MBLAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.04945783
2ribosomal small subunit assembly (GO:0000028)6.46663498
3positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.06475478
4viral transcription (GO:0019083)5.90883355
5translational termination (GO:0006415)5.67656780
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.41552059
7cotranslational protein targeting to membrane (GO:0006613)5.29392409
8protein targeting to ER (GO:0045047)5.25679317
9translational elongation (GO:0006414)5.19238260
10ribosomal small subunit biogenesis (GO:0042274)5.14940995
11protein localization to endoplasmic reticulum (GO:0070972)5.00877970
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.98891256
13GDP-mannose metabolic process (GO:0019673)4.84242855
14substrate-independent telencephalic tangential migration (GO:0021826)4.78497364
15substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.78497364
16positive regulation of mitochondrial fission (GO:0090141)4.61161912
17viral life cycle (GO:0019058)4.57350866
18telomere maintenance via semi-conservative replication (GO:0032201)4.46797320
19cellular protein complex disassembly (GO:0043624)4.44068946
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.42867230
21DNA strand elongation involved in DNA replication (GO:0006271)4.38396866
22translational initiation (GO:0006413)4.31730960
23DNA strand elongation (GO:0022616)4.14186063
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.07620044
25mitochondrion morphogenesis (GO:0070584)3.95300864
26positive regulation of catecholamine secretion (GO:0033605)3.91779677
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.91416539
28protein complex disassembly (GO:0043241)3.90574450
29maturation of SSU-rRNA (GO:0030490)3.87730842
30behavioral response to nicotine (GO:0035095)3.84303812
31mitochondrial fusion (GO:0008053)3.79782811
32macromolecular complex disassembly (GO:0032984)3.73497683
33telomere maintenance via recombination (GO:0000722)3.69991185
34positive regulation of protein homooligomerization (GO:0032464)3.69268541
35ribosomal large subunit biogenesis (GO:0042273)3.59393898
36translation (GO:0006412)3.59094880
37regulation of protein heterodimerization activity (GO:0043497)3.56207628
38protein insertion into membrane (GO:0051205)3.53771328
39protein targeting to membrane (GO:0006612)3.52015623
40ribonucleoprotein complex biogenesis (GO:0022613)3.51418817
41response to acidic pH (GO:0010447)3.45100257
42mitochondrion degradation (GO:0000422)3.41563897
43cranial nerve morphogenesis (GO:0021602)3.39400999
44mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.36133708
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.33129010
46peroxisome fission (GO:0016559)3.30948744
47regulation of helicase activity (GO:0051095)3.29328293
48regulation of telomerase activity (GO:0051972)3.29238885
49DNA replication initiation (GO:0006270)3.26039376
50motile cilium assembly (GO:0044458)3.24871956
51mitotic recombination (GO:0006312)3.23326838
52platelet dense granule organization (GO:0060155)3.21811599
53formation of translation preinitiation complex (GO:0001731)3.20346193
54negative regulation of cAMP-mediated signaling (GO:0043951)3.18470311
55regulation of autophagic vacuole assembly (GO:2000785)3.18066876
56protein retention in ER lumen (GO:0006621)3.17341630
57telomere maintenance via telomere lengthening (GO:0010833)3.17094109
58metallo-sulfur cluster assembly (GO:0031163)3.16446937
59iron-sulfur cluster assembly (GO:0016226)3.16446937
60rRNA modification (GO:0000154)3.14455586
61mRNA catabolic process (GO:0006402)3.13661148
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.13484869
63regulation of mitochondrial fission (GO:0090140)3.11704740
64positive regulation of release of cytochrome c from mitochondria (GO:0090200)3.08476031
65response to parathyroid hormone (GO:0071107)3.08459348
66pseudouridine synthesis (GO:0001522)3.07487213
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.07375086
68ncRNA 3-end processing (GO:0043628)3.06841557
69cellular component biogenesis (GO:0044085)3.03601296
70rRNA processing (GO:0006364)3.03441625
71endosome to pigment granule transport (GO:0043485)3.03085819
72endosome to melanosome transport (GO:0035646)3.03085819
73heme biosynthetic process (GO:0006783)3.02985061
74viral genome replication (GO:0019079)3.02277908
75negative regulation of RNA splicing (GO:0033119)2.99929723
76purine-containing compound salvage (GO:0043101)2.98689242
77heterochromatin organization (GO:0070828)2.97814616
782-deoxyribonucleotide biosynthetic process (GO:0009265)2.97750257
79deoxyribose phosphate biosynthetic process (GO:0046385)2.97750257
80chaperone-mediated protein transport (GO:0072321)2.97634884
81positive regulation of TOR signaling (GO:0032008)2.96093518
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.94884044
83pyrimidine nucleotide catabolic process (GO:0006244)2.94737599
84DNA unwinding involved in DNA replication (GO:0006268)2.94560758
85signal peptide processing (GO:0006465)2.94539430
86misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.94350874
87regulation of dopamine secretion (GO:0014059)2.94338007
88RNA catabolic process (GO:0006401)2.94313318
89cellular extravasation (GO:0045123)2.94281136
90response to misfolded protein (GO:0051788)2.93959182
91respiratory chain complex IV assembly (GO:0008535)2.93390224
92pentose-phosphate shunt (GO:0006098)2.93279003
93sulfur amino acid catabolic process (GO:0000098)2.92836219
94rRNA metabolic process (GO:0016072)2.91959342
95pteridine-containing compound biosynthetic process (GO:0042559)2.91796326
96ribosome biogenesis (GO:0042254)2.91298338
97maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89563879
98kidney mesenchyme development (GO:0072074)2.89093494
99response to interferon-beta (GO:0035456)2.88193649
100regulation of apoptotic process involved in morphogenesis (GO:1902337)2.88138477
101tongue development (GO:0043586)2.88097240
102rRNA transcription (GO:0009303)2.87451984
103negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87085143
104sensory perception of taste (GO:0050909)2.86912596
105Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86796994
