MBD3L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.85550770
2axonemal dynein complex assembly (GO:0070286)9.81964631
3spermatid development (GO:0007286)9.72402413
4epithelial cilium movement (GO:0003351)9.66416205
5cilium or flagellum-dependent cell motility (GO:0001539)9.37180043
6motile cilium assembly (GO:0044458)8.94645314
7regulation of cilium movement (GO:0003352)8.85981844
8cilium movement (GO:0003341)8.02549357
9single fertilization (GO:0007338)7.69207095
10sperm capacitation (GO:0048240)7.62413293
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.43908812
12male meiosis (GO:0007140)7.43691678
13synaptonemal complex organization (GO:0070193)7.23390104
14synaptonemal complex assembly (GO:0007130)7.18499933
15piRNA metabolic process (GO:0034587)6.98162380
16negative regulation of inclusion body assembly (GO:0090084)6.81675562
17spermatogenesis (GO:0007283)6.67275254
18male gamete generation (GO:0048232)6.64851321
19fertilization (GO:0009566)6.43207595
20microtubule depolymerization (GO:0007019)6.38992536
21organic cation transport (GO:0015695)6.38563306
22gamete generation (GO:0007276)6.11467611
23regulation of inclusion body assembly (GO:0090083)5.70914723
24calcium ion-dependent exocytosis (GO:0017156)5.53263024
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.44393186
26germ cell development (GO:0007281)5.38547421
27ventricular system development (GO:0021591)5.32952381
28cell recognition (GO:0008037)5.24829100
29microtubule severing (GO:0051013)5.21039249
30regulation of microtubule-based movement (GO:0060632)5.20727254
31spermatid nucleus differentiation (GO:0007289)5.19456671
32chromosome organization involved in meiosis (GO:0070192)4.94499240
33glycerol ether metabolic process (GO:0006662)4.92515134
34chromosome condensation (GO:0030261)4.91196036
35multicellular organismal reproductive process (GO:0048609)4.81336883
36male meiosis I (GO:0007141)4.73878664
37DNA packaging (GO:0006323)4.61360595
38ether metabolic process (GO:0018904)4.55369292
39DNA methylation involved in gamete generation (GO:0043046)4.50212031
40seminiferous tubule development (GO:0072520)4.45985633
41meiotic nuclear division (GO:0007126)4.26878640
42left/right pattern formation (GO:0060972)4.07904015
43protein polyglutamylation (GO:0018095)4.04501745
44chaperone-mediated protein complex assembly (GO:0051131)3.97970207
45multicellular organismal development (GO:0007275)3.88511311
46monoubiquitinated protein deubiquitination (GO:0035520)3.77077699
47meiosis I (GO:0007127)3.76428440
48single strand break repair (GO:0000012)3.70998269
49sexual reproduction (GO:0019953)3.69355661
50genitalia morphogenesis (GO:0035112)3.63816896
51protein K11-linked deubiquitination (GO:0035871)3.41113413
52sequestering of actin monomers (GO:0042989)3.38240469
53regulation of spindle checkpoint (GO:0090231)3.35761172
54microtubule polymerization or depolymerization (GO:0031109)3.25848821
55protein localization to cilium (GO:0061512)3.17859031
56glycolytic process (GO:0006096)3.15403037
57meiotic cell cycle (GO:0051321)3.13372724
58carnitine transport (GO:0015879)3.11713267
59amino-acid betaine transport (GO:0015838)3.11713267
60protein refolding (GO:0042026)3.08985731
61synapsis (GO:0007129)3.05818230
62nucleoside diphosphate phosphorylation (GO:0006165)3.02387519
63carnitine transmembrane transport (GO:1902603)2.97687111
64polyol catabolic process (GO:0046174)2.95355856
65nucleus organization (GO:0006997)2.95273538
66GTP biosynthetic process (GO:0006183)2.93070218
67positive regulation of macrophage activation (GO:0043032)2.92546259
68mitotic sister chromatid cohesion (GO:0007064)2.91721523
69interferon-gamma secretion (GO:0072643)2.83213360
70cilium organization (GO:0044782)2.82753310
71meiotic cell cycle process (GO:1903046)2.80078837
72alditol metabolic process (GO:0019400)2.80019640
73lactate metabolic process (GO:0006089)2.79376059
74intraciliary transport (GO:0042073)2.77678829
75microtubule-based movement (GO:0007018)2.76572655
76cellular component assembly involved in morphogenesis (GO:0010927)2.75263811
