MBD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.53484037
2vocalization behavior (GO:0071625)4.61281963
3locomotory exploration behavior (GO:0035641)4.59840722
4presynaptic membrane assembly (GO:0097105)4.59318657
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.47771096
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.35316394
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.30592733
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.20391390
9establishment of protein localization to Golgi (GO:0072600)4.17475477
10fucose catabolic process (GO:0019317)4.13661619
11L-fucose metabolic process (GO:0042354)4.13661619
12L-fucose catabolic process (GO:0042355)4.13661619
13glutamate receptor signaling pathway (GO:0007215)4.04816596
14behavioral response to nicotine (GO:0035095)3.96717505
15postsynaptic membrane organization (GO:0001941)3.95113136
16presynaptic membrane organization (GO:0097090)3.94893937
17L-amino acid import (GO:0043092)3.94455672
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93308666
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87051440
20dendritic spine morphogenesis (GO:0060997)3.85069181
21regulation of glutamate receptor signaling pathway (GO:1900449)3.82942207
22protein localization to synapse (GO:0035418)3.77512683
23interkinetic nuclear migration (GO:0022027)3.76532635
24neural tube formation (GO:0001841)3.73935389
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.73338484
26G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.70437603
27synaptic vesicle exocytosis (GO:0016079)3.68026305
28regulation of synaptic vesicle exocytosis (GO:2000300)3.66598246
29synaptic transmission, glutamatergic (GO:0035249)3.63817340
30synaptic vesicle endocytosis (GO:0048488)3.62350705
31transmission of nerve impulse (GO:0019226)3.58181535
32neurotransmitter-gated ion channel clustering (GO:0072578)3.47329018
33exploration behavior (GO:0035640)3.46854463
34neuron-neuron synaptic transmission (GO:0007270)3.46432459
35neuron recognition (GO:0008038)3.45825574
36regulation of translation, ncRNA-mediated (GO:0045974)3.44481854
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.44481854
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.44481854
39protein targeting to Golgi (GO:0000042)3.43073542
40neuronal ion channel clustering (GO:0045161)3.36958893
41protein K11-linked deubiquitination (GO:0035871)3.36836660
42central nervous system projection neuron axonogenesis (GO:0021952)3.35934333
43retrograde transport, vesicle recycling within Golgi (GO:0000301)3.30782899
44regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30494968
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29355309
46tryptophan catabolic process (GO:0006569)3.29308446
47indole-containing compound catabolic process (GO:0042436)3.29308446
48indolalkylamine catabolic process (GO:0046218)3.29308446
49synaptic vesicle maturation (GO:0016188)3.29152663
50startle response (GO:0001964)3.28841143
51neuronal action potential propagation (GO:0019227)3.27622808
52negative regulation of cytosolic calcium ion concentration (GO:0051481)3.25562541
53detection of light stimulus involved in visual perception (GO:0050908)3.25341616
54detection of light stimulus involved in sensory perception (GO:0050962)3.25341616
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.24467905
56dendrite morphogenesis (GO:0048813)3.24310760
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23077643
58axonal fasciculation (GO:0007413)3.22899916
59positive regulation of developmental pigmentation (GO:0048087)3.21236050
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.20505237
61glutamate secretion (GO:0014047)3.19444432
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.18269018
63long-term memory (GO:0007616)3.15377126
64regulation of synaptic vesicle transport (GO:1902803)3.13934279
65regulation of pigment cell differentiation (GO:0050932)3.13403905
66amino acid import (GO:0043090)3.12287987
67indolalkylamine metabolic process (GO:0006586)3.10322487
68long-term synaptic potentiation (GO:0060291)3.10083019
69regulation of hippo signaling (GO:0035330)3.07151304
70regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06616339
71synapse assembly (GO:0007416)3.04124199
72cerebellar Purkinje cell differentiation (GO:0021702)3.03665819
73positive regulation of synapse assembly (GO:0051965)3.03578197
74regulation of neuronal synaptic plasticity (GO:0048168)3.02168809
75positive regulation of membrane potential (GO:0045838)3.01242185
76regulation of long-term neuronal synaptic plasticity (GO:0048169)3.01025544
77cellular potassium ion homeostasis (GO:0030007)2.99405444
78regulation of postsynaptic membrane potential (GO:0060078)2.98530900
79regulation of respiratory system process (GO:0044065)2.98156488
80membrane hyperpolarization (GO:0060081)2.97300735
81positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.95443094
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94416696
83cAMP catabolic process (GO:0006198)2.91472533
84long-chain fatty acid biosynthetic process (GO:0042759)2.91244896
85regulation of dendritic spine morphogenesis (GO:0061001)2.91087712
86innervation (GO:0060384)2.89036632
87adult walking behavior (GO:0007628)2.88778492
88response to histamine (GO:0034776)2.86816942
89protein localization to Golgi apparatus (GO:0034067)2.86327521
90photoreceptor cell maintenance (GO:0045494)2.85554565
91negative regulation of neurotransmitter secretion (GO:0046929)2.85209733
