MBOAT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)6.30980399
2negative regulation of execution phase of apoptosis (GO:1900118)6.13258567
3L-alpha-amino acid transmembrane transport (GO:1902475)5.27729229
4cellular ketone body metabolic process (GO:0046950)5.02741944
5positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.80618529
6leukocyte aggregation (GO:0070486)4.78499101
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70251059
8macroautophagy (GO:0016236)4.66915842
9epithelial cell fate commitment (GO:0072148)4.61836281
10regulation of extracellular matrix disassembly (GO:0010715)4.57047709
11glycerophospholipid catabolic process (GO:0046475)4.54101792
12insulin secretion (GO:0030073)4.45242350
13ketone body metabolic process (GO:1902224)4.42142203
14positive regulation of gluconeogenesis (GO:0045722)4.37470255
15peptide hormone processing (GO:0016486)4.35118311
16respiratory chain complex IV assembly (GO:0008535)4.30035176
17T cell migration (GO:0072678)4.22893161
18inositol phosphate catabolic process (GO:0071545)4.22243673
19water-soluble vitamin biosynthetic process (GO:0042364)4.17972850
20signal peptide processing (GO:0006465)4.16549862
21positive thymic T cell selection (GO:0045059)4.14447556
22positive T cell selection (GO:0043368)4.11253712
23sphingomyelin metabolic process (GO:0006684)4.03883731
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.01950352
25phosphorylated carbohydrate dephosphorylation (GO:0046838)3.99420701
26inositol phosphate dephosphorylation (GO:0046855)3.99420701
27nitric oxide biosynthetic process (GO:0006809)3.93503432
28regulation of autophagic vacuole assembly (GO:2000785)3.92053990
29cytochrome complex assembly (GO:0017004)3.91615591
30regulation of glucokinase activity (GO:0033131)3.88602725
31regulation of hexokinase activity (GO:1903299)3.88602725
32positive regulation of histone H3-K4 methylation (GO:0051571)3.87732075
33endocrine pancreas development (GO:0031018)3.87075581
34adult feeding behavior (GO:0008343)3.81155244
35regulation of type B pancreatic cell apoptotic process (GO:2000674)3.77090506
36cellular response to zinc ion (GO:0071294)3.72296584
37positive regulation of gamma-delta T cell activation (GO:0046645)3.64830894
38DNA strand renaturation (GO:0000733)3.62589495
39auditory receptor cell differentiation (GO:0042491)3.60452820
40regulation of vacuole organization (GO:0044088)3.58122896
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.54833999
42L-phenylalanine catabolic process (GO:0006559)3.54833999
43startle response (GO:0001964)3.52684208
44negative regulation of complement activation (GO:0045916)3.52535662
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52259131
46positive regulation of alpha-beta T cell proliferation (GO:0046641)3.51432953
47cellular response to interleukin-15 (GO:0071350)3.50830651
48regulation of execution phase of apoptosis (GO:1900117)3.50353640
49regulation of telomere maintenance via telomerase (GO:0032210)3.46590429
50regulation of Rac protein signal transduction (GO:0035020)3.45374997
51somite rostral/caudal axis specification (GO:0032525)3.44386127
52superoxide anion generation (GO:0042554)3.42132443
53positive regulation of T-helper 1 type immune response (GO:0002827)3.41184297
54regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.38380509
55negative regulation of cytosolic calcium ion concentration (GO:0051481)3.36189436
56toxin transport (GO:1901998)3.34902854
57replication fork processing (GO:0031297)3.33805212
58positive regulation of insulin secretion (GO:0032024)3.33372233
59positive regulation of response to extracellular stimulus (GO:0032106)3.32518525
60positive regulation of response to nutrient levels (GO:0032109)3.32518525
61regulation of T cell receptor signaling pathway (GO:0050856)3.31304824
62negative T cell selection (GO:0043383)3.30013591
63negative regulation of protein activation cascade (GO:2000258)3.16899373
64polyol catabolic process (GO:0046174)3.14983556
65positive regulation of neutrophil migration (GO:1902624)3.14272657
66positive regulation of neutrophil chemotaxis (GO:0090023)3.14272657
67regulation of dendritic cell antigen processing and presentation (GO:0002604)3.11820869
68regulation of alpha-beta T cell proliferation (GO:0046640)3.11710500
69catecholamine transport (GO:0051937)3.11413553
70nephron tubule morphogenesis (GO:0072078)3.10990597
71nephron epithelium morphogenesis (GO:0072088)3.10990597
72phospholipid catabolic process (GO:0009395)3.10914908
73protein localization to Golgi apparatus (GO:0034067)3.10560236
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.09206181
75L-phenylalanine metabolic process (GO:0006558)3.09206181
76leukocyte cell-cell adhesion (GO:0007159)3.09074814
77mast cell activation (GO:0045576)3.08988551
78negative regulation of T cell mediated immunity (GO:0002710)3.08303492
79regulation of isotype switching to IgG isotypes (GO:0048302)3.07928490
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07842621
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07842621
82positive regulation of B cell mediated immunity (GO:0002714)3.07410759
83positive regulation of immunoglobulin mediated immune response (GO:0002891)3.07410759
84toxin metabolic process (GO:0009404)3.07204096
85basic amino acid transport (GO:0015802)3.07071325
86negative regulation of cell killing (GO:0031342)3.04443322
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04443322
88positive regulation of interleukin-12 production (GO:0032735)3.04236333
89regulation of T-helper 1 cell differentiation (GO:0045625)3.04025029
90negative thymic T cell selection (GO:0045060)3.03942075
91negative regulation of viral genome replication (GO:0045071)3.03429524
92protein targeting to Golgi (GO:0000042)3.02872930
93polyketide metabolic process (GO:0030638)3.01288123
94doxorubicin metabolic process (GO:0044598)3.01288123
95daunorubicin metabolic process (GO:0044597)3.01288123
96aromatic amino acid family catabolic process (GO:0009074)3.01120537
97positive regulation of macroautophagy (GO:0016239)2.97334616
98response to peptidoglycan (GO:0032494)2.97298702
99neutrophil activation involved in immune response (GO:0002283)2.96891002
100intra-Golgi vesicle-mediated transport (GO:0006891)2.96196408
101establishment of protein localization to Golgi (GO:0072600)2.95387206
102positive regulation of granulocyte chemotaxis (GO:0071624)2.94822588
103response to pheromone (GO:0019236)2.94321213
104sphingolipid catabolic process (GO:0030149)2.93228786
105maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92951156
106peptide hormone secretion (GO:0030072)2.92828486
107glandular epithelial cell differentiation (GO:0002067)2.90563116
108regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.90293637
109positive regulation of calcium ion import (GO:0090280)2.87697789
