MBNL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)6.41246375
2plasma lipoprotein particle assembly (GO:0034377)5.41883517
3regulation of protein activation cascade (GO:2000257)5.26621994
4regulation of complement activation (GO:0030449)5.18467890
5negative regulation of fibrinolysis (GO:0051918)5.01502494
6negative regulation of protein activation cascade (GO:2000258)4.85495105
7protein-lipid complex assembly (GO:0065005)4.76659790
8hepatocyte apoptotic process (GO:0097284)4.49870832
9detection of molecule of bacterial origin (GO:0032490)4.47242609
10low-density lipoprotein particle remodeling (GO:0034374)4.42771651
11negative regulation of complement activation (GO:0045916)4.38508186
12regulation of fibrinolysis (GO:0051917)4.35836284
13microglial cell activation (GO:0001774)4.07199578
14complement activation, alternative pathway (GO:0006957)4.00766742
15regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.98367698
16blood coagulation, intrinsic pathway (GO:0007597)3.96111399
17meiotic chromosome segregation (GO:0045132)3.94466285
18plasma lipoprotein particle organization (GO:0071827)3.89296291
19kinetochore organization (GO:0051383)3.87109413
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.86329971
21negative regulation of cell killing (GO:0031342)3.86329971
22regulation of nuclear cell cycle DNA replication (GO:0033262)3.86071687
23regulation of DNA endoreduplication (GO:0032875)3.81943707
24negative regulation of humoral immune response (GO:0002921)3.80046782
25telomere maintenance via semi-conservative replication (GO:0032201)3.72493920
26regulation of humoral immune response (GO:0002920)3.71213590
27DNA replication checkpoint (GO:0000076)3.68942423
28peptidyl-glutamic acid carboxylation (GO:0017187)3.66704817
29protein carboxylation (GO:0018214)3.66704817
30regulation of gamma-delta T cell differentiation (GO:0045586)3.66484728
31negative regulation of phagocytosis (GO:0050765)3.65500377
32protein-lipid complex subunit organization (GO:0071825)3.62967423
33cholesterol efflux (GO:0033344)3.58493252
34plasma lipoprotein particle remodeling (GO:0034369)3.52801759
35protein-lipid complex remodeling (GO:0034368)3.52801759
36macromolecular complex remodeling (GO:0034367)3.52801759
37regulation of gamma-delta T cell activation (GO:0046643)3.51366135
38kinetochore assembly (GO:0051382)3.51179058
39telomere maintenance via recombination (GO:0000722)3.51157384
40positive regulation of insulin receptor signaling pathway (GO:0046628)3.50207289
41regulation of cholesterol esterification (GO:0010872)3.50153101
42phospholipid homeostasis (GO:0055091)3.48708181
43DNA replication initiation (GO:0006270)3.48284575
44negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.47595130
45mitotic recombination (GO:0006312)3.43327872
46DNA strand elongation involved in DNA replication (GO:0006271)3.41906979
47CENP-A containing nucleosome assembly (GO:0034080)3.41651427
48response to interleukin-15 (GO:0070672)3.40977472
49DNA strand elongation (GO:0022616)3.39041209
50positive regulation of blood coagulation (GO:0030194)3.38121375
51positive regulation of hemostasis (GO:1900048)3.38121375
52positive regulation of DNA-dependent DNA replication (GO:2000105)3.37696117
53regulation of apoptotic cell clearance (GO:2000425)3.34689532
54phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.32507753
55histone H3-K36 demethylation (GO:0070544)3.32434543
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.32342701
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31189566
58positive regulation by organism of defense response of other organism involved in symbiotic interact3.31189566
59modulation by symbiont of host immune response (GO:0052553)3.31189566
60positive regulation by symbiont of host defense response (GO:0052509)3.31189566
61modulation by symbiont of host defense response (GO:0052031)3.31189566
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31189566
63chromatin remodeling at centromere (GO:0031055)3.30056035
64high-density lipoprotein particle remodeling (GO:0034375)3.27347933
65interferon-gamma production (GO:0032609)3.27046711
66daunorubicin metabolic process (GO:0044597)3.26757872
67polyketide metabolic process (GO:0030638)3.26757872
68doxorubicin metabolic process (GO:0044598)3.26757872
69detection of external biotic stimulus (GO:0098581)3.24035143
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23254121
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23157279
72cellular extravasation (GO:0045123)3.19434113
73ribosomal small subunit assembly (GO:0000028)3.18364113
74triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.17091590
75positive regulation of granulocyte differentiation (GO:0030854)3.16886612
76nuclear pore complex assembly (GO:0051292)3.15000406
77negative T cell selection (GO:0043383)3.13495485
78positive regulation of coagulation (GO:0050820)3.13232836
79cellular response to ethanol (GO:0071361)3.12549472
80intestinal cholesterol absorption (GO:0030299)3.12479209
81protein localization to kinetochore (GO:0034501)3.10646873
82mitotic sister chromatid cohesion (GO:0007064)3.09587496
83DNA synthesis involved in DNA repair (GO:0000731)3.08866976
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.05778548
85telomere maintenance via telomere lengthening (GO:0010833)3.04217757
86B cell receptor signaling pathway (GO:0050853)3.02748990
87replication fork processing (GO:0031297)3.00740866
88positive T cell selection (GO:0043368)3.00414244
89reverse cholesterol transport (GO:0043691)2.98817831
90negative thymic T cell selection (GO:0045060)2.98091680
91protein activation cascade (GO:0072376)2.97165192
92macrophage activation (GO:0042116)2.96655716
93DNA replication-independent nucleosome organization (GO:0034724)2.95890850
94DNA replication-independent nucleosome assembly (GO:0006336)2.95890850
95nucleotide-excision repair, DNA gap filling (GO:0006297)2.93720517
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93505230
97embryonic process involved in female pregnancy (GO:0060136)2.92717384
98lipoprotein metabolic process (GO:0042157)2.92580587
99plasma lipoprotein particle clearance (GO:0034381)2.90144213
