MBOAT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.27195539
2synaptic vesicle maturation (GO:0016188)6.22274107
3locomotory exploration behavior (GO:0035641)5.86919606
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56807572
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.46589815
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.46589815
7modulation by symbiont of host immune response (GO:0052553)5.46589815
8positive regulation by symbiont of host defense response (GO:0052509)5.46589815
9modulation by symbiont of host defense response (GO:0052031)5.46589815
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.46589815
11vocalization behavior (GO:0071625)5.44226430
12synaptic vesicle exocytosis (GO:0016079)5.29165517
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.25102276
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.25010374
15negative regulation of cell killing (GO:0031342)5.25010374
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.23554083
17antigen processing and presentation of endogenous antigen (GO:0019883)5.16159033
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15326003
19glutamate secretion (GO:0014047)5.11633440
20regulation of synaptic vesicle exocytosis (GO:2000300)5.01688392
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.97063445
22regulation of glutamate receptor signaling pathway (GO:1900449)4.78018364
23response to peptidoglycan (GO:0032494)4.76476842
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.70629448
25neuron cell-cell adhesion (GO:0007158)4.69421702
26neutrophil activation involved in immune response (GO:0002283)4.67462563
27neurotransmitter secretion (GO:0007269)4.65455194
28exploration behavior (GO:0035640)4.52390949
29proline transport (GO:0015824)4.49515755
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.47450790
31detection of other organism (GO:0098543)4.45985609
32sodium ion export (GO:0071436)4.45723428
33regulation of synaptic vesicle transport (GO:1902803)4.45578471
34positive regulation of gamma-delta T cell activation (GO:0046645)4.41971583
35negative regulation of erythrocyte differentiation (GO:0045647)4.41693778
36protein localization to synapse (GO:0035418)4.36544239
37detection of bacterium (GO:0016045)4.33621958
38regulation of neuronal synaptic plasticity (GO:0048168)4.30741399
39regulation of long-term neuronal synaptic plasticity (GO:0048169)4.25024691
40gamma-aminobutyric acid transport (GO:0015812)4.23087714
41dendritic spine morphogenesis (GO:0060997)4.21819399
42cellular potassium ion homeostasis (GO:0030007)4.21257393
43synaptic vesicle docking involved in exocytosis (GO:0016081)4.18286953
44macrophage activation involved in immune response (GO:0002281)4.18150049
45leukocyte aggregation (GO:0070486)4.16332091
46regulation of synapse structural plasticity (GO:0051823)4.13036914
47neuronal action potential propagation (GO:0019227)4.07822194
48* layer formation in cerebral cortex (GO:0021819)4.04316845
49glutamate receptor signaling pathway (GO:0007215)3.94138240
50neuromuscular process controlling posture (GO:0050884)3.92867549
51detection of external biotic stimulus (GO:0098581)3.91931945
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.83814065
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83333396
54neurotransmitter transport (GO:0006836)3.82899946
55detection of molecule of bacterial origin (GO:0032490)3.80943299
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.80647963
57activation of protein kinase A activity (GO:0034199)3.80380624
58response to host immune response (GO:0052572)3.77033193
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.77033193
60response to host (GO:0075136)3.76136804
61response to host defenses (GO:0052200)3.76136804
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.76136804
63regulation of interferon-beta biosynthetic process (GO:0045357)3.74888166
64synaptic transmission, glutamatergic (GO:0035249)3.71503457
65regulation of leukocyte degranulation (GO:0043300)3.68402064
66regulation of mast cell degranulation (GO:0043304)3.65616029
67long-term memory (GO:0007616)3.64215850
68neutrophil activation (GO:0042119)3.64073171
69regulation of myeloid leukocyte mediated immunity (GO:0002886)3.63270357
70regulation of neurotransmitter levels (GO:0001505)3.62184920
71neuromuscular process controlling balance (GO:0050885)3.60552939
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59605854
73neuron recognition (GO:0008038)3.58183287
74regulation of T-helper 2 cell differentiation (GO:0045628)3.57225113
75positive regulation of membrane potential (GO:0045838)3.53538605
76respiratory burst (GO:0045730)3.50328891
77cellular extravasation (GO:0045123)3.49511458
78neuron-neuron synaptic transmission (GO:0007270)3.49457885
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.46697463
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46373225
81positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45443302
82leukocyte migration involved in inflammatory response (GO:0002523)3.45362826
83regulation of B cell receptor signaling pathway (GO:0050855)3.44390931
84prepulse inhibition (GO:0060134)3.44219603
85neurotransmitter-gated ion channel clustering (GO:0072578)3.44155634
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44146396
87gamma-aminobutyric acid signaling pathway (GO:0007214)3.43720717
88negative regulation of interleukin-12 production (GO:0032695)3.43273919
89negative regulation of lymphocyte mediated immunity (GO:0002707)3.42440947
90alanine transport (GO:0032328)3.42290385
91response to interleukin-15 (GO:0070672)3.42176243
92positive regulation of Cdc42 GTPase activity (GO:0043089)3.41457617
93immunoglobulin mediated immune response (GO:0016064)3.40143090
94cerebellar Purkinje cell layer development (GO:0021680)3.39520081
95detection of biotic stimulus (GO:0009595)3.39269973
96transmission of nerve impulse (GO:0019226)3.38232143
97negative regulation of leukocyte mediated immunity (GO:0002704)3.34057181
98regulation of postsynaptic membrane potential (GO:0060078)3.33246180
99mating behavior (GO:0007617)3.32688937
100granulocyte activation (GO:0036230)3.32430901
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30429240
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29913707
103axonal fasciculation (GO:0007413)3.29330873
104regulation of synaptic plasticity (GO:0048167)3.28867107
105glycine transport (GO:0015816)3.28850259
106regulation of regulated secretory pathway (GO:1903305)3.27242810
107response to auditory stimulus (GO:0010996)3.26554507
108negative regulation of phagocytosis (GO:0050765)3.26334578
109positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.26186657
