MBD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.64302981
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.64302981
3antigen processing and presentation of endogenous antigen (GO:0019883)5.04827393
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33377031
5negative regulation of cell killing (GO:0031342)4.33377031
6alpha-linolenic acid metabolic process (GO:0036109)4.25524260
7response to muramyl dipeptide (GO:0032495)4.15407218
8positive regulation of gamma-delta T cell activation (GO:0046645)4.04171643
9detection of bacterium (GO:0016045)3.87115105
10valine metabolic process (GO:0006573)3.86076300
11complement activation, alternative pathway (GO:0006957)3.78742027
12detection of other organism (GO:0098543)3.76731400
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.74668837
14L-phenylalanine catabolic process (GO:0006559)3.74668837
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67580360
16thymic T cell selection (GO:0045061)3.66663786
17germinal center formation (GO:0002467)3.64913559
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.64229215
19L-phenylalanine metabolic process (GO:0006558)3.63358536
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.63358536
21urea metabolic process (GO:0019627)3.61884203
22urea cycle (GO:0000050)3.61884203
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.58669197
24kynurenine metabolic process (GO:0070189)3.58381081
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.56923300
26regulation of gamma-delta T cell differentiation (GO:0045586)3.51569432
27negative regulation of fibrinolysis (GO:0051918)3.51289593
28aromatic amino acid family catabolic process (GO:0009074)3.50849253
29B cell receptor signaling pathway (GO:0050853)3.48229769
30tolerance induction (GO:0002507)3.45275112
31indole-containing compound catabolic process (GO:0042436)3.43800464
32indolalkylamine catabolic process (GO:0046218)3.43800464
33tryptophan catabolic process (GO:0006569)3.43800464
34positive regulation of B cell differentiation (GO:0045579)3.40523487
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39630760
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.39630760
37modulation by symbiont of host immune response (GO:0052553)3.39630760
38positive regulation by symbiont of host defense response (GO:0052509)3.39630760
39modulation by symbiont of host defense response (GO:0052031)3.39630760
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39630760
41protein carboxylation (GO:0018214)3.36397729
42peptidyl-glutamic acid carboxylation (GO:0017187)3.36397729
43lysine metabolic process (GO:0006553)3.36252063
44lysine catabolic process (GO:0006554)3.36252063
45tryptophan metabolic process (GO:0006568)3.32840294
46positive regulation of fatty acid beta-oxidation (GO:0032000)3.31767806
47sulfur amino acid catabolic process (GO:0000098)3.31474102
48regulation of protein activation cascade (GO:2000257)3.29098372
49regulation of triglyceride catabolic process (GO:0010896)3.26848902
50regulation of gamma-delta T cell activation (GO:0046643)3.24838266
51phospholipid homeostasis (GO:0055091)3.24632390
52T cell selection (GO:0045058)3.24130112
53positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.22039935
54regulation of B cell receptor signaling pathway (GO:0050855)3.20921953
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20192155
56response to peptidoglycan (GO:0032494)3.18021851
57regulation of fatty acid beta-oxidation (GO:0031998)3.16445018
58nitrogen cycle metabolic process (GO:0071941)3.16321026
59regulation of cholesterol homeostasis (GO:2000188)3.16246636
60response to interleukin-15 (GO:0070672)3.14728515
61leukocyte aggregation (GO:0070486)3.14431420
62cysteine metabolic process (GO:0006534)3.13196480
63NIK/NF-kappaB signaling (GO:0038061)3.13087786
64negative regulation of cholesterol transport (GO:0032375)3.12121153
65negative regulation of sterol transport (GO:0032372)3.12121153
66regulation of complement activation (GO:0030449)3.11612103
672-oxoglutarate metabolic process (GO:0006103)3.11588042
68B cell homeostasis (GO:0001782)3.10163960
69bile acid biosynthetic process (GO:0006699)3.06383242
70negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.03703014
71high-density lipoprotein particle remodeling (GO:0034375)3.03316628
72low-density lipoprotein particle clearance (GO:0034383)3.02473968
73plasma lipoprotein particle clearance (GO:0034381)3.01925294
74regulation of type I interferon-mediated signaling pathway (GO:0060338)3.01692407
753-UTR-mediated mRNA stabilization (GO:0070935)3.00708213
76antigen processing and presentation via MHC class Ib (GO:0002475)3.00686962
77regulation of cholesterol storage (GO:0010885)3.00336769
78regulation of fibrinolysis (GO:0051917)2.99932494
79positive regulation of lipid catabolic process (GO:0050996)2.98850366
80glyoxylate metabolic process (GO:0046487)2.97041735
81positive regulation of histone deacetylation (GO:0031065)2.94691823
82positive T cell selection (GO:0043368)2.91972507
83embryonic process involved in female pregnancy (GO:0060136)2.89137871
84phospholipid efflux (GO:0033700)2.88712344
85detection of external biotic stimulus (GO:0098581)2.88597960
86negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88417646
87plasma lipoprotein particle assembly (GO:0034377)2.86822210
88macrophage activation involved in immune response (GO:0002281)2.85615412
89oxaloacetate metabolic process (GO:0006107)2.85135830
90tricarboxylic acid metabolic process (GO:0072350)2.84085703
91negative regulation of T cell mediated immunity (GO:0002710)2.82866157
92response to laminar fluid shear stress (GO:0034616)2.81251308
