MBNL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.74810553
2axon ensheathment in central nervous system (GO:0032291)5.74810553
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.11770213
4axon ensheathment (GO:0008366)3.76844272
5ensheathment of neurons (GO:0007272)3.76844272
6myelination (GO:0042552)3.75401362
7regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.72352955
8sodium ion export (GO:0071436)3.69773630
9negative regulation of neurotransmitter secretion (GO:0046929)3.54817301
10fatty acid elongation (GO:0030497)3.52876855
11negative regulation of neurotransmitter transport (GO:0051589)3.51648436
12neuronal action potential propagation (GO:0019227)3.42055390
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41945901
14long-chain fatty acid biosynthetic process (GO:0042759)3.40436840
15cellular sodium ion homeostasis (GO:0006883)3.17713195
16negative regulation of protein localization to cell surface (GO:2000009)3.16523256
17myelin maintenance (GO:0043217)3.01632038
18desmosome organization (GO:0002934)2.99369268
19peptidyl-tyrosine autophosphorylation (GO:0038083)2.98539960
20cell communication by electrical coupling (GO:0010644)2.96558256
21positive regulation of cardiac muscle hypertrophy (GO:0010613)2.87886625
22positive regulation of muscle hypertrophy (GO:0014742)2.87886625
23eye photoreceptor cell differentiation (GO:0001754)2.87163894
24photoreceptor cell differentiation (GO:0046530)2.87163894
25neuron remodeling (GO:0016322)2.79794070
26synaptic vesicle maturation (GO:0016188)2.79428700
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78689557
28apical protein localization (GO:0045176)2.72498915
29presynaptic membrane organization (GO:0097090)2.69717601
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67735632
31positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67158230
32cellular potassium ion homeostasis (GO:0030007)2.66527754
33cerebellar granule cell differentiation (GO:0021707)2.66266458
34protein localization to endosome (GO:0036010)2.66115518
35L-amino acid import (GO:0043092)2.65918023
36presynaptic membrane assembly (GO:0097105)2.65199073
37asymmetric protein localization (GO:0008105)2.62932556
38neuron cell-cell adhesion (GO:0007158)2.60829561
39negative regulation of complement activation (GO:0045916)2.60136567
40nerve growth factor signaling pathway (GO:0038180)2.59596892
41negative regulation of dendrite morphogenesis (GO:0050774)2.59040095
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58675288
43cell communication involved in cardiac conduction (GO:0086065)2.58586989
44positive regulation of potassium ion transport (GO:0043268)2.57994349
45transmission of nerve impulse (GO:0019226)2.57406017
46regulation of synaptic vesicle exocytosis (GO:2000300)2.56170364
47negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.55712577
48synaptic vesicle exocytosis (GO:0016079)2.55242105
49regulation of voltage-gated calcium channel activity (GO:1901385)2.54574793
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53763918
51negative regulation of protein activation cascade (GO:2000258)2.50887891
52peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.48322489
53potassium ion import (GO:0010107)2.47312332
54creatine metabolic process (GO:0006600)2.46595253
55macroautophagy (GO:0016236)2.46207856
56regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.45304909
57mating behavior (GO:0007617)2.44646812
58negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44582082
59membrane assembly (GO:0071709)2.42485058
60glycine transport (GO:0015816)2.42299999
61response to methylmercury (GO:0051597)2.42162157
62regulation of cell communication by electrical coupling (GO:0010649)2.41921673
63oligodendrocyte differentiation (GO:0048709)2.41279650
64regulation of amyloid precursor protein catabolic process (GO:1902991)2.39731911
65regulation of short-term neuronal synaptic plasticity (GO:0048172)2.39541081
66relaxation of cardiac muscle (GO:0055119)2.38586100
67relaxation of muscle (GO:0090075)2.38245777
68establishment of mitochondrion localization (GO:0051654)2.37899398
69glutamate secretion (GO:0014047)2.37710132
70positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.36689324
71gamma-aminobutyric acid signaling pathway (GO:0007214)2.36621202
72Golgi to plasma membrane protein transport (GO:0043001)2.35010122
73neuron recognition (GO:0008038)2.34669923
74inositol phosphate-mediated signaling (GO:0048016)2.33612530
75positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.32672799
76negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.31784485
77ionotropic glutamate receptor signaling pathway (GO:0035235)2.31088049
78adult walking behavior (GO:0007628)2.31072604
79detection of temperature stimulus involved in sensory perception (GO:0050961)2.29548528
80detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.29548528
81virion attachment to host cell (GO:0019062)2.28849814
82adhesion of symbiont to host cell (GO:0044650)2.28849814
83regulation of sodium ion transmembrane transport (GO:1902305)2.27074287
84detection of calcium ion (GO:0005513)2.26493287
85import into cell (GO:0098657)2.26476179
86peripheral nervous system axon ensheathment (GO:0032292)2.26212150
87myelination in peripheral nervous system (GO:0022011)2.26212150
88magnesium ion transport (GO:0015693)2.24930787
89regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.24749692
90positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.23919962
91vesicle transport along microtubule (GO:0047496)2.23395614
92glutamate receptor signaling pathway (GO:0007215)2.22821411
93regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.20383442
94response to redox state (GO:0051775)2.20135480
95regulation of vesicle fusion (GO:0031338)2.19936912
96response to epinephrine (GO:0071871)2.19917773
97regulation of collateral sprouting (GO:0048670)2.19781472
98regulation of sodium ion transmembrane transporter activity (GO:2000649)2.19628368
99lung lobe morphogenesis (GO:0060463)2.19413275
100potassium ion homeostasis (GO:0055075)2.18901636
101tonic smooth muscle contraction (GO:0014820)2.17026150
102cellular response to epinephrine stimulus (GO:0071872)2.16354659
103regulation of transforming growth factor beta2 production (GO:0032909)2.16136691
104regulation of cholesterol homeostasis (GO:2000188)2.16107954
105negative regulation of synaptic transmission (GO:0050805)2.16058550
106positive regulation of fibroblast migration (GO:0010763)2.16018896
107endocrine hormone secretion (GO:0060986)2.15634828
108regulation of cardiac muscle hypertrophy (GO:0010611)2.15480994
109dendrite morphogenesis (GO:0048813)2.14764586
110neuronal ion channel clustering (GO:0045161)2.14629789
111cytoskeletal anchoring at plasma membrane (GO:0007016)2.14560676
112positive regulation of potassium ion transmembrane transport (GO:1901381)2.14511175
113negative regulation of JUN kinase activity (GO:0043508)2.14155038
114regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.14021656
115axonal fasciculation (GO:0007413)2.13475630
116substantia nigra development (GO:0021762)2.13465200
117cerebral cortex radially oriented cell migration (GO:0021799)2.13102594
118relaxation of smooth muscle (GO:0044557)2.12997894
119calcium-mediated signaling using intracellular calcium source (GO:0035584)2.12908293
120regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.12906471
121regulation of muscle hypertrophy (GO:0014743)2.12855497
122neuron-neuron synaptic transmission (GO:0007270)2.12187011
123regulation of muscle adaptation (GO:0043502)2.11958359
124organelle transport along microtubule (GO:0072384)2.11592685
125regulation of long-term neuronal synaptic plasticity (GO:0048169)2.11512499
126smooth muscle tissue development (GO:0048745)2.11146630
127regulation of synaptic vesicle transport (GO:1902803)2.11066779
128regulation of complement activation (GO:0030449)2.10938389
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.10766144
130positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.10594994
131regulation of calcium ion transmembrane transporter activity (GO:1901019)2.09909396
132regulation of calcium ion transmembrane transport (GO:1903169)2.09909396
133cellular response to catecholamine stimulus (GO:0071870)2.09622929
134cellular response to monoamine stimulus (GO:0071868)2.09622929
135regulation of neuronal synaptic plasticity (GO:0048168)2.09536432
136response to gravity (GO:0009629)2.08998099
137regulation of integrin-mediated signaling pathway (GO:2001044)2.08893640
138negative regulation of axonogenesis (GO:0050771)2.08699806
139astrocyte development (GO:0014002)2.08687917
140neuronal action potential (GO:0019228)2.08180575
141negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.08037709
142positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.07525529
143Golgi to endosome transport (GO:0006895)2.07290555
144cell adhesion mediated by integrin (GO:0033627)2.07017201
145regulation of dendritic spine morphogenesis (GO:0061001)2.06953957
146neurotransmitter secretion (GO:0007269)2.06951435
147locomotory exploration behavior (GO:0035641)2.06915678
148clathrin coat assembly (GO:0048268)2.06401854
149protein localization to synapse (GO:0035418)2.06346060
150regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.06006834
151retina vasculature morphogenesis in camera-type eye (GO:0061299)2.05582309
152regulation of energy homeostasis (GO:2000505)2.05158808
153regulation of protein activation cascade (GO:2000257)2.04857614
154regulation of clathrin-mediated endocytosis (GO:2000369)2.04187215
155COPII vesicle coating (GO:0048208)2.03844344
156regulation of lipoprotein metabolic process (GO:0050746)2.03582177
157skin morphogenesis (GO:0043589)2.01670058
158cardiac conduction (GO:0061337)2.00441287
159positive regulation of extracellular matrix organization (GO:1903055)1.96574170
160regulation of cardiac muscle cell contraction (GO:0086004)1.95477164
161sodium ion homeostasis (GO:0055078)1.95031470
162regulation of Rac protein signal transduction (GO:0035020)1.94643201
163endothelium development (GO:0003158)1.94548098
164positive regulation of glycolytic process (GO:0045821)1.92801040
165glomerular basement membrane development (GO:0032836)1.92203911
166cerebellar Purkinje cell differentiation (GO:0021702)1.91565451
167regulation of actin filament-based movement (GO:1903115)1.90484522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.08759724
2EZH2_22144423_ChIP-Seq_EOC_Human2.92307843
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60475767
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51701572
5SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25735018
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25676979