110regulation of mast cell activation involved in immune response (GO:0033006)3.25321461
111positive regulation of synapse maturation (GO:0090129)3.24680913
112cell communication by electrical coupling (GO:0010644)3.24314951
113cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24291685
114lipopolysaccharide-mediated signaling pathway (GO:0031663)3.22410189
115response to muramyl dipeptide (GO:0032495)3.22243950
116regulation of vesicle fusion (GO:0031338)3.22062443
117response to histamine (GO:0034776)3.21197615
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20870205
119regulation of dendritic spine morphogenesis (GO:0061001)3.20433378
120regulation of synaptic transmission, glutamatergic (GO:0051966)3.20034482
121auditory behavior (GO:0031223)3.19330640
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18774885
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15559726
124synaptic vesicle endocytosis (GO:0048488)3.14242581
125positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13440350
126regulation of gamma-delta T cell activation (GO:0046643)3.13115340
127germinal center formation (GO:0002467)3.11608260
128dendrite morphogenesis (GO:0048813)3.11145825
129cerebellar Purkinje cell differentiation (GO:0021702)3.11010496
130vesicle transport along microtubule (GO:0047496)3.10486997
131neuronal ion channel clustering (GO:0045161)3.09364863
132social behavior (GO:0035176)3.07802993
133intraspecies interaction between organisms (GO:0051703)3.07802993
134postsynaptic membrane organization (GO:0001941)3.07359644
135negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07288179
136myeloid cell activation involved in immune response (GO:0002275)3.07269510
137regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07182678
138regulation of ARF protein signal transduction (GO:0032012)3.04788524
139regulation of neurotransmitter secretion (GO:0046928)3.03952646
140regulation of glutamate secretion (GO:0014048)2.98952227
141macrophage activation (GO:0042116)2.96712042
142long-term synaptic potentiation (GO:0060291)2.96205488
143cellular response to type I interferon (GO:0071357)2.94751136
144type I interferon signaling pathway (GO:0060337)2.94751136
145positive regulation of dendritic spine development (GO:0060999)2.94185230
146negative regulation of type 2 immune response (GO:0002829)2.93998652
147response to type I interferon (GO:0034340)2.93485039
148L-amino acid import (GO:0043092)2.93005506
149regulation of clathrin-mediated endocytosis (GO:2000369)2.91428168
150positive regulation of B cell differentiation (GO:0045579)2.90997646
151neuromuscular process (GO:0050905)2.90721419
152negative regulation of microtubule polymerization (GO:0031115)2.90215256
153cellular sodium ion homeostasis (GO:0006883)2.88769673
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88637414
155antigen processing and presentation via MHC class Ib (GO:0002475)2.88125619
156regulation of B cell differentiation (GO:0045577)2.87991176
157cellular response to interleukin-15 (GO:0071350)2.87524705
158regulation of synaptic transmission (GO:0050804)2.86005326
159synapse assembly (GO:0007416)2.85650580
160regulation of neurotransmitter transport (GO:0051588)2.85036510
161positive regulation of synaptic transmission (GO:0050806)2.84825983
162pentose-phosphate shunt (GO:0006098)2.84776394
163regulation of gamma-delta T cell differentiation (GO:0045586)2.83277861
164learning (GO:0007612)2.80778863
165membrane hyperpolarization (GO:0060081)2.80594635
166organelle transport along microtubule (GO:0072384)2.80377700
167neutrophil mediated immunity (GO:0002446)2.80341374
168cell migration in hindbrain (GO:0021535)2.80174967
169positive regulation of regulated secretory pathway (GO:1903307)2.79826007
170membrane depolarization (GO:0051899)2.79646036
171potassium ion import (GO:0010107)2.79490963
172leukocyte degranulation (GO:0043299)2.79220049
173regulation of macrophage cytokine production (GO:0010935)2.75766555
174regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72472667
175negative regulation of cytokine production involved in immune response (GO:0002719)2.72333306
176negative regulation of interleukin-6 production (GO:0032715)2.71340870
177protein localization to endosome (GO:0036010)2.67460915
178microglial cell activation (GO:0001774)2.66560269
179B cell receptor signaling pathway (GO:0050853)2.66067666
180negative regulation of toll-like receptor signaling pathway (GO:0034122)2.65446659
181regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.62488809
182regulation of necroptotic process (GO:0060544)2.60496914
183regulation of superoxide anion generation (GO:0032928)2.60197545
184regulation of type 2 immune response (GO:0002828)2.59789843
185modulation by virus of host process (GO:0019054)2.58175296
186production of molecular mediator involved in inflammatory response (GO:0002532)2.57262690
187negative regulation of innate immune response (GO:0045824)2.56526127
188regulation of mast cell activation (GO:0033003)2.55926548
189response to interferon-alpha (GO:0035455)2.55548112
190positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.54916196
191negative regulation of T-helper cell differentiation (GO:0045623)2.54561786
192negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.54561786
193positive regulation of mast cell activation (GO:0033005)2.54222544
194B cell mediated immunity (GO:0019724)2.53839141
195negative regulation of T cell mediated immunity (GO:0002710)2.53649911
196modulation by symbiont of host cellular process (GO:0044068)2.52999717
197negative regulation of glycoprotein biosynthetic process (GO:0010561)2.51681190
198defense response to protozoan (GO:0042832)2.51335099
1993-UTR-mediated mRNA stabilization (GO:0070935)2.51106439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89774918
2VDR_21846776_ChIP-Seq_THP-1_Human3.25584579
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15382402
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14690603
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06125577
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.97061443
7REST_21632747_ChIP-Seq_MESCs_Mouse2.91979275
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.90957787
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.88737034
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79684876
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79684876
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75049852
13DROSHA_22980978_ChIP-Seq_HELA_Human2.74785309
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.69759802
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.68891226
