MBIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)4.25479554
2central nervous system myelination (GO:0022010)3.89512493
3axon ensheathment in central nervous system (GO:0032291)3.89512493
4proteasome assembly (GO:0043248)3.79933071
5CENP-A containing nucleosome assembly (GO:0034080)3.74019319
67-methylguanosine mRNA capping (GO:0006370)3.73354857
7RNA capping (GO:0036260)3.73014508
87-methylguanosine RNA capping (GO:0009452)3.73014508
9negative regulation of DNA-dependent DNA replication (GO:2000104)3.63685364
10establishment of integrated proviral latency (GO:0075713)3.61227490
11regulation of DNA endoreduplication (GO:0032875)3.55645338
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52038983
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52038983
14limb bud formation (GO:0060174)3.46160714
15chromatin remodeling at centromere (GO:0031055)3.46019448
16cullin deneddylation (GO:0010388)3.44164439
17protein deneddylation (GO:0000338)3.38726342
18intra-S DNA damage checkpoint (GO:0031573)3.34634518
19intraciliary transport (GO:0042073)3.32683804
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32052145
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26479542
22somite development (GO:0061053)3.26121348
23negative regulation of DNA recombination (GO:0045910)3.24579267
24mitotic metaphase plate congression (GO:0007080)3.21887180
25replication fork processing (GO:0031297)3.21775337
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21171582
27anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16896216
28DNA ligation (GO:0006266)3.12578633
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12388020
30establishment of viral latency (GO:0019043)3.12086656
31centriole replication (GO:0007099)3.11996634
32DNA replication-dependent nucleosome assembly (GO:0006335)3.09497984
33DNA replication-dependent nucleosome organization (GO:0034723)3.09497984
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09299005
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09068310
36negative regulation of ligase activity (GO:0051352)3.09068310
37piRNA metabolic process (GO:0034587)3.07467618
38transcription-coupled nucleotide-excision repair (GO:0006283)3.05310100
39kinetochore organization (GO:0051383)3.05067651
40resolution of meiotic recombination intermediates (GO:0000712)3.04746507
41protein neddylation (GO:0045116)3.04038560
42attachment of spindle microtubules to kinetochore (GO:0008608)3.03978423
43termination of RNA polymerase III transcription (GO:0006386)3.03693172
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.03693172
45kinetochore assembly (GO:0051382)3.01820220
46DNA replication-independent nucleosome organization (GO:0034724)3.01433876
47DNA replication-independent nucleosome assembly (GO:0006336)3.01433876
48respiratory chain complex IV assembly (GO:0008535)3.00082310
49DNA damage response, detection of DNA damage (GO:0042769)2.99947538
50DNA strand elongation (GO:0022616)2.98289426
51regulation of meiosis I (GO:0060631)2.96653820
52transcription elongation from RNA polymerase II promoter (GO:0006368)2.93123086
53telomere maintenance via telomerase (GO:0007004)2.92980998
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92097034
55histone exchange (GO:0043486)2.91993019
56regulation of nuclear cell cycle DNA replication (GO:0033262)2.91084673
57DNA strand elongation involved in DNA replication (GO:0006271)2.90717531
58ribosome assembly (GO:0042255)2.88403385
59protein-cofactor linkage (GO:0018065)2.87188946
60metaphase plate congression (GO:0051310)2.87011207
61viral mRNA export from host cell nucleus (GO:0046784)2.86849324
62establishment of chromosome localization (GO:0051303)2.86453069
63protein localization to kinetochore (GO:0034501)2.85306514
64forebrain neuron differentiation (GO:0021879)2.82766241
65spliceosomal complex assembly (GO:0000245)2.82708166
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82696374
67RNA-dependent DNA replication (GO:0006278)2.82155331
68nonmotile primary cilium assembly (GO:0035058)2.81419875
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80656634
70telomere maintenance via telomere lengthening (GO:0010833)2.80566018
71negative regulation of mitosis (GO:0045839)2.79975657
72maturation of 5.8S rRNA (GO:0000460)2.79151268
73DNA replication checkpoint (GO:0000076)2.76849231
74organelle disassembly (GO:1903008)2.76778075
75spliceosomal snRNP assembly (GO:0000387)2.76506907
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76472790
77cilium morphogenesis (GO:0060271)2.76148291
78DNA double-strand break processing (GO:0000729)2.75887779
79somatic hypermutation of immunoglobulin genes (GO:0016446)2.75812680
80somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75812680
81neural tube formation (GO:0001841)2.75277588
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75074867
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75074867
84spindle checkpoint (GO:0031577)2.74707209
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74247460
86negative regulation of sister chromatid segregation (GO:0033046)2.74247460
87negative regulation of mitotic sister chromatid separation (GO:2000816)2.74247460
88negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74247460
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73856969
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73856969
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73856969
