MBTPS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.22019502
2COPI coating of Golgi vesicle (GO:0048205)4.22019502
3polarized epithelial cell differentiation (GO:0030859)4.06090531
4paraxial mesoderm development (GO:0048339)4.03244374
5regulation of translational fidelity (GO:0006450)3.99669548
6establishment of apical/basal cell polarity (GO:0035089)3.70663862
7skin morphogenesis (GO:0043589)3.67166105
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64758118
9protein heterotrimerization (GO:0070208)3.61712106
10regulation of posttranscriptional gene silencing (GO:0060147)3.59767030
11regulation of gene silencing by miRNA (GO:0060964)3.59767030
12regulation of gene silencing by RNA (GO:0060966)3.59767030
13desmosome organization (GO:0002934)3.54720078
14positive regulation of SMAD protein import into nucleus (GO:0060391)3.52848454
15regulation of hippo signaling (GO:0035330)3.49744394
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.47078672
17protein localization to endosome (GO:0036010)3.44950852
18hippo signaling (GO:0035329)3.34529425
19nuclear pore organization (GO:0006999)3.29085737
20peptidyl-lysine dimethylation (GO:0018027)3.27099952
21cell adhesion mediated by integrin (GO:0033627)3.27021047
22regulation of SMAD protein import into nucleus (GO:0060390)3.25698275
23DNA unwinding involved in DNA replication (GO:0006268)3.25451411
24heterochromatin organization (GO:0070828)3.24306335
25nuclear pore complex assembly (GO:0051292)3.24021254
26embryonic foregut morphogenesis (GO:0048617)3.23200217
27embryonic process involved in female pregnancy (GO:0060136)3.21804888
28pre-miRNA processing (GO:0031054)3.16475532
29COPII vesicle coating (GO:0048208)3.15316085
30glucocorticoid receptor signaling pathway (GO:0042921)3.12476136
31barbed-end actin filament capping (GO:0051016)3.08893451
32vesicle coating (GO:0006901)3.08371436
33epithelial cell differentiation involved in prostate gland development (GO:0060742)3.07011563
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.04702526
35regulation of extracellular matrix disassembly (GO:0010715)3.01442649
36regulation of glucose import in response to insulin stimulus (GO:2001273)3.01347245
37semaphorin-plexin signaling pathway (GO:0071526)3.00452257
38anterior/posterior axis specification, embryo (GO:0008595)2.97876680
39collagen fibril organization (GO:0030199)2.94414074
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.93965375
41insulin-like growth factor receptor signaling pathway (GO:0048009)2.92976414
42apoptotic cell clearance (GO:0043277)2.92380373
43* activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.92288570
44establishment or maintenance of monopolar cell polarity (GO:0061339)2.91724580
45establishment of monopolar cell polarity (GO:0061162)2.91724580
46dorsal/ventral axis specification (GO:0009950)2.91528070
47branching involved in mammary gland duct morphogenesis (GO:0060444)2.89858008
48negative regulation of cell size (GO:0045792)2.88956192
49adherens junction assembly (GO:0034333)2.88938616
50* positive regulation of nuclease activity (GO:0032075)2.86411289
51peptidyl-proline hydroxylation (GO:0019511)2.85450970
52mannose metabolic process (GO:0006013)2.84802542
53cell migration involved in sprouting angiogenesis (GO:0002042)2.82842630
54bone trabecula formation (GO:0060346)2.81503854
55maternal placenta development (GO:0001893)2.80767635
56endocardial cushion development (GO:0003197)2.80044210
57positive regulation of blood vessel endothelial cell migration (GO:0043536)2.77141249
58basement membrane organization (GO:0071711)2.76705780
59gastrulation with mouth forming second (GO:0001702)2.75711858
60histone H2A monoubiquitination (GO:0035518)2.74182588
61response to laminar fluid shear stress (GO:0034616)2.72254385
62epithelial cell-cell adhesion (GO:0090136)2.70187590
63outer ear morphogenesis (GO:0042473)2.68646639
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.68065180
65G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.67858290
66folic acid-containing compound biosynthetic process (GO:0009396)2.66695426
67membrane protein ectodomain proteolysis (GO:0006509)2.66505401
68* ER-nucleus signaling pathway (GO:0006984)2.65970651
69positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.65538272
70positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.65051740
71anatomical structure regression (GO:0060033)2.65007240
72protein retention in ER lumen (GO:0006621)2.64979184
73embryonic eye morphogenesis (GO:0048048)2.64339933
74positive regulation of Cdc42 GTPase activity (GO:0043089)2.64317214
75endodermal cell differentiation (GO:0035987)2.64049563
76negative regulation of chondrocyte differentiation (GO:0032331)2.63187528
77activation of Rac GTPase activity (GO:0032863)2.61304296
78positive regulation of extracellular matrix organization (GO:1903055)2.60841626
79regulation of fatty acid beta-oxidation (GO:0031998)2.59629555
80* regulation of nuclease activity (GO:0032069)2.59606180
81glomerular basement membrane development (GO:0032836)2.57888723
82ectodermal placode formation (GO:0060788)2.56960024
83negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.55387202
84cell-substrate junction assembly (GO:0007044)2.54882540
85establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.52070299
86protein localization to kinetochore (GO:0034501)2.52023717
87vascular endothelial growth factor signaling pathway (GO:0038084)2.51807738
