MC2R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to zinc ion (GO:0071294)9.67063490
2ketone biosynthetic process (GO:0042181)9.43621383
3progesterone metabolic process (GO:0042448)8.77905894
4hormone biosynthetic process (GO:0042446)8.64991183
5cellular response to interferon-alpha (GO:0035457)8.42955205
6response to follicle-stimulating hormone (GO:0032354)8.36799247
7cellular response to growth hormone stimulus (GO:0071378)7.81957257
8low-density lipoprotein particle clearance (GO:0034383)7.31507023
9androgen metabolic process (GO:0008209)7.30801592
10cellular response to epinephrine stimulus (GO:0071872)6.87314679
11adhesion of symbiont to host (GO:0044406)6.66101942
12Leydig cell differentiation (GO:0033327)6.56427035
13cellular response to antibiotic (GO:0071236)6.37792987
14estrogen metabolic process (GO:0008210)6.26926197
15toxin metabolic process (GO:0009404)6.17374366
16response to lead ion (GO:0010288)5.79630312
17renal system process involved in regulation of blood volume (GO:0001977)5.75338935
18response to epinephrine (GO:0071871)5.50777008
19phagocytosis, recognition (GO:0006910)5.14968547
20response to leptin (GO:0044321)5.07886677
21renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.86654064
22negative regulation of cytosolic calcium ion concentration (GO:0051481)4.72776886
23regulation of cholesterol storage (GO:0010885)4.72606536
24cellular response to gonadotropin stimulus (GO:0071371)4.69966155
25cellular response to toxic substance (GO:0097237)4.48569234
26sulfation (GO:0051923)4.42645300
27positive regulation of triglyceride biosynthetic process (GO:0010867)4.39242351
28positive regulation of hormone biosynthetic process (GO:0046886)4.37423141
29cellular ketone metabolic process (GO:0042180)4.33320490
30positive regulation of systemic arterial blood pressure (GO:0003084)4.32064336
31parturition (GO:0007567)4.21200707
32alpha-linolenic acid metabolic process (GO:0036109)4.20570232
33intracellular lipid transport (GO:0032365)4.13120884
34NADP metabolic process (GO:0006739)4.10661060
35response to interferon-alpha (GO:0035455)4.05680409
36cellular hormone metabolic process (GO:0034754)4.03116551
37cellular response to dexamethasone stimulus (GO:0071549)4.01316018
38response to growth hormone (GO:0060416)3.97101960
39cytokine metabolic process (GO:0042107)3.96102736
40steroid biosynthetic process (GO:0006694)3.95211776
41response to pheromone (GO:0019236)3.94100408
42regulation of male gonad development (GO:2000018)3.92646306
43potassium ion homeostasis (GO:0055075)3.86982350
44positive regulation of nitric-oxide synthase activity (GO:0051000)3.86929216
453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.85444878
46purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.85444878
47regulation of female gonad development (GO:2000194)3.83360374
48benzene-containing compound metabolic process (GO:0042537)3.83238426
49sterol catabolic process (GO:0016127)3.79448597
50cholesterol catabolic process (GO:0006707)3.79448597
51mating behavior (GO:0007617)3.76117614
52response to dexamethasone (GO:0071548)3.75550417
53positive regulation of male gonad development (GO:2000020)3.72915194
54response to corticosterone (GO:0051412)3.69415549
55response to methylmercury (GO:0051597)3.66363960
56vitamin D metabolic process (GO:0042359)3.57420753
57sex differentiation (GO:0007548)3.50062182
58regulation of triglyceride biosynthetic process (GO:0010866)3.48424420
59detection of molecule of bacterial origin (GO:0032490)3.48220670
60positive regulation of triglyceride metabolic process (GO:0090208)3.46976757
61acrosome reaction (GO:0007340)3.45326983
62cellular response to catecholamine stimulus (GO:0071870)3.44028145
63cellular response to monoamine stimulus (GO:0071868)3.44028145
64response to gonadotropin (GO:0034698)3.39367947
65photoreceptor cell maintenance (GO:0045494)3.35801051
66behavioral response to nicotine (GO:0035095)3.30650234
67regulation of sarcomere organization (GO:0060297)3.28646017
68sperm motility (GO:0030317)3.26664618
69triglyceride catabolic process (GO:0019433)3.24365647
70catechol-containing compound biosynthetic process (GO:0009713)3.16022413
71catecholamine biosynthetic process (GO:0042423)3.16022413
72linoleic acid metabolic process (GO:0043651)3.14083562
73bile acid biosynthetic process (GO:0006699)3.12287793
74fusion of sperm to egg plasma membrane (GO:0007342)3.10284285
75cellular ketone body metabolic process (GO:0046950)3.09825355
76cellular response to metal ion (GO:0071248)3.07569533
77positive regulation of hormone metabolic process (GO:0032352)3.07381239
78white fat cell differentiation (GO:0050872)3.06696050
79sterol metabolic process (GO:0016125)3.05768509
80negative regulation of translation, ncRNA-mediated (GO:0040033)3.02455153
81regulation of translation, ncRNA-mediated (GO:0045974)3.02455153
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.02455153
83indolalkylamine metabolic process (GO:0006586)3.00756372
84plasma lipoprotein particle clearance (GO:0034381)3.00561105
85C21-steroid hormone biosynthetic process (GO:0006700)21.0680543
86circadian sleep/wake cycle process (GO:0022410)2.99750157
87positive regulation of lipid storage (GO:0010884)2.97992910
88G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97839504
89response to cadmium ion (GO:0046686)2.97635953
90response to phenylpropanoid (GO:0080184)2.97493863
91valine metabolic process (GO:0006573)2.95329325
92response to mineralocorticoid (GO:0051385)2.92784199
93acylglycerol catabolic process (GO:0046464)2.91871427
94neutral lipid catabolic process (GO:0046461)2.91871427
95response to insecticide (GO:0017085)2.91407784
96brown fat cell differentiation (GO:0050873)2.85756788
97sodium ion homeostasis (GO:0055078)2.85263111
98indole-containing compound catabolic process (GO:0042436)2.84444697
99indolalkylamine catabolic process (GO:0046218)2.84444697
100tryptophan catabolic process (GO:0006569)2.84444697
101NAD biosynthetic process (GO:0009435)2.84082477
102response to vitamin E (GO:0033197)2.83569454
103response to monoamine (GO:0071867)2.82663775
104response to catecholamine (GO:0071869)2.82663775
105polyketide metabolic process (GO:0030638)2.82453347
106doxorubicin metabolic process (GO:0044598)2.82453347