92mitotic spindle assembly checkpoint (GO:0007094)2.72859645
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72764799
94peptidyl-histidine modification (GO:0018202)2.72563212
95purine nucleobase biosynthetic process (GO:0009113)2.72451966
96protein K11-linked ubiquitination (GO:0070979)2.72050583
97histone H2A acetylation (GO:0043968)2.71954235
98positive regulation of viral transcription (GO:0050434)2.71543856
99spindle assembly checkpoint (GO:0071173)2.71111648
100positive regulation of mRNA processing (GO:0050685)2.69925475
101negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68790107
102histone mRNA metabolic process (GO:0008334)2.68306102
103chaperone-mediated protein transport (GO:0072321)2.67691752
104formation of translation preinitiation complex (GO:0001731)2.67398472
105microtubule depolymerization (GO:0007019)2.67077614
106negative regulation of chromosome segregation (GO:0051985)2.66084929
107signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65372647
108signal transduction involved in DNA damage checkpoint (GO:0072422)2.65372647
109signal transduction involved in cell cycle checkpoint (GO:0072395)2.65354167
110reciprocal meiotic recombination (GO:0007131)2.65012494
111reciprocal DNA recombination (GO:0035825)2.65012494
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64965985
113transcription elongation from RNA polymerase I promoter (GO:0006362)2.64755882
114DNA-templated transcription, elongation (GO:0006354)2.63531407
115telomere maintenance via semi-conservative replication (GO:0032201)2.62362874
116olfactory bulb development (GO:0021772)2.62127978
117regulation of development, heterochronic (GO:0040034)2.61157779
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59400674
119regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59400674
120positive regulation of ligase activity (GO:0051351)2.59320213
121mitotic spindle checkpoint (GO:0071174)2.58352702
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.57336066
123establishment of protein localization to mitochondrial membrane (GO:0090151)2.57171044
124telomere maintenance via recombination (GO:0000722)2.56877057
125non-recombinational repair (GO:0000726)2.56390190
126double-strand break repair via nonhomologous end joining (GO:0006303)2.56390190
127base-excision repair, AP site formation (GO:0006285)2.54590654
128DNA replication initiation (GO:0006270)2.54219774
129DNA deamination (GO:0045006)2.54115806
130sequestering of actin monomers (GO:0042989)2.53758475
131DNA catabolic process, exonucleolytic (GO:0000738)2.52206052
132regulation of sister chromatid segregation (GO:0033045)2.51769346
133regulation of mitotic sister chromatid separation (GO:0010965)2.51769346
134regulation of mitotic sister chromatid segregation (GO:0033047)2.51769346
135regulation of helicase activity (GO:0051095)2.51223541
136mitotic sister chromatid segregation (GO:0000070)2.50560125
137presynaptic membrane assembly (GO:0097105)2.50289398
138rRNA modification (GO:0000154)2.50284209
139termination of RNA polymerase I transcription (GO:0006363)2.50274390
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.50170410
141NADH dehydrogenase complex assembly (GO:0010257)2.50170410
142mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50170410
143regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.49681209
144regulation of mitotic spindle checkpoint (GO:1903504)2.49681209
145sister chromatid segregation (GO:0000819)2.49554085
146positive regulation of mRNA metabolic process (GO:1903313)2.48412895
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48100717
148nucleobase biosynthetic process (GO:0046112)2.47792086
149pseudouridine synthesis (GO:0001522)2.47423574
150mismatch repair (GO:0006298)2.47322447
151maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47156396
152water-soluble vitamin biosynthetic process (GO:0042364)2.47124945
153response to pheromone (GO:0019236)2.46917771
154mitotic G2/M transition checkpoint (GO:0044818)2.44409165
155regulation of timing of cell differentiation (GO:0048505)2.44256453
156positive regulation of mitochondrial fission (GO:0090141)2.43938153
157sister chromatid cohesion (GO:0007062)2.43835170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.12462735
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13400948
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.56425508
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.44804959
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25652970
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23458359
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.15049191
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93031487
9* ZNF274_21170338_ChIP-Seq_K562_Hela2.91161042
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87471633
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.85792353
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85578896
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.84872909
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74763912
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64627091
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40710654
17VDR_23849224_ChIP-Seq_CD4+_Human2.35747122
18IGF1R_20145208_ChIP-Seq_DFB_Human2.31054726
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30524299
20YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28650761
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28563174