88proline biosynthetic process (GO:0006561)2.51784761
89stress fiber assembly (GO:0043149)2.51702198
90negative regulation of fatty acid transport (GO:2000192)2.50286986
91mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.50139119
92RNA stabilization (GO:0043489)2.49431787
93mRNA stabilization (GO:0048255)2.49431787
94chromatin assembly (GO:0031497)2.48809225
95surfactant homeostasis (GO:0043129)2.48574596
96spliceosomal tri-snRNP complex assembly (GO:0000244)2.48569497
97regulation of histone H3-K27 methylation (GO:0061085)2.48187535
98* endoplasmic reticulum unfolded protein response (GO:0030968)2.47615355
99hypotonic response (GO:0006971)2.47072543
100embryonic camera-type eye morphogenesis (GO:0048596)2.46607594
101morphogenesis of an endothelium (GO:0003159)2.46472870
102endothelial tube morphogenesis (GO:0061154)2.46472870
103regulation of transforming growth factor beta2 production (GO:0032909)2.46277091
104negative regulation of cell fate specification (GO:0009996)2.45775224
105lung-associated mesenchyme development (GO:0060484)2.45667257
106blood vessel endothelial cell migration (GO:0043534)2.45445385
107regulation of mitotic spindle organization (GO:0060236)2.45332086
108pinocytosis (GO:0006907)2.45327287
109negative regulation of cartilage development (GO:0061037)2.44969732
110regulation of sister chromatid cohesion (GO:0007063)2.44689304
111negative regulation of histone methylation (GO:0031061)2.44659477
112DNA duplex unwinding (GO:0032508)2.44201119
113cellular response to prostaglandin stimulus (GO:0071379)2.43856270
114corticosteroid receptor signaling pathway (GO:0031958)2.43058265
115DNA geometric change (GO:0032392)2.42382544
116protein targeting to plasma membrane (GO:0072661)2.41701687
117cellular response to epidermal growth factor stimulus (GO:0071364)2.41569445
118vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41160260
119embryo implantation (GO:0007566)2.40796320
120hemidesmosome assembly (GO:0031581)2.40622368
121regulation of cell fate specification (GO:0042659)2.40170839
122cell-substrate adherens junction assembly (GO:0007045)2.40099227
123focal adhesion assembly (GO:0048041)2.40099227
124positive regulation of catenin import into nucleus (GO:0035413)2.40022152
125retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39823160
126renal system development (GO:0072001)2.39802835
127notochord development (GO:0030903)2.39701113
128mitotic nuclear envelope disassembly (GO:0007077)2.39267193
129Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38970079
130midgut development (GO:0007494)2.38779567
131positive regulation of epithelial to mesenchymal transition (GO:0010718)2.38633187
132endothelial cell chemotaxis (GO:0035767)2.37655648
133axon extension involved in axon guidance (GO:0048846)2.37601425
134neuron projection extension involved in neuron projection guidance (GO:1902284)2.37601425
135regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.37426728
136ear development (GO:0043583)2.37357598
137regulation of catenin import into nucleus (GO:0035412)2.36933486
138regulation of cholesterol biosynthetic process (GO:0045540)2.36927230
139regulation of heart morphogenesis (GO:2000826)2.36767167
140protein hydroxylation (GO:0018126)2.36259118
141regulation of extracellular matrix organization (GO:1903053)2.34323839
142regulation of translational termination (GO:0006449)2.34269375
143regulation of establishment of planar polarity (GO:0090175)2.33677722
144positive regulation of endothelial cell apoptotic process (GO:2000353)2.33590034
145positive regulation of hormone biosynthetic process (GO:0046886)2.33303796
146regulation of cholesterol homeostasis (GO:2000188)2.32794982
147NLS-bearing protein import into nucleus (GO:0006607)2.32548732
148positive regulation of histone deacetylation (GO:0031065)2.32465161
149eye morphogenesis (GO:0048592)2.32240093
150* cellular response to topologically incorrect protein (GO:0035967)2.31861318
151* cellular response to unfolded protein (GO:0034620)2.31394008
152atrioventricular valve morphogenesis (GO:0003181)2.28342395
153regulation of mammary gland epithelial cell proliferation (GO:0033599)2.28243071
154regulation of cardioblast differentiation (GO:0051890)2.27489559
155regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.26358903
156regulation of early endosome to late endosome transport (GO:2000641)2.26334231
157regulation of nucleobase-containing compound transport (GO:0032239)2.24361993
158* response to endoplasmic reticulum stress (GO:0034976)2.22956854
159receptor recycling (GO:0001881)2.21947536
160mammary gland epithelial cell proliferation (GO:0033598)2.21077619
161positive regulation of receptor recycling (GO:0001921)2.20538302
162chondrocyte development (GO:0002063)2.19569836
163amyloid precursor protein catabolic process (GO:0042987)2.18438583
164retina vasculature morphogenesis in camera-type eye (GO:0061299)2.18185335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.08727705
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.81383850
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.61605504
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.53881543
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.33404123
6CLOCK_20551151_ChIP-Seq_293T_Human2.87195410
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.71908819
8* MYC_22102868_ChIP-Seq_BL_Human2.40423331
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31502435
10* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.27139713
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.23859375
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.18386676
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.10645643
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09287583
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09287583
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09287583
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.05424762
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.03974730
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98862062
20ZNF263_19887448_ChIP-Seq_K562_Human1.96890637
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94642403
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90819820
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.84440966
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80192073
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79799439
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77964207
27AR_21909140_ChIP-Seq_LNCAP_Human1.75693634
28* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75452549
29* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72983686
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72048660
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71457832
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70672006
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70637366
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67940200
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65794194
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64698596
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64136776
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64001265
39* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63954214
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63848995
41* MYC_18555785_ChIP-Seq_MESCs_Mouse1.63408458
42KDM2B_26808549_Chip-Seq_DND41_Human1.60537670
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58809001
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58052102
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57346455
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55369115
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55351396
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52532461
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52511697
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51234963
51* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49390152
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48008044
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.47564278
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47100752
55TCF7_22412390_ChIP-Seq_EML_Mouse1.45960640
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45780585
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.45053911
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44994631
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44920031
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.43767101
61ATF3_27146783_Chip-Seq_COLON_Human1.42056428
62* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39377794
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39362973
64* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39232875
65* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38768568
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.38639458
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.38639458
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38550011
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38185798
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35826830
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35337254
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35337254
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35303368
74CHD1_26751641_Chip-Seq_LNCaP_Human1.34670996
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32575938
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32059684
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31879285
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31366990
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29651998
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28737242
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26534537
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22298425
83VDR_21846776_ChIP-Seq_THP-1_Human1.22081374
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.21792414
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21311071
86* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20193192
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.20071589
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.19139240
89* FOXO3_23340844_ChIP-Seq_DLD1_Human1.19112773
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18964444
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18846096
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18295935
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18280453
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18112752
95RXR_22158963_ChIP-Seq_LIVER_Mouse1.16602180
96NCOR1_26117541_ChIP-Seq_K562_Human1.15148402
97* KDM2B_26808549_Chip-Seq_K562_Human1.15123642
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.15038594
99CREB1_26743006_Chip-Seq_LNCaP_Human1.14838058