107daunorubicin metabolic process (GO:0044597)2.82453347
108tachykinin receptor signaling pathway (GO:0007217)2.81519404
109kynurenine metabolic process (GO:0070189)2.79623088
110sex determination (GO:0007530)2.79492221
111L-fucose catabolic process (GO:0042355)2.78513416
112fucose catabolic process (GO:0019317)2.78513416
113L-fucose metabolic process (GO:0042354)2.78513416
114auditory receptor cell stereocilium organization (GO:0060088)2.77477986
115adrenal gland development (GO:0030325)2.75252322
116ketone body metabolic process (GO:1902224)2.75021022
117regulation of systemic arterial blood pressure by hormone (GO:0001990)2.74982931
118regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.74982931
119endocrine process (GO:0050886)2.74982931
120high-density lipoprotein particle remodeling (GO:0034375)2.74181922
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73149843
122reflex (GO:0060004)2.71387060
123nonmotile primary cilium assembly (GO:0035058)2.70124085
124positive regulation of vascular permeability (GO:0043117)2.70070427
125detection of light stimulus involved in sensory perception (GO:0050962)2.68693906
126detection of light stimulus involved in visual perception (GO:0050908)2.68693906
127regulation of triglyceride metabolic process (GO:0090207)2.67167062
128ovulation (GO:0030728)2.66677214
129regulation of cilium movement (GO:0003352)2.65107391
130tryptophan metabolic process (GO:0006568)2.64642285
131regulation of sequestering of triglyceride (GO:0010889)2.64181456
132cellular response to inorganic substance (GO:0071241)2.64149217
133detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63454300
134multicellular organism reproduction (GO:0032504)2.63138199
135response to antibiotic (GO:0046677)2.62490910
136regulation of steroid biosynthetic process (GO:0050810)2.61946641
137hormone metabolic process (GO:0042445)2.60618576
138cholesterol transport (GO:0030301)2.58825025
139sterol transport (GO:0015918)2.58825025
140hippocampus development (GO:0021766)2.58017492
141monoubiquitinated protein deubiquitination (GO:0035520)2.57451563
142bile acid metabolic process (GO:0008206)2.56915989
143blood vessel endothelial cell migration (GO:0043534)2.56233983
144platelet dense granule organization (GO:0060155)2.52731602
145negative regulation of heart rate (GO:0010459)2.47063820
146signal peptide processing (GO:0006465)2.45946443
147glucocorticoid biosynthetic process (GO:0006704)16.6700293
148estrogen biosynthetic process (GO:0006703)13.9794806
149glucocorticoid metabolic process (GO:0008211)13.9526785
150androgen biosynthetic process (GO:0006702)13.7964071
151C21-steroid hormone metabolic process (GO:0008207)13.1863106
152cellular response to cadmium ion (GO:0071276)12.5746092
153cellular response to follicle-stimulating hormone stimulus (GO:0071372)10.9376050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.06962642
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.84641821
3CLOCK_20551151_ChIP-Seq_293T_Human4.61050857
4EZH2_22144423_ChIP-Seq_EOC_Human4.59801422
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.51955989
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.91753129
7VDR_22108803_ChIP-Seq_LS180_Human3.65686359
8ESR1_15608294_ChIP-ChIP_MCF-7_Human3.32991705
9ZNF274_21170338_ChIP-Seq_K562_Hela3.23825046
10GBX2_23144817_ChIP-Seq_PC3_Human3.21337752
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.89546994
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.83876091
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.66850733
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63535328
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52356543
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.46724485
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.45739484
18IGF1R_20145208_ChIP-Seq_DFB_Human2.43217574
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32099676
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.29391669
21P300_19829295_ChIP-Seq_ESCs_Human2.27095813
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24954252
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14662349
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13293532
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11713504
26* LXR_22158963_ChIP-Seq_LIVER_Mouse2.10189605
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08747024
28ER_23166858_ChIP-Seq_MCF-7_Human2.05079134
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse11.2289249
30FUS_26573619_Chip-Seq_HEK293_Human1.99015405
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97548919
32TAF15_26573619_Chip-Seq_HEK293_Human1.93131013
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.91490675
34BCAT_22108803_ChIP-Seq_LS180_Human1.84083390
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83641577
36EWS_26573619_Chip-Seq_HEK293_Human1.81281736
37* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80931491
38* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.80931491
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79025239
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78971053
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77403618
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75904370
43LXR_22292898_ChIP-Seq_THP-1_Human1.75505175
44SMAD4_21799915_ChIP-Seq_A2780_Human1.75373927
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75025412
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.70772838
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70632680
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67899201
49AR_25329375_ChIP-Seq_VCAP_Human1.67849240
50STAT3_23295773_ChIP-Seq_U87_Human1.67729020
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.63467317
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62035422
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59296513
54AR_21572438_ChIP-Seq_LNCaP_Human1.58593710
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58043713
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56169492
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56135280
58TCF4_23295773_ChIP-Seq_U87_Human1.55746353
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54344496
60* TCF4_22108803_ChIP-Seq_LS180_Human1.52126155
