MB21D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of fever generation (GO:0031620)5.22890543
2regulation of vitamin D biosynthetic process (GO:0060556)4.84241521
3neuron cell-cell adhesion (GO:0007158)4.83075734
4proteasome assembly (GO:0043248)4.66754099
5positive regulation of heat generation (GO:0031652)4.56534601
6gonadal mesoderm development (GO:0007506)4.54577320
7protein localization to kinetochore (GO:0034501)4.49674256
8pyrimidine nucleobase catabolic process (GO:0006208)4.47556088
9regulation of chronic inflammatory response (GO:0002676)4.46844109
10locomotory exploration behavior (GO:0035641)4.38144756
11mitotic metaphase plate congression (GO:0007080)4.32306643
12vocalization behavior (GO:0071625)4.27901303
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.25329267
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.09146568
15protein localization to chromosome, centromeric region (GO:0071459)4.07001494
16neurotransmitter-gated ion channel clustering (GO:0072578)4.05101056
17glutamate secretion (GO:0014047)4.02897702
18regulation of mononuclear cell migration (GO:0071675)4.02053076
19regulation of cytokine secretion involved in immune response (GO:0002739)3.93841434
20dendritic spine morphogenesis (GO:0060997)3.93138697
21protein localization to synapse (GO:0035418)3.89267025
22synaptic vesicle exocytosis (GO:0016079)3.85706798
23branching involved in labyrinthine layer morphogenesis (GO:0060670)3.83734686
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.79574782
25regulation of glutamate receptor signaling pathway (GO:1900449)3.78892950
26nucleobase catabolic process (GO:0046113)3.73752755
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73547784
28establishment of integrated proviral latency (GO:0075713)3.71507262
29layer formation in cerebral cortex (GO:0021819)3.71439939
30presynaptic membrane assembly (GO:0097105)3.68679050
31establishment of viral latency (GO:0019043)3.63863662
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.60453362
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57460430
34regulation of DNA methylation (GO:0044030)3.56435984
35neuron recognition (GO:0008038)3.56422230
36regulation of heat generation (GO:0031650)3.53827805
37IMP biosynthetic process (GO:0006188)3.50084920
38regulation of vitamin metabolic process (GO:0030656)3.48362776
39postsynaptic membrane organization (GO:0001941)3.46664663
40exploration behavior (GO:0035640)3.46486508
41cerebellar granule cell differentiation (GO:0021707)3.45402530
42synaptic vesicle maturation (GO:0016188)3.45342398
43axonal fasciculation (GO:0007413)3.41900276
44gamma-aminobutyric acid transport (GO:0015812)3.41866098
45regulation of synaptic vesicle exocytosis (GO:2000300)3.41567098
46metaphase plate congression (GO:0051310)3.41417130
47neurotransmitter secretion (GO:0007269)3.39978047
48CENP-A containing nucleosome assembly (GO:0034080)3.39303458
49presynaptic membrane organization (GO:0097090)3.38236191
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38118712
51positive regulation of chemokine biosynthetic process (GO:0045080)3.26693535
52chromatin remodeling at centromere (GO:0031055)3.23571893
53IMP metabolic process (GO:0046040)3.22820771
54neuronal action potential propagation (GO:0019227)3.19579614
55cell migration in hindbrain (GO:0021535)3.19079584
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.14104179
57L-phenylalanine catabolic process (GO:0006559)3.14104179
58dendrite morphogenesis (GO:0048813)3.13592096
59establishment of chromosome localization (GO:0051303)3.12359760
60glutamate receptor signaling pathway (GO:0007215)3.07995414
61monocyte chemotaxis (GO:0002548)3.07712851
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05575625
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05042379
64regulation of NFAT protein import into nucleus (GO:0051532)3.03580916
65regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.02994836
66behavioral response to cocaine (GO:0048148)2.99307671
67regulation of podosome assembly (GO:0071801)2.98870866
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98798685
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97965540
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97609782
71regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97609782
72negative regulation of ligase activity (GO:0051352)2.96797463
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96797463
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.95727319
75auditory behavior (GO:0031223)2.95149033
76ribosome assembly (GO:0042255)2.94045962
77regulation of immunoglobulin secretion (GO:0051023)2.93680149
78cellular protein complex localization (GO:0034629)2.93507452
79synaptic transmission, glutamatergic (GO:0035249)2.93154982
80positive regulation of synapse maturation (GO:0090129)2.93042724
81folic acid-containing compound biosynthetic process (GO:0009396)2.92308548
82neuron-neuron synaptic transmission (GO:0007270)2.90865814
83cellular ketone body metabolic process (GO:0046950)2.90662962
84negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89727400
85negative regulation of mitotic sister chromatid separation (GO:2000816)2.89727400
86negative regulation of sister chromatid segregation (GO:0033046)2.89727400
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89727400
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89727400
89positive regulation of chromosome segregation (GO:0051984)2.89439409
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.88519730
91L-phenylalanine metabolic process (GO:0006558)2.88519730
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88464816
93somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.88243814
94somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.88243814
95isotype switching (GO:0045190)2.88243814
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88161161
97negative regulation of chromosome segregation (GO:0051985)2.88064760
98regulation of helicase activity (GO:0051095)2.87370694
99regulation of dendritic spine morphogenesis (GO:0061001)2.86764551
100positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.86399966
101cellular response to nicotine (GO:0071316)2.84121582
102spindle checkpoint (GO:0031577)2.83722916
103regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83153799
104regulation of synaptic vesicle transport (GO:1902803)2.81452462
105regulation of neuronal synaptic plasticity (GO:0048168)2.81191743
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.80939516
107protein complex localization (GO:0031503)2.80517213
108negative regulation of DNA-dependent DNA replication (GO:2000104)2.78604022
109long-term synaptic potentiation (GO:0060291)2.77594164
110sarcoplasmic reticulum calcium ion transport (GO:0070296)2.74478837
111folic acid transport (GO:0015884)2.74148573
112neurotransmitter transport (GO:0006836)2.73514524
