MC3R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)4.50659775
2dopamine transport (GO:0015872)4.31776554
3regulation of T-helper 1 cell differentiation (GO:0045625)4.18451961
4G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.15898181
5GTP biosynthetic process (GO:0006183)3.89049848
6neuron cell-cell adhesion (GO:0007158)3.85334241
7postsynaptic membrane organization (GO:0001941)3.74726279
8presynaptic membrane assembly (GO:0097105)3.73845702
9eosinophil chemotaxis (GO:0048245)3.72125845
10regulation of feeding behavior (GO:0060259)3.65468433
11adult feeding behavior (GO:0008343)3.61495424
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59532047
13startle response (GO:0001964)3.54352123
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49115880
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.45927977
16opioid receptor signaling pathway (GO:0038003)3.34685205
17positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33453200
18eosinophil migration (GO:0072677)3.29892893
19regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.13062499
20transmission of nerve impulse (GO:0019226)3.12807588
21regulation of glutamate secretion (GO:0014048)3.10238837
22presynaptic membrane organization (GO:0097090)3.08519679
23negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04267841
24response to histamine (GO:0034776)3.01893251
25regulation of glutamate receptor signaling pathway (GO:1900449)3.01194033
26vocalization behavior (GO:0071625)3.00399081
27positive regulation of action potential (GO:0045760)2.96908957
28UTP biosynthetic process (GO:0006228)2.96666789
29ionotropic glutamate receptor signaling pathway (GO:0035235)2.95747537
30positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.94923025
31platelet dense granule organization (GO:0060155)2.92398953
32axonemal dynein complex assembly (GO:0070286)2.89432463
33neuronal action potential propagation (GO:0019227)2.88664184
34detection of other organism (GO:0098543)2.88085272
35positive regulation of dendritic spine morphogenesis (GO:0061003)2.87918284
36cellular response to exogenous dsRNA (GO:0071360)2.87760473
37nucleoside diphosphate phosphorylation (GO:0006165)2.87099194
38positive regulation of cellular amide metabolic process (GO:0034250)2.86316264
39negative regulation of amino acid transport (GO:0051956)2.84760753
40catecholamine transport (GO:0051937)2.83030935
41superoxide anion generation (GO:0042554)2.81818678
42positive regulation of monocyte chemotaxis (GO:0090026)2.80264091
43purinergic nucleotide receptor signaling pathway (GO:0035590)2.78779732
44auditory behavior (GO:0031223)2.78587560
45cellular response to ammonium ion (GO:0071242)2.77655823
46positive regulation of amino acid transport (GO:0051957)2.77064662
47microglial cell activation (GO:0001774)2.76792207
48ganglioside metabolic process (GO:0001573)2.76237595
49inner ear receptor stereocilium organization (GO:0060122)2.75352578
50regulation of memory T cell differentiation (GO:0043380)2.70704095
51positive regulation of T-helper cell differentiation (GO:0045624)2.70318431
52gamma-aminobutyric acid signaling pathway (GO:0007214)2.69532696
53neurotransmitter-gated ion channel clustering (GO:0072578)2.68351211
54monocyte chemotaxis (GO:0002548)2.68025384
55mechanosensory behavior (GO:0007638)2.65835738
56positive regulation of synapse assembly (GO:0051965)2.64900800
57positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.64755352
58axoneme assembly (GO:0035082)2.63121090
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62109380
60interferon-gamma production (GO:0032609)2.61049477
61dendritic cell chemotaxis (GO:0002407)2.60887404
62cilium movement (GO:0003341)2.59081333
63UTP metabolic process (GO:0046051)2.58591855
64response to peptidoglycan (GO:0032494)2.56814273
65CTP biosynthetic process (GO:0006241)2.56145706
66CTP metabolic process (GO:0046036)2.56145706
67neuropeptide signaling pathway (GO:0007218)2.55982373
68negative regulation of cAMP-mediated signaling (GO:0043951)2.55476412
69synaptic transmission, glutamatergic (GO:0035249)2.54252417
70glutamate receptor signaling pathway (GO:0007215)2.53897091