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51133613
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50762168
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.50401663
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50321097
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.49177858
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48953775
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48662355
68CBP_20019798_ChIP-Seq_JUKART_Human1.47439994
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47439994
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.43981806
71* SMAD4_21741376_ChIP-Seq_EPCs_Human1.43939100
72NANOG_19829295_ChIP-Seq_ESCs_Human1.43793468
73SOX2_19829295_ChIP-Seq_ESCs_Human1.43793468
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43422842
75RNF2_27304074_Chip-Seq_NSC_Mouse1.41163294
76DROSHA_22980978_ChIP-Seq_HELA_Human1.40668182
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40061904
78KDM2B_26808549_Chip-Seq_DND41_Human1.39885018
79GATA1_19941826_ChIP-Seq_K562_Human1.38416425
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.37825579
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37707646
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37600322
83REST_21632747_ChIP-Seq_MESCs_Mouse1.36233943
84RUNX2_22187159_ChIP-Seq_PCA_Human1.35497262
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34792198
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34148082
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33184942
88TP53_22573176_ChIP-Seq_HFKS_Human1.31619662
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29064164
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28935659
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23692983
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22233248
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21156392
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.18196079
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18059183
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17902058
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17234446
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17100881
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.16841716
100GATA3_21878914_ChIP-Seq_MCF-7_Human1.16750819
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.16600992
102* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16458252
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15431385
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14355526
105ZNF263_19887448_ChIP-Seq_K562_Human1.14226430
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12948692
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.12503517
108* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12029760
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11884778
110RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11457977
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11457977
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.11162053
113VDR_21846776_ChIP-Seq_THP-1_Human1.11104883
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10633877
115KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10223981
116* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09617878
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09087136
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08786439
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08225802
120EZH2_27304074_Chip-Seq_ESCs_Mouse1.07213053
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06188455
122RACK7_27058665_Chip-Seq_MCF-7_Human1.06174828
123CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04671900
124* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04506240
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04270797
126ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04114923
127NOTCH1_21737748_ChIP-Seq_TLL_Human1.04099628
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.03550760
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.02667959
130FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02667959
131JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02144825
132* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.01934394
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01093959
134* SMAD4_21741376_ChIP-Seq_HESCs_Human1.01018747
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00978746
136EGR1_19032775_ChIP-ChIP_M12_Human1.00872398
137TBL1_22424771_ChIP-Seq_293T_Human1.00652929
138P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00399777
139* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00236452
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99967617
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98887287
142SOX2_21211035_ChIP-Seq_LN229_Gbm0.98659030
143NCOR_22424771_ChIP-Seq_293T_Human0.98107276
144P53_22387025_ChIP-Seq_ESCs_Mouse0.98101674
145CDX2_22108803_ChIP-Seq_LS180_Human0.97957778
146GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97655606
147KDM2B_26808549_Chip-Seq_REH_Human0.97588888
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.97173716
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97135956
150NFYA_21822215_ChIP-Seq_K562_Human0.96887548
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.96785657
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96334830
153KDM2B_26808549_Chip-Seq_K562_Human0.94222022
154MYC_22102868_ChIP-Seq_BL_Human0.92929564
155DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91664770
156EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90466960
157TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90251515
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89739413
159NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89632922
160EGR1_19374776_ChIP-ChIP_THP-1_Human0.85504571
161ATF3_27146783_Chip-Seq_COLON_Human0.85209432
162TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84907631
163SPI1_20517297_ChIP-Seq_HL60_Human0.83864164
164* CDX2_20551321_ChIP-Seq_CACO-2_Human0.83808597
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82845322
166* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82402666
167FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81549897
168DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81113583
169MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80050656
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.79430103
171GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78351511
172STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77800941
173P68_20966046_ChIP-Seq_HELA_Human0.77461037
174SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.77392397
175KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74897695
176* TBX20_22080862_ChIP-Seq_HEART_Mouse0.74489049
177* TBX20_22328084_ChIP-Seq_HEART_Mouse0.74489049
178MYB_21317192_ChIP-Seq_ERMYB_Mouse0.73962269
179EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.73853816
180PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73431247
181JARID2_20075857_ChIP-Seq_MESCs_Mouse0.72972517
182GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72717316
183ELK4_26923725_Chip-Seq_MESODERM_Mouse0.71805651
184TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.71534631
185SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.71362686
186UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.71198261
187GATA1_19941827_ChIP-Seq_MEL_Mouse0.71089474
188P63_26484246_Chip-Seq_KERATINOCYTES_Human0.70679316
189EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.70093904
190SCL_19346495_ChIP-Seq_HPC-7_Human0.69538801
191KDM2B_26808549_Chip-Seq_JURKAT_Human0.69435530
192TET1_21451524_ChIP-Seq_MESCs_Mouse0.69377620
193EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.68828410
194CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.68401809
195TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.68113441
196SA1_27219007_Chip-Seq_ERYTHROID_Human0.67113282
197SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.65699152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002909_abnormal_adrenal_gland7.83607640
2* MP0000639_abnormal_adrenal_gland6.45799750
3MP0008995_early_reproductive_senescence4.23172490
4MP0003186_abnormal_redox_activity3.51485146
5MP0003011_delayed_dark_adaptation3.43755074
6MP0000230_abnormal_systemic_arterial3.39102077
7MP0005670_abnormal_white_adipose3.38312694
8MP0005083_abnormal_biliary_tract3.27769555
9MP0004130_abnormal_muscle_cell3.15538121
10MP0002822_catalepsy3.03408933
11MP0003941_abnormal_skin_development2.95379558
12MP0005319_abnormal_enzyme/_coenzyme2.88518115
13MP0004084_abnormal_cardiac_muscle2.84143927
14* MP0001765_abnormal_ion_homeostasis2.80020976
15MP0010329_abnormal_lipoprotein_level2.70567139
16MP0005666_abnormal_adipose_tissue2.52871254
17MP0005410_abnormal_fertilization2.45608223
18MP0003638_abnormal_response/metabolism_2.44332821
19MP0004185_abnormal_adipocyte_glucose2.41521842
20MP0003724_increased_susceptibility_to2.27434762
21MP0005253_abnormal_eye_physiology2.25061388
22MP0008875_abnormal_xenobiotic_pharmacok2.22164829
23MP0003195_calcinosis2.18559273
24MP0006276_abnormal_autonomic_nervous2.16680566
25MP0006072_abnormal_retinal_apoptosis2.13929216
26MP0004883_abnormal_blood_vessel2.10269688
27MP0005375_adipose_tissue_phenotype2.08969996
28MP0005584_abnormal_enzyme/coenzyme_acti2.08284642
29* MP0005636_abnormal_mineral_homeostasis2.06474437
30MP0005551_abnormal_eye_electrophysiolog2.04621457
31MP0002938_white_spotting2.04230920
32MP0008438_abnormal_cutaneous_collagen1.99925959
33MP0008877_abnormal_DNA_methylation1.98608022
34MP0001756_abnormal_urination1.96742006
35MP0003878_abnormal_ear_physiology1.82095827
36MP0005377_hearing/vestibular/ear_phenot1.82095827
37MP0000647_abnormal_sebaceous_gland1.81972128
38MP0005187_abnormal_penis_morphology1.81041313
39MP0001486_abnormal_startle_reflex1.80113847
40MP0005647_abnormal_sex_gland1.75535176
41MP0006138_congestive_heart_failure1.73442965
42MP0000003_abnormal_adipose_tissue1.72548286
43MP0003300_gastrointestinal_ulcer1.70403294
44MP0003136_yellow_coat_color1.70077268
45MP0002736_abnormal_nociception_after1.68865693
46MP0001968_abnormal_touch/_nociception1.67437449
47MP0003191_abnormal_cellular_cholesterol1.66997026
48MP0005167_abnormal_blood-brain_barrier1.66685428
49MP0000372_irregular_coat_pigmentation1.61826181
50MP0001485_abnormal_pinna_reflex1.61757395
51MP0002118_abnormal_lipid_homeostasis1.61372143
52MP0003718_maternal_effect1.59978328
53MP0004036_abnormal_muscle_relaxation1.58444935
54MP0009643_abnormal_urine_homeostasis1.57057710
55MP0003646_muscle_fatigue1.56198296
56MP0001984_abnormal_olfaction1.52747611
57* MP0003953_abnormal_hormone_level1.51645827
58MP0000343_altered_response_to1.50842014
59MP0000631_abnormal_neuroendocrine_gland1.50049836
60MP0002557_abnormal_social/conspecific_i1.49083958
61MP0000013_abnormal_adipose_tissue1.48461266
62MP0008775_abnormal_heart_ventricle1.47267391
63MP0003121_genomic_imprinting1.46667579
64MP0004142_abnormal_muscle_tone1.45732368
65MP0001929_abnormal_gametogenesis1.44210903
66MP0009745_abnormal_behavioral_response1.44142499
67MP0005379_endocrine/exocrine_gland_phen1.41610715
68MP0005164_abnormal_response_to1.40891400
69MP0010630_abnormal_cardiac_muscle1.39638871
70MP0005535_abnormal_body_temperature1.38148942
71MP0002971_abnormal_brown_adipose1.31857464
72MP0003698_abnormal_male_reproductive1.30129800
73MP0001501_abnormal_sleep_pattern1.28159342
74MP0002970_abnormal_white_adipose1.28149206
75MP0009780_abnormal_chondrocyte_physiolo1.27757203
76MP0009046_muscle_twitch1.27083141
77MP0000609_abnormal_liver_physiology1.24220597
78MP0002638_abnormal_pupillary_reflex1.22843650
79MP0002735_abnormal_chemical_nociception1.22747875
80MP0005334_abnormal_fat_pad1.22427598
81MP0005645_abnormal_hypothalamus_physiol1.19106319
82MP0003786_premature_aging1.18705399
83MP0002572_abnormal_emotion/affect_behav1.17812787
84MP0001905_abnormal_dopamine_level1.16751034
85MP0008057_abnormal_DNA_replication1.16581637
86MP0002733_abnormal_thermal_nociception1.16555656
87MP0001879_abnormal_lymphatic_vessel1.16408068
88MP0004742_abnormal_vestibular_system1.15454236
89MP0006292_abnormal_olfactory_placode1.14696738
90MP0009115_abnormal_fat_cell1.14536010
91MP0001544_abnormal_cardiovascular_syste1.14211785
92MP0005385_cardiovascular_system_phenoty1.14211785
93MP0004087_abnormal_muscle_fiber1.13047745
94MP0003656_abnormal_erythrocyte_physiolo1.12404528
