MB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.70863792
2cardiac myofibril assembly (GO:0055003)8.71063375
3* skeletal muscle contraction (GO:0003009)8.00403254
4myofibril assembly (GO:0030239)7.97373830
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.80571335
6actin-myosin filament sliding (GO:0033275)7.21847559
7muscle filament sliding (GO:0030049)7.21847559
8negative regulation of potassium ion transmembrane transport (GO:1901380)7.13383133
9plasma membrane repair (GO:0001778)6.85703898
10cardiac muscle contraction (GO:0060048)6.83730074
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.83478462
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.60008632
13cardiac muscle cell development (GO:0055013)6.46226067
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.37781966
15tricarboxylic acid cycle (GO:0006099)6.29635936
16regulation of actin filament-based movement (GO:1903115)6.25574469
17cardiac cell development (GO:0055006)6.07083473
18actomyosin structure organization (GO:0031032)5.99121297
19adult heart development (GO:0007512)5.98958375
20response to muscle activity (GO:0014850)5.95293155
21regulation of skeletal muscle contraction (GO:0014819)5.94440282
22actin-mediated cell contraction (GO:0070252)5.93471424
23regulation of relaxation of muscle (GO:1901077)5.91667162
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.82742602
25ventricular cardiac muscle cell action potential (GO:0086005)5.81432097
26bundle of His cell to Purkinje myocyte communication (GO:0086069)5.78647908
27ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.76288596
28cardiac muscle tissue morphogenesis (GO:0055008)5.75548379
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.65189223
30cardiac muscle hypertrophy (GO:0003300)5.36901491
31* striated muscle contraction (GO:0006941)5.19472691
32carnitine shuttle (GO:0006853)5.18519577
33muscle tissue morphogenesis (GO:0060415)5.17691681
34regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.17631611
35sarcoplasmic reticulum calcium ion transport (GO:0070296)5.15854144
36heart trabecula formation (GO:0060347)5.14590900
37striated muscle hypertrophy (GO:0014897)5.10513578
38regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.04301981
39regulation of sarcomere organization (GO:0060297)5.01654033
40regulation of striated muscle contraction (GO:0006942)5.00377383
41skeletal muscle fiber development (GO:0048741)4.99720826
42* muscle system process (GO:0003012)4.95439237
43regulation of cell communication by electrical coupling (GO:0010649)4.90641640
44heart process (GO:0003015)4.88982790
45heart contraction (GO:0060047)4.88982790
46skeletal muscle adaptation (GO:0043501)4.88834965
47regulation of the force of heart contraction (GO:0002026)4.84114997
48regulation of acyl-CoA biosynthetic process (GO:0050812)4.71472401
49cell communication involved in cardiac conduction (GO:0086065)4.67143834
50regulation of membrane repolarization (GO:0060306)4.66405465
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.55978818
52myotube cell development (GO:0014904)4.55733600
53striated muscle adaptation (GO:0014888)4.55250523
54response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.53280283
55muscle hypertrophy (GO:0014896)4.51606924
56glycogen catabolic process (GO:0005980)4.50394636
57actin filament-based movement (GO:0030048)4.48064537
58fatty acid transmembrane transport (GO:1902001)4.43863747
59muscle fiber development (GO:0048747)4.36596790
60regulation of cardiac muscle cell contraction (GO:0086004)4.30171452
61regulation of cofactor metabolic process (GO:0051193)4.27844075
62regulation of coenzyme metabolic process (GO:0051196)4.27844075
63mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.23223958
64glucan catabolic process (GO:0009251)4.23080855
65glucan biosynthetic process (GO:0009250)4.20632476
66glycogen biosynthetic process (GO:0005978)4.20632476
67creatine metabolic process (GO:0006600)4.18805425
68regulation of cardiac muscle contraction (GO:0055117)4.16060733
69positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.09534127
70regulation of heart rate (GO:0002027)4.07742507
71NADH metabolic process (GO:0006734)4.05469189
72cardiac muscle cell action potential involved in contraction (GO:0086002)4.02761586
732-oxoglutarate metabolic process (GO:0006103)4.00715940
74negative regulation of protein localization to cell surface (GO:2000009)3.99719143
75regulation of ATPase activity (GO:0043462)3.99527552
76regulation of ATP catabolic process (GO:1903289)3.99527552
77skeletal muscle tissue development (GO:0007519)3.97877445
78cellular polysaccharide catabolic process (GO:0044247)3.96523641
79cardiac muscle cell action potential (GO:0086001)3.96479220