93protein-lipid complex assembly (GO:0065005)2.79411079
94reverse cholesterol transport (GO:0043691)2.78643243
95killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.77894167
96disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.77894167
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.77370000
98negative regulation of toll-like receptor signaling pathway (GO:0034122)2.75181554
99ethanol oxidation (GO:0006069)2.73786507
100histone H3-K36 demethylation (GO:0070544)2.73357995
101CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73287358
102pentose-phosphate shunt (GO:0006098)2.72115267
103cellular response to interleukin-15 (GO:0071350)2.72072068
104acute-phase response (GO:0006953)2.71114168
105dicarboxylic acid biosynthetic process (GO:0043650)2.70901197
106response to type I interferon (GO:0034340)2.70708630
107regulation of necroptotic process (GO:0060544)2.70445065
108response to host (GO:0075136)2.69209913
109response to host defenses (GO:0052200)2.69209913
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69209913
111cellular response to type I interferon (GO:0071357)2.68407161
112type I interferon signaling pathway (GO:0060337)2.68407161
113pinocytosis (GO:0006907)2.67103066
114positive regulation of triglyceride metabolic process (GO:0090208)2.67069788
115regulation of ARF protein signal transduction (GO:0032012)2.66726820
116bile acid metabolic process (GO:0008206)2.66605835
117regulation of dendritic cell antigen processing and presentation (GO:0002604)2.65887975
118modulation by symbiont of host cellular process (GO:0044068)2.65041782
119plasma lipoprotein particle remodeling (GO:0034369)2.62908947
120protein-lipid complex remodeling (GO:0034368)2.62908947
121macromolecular complex remodeling (GO:0034367)2.62908947
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62107349
123Peyers patch development (GO:0048541)2.62020984
124mucosal-associated lymphoid tissue development (GO:0048537)2.62020984
125complement activation, classical pathway (GO:0006958)2.61999528
126homocysteine metabolic process (GO:0050667)2.61521534
127amino-acid betaine metabolic process (GO:0006577)2.61235531
128activation of JUN kinase activity (GO:0007257)2.60534522
129complement activation (GO:0006956)2.57671422
130negative regulation of lymphocyte mediated immunity (GO:0002707)2.57618204
131regulation of interferon-beta biosynthetic process (GO:0045357)2.57592177
132regulation of humoral immune response (GO:0002920)2.57002723
133negative regulation of leukocyte mediated immunity (GO:0002704)2.56267787
134lymphocyte homeostasis (GO:0002260)2.55695171
135positive regulation of cellular amide metabolic process (GO:0034250)2.55250653
136acylglycerol homeostasis (GO:0055090)2.54502462
137triglyceride homeostasis (GO:0070328)2.54502462
138activation of MAPKKK activity (GO:0000185)2.54067113
139regulation of B cell differentiation (GO:0045577)2.52642442
140cellular modified amino acid catabolic process (GO:0042219)2.52365490
141positive thymic T cell selection (GO:0045059)2.51985433
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51625093
143T cell migration (GO:0072678)2.50889313
144negative regulation of interleukin-12 production (GO:0032695)2.50004044
145negative regulation of lipid transport (GO:0032369)2.49982903
146positive regulation of fatty acid oxidation (GO:0046321)2.49788085
147negative regulation of myotube differentiation (GO:0010832)2.49624735
148cytolysis (GO:0019835)2.49581411
149detection of biotic stimulus (GO:0009595)2.48863957
150JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.48556178
151modulation by virus of host process (GO:0019054)2.48213398
152cholesterol efflux (GO:0033344)2.48032390
153positive regulation of triglyceride biosynthetic process (GO:0010867)2.46852801
154NADPH regeneration (GO:0006740)2.46071325
155regulation of leukocyte degranulation (GO:0043300)2.45824519
156negative thymic T cell selection (GO:0045060)2.45729090
157regulation of integrin activation (GO:0033623)2.44064098
158positive regulation of granulocyte differentiation (GO:0030854)2.43491746
159serine family amino acid catabolic process (GO:0009071)2.42616567
160negative regulation of innate immune response (GO:0045824)2.42469596
161plasma lipoprotein particle organization (GO:0071827)2.41788726
162T cell homeostasis (GO:0043029)2.41446282
163negative regulation of phagocytosis (GO:0050765)2.40653700
164positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.40637143
165response to host immune response (GO:0052572)2.40404063
166response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.40404063
167protein-lipid complex subunit organization (GO:0071825)2.40390875
168signal complex assembly (GO:0007172)2.39924401
169mannose metabolic process (GO:0006013)2.39245030
170mature B cell differentiation involved in immune response (GO:0002313)2.39122523
171negative regulation of cell size (GO:0045792)2.37989706
172regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37981554
173positive regulation of humoral immune response (GO:0002922)2.37935965
174negative regulation of erythrocyte differentiation (GO:0045647)2.36969154
175negative T cell selection (GO:0043383)2.36349486
176interferon-gamma-mediated signaling pathway (GO:0060333)2.34827557
177regulation of T-helper 2 cell differentiation (GO:0045628)2.34293620
178neutrophil activation involved in immune response (GO:0002283)2.32449221
179regulation of ARF GTPase activity (GO:0032312)2.32262230
180stress fiber assembly (GO:0043149)2.31505652
181negative regulation of necroptotic process (GO:0060546)2.30916757
182positive regulation of Rap GTPase activity (GO:0032854)2.29810401
183immunoglobulin mediated immune response (GO:0016064)2.29496072