100leukocyte migration involved in inflammatory response (GO:0002523)2.89941802
101telomere maintenance (GO:0000723)2.88170662
102phospholipid efflux (GO:0033700)2.87112481
103regulation of necroptotic process (GO:0060544)2.85867678
104DNA unwinding involved in DNA replication (GO:0006268)2.85723267
105DNA strand renaturation (GO:0000733)2.84672037
106telomere organization (GO:0032200)2.84466063
107negative regulation of lymphocyte mediated immunity (GO:0002707)2.82374685
108pore complex assembly (GO:0046931)2.82046514
109negative regulation of immunoglobulin mediated immune response (GO:0002890)2.80400012
110negative regulation of B cell mediated immunity (GO:0002713)2.80400012
111macrophage activation involved in immune response (GO:0002281)2.79968329
112detection of biotic stimulus (GO:0009595)2.79741148
113positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.79201970
114regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.79057825
115acute-phase response (GO:0006953)2.78650633
116positive thymic T cell selection (GO:0045059)2.75953386
117regulation of beta-amyloid formation (GO:1902003)2.75905604
118L-phenylalanine catabolic process (GO:0006559)2.74947070
119erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.74947070
120complement activation, classical pathway (GO:0006958)2.74745407
121positive regulation of receptor recycling (GO:0001921)2.74541507
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73166829
123mismatch repair (GO:0006298)2.71518238
124nuclear pore organization (GO:0006999)2.71145399
125positive regulation of defense response to virus by host (GO:0002230)2.70979318
126low-density lipoprotein particle clearance (GO:0034383)2.70655142
127DNA topological change (GO:0006265)2.70587955
128negative regulation of sterol transport (GO:0032372)2.70139877
129negative regulation of cholesterol transport (GO:0032375)2.70139877
130antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69702770
131protein localization to chromosome, centromeric region (GO:0071459)2.69583846
132positive regulation of gamma-delta T cell activation (GO:0046645)2.68720053
133positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.68030270
134DNA ligation (GO:0006266)2.67251410
135regulation of DNA-dependent DNA replication (GO:0090329)2.63786531
136translesion synthesis (GO:0019985)2.63277872
137negative regulation of B cell proliferation (GO:0030889)2.60806705
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60467888
139mitotic sister chromatid segregation (GO:0000070)2.59546687
140regulation of cholesterol homeostasis (GO:2000188)2.58996224
141fibrinolysis (GO:0042730)2.58764181
142positive regulation of humoral immune response (GO:0002922)2.58719298
143sister chromatid segregation (GO:0000819)2.58577923
144response to methylmercury (GO:0051597)2.57566953
145positive regulation of cellular response to insulin stimulus (GO:1900078)2.57565915
146detection of other organism (GO:0098543)2.57306292
147antigen processing and presentation of endogenous antigen (GO:0019883)2.57025002
148negative regulation of cell cycle G2/M phase transition (GO:1902750)2.55403755
149regulation of double-strand break repair via homologous recombination (GO:0010569)2.55264526
150protein K6-linked ubiquitination (GO:0085020)2.53043649
151DNA duplex unwinding (GO:0032508)2.48560976
152deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48181655
153intra-S DNA damage checkpoint (GO:0031573)2.47867195
154DNA geometric change (GO:0032392)2.47458180
155regulation of mitotic spindle checkpoint (GO:1903504)2.47020754
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47020754
157regulation of B cell receptor signaling pathway (GO:0050855)2.46308558
158attachment of spindle microtubules to kinetochore (GO:0008608)2.44685140
159definitive hemopoiesis (GO:0060216)2.44622690
160superoxide anion generation (GO:0042554)2.44435680
161DNA catabolic process, exonucleolytic (GO:0000738)2.42468678
162V(D)J recombination (GO:0033151)2.40960778
163establishment of chromosome localization (GO:0051303)2.40634099
164histone exchange (GO:0043486)2.40584835
165dendritic cell chemotaxis (GO:0002407)2.39858696
166sister chromatid cohesion (GO:0007062)2.38151795
167replicative senescence (GO:0090399)2.37736668
168mitotic chromosome condensation (GO:0007076)2.36595262
169mitotic metaphase plate congression (GO:0007080)2.35195185
170DNA replication (GO:0006260)2.34965152
171mitotic G2/M transition checkpoint (GO:0044818)2.34077190
172negative regulation of mast cell activation (GO:0033004)2.33420106
173histone mRNA catabolic process (GO:0071044)2.33220139
174reciprocal DNA recombination (GO:0035825)2.32222114
175reciprocal meiotic recombination (GO:0007131)2.32222114
176negative regulation of granulocyte differentiation (GO:0030853)2.31804274
177DNA-dependent DNA replication (GO:0006261)2.31350123
178centriole assembly (GO:0098534)2.30822331
179chromosome segregation (GO:0007059)2.30653038
180DNA double-strand break processing (GO:0000729)2.29861990
181metaphase plate congression (GO:0051310)2.29748080
182dendritic cell migration (GO:0036336)2.27394474
183mitotic nuclear envelope disassembly (GO:0007077)2.26927650
184chromatin assembly or disassembly (GO:0006333)2.26561143
185negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.26421539
186DNA conformation change (GO:0071103)2.24568050
187RNA-dependent DNA replication (GO:0006278)2.24366404
188DNA recombination (GO:0006310)2.22460218
189recombinational repair (GO:0000725)2.20888189
190neural tube formation (GO:0001841)2.20422283
191IMP biosynthetic process (GO:0006188)2.20239206
192neutrophil mediated immunity (GO:0002446)2.19447896
193myeloid dendritic cell activation (GO:0001773)2.19379406
194somatic cell DNA recombination (GO:0016444)2.19067767
195somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.19067767
196snRNA processing (GO:0016180)2.18784346
197DNA integration (GO:0015074)2.18378536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.22500316
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.70205501
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.49556247
