MBD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)5.24489386
2regulation of mammary gland epithelial cell proliferation (GO:0033599)5.00029743
3DNA unwinding involved in DNA replication (GO:0006268)4.88563316
4viral transcription (GO:0019083)4.71046814
5translational termination (GO:0006415)4.56563574
6planar cell polarity pathway involved in neural tube closure (GO:0090179)4.44461466
7translational elongation (GO:0006414)4.29538124
8heterochromatin organization (GO:0070828)4.28685550
9protein localization to kinetochore (GO:0034501)4.27265714
10ribosomal small subunit assembly (GO:0000028)4.23637404
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.12202039
12translational initiation (GO:0006413)4.09933531
13negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.07730280
14peptidyl-arginine omega-N-methylation (GO:0035247)4.06796470
15DNA deamination (GO:0045006)4.06706602
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.04367062
17protein localization to endosome (GO:0036010)3.97319469
18maturation of SSU-rRNA (GO:0030490)3.93748736
19negative regulation of erythrocyte differentiation (GO:0045647)3.91653551
20folic acid-containing compound biosynthetic process (GO:0009396)3.88930431
21regulation of translational fidelity (GO:0006450)3.88348290
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.84054834
23DNA strand elongation involved in DNA replication (GO:0006271)3.77735524
24maternal placenta development (GO:0001893)3.73888479
25ribosomal small subunit biogenesis (GO:0042274)3.73775280
26adherens junction assembly (GO:0034333)3.70048118
27negative regulation of RNA splicing (GO:0033119)3.65614596
28regulation of early endosome to late endosome transport (GO:2000641)3.64573553
29mannose metabolic process (GO:0006013)3.62670533
30viral life cycle (GO:0019058)3.54678139
31DNA strand elongation (GO:0022616)3.53797630
32cellular protein complex disassembly (GO:0043624)3.53115137
33protein localization to chromosome, centromeric region (GO:0071459)3.52587717
34histone arginine methylation (GO:0034969)3.52203532
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51744237
36protein retention in ER lumen (GO:0006621)3.49919090
37DNA replication initiation (GO:0006270)3.48583068
38DNA replication-dependent nucleosome organization (GO:0034723)3.48488636
39DNA replication-dependent nucleosome assembly (GO:0006335)3.48488636
40UV protection (GO:0009650)3.47538849
41protein complex disassembly (GO:0043241)3.46907198
42pre-miRNA processing (GO:0031054)3.43236027
43peptidyl-arginine N-methylation (GO:0035246)3.42495342
44peptidyl-arginine methylation (GO:0018216)3.42495342
45protein targeting to ER (GO:0045047)3.41824994
46cell-substrate adherens junction assembly (GO:0007045)3.35630426
47focal adhesion assembly (GO:0048041)3.35630426
48cotranslational protein targeting to membrane (GO:0006613)3.35475822
49regulation of translational termination (GO:0006449)3.35221622
50negative regulation of mRNA processing (GO:0050686)3.34729985
51negative regulation of cell size (GO:0045792)3.33709970
52semaphorin-plexin signaling pathway (GO:0071526)3.33670487
53regulation of hippo signaling (GO:0035330)3.31903320
54mitotic nuclear envelope disassembly (GO:0007077)3.30325428
55regulation of gene silencing by RNA (GO:0060966)3.25500175
56regulation of posttranscriptional gene silencing (GO:0060147)3.25500175
57regulation of gene silencing by miRNA (GO:0060964)3.25500175
58ribosome biogenesis (GO:0042254)3.23973964
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.23708174
60mitotic G1 DNA damage checkpoint (GO:0031571)3.21507378
61macromolecular complex disassembly (GO:0032984)3.21177782
62ribonucleoprotein complex biogenesis (GO:0022613)3.20330939
63mitotic sister chromatid segregation (GO:0000070)3.19804463
643-UTR-mediated mRNA stabilization (GO:0070935)3.19151774
65protein insertion into membrane (GO:0051205)3.18644228
66apoptotic process involved in development (GO:1902742)3.15834529
67intracellular estrogen receptor signaling pathway (GO:0030520)3.14693122
68protein localization to endoplasmic reticulum (GO:0070972)3.13662280
69regulation of glucose import in response to insulin stimulus (GO:2001273)3.13231580
70nuclear envelope disassembly (GO:0051081)3.10909623
71membrane disassembly (GO:0030397)3.10909623
72GDP-mannose metabolic process (GO:0019673)3.10620251
73telomere maintenance via semi-conservative replication (GO:0032201)3.10564246
74convergent extension (GO:0060026)3.09702252
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09574292
76DNA duplex unwinding (GO:0032508)3.06776631
77negative regulation of mRNA metabolic process (GO:1903312)3.06696881
78cytoskeletal anchoring at plasma membrane (GO:0007016)3.05982400
79basement membrane organization (GO:0071711)3.02879058
80mRNA stabilization (GO:0048255)3.02173827
81RNA stabilization (GO:0043489)3.02173827
82establishment of apical/basal cell polarity (GO:0035089)3.02063910
83mitotic chromosome condensation (GO:0007076)3.02040500
84DNA geometric change (GO:0032392)3.01279657
85modulation by virus of host process (GO:0019054)3.00450669
86IMP biosynthetic process (GO:0006188)3.00148172
87regulation of chromatin binding (GO:0035561)3.00128628
88lymph vessel development (GO:0001945)2.99354749
89ribosomal large subunit biogenesis (GO:0042273)2.98622287
90nucleobase biosynthetic process (GO:0046112)2.98320681
91tooth mineralization (GO:0034505)2.97404379
92barbed-end actin filament capping (GO:0051016)2.95988277
93cellular protein complex localization (GO:0034629)2.95365627