77negative regulation of organelle assembly (GO:1902116)2.71802441
78cilium assembly (GO:0042384)2.70017565
79cilium morphogenesis (GO:0060271)2.67671373
80peptidyl-glutamic acid modification (GO:0018200)2.62096551
81UTP biosynthetic process (GO:0006228)2.60707903
82RNA localization (GO:0006403)2.57453447
83axoneme assembly (GO:0035082)2.52745923
84gene silencing by RNA (GO:0031047)2.49604608
85calcium ion import (GO:0070509)2.48262248
86regulation of cilium assembly (GO:1902017)2.47070975
87RNA destabilization (GO:0050779)2.43698146
88polyamine biosynthetic process (GO:0006596)2.42924518
89chromatin silencing (GO:0006342)2.40137285
90sperm motility (GO:0030317)14.1563202
91fusion of sperm to egg plasma membrane (GO:0007342)13.6075465
92cell wall macromolecule metabolic process (GO:0044036)13.0406223
93cell wall macromolecule catabolic process (GO:0016998)13.0406223
94acrosome assembly (GO:0001675)12.8064347
95acrosome reaction (GO:0007340)12.0544498
96sperm-egg recognition (GO:0035036)12.0468642
97multicellular organism reproduction (GO:0032504)11.6160651
98binding of sperm to zona pellucida (GO:0007339)10.8213479
99cell-cell recognition (GO:0009988)10.7910141
100plasma membrane fusion (GO:0045026)10.3672261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.04598271
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.93356812
3EZH2_22144423_ChIP-Seq_EOC_Human4.14076231
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16083473
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.01471367
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84691018
7VDR_22108803_ChIP-Seq_LS180_Human2.45262300
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44956624
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23403734
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.14824364
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.14666899
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14089569
13ZNF274_21170338_ChIP-Seq_K562_Hela2.07945347
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.02640610
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00633740
16KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.97784773
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95001650
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92775594
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.79128528
20RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.70950270
21STAT1_17558387_ChIP-Seq_HELA_Human1.70758238
22ELK4_26923725_Chip-Seq_MESODERM_Mouse1.66585197
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.66101718
24* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63808244
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.60829605
26MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57350454
27SOX2_22085726_ChIP-Seq_NPCs_Mouse1.54934491
28GATA3_21867929_ChIP-Seq_CD8_Mouse1.53826656
29KAP1_22055183_ChIP-Seq_ESCs_Mouse1.53602701
30KDM2B_26808549_Chip-Seq_REH_Human1.51185328
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.47466826
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45243202
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.43526275
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.38102090
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37312611
36LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34366659
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.34035457
38FLI1_21867929_ChIP-Seq_TH2_Mouse1.33724719
39GATA3_21867929_ChIP-Seq_TH1_Mouse1.32844916
40* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31031074
41* CBP_20019798_ChIP-Seq_JUKART_Human1.31031074
42FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30225939
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28805272
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28436485
45P53_21459846_ChIP-Seq_SAOS-2_Human1.27618153
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27466313
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25314968
48REST_21632747_ChIP-Seq_MESCs_Mouse1.25214598
49GF1_26923725_Chip-Seq_HPCs_Mouse1.23885975
50* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20697638
51RNF2_27304074_Chip-Seq_NSC_Mouse1.20440287
52CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20048563
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.17994282
54RUNX1_26923725_Chip-Seq_HPCs_Mouse1.16983375
55SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15172724
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.15080093
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14493847
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14493847
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13747253
60CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12668331
61TAF15_26573619_Chip-Seq_HEK293_Human1.11950387
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11691571
63RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11038099
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.10424258
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08725340
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08390964
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07643558
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07286067
69* SPI1_26923725_Chip-Seq_HPCs_Mouse1.07052793
70P53_22387025_ChIP-Seq_ESCs_Mouse1.05920649
71ERG_20517297_ChIP-Seq_VCAP_Human1.05272763
72ESET_19884257_ChIP-Seq_ESCs_Mouse1.03777350
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02988535
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.02548160
75SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01411435
76EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00048733
77P300_18555785_Chip-Seq_ESCs_Mouse0.99887835
78RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99526107
79KLF4_18555785_Chip-Seq_ESCs_Mouse0.99402634
80RARA_24833708_ChIP-Seq_LIVER_Mouse0.99241134
81MYC_27129775_Chip-Seq_CORNEA_Mouse0.99216279
82OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98932834
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.98407376
84GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97806643
85ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97779708
86PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97361424
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97137380
88LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94730259
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94654471
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93458107
91SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93311202
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92225130
93NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91247981
94SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91186160
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.91085694
96SOX9_26525672_Chip-Seq_HEART_Mouse0.89258740
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89018207
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87921585
99STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87238048
100FLI1_21867929_ChIP-Seq_CD8_Mouse0.87114904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.11191571
2MP0001929_abnormal_gametogenesis5.55700694
3MP0008877_abnormal_DNA_methylation4.20838296
4MP0002210_abnormal_sex_determination3.39740826
5MP0002161_abnormal_fertility/fecundity3.32215344
6MP0001145_abnormal_male_reproductive2.89604054
7MP0005670_abnormal_white_adipose2.64364365
8MP0002653_abnormal_ependyma_morphology2.60918843
9MP0000653_abnormal_sex_gland2.51516730
10MP0005410_abnormal_fertilization16.5268193
11MP0005623_abnormal_meninges_morphology1.78612137
12MP0003646_muscle_fatigue1.48820797
13MP0002160_abnormal_reproductive_system1.41309476
14MP0002282_abnormal_trachea_morphology1.35079852
15MP0004233_abnormal_muscle_weight1.27186095
16MP0009046_muscle_twitch1.18233563
17MP0001765_abnormal_ion_homeostasis1.16350766
18MP0008058_abnormal_DNA_repair1.07600807
19MP0001984_abnormal_olfaction1.05203654
20MP0005647_abnormal_sex_gland0.99938044
21MP0008995_early_reproductive_senescence0.77374759
22MP0005389_reproductive_system_phenotype0.72318301
23MP0002234_abnormal_pharynx_morphology0.69324620
