |
| 110 | viral transcription (GO:0019083) | 2.60827232 |
| 111 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.60544891 |
| 112 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.60544891 |
| 113 | histone H4-K12 acetylation (GO:0043983) | 2.60332101 |
| 114 | regulation of gene silencing by miRNA (GO:0060964) | 2.59892373 |
| 115 | regulation of gene silencing by RNA (GO:0060966) | 2.59892373 |
| 116 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.59892373 |
| 117 | modulation by virus of host process (GO:0019054) | 2.59770530 |
| 118 | mitotic sister chromatid cohesion (GO:0007064) | 2.59474485 |
| 119 | DNA conformation change (GO:0071103) | 2.59350275 |
| 120 | response to epidermal growth factor (GO:0070849) | 2.59002293 |
| 121 | glucose 6-phosphate metabolic process (GO:0051156) | 2.58916684 |
| 122 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.58747975 |
| 123 | positive regulation of chromosome segregation (GO:0051984) | 2.58006039 |
| 124 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.57558713 |
| 125 | negative regulation of histone modification (GO:0031057) | 2.56988294 |
| 126 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.56950299 |
| 127 | IMP biosynthetic process (GO:0006188) | 2.56710314 |
| 128 | histone H3-K36 demethylation (GO:0070544) | 2.56552019 |
| 129 | negative regulation of histone acetylation (GO:0035067) | 2.55384998 |
| 130 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.55245228 |
| 131 | positive thymic T cell selection (GO:0045059) | 2.55158412 |
| 132 | regulation of DNA damage checkpoint (GO:2000001) | 2.55062267 |
| 133 | regulation of gamma-delta T cell activation (GO:0046643) | 2.54916046 |
| 134 | histone H4-K5 acetylation (GO:0043981) | 2.54637779 |
| 135 | histone H4-K8 acetylation (GO:0043982) | 2.54637779 |
| 136 | nuclear envelope organization (GO:0006998) | 2.53325654 |
| 137 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.53120627 |
| 138 | NADPH regeneration (GO:0006740) | 2.52722613 |
| 139 | cellular response to epidermal growth factor stimulus (GO:0071364) | 2.52545171 |
| 140 | regulation of fatty acid beta-oxidation (GO:0031998) | 2.52067026 |
| 141 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.50456091 |
| 142 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.50066947 |
| 143 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.49367450 |
| 144 | pentose-phosphate shunt (GO:0006098) | 2.49260042 |
| 145 | cellular hyperosmotic response (GO:0071474) | 2.48246805 |
| 146 | lymph vessel development (GO:0001945) | 2.48139605 |
| 147 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.48046669 |
| 148 | negative regulation of fatty acid transport (GO:2000192) | 2.45621343 |
| 149 | histone H2A monoubiquitination (GO:0035518) | 2.45331190 |
| 150 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling | 2.45315610 |
| 151 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | 2.45315610 |
| 152 | positive regulation of nuclease activity (GO:0032075) | 2.44321045 |
| 153 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 2.43283098 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.44064508 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.47715085 |
| 3 | * MYC_22102868_ChIP-Seq_BL_Human | 4.20711107 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.40310259 |
| 5 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.90191869 |
| 6 | * VDR_21846776_ChIP-Seq_THP-1_Human | 2.88071313 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.79179794 |
| 8 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 2.50134539 |
| 9 | * KDM2B_26808549_Chip-Seq_DND41_Human | 2.48042895 |
| 10 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.42806557 |
| 11 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.26124353 |
| 12 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.26088376 |
| 13 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.21852425 |
| 14 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.04473783 |
| 15 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.03783349 |
| 16 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.03594598 |
| 17 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.99999761 |
| 18 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.96258944 |
| 19 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.93393374 |
| 20 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.92140125 |
| 21 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.90912045 |
| 22 | UTX_26944678_Chip-Seq_JUKART_Human | 1.84832443 |
| 23 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.83462874 |
| 24 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.81694045 |
| 25 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.77828432 |
| 26 | * MAF_26560356_Chip-Seq_TH1_Human | 1.76977447 |
| 27 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.71576221 |
| 28 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.70557671 |
| 29 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.66128123 |
| 30 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.65634183 |
| 31 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.65139007 |