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14774205
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14455918
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13855803
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13233907
104* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13229539
105* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13202089
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13191920
107FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12368586
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.11903001
109LXR_22292898_ChIP-Seq_THP-1_Human1.11736721
110SMC4_20622854_ChIP-Seq_HELA_Human1.11587605
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11552505
112* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10746441
113ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09969538
114PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09560963
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.09308071
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.09177396
117TP53_22127205_ChIP-Seq_IMR90_Human1.08372194
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08087230
119NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06437928
120FOXA2_19822575_ChIP-Seq_HepG2_Human1.06322207
121SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05459520
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05456666
123BRD4_25478319_ChIP-Seq_HGPS_Human1.03151691
124POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02291400
125AHR_22903824_ChIP-Seq_MCF-7_Human1.01814209
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01508789
127* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01157337
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00943434
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00676515
130ISL1_27105846_Chip-Seq_CPCs_Mouse1.00662825
131NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00249116
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00117342
133CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98176645
134NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96746049
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.95457088
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.94288274
137WT1_19549856_ChIP-ChIP_CCG9911_Human0.93931330
138* GATA6_25053715_ChIP-Seq_YYC3_Human0.92881101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.58790947
2MP0008438_abnormal_cutaneous_collagen4.16365035
3MP0000537_abnormal_urethra_morphology2.88385901
4MP0010352_gastrointestinal_tract_polyps2.69657737
5MP0005275_abnormal_skin_tensile2.60818734
6MP0006054_spinal_hemorrhage2.57146108
7MP0010234_abnormal_vibrissa_follicle2.45925599
8MP0004272_abnormal_basement_membrane2.41368522
9MP0005623_abnormal_meninges_morphology2.38452079
10MP0010030_abnormal_orbit_morphology2.32245747
11MP0003283_abnormal_digestive_organ2.32127718
12MP0005076_abnormal_cell_differentiation2.28481522
13MP0005503_abnormal_tendon_morphology2.18287078
14MP0005058_abnormal_lysosome_morphology2.10686814
15MP0009053_abnormal_anal_canal2.10556445
16MP0005409_darkened_coat_color2.08621683
17MP0003566_abnormal_cell_adhesion2.03019292
18MP0003279_aneurysm1.92050238
19MP0003123_paternal_imprinting1.87492492
20MP0001849_ear_inflammation1.85746608
21MP0009384_cardiac_valve_regurgitation1.83666491
22MP0003191_abnormal_cellular_cholesterol1.70889044
23MP0001958_emphysema1.63164472
24MP0004197_abnormal_fetal_growth/weight/1.62615284
25MP0000733_abnormal_muscle_development1.59714785
26MP0000428_abnormal_craniofacial_morphol1.57052032
27MP0003115_abnormal_respiratory_system1.56729064
28MP0005451_abnormal_body_composition1.55963870
29MP0002796_impaired_skin_barrier1.54478614
30MP0000751_myopathy1.52572369
31MP0003119_abnormal_digestive_system1.52474772
32MP0008260_abnormal_autophagy1.52041578
33MP0005023_abnormal_wound_healing1.50231542
34MP0004858_abnormal_nervous_system1.48967771
35MP0002877_abnormal_melanocyte_morpholog1.46836230
36MP0003942_abnormal_urinary_system1.46650395
37MP0003300_gastrointestinal_ulcer1.46515198
38MP0001730_embryonic_growth_arrest1.46010556
39MP0000534_abnormal_ureter_morphology1.42506751
40* MP0002084_abnormal_developmental_patter1.39205251
41MP0003385_abnormal_body_wall1.33811069
42MP0002060_abnormal_skin_morphology1.31149921
43MP0002653_abnormal_ependyma_morphology1.30478846
44MP0001348_abnormal_lacrimal_gland1.29372086
45* MP0002085_abnormal_embryonic_tissue1.26827697
46MP0002932_abnormal_joint_morphology1.26320794
47* MP0005508_abnormal_skeleton_morphology1.25293571
48MP0004185_abnormal_adipocyte_glucose1.24165787
49MP0002086_abnormal_extraembryonic_tissu1.23645539
50MP0002282_abnormal_trachea_morphology1.21351976
51MP0004782_abnormal_surfactant_physiolog1.20420085
52MP0005380_embryogenesis_phenotype1.19645996
53MP0001672_abnormal_embryogenesis/_devel1.19645996
54MP0005257_abnormal_intraocular_pressure1.19416135
55MP0003935_abnormal_craniofacial_develop1.19189936
56MP0005501_abnormal_skin_physiology1.18713578
57* MP0002896_abnormal_bone_mineralization1.17632405
58MP0002111_abnormal_tail_morphology1.15994503
59MP0000350_abnormal_cell_proliferation1.15836131
60MP0003937_abnormal_limbs/digits/tail_de1.15237395
61MP0002009_preneoplasia1.14918912
62MP0006138_congestive_heart_failure1.14836381
63MP0002092_abnormal_eye_morphology1.14591615
64MP0002088_abnormal_embryonic_growth/wei1.14446454
65MP0003329_amyloid_beta_deposits1.13893060