106negative regulation of erythrocyte differentiation (GO:0045647)2.86701934
107cell-cell junction maintenance (GO:0045217)2.85189652
108negative regulation of macroautophagy (GO:0016242)2.84633425
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83268766
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83268766
111apoptotic process involved in morphogenesis (GO:0060561)2.82867171
112folic acid metabolic process (GO:0046655)2.81810086
113UV protection (GO:0009650)2.80456174
114rRNA methylation (GO:0031167)2.79897869
115spliceosomal snRNP assembly (GO:0000387)2.78949502
116nucleobase-containing small molecule interconversion (GO:0015949)2.78902145
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78242771
118negative regulation of phagocytosis (GO:0050765)2.77529428
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77228648
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76511646
121pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76358640
122mRNA cleavage (GO:0006379)2.75027776
123UTP biosynthetic process (GO:0006228)2.74586394
124viral mRNA export from host cell nucleus (GO:0046784)2.74457337
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74315255
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73227206
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.73227206
128NADH dehydrogenase complex assembly (GO:0010257)2.73227206
129peptidyl-histidine modification (GO:0018202)2.72851730
130GTP biosynthetic process (GO:0006183)2.70768978
131proteasome assembly (GO:0043248)2.70571667
132regulation of synaptic transmission, dopaminergic (GO:0032225)2.69666622
133pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69465281
134apoptotic process involved in development (GO:1902742)2.69159226
135pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.68931389
136response to muscle activity (GO:0014850)2.68860858
137negative regulation of DNA-templated transcription, elongation (GO:0032785)2.68495139
138negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.68036254
139mitochondrial respiratory chain complex assembly (GO:0033108)2.67508639
140antigen processing and presentation via MHC class Ib (GO:0002475)2.67316416
141negative regulation of ligase activity (GO:0051352)2.66412624
142negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.66412624
143positive regulation of histone deacetylation (GO:0031065)2.66300863
144negative regulation of telomere maintenance (GO:0032205)2.66134896
145heme metabolic process (GO:0042168)2.66111203
146NADPH regeneration (GO:0006740)2.65948541
147negative regulation of telomerase activity (GO:0051974)2.65119833
148positive regulation of mitochondrion organization (GO:0010822)2.64379226
149metanephric mesenchyme development (GO:0072075)2.62896103
150coenzyme A biosynthetic process (GO:0015937)2.62539077
151histone mRNA metabolic process (GO:0008334)2.59948969
152negative regulation of microtubule polymerization (GO:0031115)2.59858212
153locomotory exploration behavior (GO:0035641)2.59654235
154establishment of integrated proviral latency (GO:0075713)2.59300530
155negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.59094184
156polyketide metabolic process (GO:0030638)2.58311324
157doxorubicin metabolic process (GO:0044598)2.58311324
158daunorubicin metabolic process (GO:0044597)2.58311324
159positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.58300357
160regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.57670417
161positive regulation of protein kinase C signaling (GO:0090037)2.56917989
162nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56443299
163muscle cell fate commitment (GO:0042693)2.56304451
164regulation of mitochondrial translation (GO:0070129)2.55662344
165antigen processing and presentation of endogenous antigen (GO:0019883)2.55549259
166determination of adult lifespan (GO:0008340)2.54822361
167tooth mineralization (GO:0034505)2.54394187
168pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.53038227
169negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.52814368
170regulation of vacuole organization (GO:0044088)2.52165451
171regulation of cellular respiration (GO:0043457)2.51252138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.01960057
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.39039035
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.77861431
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.70870628
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.43296075
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.16026052
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04921552
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02599137
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.99879256
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88906169
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80028533
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.74494532
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72380891
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.72052461
15TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.67876870
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.63295852
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58808348
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.56695764
19LXR_22292898_ChIP-Seq_THP-1_Human2.49051221
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.47373548
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34969093
22TET1_21451524_ChIP-Seq_MESCs_Mouse2.34076932
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25286169
24VDR_23849224_ChIP-Seq_CD4+_Human2.24722489
25XRN2_22483619_ChIP-Seq_HELA_Human2.24372653
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16199754
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12923327
28P68_20966046_ChIP-Seq_HELA_Human2.11839897
29SCL_19346495_ChIP-Seq_HPC-7_Human2.06991809
30* ERG_20887958_ChIP-Seq_HPC-7_Mouse2.06917223
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05585855
32DCP1A_22483619_ChIP-Seq_HELA_Human2.02883545
33VDR_21846776_ChIP-Seq_THP-1_Human2.02550040
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02466915