184leukocyte homeostasis (GO:0001776)2.29422325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.38263160
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.86433801
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.85313676
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.75213298
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.63561495
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.63137633
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.97957833
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91353122
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.83494452
10MYC_22102868_ChIP-Seq_BL_Human2.80017516
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78920431
12E2F7_22180533_ChIP-Seq_HELA_Human2.59030412
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.57289864
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.50408694
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.41090225
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36968625
17GATA1_22025678_ChIP-Seq_K562_Human2.31396230
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28619669
19VDR_21846776_ChIP-Seq_THP-1_Human2.22524089
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.22433678
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21074754
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.19713795
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18778397
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17498521
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16349541
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11391131
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10836003
28SCL_19346495_ChIP-Seq_HPC-7_Human2.07884458
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02620248
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99199325
31MAF_26560356_Chip-Seq_TH1_Human1.97659655
32CLOCK_20551151_ChIP-Seq_293T_Human1.95316325
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91943421
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.90127223
35TCF7_22412390_ChIP-Seq_EML_Mouse1.87361918
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80813934
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78902948
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72351663
39* UTX_26944678_Chip-Seq_JUKART_Human1.72306402
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70040568
41VDR_24763502_ChIP-Seq_THP-1_Human1.65553263
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65189025
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65131495
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64751655
45MYB_26560356_Chip-Seq_TH2_Human1.64221005
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60304551
47MYB_26560356_Chip-Seq_TH1_Human1.56163926
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54715195
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.52794733
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52695931
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.51659299
52RUNX_20019798_ChIP-Seq_JUKART_Human1.51579728
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50166279
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49172824
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47372846
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47207345
57KDM2B_26808549_Chip-Seq_K562_Human1.46276769
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45190543
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45120038
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44657368
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40720894
62SPI1_23127762_ChIP-Seq_K562_Human1.39556341
63* KDM2B_26808549_Chip-Seq_DND41_Human1.38114560
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37190989
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32967845
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.31467199
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30903394
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.30331941
69* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28755313
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28664748
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28618149
72SPI1_23547873_ChIP-Seq_NB4_Human1.28335769
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27851230
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26061934
75* SA1_27219007_Chip-Seq_ERYTHROID_Human1.25409060
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24725663
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23412960
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23001092
79* LXR_22292898_ChIP-Seq_THP-1_Human1.22927362
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20436026
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20417302
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20263108
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18604763
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18107284
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18104620
86MAF_26560356_Chip-Seq_TH2_Human1.17334586
87P68_20966046_ChIP-Seq_HELA_Human1.16819388
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16421678
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.16314473
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13209596
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12213257
92SMC4_20622854_ChIP-Seq_HELA_Human1.11269582
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10310768
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10184420
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09945534