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28488200
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24042999
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19428195
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16895655
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.12352419
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11917253
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11115567
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09755220
30ELK1_19687146_ChIP-ChIP_HELA_Human2.07231764
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.03222951
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97832392
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94129592
34P300_19829295_ChIP-Seq_ESCs_Human1.92113704
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91970759
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91844558
37DCP1A_22483619_ChIP-Seq_HELA_Human1.89504737
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86663175
39FOXP3_21729870_ChIP-Seq_TREG_Human1.83568464
40XRN2_22483619_ChIP-Seq_HELA_Human1.83169797
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81085584
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74267914
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73983263
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73190004
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.72720253
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.68086268
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67543648
48GABP_19822575_ChIP-Seq_HepG2_Human1.66727783
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66070635
50* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63936671
51FUS_26573619_Chip-Seq_HEK293_Human1.58129383
52TTF2_22483619_ChIP-Seq_HELA_Human1.57908899
53* EWS_26573619_Chip-Seq_HEK293_Human1.57031753
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56164071
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55286185
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52549777
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51937817
58AR_21909140_ChIP-Seq_LNCAP_Human1.49728815
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48619887
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40606781
61* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.40049399
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39535023
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39515153
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38742891
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38088776
66* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36286466
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34581852
68* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33218230
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31689095
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.31084285
71EZH2_22144423_ChIP-Seq_EOC_Human1.30317295
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.30042468
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29890830
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.28922308
75* ER_23166858_ChIP-Seq_MCF-7_Human1.25799241
76IRF1_19129219_ChIP-ChIP_H3396_Human1.25222397
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25211110
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23940451
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23535910
80CBP_20019798_ChIP-Seq_JUKART_Human1.23535910
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23262438
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.23004719
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.18653849
84* SMAD4_21799915_ChIP-Seq_A2780_Human1.18494516
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17052346
86* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15785924
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15658505
88* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14271317
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14029211
90* PIAS1_25552417_ChIP-Seq_VCAP_Human1.12955298
91* SMAD3_21741376_ChIP-Seq_EPCs_Human1.12310778
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12161787
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11797942
94AR_25329375_ChIP-Seq_VCAP_Human1.10827539
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10648751
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.10373277
97TCF4_22108803_ChIP-Seq_LS180_Human1.09939211
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09148315
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.07856709
100MYC_18940864_ChIP-ChIP_HL60_Human1.07854944
101* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06151000
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05052589
103GBX2_23144817_ChIP-Seq_PC3_Human1.04934721
104SOX2_19829295_ChIP-Seq_ESCs_Human1.03462622
105NANOG_19829295_ChIP-Seq_ESCs_Human1.03462622
106STAT3_23295773_ChIP-Seq_U87_Human1.03313663
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.02761263
108VDR_22108803_ChIP-Seq_LS180_Human1.02480064
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01865298
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01134208
111SOX17_20123909_ChIP-Seq_XEN_Mouse1.01061874
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99099595
113BCAT_22108803_ChIP-Seq_LS180_Human0.98584505
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98539473
115TP53_22573176_ChIP-Seq_HFKS_Human0.98422591