80negative regulation of potassium ion transport (GO:0043267)3.96143593
81ATP synthesis coupled proton transport (GO:0015986)3.94947974
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94947974
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.94145779
84cell communication by electrical coupling (GO:0010644)3.90869399
85cardiac muscle adaptation (GO:0014887)3.84595718
86cardiac muscle hypertrophy in response to stress (GO:0014898)3.84595718
87muscle hypertrophy in response to stress (GO:0003299)3.84595718
88carnitine transmembrane transport (GO:1902603)3.84357318
89regulation of sequestering of triglyceride (GO:0010889)3.82350781
90regulation of heart contraction (GO:0008016)3.81420551
91respiratory electron transport chain (GO:0022904)3.78303245
92positive regulation of heart rate (GO:0010460)3.72467410
93negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.72386275
94negative regulation of calcium ion transmembrane transport (GO:1903170)3.72386275
95muscle adaptation (GO:0043500)3.70455799
96relaxation of cardiac muscle (GO:0055119)3.69209196
97negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.68312528
98striated muscle cell development (GO:0055002)3.67328562
99electron transport chain (GO:0022900)3.66545996
100muscle cell cellular homeostasis (GO:0046716)3.66316301
101positive regulation of cation channel activity (GO:2001259)3.64463852
102negative regulation of striated muscle cell apoptotic process (GO:0010664)3.64240519
103regulation of cardioblast differentiation (GO:0051890)3.63573656
104positive regulation of heart contraction (GO:0045823)3.62076062
105response to inactivity (GO:0014854)3.59376686
106oxidative phosphorylation (GO:0006119)3.56605725
107polysaccharide catabolic process (GO:0000272)3.56352061
108negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.51349219
109* muscle contraction (GO:0006936)3.51132369
110carnitine transport (GO:0015879)3.49854347
111amino-acid betaine transport (GO:0015838)3.49854347
112membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48948517
113regulation of sulfur metabolic process (GO:0042762)3.48750642
114regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.45777883
115regulation of muscle system process (GO:0090257)3.45415395
116cardiac conduction (GO:0061337)3.44485526
117regulation of calcium ion transmembrane transport (GO:1903169)3.43289853
118regulation of calcium ion transmembrane transporter activity (GO:1901019)3.43289853
119skeletal muscle tissue regeneration (GO:0043403)3.43072116
120glycogen metabolic process (GO:0005977)3.39435697
121regulation of heart rate by cardiac conduction (GO:0086091)3.38824521
122striated muscle atrophy (GO:0014891)3.38578368
123ventricular cardiac muscle cell development (GO:0055015)3.36722011
124gluconeogenesis (GO:0006094)3.34486329
125aspartate family amino acid catabolic process (GO:0009068)3.34331993
126regulation of fatty acid oxidation (GO:0046320)3.33825146
127regulation of muscle contraction (GO:0006937)3.32931696
128muscle cell fate commitment (GO:0042693)3.32877912
129glucan metabolic process (GO:0044042)3.32635649
130cellular glucan metabolic process (GO:0006073)3.32635649
131muscle organ development (GO:0007517)3.32025718
132muscle structure development (GO:0061061)3.31545806
133muscle cell development (GO:0055001)3.30754134
134relaxation of muscle (GO:0090075)3.29623692
135positive regulation of myotube differentiation (GO:0010831)3.28837878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.55456995
2* EP300_21415370_ChIP-Seq_HL-1_Mouse4.41358791
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.22293273
4* TBX20_22328084_ChIP-Seq_HEART_Mouse4.05370744
5* TBX20_22080862_ChIP-Seq_HEART_Mouse4.05370744
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.01434157
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.76052491
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.56791150
9ZNF263_19887448_ChIP-Seq_K562_Human3.47543453
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.87430033
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.83422069
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.45018200
13EZH2_22144423_ChIP-Seq_EOC_Human2.44487813
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.44093981
15* ESR1_20079471_ChIP-ChIP_T-47D_Human2.34056833
16GATA4_21415370_ChIP-Seq_HL-1_Mouse2.23124026
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11250954
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.09654448
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02501771
20* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.01120419
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83456892
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80941109
