MC4R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.48790829
2cellular potassium ion homeostasis (GO:0030007)5.79964593
3neuron cell-cell adhesion (GO:0007158)5.74476526
4regulation of synapse structural plasticity (GO:0051823)5.13023488
5nucleobase catabolic process (GO:0046113)5.05664633
6establishment of mitochondrion localization (GO:0051654)5.03018943
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.02316512
8glutamate receptor signaling pathway (GO:0007215)4.90674560
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90096303
10neuron recognition (GO:0008038)4.89015561
11vocalization behavior (GO:0071625)4.80172885
12gamma-aminobutyric acid transport (GO:0015812)4.75150899
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.71586072
14potassium ion homeostasis (GO:0055075)4.68597285
15protein localization to synapse (GO:0035418)4.53375937
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37629024
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.37362976
18regulation of glutamate receptor signaling pathway (GO:1900449)4.35711099
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.29827187
20positive regulation of synapse maturation (GO:0090129)4.25876221
21locomotory exploration behavior (GO:0035641)4.23434002
22neuronal ion channel clustering (GO:0045161)4.21397224
23exploration behavior (GO:0035640)4.21383195
24axonal fasciculation (GO:0007413)4.18058028
25regulation of glutamate secretion (GO:0014048)4.16004765
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.14677730
27synaptic vesicle exocytosis (GO:0016079)4.13778702
28transmission of nerve impulse (GO:0019226)4.10088499
29presynaptic membrane assembly (GO:0097105)4.09826505
30dendritic spine morphogenesis (GO:0060997)4.08473334
31response to histamine (GO:0034776)4.06027634
32glycosphingolipid biosynthetic process (GO:0006688)4.04228751
33mitochondrion transport along microtubule (GO:0047497)4.03459386
34establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.03459386
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00227906
36postsynaptic membrane organization (GO:0001941)3.99311473
37synaptic transmission, glutamatergic (GO:0035249)3.97449332
38regulation of axon extension involved in axon guidance (GO:0048841)3.91266073
39regulation of synaptic vesicle exocytosis (GO:2000300)3.86961795
40neuronal action potential propagation (GO:0019227)3.82387410
41neuron-neuron synaptic transmission (GO:0007270)3.79733127
42negative regulation of amino acid transport (GO:0051956)3.79588367
43presynaptic membrane organization (GO:0097090)3.76952659
44neurotransmitter-gated ion channel clustering (GO:0072578)3.71817391
45positive regulation of dendritic spine morphogenesis (GO:0061003)3.71660469
46positive regulation of synapse assembly (GO:0051965)3.71311995
47negative regulation of axon extension (GO:0030517)3.68946799
48membrane depolarization during action potential (GO:0086010)3.64420517
49layer formation in cerebral cortex (GO:0021819)3.63301624
50regulation of axon guidance (GO:1902667)3.61174095
51regulation of dendritic spine morphogenesis (GO:0061001)3.59915183
52behavioral defense response (GO:0002209)3.58978585
53behavioral fear response (GO:0001662)3.58978585
54retinal ganglion cell axon guidance (GO:0031290)3.55356450
55innervation (GO:0060384)3.54443100
56striatum development (GO:0021756)3.53916099
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53069781
58regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50390769
59fear response (GO:0042596)3.49241043
60neuron projection extension involved in neuron projection guidance (GO:1902284)3.46222655
61axon extension involved in axon guidance (GO:0048846)3.46222655
62long-term synaptic potentiation (GO:0060291)3.42637804
63dendritic spine organization (GO:0097061)3.42308049
64regulation of excitatory postsynaptic membrane potential (GO:0060079)3.42301637
65regulation of synapse maturation (GO:0090128)3.41784251
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39250607
67regulation of synaptic vesicle transport (GO:1902803)3.38204154
68regulation of vesicle fusion (GO:0031338)3.36732536
69mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33376725
70positive regulation of membrane potential (GO:0045838)3.33374558
71positive regulation of potassium ion transmembrane transport (GO:1901381)3.31786751
72regulation of postsynaptic membrane potential (GO:0060078)3.30449147
73positive regulation of dendritic spine development (GO:0060999)3.29297844
74synaptic vesicle docking involved in exocytosis (GO:0016081)3.28365748
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27827087
76positive regulation of mitochondrial fission (GO:0090141)3.25316348
77negative chemotaxis (GO:0050919)3.24498244
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24159310
79glutamate secretion (GO:0014047)3.23275269
