MBOAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the membrane-bound O-acetyltransferase superfamily. The encoded transmembrane protein is an enzyme that transfers organic compounds, preferably from oleoyl-CoA, to hydroxyl groups of protein targets in membranes. A translocation disrupting this gene may be associated with brachydactyly syndactyly syndrome. Alternately spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.75482062
2hepatocyte apoptotic process (GO:0097284)5.93829991
3intestinal epithelial cell development (GO:0060576)5.65223493
4positive regulation of gamma-delta T cell activation (GO:0046645)5.54460009
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.13925874
6positive regulation by symbiont of host defense response (GO:0052509)5.09353057
7modulation by symbiont of host defense response (GO:0052031)5.09353057
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.09353057
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.09353057
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.09353057
11modulation by symbiont of host immune response (GO:0052553)5.09353057
12UDP-N-acetylglucosamine metabolic process (GO:0006047)4.94617433
13desmosome organization (GO:0002934)4.87622583
14maintenance of gastrointestinal epithelium (GO:0030277)4.86307794
15mesodermal cell differentiation (GO:0048333)4.85092786
16bundle of His cell to Purkinje myocyte communication (GO:0086069)4.79825970
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.79608549
18negative regulation of cell killing (GO:0031342)4.79608549
19antigen processing and presentation of endogenous antigen (GO:0019883)4.70404096
20detection of other organism (GO:0098543)4.63929550
21response to peptidoglycan (GO:0032494)4.54074778
22fucose catabolic process (GO:0019317)4.52998901
23L-fucose metabolic process (GO:0042354)4.52998901
24L-fucose catabolic process (GO:0042355)4.52998901
25interferon-gamma secretion (GO:0072643)4.47916354
26negative regulation of T cell differentiation in thymus (GO:0033085)4.36822596
27neutrophil activation involved in immune response (GO:0002283)4.33460560
28detection of bacterium (GO:0016045)4.29148899
29calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.24492639
30regulation of B cell receptor signaling pathway (GO:0050855)4.18583726
31O-glycan processing (GO:0016266)4.17024518
32macrophage activation involved in immune response (GO:0002281)4.15595314
33regulation of gamma-delta T cell activation (GO:0046643)4.13091468
34regulation of chemokine secretion (GO:0090196)4.12620499
35detection of molecule of bacterial origin (GO:0032490)4.11760200
36regulation of interferon-beta biosynthetic process (GO:0045357)3.99630341
37branching involved in prostate gland morphogenesis (GO:0060442)3.99568404
38keratinocyte proliferation (GO:0043616)3.98909970
39detection of external biotic stimulus (GO:0098581)3.98271182
40cellular extravasation (GO:0045123)3.94507717
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.92921895
42negative regulation of erythrocyte differentiation (GO:0045647)3.87063008
43tight junction assembly (GO:0070830)3.76409012
44regulation of gamma-delta T cell differentiation (GO:0045586)3.75843772
45axon ensheathment in central nervous system (GO:0032291)3.70984801
46central nervous system myelination (GO:0022010)3.70984801
47hypotonic response (GO:0006971)3.68550614
48response to muramyl dipeptide (GO:0032495)3.59002448
49immunoglobulin mediated immune response (GO:0016064)3.54927838
50antibacterial humoral response (GO:0019731)3.54428191
51positive regulation of actin filament depolymerization (GO:0030836)3.54330586
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.51463670
53response to host immune response (GO:0052572)3.51463670
54negative regulation of interleukin-12 production (GO:0032695)3.50432028
55positive regulation of pseudopodium assembly (GO:0031274)3.49990504
56cell differentiation involved in embryonic placenta development (GO:0060706)3.49179302
57detection of biotic stimulus (GO:0009595)3.49151861
58positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.46350242
59B cell receptor signaling pathway (GO:0050853)3.43291190
60nucleotide-sugar biosynthetic process (GO:0009226)3.39996408
61myelin maintenance (GO:0043217)3.39032257
62epithelial structure maintenance (GO:0010669)3.38612116
63leukocyte aggregation (GO:0070486)3.38115063
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37991197
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37691204
66response to host (GO:0075136)3.37691204
67response to host defenses (GO:0052200)3.37691204
68respiratory burst (GO:0045730)3.37356885
69negative regulation of lymphocyte mediated immunity (GO:0002707)3.37190781
70skin morphogenesis (GO:0043589)3.36988334
71fucose metabolic process (GO:0006004)3.36382646
72antimicrobial humoral response (GO:0019730)3.35371166
73antigen processing and presentation via MHC class Ib (GO:0002475)3.27163266
74neutrophil activation (GO:0042119)3.25294794
75positive regulation of B cell differentiation (GO:0045579)3.20829654
76cyclooxygenase pathway (GO:0019371)3.20422879
77extracellular matrix assembly (GO:0085029)3.18392319
78cell adhesion mediated by integrin (GO:0033627)3.16548145
79membrane raft organization (GO:0031579)3.15894597
80epithelial cell-cell adhesion (GO:0090136)3.13467511
81regulation of pseudopodium assembly (GO:0031272)3.12614209
82regulation of mast cell degranulation (GO:0043304)3.12387796
83microglial cell activation (GO:0001774)3.12254421
84negative thymic T cell selection (GO:0045060)3.11991771
85positive regulation of interferon-alpha production (GO:0032727)3.07859930
86germinal center formation (GO:0002467)3.05022116
87regulation of leukocyte degranulation (GO:0043300)3.04626825
88macrophage activation (GO:0042116)3.04427141
89regulation of transforming growth factor beta1 production (GO:0032908)3.03916847
90negative regulation of T cell mediated immunity (GO:0002710)3.03765334
91amyloid precursor protein metabolic process (GO:0042982)3.03566473
92myeloid cell activation involved in immune response (GO:0002275)3.01902720
93positive thymic T cell selection (GO:0045059)3.01572203
94regulation of respiratory burst (GO:0060263)3.00749773
95diol metabolic process (GO:0034311)3.00664066
96negative regulation of leukocyte mediated immunity (GO:0002704)3.00031049
97granulocyte activation (GO:0036230)2.98688557
98positive regulation of cellular amide metabolic process (GO:0034250)2.98576613