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.65813731
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64700647
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.61542196
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.57729495
20MYC_22102868_ChIP-Seq_BL_Human2.57077261
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56265438
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53205223
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.51513177
24GBX2_23144817_ChIP-Seq_PC3_Human2.50011227
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.49578860
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.48036592
27* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47098151
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.45817598
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43795986
30EZH2_27304074_Chip-Seq_ESCs_Mouse2.42803030
31VDR_24763502_ChIP-Seq_THP-1_Human2.41635814
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.33283708
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.30007206
34TCF7_22412390_ChIP-Seq_EML_Mouse2.27615182
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26242923
36EED_16625203_ChIP-ChIP_MESCs_Mouse2.17547445
37EGR1_19374776_ChIP-ChIP_THP-1_Human2.16934153
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16736058
39RNF2_27304074_Chip-Seq_ESCs_Mouse2.16094250
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12771063
41ERG_21242973_ChIP-ChIP_JURKAT_Human2.09289921
42MAF_26560356_Chip-Seq_TH1_Human2.01978936
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.99203973
44RACK7_27058665_Chip-Seq_MCF-7_Human1.95620445
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94560430
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92621409
47* SPI1_23127762_ChIP-Seq_K562_Human1.91052531
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90867710
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.89088543
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87858020
51UTX_26944678_Chip-Seq_JUKART_Human1.87571536
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.86385784
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86298169
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82341161
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81647755
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81054303
57SPI1_23547873_ChIP-Seq_NB4_Human1.78754728
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78481037
59SCL_19346495_ChIP-Seq_HPC-7_Human1.75857272
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72349474
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.70559494
62MAF_26560356_Chip-Seq_TH2_Human1.65293842
63AR_21572438_ChIP-Seq_LNCaP_Human1.64953324
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64020683
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56738746
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56648503
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55260765
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.54942401
69KDM2B_26808549_Chip-Seq_K562_Human1.54839833
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52517734
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51786546
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50118392
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49634241
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48944505
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48473146
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48017132
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47785886
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.47292125
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46596275
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.45166568
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44295700
82* P68_20966046_ChIP-Seq_HELA_Human1.43829536
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.41768576
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41522162
85ZNF274_21170338_ChIP-Seq_K562_Hela1.41374856
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34719382
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34640952
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34044611
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32117823
90* LXR_22292898_ChIP-Seq_THP-1_Human1.31359955
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30562901
92* BCOR_27268052_Chip-Seq_Bcells_Human1.29433860
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29418850
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.29367022
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29264107
96NCOR1_26117541_ChIP-Seq_K562_Human1.27887594
97* BCL6_27268052_Chip-Seq_Bcells_Human1.27773985
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27624741
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26499553
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26241171
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25897194
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25488258
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25223546
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24645738
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24178680
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23756064
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23621831
108* ELF1_20517297_ChIP-Seq_JURKAT_Human1.22375626
109TAF15_26573619_Chip-Seq_HEK293_Human1.22259437
110EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21960929
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21821838
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21775042
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21330637
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20895714
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19108884
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18723510
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18443915
118MYB_26560356_Chip-Seq_TH1_Human1.18392353
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.17465715
120ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16165401
121GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15809307
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15804537
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15057880
124AR_19668381_ChIP-Seq_PC3_Human1.15037248
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13683852
126TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13439652
127SMAD4_21799915_ChIP-Seq_A2780_Human1.13393072
128GATA1_19941826_ChIP-Seq_K562_Human1.13051013
129MYB_26560356_Chip-Seq_TH2_Human1.13023136
130RUNX_20019798_ChIP-Seq_JUKART_Human1.10710184