66MP0003984_embryonic_growth_retardation1.13266536
67MP0001915_intracranial_hemorrhage1.12651270
68MP0000858_altered_metastatic_potential1.12447605
69MP0003091_abnormal_cell_migration1.12329650
70MP0001697_abnormal_embryo_size1.12281629
71MP0010368_abnormal_lymphatic_system1.12072318
72MP0002697_abnormal_eye_size1.12038360
73MP0009840_abnormal_foam_cell1.11534918
74* MP0004957_abnormal_blastocyst_morpholog1.11375279
75MP0010307_abnormal_tumor_latency1.10925621
76MP0003567_abnormal_fetal_cardiomyocyte1.08349490
77MP0002089_abnormal_postnatal_growth/wei1.06896586
78MP0009278_abnormal_bone_marrow1.06623468
79MP0002925_abnormal_cardiovascular_devel1.06611026
80MP0003111_abnormal_nucleus_morphology1.05960847
81MP0001661_extended_life_span1.05555438
82MP0005367_renal/urinary_system_phenotyp1.05215262
83MP0000516_abnormal_urinary_system1.05215262
84MP0002249_abnormal_larynx_morphology1.04627635
85MP0000003_abnormal_adipose_tissue1.04475118
86MP0009672_abnormal_birth_weight1.03504237
87MP0000013_abnormal_adipose_tissue1.03414079
88MP0001293_anophthalmia1.01407612
89MP0004264_abnormal_extraembryonic_tissu0.99785804
90MP0008007_abnormal_cellular_replicative0.98395225
91* MP0002080_prenatal_lethality0.97657503
92MP0000432_abnormal_head_morphology0.97080679
93MP0002234_abnormal_pharynx_morphology0.96470690
94MP0002098_abnormal_vibrissa_morphology0.96449265
95* MP0005621_abnormal_cell_physiology0.96415007
96MP0003121_genomic_imprinting0.96116972
97MP0000767_abnormal_smooth_muscle0.95664046
98MP0003077_abnormal_cell_cycle0.94432727
99MP0005666_abnormal_adipose_tissue0.92955843
100MP0003828_pulmonary_edema0.92290498
101MP0000467_abnormal_esophagus_morphology0.91837871
102MP0004233_abnormal_muscle_weight0.91678101
103MP0003172_abnormal_lysosome_physiology0.91521284
104* MP0009703_decreased_birth_body0.90761266
105MP0010678_abnormal_skin_adnexa0.90660628
106MP0003122_maternal_imprinting0.89560088
107MP0000627_abnormal_mammary_gland0.87811947
108MP0005187_abnormal_penis_morphology0.87355575
109MP0000462_abnormal_digestive_system0.85998531
110MP0001216_abnormal_epidermal_layer0.85931723
111MP0001879_abnormal_lymphatic_vessel0.85502839
112MP0003755_abnormal_palate_morphology0.84879309
113MP0002108_abnormal_muscle_morphology0.84366068
114MP0004087_abnormal_muscle_fiber0.84130806
115MP0008961_abnormal_basal_metabolism0.84027214
116MP0000759_abnormal_skeletal_muscle0.83880863
117MP0003045_fibrosis0.81753188
118MP0003453_abnormal_keratinocyte_physiol0.81458620
119MP0009780_abnormal_chondrocyte_physiolo0.80460018
120MP0002233_abnormal_nose_morphology0.79410425
121MP0003890_abnormal_embryonic-extraembry0.79290468
122MP0005375_adipose_tissue_phenotype0.78865633
123MP0002128_abnormal_blood_circulation0.78609670
124MP0001614_abnormal_blood_vessel0.77943265
125MP0003941_abnormal_skin_development0.77866943
126* MP0002116_abnormal_craniofacial_bone0.77253245
127* MP0000163_abnormal_cartilage_morphology0.77210027
128MP0001243_abnormal_dermal_layer0.77097888
129MP0010630_abnormal_cardiac_muscle0.75963614
130MP0000681_abnormal_thyroid_gland0.75876474
131MP0009931_abnormal_skin_appearance0.75081984
132MP0005248_abnormal_Harderian_gland0.74932112
133* MP0000762_abnormal_tongue_morphology0.74518064
134MP0000377_abnormal_hair_follicle0.73419329
135* MP0002113_abnormal_skeleton_development0.68731774
136MP0002166_altered_tumor_susceptibility0.68300409
137MP0000678_abnormal_parathyroid_gland0.68092724
138MP0003795_abnormal_bone_structure0.67160471
139MP0002998_abnormal_bone_remodeling0.66351015
140MP0001175_abnormal_lung_morphology0.65642272
141MP0003183_abnormal_peptide_metabolism0.65390180
142MP0004947_skin_inflammation0.63673399

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.07084535
2Ankle contracture (HP:0006466)3.93382578
3Premature rupture of membranes (HP:0001788)3.91037018
4Cerebral aneurysm (HP:0004944)3.78988418
5Shallow orbits (HP:0000586)3.78780180
6Vascular tortuosity (HP:0004948)3.34469896
7Arterial tortuosity (HP:0005116)3.32379312
8Vertebral compression fractures (HP:0002953)3.23853540
9Flat acetabular roof (HP:0003180)3.17250382
10Bladder diverticulum (HP:0000015)3.04902780
11Asymmetry of the thorax (HP:0001555)2.92788007
12Aortic aneurysm (HP:0004942)2.87318448
13Bowel diverticulosis (HP:0005222)2.80273733
14Aortic dissection (HP:0002647)2.79434362
15Broad metatarsal (HP:0001783)2.75795791
16Renal duplication (HP:0000075)2.68923171
17Short nail (HP:0001799)2.63863609
18Mitral valve prolapse (HP:0001634)2.63520635
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63282433
20Short 4th metacarpal (HP:0010044)2.63282433
21Atrophic scars (HP:0001075)2.50971822
22Broad face (HP:0000283)2.50928039
23Selective tooth agenesis (HP:0001592)2.48118761
24Hyperacusis (HP:0010780)2.47010351
25Subacute progressive viral hepatitis (HP:0006572)2.47009721
26Ulnar bowing (HP:0003031)2.42528032
27Dilatation of the ascending aorta (HP:0005111)2.42056648
28Ependymoma (HP:0002888)2.39359501
29Aneurysm (HP:0002617)2.36470843
30Abnormality of the 4th metacarpal (HP:0010012)2.35506051
31Hand muscle atrophy (HP:0009130)2.32328221
32Absent frontal sinuses (HP:0002688)2.32129317
33Cervical subluxation (HP:0003308)2.29826307
34Blue sclerae (HP:0000592)2.29298667
35Distal upper limb amyotrophy (HP:0007149)2.28750812
36Upper limb amyotrophy (HP:0009129)2.28750812
37Deep venous thrombosis (HP:0002625)2.27588522
38Soft skin (HP:0000977)2.26377143
39Biconcave vertebral bodies (HP:0004586)2.25795701