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23044603
81regulation of neuronal synaptic plasticity (GO:0048168)3.22695110
82central nervous system projection neuron axonogenesis (GO:0021952)3.22125223
83ganglioside metabolic process (GO:0001573)3.18650052
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.16723838
85ATP synthesis coupled proton transport (GO:0015986)3.15435317
86energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15435317
87negative regulation of dendrite morphogenesis (GO:0050774)3.13608532
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13245044
89dendrite development (GO:0016358)3.12758642
90neurotransmitter secretion (GO:0007269)3.11071374
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07371636
92negative regulation of axon extension involved in axon guidance (GO:0048843)3.07005610
93dendrite morphogenesis (GO:0048813)3.06982637
94regulation of axon extension (GO:0030516)3.05466948
95regulation of synapse assembly (GO:0051963)3.04789740
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04674038
97regulation of dendritic spine development (GO:0060998)3.03978807
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03485701
99proline transport (GO:0015824)3.03122834
100cerebellar granule cell differentiation (GO:0021707)3.02902287
101neuron remodeling (GO:0016322)3.01611204
102regulation of synaptic plasticity (GO:0048167)3.01500745
103auditory behavior (GO:0031223)3.01436215
104regulation of axon regeneration (GO:0048679)3.00194143
105regulation of neuron projection regeneration (GO:0070570)3.00194143
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99485902
107long term synaptic depression (GO:0060292)2.99374719
108cochlea development (GO:0090102)2.97747042
109neurotransmitter catabolic process (GO:0042135)2.95848876
110detection of calcium ion (GO:0005513)2.95223637
111regulation of synaptic transmission, GABAergic (GO:0032228)2.94323672
112organelle transport along microtubule (GO:0072384)2.92399063
113protein polyglutamylation (GO:0018095)2.92199723
114histone arginine methylation (GO:0034969)2.92086602
115regulation of neurotransmitter levels (GO:0001505)2.91472554
116membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.91224231
117long-term memory (GO:0007616)2.90830930
118synapse assembly (GO:0007416)2.90816715
119positive regulation of amino acid transport (GO:0051957)2.87691784
120regulation of respiratory system process (GO:0044065)2.86873551
121membrane depolarization (GO:0051899)2.86381754
122adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86356633
123calcium-mediated signaling using intracellular calcium source (GO:0035584)2.86284458
124axon extension (GO:0048675)2.86103520
125regulation of synapse organization (GO:0050807)2.85818646
126alkaloid metabolic process (GO:0009820)2.84383886
127learning (GO:0007612)2.84214977
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.82800819
129synaptic vesicle endocytosis (GO:0048488)2.81930589
130startle response (GO:0001964)2.81857705
131cell migration in hindbrain (GO:0021535)2.80175414
132regulation of amino acid transport (GO:0051955)2.80147954
133neurotransmitter transport (GO:0006836)2.79913589
134synapse organization (GO:0050808)2.79662300
135inner ear receptor cell development (GO:0060119)2.79648244
136neuron projection extension (GO:1990138)2.78867729
137vesicle transport along microtubule (GO:0047496)2.78149138
138opioid receptor signaling pathway (GO:0038003)2.78102781
139positive regulation of neurotransmitter secretion (GO:0001956)2.78036199
140activation of protein kinase A activity (GO:0034199)2.77649629
141negative regulation of amine transport (GO:0051953)2.77135239
142synaptic vesicle maturation (GO:0016188)2.76575657
143adult walking behavior (GO:0007628)2.76281899
144sodium ion export (GO:0071436)2.76168911
145negative regulation of axon guidance (GO:1902668)2.75819910
146synaptic transmission, cholinergic (GO:0007271)2.74640525
147regulation of microtubule-based movement (GO:0060632)2.73573030
148C4-dicarboxylate transport (GO:0015740)2.71715666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.23169732
2GBX2_23144817_ChIP-Seq_PC3_Human4.12879562
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16783326
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07089906
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00469045
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.83883597
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.70990983
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68971948
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66311481
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57769084
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57496468
12TAF15_26573619_Chip-Seq_HEK293_Human2.56315753
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.49962099
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49175056