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10653947
132CTCF_27219007_Chip-Seq_Bcells_Human1.10336647
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09955138
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09201959
135TET1_21490601_ChIP-Seq_MESCs_Mouse1.08955551
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08939724
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06994716
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06037873
139RING1B_27294783_Chip-Seq_NPCs_Mouse1.05559975
140P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05289418
141STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04888951
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03654609
143KDM2B_26808549_Chip-Seq_DND41_Human1.03074841
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02050811
145KDM2B_26808549_Chip-Seq_JURKAT_Human1.01850779
146ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01723202
147CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01568970
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99994020
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97343162
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96189381
151P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95501605
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94791786
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94270513
154SMC4_20622854_ChIP-Seq_HELA_Human0.93932970
155SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92392420
156AR_25329375_ChIP-Seq_VCAP_Human0.91775523
157SMAD_19615063_ChIP-ChIP_OVARY_Human0.91612019
158RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91107947
159TP53_20018659_ChIP-ChIP_R1E_Mouse0.90551764
160ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90290874
161OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89617505
162DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89047659
163SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88813572
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88144468
165RXR_22108803_ChIP-Seq_LS180_Human0.87952563
166SMAD3_21741376_ChIP-Seq_ESCs_Human0.86543476
167MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85575324
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.84372148
169MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83264070
170RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83191683
171SMAD3_21741376_ChIP-Seq_EPCs_Human0.82568440
172P300_19829295_ChIP-Seq_ESCs_Human0.80672564
173ARNT_22903824_ChIP-Seq_MCF-7_Human0.80539896
174YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79767316
175KLF4_19829295_ChIP-Seq_ESCs_Human0.79290615
176CREB1_26743006_Chip-Seq_LNCaP_Human0.79289555
177ESR2_21235772_ChIP-Seq_MCF-7_Human0.78885853
178STAT3_23295773_ChIP-Seq_U87_Human0.78248820
179ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77474902
180AHR_22903824_ChIP-Seq_MCF-7_Human0.76927722
181SMAD3_21741376_ChIP-Seq_HESCs_Human0.74691454
182TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74309918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.60751901
2MP0003880_abnormal_central_pattern4.57587590
3MP0003436_decreased_susceptibility_to4.53691777
4MP0003635_abnormal_synaptic_transmissio4.27914538
5MP0003724_increased_susceptibility_to3.88134299
6MP0009745_abnormal_behavioral_response3.44394106
7MP0002064_seizures3.41680485
8MP0004270_analgesia3.30760889
9MP0002063_abnormal_learning/memory/cond3.29873262
10MP0005423_abnormal_somatic_nervous3.17479407
11MP0009046_muscle_twitch3.09195699
12MP0001968_abnormal_touch/_nociception3.01147895
13MP0003191_abnormal_cellular_cholesterol3.00641248
14MP0002572_abnormal_emotion/affect_behav2.83825386
15MP0009278_abnormal_bone_marrow2.81107405
16MP0002419_abnormal_innate_immunity2.79777415
17MP0001835_abnormal_antigen_presentation2.74460273
18MP0003329_amyloid_beta_deposits2.72194745
19MP0003300_gastrointestinal_ulcer2.59317105
20MP0008260_abnormal_autophagy2.58554531
21MP0001501_abnormal_sleep_pattern2.58122932
22MP0001440_abnormal_grooming_behavior2.52923443
23MP0005025_abnormal_response_to2.47109635
24MP0001486_abnormal_startle_reflex2.43237671
25MP0003705_abnormal_hypodermis_morpholog2.41433549
26MP0002272_abnormal_nervous_system2.39407656
27MP0002822_catalepsy2.34279014
28MP0002734_abnormal_mechanical_nocicepti2.34068379
29MP0005451_abnormal_body_composition2.32475952
30MP0004858_abnormal_nervous_system2.31713450
31MP0002733_abnormal_thermal_nociception2.28212671
32MP0001533_abnormal_skeleton_physiology2.26132270
33MP0005000_abnormal_immune_tolerance2.23102304
34MP0002736_abnormal_nociception_after2.20679705
35MP0005464_abnormal_platelet_physiology2.18614701
36MP0000685_abnormal_immune_system2.15772650
37MP0002396_abnormal_hematopoietic_system2.15514737
38MP0002132_abnormal_respiratory_system2.12685920
39MP0002909_abnormal_adrenal_gland2.11122891
40MP0001970_abnormal_pain_threshold2.07792456
41MP0001790_abnormal_immune_system2.02174705
42MP0005387_immune_system_phenotype2.02174705
43MP0002420_abnormal_adaptive_immunity2.02111185
44MP0001819_abnormal_immune_cell2.01087139
45MP0009785_altered_susceptibility_to1.98313451
46MP0002723_abnormal_immune_serum1.96558543
47MP0003122_maternal_imprinting1.93405032
48MP0001800_abnormal_humoral_immune1.91402890
49MP0006276_abnormal_autonomic_nervous1.91110575
50MP0004947_skin_inflammation1.89178260
51MP0002452_abnormal_antigen_presenting1.87346066
52MP0002735_abnormal_chemical_nociception1.84598590
53MP0008569_lethality_at_weaning1.84124465
54MP0008961_abnormal_basal_metabolism1.84035654
55MP0002148_abnormal_hypersensitivity_rea1.82208962
56MP0002067_abnormal_sensory_capabilities1.81662175
57MP0009780_abnormal_chondrocyte_physiolo1.79082841
58MP0006082_CNS_inflammation1.75839839
59MP0004811_abnormal_neuron_physiology1.72004713
60MP0002557_abnormal_social/conspecific_i1.71393815
61MP0003566_abnormal_cell_adhesion1.70088047
62MP0000858_altered_metastatic_potential1.69402611
63MP0003828_pulmonary_edema1.66995052
64MP0004924_abnormal_behavior1.66807656
65MP0005386_behavior/neurological_phenoty1.66807656
66MP0001545_abnormal_hematopoietic_system1.62797129
67MP0005397_hematopoietic_system_phenotyp1.62797129
68MP0010155_abnormal_intestine_physiology1.61429844
69MP0000465_gastrointestinal_hemorrhage1.61253702
70MP0003866_abnormal_defecation1.58670544
71MP0002184_abnormal_innervation1.58603797
72MP0002398_abnormal_bone_marrow1.58388445
73MP0002405_respiratory_system_inflammati1.57859115
74MP0003172_abnormal_lysosome_physiology1.56095643
75MP0000604_amyloidosis1.52102089
76MP0000716_abnormal_immune_system1.51833887
77MP0001529_abnormal_vocalization1.51712551
78MP0003763_abnormal_thymus_physiology1.50371259
79MP0000778_abnormal_nervous_system1.49867470