35E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01798417
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00337437
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.97738388
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.97453827
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.96078913
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95863523
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93656011
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93340626
43FOXP3_21729870_ChIP-Seq_TREG_Human1.90378269
44CTCF_27219007_Chip-Seq_Bcells_Human1.87271884
45GABP_19822575_ChIP-Seq_HepG2_Human1.87222350
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85014602
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84794728
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.82738495
49MYC_22102868_ChIP-Seq_BL_Human1.82649024
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.81265358
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81093472
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81009927
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79812486
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.77655664
55CIITA_25753668_ChIP-Seq_RAJI_Human1.76307872
56TTF2_22483619_ChIP-Seq_HELA_Human1.75382487
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75174732
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75156873
59RACK7_27058665_Chip-Seq_MCF-7_Human1.74008824
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.73276845
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72656077
62BCL6_27268052_Chip-Seq_Bcells_Human1.71511240
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71443829
64MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.68254456
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67648092
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65363852
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65333162
68CTCF_21964334_Chip-Seq_Bcells_Human1.64864537
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63003842
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62955036
71SPI1_23547873_ChIP-Seq_NB4_Human1.61466762
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60127514
73* KDM2B_26808549_Chip-Seq_DND41_Human1.59314818
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.59263982
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59083465
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58472416
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.55785754
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.55752169
79FOXP1_21924763_ChIP-Seq_HESCs_Human1.53178590
80MAF_26560356_Chip-Seq_TH2_Human1.52969246
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51304958
82SMC4_20622854_ChIP-Seq_HELA_Human1.48085568
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47910146
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46311479
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46120870
86GATA1_22025678_ChIP-Seq_K562_Human1.45718816
87KDM2B_26808549_Chip-Seq_K562_Human1.44707556
88PHF8_20622854_ChIP-Seq_HELA_Human1.44367024
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42318160
90BCOR_27268052_Chip-Seq_Bcells_Human1.42205640
91E2F1_20622854_ChIP-Seq_HELA_Human1.41617618
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40979153
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38860977
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37966200
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37959385
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37134447
97ZNF263_19887448_ChIP-Seq_K562_Human1.35999813
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.35690467
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35519181
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35267484
101ELK1_19687146_ChIP-ChIP_HELA_Human1.34946938
102VDR_24763502_ChIP-Seq_THP-1_Human1.33905095
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33597494
104CTCF_21964334_ChIP-Seq_BJAB-B_Human1.30753240
105TP53_22127205_ChIP-Seq_IMR90_Human1.30011500
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29927265
107CTCF_20526341_ChIP-Seq_ESCs_Human1.29362596
108E2F1_21310950_ChIP-Seq_MCF-7_Human1.29358878
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29073014
110CREB1_26743006_Chip-Seq_LNCaP_Human1.28821441
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27920169
112RARA_24833708_ChIP-Seq_LIVER_Mouse1.27827710
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24190287
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23322994
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23052938
116SA1_27219007_Chip-Seq_Bcells_Human1.22133310
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21683210
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19588549
119RUNX1_22412390_ChIP-Seq_EML_Mouse1.19308278
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.18591225
121KDM5A_27292631_Chip-Seq_BREAST_Human1.18312772
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18253114
123SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18179289
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17098969
125CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16959574
126CTCF_26484167_Chip-Seq_Bcells_Mouse1.16951847
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15750533
128ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15541214
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15024606
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14852394
131MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13900401
132STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12769929
133PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11998535
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11489631
135RARB_24833708_ChIP-Seq_LIVER_Mouse1.10402701
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09435617
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09268060
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08626063
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08232297
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08153630