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21753456
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.99650804
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88846484
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87403974
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.78786883
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76905269
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.75554081
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.71402682
12GATA1_22025678_ChIP-Seq_K562_Human2.63721917
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62093168
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56503443
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.55888134
16FOXA2_19822575_ChIP-Seq_HepG2_Human2.54943761
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.40631841
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.38098781
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.25276105
20SCL_19346495_ChIP-Seq_HPC-7_Human2.24473001
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.17382873
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08949404
23GATA1_19941826_ChIP-Seq_K562_Human2.07749903
24* E2F1_21310950_ChIP-Seq_MCF-7_Human2.07630173
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05606579
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04090824
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.03643586
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01316922
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.01208062
30E2F7_22180533_ChIP-Seq_HELA_Human11.4620392
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96851298
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.96157228
33GATA1_19941827_ChIP-Seq_MEL_Mouse1.89900098
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89821642
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.88293253
36GATA2_19941826_ChIP-Seq_K562_Human1.78884161
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77845593
38SPI1_23127762_ChIP-Seq_K562_Human1.76683393
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76364167
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73964803
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72847695
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.71703415
43ELK1_19687146_ChIP-ChIP_HELA_Human1.71207650
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70136696
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68313249
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.67659792
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64919074
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64387138
49GATA3_27048872_Chip-Seq_THYMUS_Human1.63604530
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.62420702
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59901599
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59896487
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58803379
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56375190
55* HNF4A_19822575_ChIP-Seq_HepG2_Human1.55262298
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55249627
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54096439
58* SPI1_23547873_ChIP-Seq_NB4_Human1.53846097
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52462309
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51009702
61VDR_23849224_ChIP-Seq_CD4+_Human1.48758812
62AR_21909140_ChIP-Seq_LNCAP_Human1.48570290
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48100863
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47951969
65FOXP3_21729870_ChIP-Seq_TREG_Human1.47696312
66VDR_24787735_ChIP-Seq_THP-1_Human1.46933696
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.46036998
68MYB_26560356_Chip-Seq_TH2_Human1.44151148
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43629490
70TCF7_22412390_ChIP-Seq_EML_Mouse1.38631122
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.38237376
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38041657
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.37153790
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36092043
75* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33775615
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.33753586
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33113585
78MAF_26560356_Chip-Seq_TH1_Human1.32184810
79* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31834808
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.30902498
81TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30004212
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28298834
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27973156
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27736644
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27537376
86MYB_26560356_Chip-Seq_TH1_Human1.27525303
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27419435
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25590237
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.24428583
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23252960
91CIITA_25753668_ChIP-Seq_RAJI_Human1.22490518
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22403928
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21975505
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19766437
95IRF1_19129219_ChIP-ChIP_H3396_Human1.18153772
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18088930
97EWS_26573619_Chip-Seq_HEK293_Human1.16626307
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15608585
99TP53_16413492_ChIP-PET_HCT116_Human1.15462027
100SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13909254
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13399686
102RUNX_20019798_ChIP-Seq_JUKART_Human1.12569687
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11478538
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11227504
105GATA3_26560356_Chip-Seq_TH2_Human1.10917178
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10847604
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10837876
108MYC_22102868_ChIP-Seq_BL_Human1.09965411
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.07638655