80MP0000955_abnormal_spinal_cord1.49449455
81MP0004142_abnormal_muscle_tone1.49273878
82MP0003879_abnormal_hair_cell1.47902332
83MP0003633_abnormal_nervous_system1.45101326
84MP0005671_abnormal_response_to1.44359153
85MP0001502_abnormal_circadian_rhythm1.42032990
86MP0002066_abnormal_motor_capabilities/c1.41059380
87MP0003283_abnormal_digestive_organ1.40952201
88MP0005645_abnormal_hypothalamus_physiol1.39447075
89MP0001845_abnormal_inflammatory_respons1.37126719
90MP0003075_altered_response_to1.34664005
91MP0004885_abnormal_endolymph1.33546679
92MP0001905_abnormal_dopamine_level1.32898184
93MP0003690_abnormal_glial_cell1.32897104
94MP0002998_abnormal_bone_remodeling1.32089447
95MP0002722_abnormal_immune_system1.31542530
96MP0009333_abnormal_splenocyte_physiolog1.30645656
97MP0002429_abnormal_blood_cell1.29638978
98MP0002882_abnormal_neuron_morphology1.29121392
99MP0005390_skeleton_phenotype1.28080902
100MP0008469_abnormal_protein_level1.27547456
101MP0005646_abnormal_pituitary_gland1.25936917
102MP0001849_ear_inflammation1.25206410
103MP0004808_abnormal_hematopoietic_stem1.24622596
104MP0005076_abnormal_cell_differentiation1.24207361
105MP0009840_abnormal_foam_cell1.21062484
106MP0000678_abnormal_parathyroid_gland1.20342197
107MP0000703_abnormal_thymus_morphology1.18897806
108MP0000490_abnormal_crypts_of1.18719558
109MP0001851_eye_inflammation1.18663958
110MP0000689_abnormal_spleen_morphology1.18507722
111MP0003631_nervous_system_phenotype1.15494538
112MP0008874_decreased_physiological_sensi1.14887663
113MP0003634_abnormal_glial_cell1.11460142
114MP0008872_abnormal_physiological_respon1.09511703
115MP0002877_abnormal_melanocyte_morpholog1.09301806
116MP0000013_abnormal_adipose_tissue1.07952449
117MP0009764_decreased_sensitivity_to1.07328474
118MP0002152_abnormal_brain_morphology1.06442256
119MP0005535_abnormal_body_temperature1.05954911
120MP0001984_abnormal_olfaction1.03631972
121MP0003091_abnormal_cell_migration1.01131461
122MP0002069_abnormal_eating/drinking_beha1.00940947
123MP0005164_abnormal_response_to1.00153269
124MP0008004_abnormal_stomach_pH0.99547899
125MP0004883_abnormal_blood_vessel0.98481455
126MP0000920_abnormal_myelination0.98125990
127MP0003303_peritoneal_inflammation0.97678366
128MP0004381_abnormal_hair_follicle0.94509030
129MP0005023_abnormal_wound_healing0.94436415
130MP0002837_dystrophic_cardiac_calcinosis0.93801888
131MP0003448_altered_tumor_morphology0.93696233
132MP0001873_stomach_inflammation0.93579232
133MP0003279_aneurysm0.93534564
134MP0001958_emphysema0.93510000
135MP0003453_abnormal_keratinocyte_physiol0.93202475
136MP0003787_abnormal_imprinting0.92996411
137MP0003806_abnormal_nucleotide_metabolis0.92301789
138MP0005310_abnormal_salivary_gland0.91411099
139MP0002229_neurodegeneration0.87566174
140MP0005623_abnormal_meninges_morphology0.85725809
141MP0003183_abnormal_peptide_metabolism0.85674233
142MP0000751_myopathy0.85429111
143MP0000343_altered_response_to0.84014662
144MP0002090_abnormal_vision0.83962049
145MP0003123_paternal_imprinting0.82564856
146MP0002277_abnormal_respiratory_mucosa0.80983391
147MP0004264_abnormal_extraembryonic_tissu0.80535305
148MP0005167_abnormal_blood-brain_barrier0.80311287
149MP0003632_abnormal_nervous_system0.79377049
150MP0001663_abnormal_digestive_system0.79240388
151MP0001177_atelectasis0.79026803
152MP0003795_abnormal_bone_structure0.78114564
153MP0005409_darkened_coat_color0.77990354
154MP0004510_myositis0.74563701
155MP0003045_fibrosis0.73477229
156MP0010234_abnormal_vibrissa_follicle0.72512449
157MP0001853_heart_inflammation0.72425877
158MP0002796_impaired_skin_barrier0.72146248
159MP0005083_abnormal_biliary_tract0.71592909
160MP0004185_abnormal_adipocyte_glucose0.68323179
161MP0005166_decreased_susceptibility_to0.66996195
162MP0000681_abnormal_thyroid_gland0.66927368
163MP0009931_abnormal_skin_appearance0.63841852
164MP0009763_increased_sensitivity_to0.63726611
165MP0010386_abnormal_urinary_bladder0.63225135
166MP0005621_abnormal_cell_physiology0.62983206
167MP0002089_abnormal_postnatal_growth/wei0.62139777
168MP0001664_abnormal_digestion0.62063108
169MP0004085_abnormal_heartbeat0.61915243
170MP0000747_muscle_weakness0.60939968
171MP0004742_abnormal_vestibular_system0.60549172
172MP0000750_abnormal_muscle_regeneration0.59825317
173MP0005448_abnormal_energy_balance0.59394860
174MP0000639_abnormal_adrenal_gland0.59141553
175MP0005058_abnormal_lysosome_morphology0.58982758
176MP0000631_abnormal_neuroendocrine_gland0.58845007
177MP0003137_abnormal_impulse_conducting0.58839157
178MP0004145_abnormal_muscle_electrophysio0.58096264
179MP0001943_abnormal_respiration0.57712250
180MP0005551_abnormal_eye_electrophysiolog0.53737324
181MP0000569_abnormal_digit_pigmentation0.52417771
182MP0001963_abnormal_hearing_physiology0.52406495
183MP0002752_abnormal_somatic_nervous0.51288705
184MP0003956_abnormal_body_size0.51023950
185MP0010769_abnormal_survival0.50346542
186MP0001299_abnormal_eye_distance/0.48500996
187MP0010770_preweaning_lethality0.47821380
188MP0002082_postnatal_lethality0.47821380

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.80653131
2Myokymia (HP:0002411)6.30342929
3Focal seizures (HP:0007359)5.62135582
4Visual hallucinations (HP:0002367)5.57325955
5Eczematoid dermatitis (HP:0000976)5.38675492
6Myositis (HP:0100614)4.75604739
7Recurrent abscess formation (HP:0002722)4.65295097
8Supranuclear gaze palsy (HP:0000605)4.54252760
9Abnormality of macrophages (HP:0004311)4.45274734
10Orchitis (HP:0100796)4.28263733
11Recurrent bacterial skin infections (HP:0005406)4.22604315
12Absence seizures (HP:0002121)4.13449567
13Atonic seizures (HP:0010819)4.11965035
14Elevated erythrocyte sedimentation rate (HP:0003565)4.02006713
15Generalized tonic-clonic seizures (HP:0002069)3.89942910
16Epileptic encephalopathy (HP:0200134)3.84832601
17Dialeptic seizures (HP:0011146)3.80878594
18Neurofibrillary tangles (HP:0002185)3.76997805
19Papilledema (HP:0001085)3.74419537
20Chronic obstructive pulmonary disease (HP:0006510)3.67638898
21Obstructive lung disease (HP:0006536)3.67638898
22Cellulitis (HP:0100658)3.65912944
23Cerebral inclusion bodies (HP:0100314)3.65860247
24Mutism (HP:0002300)3.65685901
25Progressive cerebellar ataxia (HP:0002073)3.64047097
26Abnormal eating behavior (HP:0100738)3.61432119
27Action tremor (HP:0002345)3.53121927
28Recurrent gram-negative bacterial infections (HP:0005420)3.52083366
29Depression (HP:0000716)3.48507481
30Febrile seizures (HP:0002373)3.47793782
31Increased IgE level (HP:0003212)3.47591584
32Ankle clonus (HP:0011448)3.47553549
33Retrobulbar optic neuritis (HP:0100654)3.35135486
34Optic neuritis (HP:0100653)3.35135486
35Stomatitis (HP:0010280)3.31880613