95MP0001970_abnormal_pain_threshold1.09717564
96MP0003828_pulmonary_edema1.09423130
97MP0003123_paternal_imprinting1.05941065
98MP0000653_abnormal_sex_gland1.05735486
99MP0008469_abnormal_protein_level1.05358080
100MP0002210_abnormal_sex_determination1.04987445
101MP0005275_abnormal_skin_tensile1.03988858
102MP0004272_abnormal_basement_membrane1.02712056
103MP0009840_abnormal_foam_cell1.02311625
104MP0001529_abnormal_vocalization1.01975457
105MP0004043_abnormal_pH_regulation1.01691062
106MP0005085_abnormal_gallbladder_physiolo1.00047304
107* MP0002078_abnormal_glucose_homeostasis0.99391267
108MP0008961_abnormal_basal_metabolism0.98282029
109MP0003122_maternal_imprinting0.96755829
110MP0000538_abnormal_urinary_bladder0.96596884
111MP0002272_abnormal_nervous_system0.96582172
112MP0003950_abnormal_plasma_membrane0.96333255
113MP0003705_abnormal_hypodermis_morpholog0.96295559
114MP0008872_abnormal_physiological_respon0.95963613
115MP0001440_abnormal_grooming_behavior0.95788509
116MP0003787_abnormal_imprinting0.94642168
117MP0003948_abnormal_gas_homeostasis0.94480230
118MP0005391_vision/eye_phenotype0.93949711
119MP0005646_abnormal_pituitary_gland0.93676558
120* MP0005452_abnormal_adipose_tissue0.93528283
121MP0003315_abnormal_perineum_morphology0.93440674
122MP0005503_abnormal_tendon_morphology0.93251526
123MP0001963_abnormal_hearing_physiology0.93175590
124MP0005595_abnormal_vascular_smooth0.93175003
125MP0003880_abnormal_central_pattern0.91856052
126MP0003942_abnormal_urinary_system0.91317451
127MP0002295_abnormal_pulmonary_circulatio0.89036156
128MP0001145_abnormal_male_reproductive0.88573632
129MP0000026_abnormal_inner_ear0.88515032
130MP0003566_abnormal_cell_adhesion0.88365888
131MP0005448_abnormal_energy_balance0.88206678
132MP0000266_abnormal_heart_morphology0.88103953
133MP0001177_atelectasis0.87883421
134MP0002067_abnormal_sensory_capabilities0.87357244
135MP0002160_abnormal_reproductive_system0.86112510
136MP0010386_abnormal_urinary_bladder0.86070091
137MP0005365_abnormal_bile_salt0.83705473
138MP0001293_anophthalmia0.82752432
139MP0000751_myopathy0.80295435
140MP0001661_extended_life_span0.79250510
141MP0009697_abnormal_copulation0.78961185
142MP0000249_abnormal_blood_vessel0.78006998
143MP0002184_abnormal_innervation0.77449309
144MP0004215_abnormal_myocardial_fiber0.77142589
145MP0010368_abnormal_lymphatic_system0.76289705
146MP0005084_abnormal_gallbladder_morpholo0.76119804
147MP0002064_seizures0.75946119
148MP0002102_abnormal_ear_morphology0.75717049
149MP0002234_abnormal_pharynx_morphology0.75020050
150MP0000566_synostosis0.73662031
151MP0000778_abnormal_nervous_system0.73523175
152* MP0004085_abnormal_heartbeat0.73201040
153MP0002837_dystrophic_cardiac_calcinosis0.73111502
154* MP0009642_abnormal_blood_homeostasis0.72985899
155MP0003635_abnormal_synaptic_transmissio0.71870438
156MP0009053_abnormal_anal_canal0.70947411
157MP0002069_abnormal_eating/drinking_beha0.70759670
158MP0000598_abnormal_liver_morphology0.69819176
159MP0002229_neurodegeneration0.69814773
160MP0005395_other_phenotype0.69718894
161MP0009250_abnormal_appendicular_skeleto0.67345226
162MP0002269_muscular_atrophy0.66879793
163MP0004147_increased_porphyrin_level0.65593565
164MP0001614_abnormal_blood_vessel0.60691102
165MP0002136_abnormal_kidney_physiology0.60415797
166MP0006036_abnormal_mitochondrial_physio0.60137896
167MP0003959_abnormal_lean_body0.59841994
168MP0003221_abnormal_cardiomyocyte_apopto0.58777552
169MP0002135_abnormal_kidney_morphology0.57509966
170MP0006035_abnormal_mitochondrial_morpho0.56798807
171MP0005397_hematopoietic_system_phenotyp0.56723463
172MP0001545_abnormal_hematopoietic_system0.56723463
173MP0001119_abnormal_female_reproductive0.55766288
174MP0003091_abnormal_cell_migration0.55371399
175MP0005389_reproductive_system_phenotype0.55262966
176MP0005388_respiratory_system_phenotype0.53696506
177MP0002133_abnormal_respiratory_system0.53696506
178MP0004145_abnormal_muscle_electrophysio0.49297398

Predicted human phenotypes

RankGene SetZ-score
1Enlarged penis (HP:0000040)9.91540961
2Increased circulating renin level (HP:0000848)9.30339397
3Abnormality of renin-angiotensin system (HP:0000847)9.16509137
4Orthostatic hypotension (HP:0001278)8.00955162
5Hyperaldosteronism (HP:0000859)7.76648239
6Neonatal onset (HP:0003623)7.26759056
7Hypoplasia of the uterus (HP:0000013)7.12805841
8Hyperkalemia (HP:0002153)5.79705487
9Aplasia/hypoplasia of the uterus (HP:0008684)5.70682150
10Abnormal sex determination (HP:0012244)5.00178216
11Sex reversal (HP:0012245)5.00178216
12Episodic fever (HP:0001954)4.52478933
13Abnormality of potassium homeostasis (HP:0011042)4.48656623
14Adrenal overactivity (HP:0002717)4.46027778
15Azoospermia (HP:0000027)4.21575214
16Clitoromegaly (HP:0000057)3.85289543
17Bifid scrotum (HP:0000048)3.78954338
18Testicular neoplasm (HP:0010788)3.71211735
19Genetic anticipation (HP:0003743)3.63633109
20Hyponatremia (HP:0002902)3.63250739
21Abnormal autonomic nervous system physiology (HP:0012332)3.61995911
22Bilateral microphthalmos (HP:0007633)3.56210877
23Attenuation of retinal blood vessels (HP:0007843)3.52612168
24Hypokalemic alkalosis (HP:0001949)3.49050960
25Congenital stationary night blindness (HP:0007642)3.44875104
26Decreased central vision (HP:0007663)3.41256575
27Abnormality of the pubic bones (HP:0003172)3.39669836
28Pancreatic cysts (HP:0001737)3.28641485
29Morphological abnormality of the middle ear (HP:0008609)3.21557067
30Abnormality of sodium homeostasis (HP:0010931)3.18628808
31Neonatal hypoglycemia (HP:0001998)3.18012170
32Hypokalemia (HP:0002900)3.11910080
33Absent eyebrow (HP:0002223)3.08630935
34Bicornuate uterus (HP:0000813)3.06246452
35Bifid tongue (HP:0010297)3.05088035
36Abnormal spermatogenesis (HP:0008669)3.02926826
37Pancreatic fibrosis (HP:0100732)3.02057818
38True hermaphroditism (HP:0010459)2.95587439
39Hypotension (HP:0002615)2.94480515
40Nephronophthisis (HP:0000090)2.93560830
41Genital tract atresia (HP:0001827)2.88828446
42Primary adrenal insufficiency (HP:0008207)2.87548086
43Vaginal atresia (HP:0000148)2.84776963
44Bony spicule pigmentary retinopathy (HP:0007737)2.82981772
45Progressive cerebellar ataxia (HP:0002073)2.81720702
46Premature ovarian failure (HP:0008209)2.79813511