92snRNA transcription (GO:0009301)2.84049657
93cerebellar granule cell differentiation (GO:0021707)2.83729703
94synaptic vesicle docking involved in exocytosis (GO:0016081)2.83541595
95membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82519615
96negative regulation of neurotransmitter transport (GO:0051589)2.82351547
97reflex (GO:0060004)2.82196647
98neuronal action potential (GO:0019228)2.82124683
99pyrimidine nucleobase catabolic process (GO:0006208)2.81933782
100monoubiquitinated protein deubiquitination (GO:0035520)2.81908784
101regulation of vesicle fusion (GO:0031338)2.81862964
102cyclic nucleotide catabolic process (GO:0009214)2.81789752
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80100849
104cilium or flagellum-dependent cell motility (GO:0001539)2.79647878
105regulation of respiratory gaseous exchange (GO:0043576)2.79191360
106kynurenine metabolic process (GO:0070189)2.78663549
107response to pheromone (GO:0019236)2.77940907
108nonmotile primary cilium assembly (GO:0035058)2.77108808
109neurotransmitter secretion (GO:0007269)2.76899913
110regulation of synapse structural plasticity (GO:0051823)2.76492648
111protein K48-linked deubiquitination (GO:0071108)2.75172235
112learning (GO:0007612)2.74619532
113central nervous system neuron axonogenesis (GO:0021955)2.74239389
114protein polyglutamylation (GO:0018095)2.73834232
115negative regulation of mast cell activation (GO:0033004)2.73816844
116tryptophan metabolic process (GO:0006568)2.72626578
117gamma-aminobutyric acid transport (GO:0015812)2.72420557
118microtubule anchoring (GO:0034453)2.69217632
119synapse organization (GO:0050808)2.68901272
120righting reflex (GO:0060013)2.68445629
121cerebral cortex radially oriented cell migration (GO:0021799)2.68417740
122cilium morphogenesis (GO:0060271)2.68152157
123regulation of neurotransmitter secretion (GO:0046928)2.67828846
124regulation of sarcomere organization (GO:0060297)2.67438166
125protein prenylation (GO:0018342)2.66596477
126prenylation (GO:0097354)2.66596477
127positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.65721484
128neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.65620578
129calcium ion import (GO:0070509)2.64842498
130axon ensheathment in central nervous system (GO:0032291)2.64274542
131central nervous system myelination (GO:0022010)2.64274542
132nucleus localization (GO:0051647)2.64191839
133dendritic spine organization (GO:0097061)2.63295400
134auditory behavior (GO:0031223)2.62721986
135limb development (GO:0060173)2.62143317
136appendage development (GO:0048736)2.62143317
137regulation of dendritic spine development (GO:0060998)2.61569318
138membrane depolarization (GO:0051899)2.60830342
139negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58810867
140retinal cone cell development (GO:0046549)2.58715497
141regulation of synaptic plasticity (GO:0048167)2.58517306
142axoneme assembly (GO:0035082)2.58414902
143regulation of synapse assembly (GO:0051963)2.58044388
144cilium organization (GO:0044782)2.57873154
145regulation of establishment of cell polarity (GO:2000114)2.56922381
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.56759558
147histone H3-K9 methylation (GO:0051567)2.55500861
148positive regulation of dendritic spine development (GO:0060999)2.54932692
149cilium assembly (GO:0042384)2.54162048
150protein K63-linked deubiquitination (GO:0070536)2.53391697
151behavioral response to ethanol (GO:0048149)2.53340556
152regulation of cilium movement (GO:0003352)2.53317999
153membrane depolarization during action potential (GO:0086010)2.52942320
154histone H3-K4 trimethylation (GO:0080182)2.52917110
155response to auditory stimulus (GO:0010996)2.52671465
156behavioral fear response (GO:0001662)2.51708741
157behavioral defense response (GO:0002209)2.51708741
158striatum development (GO:0021756)2.51589319
159neurotransmitter transport (GO:0006836)2.50056606
160proline transport (GO:0015824)2.48533729
161cellular ketone body metabolic process (GO:0046950)2.46318952
162phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.46124232
163detection of mechanical stimulus involved in sensory perception (GO:0050974)2.45394073
164protein localization to cilium (GO:0061512)2.43081874
165sulfation (GO:0051923)2.43079389
166epithelial cilium movement (GO:0003351)2.40171706
167kidney morphogenesis (GO:0060993)2.39733924
168regulation of posttranscriptional gene silencing (GO:0060147)2.39135814
169regulation of gene silencing by miRNA (GO:0060964)2.39135814
170regulation of gene silencing by RNA (GO:0060966)2.39135814
171phospholipid translocation (GO:0045332)2.37642782
172lipid translocation (GO:0034204)2.37642782
173regulation of action potential (GO:0098900)2.36758157
174protein targeting to vacuole (GO:0006623)2.35296405
175protein targeting to lysosome (GO:0006622)2.35296405
176establishment of protein localization to vacuole (GO:0072666)2.35296405
177inner ear receptor stereocilium organization (GO:0060122)2.33232619
178nucleobase catabolic process (GO:0046113)2.31725500
179pericardium development (GO:0060039)2.30879007
180indole-containing compound metabolic process (GO:0042430)2.28857199
181tachykinin receptor signaling pathway (GO:0007217)2.28855802
182cellular response to ethanol (GO:0071361)2.28052468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59526773
2GBX2_23144817_ChIP-Seq_PC3_Human3.95146343
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59670682
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59072904