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08145236
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07686665
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07535439
99GATA3_27048872_Chip-Seq_THYMUS_Human1.06469929
100NCOR1_26117541_ChIP-Seq_K562_Human1.05392458
101P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05051372
102BP1_19119308_ChIP-ChIP_Hs578T_Human1.04958301
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03574714
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02346241
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01826030
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01768954
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01001884
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00640160
109CREB1_26743006_Chip-Seq_LNCaP_Human1.00549148
110BCOR_27268052_Chip-Seq_Bcells_Human1.00303644
111PU_27001747_Chip-Seq_BMDM_Mouse1.00242531
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98808372
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98576871
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.98437014
115GATA1_19941826_ChIP-Seq_K562_Human0.98272797
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96968736
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96907911
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96873720
119GATA2_19941826_ChIP-Seq_K562_Human0.96547353
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94719496
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93056598
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92804159
123FOXA2_19822575_ChIP-Seq_HepG2_Human0.91933871
124RACK7_27058665_Chip-Seq_MCF-7_Human0.91903068
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90873737
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90634408
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.89943636
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89728225
129ZNF263_19887448_ChIP-Seq_K562_Human0.88698261
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87856551
131CIITA_25753668_ChIP-Seq_RAJI_Human0.85945394
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81956992
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.81395956
134GATA6_25053715_ChIP-Seq_YYC3_Human0.79820296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.08165807
2MP0005360_urolithiasis3.89248447
3MP0005365_abnormal_bile_salt3.42184483
4MP0005085_abnormal_gallbladder_physiolo2.89820176
5MP0009840_abnormal_foam_cell2.48626073
6MP0001835_abnormal_antigen_presentation2.41633224
7MP0003191_abnormal_cellular_cholesterol2.38405638
8MP0010329_abnormal_lipoprotein_level2.35402510
9MP0003300_gastrointestinal_ulcer2.35087029
10MP0005451_abnormal_body_composition2.32782377
11MP0003252_abnormal_bile_duct2.29994201
12MP0003436_decreased_susceptibility_to2.29874036
13MP0008875_abnormal_xenobiotic_pharmacok2.25089923
14MP0003303_peritoneal_inflammation2.22229957
15MP0010234_abnormal_vibrissa_follicle2.18299341
16MP0000685_abnormal_immune_system2.05396632
17MP0008260_abnormal_autophagy1.97689598
18MP0005464_abnormal_platelet_physiology1.94115027
19MP0000609_abnormal_liver_physiology1.88162247
20MP0003828_pulmonary_edema1.86097652
21MP0003656_abnormal_erythrocyte_physiolo1.85138102
22MP0002138_abnormal_hepatobiliary_system1.81626609
23MP0009785_altered_susceptibility_to1.80333329
24MP0003705_abnormal_hypodermis_morpholog1.78951208
25MP0005083_abnormal_biliary_tract1.78437215
26MP0002796_impaired_skin_barrier1.73924346
27MP0001800_abnormal_humoral_immune1.73604122
28MP0003453_abnormal_keratinocyte_physiol1.72703165
29MP0002166_altered_tumor_susceptibility1.68761719
30MP0004381_abnormal_hair_follicle1.67953543
31MP0005025_abnormal_response_to1.65620019
32MP0005387_immune_system_phenotype1.63898343
33MP0001790_abnormal_immune_system1.63898343
34MP0005671_abnormal_response_to1.62793792
35MP0003091_abnormal_cell_migration1.61767113
36MP0002419_abnormal_innate_immunity1.60863967
37MP0005397_hematopoietic_system_phenotyp1.55992489
38MP0001545_abnormal_hematopoietic_system1.55992489
39MP0002452_abnormal_antigen_presenting1.53868980
40MP0003724_increased_susceptibility_to1.53120972
41MP0005058_abnormal_lysosome_morphology1.51343089
42MP0001666_abnormal_nutrient_absorption1.49777736
43MP0010352_gastrointestinal_tract_polyps1.48381973
44MP0002396_abnormal_hematopoietic_system1.48302693
45MP0005319_abnormal_enzyme/_coenzyme1.46107916
46MP0001849_ear_inflammation1.44514184
47MP0005000_abnormal_immune_tolerance1.43395947
48MP0004947_skin_inflammation1.43096615
49MP0002723_abnormal_immune_serum1.43095713
50MP0002009_preneoplasia1.41708956
51MP0010155_abnormal_intestine_physiology1.39389864
52MP0002420_abnormal_adaptive_immunity1.39051628
53MP0001819_abnormal_immune_cell1.38626297
54MP0002398_abnormal_bone_marrow1.38169327
55MP0009278_abnormal_bone_marrow1.37508628
56MP0003763_abnormal_thymus_physiology1.36168566
57MP0008469_abnormal_protein_level1.34893295
58MP0003806_abnormal_nucleotide_metabolis1.34810078
59MP0001845_abnormal_inflammatory_respons1.34110658
60MP0009764_decreased_sensitivity_to1.32040734
61MP0005076_abnormal_cell_differentiation1.31594080
62MP0004185_abnormal_adipocyte_glucose1.29857550
63MP0005409_darkened_coat_color1.28646836
64MP0002118_abnormal_lipid_homeostasis1.28262561
65MP0006082_CNS_inflammation1.26634258
66MP0001348_abnormal_lacrimal_gland1.26140608
67MP0000689_abnormal_spleen_morphology1.24737271
68MP0003172_abnormal_lysosome_physiology1.24048168
69MP0005670_abnormal_white_adipose1.22499680
70MP0000716_abnormal_immune_system1.22364162
71MP0000598_abnormal_liver_morphology1.22238525
72MP0002998_abnormal_bone_remodeling1.22147700
73MP0001853_heart_inflammation1.21178129