116* RUNX2_22187159_ChIP-Seq_PCA_Human0.98183415
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97673803
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97063386
119* TAL1_26923725_Chip-Seq_HPCs_Mouse0.97003963
120CRX_20693478_ChIP-Seq_RETINA_Mouse0.96929393
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95780290
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95468181
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94587578
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94195882
125KDM5A_27292631_Chip-Seq_BREAST_Human0.93219089
126ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92768406
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92595668
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92291659
129RNF2_27304074_Chip-Seq_NSC_Mouse0.91666567
130TAF15_26573619_Chip-Seq_HEK293_Human0.89615179
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.88556368
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87372843
133CIITA_25753668_ChIP-Seq_RAJI_Human0.86426043
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86323119
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86072531
136FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84916505
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84679211
138FLI1_27457419_Chip-Seq_LIVER_Mouse0.84639660
139NANOG_16153702_ChIP-ChIP_HESCs_Human0.84189600
140* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81068037
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80593814
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75448462
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74132779
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74043762
145SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.73683202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.53254826
2MP0000566_synostosis3.46090702
3MP0010094_abnormal_chromosome_stability2.87647299
4MP0003693_abnormal_embryo_hatching2.83299227
5MP0008995_early_reproductive_senescence2.63104072
6MP0001529_abnormal_vocalization2.53975620
7MP0003787_abnormal_imprinting2.52511442
8MP0004957_abnormal_blastocyst_morpholog2.43622856
9MP0001984_abnormal_olfaction2.38433142
10MP0008877_abnormal_DNA_methylation2.38339643
11MP0006292_abnormal_olfactory_placode2.33970656
12MP0003111_abnormal_nucleus_morphology2.33353896
13MP0005394_taste/olfaction_phenotype2.31329185
14MP0005499_abnormal_olfactory_system2.31329185
15MP0008058_abnormal_DNA_repair2.30432060
16MP0003077_abnormal_cell_cycle2.26170456
17MP0001188_hyperpigmentation2.20881921
18MP0003121_genomic_imprinting2.18458701
19MP0002234_abnormal_pharynx_morphology2.17983287
20MP0005171_absent_coat_pigmentation2.12190560
21MP0003786_premature_aging2.04717100
22MP0008260_abnormal_autophagy2.03982926
23MP0003718_maternal_effect1.98815994
24MP0003123_paternal_imprinting1.95186081
25MP0008057_abnormal_DNA_replication1.94147273
26MP0008932_abnormal_embryonic_tissue1.89491084
27MP0003950_abnormal_plasma_membrane1.88247909
28MP0004782_abnormal_surfactant_physiolog1.84030206
29MP0002233_abnormal_nose_morphology1.80095455
30MP0008007_abnormal_cellular_replicative1.77271396
31MP0004133_heterotaxia1.61489687
32MP0003195_calcinosis1.53748392
33MP0005187_abnormal_penis_morphology1.52831643
34MP0000015_abnormal_ear_pigmentation1.52597623
35MP0001485_abnormal_pinna_reflex1.46477000
36MP0002938_white_spotting1.45564222
37MP0000647_abnormal_sebaceous_gland1.45554887
38MP0002277_abnormal_respiratory_mucosa1.43192706
39MP0009697_abnormal_copulation1.42547108
40MP0001905_abnormal_dopamine_level1.39917606
41MP0010030_abnormal_orbit_morphology1.39397096
42MP0000778_abnormal_nervous_system1.33771472
43MP0003136_yellow_coat_color1.30749555
44MP0003567_abnormal_fetal_cardiomyocyte1.27996815
45MP0001177_atelectasis1.27014132
46MP0002102_abnormal_ear_morphology1.24749959
47MP0001730_embryonic_growth_arrest1.24299493
48MP0003183_abnormal_peptide_metabolism1.23904237
49MP0003938_abnormal_ear_development1.18763344
50MP0003937_abnormal_limbs/digits/tail_de1.16509426
51MP0001293_anophthalmia1.14397554
52MP0004742_abnormal_vestibular_system1.13542521
53MP0002653_abnormal_ependyma_morphology1.12758036
54MP0005408_hypopigmentation1.10731350
55MP0003122_maternal_imprinting1.10423914
56MP0003698_abnormal_male_reproductive1.09077743
57MP0002132_abnormal_respiratory_system1.05646175
58MP0002210_abnormal_sex_determination1.04560682
59MP0006072_abnormal_retinal_apoptosis1.03462020
60MP0002282_abnormal_trachea_morphology1.03346869
61MP0000427_abnormal_hair_cycle1.01668550
62MP0000920_abnormal_myelination1.01517712
63MP0005551_abnormal_eye_electrophysiolog0.99837461
64MP0005423_abnormal_somatic_nervous0.98733102
65MP0000350_abnormal_cell_proliferation0.98061039
66MP0004215_abnormal_myocardial_fiber0.97934028
67MP0005391_vision/eye_phenotype0.97334628
68MP0002751_abnormal_autonomic_nervous0.96831328
69MP0001764_abnormal_homeostasis0.95998674
70MP0005253_abnormal_eye_physiology0.94684907
71MP0002736_abnormal_nociception_after0.93042917
72MP0003890_abnormal_embryonic-extraembry0.92258270
73MP0003941_abnormal_skin_development0.92171741
74MP0002272_abnormal_nervous_system0.91071132
75MP0009046_muscle_twitch0.90735725
76MP0005388_respiratory_system_phenotype0.90489977
77MP0002133_abnormal_respiratory_system0.90489977
78MP0001119_abnormal_female_reproductive0.89358315
79MP0005389_reproductive_system_phenotype0.89221672
80MP0002249_abnormal_larynx_morphology0.88700536