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44287069
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38740292
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.22628043
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20383050
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18026884
10TAF15_26573619_Chip-Seq_HEK293_Human2.16065567
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15075428
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15075428
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12129698
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10240289
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.05939042
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04553329
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.02962793
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01985532
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01422370
20* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01250445
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00542865
22DROSHA_22980978_ChIP-Seq_HELA_Human2.00271868
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94773900
24AR_21572438_ChIP-Seq_LNCaP_Human1.94562532
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.93458997
26REST_21632747_ChIP-Seq_MESCs_Mouse1.91705825
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88861022
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88494857
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.87698658
30* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81481262
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.80823182
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80379215
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.77843865
34P300_19829295_ChIP-Seq_ESCs_Human1.76682915
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74474627
36IGF1R_20145208_ChIP-Seq_DFB_Human1.70494279
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.66493045
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65944678
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.65097666
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.61641705
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60825744
42FUS_26573619_Chip-Seq_HEK293_Human1.59409360
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57164717
44BCAT_22108803_ChIP-Seq_LS180_Human1.57160686
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51411602
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50699190
47CBP_20019798_ChIP-Seq_JUKART_Human1.50670589
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50670589
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49346923
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47930201
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47909263
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47821153
53STAT3_23295773_ChIP-Seq_U87_Human1.46028722
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45774461
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.44742865
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42508524
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42276684
58ER_23166858_ChIP-Seq_MCF-7_Human1.42169097
59* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40569820
60* NANOG_18555785_Chip-Seq_ESCs_Mouse1.40131696
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40126090
62AR_25329375_ChIP-Seq_VCAP_Human1.38625739
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38537564
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.37665116
65RNF2_27304074_Chip-Seq_NSC_Mouse1.35149256
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34908272
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34908272
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.34887990
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33582621
70TCF4_23295773_ChIP-Seq_U87_Human1.32755007
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30995721
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30678582
73TP53_16413492_ChIP-PET_HCT116_Human1.30201759
74* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28218012
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28009865
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.27734361
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27480655
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27321841
79TCF4_22108803_ChIP-Seq_LS180_Human1.24721999
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23702648
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23436014
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22652859
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.22214317
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21594387
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21230714
86* E2F1_18555785_Chip-Seq_ESCs_Mouse1.20417902
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.20364528
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20343475
89* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20041945
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19789088
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19511314
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19005788
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18483817
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.15866917
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15781500
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15118172