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20263395
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19966401
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19966401
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14155335
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07694009
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04172495
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.02767299
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02179472
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00069626
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94131130
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.93777901
18TAF15_26573619_Chip-Seq_HEK293_Human1.87344787
19* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85291693
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.84336391
21AR_21572438_ChIP-Seq_LNCaP_Human1.79166403
22* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73695472
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71905258
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71063267
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.70492801
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68050505
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67211061
28DROSHA_22980978_ChIP-Seq_HELA_Human1.64571310
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.64383291
30* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.62471307
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.59468927
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.58581682
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54990018
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54716970
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53466556
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52619847
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51350476
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51350476
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49488953
40SMAD4_21799915_ChIP-Seq_A2780_Human1.45547610
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.42585917
42VDR_22108803_ChIP-Seq_LS180_Human1.40959554
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40708544
44* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39768578
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38230524
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.38147276
47P300_19829295_ChIP-Seq_ESCs_Human1.37869994
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.37164635
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36578808
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36318293
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36009395
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.33779945
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33366480
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33331381
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32930334
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32272927
57* RARB_27405468_Chip-Seq_BRAIN_Mouse1.31763781
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31382878
59TP53_18474530_ChIP-ChIP_U2OS_Human1.31185896
60TP53_16413492_ChIP-PET_HCT116_Human1.30490960
61* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29323269
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28790669
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28600620
64AHR_22903824_ChIP-Seq_MCF-7_Human1.28479884
65* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28247143
66* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27177775
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.24763461
68ER_23166858_ChIP-Seq_MCF-7_Human1.23269800
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.22921720
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21534733
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20192274
72* SOX2_20726797_ChIP-Seq_SW620_Human1.20091159
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.18651061
74* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18010465
75STAT3_23295773_ChIP-Seq_U87_Human1.17858704
76REST_21632747_ChIP-Seq_MESCs_Mouse1.17847316
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.17737644
78* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17138750
79CLOCK_20551151_ChIP-Seq_293T_Human1.16582071
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15676993
81* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15225416
82* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14277250
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12108996
84* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11564474
85* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11525937
86* TBX20_22328084_ChIP-Seq_HEART_Mouse1.11451480
87* TBX20_22080862_ChIP-Seq_HEART_Mouse1.11451480
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09011856
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08945543
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08659326
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07943738
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07918773
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07835964
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.07683371
95* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06029531
96AR_25329375_ChIP-Seq_VCAP_Human1.05455663