81MP0002697_abnormal_eye_size0.88445309
82MP0000631_abnormal_neuroendocrine_gland0.87859551
83MP0005075_abnormal_melanosome_morpholog0.87188031
84MP0000462_abnormal_digestive_system0.87118642
85MP0000383_abnormal_hair_follicle0.86651178
86MP0004134_abnormal_chest_morphology0.86285381
87MP0003315_abnormal_perineum_morphology0.86238700
88MP0000372_irregular_coat_pigmentation0.85951196
89MP0005084_abnormal_gallbladder_morpholo0.85035625
90MP0004885_abnormal_endolymph0.84847936
91MP0002396_abnormal_hematopoietic_system0.84702163
92MP0005395_other_phenotype0.84425080
93MP0001145_abnormal_male_reproductive0.84193949
94MP0005645_abnormal_hypothalamus_physiol0.83954048
95MP0000681_abnormal_thyroid_gland0.82837886
96MP0005195_abnormal_posterior_eye0.82544279
97MP0001286_abnormal_eye_development0.82082323
98MP0002557_abnormal_social/conspecific_i0.81952459
99MP0005646_abnormal_pituitary_gland0.81700603
100MP0004142_abnormal_muscle_tone0.81258082
101MP0001929_abnormal_gametogenesis0.80802398
102MP0000049_abnormal_middle_ear0.79921796
103MP0001963_abnormal_hearing_physiology0.78897973
104MP0001440_abnormal_grooming_behavior0.78643388
105MP0002160_abnormal_reproductive_system0.78597859
106MP0002085_abnormal_embryonic_tissue0.77824375
107MP0000026_abnormal_inner_ear0.77655958
108MP0002095_abnormal_skin_pigmentation0.77572304
109MP0002638_abnormal_pupillary_reflex0.77417679
110MP0000313_abnormal_cell_death0.77338449
111MP0005409_darkened_coat_color0.77265984
112MP0005647_abnormal_sex_gland0.76838650
113MP0000537_abnormal_urethra_morphology0.76759944
114MP0006035_abnormal_mitochondrial_morpho0.76004686
115MP0004043_abnormal_pH_regulation0.75814332
116MP0002752_abnormal_somatic_nervous0.75353565
117MP0002084_abnormal_developmental_patter0.74866690
118MP0003935_abnormal_craniofacial_develop0.74828014
119MP0001270_distended_abdomen0.74753813
120MP0001697_abnormal_embryo_size0.74523123
121MP0003119_abnormal_digestive_system0.73868993
122MP0008004_abnormal_stomach_pH0.73708885
123MP0004924_abnormal_behavior0.72156608
124MP0005386_behavior/neurological_phenoty0.72156608
125MP0001986_abnormal_taste_sensitivity0.71704836
126MP0000653_abnormal_sex_gland0.71474520
127MP0001958_emphysema0.71104493
128MP0001968_abnormal_touch/_nociception0.70769327
129MP0001324_abnormal_eye_pigmentation0.70626517
130MP0004197_abnormal_fetal_growth/weight/0.70474104
131MP0001919_abnormal_reproductive_system0.69915583
132MP0006276_abnormal_autonomic_nervous0.66378741
133MP0001486_abnormal_startle_reflex0.66345530
134MP0004147_increased_porphyrin_level0.66113917
135MP0003861_abnormal_nervous_system0.65962810
136MP0002064_seizures0.65283978
137MP0008789_abnormal_olfactory_epithelium0.64403832
138MP0002163_abnormal_gland_morphology0.64026219
139MP0002177_abnormal_outer_ear0.62589146
140MP0001502_abnormal_circadian_rhythm0.62498691
141MP0003755_abnormal_palate_morphology0.60972198

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)3.67723800
2Birth length less than 3rd percentile (HP:0003561)3.53621254
3Abnormality of the labia minora (HP:0012880)3.04791243
4True hermaphroditism (HP:0010459)2.96018150
5Volvulus (HP:0002580)2.93821667
6Abnormal hair whorl (HP:0010721)2.90415038
7Supernumerary spleens (HP:0009799)2.66074550
8Aplasia/Hypoplasia of the uvula (HP:0010293)2.65182559
9Medial flaring of the eyebrow (HP:0010747)2.62963334
10Pancreatic fibrosis (HP:0100732)2.62907835
11Hyperglycinemia (HP:0002154)2.56766074
12Abnormal lung lobation (HP:0002101)2.56509474
13Gait imbalance (HP:0002141)2.55044466
14Nephrogenic diabetes insipidus (HP:0009806)2.53885903
15Nephronophthisis (HP:0000090)2.52180746
16Congenital primary aphakia (HP:0007707)2.51161133
17Abnormality of chromosome stability (HP:0003220)2.50906920
18Hyperventilation (HP:0002883)2.49331522
19Vaginal atresia (HP:0000148)2.48655412
20Pancreatic cysts (HP:0001737)2.47791295
21Absent radius (HP:0003974)2.44923770
22Adrenal hypoplasia (HP:0000835)2.44217606
23Split foot (HP:0001839)2.44013007
24Preaxial hand polydactyly (HP:0001177)2.43365855
25Genital tract atresia (HP:0001827)2.41863806
26CNS hypomyelination (HP:0003429)2.38521739
27Oligodactyly (hands) (HP:0001180)2.37112381
28Gonadotropin excess (HP:0000837)2.36102670
29Short tibia (HP:0005736)2.35352704
30Aplasia involving forearm bones (HP:0009822)2.35156803
31Absent forearm bone (HP:0003953)2.35156803
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.35060460
33Septo-optic dysplasia (HP:0100842)2.32919710
34Breast hypoplasia (HP:0003187)2.29713011
35Stenosis of the external auditory canal (HP:0000402)2.27008903
36Patellar aplasia (HP:0006443)2.24001575
37Medulloblastoma (HP:0002885)2.22899904
38Intestinal atresia (HP:0011100)2.22335921
39Anencephaly (HP:0002323)2.21435635
40Abnormality of the nasolacrimal system (HP:0000614)2.21098771
41Abnormality of the fetal cardiovascular system (HP:0010948)2.19893101
42Abnormal umbilical cord blood vessels (HP:0011403)2.19893101
43Single umbilical artery (HP:0001195)2.19893101
44Premature graying of hair (HP:0002216)2.19724587
45Abnormal biliary tract physiology (HP:0012439)2.19610988
46Bile duct proliferation (HP:0001408)2.19610988
47Absent septum pellucidum (HP:0001331)2.18599514
48Alacrima (HP:0000522)2.17572912
493-Methylglutaconic aciduria (HP:0003535)2.17191695
50Abnormality of the septum pellucidum (HP:0007375)2.17075278
51Optic nerve coloboma (HP:0000588)2.16439954
52Rough bone trabeculation (HP:0100670)2.16399626