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.14945535
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13806332
99KDM2B_26808549_Chip-Seq_REH_Human1.13150711
100* AR_19668381_ChIP-Seq_PC3_Human1.12998439
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.12784153
102AHR_22903824_ChIP-Seq_MCF-7_Human1.10668995
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.09922770
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09806151
105* P53_22387025_ChIP-Seq_ESCs_Mouse1.09501787
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09432398
107IRF1_19129219_ChIP-ChIP_H3396_Human1.06858930
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06470728
109TP53_18474530_ChIP-ChIP_U2OS_Human1.06448223
110* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06331695
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.05919727
112VDR_22108803_ChIP-Seq_LS180_Human1.05787796
113CDX2_22108803_ChIP-Seq_LS180_Human1.05777779
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05717222
115EWS_26573619_Chip-Seq_HEK293_Human1.05715088
116* NANOG_19829295_ChIP-Seq_ESCs_Human1.05123449
117* SOX2_19829295_ChIP-Seq_ESCs_Human1.05123449
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04548355
119NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04448142
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04448142
121PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04151563
122ZNF274_21170338_ChIP-Seq_K562_Hela1.03263352
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03175819
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02787894
125SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02516031
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02150311
127OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01701895
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01607524
129* TP53_22573176_ChIP-Seq_HFKS_Human1.00915728
130* P300_18555785_Chip-Seq_ESCs_Mouse0.99980289
131RING1B_27294783_Chip-Seq_ESCs_Mouse0.99871818
132FLI1_27457419_Chip-Seq_LIVER_Mouse0.99866746
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.98802129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.10735093
2MP0004859_abnormal_synaptic_plasticity4.45551358
3MP0003635_abnormal_synaptic_transmissio3.31699802
4MP0001486_abnormal_startle_reflex2.87329192
5MP0004270_analgesia2.86920993
6MP0009745_abnormal_behavioral_response2.82677364
7MP0008877_abnormal_DNA_methylation2.73900218
8MP0002064_seizures2.68700449
9MP0002063_abnormal_learning/memory/cond2.68113036
10MP0009046_muscle_twitch2.63246305
11MP0002572_abnormal_emotion/affect_behav2.59691941
12MP0005423_abnormal_somatic_nervous2.50951283
13MP0000569_abnormal_digit_pigmentation2.37545349
14MP0001968_abnormal_touch/_nociception2.36789042
15MP0001188_hyperpigmentation2.36661944
16MP0002272_abnormal_nervous_system2.33071541
17MP0003195_calcinosis2.27974999
18MP0005409_darkened_coat_color2.25809065
19MP0000778_abnormal_nervous_system2.20045422
20MP0001529_abnormal_vocalization2.11181403
21MP0000427_abnormal_hair_cycle2.05260283
22MP0002734_abnormal_mechanical_nocicepti2.04703518
23MP0008057_abnormal_DNA_replication2.03784485
24MP0003787_abnormal_imprinting1.98840973
25MP0003646_muscle_fatigue1.97538141
26MP0004043_abnormal_pH_regulation1.96646634
27MP0005551_abnormal_eye_electrophysiolog1.96605767
28MP0001984_abnormal_olfaction1.95552132
29MP0002067_abnormal_sensory_capabilities1.91871921
30MP0001501_abnormal_sleep_pattern1.90898542
31MP0006276_abnormal_autonomic_nervous1.89811016
32MP0002735_abnormal_chemical_nociception1.81843399
33MP0005646_abnormal_pituitary_gland1.81093262
34MP0002184_abnormal_innervation1.80984115
35MP0002822_catalepsy1.76098589
36MP0001440_abnormal_grooming_behavior1.75121738
37MP0001502_abnormal_circadian_rhythm1.69058123
38MP0002736_abnormal_nociception_after1.68034835
39MP0006292_abnormal_olfactory_placode1.67700272
40MP0002557_abnormal_social/conspecific_i1.65348263
41MP0009780_abnormal_chondrocyte_physiolo1.61008802
42MP0005386_behavior/neurological_phenoty1.59558707
43MP0004924_abnormal_behavior1.59558707
44MP0000383_abnormal_hair_follicle1.59110215
45MP0002163_abnormal_gland_morphology1.55862337
46MP0004742_abnormal_vestibular_system1.53278201
47MP0008569_lethality_at_weaning1.53039742
48MP0005645_abnormal_hypothalamus_physiol1.52610260
49MP0005174_abnormal_tail_pigmentation1.52112910
50MP0002876_abnormal_thyroid_physiology1.48548557
51MP0002733_abnormal_thermal_nociception1.48501759
52MP0008872_abnormal_physiological_respon1.48119403
53MP0001970_abnormal_pain_threshold1.46707748
54MP0003122_maternal_imprinting1.45102068
55MP0002882_abnormal_neuron_morphology1.42670689
56MP0005171_absent_coat_pigmentation1.37891569
57MP0005379_endocrine/exocrine_gland_phen1.37351500
58MP0002102_abnormal_ear_morphology1.34382226
59MP0004885_abnormal_endolymph1.33784902
60MP0000920_abnormal_myelination1.32970085
61MP0000955_abnormal_spinal_cord1.31733704
62MP0001905_abnormal_dopamine_level1.30008287
63MP0003890_abnormal_embryonic-extraembry1.29633483
64MP0004142_abnormal_muscle_tone1.29072727
65MP0002638_abnormal_pupillary_reflex1.27140252
66MP0002928_abnormal_bile_duct1.23315884
67MP0001986_abnormal_taste_sensitivity1.21883115
68MP0002066_abnormal_motor_capabilities/c1.18674779
69MP0000631_abnormal_neuroendocrine_gland1.16738609
70MP0006072_abnormal_retinal_apoptosis1.16195859
71MP0003690_abnormal_glial_cell1.15327785
72MP0000372_irregular_coat_pigmentation1.14860177
73MP0004811_abnormal_neuron_physiology1.10325971