113cellular response to nerve growth factor stimulus (GO:1990090)2.72629315
114response to nerve growth factor (GO:1990089)2.72629315
115glutamate metabolic process (GO:0006536)2.71857283
116positive regulation of synapse assembly (GO:0051965)2.70966201
117protein localization to chromosome (GO:0034502)2.70515715
118ganglion development (GO:0061548)2.67886730
119synapse organization (GO:0050808)2.66616804
120histone exchange (GO:0043486)2.65892303
121anterior/posterior axis specification, embryo (GO:0008595)2.65421413
122cellular response to arsenic-containing substance (GO:0071243)2.65404995
123synapse assembly (GO:0007416)2.65368249
124dendritic spine organization (GO:0097061)2.63792333
125regulation of chemokine biosynthetic process (GO:0045073)2.63699594
126mitotic spindle checkpoint (GO:0071174)2.63633958
127central nervous system projection neuron axonogenesis (GO:0021952)2.63527012
128regulation of T-helper 1 cell differentiation (GO:0045625)2.63427664
129gamma-aminobutyric acid signaling pathway (GO:0007214)2.62811816
130aromatic amino acid family catabolic process (GO:0009074)2.62277449
131dicarboxylic acid biosynthetic process (GO:0043650)2.62071255
132regulation of mitotic spindle checkpoint (GO:1903504)2.61068536
133regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61068536
134innervation (GO:0060384)2.60959398
135regulation of sister chromatid segregation (GO:0033045)2.60816671
136regulation of mitotic sister chromatid separation (GO:0010965)2.60816671
137regulation of mitotic sister chromatid segregation (GO:0033047)2.60816671
138positive regulation of membrane potential (GO:0045838)2.60593828
139regulation of chromosome segregation (GO:0051983)2.59414783
140eosinophil chemotaxis (GO:0048245)2.59041688
141DNA replication-dependent nucleosome organization (GO:0034723)2.58747198
142DNA replication-dependent nucleosome assembly (GO:0006335)2.58747198
143glyoxylate metabolic process (GO:0046487)2.58670656
144synaptic vesicle endocytosis (GO:0048488)2.57774243
145NIK/NF-kappaB signaling (GO:0038061)2.57313868
146natural killer cell mediated cytotoxicity (GO:0042267)2.56951185
147natural killer cell mediated immunity (GO:0002228)2.56951185
148response to histamine (GO:0034776)2.55558537
149neuromuscular process controlling balance (GO:0050885)2.55532137
150regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55418347
151regulation of neurotransmitter levels (GO:0001505)2.55152680
152negative regulation of sodium ion transport (GO:0010766)2.54966763
153positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54656958
154regulation of postsynaptic membrane potential (GO:0060078)2.54358709
155trophoblast giant cell differentiation (GO:0060707)2.53253881
156DNA replication-independent nucleosome organization (GO:0034724)2.52614765
157DNA replication-independent nucleosome assembly (GO:0006336)2.52614765
158inflammatory response to antigenic stimulus (GO:0002437)2.52025573
159DNA replication checkpoint (GO:0000076)2.51612819
160activation of protein kinase A activity (GO:0034199)2.51238398
161coenzyme catabolic process (GO:0009109)2.51108544
162proline transport (GO:0015824)2.50994486
163C4-dicarboxylate transport (GO:0015740)2.50689454
164transmission of nerve impulse (GO:0019226)2.50505912
165ketone body metabolic process (GO:1902224)2.50389601
166positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50173366
167regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48840495
168positive regulation of humoral immune response (GO:0002922)2.48576371
169mitotic spindle assembly checkpoint (GO:0007094)2.48570272
170mitotic chromosome condensation (GO:0007076)2.48004693
171regulation of synapse structural plasticity (GO:0051823)2.47269928
172DNA double-strand break processing (GO:0000729)2.47167477
173social behavior (GO:0035176)2.46995283
174intraspecies interaction between organisms (GO:0051703)2.46995283
175regulation of synaptic plasticity (GO:0048167)2.46768103
176bile acid biosynthetic process (GO:0006699)2.46249880
177spindle assembly checkpoint (GO:0071173)2.46024033
178purine nucleobase biosynthetic process (GO:0009113)2.45708222
179negative regulation of microtubule polymerization (GO:0031115)2.45345712
180mitotic G2/M transition checkpoint (GO:0044818)2.44984760
181cerebellar Purkinje cell differentiation (GO:0021702)2.44724179
182positive regulation of protein autophosphorylation (GO:0031954)2.43892229
183drug catabolic process (GO:0042737)2.43173972
184activation of MAPKKK activity (GO:0000185)2.41960531
185regulation of dendritic spine development (GO:0060998)2.41223714
186female gonad development (GO:0008585)2.40995975
187activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.39841340
188substrate-dependent cell migration (GO:0006929)2.39005018
189membrane hyperpolarization (GO:0060081)2.38696507
190axon extension (GO:0048675)2.38326824
191regulation of histone H3-K9 methylation (GO:0051570)2.38222657
192triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.37823720
193mating behavior (GO:0007617)2.35402923
194exogenous drug catabolic process (GO:0042738)2.34317212
195dicarboxylic acid catabolic process (GO:0043649)2.33368469
196prepulse inhibition (GO:0060134)2.32933671
197negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.32486727
198mechanosensory behavior (GO:0007638)2.32340540
199regulation of neurotransmitter secretion (GO:0046928)2.31526573
200kynurenine metabolic process (GO:0070189)2.29492015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.15583747
2EZH2_22144423_ChIP-Seq_EOC_Human4.44545390
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51110597
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25372991
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.18517895
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17602837
7GBX2_23144817_ChIP-Seq_PC3_Human3.13899598
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96404532
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.94544154
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.84843729
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.84843729
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.84843729
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.73972105
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70242199
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63514862
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58641381
17AR_21909140_ChIP-Seq_LNCAP_Human2.52227093
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46410942
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.46238063
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44710792
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41561120
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41561120
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.38710720
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29976085
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25784124