110detection of calcium ion (GO:0005513)2.87495055
111G-protein coupled receptor internalization (GO:0002031)2.87156331
112alanine transport (GO:0032328)2.85726645
113peptide secretion (GO:0002790)2.84821873
114regulation of respiratory burst (GO:0060263)2.84217682
115potassium ion export (GO:0071435)2.83768940
116protein complex biogenesis (GO:0070271)2.83653375
117regulation of RIG-I signaling pathway (GO:0039535)2.82885111
118organic cation transport (GO:0015695)2.81388362
119early endosome to late endosome transport (GO:0045022)2.81320139
120immunoglobulin mediated immune response (GO:0016064)2.81161587
121dopamine transport (GO:0015872)2.79510525
122regulation of activation of Janus kinase activity (GO:0010533)2.79406500
123regulation of neurotransmitter uptake (GO:0051580)2.79313310
124T cell receptor signaling pathway (GO:0050852)2.78980643
125positive regulation of antigen processing and presentation (GO:0002579)2.78563294
126B cell mediated immunity (GO:0019724)2.77613162
127regulation of MHC class I biosynthetic process (GO:0045343)2.77475561
128deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.76628828
129regulation of immunoglobulin secretion (GO:0051023)2.76106974
130phenylpropanoid metabolic process (GO:0009698)2.75962643
131antigen processing and presentation of endogenous antigen (GO:0019883)2.72423995
132regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71658985
133nitric oxide mediated signal transduction (GO:0007263)2.71246904
134retinol metabolic process (GO:0042572)2.70692637
135regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.70637020
136cellular response to exogenous dsRNA (GO:0071360)2.70115758
137positive regulation of isotype switching (GO:0045830)2.70058063
138eosinophil chemotaxis (GO:0048245)2.69704010
139regulation of neutrophil migration (GO:1902622)2.69232583
140regulation of neutrophil chemotaxis (GO:0090022)2.69232583
141negative regulation of humoral immune response (GO:0002921)2.68955293
142regulation of insulin secretion (GO:0050796)2.67987247
143negative regulation of cAMP-mediated signaling (GO:0043951)2.67862127
144type I interferon signaling pathway (GO:0060337)2.67695596
145cellular response to type I interferon (GO:0071357)2.67695596
146renal tubule morphogenesis (GO:0061333)2.67591677
147regulation of immunoglobulin mediated immune response (GO:0002889)2.67366836
148brain morphogenesis (GO:0048854)2.67131052
149protein polyglutamylation (GO:0018095)2.66999304
150positive regulation of DNA recombination (GO:0045911)2.66959327
151reverse cholesterol transport (GO:0043691)2.65529059
152positive regulation of defense response to virus by host (GO:0002230)2.65402017
153lactate metabolic process (GO:0006089)2.65399752
154T cell selection (GO:0045058)2.65262236
155nodal signaling pathway (GO:0038092)2.65206024
156response to type I interferon (GO:0034340)2.64330069
157retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63965525
158single strand break repair (GO:0000012)2.62674141
159amyloid precursor protein catabolic process (GO:0042987)2.62553108
160negative regulation of T cell receptor signaling pathway (GO:0050860)2.62110408
161adaptation of signaling pathway (GO:0023058)2.61421220
162membrane lipid catabolic process (GO:0046466)2.61265317
163C-terminal protein lipidation (GO:0006501)2.60942408
164regulation of T cell chemotaxis (GO:0010819)2.60292836
165positive regulation of T cell chemotaxis (GO:0010820)2.60292836
166axoneme assembly (GO:0035082)2.59846636
167positive regulation of peptide hormone secretion (GO:0090277)2.59833866
168energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59612660
169ATP hydrolysis coupled proton transport (GO:0015991)2.59612660
170calcium ion-dependent exocytosis (GO:0017156)2.59540863
171positive regulation of macrophage differentiation (GO:0045651)2.59332751
172regulation of cilium movement (GO:0003352)2.59007824
173zinc ion homeostasis (GO:0055069)2.58745234
174B cell proliferation (GO:0042100)2.58415823
175regulation of mitochondrial translation (GO:0070129)2.55266014
176positive regulation of interleukin-17 production (GO:0032740)2.54764016
177sperm motility (GO:0030317)2.54752208
178regulation of B cell receptor signaling pathway (GO:0050855)2.54410813
179positive regulation of neurotransmitter transport (GO:0051590)2.54200758
180regulation of B cell mediated immunity (GO:0002712)2.53837837
181thymic T cell selection (GO:0045061)2.52790187
182regulation of sister chromatid cohesion (GO:0007063)2.52326252
183negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.51946958
184natural killer cell activation (GO:0030101)2.51683673
185regulation of antigen processing and presentation (GO:0002577)2.51634608
186regulation of T-helper 1 type immune response (GO:0002825)2.51236162
187detection of other organism (GO:0098543)2.50369291
188positive regulation of developmental pigmentation (GO:0048087)2.47646393
189negative regulation of lymphocyte mediated immunity (GO:0002707)2.47353017
190interferon-gamma-mediated signaling pathway (GO:0060333)2.45876209
191regulation of gamma-delta T cell activation (GO:0046643)2.45333594
192positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42970349
193response to protozoan (GO:0001562)2.42689537
194CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41967517
195defense response to protozoan (GO:0042832)2.41898100
196antigen receptor-mediated signaling pathway (GO:0050851)2.41680054
197positive regulation of T-helper cell differentiation (GO:0045624)2.41443313
198regulation of lymphocyte chemotaxis (GO:1901623)2.39765196
199myeloid dendritic cell activation (GO:0001773)2.39756325
200regulation of nuclear cell cycle DNA replication (GO:0033262)2.39593807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.19908306
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.66077787
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.51180033
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.43831001
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.30426607
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.17529924
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.14152790
8SMAD_19615063_ChIP-ChIP_OVARY_Human4.11622354
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.79887353
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.39363232
11TP63_19390658_ChIP-ChIP_HaCaT_Human3.31664869
12E2F7_22180533_ChIP-Seq_HELA_Human3.30115727
13GBX2_23144817_ChIP-Seq_PC3_Human3.11613023
14STAT4_19710469_ChIP-ChIP_TH1__Mouse3.07832038
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.96190161
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.93007240
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81212805
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64704818
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55221819