| 32 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.62677391 |
| 33 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.62231028 |
| 34 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.55822893 |
| 35 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.53553222 |
| 36 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.51333353 |
| 37 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.50555469 |
| 38 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.45841702 |
| 39 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.45204965 |
| 40 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.44400349 |
| 41 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.42587664 |
| 42 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.42389210 |
| 43 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 1.42306168 |
| 44 | * VDR_24763502_ChIP-Seq_THP-1_Human | 1.40400090 |
| 45 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.37931210 |
| 46 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.36972218 |
| 47 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.36374143 |
| 48 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.35622939 |
| 49 | * NCOR1_26117541_ChIP-Seq_K562_Human | 1.35413318 |
| 50 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.34873104 |
| 51 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.32734071 |
| 52 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.32192078 |
| 53 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.31352121 |
| 54 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.31147655 |
| 55 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.29417885 |
| 56 | * MAF_26560356_Chip-Seq_TH2_Human | 1.28224268 |
| 57 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.28218468 |
| 58 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.27381033 |
| 59 | * P68_20966046_ChIP-Seq_HELA_Human | 1.26459202 |
| 60 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.25928812 |
| 61 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.23577050 |
| 62 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.22586684 |
| 63 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.22498233 |
| 64 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.21896314 |
| 65 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.21589796 |
| 66 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.21329641 |
| 67 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.20130977 |
| 68 | * CREB1_26743006_Chip-Seq_LNCaP_Human | 1.19860973 |
| 69 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19453158 |
| 70 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.18721810 |
| 71 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.17237345 |
| 72 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.16382004 |
| 73 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.16353305 |
| 74 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.15348730 |
| 75 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.14884781 |
| 76 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.14254862 |
| 77 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.13084322 |
| 78 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.12880153 |
| 79 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.12328999 |
| 80 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.11213977 |
| 81 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.10494056 |
| 82 | ATF3_27146783_Chip-Seq_COLON_Human | 1.10438660 |
| 83 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.10044859 |
| 84 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.09995942 |
| 85 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.09657966 |
| 86 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.09649473 |
| 87 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.08457911 |
| 88 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.07929862 |
| 89 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.07738410 |
| 90 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.07207551 |
| 91 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.06892330 |
| 92 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.06621572 |
| 93 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.06569762 |
| 94 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.06140297 |
| 95 | * MYB_26560356_Chip-Seq_TH1_Human | 1.05827671 |
| 96 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.05771566 |
| 97 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.05433042 |
| 98 | * CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.05006392 |
| 99 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.04845738 |
| 100 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.04516429 |
| 101 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.03622415 |
| 102 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.03059010 |
| 103 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.02634082 |
| 104 | * MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.02467691 |
| 105 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.01868425 |
| 106 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.01327045 |