47Abnormal rod and cone electroretinograms (HP:0008323)2.79212594
48Gaze-evoked nystagmus (HP:0000640)2.68109359
49Multifactorial inheritance (HP:0001426)2.65351509
50Gonadal dysgenesis (HP:0000133)2.65288878
51Sclerocornea (HP:0000647)2.65158080
52Retinal dysplasia (HP:0007973)2.64175767
53Abolished electroretinogram (ERG) (HP:0000550)2.57302319
54* Accelerated skeletal maturation (HP:0005616)2.55650801
55Abnormality of the renal medulla (HP:0100957)2.53547697
56Abnormality of the clitoris (HP:0000056)2.53417505
57Oligomenorrhea (HP:0000876)2.50384160
58Abnormality of the renal cortex (HP:0011035)2.49584974
59Abnormality of midbrain morphology (HP:0002418)2.43516348
60Molar tooth sign on MRI (HP:0002419)2.43516348
61Hyperglycinuria (HP:0003108)2.42482372
62Abnormal hemoglobin (HP:0011902)2.40802012
63Abnormal drinking behavior (HP:0030082)2.40302795
64Polydipsia (HP:0001959)2.40302795
65Precocious puberty (HP:0000826)2.37907496
66Medial flaring of the eyebrow (HP:0010747)2.35522901
67Female pseudohermaphroditism (HP:0010458)2.34810487
68Cupped ear (HP:0000378)2.33645883
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.32947996
70Septate vagina (HP:0001153)2.30373338
71Secondary amenorrhea (HP:0000869)2.29905897
72Anophthalmia (HP:0000528)2.29264820
73Hyperventilation (HP:0002883)2.25741952
74Male pseudohermaphroditism (HP:0000037)2.24396072
75Hypothermia (HP:0002045)2.22812060
76Cutaneous finger syndactyly (HP:0010554)2.22334563
77Hypoplastic ischia (HP:0003175)2.19892250
78Acanthosis nigricans (HP:0000956)2.18544874
79Congenital sensorineural hearing impairment (HP:0008527)2.18085724
80Hydroxyprolinuria (HP:0003080)2.16968760
81Abnormality of proline metabolism (HP:0010907)2.16968760
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16847325
83Abnormality of macular pigmentation (HP:0008002)2.16182802
84Hyperpituitarism (HP:0010514)2.15226885
85Cystic liver disease (HP:0006706)2.13470599
86Abnormality of glycine metabolism (HP:0010895)2.12862020
87Abnormality of serine family amino acid metabolism (HP:0010894)2.12862020
88Complement deficiency (HP:0004431)2.11907039
89Chronic hepatic failure (HP:0100626)2.11592533
90Type II lissencephaly (HP:0007260)2.10202382
91Absent/shortened dynein arms (HP:0200106)2.09696419
92Dynein arm defect of respiratory motile cilia (HP:0012255)2.09696419
93Abnormality of the ischium (HP:0003174)2.06332102
94Abnormality of secondary sexual hair (HP:0009888)2.04889103
95Abnormality of the axillary hair (HP:0100134)2.04889103
96Midline defect of the nose (HP:0004122)2.04422442
97Renal salt wasting (HP:0000127)12.5916419
98Decreased circulating renin level (HP:0003351)10.2694404
99Myelomeningocele (HP:0002475)1.96055559
100Increased muscle lipid content (HP:0009058)1.94519766
101Severe visual impairment (HP:0001141)1.94503934
102Breech presentation (HP:0001623)1.93918144
103Polyuria (HP:0000103)1.93849406
104Hypertriglyceridemia (HP:0002155)1.92541215
105Absent eyelashes (HP:0000561)1.90011398
106Epidermoid cyst (HP:0200040)1.89994281
107Ankle contracture (HP:0006466)1.88953880
108Broad metatarsal (HP:0001783)1.88218009
109Increased corneal curvature (HP:0100692)1.87534988
110Keratoconus (HP:0000563)1.87534988
111Hypospadias (HP:0000047)1.86947203
112Abnormal lung lobation (HP:0002101)1.86861698
113Renal cortical cysts (HP:0000803)1.86641008
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.86429905
115Scrotal hypoplasia (HP:0000046)1.85130951
116Autoimmune thrombocytopenia (HP:0001973)1.84193083
117Macular degeneration (HP:0000608)1.82978335
118Abnormality of the labia minora (HP:0012880)1.82198930
119Shawl scrotum (HP:0000049)1.82074090
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.81886525
121Alkalosis (HP:0001948)1.81580415
122Abnormal ciliary motility (HP:0012262)1.81126506
123Broad alveolar ridges (HP:0000187)1.80162979
124Potter facies (HP:0002009)1.80009147
125Facial shape deformation (HP:0011334)1.80009147
126Renal hypoplasia (HP:0000089)1.79816703
127Congenital hepatic fibrosis (HP:0002612)1.77809261
128Primary amenorrhea (HP:0000786)1.77508320
129Tubular atrophy (HP:0000092)1.76678315
130Absent hair (HP:0002298)1.73856434
131Sparse lateral eyebrow (HP:0005338)1.73437786
132Abnormality of alanine metabolism (HP:0010916)1.73291078
133Hyperalaninemia (HP:0003348)1.73291078
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73291078
135Febrile seizures (HP:0002373)1.73198556
136Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72276118
137Breast hypoplasia (HP:0003187)1.70422364
138Congenital primary aphakia (HP:0007707)1.70347233
139Inability to walk (HP:0002540)1.70244908
140Cutaneous syndactyly (HP:0012725)1.69310324
141Choanal stenosis (HP:0000452)1.67317328
142Vomiting (HP:0002013)1.66915745
143Abnormality of complement system (HP:0005339)1.66825075
144Lymphangioma (HP:0100764)1.64888970
145Abnormality of the heme biosynthetic pathway (HP:0010472)1.62105895
146Pigmentary retinal degeneration (HP:0001146)1.59071637
147Atrioventricular block (HP:0001678)1.55155264
148Ketoacidosis (HP:0001993)1.54510313
149Myoglobinuria (HP:0002913)1.53234493
150Growth hormone excess (HP:0000845)1.50793428
151Ketosis (HP:0001946)1.50733252
152Axonal loss (HP:0003447)1.45991686
153Abnormality of fatty-acid metabolism (HP:0004359)1.45954450
154Hypoglycemic coma (HP:0001325)1.45355367
155Facial hemangioma (HP:0000329)1.44371555
156Spinal rigidity (HP:0003306)1.41007690
157Protrusio acetabuli (HP:0003179)1.36755514
158Pulmonary fibrosis (HP:0002206)1.36171899
159Coronal craniosynostosis (HP:0004440)1.35354515
160Hyperlipoproteinemia (HP:0010980)1.35007198
161Hyperammonemia (HP:0001987)1.33479649
162Dehydration (HP:0001944)1.32624428
163Gastrointestinal dysmotility (HP:0002579)1.32565045
164Rectal prolapse (HP:0002035)1.32013257
165Aplasia of the musculature (HP:0100854)1.31003588
166Difficulty running (HP:0009046)1.28793039
167Increased connective tissue (HP:0009025)1.28458154
168Dicarboxylic aciduria (HP:0003215)1.27713494
169Abnormality of dicarboxylic acid metabolism (HP:0010995)1.27713494
170Prolonged QT interval (HP:0001657)1.26807657
171Multiple enchondromatosis (HP:0005701)1.24785966
172Hemorrhage of the eye (HP:0011885)1.24286621
173Turricephaly (HP:0000262)1.22798058