40Deviation of the hallux (HP:0010051)2.22728202
41Syringomyelia (HP:0003396)2.22705443
42Spinal cord lesions (HP:0100561)2.22705443
43Genu recurvatum (HP:0002816)2.22218785
44Missing ribs (HP:0000921)2.21928954
45Renovascular hypertension (HP:0100817)2.19645665
46Mitral regurgitation (HP:0001653)2.19415168
47J-shaped sella turcica (HP:0002680)2.17090136
48Abnormality of the distal phalanges of the toes (HP:0010182)2.14239348
49Abnormality of carpal bone ossification (HP:0006257)2.14190850
50Thin bony cortex (HP:0002753)2.14008804
51Hallux valgus (HP:0001822)2.13200023
52Lymphangioma (HP:0100764)2.11998364
53Increased connective tissue (HP:0009025)2.11236542
54Enlarged penis (HP:0000040)2.07395712
55Wormian bones (HP:0002645)2.07266596
56Abnormality of the astrocytes (HP:0100707)2.07125277
57Astrocytoma (HP:0009592)2.07125277
58Abnormality of dentin (HP:0010299)2.05599200
59Turricephaly (HP:0000262)2.04486221
60Abnormal ossification of hand bones (HP:0005921)2.04436133
61Deviation of the thumb (HP:0009603)2.03583283
62Rectal prolapse (HP:0002035)2.03363657
63Mitral stenosis (HP:0001718)2.02060553
64Right ventricular cardiomyopathy (HP:0011663)2.01712347
65Abnormality of the calcaneus (HP:0008364)1.99596671
66Distal lower limb amyotrophy (HP:0008944)1.99518004
67Fragile skin (HP:0001030)1.99007037
68Neonatal short-limb short stature (HP:0008921)1.98537169
69Pseudobulbar signs (HP:0002200)1.98330620
70Broad thumb (HP:0011304)1.97850269
71Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.97524053
72Coxa vara (HP:0002812)1.97519313
73Long toe (HP:0010511)1.97169717
74Metaphyseal cupping (HP:0003021)1.96862139
75Sparse lateral eyebrow (HP:0005338)1.93095939
76Spondylolisthesis (HP:0003302)1.91613419
77Spinal cord compression (HP:0002176)1.91396843
78Cupped ribs (HP:0000887)1.91066509
79Colon cancer (HP:0003003)1.90914490
80Urinary glycosaminoglycan excretion (HP:0003541)1.90118598
81Mucopolysacchariduria (HP:0008155)1.90118598
82Achilles tendon contracture (HP:0001771)1.89855513
83Proximal placement of thumb (HP:0009623)1.89669525
84Distal lower limb muscle weakness (HP:0009053)1.88067787
85Increased variability in muscle fiber diameter (HP:0003557)1.86760114
86Insidious onset (HP:0003587)1.86082267
87Termporal pattern (HP:0011008)1.86082267
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86070711
89Advanced eruption of teeth (HP:0006288)1.86058800
90Flat cornea (HP:0007720)1.85834229
91Insomnia (HP:0100785)1.84525825
92Gastrointestinal carcinoma (HP:0002672)1.83509571
93Malignant gastrointestinal tract tumors (HP:0006749)1.83509571
94Abnormality of the distal phalanx of the thumb (HP:0009617)1.83420842
95Spinal rigidity (HP:0003306)1.82877252
96Elbow flexion contracture (HP:0002987)1.82828623
97Peritonitis (HP:0002586)1.82787692
98Abnormality of the thoracic spine (HP:0100711)1.82709961
99Germ cell neoplasia (HP:0100728)1.82407956
100Broad long bones (HP:0005622)1.81579776
101Type 1 muscle fiber predominance (HP:0003803)1.79745876
102Elfin facies (HP:0004428)1.78820297
103Wrist flexion contracture (HP:0001239)1.78271435
104Mildly elevated creatine phosphokinase (HP:0008180)1.77939839
105Back pain (HP:0003418)1.77538832
106Dislocated radial head (HP:0003083)1.76841735
107Buphthalmos (HP:0000557)1.76006342
108Mesomelia (HP:0003027)1.75583252
109Abnormality of the Achilles tendon (HP:0005109)1.74023953
110Radial bowing (HP:0002986)1.73555417
111Osteoarthritis (HP:0002758)1.72895905
112Camptodactyly of toe (HP:0001836)1.72274951
113Abnormality of the radial head (HP:0003995)1.71620429
114Broad phalanges of the hand (HP:0009768)1.71151356
115Joint laxity (HP:0001388)1.70874335
116Increased nuchal translucency (HP:0010880)1.70618830
117Spastic diplegia (HP:0001264)1.69862347
118Hyperextensible skin (HP:0000974)1.69790364
119Overriding aorta (HP:0002623)1.69534876
120Short 5th finger (HP:0009237)1.69313510
121Abnormality of polysaccharide metabolism (HP:0011012)1.69299690
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69299690
123Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69299690
124Bowed forearm bones (HP:0003956)1.68973518
125Bowing of the arm (HP:0006488)1.68973518
126Interstitial pulmonary disease (HP:0006530)1.68456519
127Wide anterior fontanel (HP:0000260)1.68452451
128Natal tooth (HP:0000695)1.68275912
129Hemorrhage of the eye (HP:0011885)1.68227509
130Deformed sella turcica (HP:0002681)1.67675620
131Exostoses (HP:0100777)1.67479479
132Dysostosis multiplex (HP:0000943)1.67420157
133Abnormality of the acetabulum (HP:0003170)1.67060609
134Tibial bowing (HP:0002982)1.66546573
135Abnormal delivery (HP:0001787)1.64537408
136Hypoplastic ischia (HP:0003175)1.64120885
137Broad phalanx (HP:0006009)1.63783892
138Abnormality of the peritoneum (HP:0002585)1.63436017
139Overgrowth (HP:0001548)1.62896034
140Macroorchidism (HP:0000053)1.61563714
141Abnormality of oral frenula (HP:0000190)1.61154560
142Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.61022933
143Short 1st metacarpal (HP:0010034)1.61022933
144Disproportionate tall stature (HP:0001519)1.61013454
145Vertebral clefting (HP:0008428)1.61003143
146Aortic regurgitation (HP:0001659)1.60745828
147Long palpebral fissure (HP:0000637)1.60579272
148Broad finger (HP:0001500)1.60128783
149Coarse hair (HP:0002208)1.59997440
150Inguinal hernia (HP:0000023)1.59695394
151Scapular winging (HP:0003691)1.59576651
152Striae distensae (HP:0001065)1.59516930