74MP0005187_abnormal_penis_morphology1.09602289
75MP0001177_atelectasis1.09586330
76MP0002938_white_spotting1.08466761
77MP0003879_abnormal_hair_cell1.07086859
78MP0005253_abnormal_eye_physiology1.05542833
79MP0002152_abnormal_brain_morphology1.05194331
80MP0002752_abnormal_somatic_nervous1.04504243
81MP0010386_abnormal_urinary_bladder1.03526827
82MP0000566_synostosis1.01786912
83MP0002229_neurodegeneration1.00647396
84MP0004130_abnormal_muscle_cell0.99763734
85MP0003632_abnormal_nervous_system0.97117378
86MP0003121_genomic_imprinting0.96876620
87MP0002090_abnormal_vision0.96647251
88MP0004147_increased_porphyrin_level0.96416616
89MP0000015_abnormal_ear_pigmentation0.94668519
90MP0000230_abnormal_systemic_arterial0.93327511
91MP0002160_abnormal_reproductive_system0.92607416
92MP0003634_abnormal_glial_cell0.92108185
93MP0003631_nervous_system_phenotype0.91113676
94MP0001299_abnormal_eye_distance/0.90728480
95MP0002095_abnormal_skin_pigmentation0.90053467
96MP0002751_abnormal_autonomic_nervous0.90046833
97MP0001963_abnormal_hearing_physiology0.89753267
98MP0002909_abnormal_adrenal_gland0.88941569
99MP0003045_fibrosis0.88901828
100MP0005167_abnormal_blood-brain_barrier0.88271570
101MP0003633_abnormal_nervous_system0.87375919
102MP0003329_amyloid_beta_deposits0.86469249
103MP0004134_abnormal_chest_morphology0.86397020
104MP0004133_heterotaxia0.85808434
105MP0003136_yellow_coat_color0.85783654
106MP0005195_abnormal_posterior_eye0.84115123
107MP0004858_abnormal_nervous_system0.84102512
108MP0002837_dystrophic_cardiac_calcinosis0.83965671
109MP0005389_reproductive_system_phenotype0.83158061
110MP0001485_abnormal_pinna_reflex0.81835778
111MP0003698_abnormal_male_reproductive0.80703415
112MP0003183_abnormal_peptide_metabolism0.78963044
113MP0008961_abnormal_basal_metabolism0.78662775
114MP0008775_abnormal_heart_ventricle0.78405078
115MP0002234_abnormal_pharynx_morphology0.77510408
116MP0003252_abnormal_bile_duct0.76651624
117MP0003937_abnormal_limbs/digits/tail_de0.76456601
118MP0004145_abnormal_muscle_electrophysio0.76437469
119MP0005220_abnormal_exocrine_pancreas0.76253083
120MP0004084_abnormal_cardiac_muscle0.74794953
121MP0010678_abnormal_skin_adnexa0.72894864
122MP0002653_abnormal_ependyma_morphology0.72402859
123MP0003137_abnormal_impulse_conducting0.72266755
124MP0000516_abnormal_urinary_system0.72266101
125MP0000013_abnormal_adipose_tissue0.71290863
126MP0000026_abnormal_inner_ear0.69521705
127MP0002069_abnormal_eating/drinking_beha0.69388342
128MP0004085_abnormal_heartbeat0.68649015
129MP0003938_abnormal_ear_development0.68016085
130MP0000462_abnormal_digestive_system0.67281877
131MP0004215_abnormal_myocardial_fiber0.66546029
132MP0005394_taste/olfaction_phenotype0.64254793
133MP0005499_abnormal_olfactory_system0.64254793
134MP0002177_abnormal_outer_ear0.62788564
135MP0009250_abnormal_appendicular_skeleto0.61700507
136MP0001346_abnormal_lacrimal_gland0.61655671
137MP0003172_abnormal_lysosome_physiology0.61491253
138MP0002089_abnormal_postnatal_growth/wei0.61177774
139MP0003861_abnormal_nervous_system0.60385117

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.51485847
2Progressive cerebellar ataxia (HP:0002073)4.46368406
3Focal seizures (HP:0007359)4.44667402
4Pancreatic cysts (HP:0001737)4.21078204
5Epileptic encephalopathy (HP:0200134)4.06039637
6Atonic seizures (HP:0010819)4.01235989
7* Febrile seizures (HP:0002373)3.89576179
8Abnormality of the renal cortex (HP:0011035)3.78797688
9Broad-based gait (HP:0002136)3.48902144
10True hermaphroditism (HP:0010459)3.44677903
11Abnormality of midbrain morphology (HP:0002418)3.36712999
12Molar tooth sign on MRI (HP:0002419)3.36712999
13Nephronophthisis (HP:0000090)3.35396354
14Absence seizures (HP:0002121)3.32332815
15Abnormality of the renal medulla (HP:0100957)3.27527169
16Myokymia (HP:0002411)3.27411885
17Dialeptic seizures (HP:0011146)3.25076199
18Chronic hepatic failure (HP:0100626)3.18445102
19Renal cortical cysts (HP:0000803)3.06320708
20Gaze-evoked nystagmus (HP:0000640)3.02225856
21Congenital stationary night blindness (HP:0007642)2.89382550
22Action tremor (HP:0002345)2.76913832
23Attenuation of retinal blood vessels (HP:0007843)2.71358696
24Cystic liver disease (HP:0006706)2.69840151
25Inability to walk (HP:0002540)2.66874935
26Dysdiadochokinesis (HP:0002075)2.66621509
27Truncal ataxia (HP:0002078)2.63808100
28Central scotoma (HP:0000603)2.62239349
29Hyperventilation (HP:0002883)2.61106733
30Generalized tonic-clonic seizures (HP:0002069)2.60758337
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.59334239
32Excessive salivation (HP:0003781)2.57953200
33Drooling (HP:0002307)2.57953200
34Oligodactyly (hands) (HP:0001180)2.54741946
35Absent speech (HP:0001344)2.52742897
36Dysmetria (HP:0001310)2.52187339
37Hypoplastic ischia (HP:0003175)2.51824911
38Tubulointerstitial nephritis (HP:0001970)2.49233939
39Fetal akinesia sequence (HP:0001989)2.48660947
40Visual hallucinations (HP:0002367)2.48428855
41Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47587315
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.47587315
43Genetic anticipation (HP:0003743)2.46745890
44Abnormality of the ischium (HP:0003174)2.46611615
45Protruding tongue (HP:0010808)2.43738463
46Blue irides (HP:0000635)2.43626668
47Abnormality of the corticospinal tract (HP:0002492)2.43149748
48Aqueductal stenosis (HP:0002410)2.40793299
49Abnormal hair whorl (HP:0010721)2.40098066
50Tubular atrophy (HP:0000092)2.33514732
51Fair hair (HP:0002286)2.33045848