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80202504
24PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.79670836
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66373450
26* ESR2_21235772_ChIP-Seq_MCF-7_Human1.66229295
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65205177
28CLOCK_20551151_ChIP-Seq_293T_Human1.64369695
29NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.63040879
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55458742
31CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47621361
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47439711
33NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46831556
34DROSHA_22980978_ChIP-Seq_HELA_Human1.40958588
35* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40778675
36CTCF_27219007_Chip-Seq_Bcells_Human1.40500659
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40110944
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38286592
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38285566
40KDM2B_26808549_Chip-Seq_DND41_Human1.38172459
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.34970051
42* LXR_22292898_ChIP-Seq_THP-1_Human1.33888490
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32356646
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31953548
45TP63_22573176_ChIP-Seq_HFKS_Human1.29696977
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.23015184
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21299154
48GATA1_19941826_ChIP-Seq_K562_Human1.20916807
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.19851096
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18664963
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17202545
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15530282
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.15304797
54RACK7_27058665_Chip-Seq_MCF-7_Human1.15023313
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.14651583
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.13114566
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12913905
58STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12788538
59P68_20966046_ChIP-Seq_HELA_Human1.12675942
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12448739
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11608064
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.08953610
63ATF3_27146783_Chip-Seq_COLON_Human1.07466728
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06990509
65* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06768362
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06476735
67* RUNX1_27514584_Chip-Seq_MCF-7_Human1.04083923
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02522367
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01638489
70MYC_27129775_Chip-Seq_CORNEA_Mouse0.99842962
71SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98475530
72GATA1_19941827_ChIP-Seq_MEL_Mouse0.98401423
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97486291
74ISL1_27105846_Chip-Seq_CPCs_Mouse0.96532738
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96347359
76CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95732952
77* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94863702
78GATA1_22025678_ChIP-Seq_K562_Human0.94637372
79FOXA2_19822575_ChIP-Seq_HepG2_Human0.94581391
80AR_21572438_ChIP-Seq_LNCaP_Human0.94346651
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93638379
82NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93116667
83GATA2_19941826_ChIP-Seq_K562_Human0.93063582
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92309236
85BCL6_27268052_Chip-Seq_Bcells_Human0.91611985
86KDM2B_26808549_Chip-Seq_K562_Human0.91478241
87OCT4_20526341_ChIP-Seq_ESCs_Human0.91369106
88GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91331481
89BCOR_27268052_Chip-Seq_Bcells_Human0.90760399
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90614803
91* SPI1_20517297_ChIP-Seq_HL60_Human0.90436813
92SPI1_23127762_ChIP-Seq_K562_Human0.89552539
93TP53_23651856_ChIP-Seq_MEFs_Mouse0.89101062
94CTCF_21964334_Chip-Seq_Bcells_Human0.86986427
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86671645
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85909661
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85783448
98SMC4_20622854_ChIP-Seq_HELA_Human0.84237731
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83003929
100PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.82989209
101CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82558961
102CBX2_27304074_Chip-Seq_ESCs_Mouse0.82537586
103FOXH1_21741376_ChIP-Seq_ESCs_Human0.82466146
104ESR1_21235772_ChIP-Seq_MCF-7_Human0.82155357
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.82091478