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07274490
111UTX_26944678_Chip-Seq_JUKART_Human1.06215025
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05739011
113CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05133934
114NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03293840
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.01728672
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01488597
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01393884
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00051764
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99120710
120GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98922731
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97434493
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97316498
123SRF_21415370_ChIP-Seq_HL-1_Mouse0.96692123
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96500010
125MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96020923
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95731588
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95292189
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93772533
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92888713
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92590299
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92211994
132BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90722777
133* GATA4_25053715_ChIP-Seq_YYC3_Human0.90666914
134EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90473604
135PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90255992
136MYC_18940864_ChIP-ChIP_HL60_Human0.89189196
137RUNX1_22412390_ChIP-Seq_EML_Mouse0.87952893
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87019125
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86180922
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86100928
141MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85810875
142SMAD_19615063_ChIP-ChIP_OVARY_Human0.85433035
143STAT3_18555785_Chip-Seq_ESCs_Mouse0.84921970
144CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83444872
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.83368731
146ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83038678
147* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81841521
148SALL1_21062744_ChIP-ChIP_HESCs_Human0.81781867
149MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81264695
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81201217
151SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79856245
152* GATA6_25053715_ChIP-Seq_YYC3_Human0.79825675
153VDR_24763502_ChIP-Seq_THP-1_Human0.79629584
154FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79159051
155VDR_21846776_ChIP-Seq_THP-1_Human0.78827010
156E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78034700
157PU_27001747_Chip-Seq_BMDM_Mouse0.77524082
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77300580
159TTF2_22483619_ChIP-Seq_HELA_Human0.76997059
160OCT4_18555785_Chip-Seq_ESCs_Mouse0.76764117
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76731883
162ZFX_18555785_Chip-Seq_ESCs_Mouse0.76321085
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75951183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.77490310
2MP0008260_abnormal_autophagy3.75109233
3MP0003656_abnormal_erythrocyte_physiolo3.63508106
4MP0010094_abnormal_chromosome_stability3.27831758
5MP0008057_abnormal_DNA_replication3.15252964
6MP0002139_abnormal_hepatobiliary_system3.10851195
7MP0005451_abnormal_body_composition2.97620057
8MP0003693_abnormal_embryo_hatching2.75745399
9MP0003172_abnormal_lysosome_physiology2.68224938
10MP0003111_abnormal_nucleus_morphology2.66829682
11MP0003195_calcinosis2.62489427
12MP0008058_abnormal_DNA_repair2.61460548
13MP0001835_abnormal_antigen_presentation2.55447669
14MP0003122_maternal_imprinting2.48839110
15MP0003763_abnormal_thymus_physiology2.39668296
16MP0005365_abnormal_bile_salt2.27567894
17MP0003077_abnormal_cell_cycle2.22714420
18MP0005085_abnormal_gallbladder_physiolo2.22081937
19MP0000490_abnormal_crypts_of2.22007108
20MP0005075_abnormal_melanosome_morpholog2.07157475
21MP0001188_hyperpigmentation2.07027591
22MP0003303_peritoneal_inflammation2.02454467
23MP0004808_abnormal_hematopoietic_stem2.02209227
24MP0005671_abnormal_response_to2.00602518
25MP0001666_abnormal_nutrient_absorption1.99521747
26MP0010329_abnormal_lipoprotein_level1.98946824
27MP0003252_abnormal_bile_duct1.93370858
28MP0005408_hypopigmentation1.86386079
29MP0004883_abnormal_blood_vessel1.85990030
30MP0000566_synostosis1.84218254
31MP0006292_abnormal_olfactory_placode1.82662061
32MP0001800_abnormal_humoral_immune1.81086260
33MP0005174_abnormal_tail_pigmentation1.79740017
34MP0008007_abnormal_cellular_replicative1.79325629
35MP0002398_abnormal_bone_marrow1.77555836
36MP0005360_urolithiasis1.76591700
37MP0009785_altered_susceptibility_to1.74301108
38MP0002166_altered_tumor_susceptibility1.71960310
39MP0000015_abnormal_ear_pigmentation1.71218253
40MP0002006_tumorigenesis1.70798027
41MP0001915_intracranial_hemorrhage1.69898803
42MP0003300_gastrointestinal_ulcer1.69769247
43MP0004957_abnormal_blastocyst_morpholog1.67301834
44MP0002452_abnormal_antigen_presenting1.65172131
45MP0002148_abnormal_hypersensitivity_rea1.64969065
46MP0002420_abnormal_adaptive_immunity1.64680226
47MP0001819_abnormal_immune_cell1.63733418
48MP0000569_abnormal_digit_pigmentation1.59042038
49MP0005387_immune_system_phenotype1.57875170
50MP0001790_abnormal_immune_system1.57875170
51MP0003787_abnormal_imprinting1.56782128
52MP0002723_abnormal_immune_serum1.55118086
53MP0002095_abnormal_skin_pigmentation1.51378213
54MP0003191_abnormal_cellular_cholesterol1.49825156
55MP0005000_abnormal_immune_tolerance1.48109137
56MP0003121_genomic_imprinting1.45796363
57MP0003868_abnormal_feces_composition1.45287297
58MP0000383_abnormal_hair_follicle1.45133184
59MP0005025_abnormal_response_to1.45125806
60MP0001545_abnormal_hematopoietic_system1.44518379
61MP0005397_hematopoietic_system_phenotyp1.44518379
62MP0000716_abnormal_immune_system1.43682381
63MP0002132_abnormal_respiratory_system1.43196328