74MP0001533_abnormal_skeleton_physiology1.21112700
75MP0003329_amyloid_beta_deposits1.20371849
76MP0004130_abnormal_muscle_cell1.20354310
77MP0004808_abnormal_hematopoietic_stem1.19551599
78MP0004264_abnormal_extraembryonic_tissu1.18875709
79MP0002722_abnormal_immune_system1.18399155
80MP0002006_tumorigenesis1.18232328
81MP0002405_respiratory_system_inflammati1.15218547
82MP0009763_increased_sensitivity_to1.13975049
83MP0005332_abnormal_amino_acid1.13873075
84MP0001851_eye_inflammation1.13574412
85MP0003566_abnormal_cell_adhesion1.13369955
86MP0006054_spinal_hemorrhage1.12701789
87MP0005584_abnormal_enzyme/coenzyme_acti1.10768494
88MP0002429_abnormal_blood_cell1.10534015
89MP0001873_stomach_inflammation1.09989321
90MP0005501_abnormal_skin_physiology1.09751519
91MP0009643_abnormal_urine_homeostasis1.08005448
92MP0000604_amyloidosis1.05977444
93MP0001216_abnormal_epidermal_layer1.05423369
94MP0002148_abnormal_hypersensitivity_rea1.01199645
95MP0009931_abnormal_skin_appearance0.98880742
96MP0004510_myositis0.97446803
97MP0000733_abnormal_muscle_development0.97026133
98MP0005310_abnormal_salivary_gland0.96365246
99MP0005666_abnormal_adipose_tissue0.94859343
100MP0002060_abnormal_skin_morphology0.94409159
101MP0005023_abnormal_wound_healing0.93142274
102MP0008004_abnormal_stomach_pH0.92906569
103MP0000579_abnormal_nail_morphology0.90627651
104MP0002877_abnormal_melanocyte_morpholog0.88027679
105MP0000465_gastrointestinal_hemorrhage0.87784905
106MP0000858_altered_metastatic_potential0.86607031
107MP0000678_abnormal_parathyroid_gland0.85690379
108MP0003075_altered_response_to0.85369991
109MP0003279_aneurysm0.84964624
110MP0000015_abnormal_ear_pigmentation0.84653818
111MP0000343_altered_response_to0.84514566
112MP0000703_abnormal_thymus_morphology0.84020714
113MP0005375_adipose_tissue_phenotype0.83347304
114MP0002933_joint_inflammation0.83112622
115MP0009333_abnormal_splenocyte_physiolog0.82922060
116MP0005275_abnormal_skin_tensile0.82765771
117MP0001764_abnormal_homeostasis0.82556858
118MP0005621_abnormal_cell_physiology0.81689929
119MP0002254_reproductive_system_inflammat0.81030776
120MP0010307_abnormal_tumor_latency0.79693585
121MP0003866_abnormal_defecation0.79400554
122MP0000490_abnormal_crypts_of0.79111888
123MP0002136_abnormal_kidney_physiology0.78771263
124MP0005390_skeleton_phenotype0.78739725
125MP0003045_fibrosis0.78604932
126MP0009765_abnormal_xenobiotic_induced0.77935276
127MP0009115_abnormal_fat_cell0.77707089
128MP0000569_abnormal_digit_pigmentation0.77489498
129MP0005334_abnormal_fat_pad0.77479369
130MP0003186_abnormal_redox_activity0.77323791
131MP0005166_decreased_susceptibility_to0.77107724
132MP0001915_intracranial_hemorrhage0.73981915
133MP0009642_abnormal_blood_homeostasis0.73405017
134MP0008961_abnormal_basal_metabolism0.73342197
135MP0002971_abnormal_brown_adipose0.73213957
136MP0003183_abnormal_peptide_metabolism0.72925798
137MP0003448_altered_tumor_morphology0.72016745
138MP0002970_abnormal_white_adipose0.71665500
139MP0003690_abnormal_glial_cell0.71343531
140MP0000767_abnormal_smooth_muscle0.68583157

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.37252033
2Increased IgE level (HP:0003212)3.80032189
3Complement deficiency (HP:0004431)3.71682103
4Xanthomatosis (HP:0000991)3.56055980
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.52699818
6Intrahepatic cholestasis (HP:0001406)3.33293267
7Recurrent gram-negative bacterial infections (HP:0005420)3.32494092
8Hypobetalipoproteinemia (HP:0003563)3.26743231
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.08685826
10Abnormality of the common coagulation pathway (HP:0010990)3.02324342
11Abnormality of nail color (HP:0100643)3.02170268
12Myocardial infarction (HP:0001658)2.98256696
13Hyperlipoproteinemia (HP:0010980)2.96300089
14Abnormality of complement system (HP:0005339)2.95662679
15Joint hemorrhage (HP:0005261)2.83534108
16Prolonged partial thromboplastin time (HP:0003645)2.83366911
17Mediastinal lymphadenopathy (HP:0100721)2.81726646
18Eczematoid dermatitis (HP:0000976)2.80078654
19Autoimmune thrombocytopenia (HP:0001973)2.79754439
20Gingival bleeding (HP:0000225)2.73991378
21Elevated erythrocyte sedimentation rate (HP:0003565)2.67747909
22Systemic lupus erythematosus (HP:0002725)2.65790910
23Recurrent viral infections (HP:0004429)2.60693341
24Abnormality of macrophages (HP:0004311)2.60673999
25Obstructive sleep apnea (HP:0002870)2.56188697
26Mitral stenosis (HP:0001718)2.55253319
27Esophageal varix (HP:0002040)2.52009134
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.49779554
29Periodontitis (HP:0000704)2.48086238
30Hyperammonemia (HP:0001987)2.46792746
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.45987728
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.45703856
33Hypolipoproteinemia (HP:0010981)2.44966557
34Panhypogammaglobulinemia (HP:0003139)2.44136265
35Gastrointestinal stroma tumor (HP:0100723)2.41469012
36Epidermoid cyst (HP:0200040)2.39142501
37Broad face (HP:0000283)2.38412309
38Ketosis (HP:0001946)2.37881094
39Exercise-induced myalgia (HP:0003738)2.37243937
40Recurrent fungal infections (HP:0002841)2.37026714
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.36752224
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.36458304
43Epistaxis (HP:0000421)2.34776698
44Spontaneous hematomas (HP:0007420)2.34073970
45Abnormality of the intrinsic pathway (HP:0010989)2.31599361
46Recurrent bacterial skin infections (HP:0005406)2.30592069
47Asymmetric septal hypertrophy (HP:0001670)2.30543951
48Interstitial pulmonary disease (HP:0006530)2.29395606
49Recurrent cutaneous fungal infections (HP:0011370)2.28051342
50Chronic mucocutaneous candidiasis (HP:0002728)2.28051342