52Urinary bladder sphincter dysfunction (HP:0002839)2.32150551
53Abolished electroretinogram (ERG) (HP:0000550)2.28234038
54Chorioretinal atrophy (HP:0000533)2.25987945
55Poor coordination (HP:0002370)2.23733030
56Parakeratosis (HP:0001036)2.23640020
57Abnormality of macular pigmentation (HP:0008002)2.23143942
58Increased corneal curvature (HP:0100692)2.22557854
59Keratoconus (HP:0000563)2.22557854
60Scanning speech (HP:0002168)2.21459058
61Decreased circulating renin level (HP:0003351)2.20547406
62Retinal dysplasia (HP:0007973)2.19304200
63Gait imbalance (HP:0002141)2.17981894
64Intestinal atresia (HP:0011100)2.17558929
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.16084095
66Congenital hepatic fibrosis (HP:0002612)2.14169510
67Lissencephaly (HP:0001339)2.12869267
68Epileptiform EEG discharges (HP:0011182)2.12607246
69Supranuclear gaze palsy (HP:0000605)2.10604794
70Absent/shortened dynein arms (HP:0200106)2.10493462
71Dynein arm defect of respiratory motile cilia (HP:0012255)2.10493462
72Hypoplastic nipples (HP:0002557)2.08851434
73Termporal pattern (HP:0011008)2.08660338
74Insidious onset (HP:0003587)2.08660338
75Polydipsia (HP:0001959)2.07765356
76Abnormal drinking behavior (HP:0030082)2.07765356
77Medial flaring of the eyebrow (HP:0010747)2.07050971
78Generalized hypopigmentation of hair (HP:0011358)2.06440077
79Hemiparesis (HP:0001269)2.05924961
80Narrow nasal bridge (HP:0000446)2.05467215
81Mixed hearing impairment (HP:0000410)2.03951543
82Neurofibrillary tangles (HP:0002185)2.02871233
83Postaxial foot polydactyly (HP:0001830)2.02824082
84Anteriorly placed anus (HP:0001545)2.02340280
85Poor eye contact (HP:0000817)2.02247449
86Bony spicule pigmentary retinopathy (HP:0007737)2.01646851
87EEG with generalized epileptiform discharges (HP:0011198)2.00251034
88* Widely spaced teeth (HP:0000687)2.00197146
89Intention tremor (HP:0002080)1.99256369
90Hypoplastic iliac wings (HP:0002866)1.99151036
91Abnormality of salivation (HP:0100755)1.98749879
92Congenital sensorineural hearing impairment (HP:0008527)1.97812011
93Aplasia involving bones of the extremities (HP:0009825)1.96626896
94Aplasia involving bones of the upper limbs (HP:0009823)1.96626896
95Aplasia of the phalanges of the hand (HP:0009802)1.96626896
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95772403
97Decreased central vision (HP:0007663)1.95123406
98Pachygyria (HP:0001302)1.95118217
99Genital tract atresia (HP:0001827)1.95039074
100Stomach cancer (HP:0012126)1.94520169
101Abnormality of the pubic bones (HP:0003172)1.93721128
102Congenital primary aphakia (HP:0007707)1.93558627
103Abnormality of alanine metabolism (HP:0010916)1.93270947
104Hyperalaninemia (HP:0003348)1.93270947
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93270947
106Abnormality of incisor morphology (HP:0011063)1.93158800
107Sensory axonal neuropathy (HP:0003390)1.92985176
108Furrowed tongue (HP:0000221)1.92347237
109Tubulointerstitial abnormality (HP:0001969)1.92064935
110Abnormality of the parathyroid morphology (HP:0011766)1.91523766
111Dyschromatopsia (HP:0007641)1.90567193
112Nephrogenic diabetes insipidus (HP:0009806)1.90370362
113Thyroid-stimulating hormone excess (HP:0002925)1.90154162
114Papillary thyroid carcinoma (HP:0002895)1.87428344
115Impaired vibration sensation in the lower limbs (HP:0002166)1.86933056
116Anencephaly (HP:0002323)1.86834631
117Alacrima (HP:0000522)1.86723705
118Steppage gait (HP:0003376)1.85798495
119Cerebellar dysplasia (HP:0007033)1.85371461
120Postaxial hand polydactyly (HP:0001162)1.84117837
121Thickened helices (HP:0000391)1.83690214
122Vaginal atresia (HP:0000148)1.83010423
123Small epiphyses (HP:0010585)1.82015770
124Lower limb muscle weakness (HP:0007340)1.81858174
125Hip dysplasia (HP:0001385)1.81577029
126Postural instability (HP:0002172)1.80351791
127Midline defect of the nose (HP:0004122)1.80286438
128Abnormality of the nasal septum (HP:0000419)1.79932369
129Progressive inability to walk (HP:0002505)1.79683331
130Spastic gait (HP:0002064)1.79410103
131Septo-optic dysplasia (HP:0100842)1.79255639
132Impaired social interactions (HP:0000735)1.79150332
133Abnormal social behavior (HP:0012433)1.79150332
134* Short foot (HP:0001773)1.78590824
135Exotropia (HP:0000577)1.76954992
136Decreased lacrimation (HP:0000633)1.75588092
137* Stereotypic behavior (HP:0000733)1.75520261
138Narrow forehead (HP:0000341)1.75221595
139Sclerocornea (HP:0000647)1.73305016
140Scotoma (HP:0000575)1.72439843
141Optic nerve hypoplasia (HP:0000609)1.70445216
142Hypsarrhythmia (HP:0002521)1.70152020
143Cutaneous finger syndactyly (HP:0010554)1.68890011
144Peripheral hypomyelination (HP:0007182)1.68241356
145Pancreatic fibrosis (HP:0100732)1.67971284
146Hypothermia (HP:0002045)1.67955172
147Male pseudohermaphroditism (HP:0000037)1.67789464
148* Bulbous nose (HP:0000414)1.67692209
149Anxiety (HP:0000739)1.67507391
150Abnormality of ocular smooth pursuit (HP:0000617)1.67363099
151Large for gestational age (HP:0001520)1.67338464
152Type II lissencephaly (HP:0007260)1.66674684
153Deeply set eye (HP:0000490)1.66335411
154Clumsiness (HP:0002312)1.66184779
155Megalencephaly (HP:0001355)1.65695170
156Labial hypoplasia (HP:0000066)1.64858706
157Impaired smooth pursuit (HP:0007772)1.64530845
158Volvulus (HP:0002580)1.64372800
159Truncal obesity (HP:0001956)1.64035572
160Specific learning disability (HP:0001328)1.63104057
161Abnormal biliary tract physiology (HP:0012439)1.62732091
162Bile duct proliferation (HP:0001408)1.62732091