99regulation of water loss via skin (GO:0033561)2.96473146
100negative T cell selection (GO:0043383)2.96319868
101protein autoprocessing (GO:0016540)2.94460706
102regulation of myeloid leukocyte mediated immunity (GO:0002886)2.92468040
103positive regulation of tolerance induction (GO:0002645)2.92113723
104response to type I interferon (GO:0034340)2.91191311
105cellular response to type I interferon (GO:0071357)2.90942582
106type I interferon signaling pathway (GO:0060337)2.90942582
107B cell mediated immunity (GO:0019724)2.89399657
108antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88982634
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88982634
110histone H3-K36 demethylation (GO:0070544)2.87227434
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86902724
112production of molecular mediator involved in inflammatory response (GO:0002532)2.86384649
113sphingoid metabolic process (GO:0046519)2.85508575
114regulation of B cell differentiation (GO:0045577)2.85258745
115purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.84680589
1163-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.84680589
117lung lobe morphogenesis (GO:0060463)2.84337909
118lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84048511
119regulation of metalloenzyme activity (GO:0048552)2.83892167
120lung secretory cell differentiation (GO:0061140)2.82860101
121tolerance induction (GO:0002507)2.82451949
122embryonic process involved in female pregnancy (GO:0060136)2.81642067
123regulation of tolerance induction (GO:0002643)2.81358988
124regulation of interferon-alpha production (GO:0032647)2.81276833
125regulation of mast cell activation involved in immune response (GO:0033006)2.80095073
126positive regulation of Cdc42 GTPase activity (GO:0043089)2.79660452
127response to interleukin-15 (GO:0070672)2.74509005
128positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.74091787
129negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74036473
130T cell migration (GO:0072678)2.73432226
131neutrophil mediated immunity (GO:0002446)2.72008088
132T cell selection (GO:0045058)2.69851501
133positive regulation of osteoblast proliferation (GO:0033690)2.69848669
134regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69101559
135regulation of T-helper 2 cell differentiation (GO:0045628)2.67381304
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67371150
137regulation of necroptotic process (GO:0060544)2.66456881
138interferon-gamma-mediated signaling pathway (GO:0060333)2.66068263
139isoprenoid biosynthetic process (GO:0008299)2.65037235
140regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.63633098
141cell-cell junction assembly (GO:0007043)2.63460724
142negative regulation of keratinocyte proliferation (GO:0010839)2.62899381
143leukocyte migration involved in inflammatory response (GO:0002523)2.62139258
144thymic T cell selection (GO:0045061)2.62051454
145positive regulation of protein localization to plasma membrane (GO:1903078)2.61035621
146positive regulation of interleukin-8 secretion (GO:2000484)2.59984603
147keratinocyte differentiation (GO:0030216)2.59428642
148regulation of interleukin-8 secretion (GO:2000482)2.58618104
149ribosomal large subunit biogenesis (GO:0042273)2.58244664
150defense response to protozoan (GO:0042832)2.57254704
151regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56567412
152membrane budding (GO:0006900)2.56561118
153megakaryocyte development (GO:0035855)2.56505473
154epidermal cell differentiation (GO:0009913)2.55973307
155hepatocyte differentiation (GO:0070365)2.55786990
156positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.54905435
157positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.54754162
158positive regulation of mast cell activation (GO:0033005)2.54723333
159protein O-linked glycosylation (GO:0006493)2.53853490
160NIK/NF-kappaB signaling (GO:0038061)2.53074870
161protein neddylation (GO:0045116)2.53062808
162negative regulation of interleukin-6 production (GO:0032715)2.53060858
163ribosomal small subunit biogenesis (GO:0042274)2.52348982
164regulation of alpha-beta T cell proliferation (GO:0046640)2.52265443
165JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52007462
166positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51100479
167negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50905440
168establishment of epithelial cell polarity (GO:0090162)2.50818037
169viral transcription (GO:0019083)2.48272289
170epithelial cell differentiation involved in prostate gland development (GO:0060742)2.48270456
171positive regulation of epidermal cell differentiation (GO:0045606)2.46991401
172renal filtration (GO:0097205)2.46094802
173mucosal immune response (GO:0002385)2.45602939
174chondrocyte proliferation (GO:0035988)2.45310665
175peptide cross-linking (GO:0018149)2.45209887
176actin filament depolymerization (GO:0030042)2.45025068
177lung-associated mesenchyme development (GO:0060484)2.44658437
178prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.43409140
179purine ribonucleotide transport (GO:0015868)2.40331770
180pyrimidine-containing compound transmembrane transport (GO:0072531)2.39615567
181endothelial cell morphogenesis (GO:0001886)2.39235443
182establishment of endothelial barrier (GO:0061028)2.38057938
183localization within membrane (GO:0051668)2.36399052
184epithelial cell maturation (GO:0002070)2.36232284
185SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.35980397
186translational termination (GO:0006415)2.35495797
187protein targeting to ER (GO:0045047)2.34614412
188nucleotide-sugar metabolic process (GO:0009225)2.34462419
189negative regulation of interleukin-8 production (GO:0032717)2.33506011
190cotranslational protein targeting to membrane (GO:0006613)2.32975934
191cholesterol biosynthetic process (GO:0006695)2.32153440
192sphingosine metabolic process (GO:0006670)2.31473831
193regulation of podosome assembly (GO:0071801)2.31433344
194fucosylation (GO:0036065)2.30898901
195* phosphatidylserine metabolic process (GO:0006658)2.30872281
196columnar/cuboidal epithelial cell development (GO:0002066)2.30154395
197regulation of viral release from host cell (GO:1902186)2.29695145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.92813697
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.12289375
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.69206119
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.36138849