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.24120866
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18790073
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.17613937
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15376101
30POU5F1_16153702_ChIP-ChIP_HESCs_Human2.14844190
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07423093
32MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06142326
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05110968
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.04092340
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02788887
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02365890
37REST_21632747_ChIP-Seq_MESCs_Mouse2.01243592
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99663377
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97919752
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96207445
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95742088
42AR_21572438_ChIP-Seq_LNCaP_Human1.92585048
43TAF15_26573619_Chip-Seq_HEK293_Human1.91369650
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.91322770
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88414870
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87381830
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86847286
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.84352745
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.82911544
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82114805
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.80320275
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77500853
53ELK1_19687146_ChIP-ChIP_HELA_Human1.77024572
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76359879
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71853809
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.69986743
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.68988695
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.66518122
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65219494
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62649010
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61436201
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.58980080
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.58871322
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57574677
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56812990
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.56364677
67DROSHA_22980978_ChIP-Seq_HELA_Human1.56065401
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52971316
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52490888
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50253979
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49546737
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47391320
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47225401
74NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.45400443
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44898351
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.44302114
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.44075711
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.42869627
79SMAD4_21799915_ChIP-Seq_A2780_Human1.42694068
80DCP1A_22483619_ChIP-Seq_HELA_Human1.42408450
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.41466674
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40239259
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.39701306
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37472759
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35822574
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33316333
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.33268259
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32993373
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32680425
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.32323547
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32019344
92* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31426950
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31332600
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31121767
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30612441
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.30124188
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29964653
98TFEB_21752829_ChIP-Seq_HELA_Human1.29891756
99* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29491568
100P300_19829295_ChIP-Seq_ESCs_Human1.28677590
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.28260901
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.26532955
103FUS_26573619_Chip-Seq_HEK293_Human1.26102035
104ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25847078
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25631424
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.24892445
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23521041
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23047712
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.21499255
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21182953
111ZNF274_21170338_ChIP-Seq_K562_Hela1.20480786
112RXR_22158963_ChIP-Seq_LIVER_Mouse1.20440146
113* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20419270
114AHR_22903824_ChIP-Seq_MCF-7_Human1.19819847
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18895044
116TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17998490
117NANOG_18692474_ChIP-Seq_MEFs_Mouse1.17677522
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17335197
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17222659
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16421999
121RNF2_27304074_Chip-Seq_NSC_Mouse1.15623465
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14829759
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.14015202
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12717445
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12261799
126THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10725923
127EP300_21415370_ChIP-Seq_HL-1_Mouse1.10581318
128EWS_26573619_Chip-Seq_HEK293_Human1.09823261
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09279388
130TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09138076
131TP53_18474530_ChIP-ChIP_U2OS_Human1.08884116
132SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06912027
133SALL1_21062744_ChIP-ChIP_HESCs_Human1.06173818
134STAT3_23295773_ChIP-Seq_U87_Human1.06145760
135ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05166695
136RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05163623
137AR_19668381_ChIP-Seq_PC3_Human1.05154747
138Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04832403
139CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04280513
140AR_25329375_ChIP-Seq_VCAP_Human1.03927097
141ELF5_23300383_ChIP-Seq_T47D_Human1.03225543
142JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03030699
143EGR1_19374776_ChIP-ChIP_THP-1_Human1.02897436
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02865355
145FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02664326
146HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01923861
147RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01771450
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01529106
149WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00878401
150MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00813053
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00725888
152ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00461317
153VDR_22108803_ChIP-Seq_LS180_Human1.00266223
154NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00244358
155TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99435259
156FLI1_27457419_Chip-Seq_LIVER_Mouse0.99384554
157LXR_22158963_ChIP-Seq_LIVER_Mouse0.98899309
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98488468
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98488468
160MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98179745
161CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97519684
162TP53_20018659_ChIP-ChIP_R1E_Mouse0.97409447
163BCAT_22108803_ChIP-Seq_LS180_Human0.97143756
164STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96842155
165ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96707326
166SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96667569
167HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95419277
168WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95162270
169SMAD4_21741376_ChIP-Seq_HESCs_Human0.94874178
170STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94752040
171NANOG_16518401_ChIP-PET_MESCs_Mouse0.94403823
172YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94388872
173SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93132195
174PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93049048
175ETS1_20019798_ChIP-Seq_JURKAT_Human0.92013711
176POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91997557
177REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91721759
178UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91605890
179MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91446744
180CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90197095
181P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87054171
182TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86561584
183RUNX2_22187159_ChIP-Seq_PCA_Human0.86509738
184TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86223618
185NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84928238
186TCF4_23295773_ChIP-Seq_U87_Human0.84535136
187SMAD4_21741376_ChIP-Seq_EPCs_Human0.84369245
188KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82592049
189SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82542966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.86814513
2MP0003880_abnormal_central_pattern3.75522220
3MP0003303_peritoneal_inflammation3.51353160
4MP0003693_abnormal_embryo_hatching3.33983461
5MP0004270_analgesia3.11057238
6MP0003718_maternal_effect3.10050285
7MP0003635_abnormal_synaptic_transmissio2.94260560
8MP0010307_abnormal_tumor_latency2.81155314
9MP0002254_reproductive_system_inflammat2.75129119
10MP0010352_gastrointestinal_tract_polyps2.64490228
11MP0005360_urolithiasis2.59589722
12MP0002139_abnormal_hepatobiliary_system2.56683885
13MP0001984_abnormal_olfaction2.50467960
14MP0002063_abnormal_learning/memory/cond2.42476226
15MP0004957_abnormal_blastocyst_morpholog2.36563548
16MP0009745_abnormal_behavioral_response2.32636626
17MP0003111_abnormal_nucleus_morphology2.27165947
18MP0005423_abnormal_somatic_nervous2.25855125
19MP0002064_seizures2.22505186
20MP0001968_abnormal_touch/_nociception2.21804159
21MP0000778_abnormal_nervous_system2.18004890
22MP0004510_myositis2.14683801
23MP0005085_abnormal_gallbladder_physiolo2.13287784
24MP0004858_abnormal_nervous_system2.12232787
25MP0002572_abnormal_emotion/affect_behav2.09242523
26MP0002734_abnormal_mechanical_nocicepti2.09061101
27MP0006082_CNS_inflammation2.04746461
28MP0002751_abnormal_autonomic_nervous2.01488832
29MP0003329_amyloid_beta_deposits2.01481106
30MP0002148_abnormal_hypersensitivity_rea1.98737209
31MP0009046_muscle_twitch1.97927880
32MP0008875_abnormal_xenobiotic_pharmacok1.97657510
33MP0001486_abnormal_startle_reflex1.93016072
34MP0003077_abnormal_cell_cycle1.88954035
35MP0008932_abnormal_embryonic_tissue1.87444336
36MP0001188_hyperpigmentation1.85762589
37MP0003448_altered_tumor_morphology1.84885795
38MP0002272_abnormal_nervous_system1.82042377
39MP0010094_abnormal_chromosome_stability1.81512710
40MP0002736_abnormal_nociception_after1.80095487
41MP0003950_abnormal_plasma_membrane1.76585669
42MP0008057_abnormal_DNA_replication1.76048975
43MP0005365_abnormal_bile_salt1.74571187
44MP0003453_abnormal_keratinocyte_physiol1.73671060
45MP0002184_abnormal_innervation1.69800619
46MP0001440_abnormal_grooming_behavior1.69730415
47MP0001730_embryonic_growth_arrest1.68815861
48MP0009840_abnormal_foam_cell1.62848380
49MP0005076_abnormal_cell_differentiation1.62130814
50MP0005187_abnormal_penis_morphology1.58082239
51MP0002067_abnormal_sensory_capabilities1.56761207
52MP0004885_abnormal_endolymph1.56059048
53MP0010030_abnormal_orbit_morphology1.53603943
54MP0001542_abnormal_bone_strength1.52516842
55MP0002557_abnormal_social/conspecific_i1.51403190
56MP0001293_anophthalmia1.50380304
57MP0006054_spinal_hemorrhage1.45057370
58MP0006276_abnormal_autonomic_nervous1.43987059
59MP0002733_abnormal_thermal_nociception1.43651385
60MP0003787_abnormal_imprinting1.43222944
61MP0000955_abnormal_spinal_cord1.41534727
62MP0005257_abnormal_intraocular_pressure1.40359931
63MP0009785_altered_susceptibility_to1.40064463
64MP0010234_abnormal_vibrissa_follicle1.38389728
65MP0001727_abnormal_embryo_implantation1.37384936
66MP0008438_abnormal_cutaneous_collagen1.33034890
67MP0000350_abnormal_cell_proliferation1.32726501
68MP0008007_abnormal_cellular_replicative1.31473671
69MP0004924_abnormal_behavior1.30019763
70MP0005386_behavior/neurological_phenoty1.30019763
71MP0001853_heart_inflammation1.29369944
72MP0002090_abnormal_vision1.29042090
73MP0002735_abnormal_chemical_nociception1.28313640
74MP0002332_abnormal_exercise_endurance1.26992565
75MP0008877_abnormal_DNA_methylation1.25771906
76MP0002882_abnormal_neuron_morphology1.24477697
77MP0003091_abnormal_cell_migration1.24375752
78MP0002822_catalepsy1.24315712
79MP0001970_abnormal_pain_threshold1.24062092
80MP0008058_abnormal_DNA_repair1.23679278
81MP0005499_abnormal_olfactory_system1.22303631
82MP0005394_taste/olfaction_phenotype1.22303631
83MP0005395_other_phenotype1.20519962
84MP0001485_abnormal_pinna_reflex1.20034314
85MP0004811_abnormal_neuron_physiology1.19971094
86MP0003221_abnormal_cardiomyocyte_apopto1.16116397