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.36873342
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27630617
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19689461
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17601496
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08443550
25ZNF274_21170338_ChIP-Seq_K562_Hela1.94960422
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94816328
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94564653
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93438086
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93438086
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93438086
31MYB_26560356_Chip-Seq_TH2_Human1.89938009
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88186702
33IGF1R_20145208_ChIP-Seq_DFB_Human1.83630037
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81680772
35RUNX_20019798_ChIP-Seq_JUKART_Human1.80350840
36HTT_18923047_ChIP-ChIP_STHdh_Human1.80260692
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77471415
38IRF1_19129219_ChIP-ChIP_H3396_Human1.74627334
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72181083
40BCAT_22108803_ChIP-Seq_LS180_Human1.71342383
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70556930
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69703480
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.69244997
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.67084697
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66567296
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.62860045
47P300_19829295_ChIP-Seq_ESCs_Human1.61625918
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61018366
49ER_23166858_ChIP-Seq_MCF-7_Human1.60823910
50SMAD4_21799915_ChIP-Seq_A2780_Human1.60163604
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59484321
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56858116
53* MYB_26560356_Chip-Seq_TH1_Human1.56789893
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55262942
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53605700
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53531027
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.53208642
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.51960081
59SPI1_23547873_ChIP-Seq_NB4_Human1.51638524
60* AR_25329375_ChIP-Seq_VCAP_Human1.49461941
61ELK1_19687146_ChIP-ChIP_HELA_Human1.48521713
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46855136
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43988584
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.42890340
65STAT3_23295773_ChIP-Seq_U87_Human1.41892403
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.39973391
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39515061
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.38031187
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38031187
70TP53_22573176_ChIP-Seq_HFKS_Human1.35483090
71TAF15_26573619_Chip-Seq_HEK293_Human1.34738302
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33928605
73CBP_20019798_ChIP-Seq_JUKART_Human1.33928605
74VDR_23849224_ChIP-Seq_CD4+_Human1.32919110
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31995457
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30267922
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29327230
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28820332
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.27512001
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27508766
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27368516
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26435189
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26369023
84REST_21632747_ChIP-Seq_MESCs_Mouse1.25496776
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23519621
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.23274299
87TCF4_22108803_ChIP-Seq_LS180_Human1.22690550
88NANOG_19829295_ChIP-Seq_ESCs_Human1.21541228
89SOX2_19829295_ChIP-Seq_ESCs_Human1.21541228
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19718036
91TCF4_23295773_ChIP-Seq_U87_Human1.18541383
92GATA3_27048872_Chip-Seq_THYMUS_Human1.18473595
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17193412
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17059327
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16412049
96FUS_26573619_Chip-Seq_HEK293_Human1.14607267
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14335031
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13932979
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13898406
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.13146782
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12303258
102AR_20517297_ChIP-Seq_VCAP_Human1.11870379
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.11846126
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11769955
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11454039
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.11136765
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11033365
108ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10903874
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10594983
110CDX2_22108803_ChIP-Seq_LS180_Human1.10228625
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09000174
112YY1_21170310_ChIP-Seq_MESCs_Mouse1.08431624
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.07967242
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06819938
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06764970
116GABP_17652178_ChIP-ChIP_JURKAT_Human1.06602554
117RUNX2_22187159_ChIP-Seq_PCA_Human1.06451140
118MYC_19829295_ChIP-Seq_ESCs_Human1.06371788
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06233963
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04660940
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03515754
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03045461
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03016055
124NCOR_22424771_ChIP-Seq_293T_Human1.02975758
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02562571
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02251908
127RNF2_27304074_Chip-Seq_NSC_Mouse1.02066112
128ERG_20517297_ChIP-Seq_VCAP_Human1.01402496
129NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01209940
130REST_18959480_ChIP-ChIP_MESCs_Mouse1.01199219
131CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00999734
132GATA3_26560356_Chip-Seq_TH2_Human1.00959196
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00609641
134* MAF_26560356_Chip-Seq_TH1_Human1.00092988
135FOXA1_25552417_ChIP-Seq_VCAP_Human0.99877444
136KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99790081
137ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98888589
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98888487
139SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98082781