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18612195
6* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.17470097
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.97115723
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.95480801
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.93974946
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93650629
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.92341207
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91192596
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.85776301
14GATA4_25053715_ChIP-Seq_YYC3_Human2.68317127
15SOX2_20726797_ChIP-Seq_SW620_Human2.67726859
16MYC_22102868_ChIP-Seq_BL_Human2.64649601
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.62598038
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.62593306
19* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.56722124
20* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.56722124
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.48650519
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47783649
23AR_21909140_ChIP-Seq_LNCAP_Human2.47070261
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.45858716
25SCL_19346495_ChIP-Seq_HPC-7_Human2.38211579
26MAF_26560356_Chip-Seq_TH1_Human2.25824922
27GATA6_25053715_ChIP-Seq_YYC3_Human2.19511826
28TCF7_22412390_ChIP-Seq_EML_Mouse2.18375783
29SPI1_23127762_ChIP-Seq_K562_Human2.15139898
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14795435
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12947083
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.12867185
33* ESR2_21235772_ChIP-Seq_MCF-7_Human2.12250045
34ESR1_21235772_ChIP-Seq_MCF-7_Human2.11780379
35PPAR_26484153_Chip-Seq_NCI-H1993_Human2.08072831
36ZNF263_19887448_ChIP-Seq_K562_Human2.07443182
37GATA1_22025678_ChIP-Seq_K562_Human2.05908457
38ESR1_20079471_ChIP-ChIP_T-47D_Human2.01534282
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01292253
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.00033037
41MYB_26560356_Chip-Seq_TH1_Human1.99228726
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96574313
43RUNX_20019798_ChIP-Seq_JUKART_Human1.95771763
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.95102753
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93387585
46E2F7_22180533_ChIP-Seq_HELA_Human1.93106513
47UTX_26944678_Chip-Seq_JUKART_Human1.87526828
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85851218
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.83916625
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83639374
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82616172
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.75950842
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73669867
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.71972596
55* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.62987876
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.61471822
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61279392
58* KLF5_25053715_ChIP-Seq_YYC3_Human1.61099173
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60912030
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57451270
61KDM2B_26808549_Chip-Seq_DND41_Human1.56795611
62GATA3_24758297_ChIP-Seq_MCF-7_Human1.56734905
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56339348
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54724151
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.54533136
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.53500731
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49182948
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48414767
69ATF3_27146783_Chip-Seq_COLON_Human1.47708829
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46752235
71MAF_26560356_Chip-Seq_TH2_Human1.46367419
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.46067167
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45807600
74RACK7_27058665_Chip-Seq_MCF-7_Human1.45619919
75EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.45325657
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.44019589
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43095304
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42173800
79JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41244934
80* GATA1_19941826_ChIP-Seq_K562_Human1.40755139
81PU_27001747_Chip-Seq_BMDM_Mouse1.34955430
82VDR_24787735_ChIP-Seq_THP-1_Human1.33464211
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.33016871
84GATA3_27048872_Chip-Seq_THYMUS_Human1.32607339
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.31960939
86NCOR1_26117541_ChIP-Seq_K562_Human1.31469746
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31317460
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30594331
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30310126
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30225765
91CJUN_26792858_Chip-Seq_BT549_Human1.29365922
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29357248
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27410633
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27004150
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26939880
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25930202
97ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25491355
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19103880
99* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18777493
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18267488
101* GATA2_19941826_ChIP-Seq_K562_Human1.16815095
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16750565
103ELF5_23300383_ChIP-Seq_T47D_Human1.15431278
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13771502
105LXR_22292898_ChIP-Seq_THP-1_Human1.13224365
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.12159923
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12142942
108CLOCK_20551151_ChIP-Seq_293T_Human1.12124034
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11582002
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10440548
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09623724
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09229438
113* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08925060
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08904315
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06409179