51Thrombocytosis (HP:0001894)2.26153468
52Gingivitis (HP:0000230)2.26083280
53Cellulitis (HP:0100658)2.24205803
54Hypoglycemic coma (HP:0001325)2.23934937
55Colitis (HP:0002583)2.23338506
56Emphysema (HP:0002097)2.23164592
57Hepatocellular carcinoma (HP:0001402)2.22432150
58Abnormal platelet function (HP:0011869)2.22407653
59Impaired platelet aggregation (HP:0003540)2.22407653
60Hypoplasia of the thymus (HP:0000778)2.22275988
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.21937863
62Hypercholesterolemia (HP:0003124)2.20184952
63Abnormal platelet volume (HP:0011876)2.20172303
64Distal lower limb amyotrophy (HP:0008944)2.19039978
65Abnormality of fatty-acid metabolism (HP:0004359)2.17692132
66Recurrent bronchitis (HP:0002837)2.15805174
67Fat malabsorption (HP:0002630)2.15503106
68Gastrointestinal infarctions (HP:0005244)2.14819963
69Hypoalphalipoproteinemia (HP:0003233)2.14120651
70Recurrent abscess formation (HP:0002722)2.13514918
71Milia (HP:0001056)2.12648304
72Poikilocytosis (HP:0004447)2.12609521
73Hyperbilirubinemia (HP:0002904)2.12074962
74Acanthocytosis (HP:0001927)2.12059384
75Thick nail (HP:0001805)2.11598124
76Spastic diplegia (HP:0001264)2.09301798
77Increased mean platelet volume (HP:0011877)2.09170196
78Myositis (HP:0100614)2.08341970
79Abnormality of the fingertips (HP:0001211)2.08128487
80IgM deficiency (HP:0002850)2.07641176
81Thrombophlebitis (HP:0004418)2.07346109
82Pustule (HP:0200039)2.06989069
83Chronic otitis media (HP:0000389)2.06181175
84Arterial thrombosis (HP:0004420)2.05115395
85T lymphocytopenia (HP:0005403)2.03736937
86Supranuclear gaze palsy (HP:0000605)2.02694043
87Verrucae (HP:0200043)2.02341660
88Papilloma (HP:0012740)2.02341660
89Neurofibrillary tangles (HP:0002185)2.01248177
90Distal lower limb muscle weakness (HP:0009053)2.00793451
91Amyloidosis (HP:0011034)2.00305741
92Atrophic scars (HP:0001075)2.00069358
93Peritonitis (HP:0002586)1.99571231
94Spondylolisthesis (HP:0003302)1.98813083
95Dysostosis multiplex (HP:0000943)1.97474743
96Polycythemia (HP:0001901)1.96084811
97Gastrointestinal inflammation (HP:0004386)1.95600676
98Urticaria (HP:0001025)1.95600240
99Viral hepatitis (HP:0006562)1.95570659
100Combined immunodeficiency (HP:0005387)1.95558326
101Abnormality of T cell number (HP:0011839)1.94255418
102Chest pain (HP:0100749)1.93669014
103Orchitis (HP:0100796)1.93399463
104Prolonged bleeding time (HP:0003010)1.92274318
105Inflammation of the large intestine (HP:0002037)1.92250398
106Menorrhagia (HP:0000132)1.91946854
107Skin ulcer (HP:0200042)1.91465323
108Recurrent skin infections (HP:0001581)1.90970429
109Thin bony cortex (HP:0002753)1.90749165
110Abnormality of T cells (HP:0002843)1.90206131
111Chronic obstructive pulmonary disease (HP:0006510)1.89593915
112Obstructive lung disease (HP:0006536)1.89593915
113Nasal polyposis (HP:0100582)1.88834385
114Agammaglobulinemia (HP:0004432)1.88169521
115Neuronal loss in central nervous system (HP:0002529)1.86398450
116Osteomyelitis (HP:0002754)1.85586666
117Sepsis (HP:0100806)1.85466794
118Abnormality of T cell physiology (HP:0011840)1.85086753
119Abnormality of purine metabolism (HP:0004352)1.85066558
120Segmental peripheral demyelination/remyelination (HP:0003481)1.83983843
121Abnormality of nucleobase metabolism (HP:0010932)1.83418763
122Abnormal blistering of the skin (HP:0008066)1.82927704
123Late onset (HP:0003584)1.82022579
124Pulmonary infiltrates (HP:0002113)1.81726328
125Long palpebral fissure (HP:0000637)1.81600077
126Vasculitis (HP:0002633)1.81491155
127Loss of speech (HP:0002371)1.81216790
128Hemorrhage of the eye (HP:0011885)1.80949521
129Hyperacusis (HP:0010780)1.80680258
130Persistence of primary teeth (HP:0006335)1.80506230
131Protrusio acetabuli (HP:0003179)1.80376845
132Ketoacidosis (HP:0001993)1.80332203
133Abnormality of iron homeostasis (HP:0011031)1.80124444
134Abnormality of pyrimidine metabolism (HP:0004353)1.80123174
135Vascular calcification (HP:0004934)1.79868833
136Abnormality of the nasal mucosa (HP:0000433)1.79554644
137Tetraparesis (HP:0002273)1.79255872
138Hepatitis (HP:0012115)1.79169913
139Dilatation of the ascending aorta (HP:0005111)1.79123683
140Cerebral aneurysm (HP:0004944)1.78896709
141Polygenic inheritance (HP:0010982)1.78583665
142Meningitis (HP:0001287)1.77962411
143Plantar hyperkeratosis (HP:0007556)1.77873491
144Vacuolated lymphocytes (HP:0001922)1.76825170
145Abnormality of transition element cation homeostasis (HP:0011030)1.76541906
146Cholelithiasis (HP:0001081)1.76078200
147Fatigue (HP:0012378)1.74927037
148Aneurysm (HP:0002617)1.72565912
149Cerebral inclusion bodies (HP:0100314)1.71559450
150Distal upper limb amyotrophy (HP:0007149)1.70870218
151Upper limb amyotrophy (HP:0009129)1.70870218
152Stomatitis (HP:0010280)1.70279488
153Onycholysis (HP:0001806)1.69802683
154Slow saccadic eye movements (HP:0000514)1.68707723
155Optic neuritis (HP:0100653)1.68639644
156Retrobulbar optic neuritis (HP:0100654)1.68639644
157Restrictive lung disease (HP:0002091)1.68513706
158Increased variability in muscle fiber diameter (HP:0003557)1.68139873
159Hypergammaglobulinemia (HP:0010702)1.67893155
160Syringomyelia (HP:0003396)1.66611675
161Spinal cord lesions (HP:0100561)1.66611675
162Abnormality of the columella (HP:0009929)1.65052918
163Arterial tortuosity (HP:0005116)1.64882177
164Erythema (HP:0010783)1.64240467
165Increased cerebral lipofuscin (HP:0011813)1.64145135
166Hypertensive crisis (HP:0100735)1.63406765
167Keratoconjunctivitis sicca (HP:0001097)1.63030595
168Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62935287
169Abnormality of skeletal muscle fiber size (HP:0012084)1.62192807