71negative regulation of amine transport (GO:0051953)2.53033418
72cranial nerve structural organization (GO:0021604)2.50323147
73regulation of T cell cytokine production (GO:0002724)2.50300320
74cellular response to interferon-beta (GO:0035458)2.49534205
75regulation of phospholipase A2 activity (GO:0032429)2.47095147
76positive regulation of T-helper 1 type immune response (GO:0002827)2.46929075
77protein localization to synapse (GO:0035418)2.46363806
78chondroitin sulfate catabolic process (GO:0030207)2.44645138
79regulation of synaptic transmission, glutamatergic (GO:0051966)2.43352762
80cAMP catabolic process (GO:0006198)2.42508822
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.41255122
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.40579603
83respiratory chain complex IV assembly (GO:0008535)2.40108503
84left/right axis specification (GO:0070986)2.39431631
85regulation of synaptic vesicle exocytosis (GO:2000300)2.39220149
86regulation of T-helper 1 type immune response (GO:0002825)2.38833266
87negative regulation of mast cell activation (GO:0033004)2.38407486
88regulation of action potential (GO:0098900)2.38192333
89G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.37959104
90positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.37846327
91regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.37846327
92negative regulation of catecholamine secretion (GO:0033604)2.37326575
93regulation of synaptic vesicle transport (GO:1902803)2.37062136
94oligosaccharide catabolic process (GO:0009313)2.36252090
95phagosome maturation (GO:0090382)2.36149625
96serotonin receptor signaling pathway (GO:0007210)2.35399081
97detection of bacterium (GO:0016045)2.33946062
98histamine secretion (GO:0001821)2.33787060
99positive regulation of interleukin-10 production (GO:0032733)2.33547598
100guanosine-containing compound biosynthetic process (GO:1901070)2.32570153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.95339248
2GBX2_23144817_ChIP-Seq_PC3_Human3.85441279
3TAF15_26573619_Chip-Seq_HEK293_Human3.21960096
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.84561519
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.54324760
6* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51078649
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30824765
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29662662
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18233521
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16960069
11AR_21572438_ChIP-Seq_LNCaP_Human2.09898270
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09561870
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08632510
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07490332
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06594917
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05934571
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04022171
18* P300_19829295_ChIP-Seq_ESCs_Human1.99810409
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.96527943
20IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96417972
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.96416121
22RNF2_27304074_Chip-Seq_NSC_Mouse1.93078663
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87831835
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.87348610
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86973960
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86679251
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80338493
28* ER_23166858_ChIP-Seq_MCF-7_Human1.79361996
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78635971
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73996092
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72187401
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72187401
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.71655550
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70868072
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.67306594
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65708860
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63399703