24MP0003011_delayed_dark_adaptation0.67772488
25MP0003115_abnormal_respiratory_system0.62411978
26MP0005636_abnormal_mineral_homeostasis0.62350436
27MP0004036_abnormal_muscle_relaxation0.58812827
28MP0005377_hearing/vestibular/ear_phenot0.56057937
29MP0003878_abnormal_ear_physiology0.56057937
30MP0010094_abnormal_chromosome_stability0.54510539
31MP0003699_abnormal_female_reproductive0.51942572
32MP0008057_abnormal_DNA_replication0.51208591
33MP0001324_abnormal_eye_pigmentation0.51099931
34MP0000569_abnormal_digit_pigmentation0.50912737
35MP0005666_abnormal_adipose_tissue0.47314459
36MP0001293_anophthalmia0.46298762
37MP0003329_amyloid_beta_deposits0.45866647
38MP0002928_abnormal_bile_duct0.45744994
39MP0001764_abnormal_homeostasis0.44795487
40MP0001545_abnormal_hematopoietic_system0.44174183
41MP0005397_hematopoietic_system_phenotyp0.44174183
42MP0005253_abnormal_eye_physiology0.42229635
43MP0003950_abnormal_plasma_membrane0.42041302
44MP0000358_abnormal_cell_content/0.41030453
45MP0002736_abnormal_nociception_after0.39861030
46MP0005551_abnormal_eye_electrophysiolog0.38108549
47MP0004133_heterotaxia0.37780126
48MP0002269_muscular_atrophy0.37379847
49MP0009278_abnormal_bone_marrow0.35523241
50MP0003633_abnormal_nervous_system0.34383583
51MP0000534_abnormal_ureter_morphology0.33662940
52MP0006036_abnormal_mitochondrial_physio0.33331819
53MP0003786_premature_aging0.32915453
54MP0001119_abnormal_female_reproductive0.31630667
55MP0009115_abnormal_fat_cell0.31423707
56MP0005391_vision/eye_phenotype0.30491619
57MP0008007_abnormal_cellular_replicative0.30091780
58MP0001730_embryonic_growth_arrest0.27161768
59MP0004019_abnormal_vitamin_homeostasis0.26962787
60MP0004811_abnormal_neuron_physiology0.26565742
61MP0003631_nervous_system_phenotype0.25033597
62MP0003861_abnormal_nervous_system0.24501686
63MP0002971_abnormal_brown_adipose0.24487189
64MP0002139_abnormal_hepatobiliary_system0.24139631
65MP0010307_abnormal_tumor_latency0.24105455
66MP0003111_abnormal_nucleus_morphology0.23886575
67MP0003942_abnormal_urinary_system0.22341084
68MP0002152_abnormal_brain_morphology0.21877619
69MP0004084_abnormal_cardiac_muscle0.21724804
70MP0000604_amyloidosis0.21513220
71MP0001968_abnormal_touch/_nociception0.20799886
72MP0002295_abnormal_pulmonary_circulatio0.19809086
73MP0003948_abnormal_gas_homeostasis0.19669906
74MP0008875_abnormal_xenobiotic_pharmacok0.19661690
75MP0003879_abnormal_hair_cell0.19562631
76MP0003787_abnormal_imprinting0.19312405
77MP0004145_abnormal_muscle_electrophysio0.18362504
78* MP0002169_no_abnormal_phenotype0.17341201
79* MP0002873_normal_phenotype0.17146558
80MP0005423_abnormal_somatic_nervous0.16834099
81MP0000313_abnormal_cell_death0.16558833
82MP0002102_abnormal_ear_morphology0.16216904
83MP0004742_abnormal_vestibular_system0.16182875
84MP0004808_abnormal_hematopoietic_stem0.15599410
85MP0001727_abnormal_embryo_implantation0.15193924
86MP0004043_abnormal_pH_regulation0.14810842
87MP0004270_analgesia0.14476882
88MP0008961_abnormal_basal_metabolism0.13886190
89MP0002229_neurodegeneration0.13754903
90MP0002092_abnormal_eye_morphology0.13619030
91MP0002405_respiratory_system_inflammati0.13545356
92MP0000462_abnormal_digestive_system0.12835213
93MP0002132_abnormal_respiratory_system0.12510183
94MP0002084_abnormal_developmental_patter0.12441925
95MP0005195_abnormal_posterior_eye0.12354315
96MP0001986_abnormal_taste_sensitivity0.11979558
97MP0002572_abnormal_emotion/affect_behav0.11950275
98* MP0000001_mammalian_phenotype0.11929601
99MP0006035_abnormal_mitochondrial_morpho0.11778070
100MP0001849_ear_inflammation0.11235537

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.59535954
2Abnormal respiratory epithelium morphology (HP:0012253)9.04103942
3Abnormal respiratory motile cilium morphology (HP:0005938)9.04103942
4Abnormal ciliary motility (HP:0012262)7.80039280
5Rhinitis (HP:0012384)7.51691220
6Chronic bronchitis (HP:0004469)7.39060087
7Infertility (HP:0000789)6.80927930
8Nasal polyposis (HP:0100582)6.40223326
9Abnormality of the nasal mucosa (HP:0000433)5.26964379