87MP0009780_abnormal_chondrocyte_physiolo1.13622166
88MP0008004_abnormal_stomach_pH1.12864933
89MP0001919_abnormal_reproductive_system1.12654720
90MP0002066_abnormal_motor_capabilities/c1.12280059
91MP0002152_abnormal_brain_morphology1.12262300
92MP0001501_abnormal_sleep_pattern1.09951614
93MP0000751_myopathy1.09339352
94MP0001529_abnormal_vocalization1.09033855
95MP0010329_abnormal_lipoprotein_level1.08829333
96MP0002653_abnormal_ependyma_morphology1.07895098
97MP0000343_altered_response_to1.07377863
98MP0005058_abnormal_lysosome_morphology1.06938132
99MP0003122_maternal_imprinting1.05755941
100MP0009764_decreased_sensitivity_to1.03715673
101MP0008789_abnormal_olfactory_epithelium1.03369776
102MP0005197_abnormal_uvea_morphology1.03316418
103MP0003879_abnormal_hair_cell1.02570563
104MP0004145_abnormal_muscle_electrophysio1.01830198
105MP0002697_abnormal_eye_size1.01416832
106MP0003632_abnormal_nervous_system1.01378973
107MP0002085_abnormal_embryonic_tissue1.01170964
108MP0004742_abnormal_vestibular_system1.00733904
109MP0003252_abnormal_bile_duct0.98925496
110MP0001672_abnormal_embryogenesis/_devel0.98269276
111MP0005380_embryogenesis_phenotype0.98269276
112MP0003705_abnormal_hypodermis_morpholog0.96519648
113MP0005671_abnormal_response_to0.92807478
114MP0000534_abnormal_ureter_morphology0.92187450
115MP0002752_abnormal_somatic_nervous0.91825364
116MP0003861_abnormal_nervous_system0.90823866
117MP0004142_abnormal_muscle_tone0.90678332
118MP0002837_dystrophic_cardiac_calcinosis0.90188836
119MP0005310_abnormal_salivary_gland0.89047931
120MP0000604_amyloidosis0.88757473
121MP0001243_abnormal_dermal_layer0.88676271
122MP0009765_abnormal_xenobiotic_induced0.87966622
123MP0008569_lethality_at_weaning0.87183419
124MP0003631_nervous_system_phenotype0.87103035
125MP0005551_abnormal_eye_electrophysiolog0.86664286
126MP0009697_abnormal_copulation0.86645462
127MP0000579_abnormal_nail_morphology0.86551308
128MP0002084_abnormal_developmental_patter0.85729470
129MP0002909_abnormal_adrenal_gland0.85274217
130MP0000537_abnormal_urethra_morphology0.84992395
131MP0001963_abnormal_hearing_physiology0.84197018
132MP0005645_abnormal_hypothalamus_physiol0.84173934
133MP0005646_abnormal_pituitary_gland0.83745502
134MP0002233_abnormal_nose_morphology0.83239287
135MP0003699_abnormal_female_reproductive0.82959214
136MP0001502_abnormal_circadian_rhythm0.82691567
137MP0001216_abnormal_epidermal_layer0.81961698
138MP0005623_abnormal_meninges_morphology0.81915578
139MP0004947_skin_inflammation0.81388363
140MP0005508_abnormal_skeleton_morphology0.80739659
141MP0003633_abnormal_nervous_system0.78861327
142MP0002877_abnormal_melanocyte_morpholog0.78587032
143MP0003567_abnormal_fetal_cardiomyocyte0.78557645
144MP0002069_abnormal_eating/drinking_beha0.77862386
145MP0003300_gastrointestinal_ulcer0.77344315
146MP0000631_abnormal_neuroendocrine_gland0.76927623
147MP0001191_abnormal_skin_condition0.76620621
148MP0001697_abnormal_embryo_size0.76189366
149MP0003195_calcinosis0.75424386
150MP0000569_abnormal_digit_pigmentation0.74924567
151MP0003806_abnormal_nucleotide_metabolis0.74866826
152MP0002092_abnormal_eye_morphology0.74636287
153MP0003634_abnormal_glial_cell0.74154465
154MP0000733_abnormal_muscle_development0.73592732
155MP0001177_atelectasis0.72778306
156MP0000358_abnormal_cell_content/0.72019922
157MP0000026_abnormal_inner_ear0.72019758
158MP0009384_cardiac_valve_regurgitation0.71346145
159MP0000490_abnormal_crypts_of0.71203184
160MP0005023_abnormal_wound_healing0.70953561
161MP0002229_neurodegeneration0.70646963
162MP0000627_abnormal_mammary_gland0.70305684
163MP0003119_abnormal_digestive_system0.70058326
164MP0003942_abnormal_urinary_system0.69818275
165MP0002080_prenatal_lethality0.69805442
166MP0003941_abnormal_skin_development0.68850913
167MP0000313_abnormal_cell_death0.68677105
168MP0009672_abnormal_birth_weight0.68438128
169MP0004019_abnormal_vitamin_homeostasis0.67765504
170MP0002249_abnormal_larynx_morphology0.67459426
171MP0003868_abnormal_feces_composition0.67332319
172MP0003385_abnormal_body_wall0.66791578
173MP0003890_abnormal_embryonic-extraembry0.66483916
174MP0005332_abnormal_amino_acid0.66306530
175MP0001666_abnormal_nutrient_absorption0.65715719
176MP0001905_abnormal_dopamine_level0.65193204
177MP0005647_abnormal_sex_gland0.65016523
178MP0005621_abnormal_cell_physiology0.64606805
179MP0000371_diluted_coat_color0.64469998
180MP0002796_impaired_skin_barrier0.61992306
181MP0004085_abnormal_heartbeat0.61879903
182MP0001299_abnormal_eye_distance/0.61149265

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.73015280
2Disinhibition (HP:0000734)4.56716638
3Myokymia (HP:0002411)4.09210897
4Hyperventilation (HP:0002883)3.99127795
5Abnormality of liposaccharide metabolism (HP:0010968)3.84227813
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.84227813
7Abnormality of glycolipid metabolism (HP:0010969)3.84227813
8Agnosia (HP:0010524)3.83816585
9Focal seizures (HP:0007359)3.79640300
10Apathy (HP:0000741)3.71986042
11Atonic seizures (HP:0010819)3.64754255
12Abnormality of the corticospinal tract (HP:0002492)3.35853094
13Insidious onset (HP:0003587)3.29985714
14Termporal pattern (HP:0011008)3.29985714
15Inappropriate behavior (HP:0000719)3.29689545
16Diminished motivation (HP:0000745)3.29302691
17Epileptic encephalopathy (HP:0200134)3.24387909
18Deep venous thrombosis (HP:0002625)3.19724704
19Absence seizures (HP:0002121)3.15548048
20IgA deficiency (HP:0002720)3.12690421
21Visual hallucinations (HP:0002367)3.11832057
22Adactyly (HP:0009776)3.06076586
23Septo-optic dysplasia (HP:0100842)3.00756034
24Vacuolated lymphocytes (HP:0001922)3.00606729
25Nuclear cataract (HP:0100018)2.97158707
26Generalized tonic-clonic seizures (HP:0002069)2.94995901
27Spastic diplegia (HP:0001264)2.90211127
28Hypobetalipoproteinemia (HP:0003563)2.86873649
29Shoulder girdle muscle weakness (HP:0003547)2.80460819
30Abnormality of the septum pellucidum (HP:0007375)2.74550342
31Cerebral inclusion bodies (HP:0100314)2.72906726
32Dialeptic seizures (HP:0011146)2.72386951
33Febrile seizures (HP:0002373)2.71556664
34Absent septum pellucidum (HP:0001331)2.69993363
35Broad-based gait (HP:0002136)2.69363744
36Loss of speech (HP:0002371)2.67654893
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.65847181
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.65847181
39Impaired vibration sensation in the lower limbs (HP:0002166)2.65134146
40Abnormality of the lower motor neuron (HP:0002366)2.64309596
41Drooling (HP:0002307)2.61968361
42Excessive salivation (HP:0003781)2.61968361
43Intrahepatic cholestasis (HP:0001406)2.61931467
44Multiple enchondromatosis (HP:0005701)2.61653400
45Amblyopia (HP:0000646)2.55174274
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50722849
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.50531666
48Embryonal renal neoplasm (HP:0011794)2.50124340
49Rhabdomyosarcoma (HP:0002859)2.49186546