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05261225
98* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04818476
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04699866
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.04523062
101BRD4_25478319_ChIP-Seq_HGPS_Human1.03557333
102TP63_23658742_ChIP-Seq_EP156T_Human1.03117452
103* ESR2_21235772_ChIP-Seq_MCF-7_Human1.01525479
104BCAT_22108803_ChIP-Seq_LS180_Human0.99055976
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98778175
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98479626
107CJUN_26792858_Chip-Seq_BT549_Human0.98188901
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98055834
109FUS_26573619_Chip-Seq_HEK293_Human0.98054484
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97887804
111RXR_22108803_ChIP-Seq_LS180_Human0.97452928
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96861054
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.96830345
114* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96789280
115* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95951743
116* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95951743
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95048533
118* TCF4_23295773_ChIP-Seq_U87_Human0.94855132
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94529955
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.94511074
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93218864
122RUNX2_22187159_ChIP-Seq_PCA_Human0.92721836
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92211757
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90933897
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89973526
126REST_18959480_ChIP-ChIP_MESCs_Mouse0.89654899
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.89283115
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89097013
129* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89014493
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.88542585
131ZNF274_21170338_ChIP-Seq_K562_Hela0.87970698
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.87608345
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.86908843
134* RING1B_27294783_Chip-Seq_ESCs_Mouse0.86653456
135IGF1R_20145208_ChIP-Seq_DFB_Human0.85736866
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.85617797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.60739741
2MP0003880_abnormal_central_pattern3.58964000
3MP0004859_abnormal_synaptic_plasticity3.30352191
4MP0000920_abnormal_myelination3.17379347
5MP0010368_abnormal_lymphatic_system2.65754589
6MP0002272_abnormal_nervous_system2.38131108
7MP0003635_abnormal_synaptic_transmissio2.34319071
8MP0003950_abnormal_plasma_membrane2.32319390
9MP0002064_seizures2.20124954
10MP0003329_amyloid_beta_deposits2.19860852
11MP0002734_abnormal_mechanical_nocicepti2.14599763
12MP0005171_absent_coat_pigmentation2.13944561
13MP0001968_abnormal_touch/_nociception2.10597694
14MP0009745_abnormal_behavioral_response2.09527622
15MP0009046_muscle_twitch2.00136266
16MP0003690_abnormal_glial_cell1.98708169
17MP0001486_abnormal_startle_reflex1.94882706
18MP0002735_abnormal_chemical_nociception1.94662739
19MP0000013_abnormal_adipose_tissue1.80437190
20MP0003868_abnormal_feces_composition1.80341489
21MP0010234_abnormal_vibrissa_follicle1.75993941
22MP0002063_abnormal_learning/memory/cond1.75582645
23MP0004145_abnormal_muscle_electrophysio1.74884879
24MP0009780_abnormal_chondrocyte_physiolo1.73468652
25MP0002736_abnormal_nociception_after1.73284363
26MP0008438_abnormal_cutaneous_collagen1.70359858
27MP0006138_congestive_heart_failure1.68788114
28MP0004885_abnormal_endolymph1.68003348
29MP0002837_dystrophic_cardiac_calcinosis1.66556828
30MP0002572_abnormal_emotion/affect_behav1.62991774
31MP0005167_abnormal_blood-brain_barrier1.62758752
32MP0001970_abnormal_pain_threshold1.62671436
33MP0003879_abnormal_hair_cell1.60091552
34MP0003634_abnormal_glial_cell1.59427850
35MP0002733_abnormal_thermal_nociception1.55895620
36MP0005623_abnormal_meninges_morphology1.54634073
37MP0001440_abnormal_grooming_behavior1.53401039
38MP0003279_aneurysm1.52695636
39MP0001501_abnormal_sleep_pattern1.50895109
40MP0001299_abnormal_eye_distance/1.50087524
41MP0000751_myopathy1.49782794
42MP0001905_abnormal_dopamine_level1.48550278
43MP0002822_catalepsy1.45908089
44MP0005670_abnormal_white_adipose1.42885755
45MP0004272_abnormal_basement_membrane1.41989657
46MP0003566_abnormal_cell_adhesion1.40723079
47MP0001879_abnormal_lymphatic_vessel1.40385460
48MP0004742_abnormal_vestibular_system1.39864173
49MP0002067_abnormal_sensory_capabilities1.39243263
50MP0005409_darkened_coat_color1.39105780
51MP0003633_abnormal_nervous_system1.38875724
52MP0000778_abnormal_nervous_system1.37997399
53MP0008569_lethality_at_weaning1.37950482
54MP0005423_abnormal_somatic_nervous1.30608007
55MP0000749_muscle_degeneration1.27726928
56MP0001529_abnormal_vocalization1.26552349
57MP0002229_neurodegeneration1.23856276
58MP0004142_abnormal_muscle_tone1.23593713
59MP0000747_muscle_weakness1.22501450
60MP0003191_abnormal_cellular_cholesterol1.22151179
61MP0003705_abnormal_hypodermis_morpholog1.21638146
62MP0000566_synostosis1.21443985
63MP0004858_abnormal_nervous_system1.20110370
64MP0003631_nervous_system_phenotype1.18943264
65MP0002877_abnormal_melanocyte_morpholog1.18257504
66MP0004924_abnormal_behavior1.16038880