170Abnormality of the thoracic spine (HP:0100711)1.61322615
171Increased serum ferritin (HP:0003281)1.61036961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.56102443
2TRIB34.33753319
3ERN14.31611571
4MAP4K13.16262095
5SIK12.91735254
6PKN22.88129903
7MAP3K102.83763876
8EEF2K2.57047850
9SMG12.38355863
10RIPK42.26858982
11TYK22.26565165
12TAOK32.25029899
13FGFR42.24182697
14TBK12.02554174
15JAK31.84139318
16STK101.83463212
17PTK61.81773404
18JAK11.80965458
19ZAP701.71561790
20GRK61.67504726
21MAP2K31.65322558
22BCKDK1.61221789
23KIT1.55041069
24CSF1R1.53753858
25LRRK21.50842189
26ICK1.49150928
27RIPK11.44193297
28KSR21.40431915
29TTN1.36301122
30BTK1.35770206
31IKBKE1.32182237
32NEK91.31074929
33MARK21.26637733
34FLT31.25763874
35MAP3K141.23086473
36BRD41.21151447
37TXK1.15588596
38MAP2K21.15027823
39TGFBR21.12487272
40BLK1.12481740
41JAK21.12391225
42KDR1.12126762
43SYK1.11148099
44FGFR31.10605009
45MAPK71.10512700
46MAPK111.10495766
47MAP3K11.06480197
48TAOK21.06420896
49TNK21.03877430
50CHUK1.03492629
51PRKD21.02425816
52PIM11.01722197
53CDC42BPA1.01215466
54CDK61.01209396
55CDK120.99661098
56SIK30.98568278
57LMTK20.97843991
58CSK0.94205598
59SIK20.92073473
60IKBKB0.91364009
61ARAF0.90110108
62ITK0.86340322
63HCK0.86325590
64FGR0.84860416
65RPS6KA40.81261778
66MAP3K70.80367107
67EPHB10.80096444
68SCYL20.77849467
69PDGFRA0.77807625
70TAOK10.77806149
71CDK40.76722428
72IRAK20.75704610
73MAP3K90.74775445
74PDPK10.74188417
75LCK0.73121244
76MAP3K50.73045413
77IRAK40.71440978
78PIM20.70354375
79BMX0.70173252
80MTOR0.69975219
81CAMK1D0.69958765
82PAK40.66404806
83MOS0.66158656
84STK40.66117621
85MAP3K30.66113394
86CAMKK10.64634496
87LYN0.61909785
88MATK0.61803947
89MAP3K80.61162139
90SGK30.60496929
91TGFBR10.59755779
92MAP3K130.59319551
93PRKCH0.58419075
94PRKD30.57235723
95MAPK40.57010971
96RAF10.56302611
97DYRK1B0.56114198
98CAMK1G0.56077781
99TESK20.55885910
100IRAK30.55198256
101FES0.53344018
102MAP3K60.52179576
103MAP3K110.50132515
104NEK20.49622928
105HIPK20.48469684
106MST1R0.47415617
107PRKCQ0.47039321
108MARK30.45893100
109ERBB20.45786135
110RPS6KA60.45423275
111EPHA30.44569168
112TEC0.44553359
113PDGFRB0.44538059
114EGFR0.43632388
115RPS6KA20.42350585
116IRAK10.42151679
117PDK10.40783220
118RPS6KB20.40596007
119CDK90.40449678
120FRK0.40434888
121TYRO30.40250100
122RET0.39199318
123STK30.38798472
124RPS6KC10.38541086
125RPS6KL10.38541086
126MAPKAPK30.37869037
127MELK0.37714955
128MAPK120.37383149
129MAPK30.36906562

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.23216094
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13785475
3Nitrogen metabolism_Homo sapiens_hsa009102.71617459
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48462681
5Arginine biosynthesis_Homo sapiens_hsa002202.29799292
6Complement and coagulation cascades_Homo sapiens_hsa046102.29217807
7Staphylococcus aureus infection_Homo sapiens_hsa051502.23926018
8Caffeine metabolism_Homo sapiens_hsa002322.22778092
9Fatty acid degradation_Homo sapiens_hsa000712.13732749
10Tryptophan metabolism_Homo sapiens_hsa003801.99809223
11PPAR signaling pathway_Homo sapiens_hsa033201.78184807
12Selenocompound metabolism_Homo sapiens_hsa004501.68722983
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68514258
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60582063
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59826964
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59460192
17Primary immunodeficiency_Homo sapiens_hsa053401.53963180
18Leishmaniasis_Homo sapiens_hsa051401.48362343
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47301755
20Allograft rejection_Homo sapiens_hsa053301.43887024
21Fatty acid metabolism_Homo sapiens_hsa012121.37953739
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.37269752
23Lysine degradation_Homo sapiens_hsa003101.37164954
24VEGF signaling pathway_Homo sapiens_hsa043701.37092793
25Peroxisome_Homo sapiens_hsa041461.34736878
26Autoimmune thyroid disease_Homo sapiens_hsa053201.31117216
27Notch signaling pathway_Homo sapiens_hsa043301.30367351
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30336929
29B cell receptor signaling pathway_Homo sapiens_hsa046621.30040687
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.28513086
31ABC transporters_Homo sapiens_hsa020101.23315620
32Graft-versus-host disease_Homo sapiens_hsa053321.21600330
33Propanoate metabolism_Homo sapiens_hsa006401.18050917
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.17556956
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15296694
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13768398
37Starch and sucrose metabolism_Homo sapiens_hsa005001.13311327
38Measles_Homo sapiens_hsa051621.12675260
39Osteoclast differentiation_Homo sapiens_hsa043801.11961163
40Endometrial cancer_Homo sapiens_hsa052131.10861773
41Pentose phosphate pathway_Homo sapiens_hsa000301.09693846
42GnRH signaling pathway_Homo sapiens_hsa049121.08722770
43Renal cell carcinoma_Homo sapiens_hsa052111.07924683
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05676050
45Chemokine signaling pathway_Homo sapiens_hsa040621.05478957
46Carbon metabolism_Homo sapiens_hsa012001.05101425
47Chronic myeloid leukemia_Homo sapiens_hsa052201.04479791
48Insulin resistance_Homo sapiens_hsa049311.04127914
49Bile secretion_Homo sapiens_hsa049761.00362078
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.00209620
51Legionellosis_Homo sapiens_hsa051340.99873188
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.99800107
53mTOR signaling pathway_Homo sapiens_hsa041500.99705807
54ErbB signaling pathway_Homo sapiens_hsa040120.97975891
55Prolactin signaling pathway_Homo sapiens_hsa049170.97254975