94peptidyl-lysine dimethylation (GO:0018027)2.95201077
95regulation of NFAT protein import into nucleus (GO:0051532)2.94072707
96nuclear-transcribed mRNA catabolic process (GO:0000956)2.93928740
97paraxial mesoderm development (GO:0048339)2.93847840
98folic acid metabolic process (GO:0046655)2.92230069
99vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.91858244
100endothelial cell chemotaxis (GO:0035767)2.90600332
101DNA replication checkpoint (GO:0000076)2.89852729
102positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.88421499
103sister chromatid segregation (GO:0000819)2.88062078
104pentose-phosphate shunt (GO:0006098)2.87609490
105dosage compensation (GO:0007549)2.87349355
106cochlea morphogenesis (GO:0090103)2.87283722
107positive regulation of protein dephosphorylation (GO:0035307)2.86705141
108activation of Rac GTPase activity (GO:0032863)2.86416228
109modulation by symbiont of host cellular process (GO:0044068)2.85667473
110protein-DNA complex disassembly (GO:0032986)2.85569232
111nucleosome disassembly (GO:0006337)2.85569232
112positive regulation of histone deacetylation (GO:0031065)2.84434196
113rRNA transcription (GO:0009303)2.82834129
114Golgi transport vesicle coating (GO:0048200)2.82165754
115COPI coating of Golgi vesicle (GO:0048205)2.82165754
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.81291735
117spliceosomal snRNP assembly (GO:0000387)2.81024678
118ncRNA 3-end processing (GO:0043628)2.79267646
119activation of MAPKKK activity (GO:0000185)2.78710925
120cell migration involved in heart development (GO:0060973)2.78243611
121RNA catabolic process (GO:0006401)2.78005254
122chromatin assembly (GO:0031497)2.76699528
123regulation of apoptotic process involved in morphogenesis (GO:1902337)2.76609563
124trophectodermal cell differentiation (GO:0001829)2.75783078
125mRNA catabolic process (GO:0006402)2.75660184
126adhesion of symbiont to host (GO:0044406)2.74137491
127transcription from mitochondrial promoter (GO:0006390)2.73375790
128cell-substrate junction assembly (GO:0007044)2.72837727
129positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72592009
130mitotic G1/S transition checkpoint (GO:0044819)2.72368169
131proline biosynthetic process (GO:0006561)2.71274818
132negative regulation of catenin import into nucleus (GO:0035414)2.71129833
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.70605450
134mRNA splicing, via spliceosome (GO:0000398)2.70605450
135mitotic metaphase plate congression (GO:0007080)2.70470386
136IMP metabolic process (GO:0046040)2.70014864
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68947116
138proline metabolic process (GO:0006560)2.68702412
139cell-cell junction maintenance (GO:0045217)2.68242512
140RNA splicing, via transesterification reactions (GO:0000375)2.68197039
141apoptotic process involved in morphogenesis (GO:0060561)2.67931904
142modulation by virus of host morphology or physiology (GO:0019048)2.67531880
143translation (GO:0006412)2.65448491
144positive regulation of synapse maturation (GO:0090129)2.64348096
145protein complex localization (GO:0031503)2.64331430
146regulation of protein heterodimerization activity (GO:0043497)2.63623326
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.63339577
148nuclear envelope organization (GO:0006998)2.62636415
149polarized epithelial cell differentiation (GO:0030859)2.62453352
150retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61986094
151regulation of fatty acid beta-oxidation (GO:0031998)2.61618255
152negative regulation of fatty acid transport (GO:2000192)2.61012565
153pteridine-containing compound biosynthetic process (GO:0042559)2.60781395
154termination of RNA polymerase II transcription (GO:0006369)2.60592847
155rRNA processing (GO:0006364)2.59871639
156stress fiber assembly (GO:0043149)2.59384242
157atrioventricular valve morphogenesis (GO:0003181)2.58735374
158mammary gland epithelial cell differentiation (GO:0060644)2.55345740
159neural tube development (GO:0021915)2.52610627
160protein targeting to plasma membrane (GO:0072661)2.51406228
161positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51398520
162virion attachment to host cell (GO:0019062)2.50116360
163adhesion of symbiont to host cell (GO:0044650)2.50116360
164synaptic vesicle docking involved in exocytosis (GO:0016081)2.50092432
165positive regulation of myotube differentiation (GO:0010831)2.48782753
166osteoblast development (GO:0002076)2.47970267
167negative regulation of viral release from host cell (GO:1902187)2.47117178
168adenosine receptor signaling pathway (GO:0001973)2.47091037
169skeletal muscle organ development (GO:0060538)2.46795991
170cell migration in hindbrain (GO:0021535)2.46428043
171mitotic nuclear envelope reassembly (GO:0007084)2.45343218
172nuclear envelope reassembly (GO:0031468)2.45343218
173diaphragm development (GO:0060539)2.41392609
174positive regulation of blood vessel endothelial cell migration (GO:0043536)2.39990991
175mitochondrial fusion (GO:0008053)2.39806982

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.17685746
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79059959
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.41010039
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.22131560
5MYC_22102868_ChIP-Seq_BL_Human2.82227520
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68524135
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50802536
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.38207362
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32088536