153Osteolytic defects of the hand bones (HP:0009699)1.58749806
154Osteolytic defects of the phalanges of the hand (HP:0009771)1.58749806
155Rhizomelia (HP:0008905)1.57842143
156Ankyloglossia (HP:0010296)1.57682357
157Fibroma (HP:0010614)1.57381577
158Vertebral arch anomaly (HP:0008438)1.55560691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.30404438
2PKN23.73705929
3CDK123.20571505
4EEF2K3.17148592
5LATS12.93437648
6MAP3K102.89194178
7PRPF4B2.77405526
8PDGFRA2.76995606
9SMG12.41289906
10TTN2.35480284
11PTK62.29438777
12DDR22.27116006
13PASK2.14227828
14SIK12.09599030
15MST1R1.94688751
16ERN11.91534736
17RIPK11.83448739
18PAK41.75290370
19EPHA21.70284036
20TESK11.69317487
21LRRK21.66415396
22TYRO31.55813704
23FLT31.44317572
24SCYL21.43244295
25MTOR1.42796998
26MET1.42104054
27RPS6KB21.39049737
28LATS21.38426080
29PAK21.38104394
30IRAK31.37969150
31NEK21.37571943
32CDC71.36575277
33ICK1.35435164
34BMX1.31863016
35TGFBR11.30714991
36STK101.30091513
37PTK21.29564433
38EPHB21.26711437
39FGFR11.13995216
40FGFR21.12049409
41CDK61.11170656
42MAP3K81.09991112
43PDGFRB1.08953000
44STK31.08364719
45FGFR41.07041180
46BRD41.05424867
47NEK11.01503813
48STK381.01284586
49ALK0.97699108
50CDK40.95424042
51NEK60.94507046
52CDK70.94363056
53TTK0.93692641
54FER0.93676969
55RPS6KA40.89872031
56RPS6KA20.89373204
57PRKD20.84806258
58MAP3K60.83996125
59MYLK0.83486842
60TRPM70.82497024
61PDPK10.81811224
62MARK20.78696133
63TGFBR20.77378608
64JAK10.73143621
65CAMK1D0.72945958
66RET0.71935358
67PIK3CA0.71282158
68KSR20.70771996
69PRKD30.68874006
70EPHB10.66257030
71TSSK60.65098586
72MAP2K30.64263533
73MAP3K20.64107091
74DYRK1B0.60665573
75MAP2K20.60382317
76CHEK10.59510672
77CAMKK10.59238375
78MELK0.59094845
79ZAP700.58539988
80AKT20.57187854
81MAPK110.56619628
82RPS6KL10.55625633
83RPS6KC10.55625633
84MAP3K140.53672362
85WEE10.53030488
86AURKB0.52379975
87PAK30.51884237
88CAMK1G0.51425692
89ERBB20.51244599
90LIMK10.50858696
91MAP3K130.49523373
92HIPK20.48736240
93MAP3K30.48660726
94TAOK20.47857994
95SGK30.46235013
96CDK90.45920781
97ATR0.45510059
98KSR10.44966500
99SIK30.44268029
100MAP3K10.43466847
101CDK20.43154217
102MAPK70.43135468
103ILK0.42976554
104CDK80.42709456
105PRKCH0.41843507
106GSK3A0.40895127
107CDC42BPA0.40853303
108TBK10.40611377
109ROCK20.40590051
110FGFR30.40364208
111STK40.39747448
112GRK60.39481086
113BRSK20.38504539
114PRKCI0.38451952
115NME20.38190310
116CSNK1D0.38021393
117TYK20.37928115
118TAOK10.37752988
119PDK10.37717018
120ATM0.37648559
121PLK10.37602243
122MAP3K70.37522761
123MAPK100.37308091
124MAPK10.37282653
125DMPK0.36589650
126RPS6KB10.36130898
127PRKD10.35954735
128NEK90.35329203
129LMTK20.34560547
130PRKDC0.33050657
131INSR0.33015963
132CHUK0.32409515
133EPHA30.31864175
134TESK20.30740528
135CSNK1E0.30284587
136MAPKAPK30.29554223
137MAP2K10.29544018
138NTRK10.29542779
139CDK10.28847275

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.59208721
2Other glycan degradation_Homo sapiens_hsa005112.23402027
3Basal cell carcinoma_Homo sapiens_hsa052172.20406550
4Hippo signaling pathway_Homo sapiens_hsa043902.05268607
5Focal adhesion_Homo sapiens_hsa045102.03799176
6Small cell lung cancer_Homo sapiens_hsa052222.03104023
7Adherens junction_Homo sapiens_hsa045202.02178740
8Lysine degradation_Homo sapiens_hsa003101.98296013
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.95154007
10Proteoglycans in cancer_Homo sapiens_hsa052051.87661775
11Chronic myeloid leukemia_Homo sapiens_hsa052201.81047495
12Protein digestion and absorption_Homo sapiens_hsa049741.80263587
13Bladder cancer_Homo sapiens_hsa052191.77201888
14* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72029306
15One carbon pool by folate_Homo sapiens_hsa006701.69736986
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.68491969
17MicroRNAs in cancer_Homo sapiens_hsa052061.67791125
18TGF-beta signaling pathway_Homo sapiens_hsa043501.63203163
19Hedgehog signaling pathway_Homo sapiens_hsa043401.61826244
20Nitrogen metabolism_Homo sapiens_hsa009101.59638567
21Notch signaling pathway_Homo sapiens_hsa043301.58792843
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53281515
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49545216
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.47846223
25mTOR signaling pathway_Homo sapiens_hsa041501.46454961
26Amoebiasis_Homo sapiens_hsa051461.39977381
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37438386
28Cell cycle_Homo sapiens_hsa041101.32313560
29Selenocompound metabolism_Homo sapiens_hsa004501.30538490
30Endometrial cancer_Homo sapiens_hsa052131.30216855
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28628194
32Thyroid cancer_Homo sapiens_hsa052161.27182954
33RNA transport_Homo sapiens_hsa030131.26832964
34ErbB signaling pathway_Homo sapiens_hsa040121.25472898
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23746572
36Prostate cancer_Homo sapiens_hsa052151.19972305
37Colorectal cancer_Homo sapiens_hsa052101.19844115
38Tight junction_Homo sapiens_hsa045301.18793845
39Insulin resistance_Homo sapiens_hsa049311.17771519
40Inositol phosphate metabolism_Homo sapiens_hsa005621.12991696
41Choline metabolism in cancer_Homo sapiens_hsa052311.12070928
42HTLV-I infection_Homo sapiens_hsa051661.10848493
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10565868
44Non-small cell lung cancer_Homo sapiens_hsa052231.08845031
45mRNA surveillance pathway_Homo sapiens_hsa030151.08073394