116TFEB_21752829_ChIP-Seq_HELA_Human1.04931726
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.03926611
118* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03397057
119VDR_24763502_ChIP-Seq_THP-1_Human1.03316711
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01854368
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01245693
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01094623
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00523193
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99807276
125STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99538537
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98627371
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98234733
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96583395
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95630070
130PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95231290
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94690670
132* UBF1/2_26484160_Chip-Seq_HMECs_Human0.93626010
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93444310
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93155385
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92346803
136CHD1_26751641_Chip-Seq_LNCaP_Human0.91803524
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90481107
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89246686
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88533444
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87825181
141NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87391462
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86940122
143RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86751005
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85566515
145EGR1_19032775_ChIP-ChIP_M12_Human0.85359916
146ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83595521
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82420262
148CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80632353
149* FOXA1_25552417_ChIP-Seq_VCAP_Human0.80423266
150MYB_26560356_Chip-Seq_TH2_Human0.77786911
151TP53_16413492_ChIP-PET_HCT116_Human0.76875370
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76146684
153AHR_22903824_ChIP-Seq_MCF-7_Human0.75401862
154RUNX1_22412390_ChIP-Seq_EML_Mouse0.75360332
155SOX17_20123909_ChIP-Seq_XEN_Mouse0.74598403
156ELK3_25401928_ChIP-Seq_HUVEC_Human0.73710324
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73646054
158NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73646054
159VDR_21846776_ChIP-Seq_THP-1_Human0.73174209
160IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.72728037
161TP63_23658742_ChIP-Seq_EP156T_Human0.70608766
162VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.68086119
163* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.66789057
164SPI1_23547873_ChIP-Seq_NB4_Human0.66179439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.20751578
2MP0000537_abnormal_urethra_morphology3.98621480
3MP0003724_increased_susceptibility_to3.49571200
4MP0008004_abnormal_stomach_pH3.45149455
5MP0004264_abnormal_extraembryonic_tissu3.40751906
6MP0001835_abnormal_antigen_presentation3.29551856
7MP0003303_peritoneal_inflammation3.28169635
8MP0003436_decreased_susceptibility_to3.25324007
9MP0003866_abnormal_defecation3.03622412
10MP0001873_stomach_inflammation2.86066820
11MP0010678_abnormal_skin_adnexa2.84606945
12MP0003300_gastrointestinal_ulcer2.79422432
13MP0000462_abnormal_digestive_system2.56495135
14MP0010352_gastrointestinal_tract_polyps2.55685131
15MP0003191_abnormal_cellular_cholesterol2.53789320
16MP0002419_abnormal_innate_immunity2.48874099
17MP0002796_impaired_skin_barrier2.36643110
18MP0010155_abnormal_intestine_physiology2.35848441
19MP0000383_abnormal_hair_follicle2.34779347
20MP0001800_abnormal_humoral_immune2.32010846
21MP0005451_abnormal_body_composition2.28488805
22MP0003453_abnormal_keratinocyte_physiol2.23069493
23MP0000685_abnormal_immune_system2.22556205
24MP0008260_abnormal_autophagy2.22496231
25MP0005000_abnormal_immune_tolerance2.20385181
26MP0001790_abnormal_immune_system2.16194262
27MP0005387_immune_system_phenotype2.16194262
28MP0000490_abnormal_crypts_of2.10123623
29MP0005671_abnormal_response_to2.08907018
30MP0002452_abnormal_antigen_presenting2.08860774
31MP0002723_abnormal_immune_serum2.05138391
32MP0006054_spinal_hemorrhage2.04907315
33MP0002420_abnormal_adaptive_immunity2.03475652
34MP0001819_abnormal_immune_cell2.02330844
35MP0005464_abnormal_platelet_physiology1.99748756
36MP0000465_gastrointestinal_hemorrhage1.98205274
37MP0001216_abnormal_epidermal_layer1.93421676
38MP0009278_abnormal_bone_marrow1.92239813
39MP0002060_abnormal_skin_morphology1.91604534
40MP0003172_abnormal_lysosome_physiology1.88174650
41MP0005381_digestive/alimentary_phenotyp1.88125692
42MP0005501_abnormal_skin_physiology1.84400983
43MP0003283_abnormal_digestive_organ1.84296465
44MP0001663_abnormal_digestive_system1.84205022
45MP0000477_abnormal_intestine_morphology1.82187410
46MP0006082_CNS_inflammation1.81068332
47MP0001664_abnormal_digestion1.78628189
48MP0002398_abnormal_bone_marrow1.77270916
49MP0003828_pulmonary_edema1.72646646
50MP0003315_abnormal_perineum_morphology1.68026944
51MP0002132_abnormal_respiratory_system1.66796071
52MP0001533_abnormal_skeleton_physiology1.66207256
53MP0002405_respiratory_system_inflammati1.65033531
54MP0005275_abnormal_skin_tensile1.64988175
55MP0002009_preneoplasia1.64392970
56MP0009384_cardiac_valve_regurgitation1.64075056
57MP0004947_skin_inflammation1.63282212
58MP0000716_abnormal_immune_system1.61943082
59MP0002098_abnormal_vibrissa_morphology1.61719958
60MP0005397_hematopoietic_system_phenotyp1.56593581
61MP0001545_abnormal_hematopoietic_system1.56593581
62MP0002166_altered_tumor_susceptibility1.54234474
63MP0000470_abnormal_stomach_morphology1.54155390
64MP0000377_abnormal_hair_follicle1.52424235
65MP0001849_ear_inflammation1.50174476
66MP0003183_abnormal_peptide_metabolism1.47377067
67MP0003950_abnormal_plasma_membrane1.46310453
68MP0003656_abnormal_erythrocyte_physiolo1.44999629
69MP0002722_abnormal_immune_system1.44422539
70MP0004381_abnormal_hair_follicle1.42337014
71MP0003693_abnormal_embryo_hatching1.41979799
72MP0002006_tumorigenesis1.40449303
73MP0005076_abnormal_cell_differentiation1.40171213
74MP0000689_abnormal_spleen_morphology1.39750646
75MP0005023_abnormal_wound_healing1.38613760
76MP0002429_abnormal_blood_cell1.38095385