36Postural instability (HP:0002172)3.30913986
37Mediastinal lymphadenopathy (HP:0100721)3.20555846
38Hemiplegia (HP:0002301)3.18132018
39Peritonitis (HP:0002586)3.10092432
40Recurrent fungal infections (HP:0002841)3.07303145
41Truncal ataxia (HP:0002078)3.06495128
42Abnormality of binocular vision (HP:0011514)3.05492525
43Diplopia (HP:0000651)3.05492525
44Impaired vibration sensation in the lower limbs (HP:0002166)3.03938988
45Dysdiadochokinesis (HP:0002075)3.02715684
46Polyphagia (HP:0002591)3.02585221
47Urticaria (HP:0001025)3.01557919
48Anxiety (HP:0000739)3.00505009
49Meningitis (HP:0001287)2.96513005
50Gingivitis (HP:0000230)2.95883965
51Gastrointestinal infarctions (HP:0005244)2.94882147
52Dysmetria (HP:0001310)2.94801615
53Abnormal social behavior (HP:0012433)2.94746034
54Impaired social interactions (HP:0000735)2.94746034
55Hypochromic microcytic anemia (HP:0004840)2.93943601
56Hemiparesis (HP:0001269)2.93474283
57Poor eye contact (HP:0000817)2.91145935
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.86954077
59Prolonged bleeding time (HP:0003010)2.85142312
60Urinary bladder sphincter dysfunction (HP:0002839)2.83527534
61Recurrent skin infections (HP:0001581)2.82001045
62Status epilepticus (HP:0002133)2.80662745
63Spontaneous hematomas (HP:0007420)2.77170571
64Progressive inability to walk (HP:0002505)2.74433892
65Abnormality of the lower motor neuron (HP:0002366)2.73995480
66Urinary urgency (HP:0000012)2.73283541
67Hypochromic anemia (HP:0001931)2.72961195
68Episodic fever (HP:0001954)2.71317458
69Amyloidosis (HP:0011034)2.69004783
70Neuronal loss in central nervous system (HP:0002529)2.68657999
71Chest pain (HP:0100749)2.66232681
72Amblyopia (HP:0000646)2.66115413
73Bradykinesia (HP:0002067)2.65247511
74Torticollis (HP:0000473)2.64981413
75Agitation (HP:0000713)2.64341867
76Broad-based gait (HP:0002136)2.62074491
77Genetic anticipation (HP:0003743)2.60760184
78Spastic gait (HP:0002064)2.58694165
79Broad face (HP:0000283)2.55812034
80Megalencephaly (HP:0001355)2.54660400
81Intention tremor (HP:0002080)2.53169553
82Petechiae (HP:0000967)2.50662959
83Epistaxis (HP:0000421)2.45657426
84Focal dystonia (HP:0004373)2.43650536
85Encephalitis (HP:0002383)2.43428862
86Amyotrophic lateral sclerosis (HP:0007354)2.43130604
87Chronic mucocutaneous candidiasis (HP:0002728)2.41090788
88Recurrent cutaneous fungal infections (HP:0011370)2.41090788
89Impaired smooth pursuit (HP:0007772)2.39636258
90Insomnia (HP:0100785)2.38815114
91Rapidly progressive (HP:0003678)2.36808101
92Keratoconjunctivitis sicca (HP:0001097)2.32474942
93Psychosis (HP:0000709)2.32466121
94Stereotypic behavior (HP:0000733)2.31683943
95Gastrointestinal inflammation (HP:0004386)2.30529205
96Limb dystonia (HP:0002451)2.29609043
97Failure to thrive in infancy (HP:0001531)2.27076275
98Craniofacial dystonia (HP:0012179)2.27063392
99Loss of speech (HP:0002371)2.26398053
100Drooling (HP:0002307)2.25560363
101Excessive salivation (HP:0003781)2.25560363
102Vasculitis (HP:0002633)2.25425159
103Polygenic inheritance (HP:0010982)2.24402155
104Rigidity (HP:0002063)2.24068015
105Generalized myoclonic seizures (HP:0002123)2.23399669
106Hepatosplenomegaly (HP:0001433)2.22371992
107Scanning speech (HP:0002168)2.21753932
108Abnormality of the peritoneum (HP:0002585)2.19973721
109Interstitial pulmonary disease (HP:0006530)2.19695940
110Gaze-evoked nystagmus (HP:0000640)2.19128916
111Arterial thrombosis (HP:0004420)2.18960852
112Ankyloglossia (HP:0010296)2.18431951
113Gingival bleeding (HP:0000225)2.17666673
114Apathy (HP:0000741)2.16843409
115Hypoventilation (HP:0002791)2.16528018
116Peripheral hypomyelination (HP:0007182)2.15066672
117Slow saccadic eye movements (HP:0000514)2.14638883
118Abnormality of glycolipid metabolism (HP:0010969)2.13774327
119Abnormality of liposaccharide metabolism (HP:0010968)2.13774327
120Abnormality of glycosphingolipid metabolism (HP:0004343)2.13774327
121Increased neuronal autofluorescent lipopigment (HP:0002074)2.13453851
122Abnormality of ocular smooth pursuit (HP:0000617)2.12423238
123Inflammation of the large intestine (HP:0002037)2.10953427
124Dysostosis multiplex (HP:0000943)2.09876347
125Annular pancreas (HP:0001734)2.09748013
126Neoplasm of the heart (HP:0100544)2.09655292
127Pustule (HP:0200039)2.09455535
128Global brain atrophy (HP:0002283)2.09111970
129Ventricular fibrillation (HP:0001663)2.08883066
130Pheochromocytoma (HP:0002666)2.08869414
131Insidious onset (HP:0003587)2.08630447
132Termporal pattern (HP:0011008)2.08630447
133Metaphyseal cupping (HP:0003021)2.07758376
134Increased connective tissue (HP:0009025)2.04887924
135Abnormal platelet volume (HP:0011876)2.04457696
136Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04159883
137Osteomyelitis (HP:0002754)2.04106730
138Lower limb muscle weakness (HP:0007340)2.02565997
139Dysmetric saccades (HP:0000641)2.01786173
140Pointed chin (HP:0000307)2.01221657
141Keratoconjunctivitis (HP:0001096)2.00210841
142Polycythemia (HP:0001901)2.00172965
143Increased serum ferritin (HP:0003281)1.99053076
144Sepsis (HP:0100806)1.98737996
145Hypertensive crisis (HP:0100735)1.98551125
146Abnormality of the corticospinal tract (HP:0002492)1.98074631
147Clonus (HP:0002169)1.97836002
148Recurrent viral infections (HP:0004429)1.96351406
149Microcytic anemia (HP:0001935)1.94903718
150EEG with generalized epileptiform discharges (HP:0011198)1.94824865
151Resting tremor (HP:0002322)1.94604085
152Hypergammaglobulinemia (HP:0010702)1.94497248
153Diminished motivation (HP:0000745)1.94111002
154Dementia (HP:0000726)1.93798823
155Epileptiform EEG discharges (HP:0011182)1.93793312
156Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92511200
157Distal lower limb muscle weakness (HP:0009053)1.92213470
158Skin ulcer (HP:0200042)1.91720198
159Granulocytopenia (HP:0001913)1.91232697
160Anorexia (HP:0002039)1.90367828
161Hypercortisolism (HP:0001578)1.90101933
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.88569325
163Hypsarrhythmia (HP:0002521)1.88132098
164Vertebral compression fractures (HP:0002953)1.87614174
165Abnormality of saccadic eye movements (HP:0000570)1.87346637
166Segmental peripheral demyelination/remyelination (HP:0003481)1.87169417
167Impaired vibratory sensation (HP:0002495)1.86069438
168Purpura (HP:0000979)1.85248662
169Hemorrhage of the eye (HP:0011885)1.85206297
170Pulmonary infiltrates (HP:0002113)1.84809814
171Protrusio acetabuli (HP:0003179)1.84752685
172Premature loss of primary teeth (HP:0006323)1.84612872
173Dilatation of the ascending aorta (HP:0005111)1.84586207
174Hypertriglyceridemia (HP:0002155)1.84464365
175Abnormality of the pericardium (HP:0001697)1.84401765
176Increased IgM level (HP:0003496)1.83749757