50Progressive cerebellar ataxia (HP:0002073)2.48809787
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.48796731
52Meningioma (HP:0002858)2.48389948
53Parakeratosis (HP:0001036)2.45781529
54Neurofibrillary tangles (HP:0002185)2.45550289
55Abnormal trabecular bone morphology (HP:0100671)2.41746801
56Dysdiadochokinesis (HP:0002075)2.41231049
57Glioma (HP:0009733)2.40456792
58Abnormality of chromosome stability (HP:0003220)2.40306385
59Status epilepticus (HP:0002133)2.33370867
60Xanthomatosis (HP:0000991)2.32392582
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.32349753
62Nephroblastoma (Wilms tumor) (HP:0002667)2.30554398
63Hyperlipoproteinemia (HP:0010980)2.28819207
64Morphological abnormality of the pyramidal tract (HP:0002062)2.28172821
65Action tremor (HP:0002345)2.27776226
66Deep philtrum (HP:0002002)2.20868330
67Urinary bladder sphincter dysfunction (HP:0002839)2.20613876
68Abnormality of the musculature of the pelvis (HP:0001469)2.20293910
69Abnormality of the hip-girdle musculature (HP:0001445)2.20293910
70Posterior subcapsular cataract (HP:0007787)2.19174012
71Abdominal situs inversus (HP:0003363)2.18993941
72Abnormality of abdominal situs (HP:0011620)2.18993941
73Fused cervical vertebrae (HP:0002949)2.18591942
74Polyphagia (HP:0002591)2.17473955
75Curly hair (HP:0002212)2.15426751
76Abnormal lung lobation (HP:0002101)2.15425000
77Chromsome breakage (HP:0040012)2.15183863
78Ankle contracture (HP:0006466)2.14537164
79Epileptiform EEG discharges (HP:0011182)2.14515921
80Skull defect (HP:0001362)2.14448977
81Porencephaly (HP:0002132)2.11168817
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10515102
83Generalized myoclonic seizures (HP:0002123)2.09146306
84Leiomyosarcoma (HP:0100243)2.08825482
85Uterine leiomyosarcoma (HP:0002891)2.08825482
86Hemiparesis (HP:0001269)2.08446136
87Abnormal eating behavior (HP:0100738)2.07383290
88Abnormal gallbladder physiology (HP:0012438)2.07374903
89Cholecystitis (HP:0001082)2.07374903
90EEG with generalized epileptiform discharges (HP:0011198)2.07165542
91Spastic gait (HP:0002064)2.06825149
92Poor eye contact (HP:0000817)2.06282169
93Gaze-evoked nystagmus (HP:0000640)2.05263364
94Agitation (HP:0000713)2.05173515
95Medulloblastoma (HP:0002885)2.04805650
96Hypolipoproteinemia (HP:0010981)2.04470243
97Torticollis (HP:0000473)2.04095319
98Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03500139
99Metaphyseal irregularity (HP:0003025)2.03338175
100Ankle clonus (HP:0011448)2.02703154
101Impaired social interactions (HP:0000735)2.01333741
102Abnormal social behavior (HP:0012433)2.01333741
103Rough bone trabeculation (HP:0100670)2.01070408
104Carpal bone hypoplasia (HP:0001498)2.00790473
105Pelvic girdle muscle weakness (HP:0003749)2.00580007
106Urinary urgency (HP:0000012)2.00040036
107Hypsarrhythmia (HP:0002521)1.99825141
108Abnormality of methionine metabolism (HP:0010901)1.99023041
109Oral leukoplakia (HP:0002745)1.96049570
110Colon cancer (HP:0003003)1.96028571
111Abnormality of the labia minora (HP:0012880)1.95378008
112Nausea (HP:0002018)1.95369527
113Congenital ichthyosiform erythroderma (HP:0007431)1.91566340
114Esophageal varix (HP:0002040)1.91281219
115Impaired vibratory sensation (HP:0002495)1.90430427
116Sensory axonal neuropathy (HP:0003390)1.90001811
117Depression (HP:0000716)1.88570193
118Hyperglycinemia (HP:0002154)1.86943810
119Blue irides (HP:0000635)1.86355250
120Myelomeningocele (HP:0002475)1.83621423
121Bladder neoplasm (HP:0009725)1.83370478
122Bladder carcinoma (HP:0002862)1.83370478
123Lower limb muscle weakness (HP:0007340)1.83035374
124Dysmetria (HP:0001310)1.82197292
125Fetal akinesia sequence (HP:0001989)1.81464496
126Ependymoma (HP:0002888)1.81213512
127Abnormality of the astrocytes (HP:0100707)1.80826896
128Astrocytoma (HP:0009592)1.80826896
129Supranuclear gaze palsy (HP:0000605)1.80794859
130Ketosis (HP:0001946)1.80273755
131Ketoacidosis (HP:0001993)1.79706870
132Dysmetric saccades (HP:0000641)1.79528950
133Inability to walk (HP:0002540)1.79476192
134Anxiety (HP:0000739)1.78372012
135Tetraparesis (HP:0002273)1.78182850
136Amyotrophic lateral sclerosis (HP:0007354)1.77739780
137Progressive sensorineural hearing impairment (HP:0000408)1.77475157
138Focal dystonia (HP:0004373)1.76950880
139Birth length less than 3rd percentile (HP:0003561)1.76723205
140Pheochromocytoma (HP:0002666)1.76436330
141Limb dystonia (HP:0002451)1.76147029
142Bronchomalacia (HP:0002780)1.75783736
143Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.75570854
144Progressive inability to walk (HP:0002505)1.74898801
145Mutism (HP:0002300)1.73877225
146Aplasia involving bones of the extremities (HP:0009825)1.73403923
147Aplasia involving bones of the upper limbs (HP:0009823)1.73403923
148Aplasia of the phalanges of the hand (HP:0009802)1.73403923
149Lower limb asymmetry (HP:0100559)1.73189289
150Transitional cell carcinoma of the bladder (HP:0006740)1.72828992
151Gastrointestinal carcinoma (HP:0002672)1.72765168
152Malignant gastrointestinal tract tumors (HP:0006749)1.72765168
153Epidermoid cyst (HP:0200040)1.72728259
154Benign neoplasm of the central nervous system (HP:0100835)1.72705691
155Abnormality of the Achilles tendon (HP:0005109)1.72699809
156Truncal ataxia (HP:0002078)1.72681707
157Long nose (HP:0003189)1.72047831
158Scanning speech (HP:0002168)1.71342361
159Craniofacial dystonia (HP:0012179)1.71341568
160Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.71326617
161Megalencephaly (HP:0001355)1.71294722
162Intention tremor (HP:0002080)1.71203798
163Prolonged partial thromboplastin time (HP:0003645)1.70688392
164Absent speech (HP:0001344)1.70675138
165Bifid tongue (HP:0010297)1.70605366
166Secondary amenorrhea (HP:0000869)1.67652613
167Deviation of the thumb (HP:0009603)1.67459842
168Hypoalphalipoproteinemia (HP:0003233)1.66774679
169Thoracolumbar scoliosis (HP:0002944)1.65830736
170Paraplegia (HP:0010550)1.65801005
171Supernumerary spleens (HP:0009799)1.65783157
172Progressive external ophthalmoplegia (HP:0000590)1.65323920
173Hyperthyroidism (HP:0000836)1.65149304
174Megaloblastic anemia (HP:0001889)1.65015719
175Abnormality of placental membranes (HP:0011409)1.64826927
176Amniotic constriction ring (HP:0009775)1.64826927
177Genetic anticipation (HP:0003743)1.64601892
178Postural tremor (HP:0002174)1.64260244
179Cortical dysplasia (HP:0002539)1.62684201
180Progressive neurologic deterioration (HP:0002344)1.62293385
181Hemiplegia (HP:0002301)1.62223528
182Spontaneous abortion (HP:0005268)1.61360245
183Hypoplastic nipples (HP:0002557)1.60828322
184Abnormality of glycolysis (HP:0004366)1.60820814
185Meckel diverticulum (HP:0002245)1.59632247
186Abnormality of aspartate family amino acid metabolism (HP:0010899)1.59504993
187Horseshoe kidney (HP:0000085)1.57467819
188Subcapsular cataract (HP:0000523)1.56599372
189Poor head control (HP:0002421)1.56512240