67MP0005386_behavior/neurological_phenoty1.16038880
68MP0002896_abnormal_bone_mineralization1.14643655
69MP0010678_abnormal_skin_adnexa1.14508431
70MP0004043_abnormal_pH_regulation1.12270577
71MP0001485_abnormal_pinna_reflex1.11703366
72MP0006276_abnormal_autonomic_nervous1.11631647
73MP0000955_abnormal_spinal_cord1.11545590
74MP0000003_abnormal_adipose_tissue1.10398385
75MP0002882_abnormal_neuron_morphology1.10358603
76MP0003828_pulmonary_edema1.09185900
77MP0005646_abnormal_pituitary_gland1.08910871
78MP0002184_abnormal_innervation1.08265735
79MP0003091_abnormal_cell_migration1.08158746
80MP0008775_abnormal_heart_ventricle1.07636112
81MP0005275_abnormal_skin_tensile1.07555058
82MP0000569_abnormal_digit_pigmentation1.07152984
83MP0005551_abnormal_eye_electrophysiolog1.06718285
84MP0003045_fibrosis1.06181419
85MP0000604_amyloidosis1.06039105
86MP0004484_altered_response_of1.05397539
87MP0002295_abnormal_pulmonary_circulatio1.04915384
88MP0005023_abnormal_wound_healing1.03988705
89MP0002909_abnormal_adrenal_gland1.02941300
90MP0002971_abnormal_brown_adipose1.02775577
91MP0002066_abnormal_motor_capabilities/c1.02678001
92MP0008004_abnormal_stomach_pH1.02571697
93MP0005165_increased_susceptibility_to1.02241923
94MP0003632_abnormal_nervous_system1.01465981
95MP0004215_abnormal_myocardial_fiber0.97834237
96MP0005620_abnormal_muscle_contractility0.97772438
97* MP0004036_abnormal_muscle_relaxation0.97005178
98MP0002876_abnormal_thyroid_physiology0.96672386
99MP0002090_abnormal_vision0.95817862
100MP0004085_abnormal_heartbeat0.93901624
101* MP0004087_abnormal_muscle_fiber0.93441025
102MP0004134_abnormal_chest_morphology0.91372602
103MP0005375_adipose_tissue_phenotype0.89938040
104MP0001502_abnormal_circadian_rhythm0.89190594
105MP0003136_yellow_coat_color0.88630530
106MP0003195_calcinosis0.88603582
107MP0002332_abnormal_exercise_endurance0.88061914
108MP0001177_atelectasis0.87901172
109MP0002108_abnormal_muscle_morphology0.87250263
110MP0005365_abnormal_bile_salt0.86626113
111MP0004147_increased_porphyrin_level0.85156437
112MP0002972_abnormal_cardiac_muscle0.83844343
113MP0009384_cardiac_valve_regurgitation0.83798863
114MP0002269_muscular_atrophy0.83338905
115MP0001984_abnormal_olfaction0.83336250
116MP0005503_abnormal_tendon_morphology0.83273920
117MP0010386_abnormal_urinary_bladder0.81755233
118MP0010329_abnormal_lipoprotein_level0.81572948
119MP0010352_gastrointestinal_tract_polyps0.81305063
120MP0000639_abnormal_adrenal_gland0.80951049
121MP0001666_abnormal_nutrient_absorption0.80711421
122MP0002168_other_aberrant_phenotype0.80697353
123MP0008875_abnormal_xenobiotic_pharmacok0.80346994
124MP0003137_abnormal_impulse_conducting0.80083146
125MP0001346_abnormal_lacrimal_gland0.80023988
126MP0002557_abnormal_social/conspecific_i0.79289266
127MP0003075_altered_response_to0.79108243
128MP0001958_emphysema0.78760669
129MP0004811_abnormal_neuron_physiology0.78719045
130MP0001544_abnormal_cardiovascular_syste0.78234216
131MP0005385_cardiovascular_system_phenoty0.78234216
132MP0004130_abnormal_muscle_cell0.77118633
133MP0000372_irregular_coat_pigmentation0.76713305
134MP0000383_abnormal_hair_follicle0.74934876
135MP0005330_cardiomyopathy0.74625635
136MP0004084_abnormal_cardiac_muscle0.74308840
137MP0001963_abnormal_hearing_physiology0.72300732
138MP0002752_abnormal_somatic_nervous0.72047599
139MP0005595_abnormal_vascular_smooth0.71862321

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.78823349
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.16895039
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.16895039
4Focal motor seizures (HP:0011153)3.77155254
5Cerebral inclusion bodies (HP:0100314)3.74304610
6Myokymia (HP:0002411)3.64376076
7Termporal pattern (HP:0011008)3.52204172
8Insidious onset (HP:0003587)3.52204172
9Supranuclear gaze palsy (HP:0000605)3.51097592
10Aortic aneurysm (HP:0004942)3.45701839
11Febrile seizures (HP:0002373)3.33955690
12Aortic dissection (HP:0002647)3.27658530
13Protrusio acetabuli (HP:0003179)3.25086504
14Onion bulb formation (HP:0003383)3.23975591
15Action tremor (HP:0002345)3.23212744
16Abnormality of the corticospinal tract (HP:0002492)3.10997837
17Bundle branch block (HP:0011710)3.09724096
18Mitral stenosis (HP:0001718)2.98237038
19Hyporeflexia of lower limbs (HP:0002600)2.97615245
20Pheochromocytoma (HP:0002666)2.97399644
21Sensory axonal neuropathy (HP:0003390)2.93381443
22Peripheral hypomyelination (HP:0007182)2.93015942
23Focal seizures (HP:0007359)2.92622270
24Dysmetria (HP:0001310)2.90892539
25Atonic seizures (HP:0010819)2.89009454
26Retinal dysplasia (HP:0007973)2.81521219
27Right ventricular cardiomyopathy (HP:0011663)2.78892249
28Scanning speech (HP:0002168)2.75039526
29Ankle clonus (HP:0011448)2.73560069
30Intention tremor (HP:0002080)2.65440445
31Cerebral aneurysm (HP:0004944)2.63258073
32Aplasia involving bones of the upper limbs (HP:0009823)2.62692405
33Aplasia of the phalanges of the hand (HP:0009802)2.62692405
34Aplasia involving bones of the extremities (HP:0009825)2.62692405
35Muscle fiber splitting (HP:0003555)2.60236614
36Neuroendocrine neoplasm (HP:0100634)2.53998447
37Ulnar claw (HP:0001178)2.53201515
38Segmental peripheral demyelination/remyelination (HP:0003481)2.50424698
39Type 1 muscle fiber predominance (HP:0003803)2.49370542
40Parakeratosis (HP:0001036)2.49028294
41Thickened helices (HP:0000391)2.46706209