| 107 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.01072720 |
| 108 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 1.00683469 |
| 109 | * MYB_26560356_Chip-Seq_TH2_Human | 1.00550137 |
| 110 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.99728877 |
| 111 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.99479410 |
| 112 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.99139380 |
| 113 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.98623557 |
| 114 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.98083397 |
| 115 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.97976911 |
| 116 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.97922208 |
| 117 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.97528995 |
| 118 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.97495060 |
| 119 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.96306287 |
| 120 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.95824249 |
| 121 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.94662227 |
| 122 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.94049899 |
| 123 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.92873164 |
| 124 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.92826556 |
| 125 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.92387798 |
| 126 | * TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.92228256 |
| 127 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.91984885 |
| 128 | SPI1_23127762_ChIP-Seq_K562_Human | 0.91225022 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003705_abnormal_hypodermis_morpholog | 3.88743342 |
| 2 | MP0005076_abnormal_cell_differentiation | 3.23434631 |
| 3 | MP0009278_abnormal_bone_marrow | 3.09039560 |
| 4 | MP0010352_gastrointestinal_tract_polyps | 2.97431301 |
| 5 | MP0002249_abnormal_larynx_morphology | 2.85112277 |
| 6 | MP0003111_abnormal_nucleus_morphology | 2.82701911 |
| 7 | MP0005451_abnormal_body_composition | 2.76105401 |
| 8 | MP0010094_abnormal_chromosome_stability | 2.45719287 |
| 9 | MP0000678_abnormal_parathyroid_gland | 2.29091431 |
| 10 | MP0001849_ear_inflammation | 2.29075105 |
| 11 | MP0002396_abnormal_hematopoietic_system | 2.26351106 |
| 12 | MP0003077_abnormal_cell_cycle | 2.23408222 |
| 13 | MP0001730_embryonic_growth_arrest | 2.13512981 |
| 14 | MP0004957_abnormal_blastocyst_morpholog | 2.13012505 |
| 15 | MP0008961_abnormal_basal_metabolism | 2.11728605 |
| 16 | MP0010307_abnormal_tumor_latency | 2.10728114 |
| 17 | MP0003300_gastrointestinal_ulcer | 2.09212227 |
| 18 | MP0004197_abnormal_fetal_growth/weight/ | 2.04315869 |
| 19 | MP0003123_paternal_imprinting | 2.04049364 |
| 20 | MP0004808_abnormal_hematopoietic_stem | 2.02972769 |
| 21 | MP0003303_peritoneal_inflammation | 2.01694488 |
| 22 | MP0001346_abnormal_lacrimal_gland | 1.91920441 |
| 23 | MP0000350_abnormal_cell_proliferation | 1.91000030 |
| 24 | MP0005409_darkened_coat_color | 1.86940558 |
| 25 | MP0005058_abnormal_lysosome_morphology | 1.86847027 |
| 26 | MP0002009_preneoplasia | 1.84518860 |
| 27 | MP0002653_abnormal_ependyma_morphology | 1.83064547 |
| 28 | MP0003283_abnormal_digestive_organ | 1.80106583 |
| 29 | MP0005397_hematopoietic_system_phenotyp | 1.79955037 |
| 30 | MP0001545_abnormal_hematopoietic_system | 1.79955037 |
| 31 | MP0000566_synostosis | 1.77087691 |
| 32 | MP0000703_abnormal_thymus_morphology | 1.76426376 |
| 33 | MP0002084_abnormal_developmental_patter | 1.74702951 |
| 34 | MP0003693_abnormal_embryo_hatching | 1.73019357 |
| 35 | MP0005380_embryogenesis_phenotype | 1.68780353 |
| 36 | MP0001672_abnormal_embryogenesis/_devel | 1.68780353 |
| 37 | MP0002086_abnormal_extraembryonic_tissu | 1.68351695 |
| 38 | MP0000537_abnormal_urethra_morphology | 1.65297729 |
| 39 | MP0001697_abnormal_embryo_size | 1.64519649 |
| 40 | MP0003984_embryonic_growth_retardation | 1.62710781 |
| 41 | MP0008057_abnormal_DNA_replication | 1.62271817 |
| 42 | MP0002085_abnormal_embryonic_tissue | 1.61344731 |
| 43 | MP0002088_abnormal_embryonic_growth/wei | 1.61036428 |
| 44 | MP0003315_abnormal_perineum_morphology | 1.57146022 |
| 45 | MP0002080_prenatal_lethality | 1.55306881 |
| 46 | MP0003119_abnormal_digestive_system | 1.53211843 |
| 47 | MP0005666_abnormal_adipose_tissue | 1.49674379 |
| 48 | MP0009672_abnormal_birth_weight | 1.46896211 |
| 49 | MP0000733_abnormal_muscle_development | 1.45390588 |
| 50 | MP0002796_impaired_skin_barrier | 1.44663821 |
| 51 | MP0004381_abnormal_hair_follicle | 1.42403268 |
| 52 | MP0003763_abnormal_thymus_physiology | 1.41272516 |
| 53 | MP0008260_abnormal_autophagy | 1.41242317 |
| 54 | MP0003566_abnormal_cell_adhesion | 1.39325120 |
| 55 | MP0002398_abnormal_bone_marrow | 1.38946735 |
| 56 | MP0004233_abnormal_muscle_weight | 1.37785753 |
| 57 | MP0010234_abnormal_vibrissa_follicle | 1.36052081 |
| 58 | MP0006054_spinal_hemorrhage | 1.35972812 |
| 59 | MP0005501_abnormal_skin_physiology | 1.35236125 |
| 60 | MP0004858_abnormal_nervous_system | 1.33271101 |
| 61 | MP0010030_abnormal_orbit_morphology | 1.32638312 |
| 62 | MP0003121_genomic_imprinting | 1.30594783 |
| 63 | MP0008770_decreased_survivor_rate | 1.29250662 |
| 64 | MP0003115_abnormal_respiratory_system | 1.27903524 |