174Nephritis (HP:0000123)1.22682331
175Skin nodule (HP:0200036)1.21992938
176Nausea (HP:0002018)1.19907851
177Bone cyst (HP:0012062)1.17227575
178Polycythemia (HP:0001901)1.17187520
179Hypercortisolism (HP:0001578)1.15407318
180Xanthomatosis (HP:0000991)1.15369649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT38.84717247
2FRK6.81110248
3TRIB36.10417591
4ERN14.94331739
5SIK13.63707878
6MAP4K23.54737338
7BCKDK2.69035193
8ADRBK22.54200033
9CAMK1D2.47437348
10BMPR1B2.42121976
11CDK72.41943463
12GRK12.38305574
13CAMK1G2.31184890
14WNK32.30418356
15TAOK32.26185068
16EPHB22.20661799
17ACVR1B2.16482424
18RIPK12.13854336
19PKN22.07049172
20TIE12.06739754
21ZAK1.84060263
22NUAK11.80835160
23PLK41.75350619
24TGFBR21.68026860
25MAPK131.60549449
26KDR1.57372912
27FGFR41.54620303
28MAPKAPK51.46431918
29EPHA41.44747809
30CASK1.43880397
31NTRK31.41970448
32MAP3K41.40685811
33FGFR21.34909661
34TBK11.30089175
35MST1R1.26861994
36PRKCE1.25161234
37PNCK1.21747210
38GRK51.19751138
39CSNK1G21.17763590
40TXK1.15368310
41PLK21.14682672
42MUSK1.14183687
43MAP2K21.13867170
44DDR21.13001480
45ADRBK11.12601968
46MAP2K11.11446558
47TNIK1.10379150
48LRRK21.10027025
49CSNK1G11.02290953
50MKNK20.96926968
51CSNK1G30.96742291
52TLK10.93701215
53OXSR10.93335328
54SIK30.91325329
55PTK60.90721954
56MAP3K70.89005099
57PDK40.88782099
58PDK30.88782099
59PRKCG0.87917968
60KSR20.87525859
61MAPK30.87232434
62MST40.86894812
63PRKD10.83267516
64ICK0.81081122
65SIK20.80478052
66ILK0.79456428
67PDGFRA0.76654459
68TRIM280.76180049
69CDK90.76069436
70MAP2K70.73509546
71TGFBR10.71371917
72PDPK10.71358426
73MARK20.71063293
74MET0.70363657
75NME10.67862596
76INSRR0.67345793
77STK38L0.65304230
78CAMK10.65070520
79PINK10.64231678
80FER0.62510366
81PAK40.61106331
82PIK3CG0.60341261
83FGFR10.56987998
84RIPK40.56406058
85MAPK120.55592338
86ITK0.54454134
87NLK0.53687123
88PRKACG0.53193605
89DAPK20.51934740
90CSNK1A10.51684264
91PKN10.51497845
92TYK20.49966999
93LATS10.49013434
94PRKAA20.48775180
95VRK10.48584054
96MKNK10.48120101
97PTK2B0.48104426
98ERBB30.47949062
99CAMK2A0.47853006
100MTOR0.45904660
101CDK30.45172285
102FLT30.45008213
103STK30.44732076
104PRKG10.44048319
105PRKCA0.43780832
106IGF1R0.43602732
107DYRK20.42334486
108NTRK10.41658339
109EIF2AK30.41508378
110PRKD30.41451614
111SYK0.41164051
112PASK0.40894140
113MAP3K10.40691959
114GSK3A0.40426781
115PIK3CA0.39437470
116KIT0.39205439
117PAK20.39101467
118JAK20.39090486
119JAK30.38909575
120ROCK10.38331153
121TNK20.37011297
122PRKG20.36510627
123CAMKK20.36428634
124IKBKB0.36424783
125PRKCH0.36391221
126PTK20.36192463
127EGFR0.35801121
128ERBB20.35206297
129PRKAA10.34926466
130ARAF0.34256515
131PLK10.33654264
132TSSK60.33387251
133BTK0.32641785
134BCR0.32597436
135NTRK20.32260628
136SGK10.32125322
137MAPK10.31775266
138PRKCB0.30891884
139NEK20.30748771
140PRKACA0.30432281
141SRC0.30009092
142PAK30.29690124
143RET0.29397315
144LMTK20.29188402
145LATS20.27951568
146CHUK0.27697360
147MAPKAPK30.27501167
148HIPK20.26896969
149ALK0.26624753
150BMX0.25343021
151STK390.25219193
152MAP3K130.25127412
153MAPK110.25109820
154CSNK1A1L0.24456302
155CDK60.24418837
156RPS6KA30.23126318
157TEC0.22600792
158WNK40.21955019
159PDK20.21739881
160PRKACB0.20452143
161MAPK150.19903756
162PDK10.19143183
163RAF10.17847013
164CAMKK10.17539699
165CDK50.17407676
166ABL20.16256244
167TTN0.16002618
168DMPK0.15831545
169MAP3K20.15769856

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001407.72730295
2* Aldosterone synthesis and secretion_Homo sapiens_hsa049255.49332726
3Ovarian steroidogenesis_Homo sapiens_hsa049134.68401058
4Fatty acid metabolism_Homo sapiens_hsa012123.47672366
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.25563775
6Tyrosine metabolism_Homo sapiens_hsa003503.13886954
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.92263275
8Fatty acid biosynthesis_Homo sapiens_hsa000612.91394788
9PPAR signaling pathway_Homo sapiens_hsa033202.89092678
10Fatty acid degradation_Homo sapiens_hsa000712.71885418
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.58963707
12Propanoate metabolism_Homo sapiens_hsa006402.58277602
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44728568
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.41955107
15Selenocompound metabolism_Homo sapiens_hsa004502.30203204
16Phototransduction_Homo sapiens_hsa047442.28151366
17Nicotine addiction_Homo sapiens_hsa050332.27592092
18Fat digestion and absorption_Homo sapiens_hsa049752.19854292
19Taste transduction_Homo sapiens_hsa047421.89088562
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87583204
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82142579
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77140883
23Vitamin digestion and absorption_Homo sapiens_hsa049771.71857463
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66898201
25Pyruvate metabolism_Homo sapiens_hsa006201.64180579
26* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61365326
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60551631
28Olfactory transduction_Homo sapiens_hsa047401.59946044
29Retinol metabolism_Homo sapiens_hsa008301.51991221
30Carbon metabolism_Homo sapiens_hsa012001.38726939
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32419878
32Ether lipid metabolism_Homo sapiens_hsa005651.32116637
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32051900
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27157869
35GABAergic synapse_Homo sapiens_hsa047271.26536242
36beta-Alanine metabolism_Homo sapiens_hsa004101.22870069
37Sulfur metabolism_Homo sapiens_hsa009201.22732108
38Glycerolipid metabolism_Homo sapiens_hsa005611.20137149
39Nitrogen metabolism_Homo sapiens_hsa009101.18202363
40Bile secretion_Homo sapiens_hsa049761.17202760
41ABC transporters_Homo sapiens_hsa020101.15809889
42Serotonergic synapse_Homo sapiens_hsa047261.12979451
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07781709
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.02901312
45Glutamatergic synapse_Homo sapiens_hsa047241.02275325
46Renin secretion_Homo sapiens_hsa049241.00670665
47Homologous recombination_Homo sapiens_hsa034401.00117931
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00041524
49Arachidonic acid metabolism_Homo sapiens_hsa005900.94782597