64MP0005058_abnormal_lysosome_morphology1.43120784
65MP0009333_abnormal_splenocyte_physiolog1.42210972
66MP0000609_abnormal_liver_physiology1.40148767
67MP0002405_respiratory_system_inflammati1.40072950
68MP0008877_abnormal_DNA_methylation1.39015021
69MP0000703_abnormal_thymus_morphology1.38376493
70MP0002722_abnormal_immune_system1.37664172
71MP0002009_preneoplasia1.37400610
72MP0002419_abnormal_innate_immunity1.36071862
73MP0000685_abnormal_immune_system1.35889779
74MP0000689_abnormal_spleen_morphology1.35636776
75MP0006054_spinal_hemorrhage1.32159259
76MP0004381_abnormal_hair_follicle1.30713186
77MP0005164_abnormal_response_to1.29846447
78MP0002429_abnormal_blood_cell1.29076986
79MP0010155_abnormal_intestine_physiology1.28410323
80MP0003786_premature_aging1.27768508
81MP0002163_abnormal_gland_morphology1.26835662
82MP0010307_abnormal_tumor_latency1.24533426
83MP0002277_abnormal_respiratory_mucosa1.23785697
84MP0005076_abnormal_cell_differentiation1.19037130
85MP0003690_abnormal_glial_cell1.18894881
86MP0009697_abnormal_copulation1.18599224
87MP0003221_abnormal_cardiomyocyte_apopto1.18369557
88MP0003436_decreased_susceptibility_to1.17750261
89MP0000604_amyloidosis1.15039282
90MP0001873_stomach_inflammation1.13975754
91MP0002019_abnormal_tumor_incidence1.13260480
92MP0003941_abnormal_skin_development1.12180307
93MP0001851_eye_inflammation1.11194927
94MP0004782_abnormal_surfactant_physiolog1.11010790
95MP0008875_abnormal_xenobiotic_pharmacok1.09730600
96MP0002102_abnormal_ear_morphology1.09350207
97MP0000858_altered_metastatic_potential1.02274690
98MP0003724_increased_susceptibility_to1.01793739
99MP0001853_heart_inflammation1.01601829
100MP0008932_abnormal_embryonic_tissue0.99728105
101MP0000350_abnormal_cell_proliferation0.99404235
102MP0002118_abnormal_lipid_homeostasis0.97738378
103MP0000465_gastrointestinal_hemorrhage0.97544951
104MP0000598_abnormal_liver_morphology0.97496676
105MP0008469_abnormal_protein_level0.95895392
106MP0002938_white_spotting0.93869182
107MP0005464_abnormal_platelet_physiology0.92874842
108MP0008004_abnormal_stomach_pH0.92294581
109MP0001346_abnormal_lacrimal_gland0.92234939
110MP0000313_abnormal_cell_death0.90744121
111MP0004264_abnormal_extraembryonic_tissu0.90429256
112MP0003632_abnormal_nervous_system0.89912147
113MP0001119_abnormal_female_reproductive0.89673213
114MP0009763_increased_sensitivity_to0.88547253
115MP0002075_abnormal_coat/hair_pigmentati0.87292062
116MP0003123_paternal_imprinting0.87188487
117MP0001845_abnormal_inflammatory_respons0.87141600
118MP0003183_abnormal_peptide_metabolism0.86404008
119MP0003943_abnormal_hepatobiliary_system0.86012550
120MP0005376_homeostasis/metabolism_phenot0.85666459
121MP0003566_abnormal_cell_adhesion0.85202508
122MP0001186_pigmentation_phenotype0.85058584
123MP0009115_abnormal_fat_cell0.84415451
124MP0003828_pulmonary_edema0.83713226
125MP0002971_abnormal_brown_adipose0.82758786
126MP0004947_skin_inflammation0.81492480
127MP0004484_altered_response_of0.81468097
128MP0000372_irregular_coat_pigmentation0.81435583
129MP0010352_gastrointestinal_tract_polyps0.80475734
130MP0000427_abnormal_hair_cycle0.80331288
131MP0003091_abnormal_cell_migration0.79511371
132MP0005409_darkened_coat_color0.78676633
133MP0002138_abnormal_hepatobiliary_system0.78269240
134MP0004130_abnormal_muscle_cell0.77983243
135MP0000371_diluted_coat_color0.76545733
136MP0000249_abnormal_blood_vessel0.75787382
137MP0002998_abnormal_bone_remodeling0.75178009
138MP0001533_abnormal_skeleton_physiology0.73860723
139MP0003866_abnormal_defecation0.72737271
140MP0001293_anophthalmia0.72535467
141MP0002933_joint_inflammation0.70975337
142MP0005310_abnormal_salivary_gland0.70571685
143MP0008995_early_reproductive_senescence0.69760337
144MP0009278_abnormal_bone_marrow0.69257042
145MP0010678_abnormal_skin_adnexa0.68330898
146MP0003448_altered_tumor_morphology0.63982185
147MP0005171_absent_coat_pigmentation0.63288540

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.68502417
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.42451715
3Chromsome breakage (HP:0040012)5.39597288
4Gingival bleeding (HP:0000225)5.19465703
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.71980272
6Abnormality of the common coagulation pathway (HP:0010990)4.66043596
7Prolonged partial thromboplastin time (HP:0003645)4.61909560
8Acanthocytosis (HP:0001927)4.34931442
9Hypobetalipoproteinemia (HP:0003563)4.34246074
10Recurrent gram-negative bacterial infections (HP:0005420)4.09278812
11Complement deficiency (HP:0004431)4.06066354
12Menorrhagia (HP:0000132)4.05754598
13Poikilocytosis (HP:0004447)3.93760127
14Joint hemorrhage (HP:0005261)3.90975659
15Gastrointestinal infarctions (HP:0005244)3.81439731
16Prolonged bleeding time (HP:0003010)3.81409935
17Epistaxis (HP:0000421)3.66122042
18Spontaneous abortion (HP:0005268)3.59747050
19Peritonitis (HP:0002586)3.28183450
20Abnormality of chromosome stability (HP:0003220)3.20574945
21Abnormality of the preputium (HP:0100587)3.15160519
22Abnormality of complement system (HP:0005339)3.10275725
23Birth length less than 3rd percentile (HP:0003561)3.05915147
24Meckel diverticulum (HP:0002245)3.05556139
25Papillary thyroid carcinoma (HP:0002895)3.03587581
26Aplasia/Hypoplasia of the uvula (HP:0010293)3.02866381
27Purpura (HP:0000979)2.96689197
28Glomerulonephritis (HP:0000099)2.91025347
29Thrombophlebitis (HP:0004418)2.88805806
30Abnormality of the ileum (HP:0001549)2.88079365
31IgM deficiency (HP:0002850)2.88033565
32Increased mean platelet volume (HP:0011877)2.86543796
33Abnormal platelet volume (HP:0011876)2.86499581
34Abnormality of the fingertips (HP:0001211)2.83815315
35Myositis (HP:0100614)2.83425651
36Clubbing of toes (HP:0100760)2.80367436
37Arterial thrombosis (HP:0004420)2.75610491
38Ectopic kidney (HP:0000086)2.72815954
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.70740753
40Orthostatic hypotension (HP:0001278)2.64886402
41Subacute progressive viral hepatitis (HP:0006572)2.63015178
42Abnormality of the prostate (HP:0008775)2.62653776
43Flat acetabular roof (HP:0003180)2.62392411
44Spontaneous hematomas (HP:0007420)2.61962677
45Myocardial infarction (HP:0001658)2.58743909