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97533913
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97447156
142OCT4_18555785_Chip-Seq_ESCs_Mouse0.96807129
143PU_27001747_Chip-Seq_BMDM_Mouse0.95691930
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.95429196
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.95214218
146SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94889887
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93785375
148TBL1_22424771_ChIP-Seq_293T_Human0.93222268
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.92355294
150POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91611726
151HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91597225
152ZFX_18555785_Chip-Seq_ESCs_Mouse0.91139056
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90541954
154E2F1_18555785_Chip-Seq_ESCs_Mouse0.90413025
155FOXA2_19822575_ChIP-Seq_HepG2_Human0.90137945
156RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87543613
157Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87058497
158KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86902329
159TAL1_26923725_Chip-Seq_HPCs_Mouse0.86289300
160SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85732779
161SOX2_18555785_Chip-Seq_ESCs_Mouse0.84949702
162GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84946737
163P53_22387025_ChIP-Seq_ESCs_Mouse0.84096544
164KLF4_18555785_Chip-Seq_ESCs_Mouse0.83088866
165MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82180767
166EWS_26573619_Chip-Seq_HEK293_Human0.81847453
167FOXP3_21729870_ChIP-Seq_TREG_Human0.81716657
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81173745
169CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81089287
170LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79975316
171MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79909453
172EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79676376
173BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78346827
174CMYC_18555785_Chip-Seq_ESCs_Mouse0.77687577
175STAT3_18555785_ChIP-Seq_MESCs_Mouse0.76619344
176RUNX1_22412390_ChIP-Seq_EML_Mouse0.76002658
177HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.75308314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.52127664
2MP0005379_endocrine/exocrine_gland_phen4.39847380
3MP0009785_altered_susceptibility_to3.74785978
4MP0001835_abnormal_antigen_presentation3.39058214
5MP0002909_abnormal_adrenal_gland3.37181616
6MP0000685_abnormal_immune_system3.27936030
7MP0006082_CNS_inflammation3.27870772
8MP0002254_reproductive_system_inflammat3.25223530
9MP0005645_abnormal_hypothalamus_physiol3.10758620
10MP0000013_abnormal_adipose_tissue2.99283169
11MP0005671_abnormal_response_to2.92756241
12MP0002163_abnormal_gland_morphology2.92461190
13MP0008057_abnormal_DNA_replication2.85459932
14MP0006292_abnormal_olfactory_placode2.84686451
15MP0008877_abnormal_DNA_methylation2.79044401
16MP0002139_abnormal_hepatobiliary_system2.67281694
17MP0003195_calcinosis2.67077539
18MP0005387_immune_system_phenotype2.64554696
19MP0001790_abnormal_immune_system2.64554696
20MP0003136_yellow_coat_color2.63422398
21MP0001944_abnormal_pancreas_morphology2.63294308
22MP0005000_abnormal_immune_tolerance2.61560855
23MP0003724_increased_susceptibility_to2.58639774
24MP0010329_abnormal_lipoprotein_level2.57366644
25MP0002277_abnormal_respiratory_mucosa2.53507564
26MP0005025_abnormal_response_to2.51411127
27MP0003763_abnormal_thymus_physiology2.45297239
28MP0009780_abnormal_chondrocyte_physiolo2.41941123
29MP0004264_abnormal_extraembryonic_tissu2.38939489
30MP0002148_abnormal_hypersensitivity_rea2.35384682
31MP0003436_decreased_susceptibility_to2.31992407
32MP0004270_analgesia2.27460251
33MP0006072_abnormal_retinal_apoptosis2.24567424
34MP0001800_abnormal_humoral_immune2.18008928
35MP0003172_abnormal_lysosome_physiology2.14751463
36MP0002723_abnormal_immune_serum2.07580549
37MP0001819_abnormal_immune_cell2.04497629
38MP0005310_abnormal_salivary_gland2.02609140
39MP0002420_abnormal_adaptive_immunity2.00178967
40MP0005075_abnormal_melanosome_morpholog1.92209367
41MP0003693_abnormal_embryo_hatching1.89645228
42MP0002452_abnormal_antigen_presenting1.87541074
43MP0005646_abnormal_pituitary_gland1.85970839
44MP0003121_genomic_imprinting1.85779612
45MP0005248_abnormal_Harderian_gland1.85759295
46MP0003122_maternal_imprinting1.81616308
47MP0002398_abnormal_bone_marrow1.80724559
48MP0005332_abnormal_amino_acid1.80587464
49MP0002876_abnormal_thyroid_physiology1.75019422
50MP0009046_muscle_twitch1.74899775
51MP0003890_abnormal_embryonic-extraembry1.73445887
52* MP0002078_abnormal_glucose_homeostasis1.69665658
53MP0004019_abnormal_vitamin_homeostasis1.68244946
54MP0000858_altered_metastatic_potential1.67926671
55MP0000716_abnormal_immune_system1.67569978
56MP0005171_absent_coat_pigmentation1.65188640
57MP0005365_abnormal_bile_salt1.63525990
58MP0001501_abnormal_sleep_pattern1.59871317
59MP0010352_gastrointestinal_tract_polyps1.59801285
60MP0000490_abnormal_crypts_of1.58873557
61MP0001756_abnormal_urination1.57438168
62MP0002419_abnormal_innate_immunity1.56259750
63MP0004782_abnormal_surfactant_physiolog1.56057310
64MP0004043_abnormal_pH_regulation1.55564176
65MP0003077_abnormal_cell_cycle1.54812485
66MP0000003_abnormal_adipose_tissue1.52996059
67MP0002405_respiratory_system_inflammati1.51955516
68MP0004381_abnormal_hair_follicle1.51031563
69MP0009764_decreased_sensitivity_to1.49908040
70MP0010386_abnormal_urinary_bladder1.46583830
71MP0002638_abnormal_pupillary_reflex1.41326525
72MP0009333_abnormal_splenocyte_physiolog1.40616844
73MP0000372_irregular_coat_pigmentation1.39422360
74MP0001545_abnormal_hematopoietic_system1.37342699
75MP0005397_hematopoietic_system_phenotyp1.37342699
76MP0002429_abnormal_blood_cell1.35089783
77MP0002722_abnormal_immune_system1.33839205
78MP0002736_abnormal_nociception_after1.32016851
79MP0001765_abnormal_ion_homeostasis1.30080673
80MP0010155_abnormal_intestine_physiology1.29787027
81MP0004947_skin_inflammation1.29659765
82MP0000703_abnormal_thymus_morphology1.29214481
83MP0002090_abnormal_vision1.27911426
84MP0003123_paternal_imprinting1.27505495
85MP0009840_abnormal_foam_cell1.26572995
86* MP0005448_abnormal_energy_balance1.25828504
87MP0005410_abnormal_fertilization1.24929659
88MP0001905_abnormal_dopamine_level1.24624398
89MP0005636_abnormal_mineral_homeostasis1.23765752
90MP0003787_abnormal_imprinting1.23495933
91MP0010094_abnormal_chromosome_stability1.23432937
92MP0003011_delayed_dark_adaptation1.23219775
93MP0009745_abnormal_behavioral_response1.22402009
94MP0006036_abnormal_mitochondrial_physio1.21594266
95MP0004957_abnormal_blastocyst_morpholog1.21546603
96MP0003111_abnormal_nucleus_morphology1.19761413
97MP0000689_abnormal_spleen_morphology1.19431618
98MP0001845_abnormal_inflammatory_respons1.18383268