77MP0010771_integument_phenotype1.37247772
78MP0000467_abnormal_esophagus_morphology1.34811953
79MP0000703_abnormal_thymus_morphology1.30821709
80MP0004808_abnormal_hematopoietic_stem1.30281727
81MP0000762_abnormal_tongue_morphology1.29491273
82MP0001666_abnormal_nutrient_absorption1.28113539
83MP0003566_abnormal_cell_adhesion1.27753868
84MP0005310_abnormal_salivary_gland1.27543531
85MP0003941_abnormal_skin_development1.26207302
86MP0002998_abnormal_bone_remodeling1.24109561
87MP0004883_abnormal_blood_vessel1.22142061
88MP0005058_abnormal_lysosome_morphology1.21385824
89MP0003091_abnormal_cell_migration1.18805492
90MP0000647_abnormal_sebaceous_gland1.14971965
91MP0000538_abnormal_urinary_bladder1.14817635
92MP0005367_renal/urinary_system_phenotyp1.14210195
93MP0000516_abnormal_urinary_system1.14210195
94MP0000613_abnormal_salivary_gland1.12913783
95MP0008469_abnormal_protein_level1.12569668
96MP0002396_abnormal_hematopoietic_system1.12280228
97MP0009785_altered_susceptibility_to1.11001817
98MP0000920_abnormal_myelination1.06185595
99MP0001853_heart_inflammation1.05164880
100MP0002234_abnormal_pharynx_morphology1.04258150
101MP0000579_abnormal_nail_morphology1.02156225
102MP0004272_abnormal_basement_membrane1.01575183
103MP0002877_abnormal_melanocyte_morpholog0.98367087
104MP0001346_abnormal_lacrimal_gland0.98169045
105MP0004957_abnormal_blastocyst_morpholog0.97817716
106MP0005164_abnormal_response_to0.95145322
107MP0009333_abnormal_splenocyte_physiolog0.94491640
108MP0003937_abnormal_limbs/digits/tail_de0.94438822
109MP0000015_abnormal_ear_pigmentation0.93697807
110MP0005193_abnormal_anterior_eye0.89906764
111MP0003221_abnormal_cardiomyocyte_apopto0.89861586
112MP0003806_abnormal_nucleotide_metabolis0.89362565
113MP0000858_altered_metastatic_potential0.89269298
114MP0003075_altered_response_to0.89134666
115MP0009764_decreased_sensitivity_to0.88447292
116MP0005165_increased_susceptibility_to0.87608444
117MP0009840_abnormal_foam_cell0.87336605
118MP0003763_abnormal_thymus_physiology0.86839564
119MP0000566_synostosis0.86490470
120MP0003045_fibrosis0.86125813
121MP0000627_abnormal_mammary_gland0.85853622
122MP0005075_abnormal_melanosome_morpholog0.82146346
123MP0004185_abnormal_adipocyte_glucose0.82103143
124MP0005166_decreased_susceptibility_to0.80513392
125MP0008057_abnormal_DNA_replication0.80325946
126MP0001191_abnormal_skin_condition0.78588361
127MP0009763_increased_sensitivity_to0.77806129
128MP0001243_abnormal_dermal_layer0.77184949
129MP0002019_abnormal_tumor_incidence0.76745367
130MP0001542_abnormal_bone_strength0.76298229
131MP0001765_abnormal_ion_homeostasis0.75405030
132MP0004782_abnormal_surfactant_physiolog0.74808183
133MP0005621_abnormal_cell_physiology0.74533087
134MP0000427_abnormal_hair_cycle0.72505385
135MP0002148_abnormal_hypersensitivity_rea0.72487599
136MP0005025_abnormal_response_to0.71957546
137MP0005409_darkened_coat_color0.71099950
138MP0000569_abnormal_digit_pigmentation0.70994036
139MP0009379_abnormal_foot_pigmentation0.70569022
140MP0003795_abnormal_bone_structure0.70510774
141MP0005390_skeleton_phenotype0.69257520
142MP0004134_abnormal_chest_morphology0.69011916
143MP0003705_abnormal_hypodermis_morpholog0.68697396
144MP0001845_abnormal_inflammatory_respons0.67674752
145MP0002697_abnormal_eye_size0.67331947
146MP0003936_abnormal_reproductive_system0.67169237
147MP0005408_hypopigmentation0.66921465
148MP0002277_abnormal_respiratory_mucosa0.66499408
149MP0010307_abnormal_tumor_latency0.66100613
150MP0000733_abnormal_muscle_development0.65957965
151MP0005083_abnormal_biliary_tract0.64561926
152MP0000249_abnormal_blood_vessel0.63836292
153MP0000609_abnormal_liver_physiology0.63335517
154MP0001851_eye_inflammation0.62880435
155MP0003448_altered_tumor_morphology0.62758514
156MP0000367_abnormal_coat/_hair0.62574198
157MP0000163_abnormal_cartilage_morphology0.62278206
158MP0002092_abnormal_eye_morphology0.60667334
159MP0002933_joint_inflammation0.59135182
160MP0009931_abnormal_skin_appearance0.58451820
161MP0002136_abnormal_kidney_physiology0.57874241
162MP0002111_abnormal_tail_morphology0.55949739
163MP0002896_abnormal_bone_mineralization0.55572847
164MP0008873_increased_physiological_sensi0.55050911

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.83197082
2Recurrent abscess formation (HP:0002722)5.05359399
3Recurrent bacterial skin infections (HP:0005406)5.04272320
4Onycholysis (HP:0001806)4.90091744
5Right ventricular cardiomyopathy (HP:0011663)4.85417989
6Milia (HP:0001056)4.81242672
7Fragile nails (HP:0001808)4.56615704
8Atrophic scars (HP:0001075)4.39442502
9Abnormality of macrophages (HP:0004311)4.25489122
10Myositis (HP:0100614)4.12104819
11Abnormality of the 2nd finger (HP:0004100)3.89710332
12Pustule (HP:0200039)3.86108341
13Recurrent gram-negative bacterial infections (HP:0005420)3.85046084
14Orchitis (HP:0100796)3.83206997
15Plantar hyperkeratosis (HP:0007556)3.69366688
16Ileus (HP:0002595)3.67682977
17Retrobulbar optic neuritis (HP:0100654)3.49095477
18Optic neuritis (HP:0100653)3.49095477
19Abnormal tarsal ossification (HP:0008369)3.45787130
20Elevated erythrocyte sedimentation rate (HP:0003565)3.34514990
21Recurrent fungal infections (HP:0002841)3.33357416
22Mediastinal lymphadenopathy (HP:0100721)3.28352536
23Gingivitis (HP:0000230)3.26815367
24Abnormal foot bone ossification (HP:0010675)3.25284186
25Ureteral stenosis (HP:0000071)3.23734526
26Gastrointestinal infarctions (HP:0005244)3.20532587
27Recurrent skin infections (HP:0001581)3.14445574
28Abnormality of the proximal phalanges of the hand (HP:0009834)3.14020626
29Abnormality of the 1st metacarpal (HP:0010009)3.09006042
30Meningitis (HP:0001287)3.05959195
31Chronic obstructive pulmonary disease (HP:0006510)3.05140474
32Obstructive lung disease (HP:0006536)3.05140474
33Ureteral obstruction (HP:0006000)3.01248413
34Colitis (HP:0002583)2.98690223
35Cellulitis (HP:0100658)2.97906729
36Flat acetabular roof (HP:0003180)2.97746881
37Spontaneous hematomas (HP:0007420)2.97673318
38Micronodular cirrhosis (HP:0001413)2.95237772
39Fragile skin (HP:0001030)2.94851936
40Prolonged bleeding time (HP:0003010)2.94190839
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.88738086
42Urticaria (HP:0001025)2.87064845
43Vasculitis (HP:0002633)2.84097674
44Recurrent viral infections (HP:0004429)2.83531444
45Woolly hair (HP:0002224)2.83091084
46Pterygium (HP:0001059)2.82280977
47Recurrent cutaneous fungal infections (HP:0011370)2.81914827