141TP53_20018659_ChIP-ChIP_R1E_Mouse1.07774593
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07324025
143GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06578879
144SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06565921
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05726237
146IRF8_21731497_ChIP-ChIP_J774_Mouse1.05444254
147PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04512220
148SPI1_20517297_ChIP-Seq_HL60_Human1.02617053
149MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01915638
150POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01682585
151RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01465756
152TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00090156
153EZH2_22144423_ChIP-Seq_EOC_Human0.99986797
154* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99816453
155STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99526103
156EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99197065
157MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98848824
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98553415
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97923933
160TFEB_21752829_ChIP-Seq_HELA_Human0.97879883
161UTX_26944678_Chip-Seq_JUKART_Human0.97727251
162DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97136923
163FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96462535
164* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96333137
165SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95128921
166EGR1_19374776_ChIP-ChIP_THP-1_Human0.94915494
167CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94897307
168MYB_26560356_Chip-Seq_TH2_Human0.94641264
169CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92512935
170BP1_19119308_ChIP-ChIP_Hs578T_Human0.92477824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.86854203
2MP0005423_abnormal_somatic_nervous3.76139455
3MP0002396_abnormal_hematopoietic_system3.56975383
4MP0001188_hyperpigmentation3.47655984
5MP0009840_abnormal_foam_cell3.46489607
6MP0003123_paternal_imprinting3.31317095
7MP0001529_abnormal_vocalization3.00972289
8MP0001849_ear_inflammation2.80723478
9MP0009785_altered_susceptibility_to2.76645882
10MP0005075_abnormal_melanosome_morpholog2.60770722
11MP0002822_catalepsy2.60322690
12MP0000372_irregular_coat_pigmentation2.57982630
13MP0001835_abnormal_antigen_presentation2.51462699
14MP0000490_abnormal_crypts_of2.48827791
15MP0004147_increased_porphyrin_level2.48543242
16MP0003315_abnormal_perineum_morphology2.39470744
17MP0009333_abnormal_splenocyte_physiolog2.35791723
18MP0000685_abnormal_immune_system2.35122538
19MP0005394_taste/olfaction_phenotype2.34729611
20MP0005499_abnormal_olfactory_system2.34729611
21MP0005397_hematopoietic_system_phenotyp2.32446604
22MP0001545_abnormal_hematopoietic_system2.32446604
23MP0002095_abnormal_skin_pigmentation2.32353099
24MP0010030_abnormal_orbit_morphology2.32120007
25MP0005174_abnormal_tail_pigmentation2.29827011
26MP0003122_maternal_imprinting2.24965269
27MP0008789_abnormal_olfactory_epithelium2.19544061
28MP0003656_abnormal_erythrocyte_physiolo2.16848765
29MP0005670_abnormal_white_adipose2.14871294
30MP0006054_spinal_hemorrhage2.09576954
31MP0002148_abnormal_hypersensitivity_rea2.06998606
32MP0005451_abnormal_body_composition2.04062559
33MP0008007_abnormal_cellular_replicative2.01346636
34MP0005671_abnormal_response_to1.99666000
35MP0010094_abnormal_chromosome_stability1.96776879
36MP0003787_abnormal_imprinting1.96542150
37MP0003111_abnormal_nucleus_morphology1.95908217
38MP0001905_abnormal_dopamine_level1.95450334
39MP0009379_abnormal_foot_pigmentation1.93900246
40MP0004957_abnormal_blastocyst_morpholog1.93769080
41MP0005025_abnormal_response_to1.92931614
42MP0003436_decreased_susceptibility_to1.89492515
43MP0001968_abnormal_touch/_nociception1.88488156
44MP0004808_abnormal_hematopoietic_stem1.81703383
45MP0003806_abnormal_nucleotide_metabolis1.77896186
46MP0002398_abnormal_bone_marrow1.77049628
47MP0003077_abnormal_cell_cycle1.75741433
48MP0000343_altered_response_to1.73456444
49MP0000049_abnormal_middle_ear1.72523762
50MP0002419_abnormal_innate_immunity1.71103428
51MP0006036_abnormal_mitochondrial_physio1.68922431
52MP0004233_abnormal_muscle_weight1.67420566
53MP0000015_abnormal_ear_pigmentation1.66351127
54MP0009278_abnormal_bone_marrow1.66259467
55MP0005000_abnormal_immune_tolerance1.65614635
56MP0005464_abnormal_platelet_physiology1.64769314
57MP0002837_dystrophic_cardiac_calcinosis1.64376935
58MP0005083_abnormal_biliary_tract1.62990157
59MP0001348_abnormal_lacrimal_gland1.61683443
60MP0003763_abnormal_thymus_physiology1.61613025
61MP0008057_abnormal_DNA_replication1.60197795
62MP0001502_abnormal_circadian_rhythm1.59299216
63MP0001919_abnormal_reproductive_system1.58909921
64MP0004185_abnormal_adipocyte_glucose1.58401965
65MP0001800_abnormal_humoral_immune1.58083954
66MP0000689_abnormal_spleen_morphology1.57560895
67MP0000465_gastrointestinal_hemorrhage1.57143999
68MP0006276_abnormal_autonomic_nervous1.56147746
69MP0002420_abnormal_adaptive_immunity1.55601519
70MP0001853_heart_inflammation1.55172143
71MP0001819_abnormal_immune_cell1.52482778
72MP0002452_abnormal_antigen_presenting1.52100721
73MP0002722_abnormal_immune_system1.51943105
74MP0004859_abnormal_synaptic_plasticity1.51264559
75MP0000537_abnormal_urethra_morphology1.49356623
76MP0002723_abnormal_immune_serum1.48797958
77MP0000716_abnormal_immune_system1.48321483
78MP0002429_abnormal_blood_cell1.47879698
79MP0001661_extended_life_span1.44397155
80MP0003186_abnormal_redox_activity1.43795210
81MP0008058_abnormal_DNA_repair1.39810385
82MP0000003_abnormal_adipose_tissue1.39290176
83MP0000747_muscle_weakness1.38933860
84MP0005058_abnormal_lysosome_morphology1.38275008
85MP0003191_abnormal_cellular_cholesterol1.35136136
86MP0003866_abnormal_defecation1.31801765
87MP0004130_abnormal_muscle_cell1.31746168
88MP0003724_increased_susceptibility_to1.30501404
89MP0001270_distended_abdomen1.28793403
90MP0008469_abnormal_protein_level1.27799171
91MP0001845_abnormal_inflammatory_respons1.27158726
92MP0005389_reproductive_system_phenotype1.25232784