10Male infertility (HP:0003251)5.06029971
11Bronchitis (HP:0012387)4.69992428
12Bronchiectasis (HP:0002110)4.44057607
13Nephronophthisis (HP:0000090)4.14848337
14Abnormal spermatogenesis (HP:0008669)3.88924061
15Recurrent sinusitis (HP:0011108)3.57537010
16Recurrent otitis media (HP:0000403)3.34839376
17Abnormality of the renal medulla (HP:0100957)3.09909617
18Recurrent bronchitis (HP:0002837)2.90613989
19Abnormality of midbrain morphology (HP:0002418)2.78736388
20Molar tooth sign on MRI (HP:0002419)2.78736388
21Tubulointerstitial nephritis (HP:0001970)2.66016416
22Tubular atrophy (HP:0000092)2.62162575
23Medial flaring of the eyebrow (HP:0010747)2.45957293
24Azoospermia (HP:0000027)2.44137888
25Tubulointerstitial abnormality (HP:0001969)2.43804379
26Impulsivity (HP:0100710)2.43190281
27Gonadotropin excess (HP:0000837)2.16648622
28Dyschromatopsia (HP:0007641)2.13626061
29Cholecystitis (HP:0001082)2.10707492
30Abnormal gallbladder physiology (HP:0012438)2.10707492
31Tubulointerstitial fibrosis (HP:0005576)2.09384571
32Decreased central vision (HP:0007663)2.04963746
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5594503
34Absent/shortened dynein arms (HP:0200106)13.3097164
35Dynein arm defect of respiratory motile cilia (HP:0012255)13.3097164
36Postaxial foot polydactyly (HP:0001830)1.89920566
37Abnormal drinking behavior (HP:0030082)1.88786642
38Polydipsia (HP:0001959)1.88786642
39Congenital hepatic fibrosis (HP:0002612)1.83059158
40Choroideremia (HP:0001139)1.79317152
41Spastic tetraparesis (HP:0001285)1.75860960
42Stage 5 chronic kidney disease (HP:0003774)1.72670792
43Abnormal biliary tract physiology (HP:0012439)1.70960325
44Bile duct proliferation (HP:0001408)1.70960325
45Abnormality of renal excretion (HP:0011036)1.67804331
46Abnormality of the renal cortex (HP:0011035)1.66731668
47Fibular hypoplasia (HP:0003038)1.64689072
48Short ribs (HP:0000773)1.63277973
49Pancreatic fibrosis (HP:0100732)1.62500246
50Microglossia (HP:0000171)1.56087429
51Hemorrhage of the eye (HP:0011885)1.56006286
52Oculomotor apraxia (HP:0000657)1.55699054
53Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55018851
54Heterotopia (HP:0002282)1.54566216
55Facial cleft (HP:0002006)1.54451861
56Absent frontal sinuses (HP:0002688)1.50687645
57Renal dysplasia (HP:0000110)1.49720803
58Abnormality of the lower motor neuron (HP:0002366)1.49513871
59Postaxial hand polydactyly (HP:0001162)1.47159497
60Taurodontia (HP:0000679)1.46158582
61Abnormality of permanent molar morphology (HP:0011071)1.46158582
62Abnormality of the dental root (HP:0006486)1.46158582
63Cystic liver disease (HP:0006706)1.45647924
64Deformed sella turcica (HP:0002681)1.44836754
65Bell-shaped thorax (HP:0001591)1.42854717
66J-shaped sella turcica (HP:0002680)1.42488935
67Abnormal urine output (HP:0012590)1.41290411
68Double outlet right ventricle (HP:0001719)1.41179209
69Congenital malformation of the right heart (HP:0011723)1.41179209
70Asymmetric septal hypertrophy (HP:0001670)1.41178290
71Aplasia/Hypoplasia of the lens (HP:0008063)1.40347899
72Decreased electroretinogram (ERG) amplitude (HP:0000654)1.40079302
73Abnormality of dentin (HP:0010299)1.38239829
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.37625246
75Chronic sinusitis (HP:0011109)1.36932635
76Abnormality of molar (HP:0011077)1.36015775
77Abnormality of molar morphology (HP:0011070)1.36015775
78Abnormality of the dental pulp (HP:0006479)1.35526136
79Abnormality of saccadic eye movements (HP:0000570)1.35285086
80Neurofibrillary tangles (HP:0002185)1.34874531
81Median cleft lip (HP:0000161)1.33961222
82Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.32977568
83Amyotrophic lateral sclerosis (HP:0007354)1.30142831
84Bundle branch block (HP:0011710)1.26474784
85Exercise-induced myalgia (HP:0003738)1.25373668
86Congenital primary aphakia (HP:0007707)1.23735189
87Gait imbalance (HP:0002141)1.23454661
88Constricted visual fields (HP:0001133)1.22621713
89Nephropathy (HP:0000112)1.22459524
90Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.21769611
91Absent epiphyses (HP:0010577)1.21769611