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49175056
16REST_21632747_ChIP-Seq_MESCs_Mouse2.45885898
17* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.44561370
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.41368831
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.40604834
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32239639
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30287073
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26429599
23* ZNF274_21170338_ChIP-Seq_K562_Hela2.16077811
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.12231074
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.09794202
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09024540
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.98460003
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94824132
29* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93602565
30AR_21572438_ChIP-Seq_LNCaP_Human1.90642042
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89271269
32* P300_19829295_ChIP-Seq_ESCs_Human1.87173685
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86882741
34* REST_18959480_ChIP-ChIP_MESCs_Mouse1.85582159
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.82580666
36FUS_26573619_Chip-Seq_HEK293_Human1.82266310
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80998956
38SMAD4_21799915_ChIP-Seq_A2780_Human1.78124272
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76634107
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68877369
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60922549
42* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59385786
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.56291736
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55851647
45DROSHA_22980978_ChIP-Seq_HELA_Human1.55533416
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.53440493
47RNF2_27304074_Chip-Seq_NSC_Mouse1.49755616
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49670824
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48761181
50IGF1R_20145208_ChIP-Seq_DFB_Human1.47677472
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45999816
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43914859
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.43789440
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43664431
55VDR_22108803_ChIP-Seq_LS180_Human1.42658624
56* AR_25329375_ChIP-Seq_VCAP_Human1.42151052
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37971510
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33691985
59* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33589092
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32717487
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.28939204
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27998542
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.27378047
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26599449
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26124912
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.24024846
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.23839131
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.21265332
69JUN_21703547_ChIP-Seq_K562_Human1.14863603
70* RUNX2_22187159_ChIP-Seq_PCA_Human1.13098642
71TP53_18474530_ChIP-ChIP_U2OS_Human1.12643397
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12268376
73* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12195915
74ER_23166858_ChIP-Seq_MCF-7_Human1.10848369
75CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08420511
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.07868869
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07792376
78TP53_16413492_ChIP-PET_HCT116_Human1.07761923
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06917034
80* STAT3_23295773_ChIP-Seq_U87_Human1.05020032
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04939857
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04828131
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04747816
84TCF4_23295773_ChIP-Seq_U87_Human1.04347086
85EWS_26573619_Chip-Seq_HEK293_Human1.04334887
86AHR_22903824_ChIP-Seq_MCF-7_Human1.04292209
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.04077658
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03678406
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03383727
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.03308820
91* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02639727
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02347440
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02347440
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01790975
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01017558
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00796516