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81979155
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81973942
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81606415
109MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81545648
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.79814839
111YY1_22570637_ChIP-Seq_MALME-3M_Human0.79311952
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79210364
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79195197
114VDR_22108803_ChIP-Seq_LS180_Human0.78883878
115SMC1_22415368_ChIP-Seq_MEFs_Mouse0.78592946
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78245036
117SA1_27219007_Chip-Seq_Bcells_Human0.78079554
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77689990
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77305894
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77179345
121RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76610483
122CRX_20693478_ChIP-Seq_RETINA_Mouse0.76366325
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74217692
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.73566444
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73364891
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.73073465
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.71782419
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70166971
129GF1_26923725_Chip-Seq_HPCs_Mouse0.69888930
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.68888772
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.68757518
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67797569
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67797569
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.65777080
135CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.65425957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.84295261
2MP0004084_abnormal_cardiac_muscle5.89101880
3MP0000751_myopathy5.44644086
4MP0004215_abnormal_myocardial_fiber4.88630924
5MP0004036_abnormal_muscle_relaxation4.36584844
6* MP0003646_muscle_fatigue4.24188429
7MP0005330_cardiomyopathy3.96254861
8MP0000749_muscle_degeneration3.94898506
9MP0004087_abnormal_muscle_fiber3.16380194
10* MP0002972_abnormal_cardiac_muscle3.05018325
11MP0003137_abnormal_impulse_conducting2.93503792
12MP0008775_abnormal_heart_ventricle2.89264236
13MP0000750_abnormal_muscle_regeneration2.86404269
14MP0005620_abnormal_muscle_contractility2.70381830
15MP0001544_abnormal_cardiovascular_syste2.66902960
16MP0005385_cardiovascular_system_phenoty2.66902960
17MP0010630_abnormal_cardiac_muscle2.62613807
18MP0002106_abnormal_muscle_physiology2.56984166
19MP0004130_abnormal_muscle_cell2.49789511
20MP0004484_altered_response_of2.45409951
21MP0002269_muscular_atrophy2.36117862
22MP0003828_pulmonary_edema2.27180184
23* MP0006138_congestive_heart_failure2.12157934
24MP0004085_abnormal_heartbeat2.12147804
25MP0005369_muscle_phenotype2.09596712
26MP0004145_abnormal_muscle_electrophysio2.04914898
27MP0000747_muscle_weakness2.01597983
28* MP0000759_abnormal_skeletal_muscle1.96924100
29MP0003221_abnormal_cardiomyocyte_apopto1.90995317
30MP0004510_myositis1.86036400
31MP0004233_abnormal_muscle_weight1.71487160
32MP0006036_abnormal_mitochondrial_physio1.65068079
33MP0002127_abnormal_cardiovascular_syste1.58968145
34MP0005666_abnormal_adipose_tissue1.55506216
35MP0003950_abnormal_plasma_membrane1.49826851
36MP0002332_abnormal_exercise_endurance1.42476804
37MP0005670_abnormal_white_adipose1.41472817
38MP0000343_altered_response_to1.23772571
39MP0010368_abnormal_lymphatic_system1.17615409
40MP0002234_abnormal_pharynx_morphology1.16346643
41MP0003567_abnormal_fetal_cardiomyocyte1.14653942
42MP0003279_aneurysm1.13744764
43MP0000266_abnormal_heart_morphology1.13678870
44MP0004185_abnormal_adipocyte_glucose1.11415411
45MP0005165_increased_susceptibility_to1.10160292
46MP0005375_adipose_tissue_phenotype1.07584869
47MP0001661_extended_life_span0.98149559
48MP0004270_analgesia0.96716293
49MP0006035_abnormal_mitochondrial_morpho0.91630006
50MP0002108_abnormal_muscle_morphology0.91470643
51MP0003705_abnormal_hypodermis_morpholog0.87171916
52MP0005623_abnormal_meninges_morphology0.81602592
53MP0000230_abnormal_systemic_arterial0.81323248
54* MP0002128_abnormal_blood_circulation0.76821347
55MP0003566_abnormal_cell_adhesion0.75734698
56MP0002909_abnormal_adrenal_gland0.74611117
57MP0003806_abnormal_nucleotide_metabolis0.68213184
58MP0000767_abnormal_smooth_muscle0.65176324
59MP0001879_abnormal_lymphatic_vessel0.64950711
60MP0000003_abnormal_adipose_tissue0.63380032
61MP0000733_abnormal_muscle_development0.62840319
62* MP0005266_abnormal_metabolism0.61288984
63MP0000013_abnormal_adipose_tissue0.60587809