| 65 | MP0000685_abnormal_immune_system | 1.26748529 |
| 66 | MP0000490_abnormal_crypts_of | 1.26640574 |
| 67 | MP0009053_abnormal_anal_canal | 1.25497570 |
| 68 | MP0008007_abnormal_cellular_replicative | 1.24370266 |
| 69 | MP0003567_abnormal_fetal_cardiomyocyte | 1.24190089 |
| 70 | MP0002722_abnormal_immune_system | 1.23045343 |
| 71 | MP0000428_abnormal_craniofacial_morphol | 1.21696684 |
| 72 | MP0000681_abnormal_thyroid_gland | 1.21160098 |
| 73 | MP0009703_decreased_birth_body | 1.18770365 |
| 74 | MP0005375_adipose_tissue_phenotype | 1.17423045 |
| 75 | MP0002019_abnormal_tumor_incidence | 1.16760521 |
| 76 | MP0003453_abnormal_keratinocyte_physiol | 1.16263468 |
| 77 | MP0001915_intracranial_hemorrhage | 1.14936072 |
| 78 | MP0002877_abnormal_melanocyte_morpholog | 1.14429604 |
| 79 | MP0002089_abnormal_postnatal_growth/wei | 1.13568794 |
| 80 | MP0002925_abnormal_cardiovascular_devel | 1.13386234 |
| 81 | MP0000313_abnormal_cell_death | 1.12998619 |
| 82 | MP0002098_abnormal_vibrissa_morphology | 1.10995030 |
| 83 | MP0000689_abnormal_spleen_morphology | 1.06330634 |
| 84 | MP0004185_abnormal_adipocyte_glucose | 1.06104440 |
| 85 | MP0010630_abnormal_cardiac_muscle | 0.98705287 |
| 86 | MP0003890_abnormal_embryonic-extraembry | 0.97720577 |
| 87 | MP0002092_abnormal_eye_morphology | 0.96983699 |
| 88 | MP0005623_abnormal_meninges_morphology | 0.92846888 |
| 89 | MP0003935_abnormal_craniofacial_develop | 0.92830144 |
| 90 | MP0000462_abnormal_digestive_system | 0.92721938 |
| 91 | MP0000266_abnormal_heart_morphology | 0.92480767 |
| 92 | MP0000747_muscle_weakness | 0.90528555 |
| 93 | MP0003122_maternal_imprinting | 0.88886936 |
| 94 | MP0009333_abnormal_splenocyte_physiolog | 0.88549185 |
| 95 | MP0002429_abnormal_blood_cell | 0.88324637 |
| 96 | MP0001661_extended_life_span | 0.88293339 |
| 97 | MP0000858_altered_metastatic_potential | 0.88251806 |
| 98 | MP0001348_abnormal_lacrimal_gland | 0.87838693 |
| 99 | MP0003861_abnormal_nervous_system | 0.87763404 |
| 100 | MP0003787_abnormal_imprinting | 0.87131188 |
| 101 | MP0001293_anophthalmia | 0.86466563 |
| 102 | MP0005023_abnormal_wound_healing | 0.86012565 |
| 103 | MP0009931_abnormal_skin_appearance | 0.81272296 |
| 104 | MP0000477_abnormal_intestine_morphology | 0.81192265 |
| 105 | MP0000716_abnormal_immune_system | 0.80877728 |
| 106 | MP0002114_abnormal_axial_skeleton | 0.80791320 |
| 107 | MP0002932_abnormal_joint_morphology | 0.80495942 |
| 108 | MP0001784_abnormal_fluid_regulation | 0.79017802 |
| 109 | MP0000759_abnormal_skeletal_muscle | 0.78436176 |
| 110 | MP0009379_abnormal_foot_pigmentation | 0.77837386 |
| 111 | MP0002970_abnormal_white_adipose | 0.77768003 |
| 112 | MP0000003_abnormal_adipose_tissue | 0.77644624 |
| 113 | MP0004782_abnormal_surfactant_physiolog | 0.76933018 |
| 114 | MP0002697_abnormal_eye_size | 0.76380138 |
| 115 | MP0008438_abnormal_cutaneous_collagen | 0.75938902 |
| 116 | MP0000534_abnormal_ureter_morphology | 0.75642188 |
| 117 | MP0003866_abnormal_defecation | 0.75225065 |
| 118 | MP0002116_abnormal_craniofacial_bone | 0.75085721 |
| 119 | MP0002111_abnormal_tail_morphology | 0.74684326 |
| 120 | MP0009840_abnormal_foam_cell | 0.73720242 |
| 121 | MP0000467_abnormal_esophagus_morphology | 0.73642884 |
| 122 | MP0003172_abnormal_lysosome_physiology | 0.73521899 |
| 123 | MP0005384_cellular_phenotype | 0.72937369 |
| 124 | MP0002060_abnormal_skin_morphology | 0.71915036 |
| 125 | MP0003656_abnormal_erythrocyte_physiolo | 0.70005909 |
| 126 | MP0003942_abnormal_urinary_system | 0.69513647 |
| 127 | MP0004087_abnormal_muscle_fiber | 0.67405287 |
| 128 | MP0004947_skin_inflammation | 0.67313724 |
| 129 | MP0005187_abnormal_penis_morphology | 0.66776692 |
| 130 | MP0008932_abnormal_embryonic_tissue | 0.66277723 |
| 131 | MP0005621_abnormal_cell_physiology | 0.66150906 |
| 132 | MP0004264_abnormal_extraembryonic_tissu | 0.64803466 |
| 133 | MP0003385_abnormal_body_wall | 0.64253114 |
| 134 | MP0002166_altered_tumor_susceptibility | 0.64099430 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hyperacusis (HP:0010780) | 4.82275958 |
| 2 | Insomnia (HP:0100785) | 3.63270267 |
| 3 | Renal duplication (HP:0000075) | 3.61979458 |
| 4 | Elfin facies (HP:0004428) | 3.46316495 |
| 5 | Renovascular hypertension (HP:0100817) | 3.32367587 |
| 6 | Asymmetry of the thorax (HP:0001555) | 3.30368314 |
| 7 | Short 4th metacarpal (HP:0010044) | 3.23955216 |
| 8 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 3.23955216 |
| 9 | Overriding aorta (HP:0002623) | 3.09014041 |
| 10 | Increased nuchal translucency (HP:0010880) | 3.07117374 |
| 11 | Abnormality of the lower motor neuron (HP:0002366) | 3.01683790 |
| 12 | Ependymoma (HP:0002888) | 3.00921151 |
| 13 | Septate vagina (HP:0001153) | 2.89216188 |
| 14 | Broad distal phalanx of finger (HP:0009836) | 2.88262021 |
| 15 | Cerebral aneurysm (HP:0004944) | 2.73289609 |
| 16 | Pointed chin (HP:0000307) | 2.71639850 |
| 17 | Bowel diverticulosis (HP:0005222) | 2.60915299 |
| 18 | Abnormality of the 4th metacarpal (HP:0010012) | 2.58734715 |
| 19 | Astrocytoma (HP:0009592) | 2.57348208 |
| 20 | Abnormality of the astrocytes (HP:0100707) | 2.57348208 |