46Pathways in cancer_Homo sapiens_hsa052001.06966502
47Viral carcinogenesis_Homo sapiens_hsa052031.06933491
48Pancreatic cancer_Homo sapiens_hsa052121.06540128
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05392871
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05076177
51Prolactin signaling pathway_Homo sapiens_hsa049171.03749509
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02030600
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01863401
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99771444
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97888799
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96233563
57Pentose phosphate pathway_Homo sapiens_hsa000300.95785780
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.95300603
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.94087100
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.93932147
61Hepatitis C_Homo sapiens_hsa051600.93329556
62Fructose and mannose metabolism_Homo sapiens_hsa000510.93231743
63N-Glycan biosynthesis_Homo sapiens_hsa005100.92362845
64Wnt signaling pathway_Homo sapiens_hsa043100.92297692
65Spliceosome_Homo sapiens_hsa030400.92018159
66p53 signaling pathway_Homo sapiens_hsa041150.91697318
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91562750
68Biosynthesis of amino acids_Homo sapiens_hsa012300.91089518
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.89661013
70Glioma_Homo sapiens_hsa052140.89420610
71Hepatitis B_Homo sapiens_hsa051610.85347940
72GnRH signaling pathway_Homo sapiens_hsa049120.83331958
73Endocytosis_Homo sapiens_hsa041440.82293582
74Estrogen signaling pathway_Homo sapiens_hsa049150.80725459
75AMPK signaling pathway_Homo sapiens_hsa041520.79129319
76Melanoma_Homo sapiens_hsa052180.78678019
77Renal cell carcinoma_Homo sapiens_hsa052110.77894899
78Lysosome_Homo sapiens_hsa041420.77889904
79Axon guidance_Homo sapiens_hsa043600.77303892
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76832305
81Viral myocarditis_Homo sapiens_hsa054160.76640541
82DNA replication_Homo sapiens_hsa030300.75632898
83Mismatch repair_Homo sapiens_hsa034300.75276887
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.74932101
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73323508
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72720717
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71862791
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71696356
89Galactose metabolism_Homo sapiens_hsa000520.71585384
90Complement and coagulation cascades_Homo sapiens_hsa046100.70785372
91Vibrio cholerae infection_Homo sapiens_hsa051100.70332029
92Toxoplasmosis_Homo sapiens_hsa051450.69978755
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.69961034
94Acute myeloid leukemia_Homo sapiens_hsa052210.67496974
95Rap1 signaling pathway_Homo sapiens_hsa040150.67085137
96B cell receptor signaling pathway_Homo sapiens_hsa046620.66571431
97Phenylalanine metabolism_Homo sapiens_hsa003600.66180609
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64630056
99Antigen processing and presentation_Homo sapiens_hsa046120.64609845
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64147729
101Melanogenesis_Homo sapiens_hsa049160.64053664
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62087294
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61587274
104Sphingolipid metabolism_Homo sapiens_hsa006000.61469394
105Prion diseases_Homo sapiens_hsa050200.59690529
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59428408
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58641468
108TNF signaling pathway_Homo sapiens_hsa046680.58164844
109Dilated cardiomyopathy_Homo sapiens_hsa054140.58020060
110Insulin signaling pathway_Homo sapiens_hsa049100.58009556
111VEGF signaling pathway_Homo sapiens_hsa043700.57283911
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57047764
113Platelet activation_Homo sapiens_hsa046110.55880559
114Thyroid hormone synthesis_Homo sapiens_hsa049180.55369703
115Fat digestion and absorption_Homo sapiens_hsa049750.54112909
116FoxO signaling pathway_Homo sapiens_hsa040680.52899081
117Dorso-ventral axis formation_Homo sapiens_hsa043200.52709054
118Shigellosis_Homo sapiens_hsa051310.52471079
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51866531
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51322873
121Gap junction_Homo sapiens_hsa045400.51317894
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50995025
123HIF-1 signaling pathway_Homo sapiens_hsa040660.50226187
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49894439
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49446021
126Renin-angiotensin system_Homo sapiens_hsa046140.48853138
127Systemic lupus erythematosus_Homo sapiens_hsa053220.48783777
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48625916
129Apoptosis_Homo sapiens_hsa042100.47617970
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.47220192
131Oocyte meiosis_Homo sapiens_hsa041140.46059180
132Fatty acid degradation_Homo sapiens_hsa000710.45932628
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45861088
134Glucagon signaling pathway_Homo sapiens_hsa049220.45453886
135Bile secretion_Homo sapiens_hsa049760.44725724
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44079107
137Nucleotide excision repair_Homo sapiens_hsa034200.42697047
138Type II diabetes mellitus_Homo sapiens_hsa049300.42540942

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