46Myelodysplasia (HP:0002863)2.57665597
47Systemic lupus erythematosus (HP:0002725)2.57311296
48Abnormality of the peritoneum (HP:0002585)2.57228748
49Acute hepatic failure (HP:0006554)2.54382903
50Retrobulbar optic neuritis (HP:0100654)2.52146217
51Optic neuritis (HP:0100653)2.52146217
52B lymphocytopenia (HP:0010976)2.51923728
53Abnormality of B cell number (HP:0010975)2.51923728
54Pulmonary embolism (HP:0002204)2.51893640
55Prostate neoplasm (HP:0100787)2.51280592
56Slow saccadic eye movements (HP:0000514)2.50693602
57Gingivitis (HP:0000230)2.50412552
58Xanthomatosis (HP:0000991)2.49386804
59Acute myeloid leukemia (HP:0004808)2.48582727
60Hypochromic microcytic anemia (HP:0004840)2.47356423
61Type I transferrin isoform profile (HP:0003642)2.46891853
62Recurrent skin infections (HP:0001581)2.46163413
63Hypolipoproteinemia (HP:0010981)2.41094971
64Recurrent viral infections (HP:0004429)2.39726187
65Reticulocytopenia (HP:0001896)2.39704330
66Reduced antithrombin III activity (HP:0001976)2.38155270
67Bone marrow hypocellularity (HP:0005528)2.36929547
68Duodenal stenosis (HP:0100867)2.34097346
69Small intestinal stenosis (HP:0012848)2.34097346
70Hemorrhage of the eye (HP:0011885)2.33347186
71Abnormality of the carotid arteries (HP:0005344)2.33226951
72Hypochromic anemia (HP:0001931)2.30941920
73Aplastic anemia (HP:0001915)2.29528896
74Recurrent fungal infections (HP:0002841)2.28088173
75Thrombocytosis (HP:0001894)2.26168647
76Thyroiditis (HP:0100646)2.25768126
77Volvulus (HP:0002580)2.25347954
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.24106801
79Recurrent abscess formation (HP:0002722)2.23929901
8011 pairs of ribs (HP:0000878)2.23602729
81Orchitis (HP:0100796)2.23291594
82Hypercholesterolemia (HP:0003124)2.22328451
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21457015
84IgG deficiency (HP:0004315)2.20635567
85Conjunctival telangiectasia (HP:0000524)2.20014973
86Eosinophilia (HP:0001880)2.19986598
87Nephroblastoma (Wilms tumor) (HP:0002667)2.18036835
88Abnormality of the columella (HP:0009929)2.16756306
89Abnormality of macrophages (HP:0004311)2.16397859
90Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16185307
91Abnormality of DNA repair (HP:0003254)2.15670136
92Duplicated collecting system (HP:0000081)2.15111480
93Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14695899
94Joint swelling (HP:0001386)2.14299909
95Panhypogammaglobulinemia (HP:0003139)2.14185798
96Vasculitis (HP:0002633)2.14116447
97Diastasis recti (HP:0001540)2.13954348
98Meningitis (HP:0001287)2.12758370
99Petechiae (HP:0000967)2.12708176
100Mitral stenosis (HP:0001718)2.12091651
101Abnormal foot bone ossification (HP:0010675)2.11638667
102Hepatocellular carcinoma (HP:0001402)2.11358872
103Arthropathy (HP:0003040)2.07059291
104Abnormality of the lumbar spine (HP:0100712)2.05641966
105Granulocytopenia (HP:0001913)2.05456938
106Abnormality of the incisor (HP:0000676)2.05198793
107Abnormality of the renal collecting system (HP:0004742)2.04445879
108Broad palm (HP:0001169)2.03719625
109Abnormal tarsal ossification (HP:0008369)2.03539831
110Viral hepatitis (HP:0006562)2.02839850
111Lymphoma (HP:0002665)2.02226456
112Embryonal renal neoplasm (HP:0011794)2.01837989
113Broad alveolar ridges (HP:0000187)2.00912869
114Conjugated hyperbilirubinemia (HP:0002908)2.00500101
115Recurrent bacterial skin infections (HP:0005406)1.99474255
116Elevated erythrocyte sedimentation rate (HP:0003565)1.98277666
117Abnormality of T cell physiology (HP:0011840)1.98116537
118Hyperlipoproteinemia (HP:0010980)1.96058631
119Osteomalacia (HP:0002749)1.95525446
120Severe combined immunodeficiency (HP:0004430)1.95346601
121Polycythemia (HP:0001901)1.95210281
122Mediastinal lymphadenopathy (HP:0100721)1.95206656
123Postural instability (HP:0002172)1.94912148
124Gangrene (HP:0100758)1.94565491
125Abnormality of T cells (HP:0002843)1.93903417
126Abnormality of T cell number (HP:0011839)1.93400057
127Recurrent cutaneous fungal infections (HP:0011370)1.93311214
128Chronic mucocutaneous candidiasis (HP:0002728)1.93311214
129Abnormality of the nasal septum (HP:0000419)1.93182256
130IgA deficiency (HP:0002720)1.92620169
131Episodic fever (HP:0001954)1.91901366
132Visual hallucinations (HP:0002367)1.91542794
133Chronic diarrhea (HP:0002028)1.91172823
134Deep philtrum (HP:0002002)1.89775684
135Recurrent pneumonia (HP:0006532)1.89698402
136Abnormality of incisor morphology (HP:0011063)1.89188125
137Agammaglobulinemia (HP:0004432)1.89086181
138Asymmetry of the thorax (HP:0001555)1.87258167
139Sloping forehead (HP:0000340)1.87111819
140Keratoconjunctivitis sicca (HP:0001097)1.86328384
141Mesomelia (HP:0003027)1.86241277
142Hypoplasia of the thymus (HP:0000778)1.86101411
143Amyloidosis (HP:0011034)1.86000022
144Lymphopenia (HP:0001888)1.85881806
145Abnormality of eosinophils (HP:0001879)1.85767115
146Syringomyelia (HP:0003396)1.85510943
147Spinal cord lesions (HP:0100561)1.85510943
148Microcytic anemia (HP:0001935)1.85299702
149Dislocated radial head (HP:0003083)1.84723139
150Toxemia of pregnancy (HP:0100603)1.84563867
151Combined immunodeficiency (HP:0005387)1.84401666
152Abnormality of cells of the lymphoid lineage (HP:0012140)1.84304991
153Periodontitis (HP:0000704)1.82298507
154Acute lymphatic leukemia (HP:0006721)1.81516663
155Leukopenia (HP:0001882)1.81335603
156T lymphocytopenia (HP:0005403)1.80797701
157Nephritis (HP:0000123)1.80691906
158Chest pain (HP:0100749)1.80320659
159Small epiphyses (HP:0010585)1.79944700
160Coarse hair (HP:0002208)1.79854066
161Leukocytosis (HP:0001974)1.79463952
162Impaired platelet aggregation (HP:0003540)1.79422777
163Abnormal platelet function (HP:0011869)1.79422777
164Obstructive lung disease (HP:0006536)1.78578294
165Chronic obstructive pulmonary disease (HP:0006510)1.78578294
166Encephalitis (HP:0002383)1.77949615
167Abnormal hair whorl (HP:0010721)1.77276623
168Autoimmune thrombocytopenia (HP:0001973)1.76501439
169Tubulointerstitial nephritis (HP:0001970)1.75382328
170Selective tooth agenesis (HP:0001592)1.74380845
171Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74141828
172Abnormal protein N-linked glycosylation (HP:0012347)1.74141828