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00371487
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00076742
99* BCAT_22108803_ChIP-Seq_LS180_Human0.98243718
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97991332
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97811629
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97750185
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97473101
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96530925
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95097496
106AR_19668381_ChIP-Seq_PC3_Human0.95040831
107* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94168673
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94110967
109KDM2B_26808549_Chip-Seq_REH_Human0.93097061
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92444918
111P53_22387025_ChIP-Seq_ESCs_Mouse0.91374398
112ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90883011
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89109798
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88963895
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87866017
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87585072
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.87365802
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86497336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.54717981
2MP0004859_abnormal_synaptic_plasticity4.92875534
3MP0003122_maternal_imprinting3.70669048
4MP0003635_abnormal_synaptic_transmissio3.62470873
5MP0004270_analgesia3.30515475
6MP0009745_abnormal_behavioral_response3.06925523
7MP0002063_abnormal_learning/memory/cond3.01245999
8MP0005645_abnormal_hypothalamus_physiol2.98944783
9MP0001968_abnormal_touch/_nociception2.80080395
10MP0002572_abnormal_emotion/affect_behav2.71808365
11MP0006276_abnormal_autonomic_nervous2.70599241
12MP0002064_seizures2.67748644
13MP0002736_abnormal_nociception_after2.59741738
14MP0001440_abnormal_grooming_behavior2.47413761
15MP0002272_abnormal_nervous_system2.39989459
16MP0009046_muscle_twitch2.32449277
17MP0005423_abnormal_somatic_nervous2.26392806
18MP0003787_abnormal_imprinting2.22482649
19MP0002734_abnormal_mechanical_nocicepti2.21199776
20MP0001188_hyperpigmentation2.17964435
21MP0002735_abnormal_chemical_nociception2.16252557
22MP0001501_abnormal_sleep_pattern2.15202961
23MP0001486_abnormal_startle_reflex2.12392528
24MP0002184_abnormal_innervation2.08933973
25MP0001529_abnormal_vocalization2.07996575
26MP0000778_abnormal_nervous_system2.04125481
27MP0009379_abnormal_foot_pigmentation2.01438289
28MP0002733_abnormal_thermal_nociception1.88019899
29MP0002067_abnormal_sensory_capabilities1.76548326
30MP0002837_dystrophic_cardiac_calcinosis1.74021550
31MP0001970_abnormal_pain_threshold1.71916739
32MP0003121_genomic_imprinting1.65937782
33MP0002557_abnormal_social/conspecific_i1.63216718
34MP0003329_amyloid_beta_deposits1.63090327
35MP0004858_abnormal_nervous_system1.51590846
36MP0001542_abnormal_bone_strength1.50948905
37MP0004924_abnormal_behavior1.50517176
38MP0005386_behavior/neurological_phenoty1.50517176
39MP0002909_abnormal_adrenal_gland1.49483816
40MP0005503_abnormal_tendon_morphology1.43269653
41MP0005187_abnormal_penis_morphology1.38612520
42MP0000955_abnormal_spinal_cord1.37945250
43MP0004142_abnormal_muscle_tone1.37265150
44MP0006072_abnormal_retinal_apoptosis1.34544720
45MP0002882_abnormal_neuron_morphology1.32695353
46* MP0002066_abnormal_motor_capabilities/c1.28614262
47MP0004811_abnormal_neuron_physiology1.26864647
48MP0005623_abnormal_meninges_morphology1.24435926
49MP0000631_abnormal_neuroendocrine_gland1.22789500
50MP0005409_darkened_coat_color1.19954682
51MP0005646_abnormal_pituitary_gland1.19568768
52MP0008569_lethality_at_weaning1.19334009
53MP0003123_paternal_imprinting1.17723398
54MP0001905_abnormal_dopamine_level1.17531305
55MP0003879_abnormal_hair_cell1.17446216
56MP0000751_myopathy1.16987788
57MP0005551_abnormal_eye_electrophysiolog1.13632962
58MP0001984_abnormal_olfaction1.12969412
59MP0002152_abnormal_brain_morphology1.09150725
60MP0004145_abnormal_muscle_electrophysio1.08850861
61* MP0001502_abnormal_circadian_rhythm1.07048755
62MP0004742_abnormal_vestibular_system1.06590262
63MP0008438_abnormal_cutaneous_collagen1.02520315
64MP0009780_abnormal_chondrocyte_physiolo1.02374149
65MP0004134_abnormal_chest_morphology1.02272484
66MP0002876_abnormal_thyroid_physiology1.02046580
67MP0004885_abnormal_endolymph0.99472661
68MP0002822_catalepsy0.95041868
69MP0002653_abnormal_ependyma_morphology0.94628331
70MP0008995_early_reproductive_senescence0.93721831
71MP0002229_neurodegeneration0.92598377
72MP0010386_abnormal_urinary_bladder0.92002126
73MP0003283_abnormal_digestive_organ0.90289153
74MP0005257_abnormal_intraocular_pressure0.89405765
75* MP0002069_abnormal_eating/drinking_beha0.87535908
76MP0001963_abnormal_hearing_physiology0.87430471