64MP0005187_abnormal_penis_morphology0.59261707
65MP0008438_abnormal_cutaneous_collagen0.57314463
66MP0004043_abnormal_pH_regulation0.54376570
67MP0002971_abnormal_brown_adipose0.53923030
68MP0005451_abnormal_body_composition0.52103009
69MP0005319_abnormal_enzyme/_coenzyme0.50420424
70MP0005275_abnormal_skin_tensile0.49369961
71MP0008569_lethality_at_weaning0.49079089
72MP0002078_abnormal_glucose_homeostasis0.47898600
73MP0004147_increased_porphyrin_level0.46523833
74MP0001299_abnormal_eye_distance/0.44657807
75MP0004272_abnormal_basement_membrane0.43994057
76MP0008961_abnormal_basal_metabolism0.43972617
77MP0003656_abnormal_erythrocyte_physiolo0.43916137
78MP0002638_abnormal_pupillary_reflex0.41051944
79MP0000372_irregular_coat_pigmentation0.40875128
80* MP0002925_abnormal_cardiovascular_devel0.40644673
81MP0009840_abnormal_foam_cell0.40410809
82MP0005584_abnormal_enzyme/coenzyme_acti0.37431574
83MP0003879_abnormal_hair_cell0.35015980
84MP0005535_abnormal_body_temperature0.34272523
85MP0001784_abnormal_fluid_regulation0.33270365
86* MP0001614_abnormal_blood_vessel0.32012078
87MP0001958_emphysema0.31176177
88MP0005083_abnormal_biliary_tract0.30378540
89MP0005334_abnormal_fat_pad0.29981304
90MP0000762_abnormal_tongue_morphology0.29611009
91MP0005167_abnormal_blood-brain_barrier0.29524189
92MP0002822_catalepsy0.29419520
93MP0004134_abnormal_chest_morphology0.28997105
94* MP0003984_embryonic_growth_retardation0.28691533
95MP0005332_abnormal_amino_acid0.28343116
96MP0004924_abnormal_behavior0.28311073
97MP0005386_behavior/neurological_phenoty0.28311073
98MP0002118_abnormal_lipid_homeostasis0.27708030
99* MP0002088_abnormal_embryonic_growth/wei0.27255184
100MP0005166_decreased_susceptibility_to0.27203451
101MP0005452_abnormal_adipose_tissue0.27128278
102MP0005595_abnormal_vascular_smooth0.26468598
103* MP0005376_homeostasis/metabolism_phenot0.25987002
104MP0009115_abnormal_fat_cell0.25166939
105MP0002295_abnormal_pulmonary_circulatio0.24117673
106MP0000249_abnormal_blood_vessel0.23799596
107MP0004142_abnormal_muscle_tone0.23533185
108* MP0003948_abnormal_gas_homeostasis0.23452056
109MP0009780_abnormal_chondrocyte_physiolo0.23236749
110MP0001727_abnormal_embryo_implantation0.23179680
111MP0009672_abnormal_birth_weight0.23082019
112MP0003045_fibrosis0.22481073
113MP0009384_cardiac_valve_regurgitation0.22476567
114MP0005423_abnormal_somatic_nervous0.22332371
115MP0010030_abnormal_orbit_morphology0.21689163
116MP0008874_decreased_physiological_sensi0.21653676
117MP0002896_abnormal_bone_mineralization0.21464595
118MP0001853_heart_inflammation0.21125480
119MP0000579_abnormal_nail_morphology0.21122318
120MP0002877_abnormal_melanocyte_morpholog0.20918947
121MP0002114_abnormal_axial_skeleton0.19632111
122MP0002066_abnormal_motor_capabilities/c0.17106450
123MP0001346_abnormal_lacrimal_gland0.16492497
124MP0001943_abnormal_respiration0.15258405

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)9.95192073
2Sudden death (HP:0001699)8.27153897
3Ventricular tachycardia (HP:0004756)7.16197209
4Calf muscle hypertrophy (HP:0008981)6.62337328
5Muscle fiber splitting (HP:0003555)6.09312087
6Atrial fibrillation (HP:0005110)6.09178881
7Muscle hypertrophy of the lower extremities (HP:0008968)6.07388969
8Exercise-induced myalgia (HP:0003738)5.85409589
9Exercise-induced muscle cramps (HP:0003710)5.79100876
10Primary atrial arrhythmia (HP:0001692)5.70266027
11Supraventricular tachycardia (HP:0004755)5.51780294
12Lipoatrophy (HP:0100578)5.48252259
13Abnormality of the calf musculature (HP:0001430)5.44252179
14Supraventricular arrhythmia (HP:0005115)5.41040498
15Hyporeflexia of lower limbs (HP:0002600)5.32008611
16Right ventricular cardiomyopathy (HP:0011663)5.12045309
17Abnormality of the left ventricular outflow tract (HP:0011103)5.09880914
18Subaortic stenosis (HP:0001682)5.09880914
19Myopathic facies (HP:0002058)5.04375858
20Distal arthrogryposis (HP:0005684)4.93952329
21Centrally nucleated skeletal muscle fibers (HP:0003687)4.86714751
22Bundle branch block (HP:0011710)4.81108689
23Myoglobinuria (HP:0002913)4.71256493
24Syncope (HP:0001279)4.70449592
25Dilated cardiomyopathy (HP:0001644)4.56974688
26Palpitations (HP:0001962)4.48700569
27EMG: myopathic abnormalities (HP:0003458)4.42065271
28Prolonged QT interval (HP:0001657)4.31648471
29Increased connective tissue (HP:0009025)4.27750888
30Asymmetric septal hypertrophy (HP:0001670)4.18263069
31Round ear (HP:0100830)4.11953272
32Heart block (HP:0012722)3.96933955
33Ventricular arrhythmia (HP:0004308)3.93517498
34Atrioventricular block (HP:0001678)3.88352610
35Ulnar deviation of the wrist (HP:0003049)3.80433563
36Difficulty running (HP:0009046)3.78271114
37Abnormal atrioventricular conduction (HP:0005150)3.75498281