190Uterine neoplasm (HP:0010784)1.56020410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.97334945
2CASK3.75461966
3EPHA43.59711537
4TRIM282.87672816
5DAPK22.83614715
6MAP3K92.82858154
7IRAK32.82636895
8NTRK32.80505616
9MAP3K42.70704086
10NME22.62944151
11TSSK62.57197161
12EIF2AK32.57061480
13TTK2.51563473
14BUB12.49917840
15MST42.20878110
16ZAK2.14232171
17ERBB32.09391194
18TYRO32.07875005
19NTRK22.07787237
20MATK2.07588383
21MAP2K42.03488090
22MINK11.98302874
23CDC71.95240540
24KSR21.92116720
25LATS21.89855041
26MKNK21.87984593
27ACVR1B1.87273149
28PAK61.85469904
29MAPK131.85182281
30GRK71.85072763
31MAP2K71.77086529
32SRPK11.72485326
33STK241.71217568
34DYRK31.58583411
35PLK21.58260727
36KSR11.53862499
37PBK1.51536963
38PNCK1.51184809
39PHKG11.50281554
40PHKG21.50281554
41PLK31.49108810
42MOS1.40983438
43MAP3K141.40212772
44MAP3K21.39259455
45OXSR11.39161565
46PRKD31.34597292
47CLK11.32579469
48TAOK21.32313089
49PLK11.31353666
50PAK31.30311198
51MKNK11.29971243
52BMPR1B1.29926041
53NTRK11.28958399
54CDK191.28559444
55BMPR21.21614459
56PAK41.20080126
57FGFR21.19323474
58CDK51.13896795
59GRK51.07432123
60PLK41.07285295
61PRKCG1.06374295
62CSNK1G21.05934455
63ERBB41.04650460
64DYRK21.04527671
65WNK31.01783618
66EIF2AK20.99909946
67UHMK10.99893871
68DAPK10.97950206
69CAMK2A0.97727366
70MAP3K120.96947655
71CDK90.94753567
72SGK4940.93282459
73SGK2230.93282459
74PIM20.92362056
75CDK150.91044783
76CHUK0.89682223
77CDK180.89501442
78CDK140.89039969
79RET0.88945770
80TESK10.88922135
81CAMKK10.88470625
82STK390.87409746
83STK110.85358853
84TGFBR10.84507535
85TNIK0.84345064
86AURKA0.84145694
87TAF10.83611656
88VRK10.83429977
89DYRK1A0.79623480
90IKBKB0.79149740
91BRAF0.78080554
92CDK11A0.78039778
93SIK20.77213572
94CAMK2B0.76056831
95STK100.73392485
96SIK30.72194416
97FER0.71520608
98STK160.71010649
99CSNK1G30.70414530
100ALK0.68148797
101PDGFRA0.66294084
102MST1R0.66174753
103CSNK1G10.64933051
104DDR20.64451694
105ABL20.64116472
106TBK10.64035271
107WEE10.64033674
108EPHB20.63861874
109MET0.63442297
110WNK40.63148276
111PRKCZ0.63007916
112MAP3K80.62655756
113NME10.62300816
114MAP2K10.62007900
115ICK0.61610061
116ROCK10.61407467
117BCR0.61295000
118PKN10.60581993
119CHEK20.59866997
120PRPF4B0.59401740
121ADRBK10.58935136
122CSNK1A1L0.58883268
123FRK0.58741507
124MAP3K60.57702924
125FGR0.57578244
126MAP3K50.57529868
127IRAK20.56275866
128STK380.56144423
129ROCK20.55473143
130DMPK0.54053005
131NEK90.53826045
132MELK0.52811152
133ADRBK20.52536452
134CAMK2G0.51859092
135NEK10.50708403
136SGK20.50669695
137CCNB10.50520011
138CAMK2D0.49665670
139IKBKE0.49506692
140PTK2B0.49499239
141RIPK10.48887645
142LATS10.47859419
143LMTK20.47732076
144LIMK10.46565845
145ARAF0.45843316
146AURKB0.45677676
147PRKCI0.45357330
148NUAK10.45296898
149PRKCE0.44988989
150RAF10.43805392
151SGK10.43396115
152PIM10.42717676
153MAPK120.41201851
154CSNK1E0.40752610
155TAOK10.40450371
156RPS6KA40.40238240
157RPS6KA30.39029428
158PRKAA10.38265809
159DAPK30.37673686
160PAK10.37253934
161AKT30.36939570
162MAP3K130.36152205
163CHEK10.36045940
164BRSK20.34088356

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.86387844
2Nicotine addiction_Homo sapiens_hsa050332.66793502
3Nitrogen metabolism_Homo sapiens_hsa009102.62188366
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49531702
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43374124
6Cell cycle_Homo sapiens_hsa041102.38403433
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.22789786
8Synaptic vesicle cycle_Homo sapiens_hsa047212.17768694
9Rheumatoid arthritis_Homo sapiens_hsa053232.17360670
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13381946
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.13111517
12Arginine biosynthesis_Homo sapiens_hsa002202.03317243
13Mismatch repair_Homo sapiens_hsa034302.01932141
14GABAergic synapse_Homo sapiens_hsa047271.97259735
15Glutamatergic synapse_Homo sapiens_hsa047241.91529965
16Olfactory transduction_Homo sapiens_hsa047401.90267825
17Butanoate metabolism_Homo sapiens_hsa006501.89038337
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.88291090
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87308540
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86053266
21DNA replication_Homo sapiens_hsa030301.85748339
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83837473
23Basal transcription factors_Homo sapiens_hsa030221.82357414
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.78046936
25Legionellosis_Homo sapiens_hsa051341.76409316
26Long-term potentiation_Homo sapiens_hsa047201.73050710
27Circadian entrainment_Homo sapiens_hsa047131.70187811
28TNF signaling pathway_Homo sapiens_hsa046681.69458996
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68096218
30p53 signaling pathway_Homo sapiens_hsa041151.67038737
31Salmonella infection_Homo sapiens_hsa051321.66686776
32Protein export_Homo sapiens_hsa030601.66595960
33RNA transport_Homo sapiens_hsa030131.66451676
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63979230
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60518366
36Amphetamine addiction_Homo sapiens_hsa050311.58119513
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55666193
38Dopaminergic synapse_Homo sapiens_hsa047281.51714276
39Morphine addiction_Homo sapiens_hsa050321.49636498
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49494502
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48955277
42RNA degradation_Homo sapiens_hsa030181.42251244
43Bile secretion_Homo sapiens_hsa049761.42212458
44Taste transduction_Homo sapiens_hsa047421.42155747
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39863593
46Non-homologous end-joining_Homo sapiens_hsa034501.35811489
47Epstein-Barr virus infection_Homo sapiens_hsa051691.35591404
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33602197
49Axon guidance_Homo sapiens_hsa043601.31708462
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30065611
51Bladder cancer_Homo sapiens_hsa052191.29364958
52Salivary secretion_Homo sapiens_hsa049701.27983285
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27496097
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27349533
55Long-term depression_Homo sapiens_hsa047301.25481065
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24604509
57Selenocompound metabolism_Homo sapiens_hsa004501.24135479
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23925261
59Cholinergic synapse_Homo sapiens_hsa047251.23108222
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23009508
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22822142
62Serotonergic synapse_Homo sapiens_hsa047261.21288189
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20377813
64Insulin secretion_Homo sapiens_hsa049111.18172445
65Gap junction_Homo sapiens_hsa045401.17880983
66Lysosome_Homo sapiens_hsa041421.17479970
67Renin secretion_Homo sapiens_hsa049241.16258620
68Tryptophan metabolism_Homo sapiens_hsa003801.15106300