42Striae distensae (HP:0001065)2.43881523
43Foot dorsiflexor weakness (HP:0009027)2.41012277
44Muscle hypertrophy of the lower extremities (HP:0008968)2.40424532
45Abnormality of binocular vision (HP:0011514)2.39684218
46Diplopia (HP:0000651)2.39684218
47Nemaline bodies (HP:0003798)2.39376554
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.35862364
49Osteolytic defects of the hand bones (HP:0009699)2.35862364
50Spastic gait (HP:0002064)2.34690782
51Cerebral hemorrhage (HP:0001342)2.33569198
52Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.33404229
53Muscle fiber inclusion bodies (HP:0100299)2.33075976
54Epileptic encephalopathy (HP:0200134)2.30139246
55Cardiovascular calcification (HP:0011915)2.29747335
56Abnormal atrioventricular conduction (HP:0005150)2.26050739
57Hammertoe (HP:0001765)2.20750064
58Hypoplasia of the iris (HP:0007676)2.20484519
59Dialeptic seizures (HP:0011146)2.18727877
60Complement deficiency (HP:0004431)2.17488651
61Wormian bones (HP:0002645)2.16889875
62Heart block (HP:0012722)2.16675529
63Steppage gait (HP:0003376)2.16170905
64Abnormality of the foot musculature (HP:0001436)2.14213178
65Overgrowth (HP:0001548)2.12226829
66Autoamputation (HP:0001218)2.11335320
67Exercise-induced myalgia (HP:0003738)2.11287504
68Lower limb muscle weakness (HP:0007340)2.10912820
69Premature rupture of membranes (HP:0001788)2.10792046
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10387277
71Progressive cerebellar ataxia (HP:0002073)2.08768545
72Alacrima (HP:0000522)2.08577816
73Buphthalmos (HP:0000557)2.08478226
74Axonal loss (HP:0003447)2.07190294
75Absence seizures (HP:0002121)2.07014120
76Difficulty running (HP:0009046)2.06121605
77Papillary thyroid carcinoma (HP:0002895)2.05492125
78Infantile muscular hypotonia (HP:0008947)2.03576529
79Increased variability in muscle fiber diameter (HP:0003557)2.03029061
80Atrioventricular block (HP:0001678)2.02443944
81Dysdiadochokinesis (HP:0002075)2.01598541
82Calf muscle hypertrophy (HP:0008981)2.00722831
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00110849
84Vascular calcification (HP:0004934)1.99712088
85Truncal ataxia (HP:0002078)1.99549357
86Megalencephaly (HP:0001355)1.99110223
87Clumsiness (HP:0002312)1.98262936
88Anxiety (HP:0000739)1.96407480
89Increased circulating renin level (HP:0000848)1.95187402
90Generalized tonic-clonic seizures (HP:0002069)1.94656886
91Gowers sign (HP:0003391)1.94048191
92Atrial fibrillation (HP:0005110)1.93690127
93Rapidly progressive (HP:0003678)1.93412899
94Tetraparesis (HP:0002273)1.92651020
95Broad metatarsal (HP:0001783)1.92511404
96Abnormal auditory evoked potentials (HP:0006958)1.91809531
97Obstructive sleep apnea (HP:0002870)1.91718773
98Dysmetric saccades (HP:0000641)1.91211170
99Papilledema (HP:0001085)1.90034747
100Aneurysm (HP:0002617)1.87066232
101Abnormality of the calf musculature (HP:0001430)1.87009806
102Visual hallucinations (HP:0002367)1.86916214
103Slow saccadic eye movements (HP:0000514)1.86044121
104EMG: myopathic abnormalities (HP:0003458)1.85357300
105Prolonged QT interval (HP:0001657)1.85336081
106Blue irides (HP:0000635)1.85328631
107Macroorchidism (HP:0000053)1.85178296
108Decreased motor nerve conduction velocity (HP:0003431)1.84402337
109Ventricular fibrillation (HP:0001663)1.84152460
110Broad-based gait (HP:0002136)1.83844840
111Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.83708470
112Anteriorly placed anus (HP:0001545)1.83624742
113Type II lissencephaly (HP:0007260)1.83013073
114Ventricular arrhythmia (HP:0004308)1.82748902
115Stridor (HP:0010307)1.80992592
116Hemiparesis (HP:0001269)1.80025958
117Abnormality of the left ventricular outflow tract (HP:0011103)1.78066018
118Subaortic stenosis (HP:0001682)1.78066018
119Neck muscle weakness (HP:0000467)1.77333701
120Bradycardia (HP:0001662)1.76306800
121Sudden death (HP:0001699)1.75738824
122Menstrual irregularities (HP:0000858)1.74252497
123Scapular winging (HP:0003691)1.74239849
124Gaze-evoked nystagmus (HP:0000640)1.73676054
125Akinesia (HP:0002304)1.72572312
126Primary atrial arrhythmia (HP:0001692)1.72482174
127Acanthosis nigricans (HP:0000956)1.70448094
128Insulin-resistant diabetes mellitus (HP:0000831)1.69931150
129Round ear (HP:0100830)1.68743104
130Humeroradial synostosis (HP:0003041)1.68325218
131Synostosis involving the elbow (HP:0003938)1.68325218
132Mildly elevated creatine phosphokinase (HP:0008180)1.67289629
133White forelock (HP:0002211)1.67067015
134Syncope (HP:0001279)1.66708795
135Hyperkalemia (HP:0002153)1.65831683
136Postural tremor (HP:0002174)1.65676354
137Postural instability (HP:0002172)1.65593071
138Distal sensory impairment (HP:0002936)1.65149629
139Urinary urgency (HP:0000012)1.65137683
140Increased connective tissue (HP:0009025)1.65035910
141Spondylolisthesis (HP:0003302)1.64911269
142Abnormality of complement system (HP:0005339)1.64794597
143Metabolic alkalosis (HP:0200114)1.64148148
144Arterial tortuosity (HP:0005116)1.63896292
145Submucous cleft hard palate (HP:0000176)1.63828931
146Limited hip movement (HP:0008800)1.63793090
147Vascular tortuosity (HP:0004948)1.63303681
148Testicular neoplasm (HP:0010788)1.63244954
149Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62824870
150Hyperventilation (HP:0002883)1.62622573
151Cervical subluxation (HP:0003308)1.62478368
152Myotonia (HP:0002486)1.61199780