48Chronic mucocutaneous candidiasis (HP:0002728)2.81914827
49Alopecia of scalp (HP:0002293)2.81257910
50Abnormality of carpal bone ossification (HP:0006257)2.80710369
51Inflammation of the large intestine (HP:0002037)2.79752744
52Short hallux (HP:0010109)2.79659068
53Increased IgE level (HP:0003212)2.78881788
54Abnormality of the distal phalanx of the thumb (HP:0009617)2.77426962
55Keratoconjunctivitis sicca (HP:0001097)2.77208498
56Arterial thrombosis (HP:0004420)2.76829148
57Gastrointestinal inflammation (HP:0004386)2.75791150
58T lymphocytopenia (HP:0005403)2.75146833
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.74512421
60Osteolytic defects of the hand bones (HP:0009699)2.74512421
61Nail dystrophy (HP:0008404)2.73678552
62Gingival bleeding (HP:0000225)2.71025962
63Aplasia/Hypoplasia of the hallux (HP:0008362)2.69854919
64Stomatitis (HP:0010280)2.69852502
65Chest pain (HP:0100749)2.69634386
66Metabolic alkalosis (HP:0200114)2.66320002
67Segmental peripheral demyelination/remyelination (HP:0003481)2.63297004
68Encephalitis (HP:0002383)2.61346031
69Poikiloderma (HP:0001029)2.59729469
70Hyperactive renin-angiotensin system (HP:0000841)2.59409060
71Trismus (HP:0000211)2.59266207
72Epistaxis (HP:0000421)2.58849793
73Abnormality of T cell number (HP:0011839)2.58085862
74Nuclear cataract (HP:0100018)2.57091675
75Abnormality of the distal phalanges of the toes (HP:0010182)2.52684396
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.49451193
77Pili torti (HP:0003777)2.47548175
78Cupped ribs (HP:0000887)2.46755143
79Abnormality of the gastric mucosa (HP:0004295)2.45396787
80Abnormality of the fingertips (HP:0001211)2.44464523
81Septate vagina (HP:0001153)2.44062944
82Abdominal distention (HP:0003270)2.42830143
83Keratoconjunctivitis (HP:0001096)2.42005393
84Osteomyelitis (HP:0002754)2.40259313
85Autoimmune hemolytic anemia (HP:0001890)2.35191891
86Ectropion (HP:0000656)2.34857711
87Focal segmental glomerulosclerosis (HP:0000097)2.33409673
88Congenital ichthyosiform erythroderma (HP:0007431)2.28989478
89Viral hepatitis (HP:0006562)2.28837494
90Pulmonary infiltrates (HP:0002113)2.27613955
91Short nail (HP:0001799)2.27332579
92Parakeratosis (HP:0001036)2.26607591
93Abnormality of the middle phalanges of the toes (HP:0010183)2.26370910
94Abnormal ossification of hand bones (HP:0005921)2.25851130
95Abnormal blistering of the skin (HP:0008066)2.25821635
96Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.25084012
97Symphalangism affecting the phalanges of the hand (HP:0009773)2.24524360
98Premature rupture of membranes (HP:0001788)2.24122207
99Irregular epiphyses (HP:0010582)2.23849364
100Abnormality of the umbilical cord (HP:0010881)2.22386987
101Amyloidosis (HP:0011034)2.22379702
102Abnormal vertebral ossification (HP:0100569)2.22280415
103Nasal polyposis (HP:0100582)2.20677897
104Palmoplantar hyperkeratosis (HP:0000972)2.19784609
105Subacute progressive viral hepatitis (HP:0006572)2.19248965
106Xerostomia (HP:0000217)2.19188580
107Hemoptysis (HP:0002105)2.18777512
108Short middle phalanx of finger (HP:0005819)2.18601081
109Interstitial pulmonary disease (HP:0006530)2.18150492
110Abnormal platelet volume (HP:0011876)2.18109404
111Fatigue (HP:0012378)2.17365256
112Abnormality of oral frenula (HP:0000190)2.15625579
113Cheilitis (HP:0100825)2.14523166
114Increased cerebral lipofuscin (HP:0011813)2.13210575
115Ankyloglossia (HP:0010296)2.13105201
116Stillbirth (HP:0003826)2.13104463
117Abnormality of T cells (HP:0002843)2.13027051
118Hypoplasia of dental enamel (HP:0006297)2.10917398
119IgM deficiency (HP:0002850)2.10826122
120Esophageal atresia (HP:0002032)2.10119504
121Entropion (HP:0000621)2.09978887
122Abnormality of cells of the erythroid lineage (HP:0012130)2.08062825
123Granulocytopenia (HP:0001913)2.05249482
124Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04494617
125Vertebral hypoplasia (HP:0008417)2.04494617
126Abnormality of chloride homeostasis (HP:0011422)2.04375407
127Glomerulosclerosis (HP:0000096)2.04024274
128Recurrent bronchitis (HP:0002837)2.03835869
129Vacuolated lymphocytes (HP:0001922)2.03739343
130Leukocytosis (HP:0001974)2.03626690
131Abnormal hand bone ossification (HP:0010660)2.03195189
132Abnormalities of placenta or umbilical cord (HP:0001194)2.02457078
133Petechiae (HP:0000967)2.01948482
134Palmar hyperkeratosis (HP:0010765)2.01277553
135Congenital, generalized hypertrichosis (HP:0004540)2.00610341
136Ridged nail (HP:0001807)1.99796011
137Malnutrition (HP:0004395)1.99618049
138Chronic otitis media (HP:0000389)1.99243003
139Periodontitis (HP:0000704)1.98905766
140Recurrent sinusitis (HP:0011108)1.98617302
141Progressive sensorineural hearing impairment (HP:0000408)1.97400647
142Hepatosplenomegaly (HP:0001433)1.96909927
143Abnormality of cochlea (HP:0000375)1.96425870
144Curly hair (HP:0002212)1.96257705
145Zonular cataract (HP:0010920)1.95567783
146Flat capital femoral epiphysis (HP:0003370)1.95030702
147Chronic diarrhea (HP:0002028)1.94946804
148Peritonitis (HP:0002586)1.94528872
149Aplasia/hypoplasia of the femur (HP:0005613)1.94311599
150Gastrointestinal stroma tumor (HP:0100723)1.94146623
151Amaurosis fugax (HP:0100576)1.94107773
152Increased serum ferritin (HP:0003281)1.93816655
153Metaphyseal cupping (HP:0003021)1.92679583
154Short phalanx of the thumb (HP:0009660)1.92229706
155Skin ulcer (HP:0200042)1.92227700
156Abnormal number of erythroid precursors (HP:0012131)1.91915287
157Aortic dissection (HP:0002647)1.91826310
158Slow saccadic eye movements (HP:0000514)1.90742760
159Abnormality of the peritoneum (HP:0002585)1.90466705
160Pulmonary embolism (HP:0002204)1.90416020
161Abnormality of glycolipid metabolism (HP:0010969)1.90064646
162Abnormality of liposaccharide metabolism (HP:0010968)1.90064646
163Abnormality of glycosphingolipid metabolism (HP:0004343)1.90064646
164Anorexia (HP:0002039)1.89958257
165Purpura (HP:0000979)1.88467893
166Abnormality of the nasal mucosa (HP:0000433)1.87939921
167Abnormality of placental membranes (HP:0011409)1.87061962
168Amniotic constriction ring (HP:0009775)1.87061962
169Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.85562531
170Autoimmune thrombocytopenia (HP:0001973)1.85446877
171Increased IgM level (HP:0003496)1.84845681
172Neonatal short-limb short stature (HP:0008921)1.84589772
173Hypergammaglobulinemia (HP:0010702)1.83514536
174Myocardial infarction (HP:0001658)1.83490756
175Abnormality of T cell physiology (HP:0011840)1.82313252