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26637996
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15015607
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11227679
13XRN2_22483619_ChIP-Seq_HELA_Human2.07091372
14VDR_21846776_ChIP-Seq_THP-1_Human2.04034424
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.01406995
16E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95196315
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92955036
18ERG_21242973_ChIP-ChIP_JURKAT_Human1.87558687
19KDM2B_26808549_Chip-Seq_K562_Human1.86065898
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.82928506
21* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80710946
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77083368
23UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.69836868
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68798487
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68455437
26* SA1_27219007_Chip-Seq_ERYTHROID_Human1.68376599
27* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65691842
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.65386477
29CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64744017
30* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64450923
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62528883
32ZNF263_19887448_ChIP-Seq_K562_Human1.61868686
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61158103
34LXR_22292898_ChIP-Seq_THP-1_Human1.60854610
35* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57705627
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57373723
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57048318
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55164879
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53848800
40* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53794115
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53225431
42SMC4_20622854_ChIP-Seq_HELA_Human1.52934097
43CIITA_25753668_ChIP-Seq_RAJI_Human1.51454427
44* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50734848
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50172751
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49837418
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48608896
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48407745
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47891323
50CREB1_26743006_Chip-Seq_LNCaP_Human1.45716518
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44221656
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43866086
53* GABP_19822575_ChIP-Seq_HepG2_Human1.42842522
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41766995
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41766995
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41766995
57TCF7_22412390_ChIP-Seq_EML_Mouse1.41748382
58KDM2B_26808549_Chip-Seq_DND41_Human1.41572873
59* CTCF_27219007_Chip-Seq_Bcells_Human1.41095131
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.39299193
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39114896
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38567677
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38000613
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37856235
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37286876
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37257378
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.36206748
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34370871
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34048589
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33777119
71TTF2_22483619_ChIP-Seq_HELA_Human1.33097453
72AR_21909140_ChIP-Seq_LNCAP_Human1.32749765
73KDM5A_27292631_Chip-Seq_BREAST_Human1.32415245
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32252940
75VDR_24763502_ChIP-Seq_THP-1_Human1.31832462
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31493037
77TP53_22127205_ChIP-Seq_IMR90_Human1.30810772
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30562527
79DCP1A_22483619_ChIP-Seq_HELA_Human1.30549849
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29793627
81BCOR_27268052_Chip-Seq_Bcells_Human1.29363307
82RACK7_27058665_Chip-Seq_MCF-7_Human1.29303276
83MAF_26560356_Chip-Seq_TH2_Human1.29226717
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26592350
85BCL6_27268052_Chip-Seq_Bcells_Human1.26460655
86ATF3_27146783_Chip-Seq_COLON_Human1.25854679
87* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25350194
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25186192
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25062169
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.24379150
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22332371
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22204347
93* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21708637
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21270984
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19122065
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16099680
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15794893
98* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15146119
99* P68_20966046_ChIP-Seq_HELA_Human1.15097405
100CTCF_26484167_Chip-Seq_Bcells_Mouse1.14033904
101RARA_24833708_ChIP-Seq_LIVER_Mouse1.13802645
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.13765415
103MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13695979
104SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13365299
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13228909