38* NANOG_18555785_Chip-Seq_ESCs_Mouse1.60792120
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58881870
40* REST_21632747_ChIP-Seq_MESCs_Mouse1.57909460
41SMAD4_21799915_ChIP-Seq_A2780_Human1.57285497
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.57093609
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55676691
44* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55672316
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53930466
46IRF1_19129219_ChIP-ChIP_H3396_Human1.53603567
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50713019
48* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49145628
49IGF1R_20145208_ChIP-Seq_DFB_Human1.48562935
50* E2F1_18555785_Chip-Seq_ESCs_Mouse1.47218487
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.44792289
52FUS_26573619_Chip-Seq_HEK293_Human1.43690804
53* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39394147
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38288720
55* STAT3_18555785_Chip-Seq_ESCs_Mouse1.38046104
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.37481159
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.37480179
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.36984007
59AR_25329375_ChIP-Seq_VCAP_Human1.36444048
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35992826
61* P53_22387025_ChIP-Seq_ESCs_Mouse1.35445177
62EWS_26573619_Chip-Seq_HEK293_Human1.34475694
63* NMYC_18555785_Chip-Seq_ESCs_Mouse1.33516198
64* P300_18555785_Chip-Seq_ESCs_Mouse1.33416627
65* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32904710
66* CMYC_18555785_Chip-Seq_ESCs_Mouse1.32640119
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32263316
68DROSHA_22980978_ChIP-Seq_HELA_Human1.31630756
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29979676
70* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29258567
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28910688
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.27298338
73RUNX2_22187159_ChIP-Seq_PCA_Human1.25193485
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22899744
75* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22422362
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.22059053
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21937003
78SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21663062
79* SOX2_18555785_Chip-Seq_ESCs_Mouse1.21323067
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19241814
81VDR_22108803_ChIP-Seq_LS180_Human1.18849416
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17958987
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17551864
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17551864
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16706916
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16504867
87PU1_27457419_Chip-Seq_LIVER_Mouse1.16062325
88* CTCF_18555785_Chip-Seq_ESCs_Mouse1.15290692
89* OCT4_18555785_Chip-Seq_ESCs_Mouse1.14197491
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.13816530
91* KLF4_18555785_Chip-Seq_ESCs_Mouse1.12938504
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12784970
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12716686
94* ZFX_18555785_Chip-Seq_ESCs_Mouse1.10396254
95KDM2B_26808549_Chip-Seq_REH_Human1.10302471
96TCF4_23295773_ChIP-Seq_U87_Human1.10131538
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09317749
98STAT3_23295773_ChIP-Seq_U87_Human1.09292855
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06528873
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06009974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.25484157
2MP0003880_abnormal_central_pattern3.96525954
3MP0005645_abnormal_hypothalamus_physiol3.61965563
4MP0002822_catalepsy3.04435719
5MP0006276_abnormal_autonomic_nervous2.80325625
6MP0001188_hyperpigmentation2.62507816
7MP0000566_synostosis2.60069647
8MP0001968_abnormal_touch/_nociception2.54643487
9MP0005423_abnormal_somatic_nervous2.44626643
10MP0009046_muscle_twitch2.29430081
11MP0009745_abnormal_behavioral_response2.25547703
12MP0006292_abnormal_olfactory_placode2.24968006
13MP0004142_abnormal_muscle_tone2.18804857
14MP0001486_abnormal_startle_reflex2.14020456