| 21 | Broad face (HP:0000283) | 2.56889200 |
| 22 | Long palpebral fissure (HP:0000637) | 2.56807791 |
| 23 | Macroorchidism (HP:0000053) | 2.53700293 |
| 24 | Broad palm (HP:0001169) | 2.49628388 |
| 25 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 2.48723937 |
| 26 | Abnormality of the fingertips (HP:0001211) | 2.47920734 |
| 27 | Pseudobulbar signs (HP:0002200) | 2.47555433 |
| 28 | Flat cornea (HP:0007720) | 2.45493823 |
| 29 | Truncus arteriosus (HP:0001660) | 2.45143904 |
| 30 | Basal cell carcinoma (HP:0002671) | 2.44993811 |
| 31 | Germ cell neoplasia (HP:0100728) | 2.44162586 |
| 32 | Shallow orbits (HP:0000586) | 2.44142089 |
| 33 | Obstructive sleep apnea (HP:0002870) | 2.41518555 |
| 34 | Ulnar bowing (HP:0003031) | 2.35378542 |
| 35 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.35016694 |
| 36 | Flat acetabular roof (HP:0003180) | 2.34569244 |
| 37 | Abnormality of the thoracic spine (HP:0100711) | 2.31779478 |
| 38 | Annular pancreas (HP:0001734) | 2.25841422 |
| 39 | Bladder diverticulum (HP:0000015) | 2.23029174 |
| 40 | Self-mutilation (HP:0000742) | 2.22055087 |
| 41 | Sparse lateral eyebrow (HP:0005338) | 2.21897025 |
| 42 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.20344637 |
| 43 | Heterotopia (HP:0002282) | 2.19278213 |
| 44 | Papilloma (HP:0012740) | 2.19262386 |
| 45 | Verrucae (HP:0200043) | 2.19262386 |
| 46 | Hand muscle atrophy (HP:0009130) | 2.18489370 |
| 47 | Progressive muscle weakness (HP:0003323) | 2.18168539 |
| 48 | Abnormality of the columella (HP:0009929) | 2.15420867 |
| 49 | Abnormality of the diencephalon (HP:0010662) | 2.14646418 |
| 50 | Patellar dislocation (HP:0002999) | 2.13840416 |
| 51 | Abnormal gallbladder physiology (HP:0012438) | 2.13649843 |
| 52 | Cholecystitis (HP:0001082) | 2.13649843 |
| 53 | High anterior hairline (HP:0009890) | 2.10404560 |
| 54 | Increased density of long bones (HP:0006392) | 2.09143571 |
| 55 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.07998426 |
| 56 | Enlarged penis (HP:0000040) | 2.07795316 |
| 57 | Hyperthyroidism (HP:0000836) | 2.07720091 |
| 58 | Bowel incontinence (HP:0002607) | 2.06126103 |
| 59 | Hallux valgus (HP:0001822) | 2.05160118 |
| 60 | Distal upper limb amyotrophy (HP:0007149) | 2.04586651 |
| 61 | Upper limb amyotrophy (HP:0009129) | 2.04586651 |
| 62 | Megalocornea (HP:0000485) | 2.04210342 |
| 63 | Abnormality of the Achilles tendon (HP:0005109) | 2.04209752 |
| 64 | Selective tooth agenesis (HP:0001592) | 2.03225137 |
| 65 | High pitched voice (HP:0001620) | 1.99509671 |
| 66 | Ankyloglossia (HP:0010296) | 1.98838805 |
| 67 | Deviation of the hallux (HP:0010051) | 1.98616258 |
| 68 | Sacral dimple (HP:0000960) | 1.98138301 |
| 69 | Trismus (HP:0000211) | 1.97571757 |
| 70 | Myopathic facies (HP:0002058) | 1.97273649 |
| 71 | Neoplasm of the heart (HP:0100544) | 1.97162576 |
| 72 | Biconcave vertebral bodies (HP:0004586) | 1.96914884 |
| 73 | Abnormal large intestine physiology (HP:0012700) | 1.96471434 |
| 74 | Fibroma (HP:0010614) | 1.96440633 |
| 75 | Subacute progressive viral hepatitis (HP:0006572) | 1.95003911 |
| 76 | Abnormality of the aortic arch (HP:0012303) | 1.94822157 |
| 77 | Skin tags (HP:0010609) | 1.94058863 |
| 78 | Hyperparathyroidism (HP:0000843) | 1.93515515 |
| 79 | Lymphangioma (HP:0100764) | 1.92695870 |
| 80 | Fibrous tissue neoplasm (HP:0012316) | 1.92530431 |
| 81 | Obsessive-compulsive behavior (HP:0000722) | 1.92369378 |
| 82 | Angiofibromas (HP:0010615) | 1.91893051 |
| 83 | Adenoma sebaceum (HP:0009720) | 1.91893051 |
| 84 | Turricephaly (HP:0000262) | 1.89887302 |
| 85 | Thoracic kyphosis (HP:0002942) | 1.89614916 |
| 86 | Premature skin wrinkling (HP:0100678) | 1.89125727 |
| 87 | Medulloblastoma (HP:0002885) | 1.88749635 |
| 88 | Neoplasm of striated muscle (HP:0009728) | 1.88575592 |
| 89 | Abnormality of oral frenula (HP:0000190) | 1.87392737 |
| 90 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.87378124 |
| 91 | Genu recurvatum (HP:0002816) | 1.86836466 |
| 92 | Vertebral arch anomaly (HP:0008438) | 1.86780066 |
| 93 | Thin ribs (HP:0000883) | 1.86695699 |
| 94 | Abnormal ventriculo-arterial connection (HP:0011563) | 1.86466975 |
| 95 | Transposition of the great arteries (HP:0001669) | 1.86466975 |
| 96 | Abnormal connection of the cardiac segments (HP:0011545) | 1.86466975 |
| 97 | Vertebral compression fractures (HP:0002953) | 1.84947192 |
| 98 | Stridor (HP:0010307) | 1.84785955 |
| 99 | Cellulitis (HP:0100658) | 1.84304902 |
| 100 | Long eyelashes (HP:0000527) | 1.84296518 |
| 101 | Mitral valve prolapse (HP:0001634) | 1.83619155 |
| 102 | Abnormality of reticulocytes (HP:0004312) | 1.83526029 |
| 103 | Rectal prolapse (HP:0002035) | 1.83372629 |
| 104 | Proximal placement of thumb (HP:0009623) | 1.81866531 |
| 105 | Deviation of the thumb (HP:0009603) | 1.80981654 |
| 106 | Distal lower limb amyotrophy (HP:0008944) | 1.80505691 |
| 107 | Syringomyelia (HP:0003396) | 1.80357331 |
| 108 | Spinal cord lesions (HP:0100561) | 1.80357331 |
| 109 | Broad thumb (HP:0011304) | 1.79791299 |
| 110 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.79260975 |
| 111 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.79260975 |