77MP0005379_endocrine/exocrine_gland_phen0.86800217
78MP0002752_abnormal_somatic_nervous0.86791698
79MP0000013_abnormal_adipose_tissue0.85941432
80MP0001299_abnormal_eye_distance/0.82264410
81MP0008877_abnormal_DNA_methylation0.82039186
82MP0004133_heterotaxia0.81173243
83MP0000049_abnormal_middle_ear0.81120741
84MP0006035_abnormal_mitochondrial_morpho0.80170727
85MP0004484_altered_response_of0.79342576
86MP0003631_nervous_system_phenotype0.79189613
87MP0000026_abnormal_inner_ear0.78610230
88MP0005171_absent_coat_pigmentation0.78207720
89MP0004215_abnormal_myocardial_fiber0.78037749
90MP0000534_abnormal_ureter_morphology0.77566924
91MP0003633_abnormal_nervous_system0.76629289
92MP0000749_muscle_degeneration0.76097314
93MP0001485_abnormal_pinna_reflex0.75720534
94MP0000747_muscle_weakness0.75242940
95MP0004085_abnormal_heartbeat0.74707846
96MP0002638_abnormal_pupillary_reflex0.74680746
97MP0002751_abnormal_autonomic_nervous0.74532337
98MP0000920_abnormal_myelination0.74231877
99MP0002332_abnormal_exercise_endurance0.72903168
100MP0003632_abnormal_nervous_system0.71928395
101MP0010770_preweaning_lethality0.70722539
102MP0002082_postnatal_lethality0.70722539
103MP0002163_abnormal_gland_morphology0.69539642
104MP0000604_amyloidosis0.68761808
105MP0003634_abnormal_glial_cell0.68760199
106MP0005499_abnormal_olfactory_system0.67120702
107MP0005394_taste/olfaction_phenotype0.67120702
108MP0001986_abnormal_taste_sensitivity0.66459052
109MP0000681_abnormal_thyroid_gland0.65644666
110MP0002102_abnormal_ear_morphology0.64650674
111MP0010769_abnormal_survival0.63817970
112MP0002081_perinatal_lethality0.63159337
113MP0001664_abnormal_digestion0.62857357
114MP0002234_abnormal_pharynx_morphology0.62764288
115MP0005253_abnormal_eye_physiology0.62411675
116MP0003861_abnormal_nervous_system0.61962960
117MP0010768_mortality/aging0.61168135
118MP0002160_abnormal_reproductive_system0.59589520
119MP0009250_abnormal_appendicular_skeleto0.58679263
120MP0005535_abnormal_body_temperature0.58527318
121MP0002295_abnormal_pulmonary_circulatio0.58511382
122MP0008872_abnormal_physiological_respon0.56939177
123MP0002090_abnormal_vision0.56278024
124MP0001943_abnormal_respiration0.56260810
125MP0003942_abnormal_urinary_system0.55458873
126MP0006292_abnormal_olfactory_placode0.55372211
127MP0003137_abnormal_impulse_conducting0.53825686
128MP0003941_abnormal_skin_development0.53248943
129MP0003938_abnormal_ear_development0.50911856
130MP0003183_abnormal_peptide_metabolism0.50452913

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.15009197
2Fibular aplasia (HP:0002990)5.01635941
3Focal seizures (HP:0007359)4.93482317
4Atonic seizures (HP:0010819)4.82304654
5Myokymia (HP:0002411)4.75068162
6Visual hallucinations (HP:0002367)4.58616651
7Epileptic encephalopathy (HP:0200134)4.55448928
8Absence seizures (HP:0002121)4.08228792
9Cerebral inclusion bodies (HP:0100314)4.00994345
10Febrile seizures (HP:0002373)3.98319293
11Neurofibrillary tangles (HP:0002185)3.93278380
12Hyperventilation (HP:0002883)3.77005413
13Dialeptic seizures (HP:0011146)3.64906286
14Generalized tonic-clonic seizures (HP:0002069)3.54088253
15Supranuclear gaze palsy (HP:0000605)3.46775043
16Amblyopia (HP:0000646)3.44044889
17Delayed gross motor development (HP:0002194)3.43173144
18Drooling (HP:0002307)3.31954945
19Excessive salivation (HP:0003781)3.31954945
20Agitation (HP:0000713)3.29708963
21Enlarged epiphyses (HP:0010580)3.25741513
22Progressive cerebellar ataxia (HP:0002073)3.12462667
23Anxiety (HP:0000739)3.08751241
24Broad-based gait (HP:0002136)3.08098390
25Humeroradial synostosis (HP:0003041)3.06386075
26Synostosis involving the elbow (HP:0003938)3.06386075
27Mesomelia (HP:0003027)2.99863022
28Torticollis (HP:0000473)2.99858545
29Symphalangism affecting the phalanges of the hand (HP:0009773)2.92880161
30Sleep apnea (HP:0010535)2.88534334
31Epileptiform EEG discharges (HP:0011182)2.87885236
32Polyphagia (HP:0002591)2.86977439
33Hemiparesis (HP:0001269)2.83802956
34Abnormal ciliary motility (HP:0012262)2.82523830
35Myotonia (HP:0002486)2.80664980
36Acute necrotizing encephalopathy (HP:0006965)2.72717725
37EEG with generalized epileptiform discharges (HP:0011198)2.66453761
38Menstrual irregularities (HP:0000858)2.62141302
39Truncal ataxia (HP:0002078)2.62084237
40Abnormal eating behavior (HP:0100738)2.60983600
41Mutism (HP:0002300)2.57236266
42Dysdiadochokinesis (HP:0002075)2.56649877
43Aplasia/Hypoplasia of the fibula (HP:0006492)2.53337851
44Psychosis (HP:0000709)2.52850523
45Progressive inability to walk (HP:0002505)2.49546576
46Dysmetria (HP:0001310)2.49458278
47Hypsarrhythmia (HP:0002521)2.47942559
48Narrow nasal bridge (HP:0000446)2.45165258
49Diplopia (HP:0000651)2.43139348
50Abnormality of binocular vision (HP:0011514)2.43139348
51Progressive macrocephaly (HP:0004481)2.41664113
52Impaired smooth pursuit (HP:0007772)2.40512117