15MP0003724_increased_susceptibility_to2.11878149
16MP0003635_abnormal_synaptic_transmissio2.04052284
17MP0002572_abnormal_emotion/affect_behav2.03912709
18MP0005646_abnormal_pituitary_gland1.98077816
19MP0002736_abnormal_nociception_after1.93877807
20MP0001502_abnormal_circadian_rhythm1.93146353
21MP0001501_abnormal_sleep_pattern1.91663175
22MP0010386_abnormal_urinary_bladder1.84846325
23MP0003787_abnormal_imprinting1.84761847
24MP0001529_abnormal_vocalization1.84271634
25MP0003121_genomic_imprinting1.81980272
26MP0002064_seizures1.80238099
27MP0002272_abnormal_nervous_system1.79911209
28MP0001440_abnormal_grooming_behavior1.75033215
29MP0006082_CNS_inflammation1.73944052
30MP0001984_abnormal_olfaction1.71212953
31MP0009785_altered_susceptibility_to1.68029173
32MP0001835_abnormal_antigen_presentation1.67237176
33MP0001661_extended_life_span1.66782529
34MP0005623_abnormal_meninges_morphology1.65925708
35MP0002063_abnormal_learning/memory/cond1.65833543
36MP0002557_abnormal_social/conspecific_i1.64717747
37MP0002148_abnormal_hypersensitivity_rea1.57533553
38MP0004859_abnormal_synaptic_plasticity1.52182513
39MP0005535_abnormal_body_temperature1.50526054
40MP0002067_abnormal_sensory_capabilities1.47259815
41MP0005386_behavior/neurological_phenoty1.45924404
42MP0004924_abnormal_behavior1.45924404
43MP0001764_abnormal_homeostasis1.45269389
44MP0002638_abnormal_pupillary_reflex1.44892688
45MP0009697_abnormal_copulation1.39852878
46MP0002277_abnormal_respiratory_mucosa1.37016707
47MP0003690_abnormal_glial_cell1.35066238
48MP0002735_abnormal_chemical_nociception1.34892348
49MP0005671_abnormal_response_to1.31019703
50MP0002876_abnormal_thyroid_physiology1.30148160
51MP0001905_abnormal_dopamine_level1.27048967
52MP0002734_abnormal_mechanical_nocicepti1.23557333
53MP0005670_abnormal_white_adipose1.19462816
54MP0002102_abnormal_ear_morphology1.18909528
55MP0003868_abnormal_feces_composition1.16894377
56* MP0003959_abnormal_lean_body1.15563453
57MP0003172_abnormal_lysosome_physiology1.14005716
58MP0005000_abnormal_immune_tolerance1.12226321
59MP0001664_abnormal_digestion1.12030801
60MP0005387_immune_system_phenotype1.10410907
61MP0001790_abnormal_immune_system1.10410907
62MP0002184_abnormal_innervation1.10080464
63MP0001970_abnormal_pain_threshold1.08843562
64MP0002419_abnormal_innate_immunity1.07984525
65MP0004742_abnormal_vestibular_system1.06730243
66MP0000631_abnormal_neuroendocrine_gland1.03724553
67MP0005409_darkened_coat_color1.03220973
68MP0000026_abnormal_inner_ear1.03103592
69MP0005551_abnormal_eye_electrophysiolog0.97181920
70MP0009764_decreased_sensitivity_to0.96781707
71MP0002733_abnormal_thermal_nociception0.95874644
72MP0005379_endocrine/exocrine_gland_phen0.95426555
73MP0001963_abnormal_hearing_physiology0.93393345
74MP0002693_abnormal_pancreas_physiology0.93014607
75MP0002396_abnormal_hematopoietic_system0.92394503
76MP0001986_abnormal_taste_sensitivity0.88093996
77MP0004145_abnormal_muscle_electrophysio0.84659249
78MP0005310_abnormal_salivary_gland0.83719229
79MP0002938_white_spotting0.83056450
80MP0000538_abnormal_urinary_bladder0.81088780
81MP0005025_abnormal_response_to0.80446949
82MP0008260_abnormal_autophagy0.79920416
83MP0004270_analgesia0.79020795
84MP0005464_abnormal_platelet_physiology0.78636154
85* MP0002066_abnormal_motor_capabilities/c0.74148191
86MP0003303_peritoneal_inflammation0.71137612
87* MP0005448_abnormal_energy_balance0.69512936
88MP0003436_decreased_susceptibility_to0.69285794
89MP0002723_abnormal_immune_serum0.67402940
90MP0004883_abnormal_blood_vessel0.66408567
91MP0002452_abnormal_antigen_presenting0.65870616
92MP0008874_decreased_physiological_sensi0.65448125
93MP0002882_abnormal_neuron_morphology0.65362681
94MP0000465_gastrointestinal_hemorrhage0.63117108
95MP0003879_abnormal_hair_cell0.63032272
96MP0002752_abnormal_somatic_nervous0.61306934
97MP0000778_abnormal_nervous_system0.59183098
98MP0001819_abnormal_immune_cell0.57930762
99MP0005084_abnormal_gallbladder_morpholo0.57241049
100MP0002909_abnormal_adrenal_gland0.56327409

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)5.85638781