93MP0000703_abnormal_thymus_morphology1.24736943
94MP0005409_darkened_coat_color1.24650969
95MP0003172_abnormal_lysosome_physiology1.22716942
96MP0008932_abnormal_embryonic_tissue1.20041074
97MP0003136_yellow_coat_color1.19152597
98MP0010155_abnormal_intestine_physiology1.18078438
99MP0000358_abnormal_cell_content/1.17604456
100MP0000750_abnormal_muscle_regeneration1.17513901
101MP0002249_abnormal_larynx_morphology1.16701053
102MP0001756_abnormal_urination1.16106264
103MP0002735_abnormal_chemical_nociception1.15697579
104MP0000538_abnormal_urinary_bladder1.15495822
105MP0005666_abnormal_adipose_tissue1.14803246
106MP0001984_abnormal_olfaction1.14393298
107MP0003183_abnormal_peptide_metabolism1.14222203
108MP0002405_respiratory_system_inflammati1.12889398
109MP0002019_abnormal_tumor_incidence1.12516850
110MP0002736_abnormal_nociception_after1.12449001
111MP0003635_abnormal_synaptic_transmissio1.11012001
112MP0005375_adipose_tissue_phenotype1.10866143
113MP0003879_abnormal_hair_cell1.10679132
114MP0000759_abnormal_skeletal_muscle1.05340905
115MP0000749_muscle_degeneration1.05068478
116MP0000313_abnormal_cell_death1.04748741
117MP0009764_decreased_sensitivity_to1.03833502
118MP0002166_altered_tumor_susceptibility1.03755977
119MP0003942_abnormal_urinary_system1.01950004
120MP0001986_abnormal_taste_sensitivity1.01523980
121MP0003121_genomic_imprinting1.00948088
122MP0001663_abnormal_digestive_system0.99438885
123MP0006035_abnormal_mitochondrial_morpho0.98641138
124MP0001873_stomach_inflammation0.98193780
125MP0005330_cardiomyopathy0.98112477
126MP0005332_abnormal_amino_acid0.97210569
127MP0005220_abnormal_exocrine_pancreas0.96427491
128MP0005636_abnormal_mineral_homeostasis0.90709000
129MP0002163_abnormal_gland_morphology0.89567356
130MP0003880_abnormal_central_pattern0.88147110
131MP0001970_abnormal_pain_threshold0.87749557
132MP0000955_abnormal_spinal_cord0.87735676
133MP0001790_abnormal_immune_system0.86684598
134MP0005387_immune_system_phenotype0.86684598
135MP0000678_abnormal_parathyroid_gland0.85932365
136MP0005410_abnormal_fertilization0.85212606
137MP0002063_abnormal_learning/memory/cond0.82703154
138MP0008874_decreased_physiological_sensi0.82434096
139MP0003705_abnormal_hypodermis_morpholog0.81714422
140MP0001764_abnormal_homeostasis0.81331104
141MP0004043_abnormal_pH_regulation0.81058717
142MP0003786_premature_aging0.80657869
143MP0002653_abnormal_ependyma_morphology0.80643476
144MP0008875_abnormal_xenobiotic_pharmacok0.79968270
145MP0008004_abnormal_stomach_pH0.79813498
146MP0000733_abnormal_muscle_development0.78411020
147MP0002572_abnormal_emotion/affect_behav0.78172138
148MP0002272_abnormal_nervous_system0.77606223
149MP0002557_abnormal_social/conspecific_i0.77579803
150MP0000858_altered_metastatic_potential0.76352307
151MP0000350_abnormal_cell_proliferation0.76350419
152MP0003221_abnormal_cardiomyocyte_apopto0.76194240
153MP0002160_abnormal_reproductive_system0.75225349
154MP0005310_abnormal_salivary_gland0.75081345
155MP0003385_abnormal_body_wall0.74952908
156MP0002638_abnormal_pupillary_reflex0.74764445
157MP0006292_abnormal_olfactory_placode0.74293759
158MP0010386_abnormal_urinary_bladder0.74107556
159MP0001186_pigmentation_phenotype0.73692388
160MP0002752_abnormal_somatic_nervous0.73298548
161MP0002938_white_spotting0.72524790
162MP0005319_abnormal_enzyme/_coenzyme0.71569633
163MP0002734_abnormal_mechanical_nocicepti0.70997218
164MP0000681_abnormal_thyroid_gland0.70750062
165MP0000778_abnormal_nervous_system0.69933747
166MP0004510_myositis0.69884674
167MP0005501_abnormal_skin_physiology0.67999472
168MP0001533_abnormal_skeleton_physiology0.67500729
169MP0004858_abnormal_nervous_system0.66241185
170MP0005360_urolithiasis0.65609932
171MP0002152_abnormal_brain_morphology0.65181358
172MP0008873_increased_physiological_sensi0.64233277
173MP0002075_abnormal_coat/hair_pigmentati0.63733041
174MP0000598_abnormal_liver_morphology0.63613950
175MP0002080_prenatal_lethality0.62369404
176MP0000751_myopathy0.62138109
177MP0002877_abnormal_melanocyte_morpholog0.61876463
178MP0005164_abnormal_response_to0.61711764
179MP0004811_abnormal_neuron_physiology0.61673017
180MP0009643_abnormal_urine_homeostasis0.60209896

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.80433477
2Abnormal number of erythroid precursors (HP:0012131)5.79280647
3Reticulocytopenia (HP:0001896)4.38802415
4Aplastic anemia (HP:0001915)4.30494068
5Petechiae (HP:0000967)4.29076872
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.27853103
7Reduced antithrombin III activity (HP:0001976)4.13783474
8Thrombocytosis (HP:0001894)4.01141649
9Type I transferrin isoform profile (HP:0003642)3.82264769
10Testicular atrophy (HP:0000029)3.70449460
11Hepatocellular necrosis (HP:0001404)3.55232770
12Rib fusion (HP:0000902)3.51225976
13Hyperthyroidism (HP:0000836)3.47260611
14Pallor (HP:0000980)3.40900030
15Abnormal protein glycosylation (HP:0012346)3.37701501
16Abnormal glycosylation (HP:0012345)3.37701501
17Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.37701501
18Abnormal protein N-linked glycosylation (HP:0012347)3.37701501
19Hepatic necrosis (HP:0002605)3.36556735
20Chronic otitis media (HP:0000389)3.35518049
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34187991
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34187991
23Elevated erythrocyte sedimentation rate (HP:0003565)3.21765418
24Severe visual impairment (HP:0001141)3.16250840
25Thin bony cortex (HP:0002753)3.13708465
26Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11746620
27Increased hepatocellular lipid droplets (HP:0006565)3.05904960
28Impaired platelet aggregation (HP:0003540)3.02606361
29Abnormal platelet function (HP:0011869)3.02606361
30Annular pancreas (HP:0001734)2.97328732
31Absent thumb (HP:0009777)2.95490455
32Ependymoma (HP:0002888)2.94264120
33Oral leukoplakia (HP:0002745)2.87084161
34Increased serum lactate (HP:0002151)2.86589759
35Lipid accumulation in hepatocytes (HP:0006561)2.85828165
36Macrocytic anemia (HP:0001972)2.84153195
37Squamous cell carcinoma (HP:0002860)2.84096266
38Recurrent abscess formation (HP:0002722)2.79909759
39Poor head control (HP:0002421)2.78191888
40Mitochondrial inheritance (HP:0001427)2.75283193