| 112 | Single umbilical artery (HP:0001195) | 1.79260975 |
| 113 | Reticulocytosis (HP:0001923) | 1.78920294 |
| 114 | Abnormality of the umbilical cord (HP:0010881) | 1.78829012 |
| 115 | Protrusio acetabuli (HP:0003179) | 1.78407679 |
| 116 | Spina bifida occulta (HP:0003298) | 1.76904067 |
| 117 | Dysmetric saccades (HP:0000641) | 1.76771648 |
| 118 | Trigonocephaly (HP:0000243) | 1.75994237 |
| 119 | Gastrointestinal carcinoma (HP:0002672) | 1.73949584 |
| 120 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.73949584 |
| 121 | Glioma (HP:0009733) | 1.72177329 |
| 122 | Urethral obstruction (HP:0000796) | 1.72131451 |
| 123 | Hemorrhage of the eye (HP:0011885) | 1.72042689 |
| 124 | Bicuspid aortic valve (HP:0001647) | 1.71324898 |
| 125 | Hypoparathyroidism (HP:0000829) | 1.70182075 |
| 126 | Anal stenosis (HP:0002025) | 1.70037369 |
| 127 | Neoplasm of the oral cavity (HP:0100649) | 1.69383744 |
| 128 | Cutis marmorata (HP:0000965) | 1.68589168 |
| 129 | Deep venous thrombosis (HP:0002625) | 1.67988631 |
| 130 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.67472023 |
| 131 | Amyotrophic lateral sclerosis (HP:0007354) | 1.66943667 |
| 132 | Overlapping toe (HP:0001845) | 1.66169368 |
| 133 | Dislocated radial head (HP:0003083) | 1.66150843 |
| 134 | Disproportionate tall stature (HP:0001519) | 1.65585593 |
| 135 | Intestinal fistula (HP:0100819) | 1.65447344 |
| 136 | Precocious puberty (HP:0000826) | 1.64961132 |
| 137 | Volvulus (HP:0002580) | 1.64787859 |
| 138 | Achilles tendon contracture (HP:0001771) | 1.64617905 |
| 139 | Cutaneous melanoma (HP:0012056) | 1.64455274 |
| 140 | Spinal cord compression (HP:0002176) | 1.64127365 |
| 141 | Acute lymphatic leukemia (HP:0006721) | 1.64058603 |
| 142 | Ragged-red muscle fibers (HP:0003200) | 1.63731771 |
| 143 | Seborrheic dermatitis (HP:0001051) | 1.62324235 |
| 144 | Atresia of the external auditory canal (HP:0000413) | 1.62126392 |
| 145 | Spastic diplegia (HP:0001264) | 1.62096912 |
| 146 | Cafe-au-lait spot (HP:0000957) | 1.61662445 |
| 147 | Short 5th finger (HP:0009237) | 1.61624098 |
| 148 | Panhypogammaglobulinemia (HP:0003139) | 1.61356649 |
| 149 | Abnormality of the radial head (HP:0003995) | 1.61165173 |
| 150 | Metaphyseal cupping (HP:0003021) | 1.61064806 |
| 151 | Abnormality of the calcaneus (HP:0008364) | 1.59882725 |
| 152 | Missing ribs (HP:0000921) | 1.59853232 |
| 153 | Preauricular skin tag (HP:0000384) | 1.59852180 |
| 154 | Intestinal polyp (HP:0005266) | 1.59666103 |
| 155 | Thin bony cortex (HP:0002753) | 1.59504590 |
| 156 | Supernumerary ribs (HP:0005815) | 1.59123634 |
| 157 | Short phalanx of the thumb (HP:0009660) | 1.58969275 |
| 158 | Hypercortisolism (HP:0001578) | 1.57159944 |
| 159 | Back pain (HP:0003418) | 1.57002511 |
| 160 | Arnold-Chiari malformation (HP:0002308) | 1.56846397 |
| 161 | Recurrent viral infections (HP:0004429) | 1.54760914 |
| 162 | Colon cancer (HP:0003003) | 1.54498550 |
| 163 | Abnormal number of incisors (HP:0011064) | 1.53153670 |
| 164 | T lymphocytopenia (HP:0005403) | 1.52900708 |
| 165 | Deep palmar crease (HP:0006191) | 1.52894389 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EEF2K | 4.84387718 |
| 2 | TRIB3 | 4.57280593 |
| 3 | MAP3K10 | 4.52124965 |
| 4 | SMG1 | 4.15745266 |
| 5 | PKN2 | 4.10703261 |
| 6 | CDK12 | 3.24013137 |
| 7 | PRPF4B | 3.20061535 |
| 8 | IRAK3 | 2.65661449 |
| 9 | ICK | 2.36032154 |
| 10 | NME2 | 2.17197648 |
| 11 | CDC7 | 2.15102817 |
| 12 | NEK2 | 2.08379891 |
| 13 | MAP4K1 | 1.90356082 |
| 14 | ALK | 1.82488796 |
| 15 | ERN1 | 1.77740002 |
| 16 | SIK2 | 1.74366537 |
| 17 | PTK6 | 1.73348557 |
| 18 | GRK6 | 1.64869240 |
| 19 | PDGFRA | 1.53378394 |
| 20 | RIPK1 | 1.52031006 |
| 21 | TYRO3 | 1.48836291 |
| 22 | SCYL2 | 1.45277478 |
| 23 | RPS6KB2 | 1.41467306 |
| 24 | CDK4 | 1.34317829 |
| 25 | LRRK2 | 1.33483105 |
| 26 | TAOK1 | 1.25581742 |
| 27 | BMX | 1.24237068 |
| 28 | STK10 | 1.23751178 |
| 29 | NEK1 | 1.23210952 |
| 30 | MTOR | 1.22994514 |
| 31 | SIK1 | 1.20364572 |
| 32 | PASK | 1.19683483 |
| 33 | CDK6 | 1.16522080 |
| 34 | TTN | 1.15654906 |
| 35 | PAK4 | 1.14283981 |
| 36 | IRAK2 | 1.13094954 |
| 37 | PRKD3 | 1.10328951 |
| 38 | TAOK2 | 1.05050452 |
| 39 | BRAF | 0.95577055 |
| 40 | ARAF | 0.95413260 |
| 41 | MAP2K2 | 0.93832970 |
| 42 | MAP3K8 | 0.91642561 |
| 43 | TESK2 | 0.90550700 |
| 44 | MAP3K7 | 0.89138184 |
| 45 | BRD4 | 0.88496897 |
| 46 | FLT3 | 0.87956039 |
| 47 | PDPK1 | 0.85804597 |
| 48 | EPHA2 | 0.83908437 |
| 49 | MAP3K13 | 0.83854575 |
| 50 | CDK7 | 0.80430795 |
| 51 | MAP3K1 | 0.78162857 |
| 52 | UHMK1 | 0.77497540 |
| 53 | CHEK1 | 0.75785144 |
| 54 | RET | 0.75161697 |
| 55 | CDK8 | 0.74047931 |
| 56 | HIPK2 | 0.73904551 |
| 57 | ZAP70 | 0.72077871 |
| 58 | PAK2 | 0.71972315 |
| 59 | KSR2 | 0.71493262 |
| 60 | DYRK1B | 0.70868147 |
| 61 | PDGFRB | 0.70803962 |
| 62 | CAMKK1 | 0.70787680 |
| 63 | CLK1 | 0.68986201 |
| 64 | ATR | 0.68736957 |
| 65 | ILK | 0.68701888 |
| 66 | FGFR4 | 0.66413149 |
| 67 | CDK2 | 0.65631251 |
| 68 | STK4 | 0.65616442 |
| 69 | MARK2 | 0.64790179 |
| 70 | PRKCH | 0.64255773 |
| 71 | AURKA | 0.62752033 |
| 72 | RPS6KA2 | 0.62448318 |
| 73 | BUB1 | 0.62081380 |
| 74 | CAMK1G | 0.61803235 |