53Morphological abnormality of the inner ear (HP:0011390)2.15870698
54Median cleft lip (HP:0000161)2.15693357
55Tubulointerstitial nephritis (HP:0001970)2.14882605
56Abnormality of serine family amino acid metabolism (HP:0010894)2.13620333
57Abnormality of glycine metabolism (HP:0010895)2.13620333
58Methylmalonic acidemia (HP:0002912)2.13260270
59Poor coordination (HP:0002370)2.12497067
60Neonatal respiratory distress (HP:0002643)2.09077156
61Hyperglycinuria (HP:0003108)2.07996992
62Abnormality of the lacrimal duct (HP:0011481)2.07716563
63Postaxial hand polydactyly (HP:0001162)2.06296209
64Nephroblastoma (Wilms tumor) (HP:0002667)2.05649712
65Abnormality of the duodenum (HP:0002246)2.05409400
66Abnormality of incisor morphology (HP:0011063)2.05249365
67Aplasia/Hypoplasia of the patella (HP:0006498)2.04952111
68Lipid accumulation in hepatocytes (HP:0006561)2.04346172
69Chromsome breakage (HP:0040012)2.04299606
70Abnormality of the renal medulla (HP:0100957)2.04028076
71Acute necrotizing encephalopathy (HP:0006965)2.01887335
72Neoplasm of the oral cavity (HP:0100649)2.01255857
73Meckel diverticulum (HP:0002245)2.01090471
74Glioma (HP:0009733)2.00718864
75Nasolacrimal duct obstruction (HP:0000579)2.00402957
76Increased serum pyruvate (HP:0003542)1.99667198
77Abnormality of glycolysis (HP:0004366)1.99667198
78Embryonal renal neoplasm (HP:0011794)1.98217810
79Pendular nystagmus (HP:0012043)1.97236310
80Degeneration of anterior horn cells (HP:0002398)1.96707528
81Abnormality of the anterior horn cell (HP:0006802)1.96707528
82Cupped ear (HP:0000378)1.96262272
83Type 2 muscle fiber atrophy (HP:0003554)1.95875136
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92616927
85Rectal fistula (HP:0100590)1.91893961
86Rectovaginal fistula (HP:0000143)1.91893961
87Increased CSF lactate (HP:0002490)1.91891448
88Acute encephalopathy (HP:0006846)1.91299569
89Optic nerve hypoplasia (HP:0000609)1.90696984
90Increased hepatocellular lipid droplets (HP:0006565)1.90681371
91Partial duplication of thumb phalanx (HP:0009944)1.90631343
92Hypothermia (HP:0002045)1.89701161
93Abnormality of the ileum (HP:0001549)1.89320961
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.88100841
95Astigmatism (HP:0000483)1.87298893
96Anteriorly placed anus (HP:0001545)1.87253316
97Carpal bone hypoplasia (HP:0001498)1.86947928
98Duodenal stenosis (HP:0100867)1.86821265
99Small intestinal stenosis (HP:0012848)1.86821265
100Postnatal microcephaly (HP:0005484)1.85822501
101Abnormality of the clitoris (HP:0000056)1.85536898
102Progressive macrocephaly (HP:0004481)1.85389993
103Anophthalmia (HP:0000528)1.85114124
104Drooling (HP:0002307)1.85014179
105Bone marrow hypocellularity (HP:0005528)1.84488375
106Sclerocornea (HP:0000647)1.84444656
107Hepatoblastoma (HP:0002884)1.84250840
108Abnormality of the incisor (HP:0000676)1.84223633
109Decreased lacrimation (HP:0000633)1.83794004
110Abnormality of the preputium (HP:0100587)1.83388377
111Lissencephaly (HP:0001339)1.83264127
112Renal Fanconi syndrome (HP:0001994)1.82010864
113Thyroid-stimulating hormone excess (HP:0002925)1.81590857
114Absent speech (HP:0001344)1.81581208
115Progressive inability to walk (HP:0002505)1.80742157
116Esophageal atresia (HP:0002032)1.80518370
117Broad-based gait (HP:0002136)1.80450584
118Mitochondrial inheritance (HP:0001427)1.80253665
119Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79414952
120Scanning speech (HP:0002168)1.79230218
121Conical tooth (HP:0000698)1.78758726
122Chronic bronchitis (HP:0004469)1.78621970
123Dandy-Walker malformation (HP:0001305)1.77847373
124Abnormality of cochlea (HP:0000375)1.77146185
125Decreased testicular size (HP:0008734)1.77102611
126Abnormality of midbrain morphology (HP:0002418)1.77030101
127Molar tooth sign on MRI (HP:0002419)1.77030101
128Postaxial foot polydactyly (HP:0001830)1.76052077
129Abnormality of the columella (HP:0009929)1.75888393
130Duplicated collecting system (HP:0000081)1.75493826
131Aplastic anemia (HP:0001915)1.75278346
132Oligodactyly (HP:0012165)1.74881180
133Interstitial pulmonary disease (HP:0006530)1.74791383
134Selective tooth agenesis (HP:0001592)1.74208297
135Narrow forehead (HP:0000341)1.73887975
136Asplenia (HP:0001746)1.73315544
137Ectopic anus (HP:0004397)1.73050269
138Abnormality of chromosome segregation (HP:0002916)1.72395203
139Gastrointestinal atresia (HP:0002589)1.72297175
140Cellular immunodeficiency (HP:0005374)1.72013427
141Small hand (HP:0200055)1.71789388
142Hypoplastic pelvis (HP:0008839)1.71633267
143Sloping forehead (HP:0000340)1.70959865
144Abnormality of the astrocytes (HP:0100707)1.70729862
145Astrocytoma (HP:0009592)1.70729862
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70511529
147Aganglionic megacolon (HP:0002251)1.70027667
148Bifid tongue (HP:0010297)1.69861602
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69799229
150Cystic liver disease (HP:0006706)1.69501050
151Colon cancer (HP:0003003)1.69287741
152Clubbing of toes (HP:0100760)1.69095832
153Broad foot (HP:0001769)1.68069126
154Abnormality of serum amino acid levels (HP:0003112)1.68062623
155Broad alveolar ridges (HP:0000187)1.67489121
156Duplication of thumb phalanx (HP:0009942)1.67407721
157Abnormal trabecular bone morphology (HP:0100671)1.66693014
158Micropenis (HP:0000054)1.66495926
159Growth hormone deficiency (HP:0000824)1.66478699
160Triphalangeal thumb (HP:0001199)1.66431933
161Male pseudohermaphroditism (HP:0000037)1.66339755