41Microretrognathia (HP:0000308)2.74334231
42Microvesicular hepatic steatosis (HP:0001414)2.73149370
43Adrenal hypoplasia (HP:0000835)2.69686131
44Increased CSF lactate (HP:0002490)2.69644710
45Hypothermia (HP:0002045)2.69458255
46Myokymia (HP:0002411)2.67911291
47Prolonged bleeding time (HP:0003010)2.66993277
48Abnormality of the columella (HP:0009929)2.65844246
49Congenital malformation of the right heart (HP:0011723)2.65782782
50Double outlet right ventricle (HP:0001719)2.65782782
51Increased intramyocellular lipid droplets (HP:0012240)2.64139912
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62383120
53Recurrent bacterial skin infections (HP:0005406)2.56462203
54Increased muscle lipid content (HP:0009058)2.46538814
55Abnormality of the nasal mucosa (HP:0000433)2.45110033
56Thoracic kyphosis (HP:0002942)2.40234464
57Progressive neurologic deterioration (HP:0002344)2.39267498
58Ragged-red muscle fibers (HP:0003200)2.38217852
59Lactic acidosis (HP:0003128)2.35883041
60Abnormal mitochondria in muscle tissue (HP:0008316)2.35023569
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34435288
62Abnormal rod and cone electroretinograms (HP:0008323)2.31286408
63High anterior hairline (HP:0009890)2.28179280
64Pancytopenia (HP:0001876)2.27744560
65Exertional dyspnea (HP:0002875)2.27558124
66Muscle stiffness (HP:0003552)2.26989255
67Fetal akinesia sequence (HP:0001989)2.26860795
68Neonatal hypoglycemia (HP:0001998)2.26285129
69Panhypogammaglobulinemia (HP:0003139)2.25578961
70Pulmonary fibrosis (HP:0002206)2.25084285
71Epistaxis (HP:0000421)2.23125131
72Neoplasm of the adrenal cortex (HP:0100641)2.22888174
73Vacuolated lymphocytes (HP:0001922)2.22623575
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20637921
75Rough bone trabeculation (HP:0100670)2.19654176
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.19165904
77Birth length less than 3rd percentile (HP:0003561)2.18805830
78Abnormality of DNA repair (HP:0003254)2.18646847
79Pendular nystagmus (HP:0012043)2.17796666
80IgM deficiency (HP:0002850)2.17053967
81Acute necrotizing encephalopathy (HP:0006965)2.15621390
82Scapular winging (HP:0003691)2.15497319
83Nasal polyposis (HP:0100582)2.15090916
84Delayed epiphyseal ossification (HP:0002663)2.13451489
8511 pairs of ribs (HP:0000878)2.13133199
86Abnormality of the intrinsic pathway (HP:0010989)2.12938647
87Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12127940
88Abnormality of T cell physiology (HP:0011840)2.11511717
89Prolonged neonatal jaundice (HP:0006579)2.10953567
90Broad distal phalanx of finger (HP:0009836)2.10952689
91Bulbar palsy (HP:0001283)2.10214822
92Poikiloderma (HP:0001029)2.10104256
93Myotonia (HP:0002486)2.09536505
94Abnormality of homocysteine metabolism (HP:0010919)2.07682142
95Homocystinuria (HP:0002156)2.07682142
96Periauricular skin pits (HP:0100277)2.07497157
97Preauricular pit (HP:0004467)2.07497157
98Renal Fanconi syndrome (HP:0001994)2.06645114
99Recurrent viral infections (HP:0004429)2.04680564
100Selective tooth agenesis (HP:0001592)2.04320246
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03733204
102Facial hemangioma (HP:0000329)2.02690634
103Widely patent fontanelles and sutures (HP:0004492)2.00821086
104Albinism (HP:0001022)1.99879903
105Abnormality of reticulocytes (HP:0004312)1.99839677
106Abnormality of the astrocytes (HP:0100707)1.99486405
107Astrocytoma (HP:0009592)1.99486405
108Increased serum ferritin (HP:0003281)1.98826007
109Abnormality of the thoracic spine (HP:0100711)1.97708477
110Neutropenia (HP:0001875)1.97289945
111Mesangial abnormality (HP:0001966)1.96423052
112Constricted visual fields (HP:0001133)1.96392304
113Large eyes (HP:0001090)1.96128673
114Myositis (HP:0100614)1.94545133
115Akinesia (HP:0002304)1.94031145
116Vaginal fistula (HP:0004320)1.92701177
117Cutaneous melanoma (HP:0012056)1.92586166
118Exercise intolerance (HP:0003546)1.91808020
119Retinal atrophy (HP:0001105)1.91541985
120Cerebral hypomyelination (HP:0006808)1.90352868
121Myopathic facies (HP:0002058)1.90228976
122Muscle fiber atrophy (HP:0100295)1.89859641
123Fused cervical vertebrae (HP:0002949)1.89578483
124Meningitis (HP:0001287)1.88854836
125Vertebral compression fractures (HP:0002953)1.87392014
126Turricephaly (HP:0000262)1.87357682
127Recurrent skin infections (HP:0001581)1.85713870
128Premature graying of hair (HP:0002216)1.84982007
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.83932665
130Abnormality of the shoulder girdle musculature (HP:0001435)1.83870900
131Amblyopia (HP:0000646)1.82707861
132Hypokinesia (HP:0002375)1.81300249
133Lymphoma (HP:0002665)1.80873207
134Rectovaginal fistula (HP:0000143)1.80604235
135Rectal fistula (HP:0100590)1.80604235
136Generalized aminoaciduria (HP:0002909)1.80542987
137B lymphocytopenia (HP:0010976)1.80290410
138Abnormality of B cell number (HP:0010975)1.80290410
139Broad face (HP:0000283)1.79902888
140Abnormal trabecular bone morphology (HP:0100671)1.79399189
141Chronic sinusitis (HP:0011109)1.77789214
142Bony spicule pigmentary retinopathy (HP:0007737)1.77571803
143Microcytic anemia (HP:0001935)1.76385888
144Acute encephalopathy (HP:0006846)1.75991321
145Spinal rigidity (HP:0003306)1.75943004
146Basal cell carcinoma (HP:0002671)1.75775903
147Optic nerve coloboma (HP:0000588)1.75516471
148Multiple enchondromatosis (HP:0005701)1.75029117
149Self-mutilation (HP:0000742)1.74618689
150Hypoproteinemia (HP:0003075)1.74322827
151Pancreatic fibrosis (HP:0100732)1.74305193
152Type II lissencephaly (HP:0007260)1.74187188
1533-Methylglutaconic aciduria (HP:0003535)1.73934895
154Abnormality of the prostate (HP:0008775)1.73502419
155Agnosia (HP:0010524)1.73357889
156Poor eye contact (HP:0000817)1.73130845
157Respiratory difficulties (HP:0002880)1.72945511
158Dysostosis multiplex (HP:0000943)1.72554719
159Aplasia of the musculature (HP:0100854)1.71614754
160Renal dysplasia (HP:0000110)1.70223131
161Myelodysplasia (HP:0002863)1.70155560
162Purpura (HP:0000979)1.69325680
163Type 2 muscle fiber atrophy (HP:0003554)1.68249663
164Depression (HP:0000716)1.68220345
165Abnormality of the costochondral junction (HP:0000919)1.68171813