176Epiphyseal dysplasia (HP:0002656)1.79882198
177Loss of speech (HP:0002371)1.79707429
178Reduced subcutaneous adipose tissue (HP:0003758)1.79462315
179Panhypogammaglobulinemia (HP:0003139)1.78961942
180Lymphopenia (HP:0001888)1.78720002
181Polycythemia (HP:0001901)1.78463534
182Aortic aneurysm (HP:0004942)1.78035834
183Polygenic inheritance (HP:0010982)1.78031781
184Abnormality of cells of the lymphoid lineage (HP:0012140)1.76946820
185Premature loss of primary teeth (HP:0006323)1.76394598
186Acute hepatic failure (HP:0006554)1.76206260
187Agammaglobulinemia (HP:0004432)1.74864119
188Abnormality of the endocardium (HP:0004306)1.74707005
189Gangrene (HP:0100758)1.74647351
190Hypochromic anemia (HP:0001931)1.74360361
191Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.72413778
192Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.72247609
193Hoarse voice (HP:0001609)1.72014858
194Aplasia cutis congenita (HP:0001057)1.71542295
195Sparse eyelashes (HP:0000653)1.71447495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.33800166
2EPHA24.51237526
3RIPK44.18289180
4MST1R3.21325310
5STK393.17525702
6FRK3.16999151
7PRPF4B3.03438536
8MAP4K12.86578116
9ERN12.56597223
10MAP2K32.50528089
11MAPKAPK52.33437864
12TRIB32.33142717
13EPHB12.30452146
14IRAK42.27664728
15MAP2K22.18973988
16STK102.17035796
17PBK2.15046617
18RPS6KB22.03389730
19TRPM72.02222402
20LRRK21.99307254
21TESK21.98272448
22GRK61.96407731
23EEF2K1.96191791
24MAP3K131.95535247
25SMG11.74755560
26NUAK11.74288659
27TESK11.68194434
28BTK1.66263766
29CDK121.63557345
30MET1.61210954
31LMTK21.60210100
32JAK31.55134978
33MYLK1.54393116
34FES1.50839060
35JAK11.48978986
36FER1.48189478
37PRKG21.38075506
38KSR21.37384919
39TAOK11.36289881
40HCK1.35250240
41EIF2AK31.33655754
42PIM21.32955989
43MAP3K11.32951382
44LATS11.32627176
45PAK41.32448804
46OXSR11.31113396
47PIK3CA1.31001292
48JAK21.30767494
49FGR1.29785270
50NME21.25267171
51YES11.24710267
52LIMK11.24338808
53MKNK11.21373862
54FGFR41.19792950
55MAP3K31.17969814
56BMPR21.16937377
57SYK1.12628555
58SIK31.11369869
59MAP3K21.11097780
60PKN21.09206124
61MAP3K61.08071762
62TNK21.07602149
63BUB11.06473061
64CSF1R1.03636234
65MATK1.02453848
66PTK61.02431640
67MAP3K101.02158514
68EPHB21.01188915
69TTN1.00838610
70FGFR31.00109225
71RPS6KA40.98728114
72BCR0.97422483
73IRAK10.96467484
74MAP3K80.94915371
75LYN0.93627254
76IRAK20.87601759
77BRSK20.87145521
78NME10.85449309
79MARK30.85129295
80PAK20.84934871
81MARK20.84252424
82CAMK2D0.83395370
83PRKCI0.82270991
84ERBB20.82132787
85AURKB0.81820963
86ROCK20.80976371
87NEK90.80522851
88MAPKAPK30.79548469
89DMPK0.77684494
90STK30.77570697
91RAF10.76221339
92MAP3K110.76069635
93NLK0.75246125
94WEE10.75168177
95CDC42BPA0.75144227
96PDPK10.75089475
97PIK3CG0.74673705
98PDK10.73672773
99BLK0.73410493
100RET0.73299650
101TAOK20.72252876
102DDR20.70291441
103PTK20.69279785
104KIT0.69131010
105MAPKAPK20.68931420
106CAMK2B0.66831905
107IKBKE0.65260366
108MAP3K70.63450959
109IRAK30.62669380
110ICK0.61859360
111ERBB30.61636911
112TAOK30.61218645
113PIM10.58739693
114MKNK20.58720937
115HIPK20.57683242
116TTK0.57102215
117MAP2K10.56436780
118ILK0.56126917
119ZAP700.55141833
120NEK60.54671946
121EPHA30.54460889
122CSNK1A1L0.54404164
123SIK10.53966031
124PRKD20.53930741
125CDK40.53104126
126MAPK70.52185406
127MELK0.51695604
128PAK10.49956800
129CLK10.49215995
130PRKCQ0.49004451
131SGK30.48880506
132RPS6KL10.48789783
133RPS6KC10.48789783
134STK240.48587146
135MAP2K60.48304380
136CAMK2G0.48304135
137CSNK1G30.48211893
138MAP3K50.46760317
139CDK60.46578369
140RIPK10.42968226
141ITK0.41290721
142TBK10.41112796
143TXK0.39048176
144IKBKB0.36434977
145MAP3K140.35882076
146CSK0.35803507
147ZAK0.34231984
148WNK40.34173489
149SCYL20.32661861
150TYK20.32349878
151CSNK1G10.31635460
152DYRK1B0.30480548
153TEC0.28770919
154ERBB40.28446326
155MAP3K120.28392388
156STK38L0.28277282
157ROCK10.27218282
158CHUK0.26122653
159SRC0.24688097
160FYN0.24511716
161DAPK30.23846240
162LCK0.22519164

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.12583004
2Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.01501900
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.86609206
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.67065706
5Osteoclast differentiation_Homo sapiens_hsa043802.51395089
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.43024183
7B cell receptor signaling pathway_Homo sapiens_hsa046622.34061086
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.16427322
9Acute myeloid leukemia_Homo sapiens_hsa052212.13628781
10Mineral absorption_Homo sapiens_hsa049782.10389813
11ECM-receptor interaction_Homo sapiens_hsa045122.00724047
12Staphylococcus aureus infection_Homo sapiens_hsa051502.00123764
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.94351878
14Tight junction_Homo sapiens_hsa045301.91225797
15Ribosome_Homo sapiens_hsa030101.88328832
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87335785
17Tuberculosis_Homo sapiens_hsa051521.82319443
18Allograft rejection_Homo sapiens_hsa053301.72828844
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72233264
20Small cell lung cancer_Homo sapiens_hsa052221.71306852
21Glutathione metabolism_Homo sapiens_hsa004801.69091221
22Graft-versus-host disease_Homo sapiens_hsa053321.66410254
23Non-small cell lung cancer_Homo sapiens_hsa052231.66255350
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62441622
25Ether lipid metabolism_Homo sapiens_hsa005651.61705255
26Autoimmune thyroid disease_Homo sapiens_hsa053201.59682095
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55555272
28T cell receptor signaling pathway_Homo sapiens_hsa046601.55319874
29Sphingolipid metabolism_Homo sapiens_hsa006001.54924186
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52132414
31Thyroid cancer_Homo sapiens_hsa052161.49710367
32Herpes simplex infection_Homo sapiens_hsa051681.44729835
33Arachidonic acid metabolism_Homo sapiens_hsa005901.43424342
34Histidine metabolism_Homo sapiens_hsa003401.36077707
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36047148
36Fatty acid elongation_Homo sapiens_hsa000621.35633428
37Salmonella infection_Homo sapiens_hsa051321.32890442
38Adherens junction_Homo sapiens_hsa045201.31209129
39Steroid biosynthesis_Homo sapiens_hsa001001.28188001
40Bladder cancer_Homo sapiens_hsa052191.27849594
41Chemokine signaling pathway_Homo sapiens_hsa040621.25923593
42Shigellosis_Homo sapiens_hsa051311.16369583
43Endometrial cancer_Homo sapiens_hsa052131.16143127