38Ventricular fibrillation (HP:0001663)3.72747531
39Myotonia (HP:0002486)3.63340965
40Rhabdomyolysis (HP:0003201)3.56552797
41Frequent falls (HP:0002359)3.31209835
42Calcaneovalgus deformity (HP:0001848)3.29072678
43Difficulty climbing stairs (HP:0003551)3.17098551
44Abnormal EKG (HP:0003115)3.07936885
45Absent phalangeal crease (HP:0006109)2.95964084
46Left ventricular hypertrophy (HP:0001712)2.91779998
47Deformed tarsal bones (HP:0008119)2.90252959
48Hepatic necrosis (HP:0002605)2.80903253
49Distal lower limb muscle weakness (HP:0009053)2.79237486
50Abnormal mitochondria in muscle tissue (HP:0008316)2.78520386
51Testicular atrophy (HP:0000029)2.78132129
52Acute necrotizing encephalopathy (HP:0006965)2.75343712
53Ketoacidosis (HP:0001993)2.75285660
54Palmoplantar keratoderma (HP:0000982)2.74050157
55Increased variability in muscle fiber diameter (HP:0003557)2.69567654
56Limb-girdle muscle atrophy (HP:0003797)2.67902085
57Bulbar palsy (HP:0001283)2.65199532
58Type 1 muscle fiber predominance (HP:0003803)2.62260408
59Areflexia of lower limbs (HP:0002522)2.56648592
60Progressive muscle weakness (HP:0003323)2.49796604
61Abnormality of skeletal muscle fiber size (HP:0012084)2.49663089
62Malignant hyperthermia (HP:0002047)2.48811391
63Hepatocellular necrosis (HP:0001404)2.47433148
64Neck muscle weakness (HP:0000467)2.46633185
65Muscle stiffness (HP:0003552)2.46168086
66Abnormal finger flexion creases (HP:0006143)2.42806441
67Hypoglycemic coma (HP:0001325)2.41114929
68Acute encephalopathy (HP:0006846)2.38949667
69Increased muscle lipid content (HP:0009058)2.36678729
70Muscle fiber inclusion bodies (HP:0100299)2.36370504
71Weak cry (HP:0001612)2.36018524
72Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.32992115
73Abnormality of fatty-acid metabolism (HP:0004359)2.28977155
74Distal lower limb amyotrophy (HP:0008944)2.26008309
75Progressive macrocephaly (HP:0004481)2.25953113
76Mitochondrial inheritance (HP:0001427)2.25485275
77Cerebral edema (HP:0002181)2.22761752
78Conjunctival hamartoma (HP:0100780)2.22757057
79Abnormality of the foot musculature (HP:0001436)2.22702791
80Ragged-red muscle fibers (HP:0003200)2.22294814
81Slender build (HP:0001533)2.21610293
82Dicarboxylic aciduria (HP:0003215)2.21558158
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21558158
84Mildly elevated creatine phosphokinase (HP:0008180)2.15363920
85Foot dorsiflexor weakness (HP:0009027)2.11209380
86Increased CSF lactate (HP:0002490)2.09641020
87Dysmetric saccades (HP:0000641)2.08541890
88Sudden cardiac death (HP:0001645)2.07661127
89Spinal rigidity (HP:0003306)2.07231423
90Large for gestational age (HP:0001520)2.06947770
91Ketosis (HP:0001946)2.04861195
92Waddling gait (HP:0002515)2.04654868
93Abnormality of the shoulder girdle musculature (HP:0001435)2.04264556
94Congestive heart failure (HP:0001635)2.03489261
95EMG: neuropathic changes (HP:0003445)2.03220964
96Rimmed vacuoles (HP:0003805)2.02991043
97Increased intramyocellular lipid droplets (HP:0012240)2.02891963
98Hip contracture (HP:0003273)2.01086808
99Muscular dystrophy (HP:0003560)2.00987802
100Exercise intolerance (HP:0003546)2.00032941
101Hypoplastic ischia (HP:0003175)1.99872922
102Pheochromocytoma (HP:0002666)1.98692336
103Gowers sign (HP:0003391)1.97373962
104Fetal akinesia sequence (HP:0001989)1.95859659
105Respiratory failure (HP:0002878)1.94580984
106Lactic acidosis (HP:0003128)1.93594608
107Hyperinsulinemic hypoglycemia (HP:0000825)1.92981315
108Hyperkalemia (HP:0002153)1.92441767
109Fatigable weakness (HP:0003473)1.91841883
110Abnormality of the neuromuscular junction (HP:0003398)1.91841883
111Hamartoma of the eye (HP:0010568)1.90887364
112Facial diplegia (HP:0001349)1.88434581
113Generalized muscle weakness (HP:0003324)1.84920874
114Scapular winging (HP:0003691)1.84480612
115Neoplasm of head and neck (HP:0012288)1.84204032
116Esophageal neoplasm (HP:0100751)1.84204032
117Respiratory insufficiency due to muscle weakness (HP:0002747)1.83796016
118Abnormality of the calcaneus (HP:0008364)1.82439648
119Broad metatarsal (HP:0001783)1.78378795
120Neuroendocrine neoplasm (HP:0100634)1.75842287
121Lower limb amyotrophy (HP:0007210)1.75520492
122Abnormality of the ischium (HP:0003174)1.73073388
123Proximal amyotrophy (HP:0007126)1.72348010
124Abnormality of alanine metabolism (HP:0010916)1.68914833
125Hyperalaninemia (HP:0003348)1.68914833
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68914833
127Limb-girdle muscle weakness (HP:0003325)1.61334524
128Steppage gait (HP:0003376)1.56053755
129Abnormality of the hip-girdle musculature (HP:0001445)1.48248744
130Abnormality of the musculature of the pelvis (HP:0001469)1.48248744
131Shoulder girdle muscle weakness (HP:0003547)1.38394920