56Biosynthesis of amino acids_Homo sapiens_hsa012300.97103627
57beta-Alanine metabolism_Homo sapiens_hsa004100.96838371
58Inositol phosphate metabolism_Homo sapiens_hsa005620.96347631
59Toxoplasmosis_Homo sapiens_hsa051450.96229003
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.95860774
61Bladder cancer_Homo sapiens_hsa052190.93612938
62Colorectal cancer_Homo sapiens_hsa052100.92160921
63Prion diseases_Homo sapiens_hsa050200.91653490
64Acute myeloid leukemia_Homo sapiens_hsa052210.90165383
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89669191
66Endocytosis_Homo sapiens_hsa041440.87294980
67Glioma_Homo sapiens_hsa052140.87150749
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86834950
69FoxO signaling pathway_Homo sapiens_hsa040680.86448096
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.85312156
71Choline metabolism in cancer_Homo sapiens_hsa052310.84897271
72Apoptosis_Homo sapiens_hsa042100.84460944
73HTLV-I infection_Homo sapiens_hsa051660.83950265
74Amoebiasis_Homo sapiens_hsa051460.83119029
75Chemical carcinogenesis_Homo sapiens_hsa052040.82642262
76Prostate cancer_Homo sapiens_hsa052150.82518015
77Sulfur relay system_Homo sapiens_hsa041220.82225624
78Asthma_Homo sapiens_hsa053100.82164095
79Pertussis_Homo sapiens_hsa051330.81581998
80Salmonella infection_Homo sapiens_hsa051320.81043873
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81000140
82Antigen processing and presentation_Homo sapiens_hsa046120.80091638
83Viral carcinogenesis_Homo sapiens_hsa052030.79714170
84Viral myocarditis_Homo sapiens_hsa054160.78427323
85Epstein-Barr virus infection_Homo sapiens_hsa051690.77834476
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.76335117
87Influenza A_Homo sapiens_hsa051640.76266991
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76256318
89Estrogen signaling pathway_Homo sapiens_hsa049150.75933336
90TNF signaling pathway_Homo sapiens_hsa046680.75274062
91Pancreatic cancer_Homo sapiens_hsa052120.74626612
92Type I diabetes mellitus_Homo sapiens_hsa049400.74506275
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73771295
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73316972
95MAPK signaling pathway_Homo sapiens_hsa040100.72570658
96Insulin signaling pathway_Homo sapiens_hsa049100.72410336
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72182068
98Histidine metabolism_Homo sapiens_hsa003400.72166986
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71393661
100Fat digestion and absorption_Homo sapiens_hsa049750.71383616
101One carbon pool by folate_Homo sapiens_hsa006700.70874512
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70627620
103Phenylalanine metabolism_Homo sapiens_hsa003600.69621455
104Small cell lung cancer_Homo sapiens_hsa052220.69605071
105Butanoate metabolism_Homo sapiens_hsa006500.69261052
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69199224
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68399508
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68369284
109Pyruvate metabolism_Homo sapiens_hsa006200.67803086
110Focal adhesion_Homo sapiens_hsa045100.67332055
111Non-small cell lung cancer_Homo sapiens_hsa052230.67156619
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.66939709
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66819447
114Hepatitis B_Homo sapiens_hsa051610.66414723
115Lysosome_Homo sapiens_hsa041420.66050110
116Fatty acid biosynthesis_Homo sapiens_hsa000610.65272718
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65023181
118Tuberculosis_Homo sapiens_hsa051520.64679007
119Thyroid cancer_Homo sapiens_hsa052160.64347297
120Hematopoietic cell lineage_Homo sapiens_hsa046400.64031947
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.63828512
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63666709
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63529228
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.63485832
125Hepatitis C_Homo sapiens_hsa051600.63310995
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.63162954
127Long-term potentiation_Homo sapiens_hsa047200.63136819
128T cell receptor signaling pathway_Homo sapiens_hsa046600.62836705
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62479526
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62461634
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62398964
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62243632
133Herpes simplex infection_Homo sapiens_hsa051680.62114397
134Proteoglycans in cancer_Homo sapiens_hsa052050.61862179
135Glycerolipid metabolism_Homo sapiens_hsa005610.61691190
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61677591
137Phagosome_Homo sapiens_hsa041450.59902594
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.59553090
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59364317
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58208209
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58161515
142Dorso-ventral axis formation_Homo sapiens_hsa043200.58033815
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56998452
144Retinol metabolism_Homo sapiens_hsa008300.56705675
145MicroRNAs in cancer_Homo sapiens_hsa052060.56438883
146Other glycan degradation_Homo sapiens_hsa005110.55907574
147Malaria_Homo sapiens_hsa051440.54982596
148AMPK signaling pathway_Homo sapiens_hsa041520.53711214
149Shigellosis_Homo sapiens_hsa051310.50159558
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50066237
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49883560
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48911244
153Platelet activation_Homo sapiens_hsa046110.47655387

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