166Sensory axonal neuropathy (HP:0003390)1.67286510
167Truncus arteriosus (HP:0001660)1.66598837
168Ulnar bowing (HP:0003031)1.66135048
169Intestinal fistula (HP:0100819)1.62989458
170Retinal dysplasia (HP:0007973)1.62982023
171Long palpebral fissure (HP:0000637)1.62621508
172Methylmalonic aciduria (HP:0012120)1.62094153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.33980457
2NME23.56089252
3SCYL23.27366678
4TRIB33.13916132
5PINK13.10859259
6TNIK2.74125397
7ICK2.69902492
8SMG12.63363963
9WEE12.62689833
10PIM22.61259279
11IRAK42.57054230
12BUB12.56094118
13KIT2.32689844
14BLK2.32051456
15TGFBR12.20886187
16PRKD32.15270692
17VRK12.14817582
18ERN12.08353405
19INSRR2.05588632
20CDK192.03094201
21TEC2.02656248
22FLT32.00362811
23DYRK31.96139290
24SIK11.88657538
25EIF2AK31.84576619
26PRPF4B1.83600872
27CAMKK21.75052547
28CDC71.73221193
29BTK1.72440343
30BRSK21.71326413
31EPHB21.70177654
32ZAK1.68852136
33VRK21.64729983
34MARK31.57053770
35BCKDK1.50861664
36ACVR1B1.47130327
37TESK21.45609011
38TAF11.43365533
39NEK21.42918958
40DAPK31.42409013
41MAP3K111.39171522
42KDR1.38629109
43TLK11.38563605
44MAP4K11.37872565
45TGFBR21.36356125
46CSNK1A1L1.28667711
47CSNK1G31.26365429
48EEF2K1.26289321
49MAPK151.24819521
50PASK1.23813094
51CDK81.20239522
52MAP2K71.18764648
53TYK21.15995302
54ZAP701.14392599
55MAP3K121.10885355
56EIF2AK11.10296264
57MARK21.09694223
58RPS6KA21.09165736
59CAMK1D1.09048438
60MAP3K101.08125358
61RPS6KA51.05127917
62TBK11.04553031
63DYRK1B1.03389961
64MATK1.01889134
65SYK1.01802933
66CAMKK11.01271043
67MAP3K61.01090090
68SRPK11.00637033
69LRRK21.00232211
70RPS6KA40.99073374
71CDK70.97318455
72MAPK120.97077897
73AURKA0.96062546
74PRKG20.92899166
75CSF1R0.88197288
76CSNK1G20.87433707
77TESK10.86268212
78MAP2K30.85733227
79CSNK1G10.85025259
80NEK90.84801346
81BRSK10.84002312
82DAPK10.82945922
83RAF10.81289903
84SIK20.80655216
85MAP2K60.79592471
86TAOK30.77884350
87IRAK20.77880710
88FES0.76927043
89CAMK10.76326887
90STK110.75794551
91AURKB0.75524480
92LYN0.74182267
93LATS20.74077565
94RPS6KC10.72984385
95RPS6KL10.72984385
96ATR0.71583302
97ARAF0.70942124
98PRKCI0.68432662
99PLK10.67013320
100ABL20.66301079
101OBSCN0.65859407
102NME10.65593875
103PRKD20.65275425
104RPS6KA60.63905512
105STK40.62007759
106GRK50.61921794
107HIPK20.61652286
108SGK2230.59718637
109SGK4940.59718637
110MAP3K80.59623883
111CAMK40.59008211
112PAK10.57975834
113MAPK40.57898541
114MINK10.57774918
115RPS6KB20.57763481
116PAK40.57559334
117BRAF0.57471270
118MAPKAPK30.55601218
119PIM10.53896412
120MOS0.53207534
121IRAK30.53111993
122MUSK0.52265743
123PKN20.52145395
124PLK40.51610242
125CDK140.49804650
126STK100.49758376
127PDPK10.49294517
128CDK40.48737793
129MTOR0.48589516
130AKT20.48553141
131ILK0.48146882
132MAP3K10.47900833
133CCNB10.46792519
134MKNK10.45623843
135NEK10.45135439
136WNK40.44513161
137CSNK2A10.43454660
138TAOK10.43350922
139TAOK20.43277811
140CHEK20.41452958
141PKN10.41324382
142PRKAA10.40644229
143CDK30.39932989
144DYRK20.39276090
145NLK0.37380610
146MYLK0.36398109
147CSNK1A10.36298798
148CSNK2A20.36095450
149EIF2AK20.35468291
150YES10.34341640
151MAPK110.33976435
152MAPKAPK20.33079326
153MELK0.32642160
154IRAK10.32576153
155CDK150.31735672
156CDK90.31529856
157CDK11A0.31343188
158PRKCQ0.30982146
159GRK10.30668184
160IKBKE0.30400643
161RIPK40.30354385

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.23491290
2DNA replication_Homo sapiens_hsa030304.84233152
3Mismatch repair_Homo sapiens_hsa034303.51800103
4Proteasome_Homo sapiens_hsa030503.08956798
5Base excision repair_Homo sapiens_hsa034102.75204083
6Protein export_Homo sapiens_hsa030602.74180860
7Sulfur relay system_Homo sapiens_hsa041222.69082199
8Pyrimidine metabolism_Homo sapiens_hsa002402.50696106
9RNA polymerase_Homo sapiens_hsa030202.34129538
10Spliceosome_Homo sapiens_hsa030402.30099778
11Homologous recombination_Homo sapiens_hsa034402.26050055
12N-Glycan biosynthesis_Homo sapiens_hsa005102.20997728
13Nucleotide excision repair_Homo sapiens_hsa034202.20271039
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00677995
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80447537
16Hedgehog signaling pathway_Homo sapiens_hsa043401.79869886
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75655618
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.75463399
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71269311
20Parkinsons disease_Homo sapiens_hsa050121.66814046
21Folate biosynthesis_Homo sapiens_hsa007901.65820861
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60917375
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57333945
24Basal cell carcinoma_Homo sapiens_hsa052171.54111576
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.53041573
26Oxidative phosphorylation_Homo sapiens_hsa001901.48822642
27Other glycan degradation_Homo sapiens_hsa005111.46602466
28Cell cycle_Homo sapiens_hsa041101.44477207
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42999814
30Pyruvate metabolism_Homo sapiens_hsa006201.41564295
31RNA transport_Homo sapiens_hsa030131.37937331
32Cardiac muscle contraction_Homo sapiens_hsa042601.34357436
33Huntingtons disease_Homo sapiens_hsa050161.33437544
34Purine metabolism_Homo sapiens_hsa002301.29186752
35Pentose phosphate pathway_Homo sapiens_hsa000301.27628438
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24549766
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23656440
38RNA degradation_Homo sapiens_hsa030181.21092555
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20595737
40Antigen processing and presentation_Homo sapiens_hsa046121.14383503
41Systemic lupus erythematosus_Homo sapiens_hsa053221.12582298
42Herpes simplex infection_Homo sapiens_hsa051681.10805790
43Basal transcription factors_Homo sapiens_hsa030221.07742911
44Thyroid cancer_Homo sapiens_hsa052161.05282993
45One carbon pool by folate_Homo sapiens_hsa006701.04323031
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97916872
47Nicotine addiction_Homo sapiens_hsa050330.97758832
48Selenocompound metabolism_Homo sapiens_hsa004500.96985199
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96612370
50Alzheimers disease_Homo sapiens_hsa050100.96040521