53Choroideremia (HP:0001139)2.40139919
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.39058590
55Abnormal mitochondria in muscle tissue (HP:0008316)2.38954463
56Gait imbalance (HP:0002141)2.37693709
57Absent speech (HP:0001344)2.34481243
58Fetal akinesia sequence (HP:0001989)2.34312892
59Abnormal respiratory motile cilium physiology (HP:0012261)2.34097755
60Increased serum pyruvate (HP:0003542)2.33880594
61Abnormality of glycolysis (HP:0004366)2.33880594
62Depression (HP:0000716)2.32749609
63Abnormality of the phalanges of the 2nd finger (HP:0009541)2.30699447
64Pheochromocytoma (HP:0002666)2.28555898
65Hydroureter (HP:0000072)2.25588007
66Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.25135329
67Restlessness (HP:0000711)2.25105156
68Blue irides (HP:0000635)2.24625507
69Poor suck (HP:0002033)2.24428516
70Failure to thrive in infancy (HP:0001531)2.23762294
71Type II lissencephaly (HP:0007260)2.23532331
72Abnormality of the proximal phalanges of the hand (HP:0009834)2.22419249
73Heterochromia iridis (HP:0001100)2.18979938
74Abnormality of the phalanges of the 5th finger (HP:0004213)2.12868351
75Action tremor (HP:0002345)2.12536677
76Hyperthyroidism (HP:0000836)2.12494915
77Neuronal loss in central nervous system (HP:0002529)2.11772236
78Limb dystonia (HP:0002451)2.09335534
79Recurrent corneal erosions (HP:0000495)2.08573423
80Hypoventilation (HP:0002791)2.07979855
81Medial flaring of the eyebrow (HP:0010747)2.07550855
82Abnormality of salivation (HP:0100755)2.07190965
83Autoamputation (HP:0001218)2.06503733
84Focal dystonia (HP:0004373)2.04938910
85Impaired vibration sensation in the lower limbs (HP:0002166)2.04221532
86Split foot (HP:0001839)2.03713754
87Craniofacial dystonia (HP:0012179)2.03684052
88Cerebral hypomyelination (HP:0006808)2.03171409
89Exotropia (HP:0000577)2.02301857
90Delusions (HP:0000746)2.02094140
91Abnormal respiratory motile cilium morphology (HP:0005938)2.01529821
92Abnormal respiratory epithelium morphology (HP:0012253)2.01529821
93Fibular hypoplasia (HP:0003038)2.00904342
94Abnormality of the corticospinal tract (HP:0002492)2.00559772
95Radial bowing (HP:0002986)2.00171834
96Acute encephalopathy (HP:0006846)1.99627828
97Lower limb muscle weakness (HP:0007340)1.98250762
98Neuroendocrine neoplasm (HP:0100634)1.97938363
99Global brain atrophy (HP:0002283)1.97887667
100Mitochondrial inheritance (HP:0001427)1.96962123
101Esotropia (HP:0000565)1.96834764
102Short 1st metacarpal (HP:0010034)1.96315043
103Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96315043
104Specific learning disability (HP:0001328)1.95801670
105Retinal dysplasia (HP:0007973)1.94053103
106Short tibia (HP:0005736)1.93343522
107Protruding tongue (HP:0010808)1.93058052
108Rapidly progressive (HP:0003678)1.92945209
109Impaired social interactions (HP:0000735)1.92896850
110Abnormal social behavior (HP:0012433)1.92896850
111Congenital primary aphakia (HP:0007707)1.92488763
112Akinesia (HP:0002304)1.89786587
113Sensory axonal neuropathy (HP:0003390)1.88100645
114Abnormal hair whorl (HP:0010721)1.87824984
115Incomplete penetrance (HP:0003829)1.86412829
116Premature rupture of membranes (HP:0001788)1.86044408
117Morphological abnormality of the pyramidal tract (HP:0002062)1.85956725
118Increased hepatocellular lipid droplets (HP:0006565)1.85333775
119Bradykinesia (HP:0002067)1.85256756
120Nephronophthisis (HP:0000090)1.84669519
121Oligodactyly (hands) (HP:0001180)1.84424847
122Deformed tarsal bones (HP:0008119)1.84013335
123Abnormality of pain sensation (HP:0010832)1.83675645
124Impaired pain sensation (HP:0007328)1.83675645
125Ankle clonus (HP:0011448)1.83199607
126Nephrogenic diabetes insipidus (HP:0009806)1.82971952
127Small hand (HP:0200055)1.82855902
128Scanning speech (HP:0002168)1.82259699
129Generalized myoclonic seizures (HP:0002123)1.81523157
130Abnormality of ocular smooth pursuit (HP:0000617)1.80804928
131Postural instability (HP:0002172)1.80128876
132Increased CSF lactate (HP:0002490)1.80054994
133Termporal pattern (HP:0011008)1.79605968
134Insidious onset (HP:0003587)1.79605968
135Follicular hyperkeratosis (HP:0007502)1.77824860
136Decreased muscle mass (HP:0003199)1.77644437
137Gaze-evoked nystagmus (HP:0000640)1.77103661
138Spastic gait (HP:0002064)1.76361278
139Abnormality of the middle phalanges of the toes (HP:0010183)1.76343600
140Poor eye contact (HP:0000817)1.76328430
141Urinary urgency (HP:0000012)1.75552017
142Degeneration of the lateral corticospinal tracts (HP:0002314)1.70883466
143Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70883466
144Adactyly (HP:0009776)1.67295679
145Osteomalacia (HP:0002749)1.67121145
146Abnormality of the 1st metacarpal (HP:0010009)1.66901580
147Femoral bowing (HP:0002980)1.66482376
148Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65869511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.80840683
2EPHA44.46664866