153Metaphyseal dysplasia (HP:0100255)1.61099852
154Spinal rigidity (HP:0003306)1.60521809
155Atrophic scars (HP:0001075)1.60303773
156Coronal craniosynostosis (HP:0004440)1.59936789
157Hypoalphalipoproteinemia (HP:0003233)1.59932063
158Torticollis (HP:0000473)1.59400386
159Abnormality of the intrinsic pathway (HP:0010989)1.58393208
160Supraventricular arrhythmia (HP:0005115)1.57440878
161Shallow orbits (HP:0000586)1.56831631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.48502928
2OXSR13.05604839
3EPHA42.49893520
4NTRK12.49495277
5EPHB12.36224568
6WNK42.35600843
7RIPK12.35321838
8AKT32.28289249
9NTRK32.21498754
10MAPKAPK52.03177432
11WNK11.99312240
12LATS21.90740962
13BCR1.77276666
14MST1R1.71624014
15RIPK41.71360441
16FGFR21.62777165
17MET1.59246356
18KSR21.58333205
19MAP3K21.55985873
20MAP3K91.54496207
21TGFBR21.51765503
22CAMK2D1.47383340
23ARAF1.45971088
24CAMK2B1.45455990
25TNIK1.45371502
26PKN11.39430398
27PAK61.37885876
28CASK1.36610459
29LATS11.35978471
30LIMK11.31915467
31SGK21.31442322
32PAK31.31016705
33EPHA21.30587059
34PDGFRA1.30281845
35PHKG11.27229810
36PHKG21.27229810
37SGK31.24417221
38STK381.23931236
39SGK4941.22002892
40SGK2231.22002892
41CDK191.21806710
42MAPK151.19489184
43MINK11.19332138
44ROCK21.16937673
45MAP3K131.15485532
46FER1.14875076
47MARK11.14484929
48CAMK2A1.13098762
49UHMK11.11684760
50CDK51.10477941
51FGFR31.09964168
52PNCK1.09192096
53GRK51.08111005
54DMPK1.05420639
55PRKCE1.05382570
56NEK61.04972850
57PTK2B1.04770219
58STK241.04181355
59JAK11.03448147
60TRPM71.01924891
61CAMK2G1.01700959
62STK38L1.00753891
63MAPK120.99774959
64ERBB30.96680689
65FGR0.92256138
66PIK3CA0.91426822
67DDR20.89468432
68SCYL20.89160323
69MUSK0.88987341
70CSNK1G20.88555325
71CSNK1A1L0.88430217
72PBK0.88245262
73PLK20.88187562
74MAP3K40.87526449
75PRKD10.87486397
76PRPF4B0.85169395
77MAPK70.85008273
78PIK3CG0.84625327
79PDPK10.84354497
80BMPR20.83585602
81CAMKK20.83328512
82MAP3K10.82256623
83OBSCN0.82202477
84DAPK20.80772487
85GRK70.80387646
86LMTK20.80005508
87MARK20.76471588
88CAMK1G0.76418926
89MAP3K70.74726432
90RET0.74335915
91NEK90.73456853
92CSNK1G30.73393672
93CDK140.72955090
94WNK30.71359884
95MST40.71090563
96PRKAA20.70307395
97PRKCH0.69497693
98BMPR1B0.69438959
99PRKCQ0.66767835
100PRKD30.65453147
101NTRK20.64450293
102MAP2K40.64004425
103NLK0.62107511
104MAP2K10.60491053
105PINK10.59071967
106MOS0.58857886
107FYN0.58145736
108EPHA30.58057908
109CAMKK10.57651859
110TTN0.57191643
111CSNK1G10.57182080
112PAK20.55551973
113MAP3K30.55061641
114KSR10.54781443
115CDK150.52546523
116PRKG10.51220129
117PDGFRB0.51028037
118SGK10.50615937
119CDK180.50600032
120FES0.50344224
121GRK10.49865576
122PDK10.49443375
123TIE10.48698114
124MYLK0.48260679
125MAP2K70.47961318
126MAPKAPK30.47890246
127FRK0.46752056
128PTK20.46049544
129FGFR10.45877768
130MAP3K120.45578284
131CAMK10.45535539
132MAPK100.45261451
133ROCK10.44573213
134PRKAA10.44369897
135NME10.44141294
136RPS6KA30.43427846

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047102.06521761
2GABAergic synapse_Homo sapiens_hsa047271.88314716
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84672989
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81473422
5Glutamatergic synapse_Homo sapiens_hsa047241.81061146
6Circadian entrainment_Homo sapiens_hsa047131.80462932
7Fatty acid elongation_Homo sapiens_hsa000621.71688670
8Morphine addiction_Homo sapiens_hsa050321.68620542
9Nicotine addiction_Homo sapiens_hsa050331.66354455
10Salivary secretion_Homo sapiens_hsa049701.63475631
11Serotonergic synapse_Homo sapiens_hsa047261.63390954
12Synaptic vesicle cycle_Homo sapiens_hsa047211.60833389
13Olfactory transduction_Homo sapiens_hsa047401.58374524
14Long-term potentiation_Homo sapiens_hsa047201.54215775
15Renin secretion_Homo sapiens_hsa049241.54024928
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50070230
17Amphetamine addiction_Homo sapiens_hsa050311.49826491
18Gastric acid secretion_Homo sapiens_hsa049711.48253235
19Long-term depression_Homo sapiens_hsa047301.47022457
20Dopaminergic synapse_Homo sapiens_hsa047281.45989789
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42159175
22Insulin secretion_Homo sapiens_hsa049111.40943067
23Complement and coagulation cascades_Homo sapiens_hsa046101.39756613
24Cholinergic synapse_Homo sapiens_hsa047251.33902066
25Cocaine addiction_Homo sapiens_hsa050301.29985623
26Axon guidance_Homo sapiens_hsa043601.29750210
27Cardiac muscle contraction_Homo sapiens_hsa042601.29138145
28Ether lipid metabolism_Homo sapiens_hsa005651.28822498
29Taste transduction_Homo sapiens_hsa047421.28799231
30Bile secretion_Homo sapiens_hsa049761.28677506
31Vibrio cholerae infection_Homo sapiens_hsa051101.28444894
32Collecting duct acid secretion_Homo sapiens_hsa049661.27411852
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27067798
34Steroid biosynthesis_Homo sapiens_hsa001001.26623632
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.23554793
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22639832
37Dilated cardiomyopathy_Homo sapiens_hsa054141.20322310
38Oxidative phosphorylation_Homo sapiens_hsa001901.20140316
39Oxytocin signaling pathway_Homo sapiens_hsa049211.19077923
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16589700
41Sulfur metabolism_Homo sapiens_hsa009201.16274391
42Calcium signaling pathway_Homo sapiens_hsa040201.13938919
43Pancreatic secretion_Homo sapiens_hsa049721.13079110