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.94777597
51Fatty acid elongation_Homo sapiens_hsa000620.92304013
52Caffeine metabolism_Homo sapiens_hsa002320.91611693
53Salivary secretion_Homo sapiens_hsa049700.85321251
54Asthma_Homo sapiens_hsa053100.85318636
55Steroid biosynthesis_Homo sapiens_hsa001000.84179473
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.83636970
57Peroxisome_Homo sapiens_hsa041460.83410322
58Fanconi anemia pathway_Homo sapiens_hsa034600.82004420
59Basal transcription factors_Homo sapiens_hsa030220.81831737
60Insulin secretion_Homo sapiens_hsa049110.74331816
61AMPK signaling pathway_Homo sapiens_hsa041520.73817276
62Insulin resistance_Homo sapiens_hsa049310.73130290
63Butanoate metabolism_Homo sapiens_hsa006500.72672327
64Oxidative phosphorylation_Homo sapiens_hsa001900.68568208
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66105107
66Type I diabetes mellitus_Homo sapiens_hsa049400.65945563
67Calcium signaling pathway_Homo sapiens_hsa040200.63912073
68Tryptophan metabolism_Homo sapiens_hsa003800.60901134
69RNA polymerase_Homo sapiens_hsa030200.60623299
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60500773
71Protein export_Homo sapiens_hsa030600.59195998
72Lysine degradation_Homo sapiens_hsa003100.58837736
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58482506
74Prostate cancer_Homo sapiens_hsa052150.58342861
75Staphylococcus aureus infection_Homo sapiens_hsa051500.56958706
76RNA degradation_Homo sapiens_hsa030180.55407763
77Sphingolipid metabolism_Homo sapiens_hsa006000.54814754
78Arginine and proline metabolism_Homo sapiens_hsa003300.51020866
79Graft-versus-host disease_Homo sapiens_hsa053320.50445874
80Gastric acid secretion_Homo sapiens_hsa049710.47643393
81Purine metabolism_Homo sapiens_hsa002300.45682637
82Pentose phosphate pathway_Homo sapiens_hsa000300.43471653
83Allograft rejection_Homo sapiens_hsa053300.41882611
84Long-term depression_Homo sapiens_hsa047300.41726538
85Regulation of autophagy_Homo sapiens_hsa041400.41218350
86Cholinergic synapse_Homo sapiens_hsa047250.40589041
87Phenylalanine metabolism_Homo sapiens_hsa003600.40251682
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39319336
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38996206
90Insulin signaling pathway_Homo sapiens_hsa049100.38621075
91Huntingtons disease_Homo sapiens_hsa050160.38161690
92Autoimmune thyroid disease_Homo sapiens_hsa053200.37505933
93Glucagon signaling pathway_Homo sapiens_hsa049220.35613506
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34819371
95Linoleic acid metabolism_Homo sapiens_hsa005910.33831045
96One carbon pool by folate_Homo sapiens_hsa006700.33292596
97* cAMP signaling pathway_Homo sapiens_hsa040240.32786007
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31799818
99Cardiac muscle contraction_Homo sapiens_hsa042600.30398735
100Non-homologous end-joining_Homo sapiens_hsa034500.29943860
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28310350
102Estrogen signaling pathway_Homo sapiens_hsa049150.27890500
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.27545466
104Renin-angiotensin system_Homo sapiens_hsa046140.27180849
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.26951353
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26488486
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25874921
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.25810678
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25467471
110Circadian entrainment_Homo sapiens_hsa047130.25272522
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24807998
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24690272
113Complement and coagulation cascades_Homo sapiens_hsa046100.24022374
114Biosynthesis of amino acids_Homo sapiens_hsa012300.24016026
115VEGF signaling pathway_Homo sapiens_hsa043700.23957217
116Focal adhesion_Homo sapiens_hsa045100.23613229
117Hepatitis C_Homo sapiens_hsa051600.23195446
118Metabolic pathways_Homo sapiens_hsa011000.22452202
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22062024
120Platelet activation_Homo sapiens_hsa046110.20761578
121Acute myeloid leukemia_Homo sapiens_hsa052210.19259917
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19231008
123ECM-receptor interaction_Homo sapiens_hsa045120.18354621
124Lysosome_Homo sapiens_hsa041420.16128191
125Prion diseases_Homo sapiens_hsa050200.15008877
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13759107
127Proteoglycans in cancer_Homo sapiens_hsa052050.13148964
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.13070903
129Chemical carcinogenesis_Homo sapiens_hsa052040.12521535
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.11885516
131Cocaine addiction_Homo sapiens_hsa050300.11871360
132Dopaminergic synapse_Homo sapiens_hsa047280.10677553
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10440062
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10131035
135Oxytocin signaling pathway_Homo sapiens_hsa049210.09925641
136Arginine biosynthesis_Homo sapiens_hsa002200.09686448
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.09314163
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.06003041
139Pancreatic cancer_Homo sapiens_hsa052120.05330678
140Thyroid cancer_Homo sapiens_hsa052160.05118824
141Chronic myeloid leukemia_Homo sapiens_hsa052200.04982839
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04857549
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.04466649
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.04165847
145Amoebiasis_Homo sapiens_hsa051460.03713989
146Phagosome_Homo sapiens_hsa041450.03255616
147Pertussis_Homo sapiens_hsa051330.02957424
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02509689
149Glutathione metabolism_Homo sapiens_hsa004800.01894288
150Histidine metabolism_Homo sapiens_hsa003400.01592707
151Alzheimers disease_Homo sapiens_hsa050100.01386043
152Rap1 signaling pathway_Homo sapiens_hsa040150.00261928
153Morphine addiction_Homo sapiens_hsa050320.00133235
154Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0109668
155HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0075415
156Parkinsons disease_Homo sapiens_hsa05012-0.0009921

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