99MP0002396_abnormal_hematopoietic_system1.16637969
100MP0002132_abnormal_respiratory_system1.16068131
101MP0002295_abnormal_pulmonary_circulatio1.15270721
102* MP0003953_abnormal_hormone_level1.14595420
103MP0002064_seizures1.13592839
104MP0005551_abnormal_eye_electrophysiolog1.13344737
105MP0005535_abnormal_body_temperature1.11427148
106MP0002971_abnormal_brown_adipose1.10015107
107MP0003943_abnormal_hepatobiliary_system1.09434519
108MP0001188_hyperpigmentation1.08248959
109MP0001853_heart_inflammation1.07635665
110MP0002938_white_spotting1.06951518
111MP0003880_abnormal_central_pattern1.05999737
112MP0003828_pulmonary_edema1.05577217
113MP0002733_abnormal_thermal_nociception1.04489669
114MP0001502_abnormal_circadian_rhythm1.04407603
115MP0004133_heterotaxia1.03218202
116MP0004885_abnormal_endolymph1.02993812
117MP0002118_abnormal_lipid_homeostasis1.02860959
118MP0003633_abnormal_nervous_system1.02857445
119MP0000639_abnormal_adrenal_gland1.02372278
120MP0000427_abnormal_hair_cycle1.02338015
121MP0003448_altered_tumor_morphology1.01737368
122MP0008058_abnormal_DNA_repair1.01419746
123MP0005451_abnormal_body_composition0.99721216
124MP0003866_abnormal_defecation0.99128202
125MP0008004_abnormal_stomach_pH0.97575690
126MP0008932_abnormal_embryonic_tissue0.97313509
127MP0005257_abnormal_intraocular_pressure0.97290532
128MP0002166_altered_tumor_susceptibility0.95596930
129MP0010234_abnormal_vibrissa_follicle0.94896441
130MP0004085_abnormal_heartbeat0.94210704
131MP0005058_abnormal_lysosome_morphology0.93919024
132MP0003879_abnormal_hair_cell0.93710955
133MP0002734_abnormal_mechanical_nocicepti0.93485546
134MP0002928_abnormal_bile_duct0.93148871
135MP0004215_abnormal_myocardial_fiber0.92144528
136MP0001533_abnormal_skeleton_physiology0.92055917
137MP0002229_neurodegeneration0.91933059
138MP0000631_abnormal_neuroendocrine_gland0.90049121
139MP0000230_abnormal_systemic_arterial0.89946191
140MP0002272_abnormal_nervous_system0.89902602
141MP0000569_abnormal_digit_pigmentation0.88925064
142MP0002019_abnormal_tumor_incidence0.88100684
143MP0002557_abnormal_social/conspecific_i0.87675271
144MP0001970_abnormal_pain_threshold0.87652519
145MP0005367_renal/urinary_system_phenotyp0.87467508
146MP0000516_abnormal_urinary_system0.87467508
147MP0005464_abnormal_platelet_physiology0.87297538
148MP0001968_abnormal_touch/_nociception0.86270713
149MP0008961_abnormal_basal_metabolism0.86177768
150MP0008872_abnormal_physiological_respon0.85400725
151MP0002009_preneoplasia0.84363373
152MP0005085_abnormal_gallbladder_physiolo0.83065344
153* MP0002069_abnormal_eating/drinking_beha0.82829120
154MP0002006_tumorigenesis0.82776558
155MP0009643_abnormal_urine_homeostasis0.82700795
156MP0003252_abnormal_bile_duct0.80938855
157MP0003786_premature_aging0.80687528
158MP0000613_abnormal_salivary_gland0.80358358
159MP0002098_abnormal_vibrissa_morphology0.80110253
160MP0010307_abnormal_tumor_latency0.79786088
161MP0003959_abnormal_lean_body0.79644437
162MP0005390_skeleton_phenotype0.79414876
163MP0003283_abnormal_digestive_organ0.76514781
164MP0002693_abnormal_pancreas_physiology0.76282231
165MP0002160_abnormal_reproductive_system0.75490351
166MP0002138_abnormal_hepatobiliary_system0.74788338
167MP0002572_abnormal_emotion/affect_behav0.72831746
168MP0008469_abnormal_protein_level0.72319409
169MP0005253_abnormal_eye_physiology0.72201270
170MP0006035_abnormal_mitochondrial_morpho0.72134195
171* MP0005452_abnormal_adipose_tissue0.72091690
172MP0001486_abnormal_startle_reflex0.70181828
173MP0001485_abnormal_pinna_reflex0.69788176
174MP0005386_behavior/neurological_phenoty0.69774891
175MP0004924_abnormal_behavior0.69774891
176MP0000538_abnormal_urinary_bladder0.69244787
177MP0008995_early_reproductive_senescence0.68205365
178MP0006054_spinal_hemorrhage0.68023714
179MP0005220_abnormal_exocrine_pancreas0.67458707
180MP0000470_abnormal_stomach_morphology0.67202831
181MP0000627_abnormal_mammary_gland0.66656454
182MP0003045_fibrosis0.65915998
183MP0009278_abnormal_bone_marrow0.64645262
184MP0005084_abnormal_gallbladder_morpholo0.63172430
185MP0000343_altered_response_to0.62548714
186MP0008007_abnormal_cellular_replicative0.62383613
187MP0004808_abnormal_hematopoietic_stem0.62067723

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)7.81517716
2Stomatitis (HP:0010280)5.21980244
3Large for gestational age (HP:0001520)5.04002432
4Intestinal atresia (HP:0011100)4.79356951
5Congenital malformation of the right heart (HP:0011723)4.70061185
6Double outlet right ventricle (HP:0001719)4.70061185
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.47785575
8Eczematoid dermatitis (HP:0000976)4.19974674
9Autoimmune hemolytic anemia (HP:0001890)4.06900856
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.01615607
11Increased CSF protein (HP:0002922)4.00112824
12Chromsome breakage (HP:0040012)3.96498580
13Hyperglycemia (HP:0003074)3.91665422
14Vacuolated lymphocytes (HP:0001922)3.85494872
15Vascular calcification (HP:0004934)3.50619717
16Recurrent gram-negative bacterial infections (HP:0005420)3.41423546
17Meckel diverticulum (HP:0002245)3.41228911
18Pancreatic islet-cell hyperplasia (HP:0004510)3.39228072
19IgG deficiency (HP:0004315)3.35045560
20Insulin-resistant diabetes mellitus (HP:0000831)3.34233808
21Ketoacidosis (HP:0001993)3.31008430
22Abnormality of the ileum (HP:0001549)3.29511175
23Gingivitis (HP:0000230)3.28775145
24Hyperinsulinemic hypoglycemia (HP:0000825)3.24839448
25Progressive neurologic deterioration (HP:0002344)3.22680823
26Hypothermia (HP:0002045)3.16755826
27Elevated erythrocyte sedimentation rate (HP:0003565)3.15745202
28Abnormality of the preputium (HP:0100587)3.15218223
29Aplasia/Hypoplasia of the uvula (HP:0010293)3.15206508
30T lymphocytopenia (HP:0005403)3.09547269
31Abnormality of T cell number (HP:0011839)3.09236038
32Abnormality of vitamin B metabolism (HP:0004340)3.01088789
33Cardiovascular calcification (HP:0011915)2.99111543
34Combined immunodeficiency (HP:0005387)2.95155499
35Nasal polyposis (HP:0100582)2.91594779
36Abnormal ciliary motility (HP:0012262)2.91424499
37Orchitis (HP:0100796)2.88523689
38Hemiparesis (HP:0001269)2.88410534
39Myositis (HP:0100614)2.84289918
40Postural tremor (HP:0002174)2.84075930
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.83419290
42Hypoplasia of the fovea (HP:0007750)2.83419290
43Hypoalbuminemia (HP:0003073)2.82416096
44Abnormal albumin level (HP:0012116)2.82416096
45Abnormality of chromosome stability (HP:0003220)2.76624029
46Congenital sensorineural hearing impairment (HP:0008527)2.76226882
47Chronic sinusitis (HP:0011109)2.74646178
48Agitation (HP:0000713)2.73360251
49Glycosuria (HP:0003076)2.72221388
50Abnormality of urine glucose concentration (HP:0011016)2.72221388
51Severe Myopia (HP:0011003)2.69885717
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68386037
53Recurrent bronchitis (HP:0002837)2.67854846