51Fanconi anemia pathway_Homo sapiens_hsa034600.93099540
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92077917
53Sphingolipid metabolism_Homo sapiens_hsa006000.91505314
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88046343
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87040225
56p53 signaling pathway_Homo sapiens_hsa041150.86841802
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86037729
58Renin-angiotensin system_Homo sapiens_hsa046140.83906205
59Primary immunodeficiency_Homo sapiens_hsa053400.81582445
60Hippo signaling pathway_Homo sapiens_hsa043900.80826483
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80172290
62Axon guidance_Homo sapiens_hsa043600.79868309
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79007422
64Cocaine addiction_Homo sapiens_hsa050300.77802361
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.77781946
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76846268
67Galactose metabolism_Homo sapiens_hsa000520.75954896
68Leishmaniasis_Homo sapiens_hsa051400.73810209
69Legionellosis_Homo sapiens_hsa051340.72917685
70Synaptic vesicle cycle_Homo sapiens_hsa047210.72673432
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72545344
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.70738758
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70570445
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69770551
75AMPK signaling pathway_Homo sapiens_hsa041520.69370525
76Epstein-Barr virus infection_Homo sapiens_hsa051690.68375730
77Glutathione metabolism_Homo sapiens_hsa004800.68292184
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67788675
79Melanogenesis_Homo sapiens_hsa049160.67257595
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65460095
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64480643
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63978079
83Olfactory transduction_Homo sapiens_hsa047400.63760726
84Non-homologous end-joining_Homo sapiens_hsa034500.63260851
85Shigellosis_Homo sapiens_hsa051310.61668708
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60192856
87Pertussis_Homo sapiens_hsa051330.59914126
88Regulation of autophagy_Homo sapiens_hsa041400.59442189
89Fructose and mannose metabolism_Homo sapiens_hsa000510.57502444
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57110594
91Gap junction_Homo sapiens_hsa045400.57017860
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.56823907
93Oxytocin signaling pathway_Homo sapiens_hsa049210.56178848
94Melanoma_Homo sapiens_hsa052180.55284327
95Apoptosis_Homo sapiens_hsa042100.54414956
96Metabolic pathways_Homo sapiens_hsa011000.54042744
97Bladder cancer_Homo sapiens_hsa052190.53517045
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53120470
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.53034389
100Notch signaling pathway_Homo sapiens_hsa043300.52483122
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.51316623
102Malaria_Homo sapiens_hsa051440.51189049
103Lysosome_Homo sapiens_hsa041420.51180032
104Morphine addiction_Homo sapiens_hsa050320.50970686
105Alcoholism_Homo sapiens_hsa050340.50728290
106Glucagon signaling pathway_Homo sapiens_hsa049220.50521792
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.50323024
108Hematopoietic cell lineage_Homo sapiens_hsa046400.48812731
109Biosynthesis of amino acids_Homo sapiens_hsa012300.48580607
110Phenylalanine metabolism_Homo sapiens_hsa003600.48420933
111Carbon metabolism_Homo sapiens_hsa012000.48301675
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46401424
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46168343
114Endometrial cancer_Homo sapiens_hsa052130.46066889
115VEGF signaling pathway_Homo sapiens_hsa043700.45330351
116mTOR signaling pathway_Homo sapiens_hsa041500.43735770
117Caffeine metabolism_Homo sapiens_hsa002320.43708599
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.42858584
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41814461
120Viral carcinogenesis_Homo sapiens_hsa052030.41638005
121Sulfur metabolism_Homo sapiens_hsa009200.41212859
122Arginine and proline metabolism_Homo sapiens_hsa003300.41108792
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40348872
124Peroxisome_Homo sapiens_hsa041460.40070594
125Acute myeloid leukemia_Homo sapiens_hsa052210.39474103
126Steroid biosynthesis_Homo sapiens_hsa001000.38519506
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37401169
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36246524
129Dopaminergic synapse_Homo sapiens_hsa047280.36188289
130Cholinergic synapse_Homo sapiens_hsa047250.36141338
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35561524
132Phototransduction_Homo sapiens_hsa047440.35207386
133Measles_Homo sapiens_hsa051620.35189263
134Vitamin B6 metabolism_Homo sapiens_hsa007500.33970906
135Hepatitis B_Homo sapiens_hsa051610.33412453
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32370697
137GABAergic synapse_Homo sapiens_hsa047270.32227472
138Phagosome_Homo sapiens_hsa041450.31374823
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31274928
140B cell receptor signaling pathway_Homo sapiens_hsa046620.31056266
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30929395
142Tuberculosis_Homo sapiens_hsa051520.30562393
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30530233
144Taste transduction_Homo sapiens_hsa047420.30332333
145Chemical carcinogenesis_Homo sapiens_hsa052040.30245513
146Insulin signaling pathway_Homo sapiens_hsa049100.29775155
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.29608344
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29398262
149Influenza A_Homo sapiens_hsa051640.28996849
150Circadian rhythm_Homo sapiens_hsa047100.28753486
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28656037
152Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27415319
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27134912
154Vibrio cholerae infection_Homo sapiens_hsa051100.26004368
155Arginine biosynthesis_Homo sapiens_hsa002200.25538651
156Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24361958

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