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.48225521
3Absent/shortened dynein arms (HP:0200106)5.48225521
4Abnormal respiratory motile cilium physiology (HP:0012261)4.76310416
5Abnormal respiratory epithelium morphology (HP:0012253)4.68021739
6Abnormal respiratory motile cilium morphology (HP:0005938)4.68021739
7Polyphagia (HP:0002591)4.52567873
8Febrile seizures (HP:0002373)4.10576055
9Focal motor seizures (HP:0011153)3.93574518
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.82292608
11Abnormal hair whorl (HP:0010721)3.55854783
12Optic neuritis (HP:0100653)3.38596466
13Retrobulbar optic neuritis (HP:0100654)3.38596466
14Hypothermia (HP:0002045)3.02118467
15Epileptic encephalopathy (HP:0200134)2.94550332
16Blue irides (HP:0000635)2.93675149
17Sleep apnea (HP:0010535)2.83000657
18Rhinitis (HP:0012384)2.77717635
19Agitation (HP:0000713)2.73785341
20Atonic seizures (HP:0010819)2.67829339
213-Methylglutaconic aciduria (HP:0003535)2.64956794
22Recurrent sinusitis (HP:0011108)2.60831779
23Parakeratosis (HP:0001036)2.55924266
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.53854176
25Prostate neoplasm (HP:0100787)2.52093252
26Oligomenorrhea (HP:0000876)2.50958713
27Abnormal eating behavior (HP:0100738)2.50464327
28Fair hair (HP:0002286)2.48499408
29J-shaped sella turcica (HP:0002680)2.47292257
30Orchitis (HP:0100796)2.44311523
31Renal Fanconi syndrome (HP:0001994)2.40182177
32Myositis (HP:0100614)2.38843083
33Failure to thrive in infancy (HP:0001531)2.37434400
34Dry hair (HP:0011359)2.36875467
35Abnormality of calcium-phosphate metabolism (HP:0100530)2.35892793
36Osteomalacia (HP:0002749)2.35602299
37Joint hemorrhage (HP:0005261)2.35403453
38Prolonged partial thromboplastin time (HP:0003645)2.31822994
39Progressive cerebellar ataxia (HP:0002073)2.28259414
40Focal seizures (HP:0007359)2.27249882
41Hip dysplasia (HP:0001385)2.23785082
42Abnormality of the labia minora (HP:0012880)2.20871007
43Absence seizures (HP:0002121)2.16450508
44Abnormality of secondary sexual hair (HP:0009888)2.16343385
45Abnormality of the axillary hair (HP:0100134)2.16343385
46Protruding tongue (HP:0010808)2.15172127
47Increased hepatocellular lipid droplets (HP:0006565)2.13599130
48Lipid accumulation in hepatocytes (HP:0006561)2.11879920
49Conjugated hyperbilirubinemia (HP:0002908)2.11195536
50Hyperventilation (HP:0002883)2.10755073
51Recurrent abscess formation (HP:0002722)2.09126179
52Abnormality of alanine metabolism (HP:0010916)2.08795754
53Hyperalaninemia (HP:0003348)2.08795754
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08795754
55Abnormality of the parietal bone (HP:0002696)2.06742114
56White forelock (HP:0002211)2.06625743
57Patchy hypopigmentation of hair (HP:0011365)2.06236908
58Prolonged bleeding time (HP:0003010)2.04914977
59Poor suck (HP:0002033)2.03578362
60Generalized tonic-clonic seizures (HP:0002069)2.03375854
61Esotropia (HP:0000565)2.01415940
62Dialeptic seizures (HP:0011146)2.00162082
63Increased IgM level (HP:0003496)1.98773118
64Menstrual irregularities (HP:0000858)1.98247854
65Generalized hypopigmentation of hair (HP:0011358)1.97989422
66Spinal canal stenosis (HP:0003416)1.97907048
67Narrow nasal bridge (HP:0000446)1.92866960
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91800042
69Bronchiectasis (HP:0002110)1.90046357
70Nephronophthisis (HP:0000090)1.88410542
71Deformed sella turcica (HP:0002681)1.85441201
72Cerebral palsy (HP:0100021)1.85414346
73Abnormality of the prostate (HP:0008775)1.84588231
74Chronic hepatic failure (HP:0100626)1.84406722
75Encephalitis (HP:0002383)1.84317319
76Attenuation of retinal blood vessels (HP:0007843)1.80361714
77Chronic diarrhea (HP:0002028)1.79910808
78Chronic obstructive pulmonary disease (HP:0006510)1.78870812
79Obstructive lung disease (HP:0006536)1.78870812
80Keratoconjunctivitis sicca (HP:0001097)1.78202449
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77701897
82Broad-based gait (HP:0002136)1.77369329
83Recurrent gram-negative bacterial infections (HP:0005420)1.74804387
84Mediastinal lymphadenopathy (HP:0100721)1.73896492
85Flared iliac wings (HP:0002869)1.72830017
86Recurrent pneumonia (HP:0006532)1.72105312
87Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70886533
88Keratoconjunctivitis (HP:0001096)1.70730543
89Abnormality of renal resorption (HP:0011038)1.69848659
90Optic disc pallor (HP:0000543)1.69792241
91Infantile muscular hypotonia (HP:0008947)1.68530617
92Chronic sinusitis (HP:0011109)1.67288371
93Renal tubular dysfunction (HP:0000124)1.66286867
94Septo-optic dysplasia (HP:0100842)1.66168231
95Broad face (HP:0000283)1.65033172
96Aplasia/Hypoplasia of the fovea (HP:0008060)1.65027417
97Hypoplasia of the fovea (HP:0007750)1.65027417
98Midline defect of the nose (HP:0004122)1.61296445
99Acne (HP:0001061)1.58480098
100Hyperphosphatemia (HP:0002905)1.57441469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.26794975
2TIE13.94403284
3GRK72.97606763
4ADRBK22.71024540
5NTRK32.65025067
6MAP3K122.49878694
7TNIK2.49465230
8MAP3K132.19913827
9MAP3K142.14288717
10GRK12.05482100
11STK162.04220868
12TNK21.92814445
13AKT31.89713466
14INSRR1.84647439
15MAP2K71.81964444
16IRAK31.81139842
17IRAK41.79369577
18TXK1.78513900
19IRAK21.71233825
20MAPK131.62494809
21EIF2AK21.60048845
22IRAK11.55541913
23CAMKK21.44772163
24YES11.40363591
25ARAF1.39105623
26TEC1.32325737
27ERBB31.19533082
28CDK31.18692127
29CDK191.12909046
30PIK3CG1.11617446
31KIT1.10187915
32NEK61.09483474
33TGFBR21.07869357
34BMPR21.04822995
35NUAK11.04740105
36MAP3K90.99745990
37CSNK1G30.98848849
38TSSK60.97349993
39PINK10.95774897
40VRK10.92865161
41BMPR1B0.92617058
42PRKCE0.92471084
43CSNK1G10.88021503
44CAMK1D0.81393167
45CAMK2A0.79954169
46CSF1R0.79712229
47MAP2K40.78707674
48ERBB40.76881821
49MKNK20.75901115
50MARK10.75831118
51IKBKB0.75272481
52STK380.72603914
53PRKCG0.70722622
54BRAF0.70412881
55PLK20.69716446
56PIM20.68744998
57CSNK1G20.68577312
58MAPK150.68265102
59BMX0.67451791
60SGK20.66148140
61CSNK1A1L0.65993004
62ADRBK10.65593848
63SIK30.65582769
64ZAK0.65198092
65SYK0.64419783
66NTRK20.59527348
67MUSK0.59520804
68PKN10.55955314
69CAMK10.55270403
70EPHA40.53437226
71PRPF4B0.52398668
72FES0.49507475
73MATK0.47147727
74MAP2K60.46705062
75MOS0.46516208
76SGK10.46380615
77PRKG10.46307283
78MAP3K40.45944206
79GRK50.45185940
80CDK80.44784752
81MAPK70.43813535
82PRKACA0.43673900
83RPS6KA20.43070459
84OXSR10.42587280
85MAPK120.42292786
86JAK10.41311331
87WNK30.41033246
88CAMK2B0.40833761
89CAMK40.39958248
90PRKCA0.39802402
91CAMK2G0.38605488
92MINK10.36400960
93PRKCQ0.36216331
94PRKCD0.36182677
95NLK0.35944017
96CDK50.35640407
97LATS10.35373941
98CDK90.35308590
99LYN0.35304194
100CAMKK10.33943487

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.12121278
2Graft-versus-host disease_Homo sapiens_hsa053323.50353289
3Rheumatoid arthritis_Homo sapiens_hsa053232.85916274
4Morphine addiction_Homo sapiens_hsa050322.61407802
5* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.54494540
6Type I diabetes mellitus_Homo sapiens_hsa049402.26593046
7GABAergic synapse_Homo sapiens_hsa047272.24402565
8Taste transduction_Homo sapiens_hsa047422.24355363
9Allograft rejection_Homo sapiens_hsa053302.19789242
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18095594
11Collecting duct acid secretion_Homo sapiens_hsa049662.16927155
12Olfactory transduction_Homo sapiens_hsa047401.98870910
13Oxidative phosphorylation_Homo sapiens_hsa001901.97188156
14Synaptic vesicle cycle_Homo sapiens_hsa047211.82525846
15Autoimmune thyroid disease_Homo sapiens_hsa053201.64079273
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63542728
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62437306
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.56112322
19Cocaine addiction_Homo sapiens_hsa050301.53168831
20Serotonergic synapse_Homo sapiens_hsa047261.52176741
21Circadian entrainment_Homo sapiens_hsa047131.51161368
22Glutamatergic synapse_Homo sapiens_hsa047241.50891807
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.46888561
24Staphylococcus aureus infection_Homo sapiens_hsa051501.45989757
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45785527
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43780549
27Parkinsons disease_Homo sapiens_hsa050121.35157779
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33912221