54Occipital encephalocele (HP:0002085)2.65969235
55Hypergammaglobulinemia (HP:0010702)2.65091440
56Optic neuritis (HP:0100653)2.63709020
57Retrobulbar optic neuritis (HP:0100654)2.63709020
58Severe combined immunodeficiency (HP:0004430)2.63592401
59Medial flaring of the eyebrow (HP:0010747)2.62063814
60Abnormality of T cells (HP:0002843)2.61974838
61Cheilitis (HP:0100825)2.60631359
62Severe visual impairment (HP:0001141)2.60590095
63Clubbing of toes (HP:0100760)2.58850992
64Recurrent abscess formation (HP:0002722)2.58630304
65Renal cortical cysts (HP:0000803)2.58399948
663-Methylglutaconic aciduria (HP:0003535)2.56871749
67Hypokinesia (HP:0002375)2.55552598
68Nephronophthisis (HP:0000090)2.54370628
69Obstructive lung disease (HP:0006536)2.54037413
70Chronic obstructive pulmonary disease (HP:0006510)2.54037413
71Ketosis (HP:0001946)2.50916074
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50606368
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50606368
74Abnormality of polysaccharide metabolism (HP:0011012)2.50606368
75Mucopolysacchariduria (HP:0008155)2.46230921
76Urinary glycosaminoglycan excretion (HP:0003541)2.46230921
77Abnormality of dental color (HP:0011073)2.44809901
78Recurrent fungal infections (HP:0002841)2.44155007
79IgA deficiency (HP:0002720)2.42707119
80Chronic otitis media (HP:0000389)2.41468787
81Abnormality of the fovea (HP:0000493)2.36767987
82Aplastic anemia (HP:0001915)2.36353432
83Mediastinal lymphadenopathy (HP:0100721)2.36010141
84Acute necrotizing encephalopathy (HP:0006965)2.34533769
85Abnormal respiratory motile cilium physiology (HP:0012261)2.34035518
86Progressive macrocephaly (HP:0004481)2.33475033
87Orthostatic hypotension (HP:0001278)2.30267327
88Attenuation of retinal blood vessels (HP:0007843)2.29787993
89Hypochromic anemia (HP:0001931)2.29493259
90Prolonged partial thromboplastin time (HP:0003645)2.29476075
91Syncope (HP:0001279)2.29358358
92Asplenia (HP:0001746)2.28822479
93Duodenal stenosis (HP:0100867)2.28604604
94Small intestinal stenosis (HP:0012848)2.28604604
95Prolonged neonatal jaundice (HP:0006579)2.28339228
96Prolonged QT interval (HP:0001657)2.28271814
97Retinal atrophy (HP:0001105)2.27986029
98Abnormality of midbrain morphology (HP:0002418)2.27606876
99Molar tooth sign on MRI (HP:0002419)2.27606876
100Duplicated collecting system (HP:0000081)2.26514338
101Mitochondrial inheritance (HP:0001427)2.26064450
102Abnormality of vitamin metabolism (HP:0100508)2.26050573
103Polydipsia (HP:0001959)2.25996313
104Abnormal drinking behavior (HP:0030082)2.25996313
105Abnormal hair whorl (HP:0010721)2.24642617
106Micronodular cirrhosis (HP:0001413)2.24439664
107Alveolar cell carcinoma (HP:0006519)2.24376616
108Poor suck (HP:0002033)2.22383526
109Absent thumb (HP:0009777)2.21950464
110Ureteral duplication (HP:0000073)2.19877942
111Abnormality of the renal medulla (HP:0100957)2.19311002
112Hyperlipoproteinemia (HP:0010980)2.18927898
113Xanthomatosis (HP:0000991)2.18435224
114Type I transferrin isoform profile (HP:0003642)2.17779522
115Abdominal situs inversus (HP:0003363)2.16776172
116Abnormality of abdominal situs (HP:0011620)2.16776172
117Supernumerary spleens (HP:0009799)2.14443160
118Abnormality of the renal collecting system (HP:0004742)2.14171884
119Type 2 muscle fiber atrophy (HP:0003554)2.14150719
120Muscle fiber atrophy (HP:0100295)2.13952264
121Muscular hypotonia of the trunk (HP:0008936)2.13895395
122Hypoglycemic coma (HP:0001325)2.12302852
123Bronchiectasis (HP:0002110)2.12096812
124Myelodysplasia (HP:0002863)2.11312978
125Absent radius (HP:0003974)2.07852655
126Abnormality of glycolipid metabolism (HP:0010969)2.07780624
127Abnormality of liposaccharide metabolism (HP:0010968)2.07780624
128Abnormality of glycosphingolipid metabolism (HP:0004343)2.07780624
129EEG with generalized epileptiform discharges (HP:0011198)2.07132873
130Episodic fever (HP:0001954)2.06998283
131Abnormal EKG (HP:0003115)2.06878093
132Nephroblastoma (Wilms tumor) (HP:0002667)2.06080662
133Acute encephalopathy (HP:0006846)2.05549313
134Abnormality of T cell physiology (HP:0011840)2.05497713
135Gastrointestinal atresia (HP:0002589)2.04610007
136Abnormal biliary tract morphology (HP:0012440)2.04453350
137Embryonal renal neoplasm (HP:0011794)2.04287663
138Late onset (HP:0003584)2.03967980
139Polyphagia (HP:0002591)2.02658430
140Hypobetalipoproteinemia (HP:0003563)2.02304870
141Pustule (HP:0200039)2.01984920
142Hepatocellular necrosis (HP:0001404)2.01957045
143Cone-rod dystrophy (HP:0000548)2.01663175
144Increased CSF lactate (HP:0002490)2.00972331
145Aplasia/Hypoplasia of the spleen (HP:0010451)2.00633402
146Neoplasm of the tracheobronchial system (HP:0100552)1.97067477
147Hypsarrhythmia (HP:0002521)1.96121394
148Mitral stenosis (HP:0001718)1.95953348
149Epileptiform EEG discharges (HP:0011182)1.95818188
150Resting tremor (HP:0002322)1.95249969
151Subacute progressive viral hepatitis (HP:0006572)1.94834131
152Dysostosis multiplex (HP:0000943)1.94310873
153Renal Fanconi syndrome (HP:0001994)1.93490167
154Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92449579
155Macroorchidism (HP:0000053)1.92439392
156Diminished movement (HP:0002374)1.92410146
157Abnormality of macrophages (HP:0004311)1.92216114
158Recurrent bacterial skin infections (HP:0005406)1.91882182
159Abnormality of endocrine pancreas physiology (HP:0012093)1.91043778
160Abnormality of the pancreatic islet cells (HP:0006476)1.91043778
161Abnormality of renal resorption (HP:0011038)1.90407611
162Bony spicule pigmentary retinopathy (HP:0007737)1.90119615
163Tongue fasciculations (HP:0001308)1.89992041
164Hypoglycemic seizures (HP:0002173)1.89296757
165Menstrual irregularities (HP:0000858)1.88973420
166Abnormal mitochondria in muscle tissue (HP:0008316)1.88482354
167Abnormality of DNA repair (HP:0003254)1.87575812
168Aplasia involving forearm bones (HP:0009822)1.87160367
169Absent forearm bone (HP:0003953)1.87160367
170Generalized aminoaciduria (HP:0002909)1.86370306
171Amelogenesis imperfecta (HP:0000705)1.86310260
172Pancreatic cysts (HP:0001737)1.86172973
173Hepatic necrosis (HP:0002605)1.86080125
174Basal ganglia calcification (HP:0002135)1.85135863
175Abnormality of the nasal mucosa (HP:0000433)1.84322479
176Submucous cleft hard palate (HP:0000176)1.82557095
177Increased hepatocellular lipid droplets (HP:0006565)1.81634756
178Abnormal rod and cone electroretinograms (HP:0008323)1.81132345
179Hematochezia (HP:0002573)1.80362808
180Bone marrow hypocellularity (HP:0005528)1.80206274
181Autoimmune thrombocytopenia (HP:0001973)1.80192143
182Triphalangeal thumb (HP:0001199)1.79708650
183Decreased circulating renin level (HP:0003351)1.78871901
184Abnormality of the duodenum (HP:0002246)1.78521021
185Abnormality of the renal cortex (HP:0011035)1.77816363
186Bronchitis (HP:0012387)1.77636848
187Stomach cancer (HP:0012126)1.77616109