132Pelvic girdle muscle weakness (HP:0003749)1.38135790
133Limited hip movement (HP:0008800)1.33660515
134Nonprogressive disorder (HP:0003680)1.33192972
135Paralysis (HP:0003470)1.29990745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.39995454
2PHKG14.21947217
3PHKG24.21947217
4LMTK24.19129672
5OBSCN4.09754112
6MYLK3.66446898
7PDK43.25732548
8PDK33.25732548
9DMPK3.11648724
10PKN22.82417844
11TRIB32.81810433
12MUSK2.65229812
13BCKDK2.55938045
14PIK3CA2.33759516
15NEK12.12681181
16PINK12.08579088
17TIE12.07372489
18PDK21.96102523
19PAK31.51121384
20STK241.42859479
21PRKD11.41108182
22CAMK2D1.35104624
23GRK71.29482907
24MARK11.12910475
25ILK1.06313904
26LIMK11.05542692
27MAPKAPK31.04530634
28ROCK11.04133814
29STK41.03979901
30MAPK121.03336267
31MAP3K71.02073597
32CDC42BPA1.01520541
33RIPK11.00673619
34MAP2K40.95898762
35MAP3K50.91571388
36WNK40.89532249
37PKN10.89485652
38EEF2K0.89378579
39PRKAA10.86725206
40MAP2K30.85739701
41PDGFRA0.83590792
42DAPK30.81236186
43PRKAA20.80011207
44EPHB10.76360610
45TRPM70.73730643
46INSRR0.73696015
47FLT30.70235034
48ROCK20.70178927
49CAMK40.69455380
50MOS0.68371713
51MAP2K60.68045014
52RPS6KC10.68030156
53RPS6KL10.68030156
54STK380.67888707
55MAP3K30.67258918
56STK38L0.66401207
57KDR0.62316757
58DYRK1B0.62135536
59TGFBR20.61697266
60ZAK0.61324882
61CCNB10.61269957
62CAMK2A0.59620440
63ICK0.59368167
64RPS6KA60.59166360
65ERBB30.57385170
66MAPK40.56016705
67MAP3K60.54667580
68PRKACB0.52416572
69WNK10.51489303
70MAP2K10.50802056
71NME10.50377254
72CAMK2B0.49927032
73PTK2B0.48816944
74PRKCE0.48030695
75SIK10.43985747
76KSR20.42385233
77CAMK10.41900795
78PRKACG0.40403537
79PDPK10.39773200
80PRKACA0.39538397
81MAP3K130.39197256
82PTK60.36655663
83PRKCH0.36507720
84AKT20.35213215
85CAMK2G0.33804550
86PDK10.29142440
87RPS6KA10.28610253
88TBK10.27777660
89SGK20.27173674
90PRPF4B0.26679066
91EPHB20.26488583
92MTOR0.26448774
93TAOK10.26386484
94PRKD30.26324597
95FER0.26021566
96NME20.25395656
97TAOK20.24723036
98NEK90.23997587
99FGFR40.23165231
100LATS20.22829698
101JAK10.22503573
102PRKG20.21948741
103SGK30.21762271
104MAPK100.21536482
105STK390.20924790
106RPS6KA20.19444770
107RET0.18906655
108EPHA30.18540393
109PRKG10.17244651
110RPS6KB20.17092555
111RPS6KA30.16311490
112ZAP700.16037603
113SGK10.16002640
114MARK20.15185519
115MAP3K10.14317808
116LRRK20.13983428
117RPS6KB10.13838067
118MAPK110.13559236
119PIK3CG0.13230478
120PAK60.13035341
121ARAF0.12446612
122MAPK70.12271316
123PDGFRB0.12225120
124LATS10.11993316
125MARK30.11274887
126MAP3K110.11017021
127SGK2230.10125801
128SGK4940.10125801
129NLK0.08944295
130STK110.08800531
131RAF10.05467795

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.71164143
2Cardiac muscle contraction_Homo sapiens_hsa042604.36184340
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.31497357
4Dilated cardiomyopathy_Homo sapiens_hsa054143.93477313
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.81554380
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.58804244
7Propanoate metabolism_Homo sapiens_hsa006403.18028206
8Parkinsons disease_Homo sapiens_hsa050123.09279235
9Oxidative phosphorylation_Homo sapiens_hsa001903.01773852
10Fatty acid degradation_Homo sapiens_hsa000712.82827725
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.49204862
12Carbon metabolism_Homo sapiens_hsa012002.40127296
13Alzheimers disease_Homo sapiens_hsa050102.31162903
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21967323
15Fatty acid metabolism_Homo sapiens_hsa012122.14764953
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.12074493
17Viral myocarditis_Homo sapiens_hsa054161.94859522
18Huntingtons disease_Homo sapiens_hsa050161.88948227
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78008408
20Pyruvate metabolism_Homo sapiens_hsa006201.73387638
21Pentose phosphate pathway_Homo sapiens_hsa000301.46351874
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42236180
23Butanoate metabolism_Homo sapiens_hsa006501.41716127
24Fatty acid elongation_Homo sapiens_hsa000621.21869327
25PPAR signaling pathway_Homo sapiens_hsa033201.14782553
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14691152
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09886830
28Biosynthesis of amino acids_Homo sapiens_hsa012301.09153343
29Insulin resistance_Homo sapiens_hsa049311.07090033
30Starch and sucrose metabolism_Homo sapiens_hsa005001.02964774
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.02143146
32Glucagon signaling pathway_Homo sapiens_hsa049220.99046305
33cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95279812
34Insulin signaling pathway_Homo sapiens_hsa049100.89982468
35Arginine biosynthesis_Homo sapiens_hsa002200.88778091
36Tryptophan metabolism_Homo sapiens_hsa003800.88357953