69TGF-beta signaling pathway_Homo sapiens_hsa043501.13244158
70Shigellosis_Homo sapiens_hsa051311.13212602
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11930389
72Spliceosome_Homo sapiens_hsa030401.11711373
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10070634
74Gastric acid secretion_Homo sapiens_hsa049711.09127492
75Influenza A_Homo sapiens_hsa051641.08766086
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07973808
77African trypanosomiasis_Homo sapiens_hsa051431.06644998
78RNA polymerase_Homo sapiens_hsa030201.05549460
79Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05358662
80mRNA surveillance pathway_Homo sapiens_hsa030151.05240443
81Oxytocin signaling pathway_Homo sapiens_hsa049211.04795759
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03892247
83Collecting duct acid secretion_Homo sapiens_hsa049661.02466124
84Cocaine addiction_Homo sapiens_hsa050301.01536749
85GnRH signaling pathway_Homo sapiens_hsa049121.00532834
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00518248
87Fatty acid degradation_Homo sapiens_hsa000711.00399611
88Folate biosynthesis_Homo sapiens_hsa007901.00202977
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99987291
90Fatty acid metabolism_Homo sapiens_hsa012120.99882072
91Thyroid cancer_Homo sapiens_hsa052160.99643062
92Apoptosis_Homo sapiens_hsa042100.98618280
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97452917
94Malaria_Homo sapiens_hsa051440.95526974
95Herpes simplex infection_Homo sapiens_hsa051680.92356648
96Adherens junction_Homo sapiens_hsa045200.91875753
97Allograft rejection_Homo sapiens_hsa053300.90970320
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86958284
99Asthma_Homo sapiens_hsa053100.86748963
100Complement and coagulation cascades_Homo sapiens_hsa046100.86119694
101Steroid biosynthesis_Homo sapiens_hsa001000.86029734
102PPAR signaling pathway_Homo sapiens_hsa033200.85615407
103MicroRNAs in cancer_Homo sapiens_hsa052060.85546167
104Systemic lupus erythematosus_Homo sapiens_hsa053220.85173097
105Phenylalanine metabolism_Homo sapiens_hsa003600.85144027
106Pyruvate metabolism_Homo sapiens_hsa006200.85039593
107Melanogenesis_Homo sapiens_hsa049160.83249241
108Sphingolipid metabolism_Homo sapiens_hsa006000.83099922
109Hepatitis B_Homo sapiens_hsa051610.83090171
110Estrogen signaling pathway_Homo sapiens_hsa049150.82913151
111Hepatitis C_Homo sapiens_hsa051600.82637899
112Pertussis_Homo sapiens_hsa051330.80535102
113Cardiac muscle contraction_Homo sapiens_hsa042600.79110772
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.78841930
115Homologous recombination_Homo sapiens_hsa034400.78608504
116Viral carcinogenesis_Homo sapiens_hsa052030.78564471
117Nucleotide excision repair_Homo sapiens_hsa034200.78244678
118Propanoate metabolism_Homo sapiens_hsa006400.77376113
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77324492
120Calcium signaling pathway_Homo sapiens_hsa040200.76398830
121Viral myocarditis_Homo sapiens_hsa054160.76220421
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76150481
123Glioma_Homo sapiens_hsa052140.75447634
124Prion diseases_Homo sapiens_hsa050200.75118923
125Vitamin B6 metabolism_Homo sapiens_hsa007500.75006430
126Hippo signaling pathway_Homo sapiens_hsa043900.74970925
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72358337
128Vitamin digestion and absorption_Homo sapiens_hsa049770.71917175
129Histidine metabolism_Homo sapiens_hsa003400.71756288
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71749873
131Peroxisome_Homo sapiens_hsa041460.70636025
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.68359187
133Type II diabetes mellitus_Homo sapiens_hsa049300.67712716
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67209624
135cAMP signaling pathway_Homo sapiens_hsa040240.66885478
136Osteoclast differentiation_Homo sapiens_hsa043800.66537956
137Tyrosine metabolism_Homo sapiens_hsa003500.65887191
138Measles_Homo sapiens_hsa051620.65643550
139Pyrimidine metabolism_Homo sapiens_hsa002400.64843708
140Sulfur metabolism_Homo sapiens_hsa009200.62751406
141Fatty acid elongation_Homo sapiens_hsa000620.60207156
142ErbB signaling pathway_Homo sapiens_hsa040120.59894287
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59804253
144Phagosome_Homo sapiens_hsa041450.58707414
145beta-Alanine metabolism_Homo sapiens_hsa004100.58632849
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.58195195
147Proteoglycans in cancer_Homo sapiens_hsa052050.58095073
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57716306
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56913890
150Glucagon signaling pathway_Homo sapiens_hsa049220.56607826
151Base excision repair_Homo sapiens_hsa034100.56070082
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55794212
153Chemical carcinogenesis_Homo sapiens_hsa052040.55769738
154Vibrio cholerae infection_Homo sapiens_hsa051100.55742126
155Thyroid hormone synthesis_Homo sapiens_hsa049180.55453191
156Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54970006
157Biosynthesis of amino acids_Homo sapiens_hsa012300.54774662
158Dorso-ventral axis formation_Homo sapiens_hsa043200.53081014
159Alzheimers disease_Homo sapiens_hsa050100.53069056
160Galactose metabolism_Homo sapiens_hsa000520.53048576
161HTLV-I infection_Homo sapiens_hsa051660.52863448
162Ovarian steroidogenesis_Homo sapiens_hsa049130.52670608
163Vascular smooth muscle contraction_Homo sapiens_hsa042700.51998058
164Tuberculosis_Homo sapiens_hsa051520.51939595
165Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50906147
166Retinol metabolism_Homo sapiens_hsa008300.50133386
167Hedgehog signaling pathway_Homo sapiens_hsa043400.49697531
168Cyanoamino acid metabolism_Homo sapiens_hsa004600.48519373
169Melanoma_Homo sapiens_hsa052180.47152291
170Chemokine signaling pathway_Homo sapiens_hsa040620.46788777
171Dilated cardiomyopathy_Homo sapiens_hsa054140.45969661
172Arginine and proline metabolism_Homo sapiens_hsa003300.45082955
173Oxidative phosphorylation_Homo sapiens_hsa001900.44473419
174Phototransduction_Homo sapiens_hsa047440.44126702
175Oocyte meiosis_Homo sapiens_hsa041140.44057465
176Tight junction_Homo sapiens_hsa045300.44032934
177Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43826654
178Fatty acid biosynthesis_Homo sapiens_hsa000610.43341038
179Central carbon metabolism in cancer_Homo sapiens_hsa052300.42932023
180Prolactin signaling pathway_Homo sapiens_hsa049170.42364457
181Amoebiasis_Homo sapiens_hsa051460.41786844
182Glutathione metabolism_Homo sapiens_hsa004800.41280323
183Toxoplasmosis_Homo sapiens_hsa051450.40285993
184Alcoholism_Homo sapiens_hsa050340.38235121
185Parkinsons disease_Homo sapiens_hsa050120.37871061
186Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37326968
187Small cell lung cancer_Homo sapiens_hsa052220.34778874
188Sphingolipid signaling pathway_Homo sapiens_hsa040710.34062568

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