162Tubulointerstitial fibrosis (HP:0005576)1.65972284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.83930287
2WNK33.17983759
3TRIM283.08257996
4MAP4K22.81075906
5CCNB12.73624140
6ACVR1B2.64109038
7BCR2.62162337
8WEE12.57971846
9MKNK12.57118255
10CASK2.54117626
11CDC72.25554145
12MKNK22.14825975
13BRSK22.12900088
14VRK12.10025746
15NEK61.98480512
16SRPK11.96350719
17STK161.95748909
18PBK1.88960636
19EIF2AK11.76668001
20VRK21.73662658
21CDK81.71768251
22CDK191.69588540
23OXSR11.65401273
24LIMK11.58083860
25EIF2AK31.58068109
26NEK11.55416069
27PLK31.52458124
28TSSK61.50679801
29FRK1.46508720
30STK391.42169731
31TNIK1.40882870
32MAP3K121.36272404
33PLK41.33662346
34BMPR1B1.30772381
35MARK11.30279526
36SIK31.28177465
37YES11.27222959
38CSNK1G31.26517443
39MAP3K41.26007898
40CDK31.17106607
41PLK11.15241418
42CHEK21.12504665
43STK38L1.11933596
44CLK11.11802075
45TTK1.05151191
46TESK21.03653154
47TAF11.03198413
48PRPF4B1.02691677
49DYRK21.02321926
50CSNK1A1L1.00461854
51EPHA40.99417496
52MAPK130.98713256
53AKT30.96489024
54INSRR0.96251285
55MST40.94769156
56MAP2K70.93043421
57TLK10.92768977
58NME10.92070546
59BRSK10.91137055
60CSNK1G10.87785060
61BRD40.87476945
62PINK10.87064457
63BRAF0.86160821
64RPS6KA50.83414921
65AURKB0.83026886
66PNCK0.81836622
67CSNK1G20.81659045
68ATR0.81374290
69MUSK0.78236272
70ERBB30.77807267
71PLK20.76862664
72NUAK10.75225766
73TXK0.75080652
74EIF2AK20.75048713
75AURKA0.74772809
76BCKDK0.73559379
77DYRK30.71006014
78NEK20.69466918
79STK30.68085328
80CDK70.66697506
81RPS6KA40.65247242
82MELK0.64057837
83PAK40.63735603
84UHMK10.63548122
85PASK0.62167829
86CAMK2B0.61625013
87CDK180.61459733
88RPS6KB20.59555394
89DAPK10.58259824
90CHEK10.55150567
91ROCK20.53988114
92CDK140.52141098
93STK240.51995116
94PDK20.51439280
95PKN10.51388326
96ZAK0.51198701
97CDK150.50790765
98TIE10.50381418
99TAOK30.50245877
100PAK30.49562638
101FGFR20.48270632
102CDK11A0.48153630
103CDK10.47877584
104GRK10.47270270
105CSNK2A10.47094958
106SGK4940.46402684
107SGK2230.46402684
108CSNK1E0.44572013
109STK100.44534871
110CSNK1D0.44045719
111FGFR10.43817648
112ATM0.43555933
113DYRK1A0.42711603
114CAMK2A0.42214903
115NEK90.42035033
116PIK3CA0.40151680
117CSNK2A20.39549029
118PAK10.38248428
119IRAK40.36354377
120CSNK1A10.36187729
121CDK90.36082367
122PRKCE0.35621555
123MAPKAPK50.34757472
124PRKCG0.34709270
125MAPK70.34584123
126CDK20.34540766
127MINK10.34068404
128NLK0.33595732
129PRKACB0.33157585
130TGFBR10.30834758
131MET0.29407706

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.66107310
2RNA polymerase_Homo sapiens_hsa030203.48146690
3Mismatch repair_Homo sapiens_hsa034303.17612575
4Basal transcription factors_Homo sapiens_hsa030223.08062589
5Spliceosome_Homo sapiens_hsa030403.07548395
6DNA replication_Homo sapiens_hsa030303.04774754
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76102115
8Non-homologous end-joining_Homo sapiens_hsa034502.71321783
9Homologous recombination_Homo sapiens_hsa034402.62043532
10Base excision repair_Homo sapiens_hsa034102.41665125
11Nucleotide excision repair_Homo sapiens_hsa034202.40356575
12Propanoate metabolism_Homo sapiens_hsa006402.35661466
13Cell cycle_Homo sapiens_hsa041102.28941558
14RNA transport_Homo sapiens_hsa030132.25377168
15RNA degradation_Homo sapiens_hsa030182.06281247
16Ribosome_Homo sapiens_hsa030102.01007284
17Fanconi anemia pathway_Homo sapiens_hsa034601.98135647
18Pyrimidine metabolism_Homo sapiens_hsa002401.93303897
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90430752
20Protein export_Homo sapiens_hsa030601.89137561
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82286805
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66347278
23Selenocompound metabolism_Homo sapiens_hsa004501.65003866
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54092947
25Ether lipid metabolism_Homo sapiens_hsa005651.51899374
26mRNA surveillance pathway_Homo sapiens_hsa030151.48652499
27Purine metabolism_Homo sapiens_hsa002301.48555178
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.48483622
29Butanoate metabolism_Homo sapiens_hsa006501.42305564
30Oxidative phosphorylation_Homo sapiens_hsa001901.37545348
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30734294
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28314898
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22677899
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17268858
35Folate biosynthesis_Homo sapiens_hsa007901.14845484
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13348691
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07085036
38Epstein-Barr virus infection_Homo sapiens_hsa051691.06216255
39Peroxisome_Homo sapiens_hsa041461.06108645
40Parkinsons disease_Homo sapiens_hsa050121.03311817
41Oocyte meiosis_Homo sapiens_hsa041141.01297117
42Vibrio cholerae infection_Homo sapiens_hsa051101.00239023
43Sphingolipid metabolism_Homo sapiens_hsa006000.99993064
44Huntingtons disease_Homo sapiens_hsa050160.99120272
45Vitamin B6 metabolism_Homo sapiens_hsa007500.97528877
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94973309
47Collecting duct acid secretion_Homo sapiens_hsa049660.94668787
48Nicotine addiction_Homo sapiens_hsa050330.90881832
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88328282
50Autoimmune thyroid disease_Homo sapiens_hsa053200.88158189
51Pyruvate metabolism_Homo sapiens_hsa006200.87379493
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84837588