37Lysine degradation_Homo sapiens_hsa003100.84875171
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75898996
39Calcium signaling pathway_Homo sapiens_hsa040200.72589822
40beta-Alanine metabolism_Homo sapiens_hsa004100.72566648
41Arginine and proline metabolism_Homo sapiens_hsa003300.72184917
42Focal adhesion_Homo sapiens_hsa045100.71661186
43Type II diabetes mellitus_Homo sapiens_hsa049300.71411510
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69200769
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68725934
46AMPK signaling pathway_Homo sapiens_hsa041520.67788484
47HIF-1 signaling pathway_Homo sapiens_hsa040660.64297848
48Fatty acid biosynthesis_Homo sapiens_hsa000610.63316799
49Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57943926
50Long-term potentiation_Homo sapiens_hsa047200.57762875
51Oxytocin signaling pathway_Homo sapiens_hsa049210.57063773
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.56737583
53Phenylalanine metabolism_Homo sapiens_hsa003600.55077821
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54480662
55Tight junction_Homo sapiens_hsa045300.53483867
56Nitrogen metabolism_Homo sapiens_hsa009100.53168535
57Galactose metabolism_Homo sapiens_hsa000520.52192544
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51359019
59ECM-receptor interaction_Homo sapiens_hsa045120.49564749
60Peroxisome_Homo sapiens_hsa041460.48302525
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48259876
62Renin secretion_Homo sapiens_hsa049240.44190700
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.44058934
64cAMP signaling pathway_Homo sapiens_hsa040240.42162554
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42131665
66Fructose and mannose metabolism_Homo sapiens_hsa000510.41127733
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40425677
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40072690
69Gastric acid secretion_Homo sapiens_hsa049710.39149143
70Insulin secretion_Homo sapiens_hsa049110.39110657
71FoxO signaling pathway_Homo sapiens_hsa040680.37182713
72Amoebiasis_Homo sapiens_hsa051460.35366502
73Adherens junction_Homo sapiens_hsa045200.32098880
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31814785
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28634897
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28258718
77Amphetamine addiction_Homo sapiens_hsa050310.23845636
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23752278
79Fat digestion and absorption_Homo sapiens_hsa049750.23380082
80Regulation of autophagy_Homo sapiens_hsa041400.23284400
81Circadian entrainment_Homo sapiens_hsa047130.22469198
82Metabolic pathways_Homo sapiens_hsa011000.22054915
83Sulfur relay system_Homo sapiens_hsa041220.21949823
84Circadian rhythm_Homo sapiens_hsa047100.21400535
85Renal cell carcinoma_Homo sapiens_hsa052110.20560735
86Histidine metabolism_Homo sapiens_hsa003400.20013419
87Dorso-ventral axis formation_Homo sapiens_hsa043200.19919612
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18718336
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.18686548
90VEGF signaling pathway_Homo sapiens_hsa043700.18359987
91Melanogenesis_Homo sapiens_hsa049160.15900711
92Platelet activation_Homo sapiens_hsa046110.15596793
93Ovarian steroidogenesis_Homo sapiens_hsa049130.15550856
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.15549422
95Tyrosine metabolism_Homo sapiens_hsa003500.14937377
96GnRH signaling pathway_Homo sapiens_hsa049120.14888616
97Gap junction_Homo sapiens_hsa045400.14692949
98Proteoglycans in cancer_Homo sapiens_hsa052050.14462441
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14155649
100Pancreatic secretion_Homo sapiens_hsa049720.12629381
101Notch signaling pathway_Homo sapiens_hsa043300.12279156
102Bile secretion_Homo sapiens_hsa049760.11469191
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.09653438
104mTOR signaling pathway_Homo sapiens_hsa041500.09624218
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.08497236
106Long-term depression_Homo sapiens_hsa047300.08142780
107Cholinergic synapse_Homo sapiens_hsa047250.07269841
108Taste transduction_Homo sapiens_hsa047420.07163386
109Glycerolipid metabolism_Homo sapiens_hsa005610.07031833
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.06370716
111Purine metabolism_Homo sapiens_hsa002300.05528269
112Toxoplasmosis_Homo sapiens_hsa051450.04795672
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.04021021
114Estrogen signaling pathway_Homo sapiens_hsa049150.03248604
115Small cell lung cancer_Homo sapiens_hsa052220.01769547
116Salivary secretion_Homo sapiens_hsa049700.01456928
117MAPK signaling pathway_Homo sapiens_hsa040100.00405017

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