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.12703627
107PHF8_20622854_ChIP-Seq_HELA_Human1.11742445
108FOXP3_21729870_ChIP-Seq_TREG_Human1.10700296
109FOXP1_21924763_ChIP-Seq_HESCs_Human1.10339354
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10283377
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.10233393
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.10210771
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.09900527
114* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09215318
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08525657
116CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07907947
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07737673
118GABP_17652178_ChIP-ChIP_JURKAT_Human1.06783071
119UTX_26944678_Chip-Seq_JUKART_Human1.06518447
120TP63_17297297_ChIP-ChIP_HaCaT_Human1.06469660
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06307505
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06188546
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05113567
124CTCF_21964334_Chip-Seq_Bcells_Human1.05068392
125E2F1_20622854_ChIP-Seq_HELA_Human1.04240305
126* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04061688
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.03961623
128ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03317067
129* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03173953
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02820619
131VDR_23849224_ChIP-Seq_CD4+_Human1.02651106
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.02537408
133MAF_26560356_Chip-Seq_TH1_Human1.01651400
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01411311
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00457033
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00442803
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00166686
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99909548
139NCOR1_26117541_ChIP-Seq_K562_Human0.99867834
140TP53_20018659_ChIP-ChIP_R1E_Mouse0.99580083
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99353272
142PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99345845
143* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99221965
144ETS1_21867929_ChIP-Seq_TH2_Mouse0.97966637
145* YY1_22570637_ChIP-Seq_MALME-3M_Human0.97818132
146* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97643657
147KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97254718
148TFEB_21752829_ChIP-Seq_HELA_Human0.96497708
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96148045
150POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95529424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.03020421
2MP0004957_abnormal_blastocyst_morpholog3.49191650
3MP0010030_abnormal_orbit_morphology3.29270090
4MP0003693_abnormal_embryo_hatching3.26716063
5MP0010352_gastrointestinal_tract_polyps3.12544358
6MP0005058_abnormal_lysosome_morphology3.01848705
7MP0003111_abnormal_nucleus_morphology3.01687557
8MP0005451_abnormal_body_composition2.69836350
9MP0003077_abnormal_cell_cycle2.50015134
10MP0001730_embryonic_growth_arrest2.39659731
11MP0010094_abnormal_chromosome_stability2.27803781
12MP0003123_paternal_imprinting2.22853547
13MP0000751_myopathy2.13196804
14MP0000003_abnormal_adipose_tissue2.08120715
15MP0009278_abnormal_bone_marrow1.97783832
16MP0000350_abnormal_cell_proliferation1.97201435
17MP0002653_abnormal_ependyma_morphology1.97181726
18MP0005076_abnormal_cell_differentiation1.89040750
19MP0001672_abnormal_embryogenesis/_devel1.89005605
20MP0005380_embryogenesis_phenotype1.89005605
21MP0001849_ear_inflammation1.86287510
22MP0004197_abnormal_fetal_growth/weight/1.85802499
23MP0002877_abnormal_melanocyte_morpholog1.85222113
24MP0001697_abnormal_embryo_size1.83135223
25MP0002084_abnormal_developmental_patter1.78952042
26MP0005409_darkened_coat_color1.78905248
27MP0003984_embryonic_growth_retardation1.77956009
28MP0002085_abnormal_embryonic_tissue1.77714882
29MP0008007_abnormal_cellular_replicative1.77543359
30MP0002088_abnormal_embryonic_growth/wei1.76350119
31MP0003283_abnormal_digestive_organ1.75639279
32MP0003453_abnormal_keratinocyte_physiol1.75253068
33MP0008932_abnormal_embryonic_tissue1.69075771
34MP0002396_abnormal_hematopoietic_system1.68583008
35MP0000537_abnormal_urethra_morphology1.67450473
36MP0009053_abnormal_anal_canal1.67351554
37* MP0002080_prenatal_lethality1.67169423
38MP0002086_abnormal_extraembryonic_tissu1.67106965
39MP0003329_amyloid_beta_deposits1.66592212
40MP0008057_abnormal_DNA_replication1.66483419
41MP0003119_abnormal_digestive_system1.64302037
42MP0009379_abnormal_foot_pigmentation1.63469776
43MP0003279_aneurysm1.60076299
44MP0005375_adipose_tissue_phenotype1.53314847
45MP0005666_abnormal_adipose_tissue1.42671233
46MP0004233_abnormal_muscle_weight1.42138141
47MP0001348_abnormal_lacrimal_gland1.41048289
48MP0008260_abnormal_autophagy1.40179314
49MP0003566_abnormal_cell_adhesion1.40057863
50MP0000681_abnormal_thyroid_gland1.39956146
51MP0001661_extended_life_span1.38909323
52MP0003567_abnormal_fetal_cardiomyocyte1.38718423
53MP0004510_myositis1.38253648
54MP0000733_abnormal_muscle_development1.35689142
55MP0005670_abnormal_white_adipose1.35126708
56MP0008961_abnormal_basal_metabolism1.35056931
57MP0000750_abnormal_muscle_regeneration1.31967569
58MP0004272_abnormal_basement_membrane1.31692951
59MP0009840_abnormal_foam_cell1.30325397
60MP0005023_abnormal_wound_healing1.29161845
61MP0000490_abnormal_crypts_of1.27524720
62MP0003890_abnormal_embryonic-extraembry1.27226258
63MP0001958_emphysema1.25445039