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83844513
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.83322851
55Caffeine metabolism_Homo sapiens_hsa002320.82174018
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81556351
57beta-Alanine metabolism_Homo sapiens_hsa004100.79620600
58Rheumatoid arthritis_Homo sapiens_hsa053230.76774175
59Fatty acid degradation_Homo sapiens_hsa000710.76323301
60Fatty acid metabolism_Homo sapiens_hsa012120.76211305
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73752052
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71196705
63p53 signaling pathway_Homo sapiens_hsa041150.70771107
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69578978
65Nitrogen metabolism_Homo sapiens_hsa009100.69099963
66Regulation of autophagy_Homo sapiens_hsa041400.68862191
67Axon guidance_Homo sapiens_hsa043600.68284990
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66162666
69Circadian rhythm_Homo sapiens_hsa047100.65658527
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65295547
71Hedgehog signaling pathway_Homo sapiens_hsa043400.65293365
72Tryptophan metabolism_Homo sapiens_hsa003800.63297090
73Phototransduction_Homo sapiens_hsa047440.62777427
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62610628
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61915888
76Fatty acid elongation_Homo sapiens_hsa000620.61835351
77Alzheimers disease_Homo sapiens_hsa050100.61694452
78Retinol metabolism_Homo sapiens_hsa008300.61596718
79Primary immunodeficiency_Homo sapiens_hsa053400.61457138
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61303748
81Graft-versus-host disease_Homo sapiens_hsa053320.60639400
82Sulfur metabolism_Homo sapiens_hsa009200.60064564
83Allograft rejection_Homo sapiens_hsa053300.58736566
84Steroid biosynthesis_Homo sapiens_hsa001000.58379708
85Hippo signaling pathway_Homo sapiens_hsa043900.56988141
86Serotonergic synapse_Homo sapiens_hsa047260.56321982
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55763634
88Chemical carcinogenesis_Homo sapiens_hsa052040.55539201
89Glutathione metabolism_Homo sapiens_hsa004800.55447269
90Phagosome_Homo sapiens_hsa041450.54931022
91Basal cell carcinoma_Homo sapiens_hsa052170.53798226
92Alcoholism_Homo sapiens_hsa050340.53209627
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52521516
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51216112
95One carbon pool by folate_Homo sapiens_hsa006700.49224736
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47711586
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46709324
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46693326
99Herpes simplex infection_Homo sapiens_hsa051680.46492082
100Glutamatergic synapse_Homo sapiens_hsa047240.45885953
101Arachidonic acid metabolism_Homo sapiens_hsa005900.45838731
102Systemic lupus erythematosus_Homo sapiens_hsa053220.45716697
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.45350344
104Antigen processing and presentation_Homo sapiens_hsa046120.45349181
105Shigellosis_Homo sapiens_hsa051310.44046713
106Fat digestion and absorption_Homo sapiens_hsa049750.43433804
107HTLV-I infection_Homo sapiens_hsa051660.43111886
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42784315
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42333012
110Type I diabetes mellitus_Homo sapiens_hsa049400.42287330
111Synaptic vesicle cycle_Homo sapiens_hsa047210.42181477
112Viral carcinogenesis_Homo sapiens_hsa052030.41119695
113Morphine addiction_Homo sapiens_hsa050320.40704592
114Asthma_Homo sapiens_hsa053100.40211822
115TGF-beta signaling pathway_Homo sapiens_hsa043500.39852827
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39426689
117Cardiac muscle contraction_Homo sapiens_hsa042600.39010850
118Linoleic acid metabolism_Homo sapiens_hsa005910.38861440
119Tight junction_Homo sapiens_hsa045300.37181727
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.37119880
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34950763
122Wnt signaling pathway_Homo sapiens_hsa043100.34682319
123Sulfur relay system_Homo sapiens_hsa041220.34652600
124Carbon metabolism_Homo sapiens_hsa012000.33591462
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33481613
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32462930
127Tyrosine metabolism_Homo sapiens_hsa003500.31652679
128Colorectal cancer_Homo sapiens_hsa052100.30192215
129Circadian entrainment_Homo sapiens_hsa047130.29229961
130Olfactory transduction_Homo sapiens_hsa047400.29223832
131Renal cell carcinoma_Homo sapiens_hsa052110.28404668
132Biosynthesis of amino acids_Homo sapiens_hsa012300.28212788
133Arginine and proline metabolism_Homo sapiens_hsa003300.27374574
134GABAergic synapse_Homo sapiens_hsa047270.25955951
135MicroRNAs in cancer_Homo sapiens_hsa052060.24804983
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.24147995
137Pathways in cancer_Homo sapiens_hsa052000.23874213
138Taste transduction_Homo sapiens_hsa047420.23814517
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21483832
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21057008
141Hematopoietic cell lineage_Homo sapiens_hsa046400.20460329
142Metabolic pathways_Homo sapiens_hsa011000.19751303
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19215079
144Mineral absorption_Homo sapiens_hsa049780.17775048
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16234577

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