188Aplasia/Hypoplasia of the macula (HP:0008059)1.77297023
189Intestinal fistula (HP:0100819)1.76930950
190Abnormality of the umbilical cord (HP:0010881)1.76581458
191Enlarged kidneys (HP:0000105)1.75183206
192Abnormality of the fingertips (HP:0001211)1.73246457
193Reticulocytopenia (HP:0001896)1.72050920
194Pancreatic fibrosis (HP:0100732)1.69827164
195Broad nasal tip (HP:0000455)1.69770572
196Flat capital femoral epiphysis (HP:0003370)1.68621299
197Abnormal biliary tract physiology (HP:0012439)1.68384209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.64979663
2TXK5.34832493
3MAP3K124.60529376
4STK38L3.99955713
5MAP3K143.62710696
6DAPK22.53029832
7ACVR1B2.49900862
8EIF2AK12.45198784
9PHKG12.35760752
10PHKG22.35760752
11STK242.28149818
12ZAP702.25016331
13GRK12.21620162
14AKT32.17596909
15WNK32.17456191
16PIM22.02956844
17MAP4K21.94718720
18EPHA31.81312739
19MAP3K41.80156194
20INSRR1.77560573
21MAP4K11.75948555
22CDK31.74396237
23EIF2AK31.71558007
24FGFR21.68506246
25PAK31.66848188
26MAPK151.60410663
27MUSK1.57073886
28MST41.53132392
29TRIM281.52868032
30CSNK1G21.49092619
31FGFR31.48473902
32IKBKB1.43456163
33NEK91.41839225
34UHMK11.37834255
35CHUK1.35609553
36EIF2AK21.35409688
37ADRBK21.34410003
38NTRK31.33211242
39CDK121.30632309
40NLK1.30192115
41TBK11.24560687
42CAMKK21.22884680
43MAPK131.18794096
44IRAK21.18190582
45IKBKE1.17018769
46IRAK41.15170229
47JAK31.15009612
48MAP3K111.14801392
49BRAF1.13897908
50SRPK11.13508750
51STK101.13169842
52CSK1.11182479
53TESK11.11004191
54VRK11.09419391
55PTK2B1.08570366
56NTRK21.08178248
57MARK31.07101915
58IRAK11.05087022
59CAMK2D1.04991086
60TRPM71.02811286
61TEC1.02052949
62ITK1.01976154
63TTK1.01561979
64FGFR40.97105083
65DAPK10.96985911
66ARAF0.93913599
67MAP3K60.93467073
68TESK20.92888066
69PRKCG0.91756088
70PRKCI0.91125321
71PIM10.86910551
72BMPR1B0.86211909
73MYLK0.86108830
74MAP2K70.83977484
75MAP2K60.83953837
76PAK40.83479589
77BLK0.82741356
78LCK0.81600038
79MAPK70.81152971
80NEK10.80496557
81PINK10.80280641
82ERN10.78612909
83NEK60.77594430
84WNK40.77209850
85BMPR20.75405184
86STK30.74925338
87HIPK20.74154581
88TNK20.73890372
89MKNK20.72183574
90SGK20.71243611
91ZAK0.71091216
92GRK60.70638074
93RPS6KA40.70249869
94EPHB10.69784143
95DYRK30.67838095
96SYK0.67627664
97ICK0.66281351
98MAPK110.65056745
99LYN0.65003387
100TAOK30.64329331
101BTK0.64086002
102CAMK1G0.63605214
103CSNK1G10.63420029
104RPS6KL10.62978755
105RPS6KC10.62978755
106PNCK0.61920721
107ATR0.61545660
108PRPF4B0.61192558
109NEK20.60908053
110ERBB30.60097869
111GRK70.59515263
112PRKCQ0.59428661
113OXSR10.59072663
114CSNK1D0.58294715
115BRSK20.56958301
116STK380.56918143
117MAP3K130.56739540
118TAF10.56442039
119RPS6KA60.56119682
120RPS6KA50.55563035
121JAK10.55328216
122YES10.55039569
123SIK30.54542678
124GRK50.54540290
125PLK10.53115840
126TNIK0.52571242
127CASK0.52134490
128PRKG10.51784943
129PRKAA20.51050224
130NME10.49721206
131PRKCE0.49081183
132PRKD20.48962146
133EPHA20.48472002
134CHEK20.47031390
135ADRBK10.46778904
136MAP3K20.46486381
137CSNK1A1L0.45611634
138PRKG20.44330382
139STK110.43755024
140MAP3K50.43337575
141SGK4940.42733694
142SGK2230.42733694
143PRKCD0.42449999
144PDK10.42062973
145HCK0.42002577
146CSNK1G30.41636289
147PBK0.40314573
148EPHA40.40125483
149PLK20.40025490
150CDK70.40012537
151SGK30.39848963
152TSSK60.39527841
153PRKACB0.39463508
154WNK10.39405152
155CSNK1A10.38827233
156PRKACA0.37780039
157MAP2K40.37520163
158FER0.37391695
159PRKAA10.36634828
160PASK0.36430279
161STK390.36349119
162PRKCA0.34888214
163ROCK20.32733055

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.95772887
2Allograft rejection_Homo sapiens_hsa053303.16251331
3Primary immunodeficiency_Homo sapiens_hsa053403.14542435
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.01488359
5Asthma_Homo sapiens_hsa053102.88663436
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.71976983
7Insulin secretion_Homo sapiens_hsa049112.67097283
8Autoimmune thyroid disease_Homo sapiens_hsa053202.56906180
9Sulfur metabolism_Homo sapiens_hsa009202.49849787
10Antigen processing and presentation_Homo sapiens_hsa046122.46677072
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39896448
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34623954
13Oxidative phosphorylation_Homo sapiens_hsa001902.30377937
14Butanoate metabolism_Homo sapiens_hsa006502.28437627
15Folate biosynthesis_Homo sapiens_hsa007902.17609412
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.12806565
17NF-kappa B signaling pathway_Homo sapiens_hsa040642.08527930
18Measles_Homo sapiens_hsa051622.00948411
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98065626
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.95528719
21Circadian rhythm_Homo sapiens_hsa047101.86395970
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81294689
23Fanconi anemia pathway_Homo sapiens_hsa034601.76864423
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76025019
25Sphingolipid metabolism_Homo sapiens_hsa006001.75740638
26Legionellosis_Homo sapiens_hsa051341.75444155
27Rheumatoid arthritis_Homo sapiens_hsa053231.72641853
28Hematopoietic cell lineage_Homo sapiens_hsa046401.69896962
29Herpes simplex infection_Homo sapiens_hsa051681.69158776
30Homologous recombination_Homo sapiens_hsa034401.60018855
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59252219
32Vitamin B6 metabolism_Homo sapiens_hsa007501.51398334
33Leishmaniasis_Homo sapiens_hsa051401.50225415
34T cell receptor signaling pathway_Homo sapiens_hsa046601.47635957
35Selenocompound metabolism_Homo sapiens_hsa004501.46361874
36Type I diabetes mellitus_Homo sapiens_hsa049401.45240553
37Tryptophan metabolism_Homo sapiens_hsa003801.45106023
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44869555
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38627047
40Regulation of autophagy_Homo sapiens_hsa041401.34872424
41Protein export_Homo sapiens_hsa030601.32372536
42Collecting duct acid secretion_Homo sapiens_hsa049661.30577103
43Base excision repair_Homo sapiens_hsa034101.28960353
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28598606
45Viral myocarditis_Homo sapiens_hsa054161.25259532
46ABC transporters_Homo sapiens_hsa020101.24503271
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22822334
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.22539128
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22533753
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.22522854
51Malaria_Homo sapiens_hsa051441.22405364
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20936484
53Peroxisome_Homo sapiens_hsa041461.16740475
54Amphetamine addiction_Homo sapiens_hsa050311.15805374
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14135156
56Parkinsons disease_Homo sapiens_hsa050121.13393142
57Influenza A_Homo sapiens_hsa051641.10669715