64MP0002249_abnormal_larynx_morphology1.24820132
65MP0002932_abnormal_joint_morphology1.23709211
66MP0001346_abnormal_lacrimal_gland1.21268154
67MP0002269_muscular_atrophy1.20811373
68MP0000313_abnormal_cell_death1.19693622
69MP0000428_abnormal_craniofacial_morphol1.19603387
70MP0001293_anophthalmia1.18536431
71MP0003115_abnormal_respiratory_system1.18393095
72MP0003091_abnormal_cell_migration1.17634493
73MP0005397_hematopoietic_system_phenotyp1.17405072
74MP0001545_abnormal_hematopoietic_system1.17405072
75MP0009672_abnormal_birth_weight1.16279751
76MP0002089_abnormal_postnatal_growth/wei1.16012905
77MP0004808_abnormal_hematopoietic_stem1.15343445
78MP0010307_abnormal_tumor_latency1.10619662
79MP0004133_heterotaxia1.10362803
80MP0008770_decreased_survivor_rate1.09699504
81MP0000767_abnormal_smooth_muscle1.09551763
82MP0003172_abnormal_lysosome_physiology1.09383081
83MP0000678_abnormal_parathyroid_gland1.08966281
84MP0000013_abnormal_adipose_tissue1.08164122
85MP0004859_abnormal_synaptic_plasticity1.07610936
86MP0002111_abnormal_tail_morphology1.07490379
87MP0002019_abnormal_tumor_incidence1.07361987
88MP0004185_abnormal_adipocyte_glucose1.00699883
89MP0010630_abnormal_cardiac_muscle1.00303554
90MP0005623_abnormal_meninges_morphology0.99196489
91MP0000049_abnormal_middle_ear0.98296240
92MP0005508_abnormal_skeleton_morphology0.97850335
93MP0000566_synostosis0.97151609
94MP0003221_abnormal_cardiomyocyte_apopto0.96105634
95MP0003303_peritoneal_inflammation0.95676281
96MP0004087_abnormal_muscle_fiber0.95449948
97MP0000358_abnormal_cell_content/0.95132696
98MP0002092_abnormal_eye_morphology0.94176088
99MP0003942_abnormal_urinary_system0.93625306
100MP0004264_abnormal_extraembryonic_tissu0.93617601
101MP0003634_abnormal_glial_cell0.92046387
102MP0002925_abnormal_cardiovascular_devel0.90178978
103MP0009703_decreased_birth_body0.89369451
104MP0008058_abnormal_DNA_repair0.88896766
105MP0009250_abnormal_appendicular_skeleto0.87933546
106MP0002060_abnormal_skin_morphology0.87869707
107MP0009384_cardiac_valve_regurgitation0.87749672
108MP0004858_abnormal_nervous_system0.86845911
109MP0004130_abnormal_muscle_cell0.85081821
110MP0000759_abnormal_skeletal_muscle0.84567546
111MP0000762_abnormal_tongue_morphology0.84268051
112MP0000534_abnormal_ureter_morphology0.84109864
113MP0003935_abnormal_craniofacial_develop0.83941430
114MP0000266_abnormal_heart_morphology0.82539359
115MP0005503_abnormal_tendon_morphology0.81883684
116MP0004084_abnormal_cardiac_muscle0.81154844
117MP0000747_muscle_weakness0.80582337
118MP0005501_abnormal_skin_physiology0.80231807
119MP0008438_abnormal_cutaneous_collagen0.79673853
120MP0002697_abnormal_eye_size0.79262731
121MP0000703_abnormal_thymus_morphology0.79180670
122MP0005330_cardiomyopathy0.79164107
123MP0003806_abnormal_nucleotide_metabolis0.79113434
124MP0002116_abnormal_craniofacial_bone0.79050501
125MP0002114_abnormal_axial_skeleton0.77603014
126MP0000467_abnormal_esophagus_morphology0.77067894
127MP0000858_altered_metastatic_potential0.76763305
128MP0002282_abnormal_trachea_morphology0.76517395
129MP0000477_abnormal_intestine_morphology0.76370365
130MP0002796_impaired_skin_barrier0.76269464
131MP0009931_abnormal_skin_appearance0.75840749
132MP0005257_abnormal_intraocular_pressure0.75834867
133MP0003385_abnormal_body_wall0.75633755
134MP0003122_maternal_imprinting0.75217051
135MP0002970_abnormal_white_adipose0.75141832
136MP0002896_abnormal_bone_mineralization0.74852416
137MP0002234_abnormal_pharynx_morphology0.73832461
138MP0009333_abnormal_splenocyte_physiolog0.73773570
139MP0000604_amyloidosis0.73623014
140MP0003121_genomic_imprinting0.71516632
141MP0001915_intracranial_hemorrhage0.70985927
142MP0005394_taste/olfaction_phenotype0.70700099
143MP0004947_skin_inflammation0.68965119
144MP0000749_muscle_degeneration0.67443350
145MP0010368_abnormal_lymphatic_system0.65098461
146MP0000462_abnormal_digestive_system0.64323746
147MP0005621_abnormal_cell_physiology0.63430300

Predicted human phenotypes

RankGene SetZ-score
1Multiple enchondromatosis (HP:0005701)3.96005512
2Protrusio acetabuli (HP:0003179)3.51452808
3Ependymoma (HP:0002888)3.47095220
4Turricephaly (HP:0000262)3.46219072
5Abnormality of cells of the erythroid lineage (HP:0012130)3.39652864
6Hyperacusis (HP:0010780)3.36883166
7Selective tooth agenesis (HP:0001592)3.36746082
8Renal duplication (HP:0000075)3.33687817
9Abnormal number of erythroid precursors (HP:0012131)3.09467680
10Angiofibromas (HP:0010615)3.04290303
11Adenoma sebaceum (HP:0009720)3.04290303
12Broad distal phalanx of finger (HP:0009836)2.99856109
13Stridor (HP:0010307)2.97358186
14Trismus (HP:0000211)2.95403306
15Achilles tendon contracture (HP:0001771)2.88844553
16Abnormality of the lower motor neuron (HP:0002366)2.87299235
17Obstructive sleep apnea (HP:0002870)2.84620473
18Distal lower limb amyotrophy (HP:0008944)2.76937847
19Abnormality of the Achilles tendon (HP:0005109)2.70533741
20Colon cancer (HP:0003003)2.59192165
21Hand muscle atrophy (HP:0009130)2.58441636
22Spinal rigidity (HP:0003306)2.56645636
23Distal upper limb amyotrophy (HP:0007149)2.51830052
24Upper limb amyotrophy (HP:0009129)2.51830052
25Difficulty climbing stairs (HP:0003551)2.51119697
26Genu recurvatum (HP:0002816)2.50091409
27Vertebral compression fractures (HP:0002953)2.49887313
28Broad face (HP:0000283)2.49777334
29Progressive muscle weakness (HP:0003323)2.48581727
30Disproportionate tall stature (HP:0001519)2.48026794
31Rib fusion (HP:0000902)2.47165608
32Neoplasm of striated muscle (HP:0009728)2.47040356