92True hermaphroditism (HP:0010459)1.20942224
93Polyuria (HP:0000103)1.20029785
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.19866822
95Short thorax (HP:0010306)1.18481568
96Abnormality of ocular smooth pursuit (HP:0000617)1.17875732
97Myoglobinuria (HP:0002913)1.13812540
98Easy fatigability (HP:0003388)1.12990695
99Chronic hepatic failure (HP:0100626)1.12548223
100Pachygyria (HP:0001302)1.10389182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.25033125
2PDK48.25033125
3TESK15.96830916
4PDK25.34171673
5PRKD35.15603650
6ICK4.25585134
7PTK2B2.51873942
8WNK42.36417850
9STK392.29824834
10STK381.82848123
11PNCK1.79783616
12NEK21.51273624
13DYRK1B1.48509541
14PDK11.24840855
15DYRK30.97205843
16TYRO30.96967781
17WNK10.85110149
18MAPK150.81361220
19PDPK10.77946221
20PASK0.72088123
21CCNB10.69434438
22RIPK40.68206710
23STK38L0.67779545
24TTK0.66752622
25STK30.63188674
26IRAK10.61377428
27CHEK20.60588120
28MAP2K60.59253972
29LMTK20.56788975
30TESK20.56174049
31EEF2K0.54408833
32PINK10.51869507
33BRSK20.45117162
34WEE10.44022226
35CAMK1G0.42933151
36PAK10.41622187
37CHEK10.41544709
38MUSK0.39582203
39NTRK20.37195650
40PRKCG0.36571310
41IRAK20.32452968
42MAPKAPK50.28849932
43ATM0.28648631
44ATR0.28224092
45MAP3K100.28056968
46NEK60.25358452
47PAK20.24818824
48MARK20.22496070
49MAP2K70.21997946
50BRSK10.21404592
51CAMKK10.21082493
52MTOR0.19899619
53CDC70.17886617
54PRKAA10.17515693
55PRKCZ0.17243233
56RPS6KB10.16971365
57PRKCQ0.16021687
58ZAP700.15531943
59PAK40.15136939
60CDK150.15047116
61PLK10.14933092
62PRKG20.13995373
63MAP3K40.12634056
64PLK40.12517145
65CDK180.12345737
66STK100.12169478
67CDK11A0.11220765
68MARK30.09814781
69CSNK2A10.08289778
70BRAF0.08216695
71CDK140.07228311
72GSK3B0.06932658
73RPS6KA10.06852988
74STK110.05739318
75PDGFRB0.05613965
76PRKG10.05126802
77CSF1R0.04673417
78PRKCD0.04527572
79CDK10.04524330
80CSNK2A20.04318132
81CAMK2A0.04042315
82PRKACG0.03707989
83MAPK80.03544787
84CDK20.03484886
85AURKA0.01871563
86CSNK1D0.01803670
87PKN10.01799676
88PRKCB0.01074572
89PRKCA0.00821353
90CDK60.00747257
91PIM10.00141144
92CDK3-0.0361287
93CDK4-0.0353728
94MAP3K1-0.0330313
95MAP3K5-0.0275470
96PAK6-0.0263224
97PRKACA-0.0239537
98EGFR-0.0209705
99PRKDC-0.0096734
100WNK3-0.0064238

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.52988419
2Fatty acid biosynthesis_Homo sapiens_hsa000614.47771311
3Vitamin B6 metabolism_Homo sapiens_hsa007504.05832150
4Pyruvate metabolism_Homo sapiens_hsa006203.59692617
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98613993
6Linoleic acid metabolism_Homo sapiens_hsa005912.92133473
7Propanoate metabolism_Homo sapiens_hsa006402.87015245
8Glucagon signaling pathway_Homo sapiens_hsa049222.63948657
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.55531603
10Basal transcription factors_Homo sapiens_hsa030222.44572481
11Pentose phosphate pathway_Homo sapiens_hsa000302.30065360
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.16870089
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06047811
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.01198224
15Glycerolipid metabolism_Homo sapiens_hsa005611.91979044
16PPAR signaling pathway_Homo sapiens_hsa033201.82503479
17Selenocompound metabolism_Homo sapiens_hsa004501.73912841
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73164143
19Oocyte meiosis_Homo sapiens_hsa041141.66389820
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.66280594
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.65980959
22Amphetamine addiction_Homo sapiens_hsa050311.52599592
23Fructose and mannose metabolism_Homo sapiens_hsa000511.52233361
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51491918
25Mineral absorption_Homo sapiens_hsa049781.50287673
26Carbon metabolism_Homo sapiens_hsa012001.47747953
27Fat digestion and absorption_Homo sapiens_hsa049751.44092612
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40414947
29Fanconi anemia pathway_Homo sapiens_hsa034601.38748813
30Ether lipid metabolism_Homo sapiens_hsa005651.37251984
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36544860