| 75 | MAPK11 | 0.61418025 |
| 76 | BTK | 0.61221592 |
| 77 | DDR2 | 0.61189452 |
| 78 | VRK2 | 0.61025019 |
| 79 | MAP2K3 | 0.60772344 |
| 80 | MAP3K9 | 0.58068020 |
| 81 | TGFBR1 | 0.57745095 |
| 82 | BRSK1 | 0.55727994 |
| 83 | RPS6KC1 | 0.55307640 |
| 84 | RPS6KL1 | 0.55307640 |
| 85 | MAP3K3 | 0.54485107 |
| 86 | RPS6KA1 | 0.54336692 |
| 87 | TTK | 0.53606543 |
| 88 | PIM1 | 0.53389007 |
| 89 | IRAK4 | 0.52706822 |
| 90 | CAMK1D | 0.52197328 |
| 91 | PAK6 | 0.50363685 |
| 92 | FGFR3 | 0.48930970 |
| 93 | DMPK | 0.48907504 |
| 94 | FGFR1 | 0.48820891 |
| 95 | HCK | 0.48659853 |
| 96 | RPS6KA6 | 0.48387686 |
| 97 | CSF1R | 0.48303377 |
| 98 | KDR | 0.48148705 |
| 99 | LATS2 | 0.47554498 |
| 100 | TSSK6 | 0.45544950 |
| 101 | DAPK1 | 0.43856737 |
| 102 | CDC42BPA | 0.43825287 |
| 103 | TESK1 | 0.43743935 |
| 104 | AKT2 | 0.43399922 |
| 105 | CDK9 | 0.43201148 |
| 106 | PRKD2 | 0.43090284 |
| 107 | MAP3K11 | 0.43017148 |
| 108 | PTK2 | 0.41495677 |
| 109 | PDK1 | 0.41277484 |
| 110 | JAK2 | 0.39911443 |
| 111 | SRPK1 | 0.39380763 |
| 112 | CDK1 | 0.39375886 |
| 113 | MAPKAPK3 | 0.38905030 |
| 114 | MAP3K2 | 0.38567811 |
| 115 | TNK2 | 0.38060040 |
| 116 | PRKCI | 0.38052050 |
| 117 | CSK | 0.37972390 |
| 118 | CHEK2 | 0.36951597 |
| 119 | CSNK1D | 0.36133975 |
| 120 | CDK11A | 0.35844153 |
| 121 | SYK | 0.35290466 |
| 122 | MAPK14 | 0.35206982 |
| 123 | JAK3 | 0.35205407 |
| 124 | RPS6KB1 | 0.34926794 |
| 125 | * ATM | 0.34793489 |
| 126 | PLK1 | 0.34621118 |
| 127 | ITK | 0.33770660 |
| 128 | LMTK2 | 0.33443321 |
| 129 | AURKB | 0.32565092 |
| 130 | CDK15 | 0.32167228 |
| 131 | RAF1 | 0.31607603 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 2.27553654 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 2.21101683 |
| 3 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.94614865 |
| 4 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.85573809 |
| 5 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.83956090 |
| 6 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.80155911 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 1.71694597 |
| 8 | Lysine degradation_Homo sapiens_hsa00310 | 1.70332850 |
| 9 | Sulfur relay system_Homo sapiens_hsa04122 | 1.68192620 |
| 10 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.64117733 |
| 11 | Mismatch repair_Homo sapiens_hsa03430 | 1.60352400 |
| 12 | Endometrial cancer_Homo sapiens_hsa05213 | 1.57656220 |
| 13 | Colorectal cancer_Homo sapiens_hsa05210 | 1.57099603 |
| 14 | Cell cycle_Homo sapiens_hsa04110 | 1.55063671 |
| 15 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.53299561 |
| 16 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.52975841 |
| 17 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.52519916 |
| 18 | Base excision repair_Homo sapiens_hsa03410 | 1.51403892 |
| 19 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.47065966 |
| 20 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.47065406 |
| 21 | RNA transport_Homo sapiens_hsa03013 | 1.45571770 |
| 22 | Other glycan degradation_Homo sapiens_hsa00511 | 1.45448198 |
| 23 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.45225714 |
| 24 | Glioma_Homo sapiens_hsa05214 | 1.44439053 |
| 25 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.43166940 |
| 26 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.42937503 |
| 27 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.41497982 |
| 28 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.37406850 |
| 29 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.35756655 |
| 30 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.34781531 |
| 31 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.31170024 |
| 32 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.28895490 |
| 33 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.28021506 |
| 34 | Thyroid cancer_Homo sapiens_hsa05216 | 1.27771539 |
| 35 | HTLV-I infection_Homo sapiens_hsa05166 | 1.26542673 |
| 36 | Bladder cancer_Homo sapiens_hsa05219 | 1.25767518 |
| 37 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.20650308 |
| 38 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.18031327 |
| 39 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.17529085 |
| 40 | Prion diseases_Homo sapiens_hsa05020 | 1.14359352 |
| 41 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.13476435 |
| 42 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.11940504 |
| 43 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.10048333 |
| 44 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.05678330 |
| 45 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.02026150 |
| 46 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.01184277 |
| 47 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.98881196 |
| 48 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.97808444 |
| 49 | Insulin resistance_Homo sapiens_hsa04931 | 0.97400676 |
| 50 | Viral myocarditis_Homo sapiens_hsa05416 | 0.97196519 |
| 51 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.97095517 |
| 52 | Ribosome_Homo sapiens_hsa03010 | 0.95970137 |
| 53 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.93716285 |
| 54 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.93465896 |