3TRIM283.96041778
4MARK13.53171222
5CASK3.20464083
6RIPK43.00143253
7MAP3K92.69365297
8MINK12.67353799
9MAP3K42.62789191
10MAP3K122.57358264
11PNCK2.44552737
12MAP2K72.31615323
13MAPK152.14048057
14CAMKK22.00791454
15NTRK21.99598640
16PINK11.99234029
17TESK11.98811587
18LIMK11.88052505
19NME11.81632319
20MAPK131.81128080
21PLK21.76165446
22KSR11.76154814
23SIK21.75052797
24WNK31.72958756
25UHMK11.70475140
26MAP2K41.66818052
27BMPR21.63297032
28PAK31.57556714
29CSNK1A1L1.56947313
30PAK61.51191868
31TNIK1.50913770
32TLK11.48527958
33KSR21.47910979
34CAMK2A1.45640763
35FES1.39539112
36CAMK2B1.36722708
37MUSK1.32392327
38CDK51.31199935
39GRK51.24283205
40PRKCG1.23703200
41DAPK11.19603898
42PTK2B1.16260677
43CSNK1G11.06089271
44FGR1.02518955
45MARK21.00841528
46DYRK1A1.00526585
47DAPK20.97876549
48NTRK10.96288354
49BCR0.89837044
50CDK180.84072607
51PIM20.81518851
52WNK40.80528873
53CAMK2D0.80154091
54CAMK2G0.79446512
55CDK140.79269836
56TSSK60.78796913
57OXSR10.77793330
58CDK150.77250298
59CAMK1G0.76865491
60CDK190.76858576
61LATS20.75793267
62ERBB30.75535637
63CLK10.75442940
64FER0.74586926
65TYRO30.74190866
66MAP3K20.73935290
67ARAF0.71374295
68PIK3CG0.71154476
69SGK10.70506563
70SIK30.68464704
71CDK11A0.66626715
72DDR20.66561521
73PRKD30.62886326
74PHKG20.61945772
75PHKG10.61945772
76PRKCE0.61426437
77ADRBK20.60706967
78STK160.60510928
79AKT30.60286568
80RAF10.59238170
81SRPK10.59026185
82PDGFRA0.58914263
83DYRK20.58173542
84ROCK20.56812521
85BRSK10.55657732
86EPHB20.55617432
87CSNK1G20.53372025
88CAMKK10.52857488
89GRK60.52495412
90PRKCZ0.51751309
91MAPK120.51722185
92MAP3K110.50599315
93* PRKACA0.47864005
94SGK2230.46091910
95SGK4940.46091910
96* ADRBK10.45945921
97RET0.45367039
98PRKAA10.45222030
99PRKG10.44366040
100MAPK100.43445484
101RPS6KA30.43421421
102CSNK1E0.43021937
103CAMK10.42858955
104PRPF4B0.42347284
105FYN0.41786592
106STK380.41619156
107CSNK1D0.40523787
108TNK20.39661115
109MAP3K130.39388355
110CDK90.39350008
111PRKCB0.39062086
112* PRKCA0.38808153
113MAP2K10.38771790
114STK390.37600184
115EPHA30.37127041
116STK110.36972294
117PKN10.35025981
118MAP3K60.34352257
119MAP3K10.32011975
120ERBB40.31977791
121* PRKACG0.31573015
122SGK20.31159068
123CSNK1G30.30113432
124PRKCQ0.29142054
125CDC70.29109853
126CDK30.29075076
127MAPK90.28467968
128EPHB10.28229425
129CSNK1A10.27964939
130MAP3K50.27113405
131MOS0.26740558
132RPS6KA20.25730539
133PRKACB0.25603782
134PRKCD0.24699329
135MAPK80.23486131
136SRC0.23225959
137BMPR1B0.23202589
138MATK0.22804222
139ICK0.21770228

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.91403905
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.05273408
3Long-term potentiation_Homo sapiens_hsa047202.76219772
4GABAergic synapse_Homo sapiens_hsa047272.76150352
5Circadian entrainment_Homo sapiens_hsa047132.69499272
6Amphetamine addiction_Homo sapiens_hsa050312.65058602
7Morphine addiction_Homo sapiens_hsa050322.61662373
8Glutamatergic synapse_Homo sapiens_hsa047242.60589128
9Synaptic vesicle cycle_Homo sapiens_hsa047212.51760088
10Dopaminergic synapse_Homo sapiens_hsa047282.29616611
11Renin secretion_Homo sapiens_hsa049242.20743914
12Serotonergic synapse_Homo sapiens_hsa047262.16550486
13Salivary secretion_Homo sapiens_hsa049702.15185116
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12015266
15Olfactory transduction_Homo sapiens_hsa047402.09753104
16Oxidative phosphorylation_Homo sapiens_hsa001902.07976696
17Taste transduction_Homo sapiens_hsa047422.02117020
18Insulin secretion_Homo sapiens_hsa049112.00898540
19Collecting duct acid secretion_Homo sapiens_hsa049661.98467806
20Long-term depression_Homo sapiens_hsa047301.94529041
21Gastric acid secretion_Homo sapiens_hsa049711.73469132
22Cocaine addiction_Homo sapiens_hsa050301.73374006
23Alzheimers disease_Homo sapiens_hsa050101.72289859
24Calcium signaling pathway_Homo sapiens_hsa040201.71243023
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62912250
26Cholinergic synapse_Homo sapiens_hsa047251.59655243
27Oxytocin signaling pathway_Homo sapiens_hsa049211.57948989
28Vibrio cholerae infection_Homo sapiens_hsa051101.57634186
29* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54863354
30Cardiac muscle contraction_Homo sapiens_hsa042601.53922146
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53738303
32Parkinsons disease_Homo sapiens_hsa050121.50452093
33Axon guidance_Homo sapiens_hsa043601.49813438
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48972957
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34085099
36Gap junction_Homo sapiens_hsa045401.28275171
37cAMP signaling pathway_Homo sapiens_hsa040241.27300505
38GnRH signaling pathway_Homo sapiens_hsa049121.26645683
39Huntingtons disease_Homo sapiens_hsa050161.23381108
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23214095
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18442753