33Abnormality of the astrocytes (HP:0100707)2.46120011
34Astrocytoma (HP:0009592)2.46120011
35Thin bony cortex (HP:0002753)2.43099757
36Shallow orbits (HP:0000586)2.40425988
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.36923804
38Reticulocytopenia (HP:0001896)2.35484170
39Increased variability in muscle fiber diameter (HP:0003557)2.33760233
40Cerebral aneurysm (HP:0004944)2.33157445
41Long palpebral fissure (HP:0000637)2.33121868
42Basal cell carcinoma (HP:0002671)2.33003203
43Rhabdomyosarcoma (HP:0002859)2.32444997
44Increased nuchal translucency (HP:0010880)2.30317822
45Fragile skin (HP:0001030)2.30031476
46Thin ribs (HP:0000883)2.29215246
47Mitral regurgitation (HP:0001653)2.27643012
48Ulnar bowing (HP:0003031)2.27458062
49Increased connective tissue (HP:0009025)2.23167870
50Insomnia (HP:0100785)2.22146624
51Biconcave vertebral bodies (HP:0004586)2.21929071
52Truncus arteriosus (HP:0001660)2.17723124
53Annular pancreas (HP:0001734)2.17233668
54Distal lower limb muscle weakness (HP:0009053)2.15108542
55Spastic diplegia (HP:0001264)2.14961648
56Testicular atrophy (HP:0000029)2.14357069
57Ankle contracture (HP:0006466)2.14302726
58Atresia of the external auditory canal (HP:0000413)2.14068954
59Missing ribs (HP:0000921)2.13623884
60Lower limb amyotrophy (HP:0007210)2.13552857
61Skin tags (HP:0010609)2.12256246
62Medulloblastoma (HP:0002885)2.10903988
63Rectal prolapse (HP:0002035)2.10052242
64Elfin facies (HP:0004428)2.09993370
65Microretrognathia (HP:0000308)2.09399395
66Short 4th metacarpal (HP:0010044)2.09129856
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09129856
68Fibroma (HP:0010614)2.07805424
69Abnormality of the 4th metacarpal (HP:0010012)2.06238158
70Renovascular hypertension (HP:0100817)2.06219817
71Preauricular skin tag (HP:0000384)2.05925069
72Abnormal number of incisors (HP:0011064)2.05612220
73Patellar dislocation (HP:0002999)2.04502638
74Overriding aorta (HP:0002623)2.02330929
75Mildly elevated creatine phosphokinase (HP:0008180)2.01871773
76Abnormality of the calcaneus (HP:0008364)2.00837816
77Hallux valgus (HP:0001822)2.00826393
78Oral leukoplakia (HP:0002745)2.00756076
79Bowel diverticulosis (HP:0005222)1.99983182
80Calcaneovalgus deformity (HP:0001848)1.99137783
81Abnormality of skeletal muscle fiber size (HP:0012084)1.98983642
82Abnormal cartilage morphology (HP:0002763)1.97468125
83Abnormality of the thoracic spine (HP:0100711)1.97206699
84Deviation of the hallux (HP:0010051)1.96614325
85Blue sclerae (HP:0000592)1.94930504
86Pseudobulbar signs (HP:0002200)1.92261635
87Degeneration of anterior horn cells (HP:0002398)1.91906906
88Abnormality of the anterior horn cell (HP:0006802)1.91906906
89Fibrous tissue neoplasm (HP:0012316)1.91906184
90Abnormality of the aortic arch (HP:0012303)1.91374923
91Lymphangioma (HP:0100764)1.91004554
92Partial duplication of the phalanx of hand (HP:0009999)1.87040623
93Bladder diverticulum (HP:0000015)1.86526308
94Type 1 muscle fiber predominance (HP:0003803)1.85698787
95Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85692123
96Coronal craniosynostosis (HP:0004440)1.85444026
97Intestinal polyp (HP:0005266)1.85305061
98Back pain (HP:0003418)1.84429005
99Deformed tarsal bones (HP:0008119)1.83476502
100Patellar aplasia (HP:0006443)1.82719393
101Hyperparathyroidism (HP:0000843)1.82007844
102Short 5th finger (HP:0009237)1.80157248
103Elbow flexion contracture (HP:0002987)1.79878988
104Bulbar palsy (HP:0001283)1.79641078
105Macrocytic anemia (HP:0001972)1.79611550
106Abnormality of the phalanges of the hallux (HP:0010057)1.78851006
107Aplasia/Hypoplasia of the patella (HP:0006498)1.78712661
108Increased cerebral lipofuscin (HP:0011813)1.77414571
109High pitched voice (HP:0001620)1.75677994
110Abnormality of the distal phalanx of the thumb (HP:0009617)1.75521252
111Premature rupture of membranes (HP:0001788)1.75497918
112Increased neuronal autofluorescent lipopigment (HP:0002074)1.75279368
113Hypercortisolism (HP:0001578)1.75139763
114Ragged-red muscle fibers (HP:0003200)1.74869236
115Cervical subluxation (HP:0003308)1.74566781
116Atrophy/Degeneration involving motor neurons (HP:0007373)1.74246096
117Bilateral microphthalmos (HP:0007633)1.73575687
118Partial duplication of thumb phalanx (HP:0009944)1.72509368
119Joint stiffness (HP:0001387)1.72499812
120Premature skin wrinkling (HP:0100678)1.71822318
121Abnormality of the umbilical cord (HP:0010881)1.70800412
122Flat cornea (HP:0007720)1.70748546
123Round ear (HP:0100830)1.69573402
124Premature ovarian failure (HP:0008209)1.69009203
125Generalized amyotrophy (HP:0003700)1.68400038
126Abnormality of reticulocytes (HP:0004312)1.68298579
127Vertebral fusion (HP:0002948)1.68189122
128Slender long bone (HP:0003100)1.68106607
129Broad metatarsal (HP:0001783)1.68004265
130Pointed chin (HP:0000307)1.67749686
131Glioma (HP:0009733)1.67721407
132Breast hypoplasia (HP:0003187)1.67320680
133Hypercalcemia (HP:0003072)1.66864393
134Hypoventilation (HP:0002791)1.66787146
135Myoglobinuria (HP:0002913)1.66715490
136Intestinal polyposis (HP:0200008)1.66615499
137Polygenic inheritance (HP:0010982)1.66034650
138Ulnar deviation of the wrist (HP:0003049)1.65956111
139Hyperthyroidism (HP:0000836)1.65691362
140Bowed forearm bones (HP:0003956)1.65594712
141Bowing of the arm (HP:0006488)1.65594712
142Megalocornea (HP:0000485)1.65333953
143Mesangial abnormality (HP:0001966)1.64896676
144Short nail (HP:0001799)1.64485033
145Broad palm (HP:0001169)1.64390577
146Dislocated radial head (HP:0003083)1.64212527
147Hemorrhage of the eye (HP:0011885)1.63940882
148Mitral valve prolapse (HP:0001634)1.63504216