177Delusions (HP:0000746)1.83413242
178Increased cerebral lipofuscin (HP:0011813)1.82898314
179Hemoptysis (HP:0002105)1.82885507
180Achilles tendon contracture (HP:0001771)1.82821777
181Glomerulopathy (HP:0100820)1.82412027
182Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82215603
183Abnormality of polysaccharide metabolism (HP:0011012)1.82215603
184Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82215603
185Bronchomalacia (HP:0002780)1.81803486
186Gait ataxia (HP:0002066)1.81480739
187Acne (HP:0001061)1.81288394
188Inability to walk (HP:0002540)1.80512257
189Bruising susceptibility (HP:0000978)1.79978044
190Obstructive sleep apnea (HP:0002870)1.79880387
191Postural tremor (HP:0002174)1.79211439
192Pulmonary embolism (HP:0002204)1.76488215
193Hypermelanotic macule (HP:0001034)1.76311936
194Cervical subluxation (HP:0003308)1.75580241
195Easy fatigability (HP:0003388)1.72506802
196Cerebral aneurysm (HP:0004944)1.72133284
197Disproportionate tall stature (HP:0001519)1.71746970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.60655333
2ERN14.25582190
3NTRK34.15437592
4EPHA43.50083500
5MAP2K33.02991142
6MARK12.97592436
7MAP4K12.82856619
8MAP3K42.75524112
9MINK12.65379355
10IRAK42.55925884
11SMG12.49208675
12NTRK22.47384219
13MAP3K122.39274194
14KSR22.37712337
15EPHB12.34107127
16PAK62.27269270
17DAPK22.17987824
18NTRK12.16475854
19SIK12.14861728
20RIPK42.13995319
21MAP3K32.00596100
22MAP2K41.99014307
23TESK21.94732509
24CAMKK11.84295140
25TYK21.84091375
26PRKD31.77469025
27SIK21.77018464
28MAP2K71.74786658
29CSK1.66823299
30FES1.66476809
31ZAP701.58072509
32CDK51.55083689
33BLK1.55011052
34TAOK21.54551848
35TNIK1.53901977
36MAP3K131.53435380
37IRAK31.52922782
38PNCK1.50673937
39TBK11.49609063
40DAPK11.48486856
41UHMK11.47438604
42CDK191.46125216
43PRKD21.45826315
44JAK31.41935836
45ARAF1.41037836
46KSR11.40809936
47TYRO31.40736061
48PTK61.39585584
49LATS21.34422749
50GRK51.33405408
51MAP3K21.25347602
52BTK1.19673308
53HCK1.19271286
54STK381.17372704
55SIK31.15402129
56TAOK11.14872309
57PRKCG1.11001520
58PRKCH1.07882618
59EPHA21.06001355
60STK111.00595121
61ALK1.00192815
62IRAK21.00014876
63TESK10.98176060
64PAK40.97604285
65CDK150.96762853
66CDK180.96124692
67RET0.95326843
68LRRK20.95102229
69TNK20.93526545
70CDK140.93289537
71PAK30.90423590
72MAPK130.90045975
73CAMK10.89945756
74PKN20.89158447
75JAK20.88674476
76CDK120.88443405
77CDK11A0.87472412
78MAP3K140.87360073
79SCYL20.87326538
80PRKG20.86521111
81CAMK1G0.85452630
82TTN0.85433662
83CAMKK20.84813334
84IKBKE0.83606042
85CSF1R0.83570279
86FGR0.82534917
87PHKG10.82343900
88PHKG20.82343900
89KIT0.80572742
90MARK20.80536923
91CAMK2A0.79688953
92PRPF4B0.79688847
93SYK0.79591049
94RIPK10.74924997
95GRK60.74378297
96CSNK1G20.74163869
97RAF10.73920107
98JAK10.73817276
99TRIB30.72579480
100HIPK20.72006710
101PLK20.71762963
102MAP3K10.71756495
103LMTK20.71134110
104NME20.70786158
105STK100.70528480
106FGFR40.68111819
107MAP2K20.64690897
108LCK0.64231356
109MAP3K80.63866788
110MATK0.62461224
111PDPK10.62420329
112RPS6KC10.62106784
113RPS6KL10.62106784
114LYN0.61692484
115DYRK1B0.59566025
116PDK10.59351572
117MAP3K110.59201748
118KDR0.58737818
119CAMK2B0.58629938
120PTK2B0.57820868
121PRKCZ0.56331108
122FYN0.55941768
123SGK10.54130313
124IRAK10.53528451
125FGFR20.53429552
126ICK0.51320310
127MAPKAPK20.50185691
128YES10.50027138
129SGK4940.49791135
130SGK2230.49791135
131MAP3K70.48639280
132WNK30.47574343
133RPS6KA30.46904239
134SGK30.45162587
135RPS6KA60.44729397
136DAPK30.43593216
137BMX0.43428896
138OXSR10.43314025
139DYRK1A0.41688497
140MOS0.40754678
141PTK20.40695454
142IKBKB0.40643547
143ROCK20.39876463
144TGFBR20.39278369
145MAPK100.38773829
146CAMK2G0.36522917
147MAP3K60.35380288
148CDC42BPA0.35212518
149MAPK70.35207240
150CAMK40.34036970
151MAP3K50.33931569
152PRKD10.33624606
153GRK70.33239284
154PINK10.33212095
155SRC0.31248189
156RPS6KA20.30910994
157PRKCB0.30058360
158WNK10.29435245
159DMPK0.29254480
160MAPK120.28491483

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.60349920
2Synaptic vesicle cycle_Homo sapiens_hsa047213.23087164
3GABAergic synapse_Homo sapiens_hsa047272.75392685
4Osteoclast differentiation_Homo sapiens_hsa043802.58798579
5Leishmaniasis_Homo sapiens_hsa051402.46233671
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42482700
7Nitrogen metabolism_Homo sapiens_hsa009102.39634076
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39551794
9Long-term potentiation_Homo sapiens_hsa047202.38360118
10Acute myeloid leukemia_Homo sapiens_hsa052212.35985755
11Glutamatergic synapse_Homo sapiens_hsa047242.34217200
12Circadian entrainment_Homo sapiens_hsa047132.33223137
13Morphine addiction_Homo sapiens_hsa050322.33188563
14Olfactory transduction_Homo sapiens_hsa047402.33054158
15Amphetamine addiction_Homo sapiens_hsa050312.21659469
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12438666
17Dopaminergic synapse_Homo sapiens_hsa047282.03125342
18Salivary secretion_Homo sapiens_hsa049702.00731441
19B cell receptor signaling pathway_Homo sapiens_hsa046621.99447312
20Cocaine addiction_Homo sapiens_hsa050301.88945409
21Gastric acid secretion_Homo sapiens_hsa049711.84582679
22Other glycan degradation_Homo sapiens_hsa005111.83671245
23Insulin secretion_Homo sapiens_hsa049111.82580477
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76876031
25Tuberculosis_Homo sapiens_hsa051521.76679026
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74095550
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70983916
28Chronic myeloid leukemia_Homo sapiens_hsa052201.69649858
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68578043
30Cholinergic synapse_Homo sapiens_hsa047251.67659150
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67569419
32Staphylococcus aureus infection_Homo sapiens_hsa051501.57735783
33Malaria_Homo sapiens_hsa051441.56382581
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.55757845
35Long-term depression_Homo sapiens_hsa047301.55627941
36Renin secretion_Homo sapiens_hsa049241.54868869
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53872219
38Serotonergic synapse_Homo sapiens_hsa047261.48619265
39Pancreatic cancer_Homo sapiens_hsa052121.47523580
40Oxytocin signaling pathway_Homo sapiens_hsa049211.44613416
41Taste transduction_Homo sapiens_hsa047421.43708417
42Toxoplasmosis_Homo sapiens_hsa051451.41773430
43GnRH signaling pathway_Homo sapiens_hsa049121.41458026
44Shigellosis_Homo sapiens_hsa051311.40595835
45Collecting duct acid secretion_Homo sapiens_hsa049661.37509699
46Gap junction_Homo sapiens_hsa045401.35622942
47Measles_Homo sapiens_hsa051621.35464064
48Notch signaling pathway_Homo sapiens_hsa043301.30982714