42Estrogen signaling pathway_Homo sapiens_hsa049151.14214685
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13179978
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08355569
45Phototransduction_Homo sapiens_hsa047441.05648886
46Melanogenesis_Homo sapiens_hsa049161.03601683
47Thyroid hormone synthesis_Homo sapiens_hsa049181.00097077
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96489494
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.94875657
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91848287
51Hippo signaling pathway_Homo sapiens_hsa043900.86407986
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85195513
53Glioma_Homo sapiens_hsa052140.81059225
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78612737
55Type II diabetes mellitus_Homo sapiens_hsa049300.78312734
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78248103
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76791982
58Prion diseases_Homo sapiens_hsa050200.76516857
59Glucagon signaling pathway_Homo sapiens_hsa049220.74955138
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74861447
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74830482
62Pancreatic secretion_Homo sapiens_hsa049720.74423810
63Vitamin B6 metabolism_Homo sapiens_hsa007500.73781018
64Oocyte meiosis_Homo sapiens_hsa041140.68542720
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68316503
66ErbB signaling pathway_Homo sapiens_hsa040120.66873950
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66091228
68Salmonella infection_Homo sapiens_hsa051320.64267775
69Dilated cardiomyopathy_Homo sapiens_hsa054140.63561478
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60929594
71African trypanosomiasis_Homo sapiens_hsa051430.57709509
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56484579
73MAPK signaling pathway_Homo sapiens_hsa040100.54487861
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53060781
75Melanoma_Homo sapiens_hsa052180.51122305
76Choline metabolism in cancer_Homo sapiens_hsa052310.48975517
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47612778
78Wnt signaling pathway_Homo sapiens_hsa043100.44863704
79Type I diabetes mellitus_Homo sapiens_hsa049400.44293717
80Ras signaling pathway_Homo sapiens_hsa040140.44151024
81VEGF signaling pathway_Homo sapiens_hsa043700.44060436
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42921426
83Alcoholism_Homo sapiens_hsa050340.42071075
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.40958862
85Endocytosis_Homo sapiens_hsa041440.40250768
86Rheumatoid arthritis_Homo sapiens_hsa053230.39400646
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39118656
88Fatty acid elongation_Homo sapiens_hsa000620.37663302
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36435507
90Rap1 signaling pathway_Homo sapiens_hsa040150.34158250
91Bile secretion_Homo sapiens_hsa049760.33769898
92Protein digestion and absorption_Homo sapiens_hsa049740.31225886
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30395072
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30222942
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28004194
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.27745754
97Renal cell carcinoma_Homo sapiens_hsa052110.27573512
98Inositol phosphate metabolism_Homo sapiens_hsa005620.26344188
99Hedgehog signaling pathway_Homo sapiens_hsa043400.26249532
100AMPK signaling pathway_Homo sapiens_hsa041520.26188019
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25819812
102Phagosome_Homo sapiens_hsa041450.25263955
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25028211
104Ovarian steroidogenesis_Homo sapiens_hsa049130.24705812
105Ether lipid metabolism_Homo sapiens_hsa005650.21969957
106Dorso-ventral axis formation_Homo sapiens_hsa043200.21741413
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21598128
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21278129
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.20088340
110Sphingolipid metabolism_Homo sapiens_hsa006000.19517458
111Other glycan degradation_Homo sapiens_hsa005110.18514516
112Galactose metabolism_Homo sapiens_hsa000520.18499067
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17764871
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16864930
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15814427
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14810752
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14160693
118Circadian rhythm_Homo sapiens_hsa047100.11771690
119Protein export_Homo sapiens_hsa030600.11474588
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10568340
121Butanoate metabolism_Homo sapiens_hsa006500.10271024
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10023135
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09711393

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