32Fatty acid degradation_Homo sapiens_hsa000711.34029549
33Dorso-ventral axis formation_Homo sapiens_hsa043201.33309859
34Fatty acid metabolism_Homo sapiens_hsa012121.32426191
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.26991238
36Cardiac muscle contraction_Homo sapiens_hsa042601.26012708
37Renin secretion_Homo sapiens_hsa049241.13666574
38Biosynthesis of amino acids_Homo sapiens_hsa012301.11828354
39Renin-angiotensin system_Homo sapiens_hsa046141.09128907
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04443441
41Huntingtons disease_Homo sapiens_hsa050161.02760405
42Purine metabolism_Homo sapiens_hsa002301.00305340
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98114426
44Antigen processing and presentation_Homo sapiens_hsa046120.97020123
45mRNA surveillance pathway_Homo sapiens_hsa030150.96778721
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91635386
47Glutathione metabolism_Homo sapiens_hsa004800.84917501
48RNA transport_Homo sapiens_hsa030130.83050955
49Insulin secretion_Homo sapiens_hsa049110.81106560
50Collecting duct acid secretion_Homo sapiens_hsa049660.80865973
51Chemical carcinogenesis_Homo sapiens_hsa052040.77160537
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.76072410
53Long-term potentiation_Homo sapiens_hsa047200.75011514
54Arachidonic acid metabolism_Homo sapiens_hsa005900.74367292
55Hedgehog signaling pathway_Homo sapiens_hsa043400.71984273
56Thyroid hormone synthesis_Homo sapiens_hsa049180.70602009
57Bile secretion_Homo sapiens_hsa049760.67659378
58Estrogen signaling pathway_Homo sapiens_hsa049150.66198480
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65914100
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61161810
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59002912
62Pancreatic secretion_Homo sapiens_hsa049720.52874032
63Calcium signaling pathway_Homo sapiens_hsa040200.51317239
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.51144099
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50546745
66Sulfur metabolism_Homo sapiens_hsa009200.48630066
67Legionellosis_Homo sapiens_hsa051340.47569376
68Salivary secretion_Homo sapiens_hsa049700.47031047
69Systemic lupus erythematosus_Homo sapiens_hsa053220.46884940
70Endocytosis_Homo sapiens_hsa041440.45926621
71ABC transporters_Homo sapiens_hsa020100.43565189
72AMPK signaling pathway_Homo sapiens_hsa041520.43549170
73Protein digestion and absorption_Homo sapiens_hsa049740.43491516
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.40527195
75Synaptic vesicle cycle_Homo sapiens_hsa047210.39655043
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37479691
77Metabolic pathways_Homo sapiens_hsa011000.37350400
78Taste transduction_Homo sapiens_hsa047420.36806912
79Inositol phosphate metabolism_Homo sapiens_hsa005620.35657034
80Gastric acid secretion_Homo sapiens_hsa049710.35495763
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34757699
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33874508
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32533798
84VEGF signaling pathway_Homo sapiens_hsa043700.30213249
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29215700
86cAMP signaling pathway_Homo sapiens_hsa040240.27955129
87Cocaine addiction_Homo sapiens_hsa050300.24219253
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23064946
89Circadian entrainment_Homo sapiens_hsa047130.20950719
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18664855
91Alcoholism_Homo sapiens_hsa050340.18608493
92Pyrimidine metabolism_Homo sapiens_hsa002400.18480337
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15007688
94Salmonella infection_Homo sapiens_hsa051320.12452426
95B cell receptor signaling pathway_Homo sapiens_hsa046620.08639352
96Wnt signaling pathway_Homo sapiens_hsa043100.08120568
97Lysine degradation_Homo sapiens_hsa003100.07799450
98Viral carcinogenesis_Homo sapiens_hsa052030.07579575
99Glutamatergic synapse_Homo sapiens_hsa047240.07220319
100RNA degradation_Homo sapiens_hsa030180.06507900

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