44Alzheimers disease_Homo sapiens_hsa050101.12937354
45Dorso-ventral axis formation_Homo sapiens_hsa043201.08289994
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05741833
47ABC transporters_Homo sapiens_hsa020101.05654024
48cAMP signaling pathway_Homo sapiens_hsa040241.05534206
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03215067
50Sphingolipid metabolism_Homo sapiens_hsa006001.03031900
51Arginine biosynthesis_Homo sapiens_hsa002201.02136195
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01267492
53GnRH signaling pathway_Homo sapiens_hsa049121.00117177
54Gap junction_Homo sapiens_hsa045400.99645709
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98652218
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98589886
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96656892
58Inositol phosphate metabolism_Homo sapiens_hsa005620.94768679
59Glucagon signaling pathway_Homo sapiens_hsa049220.93698854
60ECM-receptor interaction_Homo sapiens_hsa045120.92545884
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92344319
62Phototransduction_Homo sapiens_hsa047440.91863132
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91618013
64Adherens junction_Homo sapiens_hsa045200.89796499
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88092232
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87988827
67Nitrogen metabolism_Homo sapiens_hsa009100.87250028
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86788844
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86696184
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86608442
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.84461599
72PPAR signaling pathway_Homo sapiens_hsa033200.84182904
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83641882
74Renal cell carcinoma_Homo sapiens_hsa052110.83192221
75Parkinsons disease_Homo sapiens_hsa050120.82428675
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.81554298
77Fatty acid biosynthesis_Homo sapiens_hsa000610.80663707
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80455554
79Melanogenesis_Homo sapiens_hsa049160.79968911
80Vitamin B6 metabolism_Homo sapiens_hsa007500.77628544
81Tight junction_Homo sapiens_hsa045300.77172437
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76853124
83Ras signaling pathway_Homo sapiens_hsa040140.76755011
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76114669
85Rheumatoid arthritis_Homo sapiens_hsa053230.75764035
86ErbB signaling pathway_Homo sapiens_hsa040120.75395491
87Proteoglycans in cancer_Homo sapiens_hsa052050.75151541
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74555793
89Mineral absorption_Homo sapiens_hsa049780.73072933
90Estrogen signaling pathway_Homo sapiens_hsa049150.72773984
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.72447580
92Thyroid hormone synthesis_Homo sapiens_hsa049180.72111460
93Endocytosis_Homo sapiens_hsa041440.71088630
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71036925
95beta-Alanine metabolism_Homo sapiens_hsa004100.70745832
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69444266
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.69375636
98Protein export_Homo sapiens_hsa030600.69329279
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67844777
100Ovarian steroidogenesis_Homo sapiens_hsa049130.66777812
101Phenylalanine metabolism_Homo sapiens_hsa003600.66466696
102Arginine and proline metabolism_Homo sapiens_hsa003300.64926032
103Choline metabolism in cancer_Homo sapiens_hsa052310.63357333
104Type II diabetes mellitus_Homo sapiens_hsa049300.62301945
105Focal adhesion_Homo sapiens_hsa045100.61410299
106Rap1 signaling pathway_Homo sapiens_hsa040150.60636980
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60140686
108Lysosome_Homo sapiens_hsa041420.59969575
109Phagosome_Homo sapiens_hsa041450.59777210
110AMPK signaling pathway_Homo sapiens_hsa041520.59373365
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.59181293
112Insulin resistance_Homo sapiens_hsa049310.58106401
113Fatty acid degradation_Homo sapiens_hsa000710.57688215
114MAPK signaling pathway_Homo sapiens_hsa040100.56885557
115Amoebiasis_Homo sapiens_hsa051460.55054193
116Insulin signaling pathway_Homo sapiens_hsa049100.54941956
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54885461
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53716586
119Glioma_Homo sapiens_hsa052140.53334394
120Protein digestion and absorption_Homo sapiens_hsa049740.53164609
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51320868
122Tyrosine metabolism_Homo sapiens_hsa003500.50828736
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49459258
124Salmonella infection_Homo sapiens_hsa051320.48454363
125mTOR signaling pathway_Homo sapiens_hsa041500.48352549
126VEGF signaling pathway_Homo sapiens_hsa043700.47199775
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47157882
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.44337694
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43458616
130African trypanosomiasis_Homo sapiens_hsa051430.41057122
131Platelet activation_Homo sapiens_hsa046110.40629952
132Prion diseases_Homo sapiens_hsa050200.38115023
133Histidine metabolism_Homo sapiens_hsa003400.36867079
134Linoleic acid metabolism_Homo sapiens_hsa005910.36750408

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