| 55 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.92931973 |
| 56 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.92691061 |
| 57 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.91644835 |
| 58 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.91421981 |
| 59 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.91336270 |
| 60 | Adherens junction_Homo sapiens_hsa04520 | 0.90508578 |
| 61 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.90232503 |
| 62 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.89997959 |
| 63 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.88926600 |
| 64 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.88427421 |
| 65 | Alcoholism_Homo sapiens_hsa05034 | 0.86256798 |
| 66 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.85776595 |
| 67 | Focal adhesion_Homo sapiens_hsa04510 | 0.85275467 |
| 68 | Carbon metabolism_Homo sapiens_hsa01200 | 0.84872717 |
| 69 | Platelet activation_Homo sapiens_hsa04611 | 0.84767233 |
| 70 | Hepatitis B_Homo sapiens_hsa05161 | 0.84144689 |
| 71 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.83909715 |
| 72 | Galactose metabolism_Homo sapiens_hsa00052 | 0.81472352 |
| 73 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.80389956 |
| 74 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.80232411 |
| 75 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.79302664 |
| 76 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.79090941 |
| 77 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.78279225 |
| 78 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.78153032 |
| 79 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.77478613 |
| 80 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.77426154 |
| 81 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.77215684 |
| 82 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.76712150 |
| 83 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.76617149 |
| 84 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.76000807 |
| 85 | Apoptosis_Homo sapiens_hsa04210 | 0.73621650 |
| 86 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.73537328 |
| 87 | Prostate cancer_Homo sapiens_hsa05215 | 0.72426044 |
| 88 | Melanoma_Homo sapiens_hsa05218 | 0.72412182 |
| 89 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.72119109 |
| 90 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.72082182 |
| 91 | Melanogenesis_Homo sapiens_hsa04916 | 0.71966884 |
| 92 | Pathways in cancer_Homo sapiens_hsa05200 | 0.70729124 |
| 93 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.68809026 |
| 94 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.68323687 |
| 95 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.67614146 |
| 96 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.67270493 |
| 97 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.65566401 |
| 98 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.65462761 |
| 99 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.64853311 |
| 100 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.64666963 |
| 101 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.64507723 |
| 102 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.63140138 |
| 103 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.63054944 |
| 104 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.62765165 |
| 105 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.62491567 |
| 106 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.61857138 |
| 107 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.61750764 |
| 108 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.61668710 |
| 109 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.61458811 |
| 110 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.61370586 |
| 111 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.60207652 |
| 112 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.59252031 |
| 113 | Endocytosis_Homo sapiens_hsa04144 | 0.58570452 |
| 114 | Shigellosis_Homo sapiens_hsa05131 | 0.58524571 |
| 115 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.58413105 |
| 116 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.57955592 |
| 117 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.57474905 |
| 118 | Hepatitis C_Homo sapiens_hsa05160 | 0.57291761 |
| 119 | Gap junction_Homo sapiens_hsa04540 | 0.55519972 |
| 120 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.54923271 |
| 121 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.54661039 |
| 122 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.53356773 |
| 123 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.53147081 |
| 124 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.53011866 |
| 125 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.52099131 |
| 126 | Long-term potentiation_Homo sapiens_hsa04720 | 0.51995676 |
| 127 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.49102355 |
| 128 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.48513446 |
| 129 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.43399662 |
| 130 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.41949233 |