173Abnormal protein glycosylation (HP:0012346)1.74141828
174Abnormal glycosylation (HP:0012345)1.74141828
175Abnormal number of incisors (HP:0011064)1.73664879
176Abnormality of the duodenum (HP:0002246)1.72902400
177Absent frontal sinuses (HP:0002688)1.71758330
178Optic nerve coloboma (HP:0000588)1.71644168
179Keratoconjunctivitis (HP:0001096)1.71264369
180Abnormal lung lobation (HP:0002101)1.68776286
181Eczematoid dermatitis (HP:0000976)1.67715686
182Recurrent lower respiratory tract infections (HP:0002783)1.65872605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR43.32008672
2RIPK43.01394367
3TXK2.93043276
4CDC72.72023807
5FGR2.70506697
6ZAK2.52799447
7EIF2AK22.35591965
8MAP3K142.34188846
9IRAK42.29749445
10SRPK12.23191755
11CDK122.10817402
12WNK12.02328955
13PLK41.98585214
14NUAK11.85680307
15MAP3K21.77320918
16CSK1.75382579
17KIT1.74919526
18ACVR1B1.73031343
19TEC1.71820874
20MAP4K11.70288981
21NEK21.68410940
22IRAK31.64694029
23ATR1.63981988
24CLK11.57129879
25JAK31.52232789
26TTK1.49617953
27MKNK21.48330977
28PIK3CG1.48054785
29CSF1R1.47595147
30BTK1.40880487
31MKNK11.40690325
32STK41.39665565
33SIK31.39488599
34VRK11.38130936
35BRD41.37961178
36GRK51.36550970
37RPS6KA41.36052476
38ICK1.36046364
39PRPF4B1.33681779
40SGK4941.33301416
41SGK2231.33301416
42PIM11.33030586
43YES11.31684734
44CDK71.29400663
45IKBKB1.29167962
46IKBKE1.27766081
47STK161.26083886
48BRSK21.24798034
49EIF2AK31.23639162
50WEE11.23161515
51GRK11.22872905
52PTK2B1.21527128
53ERBB21.19838122
54MAP3K31.19415238
55CHUK1.17717738
56FES1.17426349
57MST41.16568123
58STK101.15215150
59RPS6KB21.14282753
60PIM21.12889843
61MAP3K11.12650055
62PLK11.11684687
63BMPR21.10960490
64AURKB1.08878208
65CHEK21.07468359
66CDK81.06170574
67TGFBR21.05643608
68FRK1.05071508
69TAOK31.04773464
70CCNB11.03918173
71ZAP701.02577205
72JAK20.99619983
73BMPR1B0.98335168
74RET0.98312648
75SGK20.97159272
76CAMKK20.96928774
77FGFR20.96334231
78PDK10.96256391
79PIK3CA0.96118930
80MAP3K100.96010795
81CAMK1D0.95595713
82FGFR30.95572833
83ERN10.95541389
84TYK20.93566131
85TRPM70.93422594
86MARK20.92660635
87EIF2AK10.92303873
88STK30.91354655
89SYK0.90758206
90TLK10.90628911
91ADRBK20.90263328
92PRKAA20.90097475
93TNIK0.86374307
94JAK10.84619763
95AKT30.84547703
96CDK60.84202110
97TYRO30.83780667
98PLK20.83390264
99CDK40.83047337
100KSR20.82893019
101MAP3K50.82506990
102NEK90.81624536
103LYN0.81501419
104SGK10.81319300
105RIPK10.80755967
106ITK0.78857704
107PDPK10.78572190
108IRAK10.77431363
109TAOK10.76762461
110MELK0.76482680
111BLK0.76176839
112CHEK10.75980129
113ATM0.75426496
114MAPK110.73226531
115PLK30.71735453
116MAP3K130.71329603
117MAP3K60.70294072
118LCK0.69557180
119MARK30.69136309
120MAP2K30.68635716
121BUB10.67823432
122TBK10.66891735
123CAMK1G0.66766751
124NLK0.66122641
125TAOK20.65500760
126RPS6KB10.64941989
127DYRK30.64585988
128DYRK1A0.64298166
129CASK0.62325433
130LATS10.60986540
131TRIB30.59922953
132MAP3K70.58560927
133STK240.57610814
134PDGFRA0.57440533
135FLT30.57408734
136DYRK1B0.56978965
137MAP3K110.56406863
138NME20.55679289
139LRRK20.55624890
140EPHA30.54965461
141GRK60.52963777
142PKN20.52635205
143RPS6KA50.52621698
144FGFR10.52242068
145ERBB30.51499357
146TSSK60.51327304
147PDGFRB0.51283545
148TNK20.51214384
149PASK0.49206778
150HCK0.48116775
151MATK0.47604928
152MAP2K60.47496990
153SGK30.47456617
154RPS6KA60.47401006
155STK380.47221179
156CAMK40.46918932
157PTK60.44744452
158TGFBR10.43956363
159IRAK20.43441812

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.43584871
2DNA replication_Homo sapiens_hsa030303.77082588
3Homologous recombination_Homo sapiens_hsa034403.06469311
4Staphylococcus aureus infection_Homo sapiens_hsa051503.05400831
5Mismatch repair_Homo sapiens_hsa034302.93771593
6Fanconi anemia pathway_Homo sapiens_hsa034602.77870303
7Base excision repair_Homo sapiens_hsa034102.75703331
8Non-homologous end-joining_Homo sapiens_hsa034502.25441103
9Primary immunodeficiency_Homo sapiens_hsa053402.18335711
10Cell cycle_Homo sapiens_hsa041102.17304651
11Nucleotide excision repair_Homo sapiens_hsa034201.97374016
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97268409
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96690576
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.85558670
15One carbon pool by folate_Homo sapiens_hsa006701.79683399
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.76711822
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.72192033
18Herpes simplex infection_Homo sapiens_hsa051681.71118264
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68071561
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67658760
21Measles_Homo sapiens_hsa051621.65747806
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64984490
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.58269768
24Fatty acid biosynthesis_Homo sapiens_hsa000611.54449688
25RNA degradation_Homo sapiens_hsa030181.53421800
26Hematopoietic cell lineage_Homo sapiens_hsa046401.52806705
27Spliceosome_Homo sapiens_hsa030401.51147481
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48003777
29p53 signaling pathway_Homo sapiens_hsa041151.44758490
30Allograft rejection_Homo sapiens_hsa053301.44043003
31Pyrimidine metabolism_Homo sapiens_hsa002401.42867961
32Basal transcription factors_Homo sapiens_hsa030221.42440015
33Leishmaniasis_Homo sapiens_hsa051401.37632030
34Ribosome_Homo sapiens_hsa030101.35376405
35RNA transport_Homo sapiens_hsa030131.33881936
36RNA polymerase_Homo sapiens_hsa030201.28853759
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27236705
38Fat digestion and absorption_Homo sapiens_hsa049751.26181719
39Graft-versus-host disease_Homo sapiens_hsa053321.24517628
40Starch and sucrose metabolism_Homo sapiens_hsa005001.24309833
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21839941
42PPAR signaling pathway_Homo sapiens_hsa033201.21753941
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19172899
44Fatty acid degradation_Homo sapiens_hsa000711.16426795
45FoxO signaling pathway_Homo sapiens_hsa040681.15226628
46Autoimmune thyroid disease_Homo sapiens_hsa053201.12574865
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.12210465