149Myopathic facies (HP:0002058)1.63483659
150Pallor (HP:0000980)1.63337119
151Congenital glaucoma (HP:0001087)1.62987797
152Exercise-induced muscle cramps (HP:0003710)1.62883473
153Increased density of long bones (HP:0006392)1.62629432
154Broad thumb (HP:0011304)1.62606645
155Arnold-Chiari malformation (HP:0002308)1.62575015
156Easy fatigability (HP:0003388)1.60910191
157Thoracic kyphosis (HP:0002942)1.60042828
158Flared metaphyses (HP:0003015)1.58783441
159Bowel incontinence (HP:0002607)1.58674701
160Abnormality of the distal phalanges of the toes (HP:0010182)1.58416047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.62714110
2SMG14.03845573
3MAP3K103.65978696
4PKN23.57010616
5EEF2K3.33867593
6IRAK33.06848399
7PRPF4B2.65163018
8BUB12.45878518
9ERN12.45664215
10CDK122.44296869
11NEK22.35604735
12CDC72.25442846
13ICK2.05102194
14NME21.95713252
15NEK11.94874224
16PAK41.77824778
17WEE11.76508939
18SCYL21.76015980
19TESK21.65385399
20TTK1.56088082
21MAP3K111.47977593
22LRRK21.41845668
23RPS6KB21.41138482
24ARAF1.40852321
25TYRO31.37075524
26LATS21.36918306
27CDK41.36784240
28TTN1.36760190
29CDK71.36657388
30RPS6KA41.35662820
31GRK61.35087856
32PDGFRA1.34165663
33DYRK31.32591517
34MAP2K31.29979816
35ALK1.25647691
36TAOK11.22531409
37BRAF1.21595261
38MAP3K81.19894948
39BCKDK1.18225103
40DDR21.16525253
41ILK1.14916041
42RIPK11.14821854
43RPS6KA21.13073953
44STK101.10694019
45PRKD31.09193569
46IRAK21.06958481
47MTOR1.06805282
48RPS6KL11.05152159
49BMX1.04603198
50PLK11.04268042
51TESK10.98559511
52MAPKAPK30.97892405
53PASK0.97835860
54PTK60.97138364
55MAP4K10.95438353
56MARK20.93899041
57EPHA20.92313985
58PDPK10.89777140
59FLT30.88961320
60RPS6KA60.85376132
61KDR0.85316133
62LMTK20.84008478
63CDC42BPA0.82555515
64AURKB0.81696133
65PAK20.78488364
66CAMK1D0.78343532
67NTRK10.77777569
68CDK60.76814240
69CDK190.75291935
70DYRK1B0.75117103
71AKT20.73775333
72SIK10.73318634
73FGFR40.72985839
74TGFBR10.72744969
75PAK10.70451039
76CHEK10.69389980
77TAOK20.68918645
78ATR0.64583182
79CHEK20.63925205
80CDK20.63152149
81ABL20.62802050
82CDK80.62278860
83MAPK120.62224101
84BRSK10.60793542
85CAMKK10.60382970
86MAP2K60.59554383
87* AURKA0.58964882
88MAP2K20.58050296
89MAP3K10.58002253
90MAP3K130.57902210
91EPHB20.57348337
92MAPK110.56611337
93TSSK60.56529433
94VRK20.54671712
95PIM20.53013234
96MATK0.51484988
97MOS0.50217096
98KSR20.49478464
99RPS6KA10.48782335
100CSF1R0.48580815
101PTK20.48220515
102EIF2AK10.46872481
103TBK10.45969671
104FGFR10.45657829
105UHMK10.45060630
106PRKG20.44549762
107MAP3K70.43735526
108DMPK0.43162595
109PHKG10.42737427
110PHKG20.42737427
111DAPK10.42347424
112MST1R0.41936855
113ZAP700.40704549
114PRKCI0.40055453
115CSNK1E0.39649651
116CAMK1G0.38769561
117PRKD20.38694082
118PIM10.38246645
119CDK11A0.37574350
120CSNK2A20.35320638
121TLK10.35272689
122MAP3K30.35006746
123MAPK40.34921727
124SRPK10.34564778
125PAK60.33191326
126SIK20.32838271
127DAPK30.32090227
128HIPK20.32040933
129PDK10.31991330
130MAPK150.31969209
131PDK30.31790426
132PDK40.31790426
133CDK180.31356913
134STK40.30918316
135CDK150.29991070
136RPS6KC10.29946590

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.10728378
2Ribosome_Homo sapiens_hsa030103.69019394
3Mismatch repair_Homo sapiens_hsa034303.23174591
4Spliceosome_Homo sapiens_hsa030402.97249491
5RNA transport_Homo sapiens_hsa030132.85340669
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65600288
7Base excision repair_Homo sapiens_hsa034102.57699547
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.54298379
9Other glycan degradation_Homo sapiens_hsa005112.39059804
10One carbon pool by folate_Homo sapiens_hsa006702.25094098
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23371741
12Sulfur relay system_Homo sapiens_hsa041222.11598298
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10123257
14Cell cycle_Homo sapiens_hsa041102.05528333
15mRNA surveillance pathway_Homo sapiens_hsa030151.89272865
16Biosynthesis of amino acids_Homo sapiens_hsa012301.85311660
17Nucleotide excision repair_Homo sapiens_hsa034201.81868613
18Prion diseases_Homo sapiens_hsa050201.80016445
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.74674639
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67209885
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63398429
22Bladder cancer_Homo sapiens_hsa052191.57534674
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.54961351
24Proteasome_Homo sapiens_hsa030501.54227299
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.50241730
26Homologous recombination_Homo sapiens_hsa034401.44710097
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44252801
28Carbon metabolism_Homo sapiens_hsa012001.43990593
29Pyrimidine metabolism_Homo sapiens_hsa002401.39767379
30Thyroid cancer_Homo sapiens_hsa052161.37538089
31Notch signaling pathway_Homo sapiens_hsa043301.35328862
32RNA polymerase_Homo sapiens_hsa030201.33560335
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.32883772
34Basal cell carcinoma_Homo sapiens_hsa052171.27910067
35mTOR signaling pathway_Homo sapiens_hsa041501.26181911
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25339894
37Chronic myeloid leukemia_Homo sapiens_hsa052201.22343360
38p53 signaling pathway_Homo sapiens_hsa041151.19636451
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18468696
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14317874
41Pentose phosphate pathway_Homo sapiens_hsa000301.12294949
42Hippo signaling pathway_Homo sapiens_hsa043901.11602494
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.11393990