49Hepatitis C_Homo sapiens_hsa051601.30040819
50Influenza A_Homo sapiens_hsa051641.29956508
51Calcium signaling pathway_Homo sapiens_hsa040201.28903558
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27690282
53Estrogen signaling pathway_Homo sapiens_hsa049151.25138165
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23367531
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23228365
56Salmonella infection_Homo sapiens_hsa051321.23177228
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22933809
58TNF signaling pathway_Homo sapiens_hsa046681.22098936
59African trypanosomiasis_Homo sapiens_hsa051431.21711857
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20448436
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20409458
62Hepatitis B_Homo sapiens_hsa051611.19195089
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18752371
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.17635671
65Pentose phosphate pathway_Homo sapiens_hsa000301.17023651
66Phagosome_Homo sapiens_hsa041451.14369267
67Graft-versus-host disease_Homo sapiens_hsa053321.12956218
68Allograft rejection_Homo sapiens_hsa053301.11715713
69Type II diabetes mellitus_Homo sapiens_hsa049301.10694889
70cAMP signaling pathway_Homo sapiens_hsa040241.10667704
71Glioma_Homo sapiens_hsa052141.10198551
72T cell receptor signaling pathway_Homo sapiens_hsa046601.08905044
73NF-kappa B signaling pathway_Homo sapiens_hsa040641.07229977
74Apoptosis_Homo sapiens_hsa042101.06839925
75Bladder cancer_Homo sapiens_hsa052191.06282229
76Amoebiasis_Homo sapiens_hsa051461.04600310
77Legionellosis_Homo sapiens_hsa051341.04276012
78Herpes simplex infection_Homo sapiens_hsa051681.03356797
79Viral myocarditis_Homo sapiens_hsa054161.02133378
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01338019
81Hematopoietic cell lineage_Homo sapiens_hsa046401.00573181
82Axon guidance_Homo sapiens_hsa043600.98964646
83Primary immunodeficiency_Homo sapiens_hsa053400.98380146
84Antigen processing and presentation_Homo sapiens_hsa046120.98197118
85Vibrio cholerae infection_Homo sapiens_hsa051100.97484426
86Autoimmune thyroid disease_Homo sapiens_hsa053200.97450649
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.94454816
88Melanogenesis_Homo sapiens_hsa049160.94296108
89ErbB signaling pathway_Homo sapiens_hsa040120.92533521
90Prolactin signaling pathway_Homo sapiens_hsa049170.92327828
91Bile secretion_Homo sapiens_hsa049760.91866228
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90283990
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.88844774
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88729780
95Dorso-ventral axis formation_Homo sapiens_hsa043200.88018674
96Pertussis_Homo sapiens_hsa051330.85904152
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84546535
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83513888
99Cardiac muscle contraction_Homo sapiens_hsa042600.82932415
100Thyroid cancer_Homo sapiens_hsa052160.82925236
101Thyroid hormone synthesis_Homo sapiens_hsa049180.81741830
102Prion diseases_Homo sapiens_hsa050200.78774843
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76636337
104VEGF signaling pathway_Homo sapiens_hsa043700.74640226
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74555720
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.74079507
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72156043
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72138325
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71336803
110Galactose metabolism_Homo sapiens_hsa000520.68384804
111Viral carcinogenesis_Homo sapiens_hsa052030.68096365
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.66909373
113Choline metabolism in cancer_Homo sapiens_hsa052310.66032465
114Pancreatic secretion_Homo sapiens_hsa049720.66004848
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.65742571
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.65403722
117HTLV-I infection_Homo sapiens_hsa051660.64198638
118Arginine biosynthesis_Homo sapiens_hsa002200.64153480
119MAPK signaling pathway_Homo sapiens_hsa040100.63765771
120Oocyte meiosis_Homo sapiens_hsa041140.62869768
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61704638
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61443159
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59294634
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59100924
125Epstein-Barr virus infection_Homo sapiens_hsa051690.58845540
126Proteoglycans in cancer_Homo sapiens_hsa052050.58481253
127HIF-1 signaling pathway_Homo sapiens_hsa040660.57197255
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57053296
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56685289
130Focal adhesion_Homo sapiens_hsa045100.56527776
131mTOR signaling pathway_Homo sapiens_hsa041500.56250130
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55903515
133Insulin resistance_Homo sapiens_hsa049310.55340896
134Endocytosis_Homo sapiens_hsa041440.54685317
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54566631
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53277032
137Rap1 signaling pathway_Homo sapiens_hsa040150.53005499
138Renal cell carcinoma_Homo sapiens_hsa052110.50200979
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49748516
140Dilated cardiomyopathy_Homo sapiens_hsa054140.49380374
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48032569
142Insulin signaling pathway_Homo sapiens_hsa049100.46570372
143Non-small cell lung cancer_Homo sapiens_hsa052230.45390030
144Glucagon signaling pathway_Homo sapiens_hsa049220.45386981
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44125790
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42539541
147Endometrial cancer_Homo sapiens_hsa052130.41113009
148Butanoate metabolism_Homo sapiens_hsa006500.41071105
149Ras signaling pathway_Homo sapiens_hsa040140.40788644
150Type I diabetes mellitus_Homo sapiens_hsa049400.38160279
151Fatty acid biosynthesis_Homo sapiens_hsa000610.37216226
152Inositol phosphate metabolism_Homo sapiens_hsa005620.36448241
153Chemokine signaling pathway_Homo sapiens_hsa040620.34811484
154Lysosome_Homo sapiens_hsa041420.32764427
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32719691
156Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30798038
157Platelet activation_Homo sapiens_hsa046110.30775118
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.29995856
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29662454
160Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28767341
161Colorectal cancer_Homo sapiens_hsa052100.28228482
162Alcoholism_Homo sapiens_hsa050340.25565136

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