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11912769
49Endometrial cancer_Homo sapiens_hsa052131.11645718
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11321192
51Influenza A_Homo sapiens_hsa051641.10921794
52mRNA surveillance pathway_Homo sapiens_hsa030151.10451243
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10435001
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08457840
55Prolactin signaling pathway_Homo sapiens_hsa049171.08168975
56ABC transporters_Homo sapiens_hsa020101.08109254
57Antigen processing and presentation_Homo sapiens_hsa046121.07714737
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.07468175
59Retinol metabolism_Homo sapiens_hsa008301.06925140
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05856860
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.04012073
62Systemic lupus erythematosus_Homo sapiens_hsa053221.03800976
63Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03115882
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02956262
65Renin-angiotensin system_Homo sapiens_hsa046141.02383939
66Legionellosis_Homo sapiens_hsa051341.02115313
67Small cell lung cancer_Homo sapiens_hsa052221.01308964
68Hepatitis B_Homo sapiens_hsa051611.01017084
69Vitamin digestion and absorption_Homo sapiens_hsa049771.00350578
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.98545192
71Insulin resistance_Homo sapiens_hsa049310.96196378
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95484900
73Viral carcinogenesis_Homo sapiens_hsa052030.95079238
74Histidine metabolism_Homo sapiens_hsa003400.94896768
75HTLV-I infection_Homo sapiens_hsa051660.94363492
76Asthma_Homo sapiens_hsa053100.94133650
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91462746
78Arginine biosynthesis_Homo sapiens_hsa002200.90275861
79Epstein-Barr virus infection_Homo sapiens_hsa051690.89538006
80Chemical carcinogenesis_Homo sapiens_hsa052040.87763496
81mTOR signaling pathway_Homo sapiens_hsa041500.85760748
82Apoptosis_Homo sapiens_hsa042100.85735146
83B cell receptor signaling pathway_Homo sapiens_hsa046620.85299512
84Osteoclast differentiation_Homo sapiens_hsa043800.84064563
85Purine metabolism_Homo sapiens_hsa002300.82577078
86Bile secretion_Homo sapiens_hsa049760.81191145
87MicroRNAs in cancer_Homo sapiens_hsa052060.80048211
88Renal cell carcinoma_Homo sapiens_hsa052110.79506534
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79348851
90TNF signaling pathway_Homo sapiens_hsa046680.78576714
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75024531
92Toxoplasmosis_Homo sapiens_hsa051450.74740450
93Malaria_Homo sapiens_hsa051440.74418360
94Arachidonic acid metabolism_Homo sapiens_hsa005900.73887494
95T cell receptor signaling pathway_Homo sapiens_hsa046600.73304055
96Choline metabolism in cancer_Homo sapiens_hsa052310.72508965
97Dorso-ventral axis formation_Homo sapiens_hsa043200.72142824
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72123953
99HIF-1 signaling pathway_Homo sapiens_hsa040660.71911558
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71311327
101Proteasome_Homo sapiens_hsa030500.69580124
102N-Glycan biosynthesis_Homo sapiens_hsa005100.69376475
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68890284
104Acute myeloid leukemia_Homo sapiens_hsa052210.66342967
105VEGF signaling pathway_Homo sapiens_hsa043700.66338516
106Lysine degradation_Homo sapiens_hsa003100.65567025
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.65051650
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.64248056
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62957475
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62520456
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61764351
112Pancreatic cancer_Homo sapiens_hsa052120.61502571
113Chronic myeloid leukemia_Homo sapiens_hsa052200.61259670
114Hepatitis C_Homo sapiens_hsa051600.60947630
115Glioma_Homo sapiens_hsa052140.60733127
116Viral myocarditis_Homo sapiens_hsa054160.60028281
117Protein export_Homo sapiens_hsa030600.59955643
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59908634
119Shigellosis_Homo sapiens_hsa051310.59830935
120Phenylalanine metabolism_Homo sapiens_hsa003600.59345359
121Type I diabetes mellitus_Homo sapiens_hsa049400.57550676
122Tuberculosis_Homo sapiens_hsa051520.55972239
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54902990
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54222829
125Fatty acid metabolism_Homo sapiens_hsa012120.54053653
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.52548024
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52498209
128Pathways in cancer_Homo sapiens_hsa052000.51188343
129African trypanosomiasis_Homo sapiens_hsa051430.50805993
130Prostate cancer_Homo sapiens_hsa052150.50574610
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.50060492
132Chemokine signaling pathway_Homo sapiens_hsa040620.49968827
133Thyroid cancer_Homo sapiens_hsa052160.49475241
134Caffeine metabolism_Homo sapiens_hsa002320.49208578
135Glycerolipid metabolism_Homo sapiens_hsa005610.47998454
136Other glycan degradation_Homo sapiens_hsa005110.46387401
137AMPK signaling pathway_Homo sapiens_hsa041520.45878603
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44085685
139Pertussis_Homo sapiens_hsa051330.43952393
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43443157
141Basal cell carcinoma_Homo sapiens_hsa052170.42336806
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39127729
143Non-small cell lung cancer_Homo sapiens_hsa052230.37374961
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36062592
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36060900
146Salmonella infection_Homo sapiens_hsa051320.35589080
147Platelet activation_Homo sapiens_hsa046110.35100670
148Adherens junction_Homo sapiens_hsa045200.34438174
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32051674
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31584151
151Colorectal cancer_Homo sapiens_hsa052100.31475189
152Inositol phosphate metabolism_Homo sapiens_hsa005620.31441651
153Notch signaling pathway_Homo sapiens_hsa043300.31026419

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