163Hypoplastic labia majora (HP:0000059)1.62607834
164Prominent nasal bridge (HP:0000426)1.60267397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.91343636
2TNIK4.72901726
3NTRK33.63790833
4EPHA43.37962997
5ACVR1B3.02944102
6CASK2.79269295
7MAP3K42.57082911
8MARK12.48394138
9MAP2K72.29469872
10WNK32.18943317
11MAPK132.14298119
12TAOK31.96900351
13NTRK21.90482951
14PAK61.84346092
15MAP3K91.84080865
16MAP4K21.81144555
17FES1.67135382
18GRK11.67046316
19PRPF4B1.65190390
20AKT31.62824636
21STK391.59224800
22MINK11.55780753
23INSRR1.53774677
24CAMK1G1.51784256
25MAP2K41.46413369
26OXSR11.41123230
27RIPK41.36260069
28PNCK1.33307957
29NEK61.31405832
30PLK21.27409123
31MAP3K131.23590048
32SGK4941.22670252
33SGK2231.22670252
34SGK21.21562552
35CDK51.20963778
36IRAK21.16720788
37WNK41.16487865
38TYRO31.14390529
39TXK1.14269278
40NLK1.10567579
41SIK31.10039544
42EPHB11.09991059
43CAMK2A1.07941531
44KSR11.06438242
45ADRBK11.04095794
46MAP3K61.03389628
47UHMK11.03244845
48PRKD31.02519623
49STK381.00478237
50WNK10.98761088
51MAP3K120.96805275
52SIK20.95355659
53OBSCN0.94566666
54STK38L0.94545648
55MARK20.94005740
56DMPK0.93738322
57PIK3CA0.93201123
58FGR0.92079034
59SGK10.91263810
60PIK3CG0.89635885
61PRKCG0.89203926
62PKN10.88486008
63TEC0.88337734
64PRKD20.87707612
65BCR0.86817693
66CAMK1D0.86485875
67NTRK10.85537614
68DAPK20.85475009
69BMPR20.84872788
70GRK50.84095117
71PRKCE0.83681971
72YES10.83005200
73CAMKK20.82648586
74CAMK2B0.81754295
75TGFBR10.81537299
76NUAK10.80997296
77CAMK10.80212145
78ERBB30.80019975
79PRKCH0.76443278
80CDK30.75223001
81SGK30.74599321
82TLK10.73815230
83CAMKK10.73761258
84CSNK1A1L0.73066800
85DYRK1A0.72942417
86FGFR20.72157171
87CAMK2D0.71793869
88CDK190.69799960
89STK110.68937826
90TAF10.65254238
91EPHA30.63590896
92GRK70.63564862
93PINK10.62735697
94CSNK1G10.62510149
95CSNK1G20.61971330
96PHKG20.60863325
97PHKG10.60863325
98MKNK20.60461211
99PTK2B0.60176588
100DYRK20.59588476
101BRD40.58404300
102LATS10.57384257
103STK30.57301456
104TRPM70.56413152
105MUSK0.56282750
106PRKG10.55730196
107ADRBK20.54638977
108ICK0.54265267
109ZAK0.53897993
110MELK0.53896487
111FYN0.52592340
112FER0.52132258
113BRSK20.51993602
114TRIM280.51488725
115CAMK40.51168500
116MAPK100.50653319
117PRKAA20.50356343
118ROCK20.48055509
119ROCK10.47413208
120RPS6KA30.47051952
121BMPR1B0.46899025
122MAPK70.45873893
123RET0.45080301
124CSNK1D0.44234758
125PAK30.44046048
126IRAK10.43607417
127PRKAA10.43345182
128PRKCQ0.42432564
129TAOK10.42391195
130KSR20.41549435
131TIE10.41460584
132ERBB20.40588821
133PRKACA0.39312700
134KIT0.39131501
135MAP3K70.37647656
136SYK0.37554244
137PRKCB0.37497646
138FLT30.37102880
139TNK20.36666867
140CDC42BPA0.36189434
141CSNK1G30.34843521
142PRKCZ0.33249286
143CHUK0.30539065
144CSNK1A10.30460217

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.58366613
2Glutamatergic synapse_Homo sapiens_hsa047242.60447706
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59976934
4Morphine addiction_Homo sapiens_hsa050322.40497758
5GABAergic synapse_Homo sapiens_hsa047272.40468515
6Circadian entrainment_Homo sapiens_hsa047132.39275824
7Synaptic vesicle cycle_Homo sapiens_hsa047212.30854462
8Serotonergic synapse_Homo sapiens_hsa047262.12631014
9Long-term potentiation_Homo sapiens_hsa047202.08266152
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00083596
11Olfactory transduction_Homo sapiens_hsa047401.99116565
12Amphetamine addiction_Homo sapiens_hsa050311.95416585
13Nitrogen metabolism_Homo sapiens_hsa009101.90962630
14Dopaminergic synapse_Homo sapiens_hsa047281.89563262
15Linoleic acid metabolism_Homo sapiens_hsa005911.88295319
16Cholinergic synapse_Homo sapiens_hsa047251.87104558
17Long-term depression_Homo sapiens_hsa047301.86837226
18Salivary secretion_Homo sapiens_hsa049701.83772966
19ABC transporters_Homo sapiens_hsa020101.83285388
20Insulin secretion_Homo sapiens_hsa049111.79668420
21Butanoate metabolism_Homo sapiens_hsa006501.77961444
22Taste transduction_Homo sapiens_hsa047421.71387910
23Axon guidance_Homo sapiens_hsa043601.68798382
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61143700
25Renin secretion_Homo sapiens_hsa049241.57224146
26Phototransduction_Homo sapiens_hsa047441.53390430
27Oxytocin signaling pathway_Homo sapiens_hsa049211.52103600
28Calcium signaling pathway_Homo sapiens_hsa040201.49838800
29Collecting duct acid secretion_Homo sapiens_hsa049661.46890487
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.46216220
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45187737
32Cocaine addiction_Homo sapiens_hsa050301.42439969
33Gastric acid secretion_Homo sapiens_hsa049711.36936300
34Selenocompound metabolism_Homo sapiens_hsa004501.36257484
35GnRH signaling pathway_Homo sapiens_hsa049121.34769552
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34540388
37cAMP signaling pathway_Homo sapiens_hsa040241.28071201
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27279955
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24396130
40Type II diabetes mellitus_Homo sapiens_hsa049301.20337531
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17101973
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14182759
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12191270
44Basal transcription factors_Homo sapiens_hsa030221.12082083
45Dorso-ventral axis formation_Homo sapiens_hsa043201.07390529
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.07005243
47Tryptophan metabolism_Homo sapiens_hsa003801.06061505