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14959233
45Other glycan degradation_Homo sapiens_hsa005111.14198993
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12348256
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09056450
48DNA replication_Homo sapiens_hsa030301.08793363
49Linoleic acid metabolism_Homo sapiens_hsa005911.08064438
50Toxoplasmosis_Homo sapiens_hsa051451.06719226
51Type I diabetes mellitus_Homo sapiens_hsa049401.06700317
52Prolactin signaling pathway_Homo sapiens_hsa049171.06389221
53Hematopoietic cell lineage_Homo sapiens_hsa046401.05002269
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03877091
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02400159
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02202300
57Renal cell carcinoma_Homo sapiens_hsa052111.02031110
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01348777
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99598228
60VEGF signaling pathway_Homo sapiens_hsa043700.98996427
61Hippo signaling pathway_Homo sapiens_hsa043900.98743371
62N-Glycan biosynthesis_Homo sapiens_hsa005100.98134477
63Phagosome_Homo sapiens_hsa041450.97733578
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97260332
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.94106912
66Focal adhesion_Homo sapiens_hsa045100.92335706
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92215330
68p53 signaling pathway_Homo sapiens_hsa041150.92149145
69Lysosome_Homo sapiens_hsa041420.91624101
70Hepatitis C_Homo sapiens_hsa051600.91469730
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89287720
72Chemical carcinogenesis_Homo sapiens_hsa052040.84485302
73Renin-angiotensin system_Homo sapiens_hsa046140.83770830
74Amoebiasis_Homo sapiens_hsa051460.83377801
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83051891
76Leishmaniasis_Homo sapiens_hsa051400.83037336
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82722003
78Notch signaling pathway_Homo sapiens_hsa043300.80623942
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79403408
80Mismatch repair_Homo sapiens_hsa034300.79250828
81Protein export_Homo sapiens_hsa030600.78765551
82Colorectal cancer_Homo sapiens_hsa052100.78730397
83Inositol phosphate metabolism_Homo sapiens_hsa005620.78035607
84Choline metabolism in cancer_Homo sapiens_hsa052310.77862181
85Insulin resistance_Homo sapiens_hsa049310.76621796
86Malaria_Homo sapiens_hsa051440.75544953
87African trypanosomiasis_Homo sapiens_hsa051430.75472144
88Viral myocarditis_Homo sapiens_hsa054160.75447750
89Pancreatic cancer_Homo sapiens_hsa052120.75369388
90Epstein-Barr virus infection_Homo sapiens_hsa051690.75048250
91Proteasome_Homo sapiens_hsa030500.74606878
92Pertussis_Homo sapiens_hsa051330.74339917
93Legionellosis_Homo sapiens_hsa051340.73621652
94mTOR signaling pathway_Homo sapiens_hsa041500.73416356
95Protein digestion and absorption_Homo sapiens_hsa049740.69924447
96Pancreatic secretion_Homo sapiens_hsa049720.69534339
97HTLV-I infection_Homo sapiens_hsa051660.68477704
98Proteoglycans in cancer_Homo sapiens_hsa052050.67256377
99FoxO signaling pathway_Homo sapiens_hsa040680.66948245
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65762355
101ErbB signaling pathway_Homo sapiens_hsa040120.65375690
102TGF-beta signaling pathway_Homo sapiens_hsa043500.64187620
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.63527091
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.63270674
105Platelet activation_Homo sapiens_hsa046110.62426299
106Fructose and mannose metabolism_Homo sapiens_hsa000510.61914426
107Chronic myeloid leukemia_Homo sapiens_hsa052200.61457384
108HIF-1 signaling pathway_Homo sapiens_hsa040660.61116514
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.61064291
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.60388881
111Viral carcinogenesis_Homo sapiens_hsa052030.59783143
112Prostate cancer_Homo sapiens_hsa052150.59772124
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59131277
114TNF signaling pathway_Homo sapiens_hsa046680.58936648
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58926633
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58720838
117GnRH signaling pathway_Homo sapiens_hsa049120.58186539
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57627415
119Apoptosis_Homo sapiens_hsa042100.57519839
120Systemic lupus erythematosus_Homo sapiens_hsa053220.57269552
121Antigen processing and presentation_Homo sapiens_hsa046120.57259540
122MicroRNAs in cancer_Homo sapiens_hsa052060.56468992
123Pathways in cancer_Homo sapiens_hsa052000.56214038
124Vitamin digestion and absorption_Homo sapiens_hsa049770.56045621
125Rheumatoid arthritis_Homo sapiens_hsa053230.54171817
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52958183
127Influenza A_Homo sapiens_hsa051640.51370265
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.50277315
129Insulin signaling pathway_Homo sapiens_hsa049100.50043833
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49802981
131Nucleotide excision repair_Homo sapiens_hsa034200.48995428
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48783107
133Pentose phosphate pathway_Homo sapiens_hsa000300.48160845
134Glioma_Homo sapiens_hsa052140.48061330
135Galactose metabolism_Homo sapiens_hsa000520.47577028
136Dorso-ventral axis formation_Homo sapiens_hsa043200.47063993
137Vibrio cholerae infection_Homo sapiens_hsa051100.45636132
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45338123
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44855138
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44682824
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.44077393
142Gastric acid secretion_Homo sapiens_hsa049710.43874182
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42665529
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.42452726
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42160822
146Hepatitis B_Homo sapiens_hsa051610.41984337
147Cell cycle_Homo sapiens_hsa041100.41896014
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.41143132
149Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40728773
150Measles_Homo sapiens_hsa051620.40436285
151Endocytosis_Homo sapiens_hsa041440.40008548
152Asthma_Homo sapiens_hsa053100.39337335
153Primary immunodeficiency_Homo sapiens_hsa053400.38964184
154Thyroid hormone synthesis_Homo sapiens_hsa049180.37940647

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