58Other glycan degradation_Homo sapiens_hsa005111.10078214
59Circadian entrainment_Homo sapiens_hsa047131.08804799
60Phototransduction_Homo sapiens_hsa047441.04488060
61Renin secretion_Homo sapiens_hsa049241.04366493
62Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02343901
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02340042
64Glutathione metabolism_Homo sapiens_hsa004801.01186906
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00307745
66Glucagon signaling pathway_Homo sapiens_hsa049221.00109716
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98317676
68Basal transcription factors_Homo sapiens_hsa030220.97457317
69Alzheimers disease_Homo sapiens_hsa050100.95576920
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95068959
71RNA degradation_Homo sapiens_hsa030180.93812739
72Arachidonic acid metabolism_Homo sapiens_hsa005900.93598826
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89638899
74Type II diabetes mellitus_Homo sapiens_hsa049300.87738349
75Propanoate metabolism_Homo sapiens_hsa006400.87567484
76Vibrio cholerae infection_Homo sapiens_hsa051100.87223936
77Proteasome_Homo sapiens_hsa030500.85651480
78Dopaminergic synapse_Homo sapiens_hsa047280.85037330
79TNF signaling pathway_Homo sapiens_hsa046680.83713504
80Apoptosis_Homo sapiens_hsa042100.81648037
81Thyroid cancer_Homo sapiens_hsa052160.81371662
82Mineral absorption_Homo sapiens_hsa049780.81198890
83DNA replication_Homo sapiens_hsa030300.81160355
84Cell cycle_Homo sapiens_hsa041100.79611276
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79574841
86Acute myeloid leukemia_Homo sapiens_hsa052210.79510218
87Arginine biosynthesis_Homo sapiens_hsa002200.79448936
88Staphylococcus aureus infection_Homo sapiens_hsa051500.77883424
89Nucleotide excision repair_Homo sapiens_hsa034200.77463794
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77406182
91Osteoclast differentiation_Homo sapiens_hsa043800.76670676
92Shigellosis_Homo sapiens_hsa051310.76402433
93N-Glycan biosynthesis_Homo sapiens_hsa005100.75286889
94Pertussis_Homo sapiens_hsa051330.75215618
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74012998
96Tuberculosis_Homo sapiens_hsa051520.73093830
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72630388
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71702498
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71584689
100Chemical carcinogenesis_Homo sapiens_hsa052040.71418367
101Complement and coagulation cascades_Homo sapiens_hsa046100.70896022
102Phagosome_Homo sapiens_hsa041450.70505234
103Retinol metabolism_Homo sapiens_hsa008300.70447604
104Metabolic pathways_Homo sapiens_hsa011000.69819298
105GABAergic synapse_Homo sapiens_hsa047270.68826261
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65949384
107Salmonella infection_Homo sapiens_hsa051320.65883609
108Mismatch repair_Homo sapiens_hsa034300.65144726
109Hepatitis B_Homo sapiens_hsa051610.65005374
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64713575
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64445524
112Dorso-ventral axis formation_Homo sapiens_hsa043200.63510700
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.62406325
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62016272
115RNA polymerase_Homo sapiens_hsa030200.61874287
116Nitrogen metabolism_Homo sapiens_hsa009100.61412983
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.61199335
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60848835
119p53 signaling pathway_Homo sapiens_hsa041150.60766656
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60014631
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59540488
122Fatty acid elongation_Homo sapiens_hsa000620.59474829
123Synaptic vesicle cycle_Homo sapiens_hsa047210.58762073
124beta-Alanine metabolism_Homo sapiens_hsa004100.58715517
125Cardiac muscle contraction_Homo sapiens_hsa042600.58454804
126Cocaine addiction_Homo sapiens_hsa050300.56877711
127Chemokine signaling pathway_Homo sapiens_hsa040620.55060675
128cAMP signaling pathway_Homo sapiens_hsa040240.53993066
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53316882
130Hepatitis C_Homo sapiens_hsa051600.53115291
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52262994
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51820011
133Thyroid hormone synthesis_Homo sapiens_hsa049180.50507908
134Long-term depression_Homo sapiens_hsa047300.50098466
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49535188
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48707026
137Fat digestion and absorption_Homo sapiens_hsa049750.48502081
138Salivary secretion_Homo sapiens_hsa049700.48459623
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.47994978
140Epstein-Barr virus infection_Homo sapiens_hsa051690.47814441
141Pancreatic secretion_Homo sapiens_hsa049720.47475670
142RNA transport_Homo sapiens_hsa030130.47322731
143HTLV-I infection_Homo sapiens_hsa051660.46694296
144Huntingtons disease_Homo sapiens_hsa050160.46226770
145Colorectal cancer_Homo sapiens_hsa052100.45919730
146Toxoplasmosis_Homo sapiens_hsa051450.44740101
147Calcium signaling pathway_Homo sapiens_hsa040200.44282115
148Fatty acid metabolism_Homo sapiens_hsa012120.43945943
149Adherens junction_Homo sapiens_hsa045200.43291147
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.43111941
151African trypanosomiasis_Homo sapiens_hsa051430.42898595
152Pyrimidine metabolism_Homo sapiens_hsa002400.42210039
153Linoleic acid metabolism_Homo sapiens_hsa005910.42003549
154Arginine and proline metabolism_Homo sapiens_hsa003300.41091401
155Morphine addiction_Homo sapiens_hsa050320.40159709
156Fatty acid degradation_Homo sapiens_hsa000710.36118014
157Spliceosome_Homo sapiens_hsa030400.35788536
158Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35746088
159Ribosome_Homo sapiens_hsa030100.35302942
160Olfactory transduction_Homo sapiens_hsa047400.33369346
161Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33160136
162Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32021692
163Caffeine metabolism_Homo sapiens_hsa002320.30963118
164FoxO signaling pathway_Homo sapiens_hsa040680.30652806
165Nicotine addiction_Homo sapiens_hsa050330.30214978
166Serotonergic synapse_Homo sapiens_hsa047260.28950825
167Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28915890
168Inositol phosphate metabolism_Homo sapiens_hsa005620.28154150
169Lysosome_Homo sapiens_hsa041420.27993730
170Viral carcinogenesis_Homo sapiens_hsa052030.27179691
171Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26269504
172alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25497156
173TGF-beta signaling pathway_Homo sapiens_hsa043500.23904133
174Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23119431
175Ether lipid metabolism_Homo sapiens_hsa005650.20236627

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