29Renin secretion_Homo sapiens_hsa049241.33879892
30Insulin secretion_Homo sapiens_hsa049111.32962556
31Salivary secretion_Homo sapiens_hsa049701.26306752
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25387033
33Calcium signaling pathway_Homo sapiens_hsa040201.22884403
34Amphetamine addiction_Homo sapiens_hsa050311.19520413
35Ovarian steroidogenesis_Homo sapiens_hsa049131.17896280
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15818750
37Phototransduction_Homo sapiens_hsa047441.14998407
38Vibrio cholerae infection_Homo sapiens_hsa051101.12734937
39Protein export_Homo sapiens_hsa030601.11870576
40Malaria_Homo sapiens_hsa051441.03632945
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99244562
42Prion diseases_Homo sapiens_hsa050200.98274846
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97769703
44Alzheimers disease_Homo sapiens_hsa050100.95092573
45Phagosome_Homo sapiens_hsa041450.91794825
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89998297
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89590114
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89515429
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88235656
50Gastric acid secretion_Homo sapiens_hsa049710.86851242
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83499744
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.83334469
53Cholinergic synapse_Homo sapiens_hsa047250.80966507
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79891840
55ABC transporters_Homo sapiens_hsa020100.78308934
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.77248848
57Hematopoietic cell lineage_Homo sapiens_hsa046400.75150731
58Cardiac muscle contraction_Homo sapiens_hsa042600.74027591
59Leishmaniasis_Homo sapiens_hsa051400.73977248
60Dopaminergic synapse_Homo sapiens_hsa047280.73338666
61African trypanosomiasis_Homo sapiens_hsa051430.71842501
62Dorso-ventral axis formation_Homo sapiens_hsa043200.71598157
63Huntingtons disease_Homo sapiens_hsa050160.71407503
64Long-term depression_Homo sapiens_hsa047300.71199015
65cAMP signaling pathway_Homo sapiens_hsa040240.70825355
66Oxytocin signaling pathway_Homo sapiens_hsa049210.70742807
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70314649
68Pertussis_Homo sapiens_hsa051330.67696882
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67546729
70Chemokine signaling pathway_Homo sapiens_hsa040620.65609204
71Ether lipid metabolism_Homo sapiens_hsa005650.64759209
72Fatty acid elongation_Homo sapiens_hsa000620.60413117
73Measles_Homo sapiens_hsa051620.60098547
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.59596261
75Tuberculosis_Homo sapiens_hsa051520.58832061
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56778249
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56519880
78Asthma_Homo sapiens_hsa053100.56260730
79Sphingolipid metabolism_Homo sapiens_hsa006000.54138880
80Legionellosis_Homo sapiens_hsa051340.52539831
81Dilated cardiomyopathy_Homo sapiens_hsa054140.49349925
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.48271454
83Bile secretion_Homo sapiens_hsa049760.45510466
84Complement and coagulation cascades_Homo sapiens_hsa046100.44344025
85PPAR signaling pathway_Homo sapiens_hsa033200.43338658
86Arachidonic acid metabolism_Homo sapiens_hsa005900.42961662
87Gap junction_Homo sapiens_hsa045400.42056958
88Other glycan degradation_Homo sapiens_hsa005110.39729210
89Estrogen signaling pathway_Homo sapiens_hsa049150.37934843
90Vitamin digestion and absorption_Homo sapiens_hsa049770.37009161
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34725935
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34695860
93Starch and sucrose metabolism_Homo sapiens_hsa005000.34598059
94Axon guidance_Homo sapiens_hsa043600.33620201
95Long-term potentiation_Homo sapiens_hsa047200.32917654
96Melanogenesis_Homo sapiens_hsa049160.32804145
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31868097
98Peroxisome_Homo sapiens_hsa041460.31012733
99Osteoclast differentiation_Homo sapiens_hsa043800.30287841
100Purine metabolism_Homo sapiens_hsa002300.29153873

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