44Selenocompound metabolism_Homo sapiens_hsa004501.09858360
45Fructose and mannose metabolism_Homo sapiens_hsa000511.06787048
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03729938
47ErbB signaling pathway_Homo sapiens_hsa040121.02417933
48Hedgehog signaling pathway_Homo sapiens_hsa043401.00782977
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00402463
50VEGF signaling pathway_Homo sapiens_hsa043700.96097517
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95887132
52GnRH signaling pathway_Homo sapiens_hsa049120.95817194
53HTLV-I infection_Homo sapiens_hsa051660.95059374
54RNA degradation_Homo sapiens_hsa030180.94248279
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93406584
56Small cell lung cancer_Homo sapiens_hsa052220.91748628
57Oocyte meiosis_Homo sapiens_hsa041140.90888565
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.90315048
59Non-small cell lung cancer_Homo sapiens_hsa052230.90222396
60Galactose metabolism_Homo sapiens_hsa000520.89810674
61Acute myeloid leukemia_Homo sapiens_hsa052210.88287464
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.87040013
63MicroRNAs in cancer_Homo sapiens_hsa052060.85718417
64Renal cell carcinoma_Homo sapiens_hsa052110.85361656
65Lysosome_Homo sapiens_hsa041420.85133668
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81484129
67B cell receptor signaling pathway_Homo sapiens_hsa046620.79280376
68Estrogen signaling pathway_Homo sapiens_hsa049150.78675604
69Melanogenesis_Homo sapiens_hsa049160.77765444
70Lysine degradation_Homo sapiens_hsa003100.77747656
71Proteoglycans in cancer_Homo sapiens_hsa052050.77553106
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74596106
73Synaptic vesicle cycle_Homo sapiens_hsa047210.73329230
74Colorectal cancer_Homo sapiens_hsa052100.72601018
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71803507
76Vibrio cholerae infection_Homo sapiens_hsa051100.71216827
77Folate biosynthesis_Homo sapiens_hsa007900.70801472
78Endocytosis_Homo sapiens_hsa041440.70556528
79Melanoma_Homo sapiens_hsa052180.70283781
80Viral carcinogenesis_Homo sapiens_hsa052030.66903437
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66538191
82ECM-receptor interaction_Homo sapiens_hsa045120.66075389
83Prostate cancer_Homo sapiens_hsa052150.65976742
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.65526522
85Endometrial cancer_Homo sapiens_hsa052130.64986955
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64806731
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64330243
88Vitamin B6 metabolism_Homo sapiens_hsa007500.64218769
89Epstein-Barr virus infection_Homo sapiens_hsa051690.63709287
90AMPK signaling pathway_Homo sapiens_hsa041520.63650096
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62880332
92Nitrogen metabolism_Homo sapiens_hsa009100.62341721
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.61623354
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59101553
95HIF-1 signaling pathway_Homo sapiens_hsa040660.56310211
96Adherens junction_Homo sapiens_hsa045200.56230144
97Prolactin signaling pathway_Homo sapiens_hsa049170.56156146
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.55827352
99Hepatitis B_Homo sapiens_hsa051610.55510884
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54421131
101Choline metabolism in cancer_Homo sapiens_hsa052310.53801432
102MAPK signaling pathway_Homo sapiens_hsa040100.52624633
103Arginine biosynthesis_Homo sapiens_hsa002200.52532405
104Antigen processing and presentation_Homo sapiens_hsa046120.51823254
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51709340
106Long-term potentiation_Homo sapiens_hsa047200.51693095
107Hepatitis C_Homo sapiens_hsa051600.51649505
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50615387
109Insulin signaling pathway_Homo sapiens_hsa049100.50400858
110Fanconi anemia pathway_Homo sapiens_hsa034600.49549324
111Tight junction_Homo sapiens_hsa045300.49236924
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49181966
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48294913
114Inositol phosphate metabolism_Homo sapiens_hsa005620.47416696
115Glioma_Homo sapiens_hsa052140.47321413
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46970306
117Axon guidance_Homo sapiens_hsa043600.46757138
118Pathways in cancer_Homo sapiens_hsa052000.46313066
119Shigellosis_Homo sapiens_hsa051310.46080646
120Focal adhesion_Homo sapiens_hsa045100.46005760
121Apoptosis_Homo sapiens_hsa042100.45968101
122Amoebiasis_Homo sapiens_hsa051460.45027818
123Dilated cardiomyopathy_Homo sapiens_hsa054140.44422985
124Herpes simplex infection_Homo sapiens_hsa051680.44351642
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44169894
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43575411
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39628237
128Pyruvate metabolism_Homo sapiens_hsa006200.39523276
129Arginine and proline metabolism_Homo sapiens_hsa003300.39090942
130Insulin resistance_Homo sapiens_hsa049310.38998609
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38981773
132Wnt signaling pathway_Homo sapiens_hsa043100.38857653
133N-Glycan biosynthesis_Homo sapiens_hsa005100.35093769
134Glutathione metabolism_Homo sapiens_hsa004800.34860328
135TGF-beta signaling pathway_Homo sapiens_hsa043500.34714645
136Purine metabolism_Homo sapiens_hsa002300.33323143
137Viral myocarditis_Homo sapiens_hsa054160.32093226
138Pancreatic cancer_Homo sapiens_hsa052120.31666115
139Glucagon signaling pathway_Homo sapiens_hsa049220.31163963

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