48Choline metabolism in cancer_Homo sapiens_hsa052311.04531124
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03689893
50Lysine degradation_Homo sapiens_hsa003101.03513458
51Ether lipid metabolism_Homo sapiens_hsa005651.03378315
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.02272966
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.01579649
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00834646
55Steroid biosynthesis_Homo sapiens_hsa001001.00509685
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00059002
57ErbB signaling pathway_Homo sapiens_hsa040120.99574804
58Gap junction_Homo sapiens_hsa045400.99093932
59Fanconi anemia pathway_Homo sapiens_hsa034600.99088836
60Circadian rhythm_Homo sapiens_hsa047100.94096023
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91242263
62Melanogenesis_Homo sapiens_hsa049160.89783446
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89010339
64Ovarian steroidogenesis_Homo sapiens_hsa049130.88148472
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.87267460
66Regulation of autophagy_Homo sapiens_hsa041400.86995289
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83594287
68Glycerolipid metabolism_Homo sapiens_hsa005610.82511271
69Inositol phosphate metabolism_Homo sapiens_hsa005620.81300060
70Glioma_Homo sapiens_hsa052140.81241553
71Ras signaling pathway_Homo sapiens_hsa040140.80924035
72MAPK signaling pathway_Homo sapiens_hsa040100.80384341
73Estrogen signaling pathway_Homo sapiens_hsa049150.79598523
74Caffeine metabolism_Homo sapiens_hsa002320.79100903
75Pancreatic secretion_Homo sapiens_hsa049720.78590564
76Dilated cardiomyopathy_Homo sapiens_hsa054140.78458068
77Homologous recombination_Homo sapiens_hsa034400.78428013
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76167169
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74384497
80Renal cell carcinoma_Homo sapiens_hsa052110.71827578
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71694652
82Propanoate metabolism_Homo sapiens_hsa006400.71554252
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71479885
84Vibrio cholerae infection_Homo sapiens_hsa051100.71298898
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.70844153
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69226570
87Rheumatoid arthritis_Homo sapiens_hsa053230.69080563
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68856456
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68801344
90Wnt signaling pathway_Homo sapiens_hsa043100.67888430
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65812989
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65249096
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64984709
94Sphingolipid metabolism_Homo sapiens_hsa006000.63971287
95FoxO signaling pathway_Homo sapiens_hsa040680.61371734
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59765710
97TGF-beta signaling pathway_Homo sapiens_hsa043500.59527006
98Cardiac muscle contraction_Homo sapiens_hsa042600.58822360
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58343832
100RNA degradation_Homo sapiens_hsa030180.58302523
101Rap1 signaling pathway_Homo sapiens_hsa040150.58148643
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57882797
103Retinol metabolism_Homo sapiens_hsa008300.57409186
104African trypanosomiasis_Homo sapiens_hsa051430.57366428
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56277428
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54983767
107Thyroid hormone synthesis_Homo sapiens_hsa049180.53323344
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53090641
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51310556
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50240879
111Peroxisome_Homo sapiens_hsa041460.48957954
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48026944
113Chemical carcinogenesis_Homo sapiens_hsa052040.47955593
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44040254
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43817724
116Non-homologous end-joining_Homo sapiens_hsa034500.43419330
117Oocyte meiosis_Homo sapiens_hsa041140.43173291
118Chemokine signaling pathway_Homo sapiens_hsa040620.41896138
119Arachidonic acid metabolism_Homo sapiens_hsa005900.41864050
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41233489
121VEGF signaling pathway_Homo sapiens_hsa043700.39481209
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38672434
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.38187729
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.37756148
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37481977
126Melanoma_Homo sapiens_hsa052180.36387454
127Alcoholism_Homo sapiens_hsa050340.36308273
128beta-Alanine metabolism_Homo sapiens_hsa004100.36113283
129Platelet activation_Homo sapiens_hsa046110.35421162
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.34558622
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34404005
132Type I diabetes mellitus_Homo sapiens_hsa049400.34212522
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34210515
134Fatty acid biosynthesis_Homo sapiens_hsa000610.33102946
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32910266
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32401090
137Endocytosis_Homo sapiens_hsa041440.31985923
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.31616320
139Hedgehog signaling pathway_Homo sapiens_hsa043400.30304577

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